GALNT2

Summary

Gene Symbol: GALNT2
Description: polypeptide N-acetylgalactosaminyltransferase 2
Alias: GalNAc-T2, polypeptide N-acetylgalactosaminyltransferase 2, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), polypeptide GalNAc transferase 2, pp-GaNTase 2
Species: human
Products:     GALNT2

Top Publications

  1. Polgar N, Jaromi L, Csongei V, Maasz A, Sipeky C, Safrany E, et al. Triglyceride level modifying functional variants of GALTN2 and MLXIPL in patients with ischaemic stroke. Eur J Neurol. 2010;17:1033-9 pubmed publisher
    ..associated with triglyceride-level changes, rs17145738 and rs3812316 of the MLXIPL locus, and rs4846914 variant of GALNT2 gene in biobanked samples of patients with stroke...
  2. Rottger S, White J, Wandall H, Olivo J, Stark A, Bennett E, et al. Localization of three human polypeptide GalNAc-transferases in HeLa cells suggests initiation of O-linked glycosylation throughout the Golgi apparatus. J Cell Sci. 1998;111 ( Pt 1):45-60 pubmed
  3. Wu Y, Liu C, Hu R, Huang M, Lee J, Chen C, et al. Mucin glycosylating enzyme GALNT2 regulates the malignant character of hepatocellular carcinoma by modifying the EGF receptor. Cancer Res. 2011;71:7270-9 pubmed publisher
    ..Here, we report that N-acetylgalactosaminyltransferase 2 (GALNT2), the enzyme that mediates the initial step of mucin type-O glycosylation, is a critical mediator of malignant ..
  4. Wang J, Ban M, Zou G, Cao H, Lin T, Kennedy B, et al. Polygenic determinants of severe hypertriglyceridemia. Hum Mol Genet. 2008;17:2894-9 pubmed publisher
    ..We determined genotypes for: GALNT2 rs4846914, TBL2/MLXIPL rs17145738, TRIB1 rs17321515, ANGPTL3 rs12130333, GCKR rs780094, APOA5 rs3135506 (S19W), ..
  5. Teslovich T, Musunuru K, Smith A, Edmondson A, Stylianou I, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-13 pubmed publisher
    ..Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models...
  6. Hegele R, Ban M, Hsueh N, Kennedy B, Cao H, Zou G, et al. A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia. Hum Mol Genet. 2009;18:4189-94 pubmed publisher
    ..S19W and -1131T>C, TRIB1 rs17321515, TBL2 rs17145738, GCKR rs780094, GALNT2 rs4846914 and ANGPTL3 rs12130333, were significantly associated with HLP types 2B, 3, 4 and 5...
  7. Lin M, Huang M, Liu C, Yang T, Huang M. GALNT2 enhances migration and invasion of oral squamous cell carcinoma by regulating EGFR glycosylation and activity. Oral Oncol. 2014;50:478-84 pubmed publisher
    ..This study aimed to explore the role of N-acetylgalactosaminyltransferase 2 (GALNT2) in OSCC. Immunohistochemistry was performed to study the expression of GALNT2 in an OSCC tissue microarray...
  8. Nakayama K, Bayasgalan T, Yamanaka K, Kumada M, Gotoh T, Utsumi N, et al. Large scale replication analysis of loci associated with lipid concentrations in a Japanese population. J Med Genet. 2009;46:370-4 pubmed publisher
    ..1x10(-11), 4.7 mg/dl decrease per minor G allele) in the Japanese population. SNPs near ANGPTL3, TRIB1 and GALNT2 showed evidence for associations with triglyceride concentrations (3.6x10(-6)<p<5.1x10(-5))...
  9. Tietjen I, Hovingh G, Singaraja R, Radomski C, Barhdadi A, McEwen J, et al. Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol. PLoS ONE. 2012;7:e37437 pubmed publisher
    ..Here we sequenced the coding regions and adjacent sequence of the LIPG, CETP, and GALNT2 genes in 171 unrelated Dutch Caucasian probands with HDLc?90th percentile and analyzed segregation of mutations ..

