GalNAc T13

Summary

Gene Symbol: GalNAc T13
Description: polypeptide N-acetylgalactosaminyltransferase 13
Alias: GalNAc-T13, polypeptide N-acetylgalactosaminyltransferase 13, GalNAc transferase 13, UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 13, UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13), polypeptide GalNAc transferase 13, polypeptide N-acetylgalactosaminyltransferase 13 variant delta39bpEx9, polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx2-7, polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx6 delta39bpEx9, polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx6 deltaEx8 delta39bpEx9, polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx8, polypeptide N-acetylgalactosaminyltransferase 13 variant deltaEx9, pp-GaNTase 13, protein-UDP acetylgalactosaminyltransferase 13
Species: human
Products:     GalNAc T13

Top Publications

  1. Potus F, Hindmarch C, Dunham Snary K, Stafford J, Archer S. Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic Abnormalities. Int J Mol Sci. 2018;19: pubmed publisher