More Information

Publications81

  1. Weissglas Volkov D, Aguilar Salinas C, Sinsheimer J, Riba L, Huertas Vazquez A, Ordoñez Sánchez M, et al. Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples. Circ Cardiovasc Genet. 2010;3:31-8 pubmed publisher
    ..These variants were within or near the genes ABCA1, ANGPTL3, APOA5, APOB, CETP, GALNT2, GCKR, LCAT, LIPC, LPL (2), MMAB-MVK, TRIB1, and XKR6-AMAC1L2...
  2. Wandall H, Hassan H, Mirgorodskaya E, Kristensen A, Roepstorff P, Bennett E, et al. Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3. J Biol Chem. 1997;272:23503-14 pubmed
    ..The results demonstrate that individual GalNAc-transferases have distinct activities and the initiation of O-glycosylation in a cell is regulated by a repertoire of GalNAc-transferases. ..
  3. Zlocowski N, Sendra V, Lorenz V, Villarreal M, Jorge A, Nuñez Y, et al. Catalytic and glycan-binding abilities of ppGalNAc-T2 are regulated by acetylation. Biochem Biophys Res Commun. 2011;410:140-5 pubmed publisher
    ..Taken together, these findings clearly indicate that biological activity (catalytic capacity and glycan-binding ability) of ppGalNAc-T2 is regulated by acetylation. ..
  4. Tai E, Sim X, Ong T, Wong T, Saw S, Aung T, et al. Polymorphisms at newly identified lipid-associated loci are associated with blood lipids and cardiovascular disease in an Asian Malay population. J Lipid Res. 2009;50:514-20 pubmed publisher
    ..polymorphisms on chromosome 19 adjacent to the CILP2 and PBX4 loci (rs16996148) and on chromosome 1 at the GALNT2 locus (rs4846914) were associated with elevated HDL-C (P = 0.005) and lower LDL-C (P = 0.048), respectively...
  5. Holleboom A, Karlsson H, Lin R, Beres T, Sierts J, Herman D, et al. Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man. Cell Metab. 2011;14:811-8 pubmed publisher
    Genome-wide association studies have identified GALNT2 as a candidate gene in lipid metabolism, but it is not known how the encoded enzyme ppGalNAc-T2, which contributes to the initiation of mucin-type O-linked glycosylation, mediates ..
  6. Pikó P, Fiatal S, Kósa Z, Sandor J, Adany R. Generalizability and applicability of results obtained from populations of European descent regarding the effect direction and size of HDL-C level-associated genetic variants to the Hungarian general and Roma populations. Gene. 2019;686:187-193 pubmed publisher
    ..The associations between 21 SNPs (in the genes LIPC(G), CETP, GALNT2, HMGCP, ABCA1, KCTD10 and WWOX) and HDL-C levels were examined separately in adults of the Hungarian general (N =..
  7. Hintze J, Ye Z, Narimatsu Y, Madsen T, Joshi H, Goth C, et al. Probing the contribution of individual polypeptide GalNAc-transferase isoforms to the O-glycoproteome by inducible expression in isogenic cell lines. J Biol Chem. 2018;293:19064-19077 pubmed publisher
    ..this, here we developed isogenic cell model systems with Tet-On inducible expression of two GalNAc-T genes, GALNT2 and GALNT11, in a knockout background in HEK293 cells...
  8. Nordén R, Halim A, Nyström K, Bennett E, Mandel U, Olofsson S, et al. O-linked glycosylation of the mucin domain of the herpes simplex virus type 1-specific glycoprotein gC-1 is temporally regulated in a seed-and-spread manner. J Biol Chem. 2015;290:5078-91 pubmed publisher
    ..Because the GalNAc occupancy pattern is of relevance for receptor binding of gC-1, the data provide a model to delineate biosynthetic steps of O-linked glycosylation of the gC-1 mucin domain in HSV-1-infected target cells. ..
  9. Mueller P, Gauttam R, Raab N, Handrick R, Wahl C, Leptihn S, et al. High level in vivo mucin-type glycosylation in Escherichia coli. Microb Cell Fact. 2018;17:168 pubmed publisher
    ..The results offer the possibility to assess the practical use of the described expression platform for in vivo glycosylations of important biopharmaceutical compounds in E. coli. ..
  10. Lauber J, Handrick R, Leptihn S, Dürre P, Gaisser S. Expression of the functional recombinant human glycosyltransferase GalNAcT2 in Escherichia coli. Microb Cell Fact. 2015;14:3 pubmed publisher
    ..coli. The functional activity of the enzyme was shown in vitro. Further investigations are needed to assess the potential of in vivo glycosylation in E. coli. ..
  11. Tsuchida A, Senda M, Ito A, Saito S, Kiso M, Ando T, et al. Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells. Sci Rep. 2018;8:7017 pubmed publisher
    ..These results suggested that GalNAc-DSLc4 is involved in malignant properties of RCCs by forming a molecular complex with integrins in lipid rafts. ..
  12. Khetarpal S, Babb P, Zhao W, Hancock Cerutti W, Brown C, Rader D, et al. Multiplexed Targeted Resequencing Identifies Coding and Regulatory Variation Underlying Phenotypic Extremes of High-Density Lipoprotein Cholesterol in Humans. Circ Genom Precis Med. 2018;11:e002070 pubmed publisher
    ..Our targets included protein-coding regions of GALNT2, APOA5, APOC3, SCARB1, CCDC92, ZNF664, CETP, and LIPG (>9 ..
  13. Xiao H, Liang L, Luo Z, Sun Z. Paeoniflorin regulates GALNT2-ANGPTL3-LPL pathway to attenuate dyslipidemia in mice. Eur J Pharmacol. 2018;836:122-128 pubmed publisher
    N-acetylgalactosaminyltransferase 2-Angiopoietin-like protein 3-lipoprotein lipase (GALNT2-ANGPTL3-LPL) pathway may be a useful pharmacologic objective for dyslipidemia...
  14. King S, Goth C, Eckhard U, Joshi H, Haue A, Vakhrushev S, et al. TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation. J Biol Chem. 2018;293:7629-7644 pubmed publisher
    ..B and the phospholipid transfer protein, providing new clues to the previously reported link between GALNT2 and lipid homeostasis...
  15. Gómez H, Rojas R, Patel D, Tabak L, Lluch J, Masgrau L. A computational and experimental study of O-glycosylation. Catalysis by human UDP-GalNAc polypeptide:GalNAc transferase-T2. Org Biomol Chem. 2014;12:2645-55 pubmed publisher
  16. Sümegi K, Jaromi L, Magyari L, Kovesdi E, Duga B, Szalai R, et al. Functional variants of lipid level modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 genes in healthy Roma and Hungarian populations. Pathol Oncol Res. 2015;21:743-9 pubmed publisher
    ..ANGPTL3, rs16996148 at the CILP2, rs17321515 at the TRIB1, rs17145738 and rs3812316 of the MLXIPL, rs4846914 at GALNT2, rs1260326 and rs780094 residing at the GCKR loci...
  17. Zabaneh D, Kumari M, Sandhu M, Wareham N, Wainwright N, Papamarkou T, et al. Meta analysis of candidate gene variants outside the LPA locus with Lp(a) plasma levels in 14,500 participants of six White European cohorts. Atherosclerosis. 2011;217:447-51 pubmed publisher
    ..the LPA locus (where p values for several SNPs were <10(-30)) there was significant association at four loci GALNT2, FABP1, PPARGC1A and TNFRSFF11A. However, a meta-analysis of the six studies did not confirm any of these findings...
  18. Cavalli M, Pan G, Nord H, Wallén Arzt E, Wallerman O, Wadelius C. Allele-specific transcription factor binding in liver and cervix cells unveils many likely drivers of GWAS signals. Genomics. 2016;107:248-54 pubmed publisher
    ..A recent study investigated many variants before finding the functional ones at the GALNT2 locus, which we found in our genome-wide screen in HepG2. This illustrates the efficiency of our approach.
  19. Singaraja R, Tietjen I, Hovingh G, Franchini P, Radomski C, Wong K, et al. Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans. J Lipid Res. 2014;55:1693-701 pubmed publisher
    ..endothelial lipase (LIPG), and UDP-N-acetyl-?-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2). We identified 93 novel coding or splice-site variants in 72 candidate genes...
  20. Schjoldager K, Joshi H, Kong Y, Goth C, King S, Wandall H, et al. Deconstruction of O-glycosylation--GalNAc-T isoforms direct distinct subsets of the O-glycoproteome. EMBO Rep. 2015;16:1713-22 pubmed publisher
    ..Our study provides a new view of the differential regulation of the O-glycoproteome, suggesting that the plurality of GalNAc-Ts arose to regulate distinct protein functions and cellular processes. ..
  21. Vitali C, Khetarpal S, Rader D. HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics. Curr Cardiol Rep. 2017;19:132 pubmed publisher
    ..discoveries for selected key HDL-C genes CETP, LCAT, LIPG, SCARB1, and novel loci implicated from GWAS including GALNT2, KLF14, and TTC39B...
  22. Di Paola R, Marucci A, Trischitta V. GALNT2 effect on HDL-cholesterol and triglycerides levels in humans: Evidence of pleiotropy?. Nutr Metab Cardiovasc Dis. 2017;27:281-282 pubmed publisher
    A wide range of studies both in humans and animal models point GALNT2 as a shaper of serum HDL-C and TG levels...
  23. Gómez H, Mendoza F, Lluch J, Masgrau L. QM/MM Studies Reveal How Substrate-Substrate and Enzyme-Substrate Interactions Modulate Retaining Glycosyltransferases Catalysis and Mechanism. Adv Protein Chem Struct Biol. 2015;100:225-54 pubmed publisher
    ..Moreover, they provide an explanation on why in some cases a strong nucleophilic residue is found on the β-face of the sugar, opening the door to a shift toward a double-displacement mechanism. ..
  24. Nebendahl C, Görs S, Albrecht E, Krüger R, Martens K, Giller K, et al. Early postnatal feed restriction reduces liver connective tissue levels and affects H3K9 acetylation state of regulated genes associated with protein metabolism in low birth weight pigs. J Nutr Biochem. 2016;29:41-55 pubmed publisher
    ..In U animals, R induced H3K9 acetylation of regulated genes (e.g. XBP1, ERLEC1, GALNT2, PTRH2), which were inter alia associated with protein metabolism...
  25. Xie G, Myint P, Voora D, Laskowitz D, Shi P, Ren F, et al. Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort. Atherosclerosis. 2015;243:30-7 pubmed publisher
    ..at genome level (p < 1 × 10(-7)) and seven novel SNPs (rs2230307 in AGL gene on chromosome 1, rs12040273 in GALNT2 gene on chromosome 1, rs4536103 in NEUROG3 gene on chromosome 10, rs9855415 in LOC647323 gene on chromosome 3, ..
  26. Goth C, Halim A, Khetarpal S, Rader D, Clausen H, Schjoldager K. A systematic study of modulation of ADAM-mediated ectodomain shedding by site-specific O-glycosylation. Proc Natl Acad Sci U S A. 2015;112:14623-8 pubmed publisher
    ..by O-glycosylation controlled by the GalNAc-T2 isoform both ex vivo in isogenic cell models and in vivo in mouse Galnt2 knockouts...
  27. Goth C, Tuhkanen H, Khan H, Lackman J, Wang S, Narimatsu Y, et al. Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage. J Biol Chem. 2017;292:4714-4726 pubmed publisher
    ..The results provide a new level of β1AR regulation that may open up possibilities for new therapeutic strategies for cardiovascular diseases. ..
  28. Marcos N, Cruz A, Silva F, Almeida R, David L, Mandel U, et al. Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines. J Histochem Cytochem. 2003;51:761-71 pubmed
    ..The expression of ST6GalNAc-I is low in gastric cell lines, in accordance with the low/absent expression of the Sialyl-Tn antigen. ..
  29. Khetarpal S, Schjoldager K, Christoffersen C, Raghavan A, Edmondson A, Reutter H, et al. Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metab. 2016;24:234-45 pubmed publisher
    Human genetics studies have implicated GALNT2, encoding GalNAc-T2, as a regulator of high-density lipoprotein cholesterol (HDL-C) metabolism, but the mechanisms relating GALNT2 to HDL-C remain unclear...
  30. Bennett E, Weghuis D, Merkx G, van Kessel A, Eiberg H, Clausen H. Genomic organization and chromosomal localization of three members of the UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase family. Glycobiology. 1998;8:547-55 pubmed
    ..These results suggest that the members of the polypeptide GalNAc-transferase family diverged early in evolution from a common ancestral gene through gene duplication. ..
  31. Ghirardello M, de Las Rivas M, Lacetera A, Delso I, Lira Navarrete E, Tejero T, et al. Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates. Chemistry. 2016;22:7215-24 pubmed publisher
    ..Computational studies with GalNAc-T2 corroborate these findings and provide further insights into the mechanism of the catalytic cycle of this family of enzymes. ..
  32. Liao W, Liu C, Huang M, Chen C, Hung J, Chou C, et al. Expression of GALNT2 in human extravillous trophoblasts and its suppressive role in trophoblast invasion. Placenta. 2012;33:1005-11 pubmed publisher
    ..Here, we found that the GALNT1 and GALNT2 mRNA were highly expressed in HTR8/SVneo and first trimester EVT cells...
  33. Gill D, Tham K, Chia J, Wang S, Steentoft C, Clausen H, et al. Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness. Proc Natl Acad Sci U S A. 2013;110:E3152-61 pubmed publisher
    ..Our findings suggest that relocation of GalNAc-Ts to the endoplasmic reticulum frequently occurs upon cancerous transformation to enhance tumor cell migration and invasiveness through modification of cell surface proteins. ..
  34. Iwasaki H, Zhang Y, Tachibana K, Gotoh M, Kikuchi N, Kwon Y, et al. Initiation of O-glycan synthesis in IgA1 hinge region is determined by a single enzyme, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2. J Biol Chem. 2003;278:5613-21 pubmed
    ..We found that pp-GalNAc-T2 selectively transferred GalNAc residues to the same five positions. These results strongly suggested that pp-GalNAc-T2 is an essential enzyme for initiation of O-linked glycosylation of the IgA1 hinge region. ..
  35. Marucci A, Di Mauro L, Menzaghi C, Prudente S, Mangiacotti D, Fini G, et al. GALNT2 expression is reduced in patients with Type 2 diabetes: possible role of hyperglycemia. PLoS ONE. 2013;8:e70159 pubmed publisher
    ..Down-regulation of GALNT2, an UDPN-acetyl-alpha-D-galactosamine polypeptideN-acetylgalactosaminyltransferase-2 (ppGalNAc-T2), causes ..
  36. Kinarsky L, Suryanarayanan G, Prakash O, Paulsen H, Clausen H, Hanisch F, et al. Conformational studies on the MUC1 tandem repeat glycopeptides: implication for the enzymatic O-glycosylation of the mucin protein core. Glycobiology. 2003;13:929-39 pubmed
  37. Sheta R, Bachvarova M, Plante M, Gregoire J, Renaud M, Sebastianelli A, et al. Altered expression of different GalNAc?transferases is associated with disease progression and poor prognosis in women with high-grade serous ovarian cancer. Int J Oncol. 2017;51:1887-1897 pubmed publisher
    ..In silico analysis based on publically available data was indicative for altered expression of five GalNAc?Ts (GALNT2, T4, T6, T9 and T14) in ovarian high-grade serous carcinoma (HGSC) samples compared to non-tumoral (control) ..
  38. Zhang X, Zhao H, Zhang J, Han D, Zheng Y, Guo X, et al. Gene environment interaction of GALNT2 and APOE gene with hypertension in the Chinese Han Population. Biomed Mater Eng. 2015;26 Suppl 1:S1977-83 pubmed publisher
    In some GWAs studies, GALNT2 and APOE polymorphisms have been identified to be related to alterations of plasma or serum HDL-C and TG concentrations...
  39. Lackman J, Goth C, Halim A, Vakhrushev S, Clausen H, Petäjä Repo U. Site-specific O-glycosylation of N-terminal serine residues by polypeptide GalNAc-transferase 2 modulates human ?-opioid receptor turnover at the plasma membrane. Cell Signal. 2018;42:184-193 pubmed publisher
    ..Thus, site-specific O-glycosylation by a selected GalNAc-T isoform can increase the stability of a GPCR, in a process that modulates the constitutive turnover and steady-state levels of functional receptors at the cell surface. ..
  40. Xiao H, Wang J, Sun Z. ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL inhibition in mastitis mice. Exp Mol Pathol. 2017;103:242-248 pubmed publisher
    ..lipase (LPL) activities in postheparin plasma; expressions of hepatic N-acetylgalactosaminyltransferase 2 (GALNT2), hepatic ANGPTL3 and adipose LPL were determined...
  41. Roman T, Marvelle A, Fogarty M, Vadlamudi S, Gonzalez A, Buchkovich M, et al. Multiple Hepatic Regulatory Variants at the GALNT2 GWAS Locus Associated with High-Density Lipoprotein Cholesterol. Am J Hum Genet. 2015;97:801-15 pubmed publisher
    ..We examined the functional regulatory effects of candidate variants at the GALNT2 locus associated with high-density lipoprotein cholesterol (HDL-C)...
  42. Nimmo E, Stevens C, Phillips A, Smith A, Drummond H, Noble C, et al. TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease. Gastroenterology. 2011;141:972-981.e1-2 pubmed publisher
    ..proteins (TLE1, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 [GALNT2], HIV-1 Tat interactive protein [HTATIP], Vimentin, fission 1 (mitochondrial outer membrane) homolog [FIS1], and ..
  43. Storrie B, White J, Rottger S, Stelzer E, Suganuma T, Nilsson T. Recycling of golgi-resident glycosyltransferases through the ER reveals a novel pathway and provides an explanation for nocodazole-induced Golgi scattering. J Cell Biol. 1998;143:1505-21 pubmed
    ..In conclusion, we have shown that Golgi-resident glycosylation enzymes recycle through the ER and that this novel pathway is the likely explanation for the nocodazole-induced Golgi scattering observed in interphase cells. ..
  44. ARGUESO P, Tisdale A, Mandel U, Letko E, Foster C, Gipson I. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Invest Ophthalmol Vis Sci. 2003;44:86-92 pubmed
    ..This early increase in isoenzymes in nonkeratinized OCP epithelia is reduced as keratinization proceeds in the disease. ..
  45. Deo R, Reich D, Tandon A, Akylbekova E, Patterson N, Waliszewska A, et al. Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study. PLoS Genet. 2009;5:e1000342 pubmed publisher
  46. Peng P, Wang L, Yang X, Huang X, Ba Y, Chen X, et al. A preliminary study of the relationship between promoter methylation of the ABCG1, GALNT2 and HMGCR genes and coronary heart disease. PLoS ONE. 2014;9:e102265 pubmed publisher
    To investigate the association of ABCG1, GALNT2 and HMGCR genes promoter DNA methylation with coronary heart disease (CHD) and explore the interaction between their methylation status and the CHD patients' clinical characteristics in Han ..
  47. Marucci A, Mangiacotti D, Trischitta V, Di Paola R. GALNT2 mRNA levels are associated with serum triglycerides in humans. Endocrine. 2016;53:331-4 pubmed publisher
  48. Marques Vidal P, Bochud M, Paccaud F, Waterworth D, Bergmann S, Preisig M, et al. No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. Atherosclerosis. 2010;211:551-7 pubmed publisher
    ..To assess the relationships and possible interactions between polymorphisms related to HDL levels and alcohol consumption...
  49. Hong K, Jin H, Song D, Kwak H, Kim S, Kim Y. Genome-wide association study of serum albumin:globulin ratio in Korean populations. J Hum Genet. 2013;58:174-7 pubmed publisher
    ..0 × 10(-4)). These 38 signals were tested in the Ansung population. Eleven SNPs from six loci (GALNT2, IRF4, HLA-DBP1, SLC31A1, FADS1 and TNFRSF13B) were replicated, with P-values<0.05...
  50. Liu S, Shun C, Hung K, Juan H, Hsu C, Huang M, et al. Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylation. Oncotarget. 2016;7:11251-62 pubmed publisher
    Glycosylation affects malignancy in cancer. Here, we report that N- acetylgalactosaminyltransferase 2 (GALNT2), an enzyme that mediates the initial step of mucin type-O glycosylation, suppresses malignant phenotypes in gastric ..
  51. Cavalli M, Pan G, Nord H, Wadelius C. Looking beyond GWAS: allele-specific transcription factor binding drives the association of GALNT2 to HDL-C plasma levels. Lipids Health Dis. 2016;15:18 pubmed publisher
    ..genome wide association studies (GWASs) which identified, among others, variants in the first intron of the GALNT2 gene strongly associated to HDL-C levels...
  52. Li Q, Yin R, Yan T, Miao L, Cao X, Hu X, et al. Association of the GALNT2 gene polymorphisms and several environmental factors with serum lipid levels in the Mulao and Han populations. Lipids Health Dis. 2011;10:160 pubmed publisher
    The association of UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 2 gene (GALNT2) single nucleotide polymorphisms (SNPs) and serum lipid profiles in the general population is not well known...
  53. Muller S, Goletz S, Packer N, Gooley A, Lawson A, Hanisch F. Localization of O-glycosylation sites on glycopeptide fragments from lactation-associated MUC1. All putative sites within the tandem repeat are glycosylation targets in vivo. J Biol Chem. 1997;272:24780-93 pubmed
  54. Lorenz V, Ditamo Y, Cejas R, Carrizo M, Bennett E, Clausen H, et al. Extrinsic Functions of Lectin Domains in O-N-Acetylgalactosamine Glycan Biosynthesis. J Biol Chem. 2016;291:25339-25350 pubmed
  55. Fritz T, Raman J, Tabak L. Dynamic association between the catalytic and lectin domains of human UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferase-2. J Biol Chem. 2006;281:8613-9 pubmed
    ..The structure of the hT2-UDP-EA2 complex also resolves long standing questions regarding ppGalNAcT acceptor substrate specificity. ..
  56. Moy K, Mondul A, Zhang H, Weinstein S, Wheeler W, Chung C, et al. Genome-wide association study of circulating vitamin D-binding protein. Am J Clin Nutr. 2014;99:1424-31 pubmed publisher
    ..Understanding the genetic contributions to circulating DBP may provide greater insights into the vitamin D binding, transport, and other functions of DBP and the effect of vitamin D status on health outcomes. ..
  57. Willer C, Mohlke K. Finding genes and variants for lipid levels after genome-wide association analysis. Curr Opin Lipidol. 2012;23:98-103 pubmed publisher
    ..Experimental follow-up of three loci identified by GWAS has identified functional genes GALNT2, TRIB1, and SORT1, and a functional variant at SORT1...
  58. Keebler M, Deo R, Surti A, Konieczkowski D, Guiducci C, Burtt N, et al. Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. Circ Cardiovasc Genet. 2010;3:358-64 pubmed publisher
    ..To further evaluate these loci, fine-mapping in larger African American cohorts and/or resequencing will be required. ..
  59. Raman J, Fritz T, Gerken T, Jamison O, Live D, Liu M, et al. The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection. J Biol Chem. 2008;283:22942-51 pubmed publisher
    ..Local sequence recognition by the catalytic domain differs between hT2 and hT10 in that hT10 requires a pre-existing GalNAc residue while hT2 does not. ..
  60. White T, Bennett E, Takio K, Sørensen T, Bonding N, Clausen H. Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1995;270:24156-65 pubmed
    ..The data suggest that the purified human GalNAc-transferase is a novel member of a family of polypeptide GalNAc-transferases, and a nomenclature GalNAc-T1 and GalNAc-T2 is introduced to distinguish the members. ..
  61. Reiner A, Hartiala J, Zeller T, Bis J, Dupuis J, Fornage M, et al. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Hum Mol Genet. 2013;22:3381-93 pubmed publisher
    ..The clinical implications for CAD and a better understanding of the functional basis for the association of CFH and MPO variants with circulating MPO levels require further study. ..
  62. Guo T, Yin R, Lin W, Wang W, Huang F, Pan S. Association of the variants and haplotypes in the DOCK7, PCSK9 and GALNT2 genes and the risk of hyperlipidaemia. J Cell Mol Med. 2016;20:243-65 pubmed publisher
    ..pro-protein convertase subtilisin/kexin type 9 (PCSK9) and polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) and serum lipid traits in the Chinese populations...
  63. Ho W, Chou C, Jeng Y, Lu M, Yang Y, Jou S, et al. GALNT2 suppresses malignant phenotypes through IGF-1 receptor and predicts favorable prognosis in neuroblastoma. Oncotarget. 2014;5:12247-59 pubmed
    ..N-acetylgalactosaminyltransferase 2 (GALNT2), one of the enzymes that mediate the initial step of mucin-type O-glycosylation, is responsible for forming Tn ..
  64. Mattu T, Pleass R, Willis A, Kilian M, Wormald M, Lellouch A, et al. The glycosylation and structure of human serum IgA1, Fab, and Fc regions and the role of N-glycosylation on Fc? receptor interactions. J Biol Chem. 1998;273:2260-72 pubmed
    ..This also suggests why in contrast to IgG Fc, the IgA1 N-glycans are not undergalactosylated in rheumatoid arthritis. ..
  65. Komiyama T, Ogura A, Hirokawa T, Zhijing M, Kamiguchi H, Asai S, et al. Analysis to Estimate Genetic Variations in the Idarubicin-Resistant Derivative MOLT-3. Int J Mol Sci. 2016;18: pubmed publisher
    ..Moreover, we identified five candidate genes harboring genetic alterations, including GALNT2, via CGH array analysis...
  66. Serino G, Sallustio F, Curci C, Cox S, Pesce F, De Palma G, et al. Role of let-7b in the regulation of N-acetylgalactosaminyltransferase 2 in IgA nephropathy. Nephrol Dial Transplant. 2015;30:1132-9 pubmed publisher
    ..the process is catalysed by UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2)...
  67. de Las Rivas M, Lira Navarrete E, Daniel E, Compañón I, Coelho H, Diniz A, et al. The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. Nat Commun. 2017;8:1959 pubmed publisher
    ..This work for the first time provides the structural basis for the different remote prior glycosylation preferences of the GalNAc-Ts. ..
  68. Bennett E, Hassan H, Clausen H. cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3. J Biol Chem. 1996;271:17006-12 pubmed
    ..Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3. ..
  69. Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna A, et al. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. Circ Cardiovasc Genet. 2012;5:242-9 pubmed publisher
    ..We found little evidence for pleiotropy linking dyslipidemia and obesity to the other MetS component traits, such as hypertension and glucose intolerance. ..
  70. Perrine C, Ganguli A, Wu P, Bertozzi C, Fritz T, Raman J, et al. Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. J Biol Chem. 2009;284:20387-97 pubmed publisher
    ..Our results reveal that these transferases have unique peptide and glycopeptide preferences demonstrating their substrate diversity and their likely roles ranging from initiating transferases to filling-in transferases. ..
  71. Guo T, Yin R, Huang F, Yao L, Lin W, Pan S. Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels. Sci Rep. 2016;6:19079 pubmed publisher
    ..proprotein convertase subtilisin/kexin type 9 (PCSK9) and polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) and serum lipid levels. Genotyping of 9 SNPs was performed in 881 Jing subjects and 988 Han participants...
  72. Hua D, Shen L, Xu L, Jiang Z, Zhou Y, Yue A, et al. Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancer. Int J Mol Med. 2012;30:1267-74 pubmed publisher
    ..These results indicate that ppGalNAc?T2 may be used as a novel therapeutic target for human gastric cancer treatment. ..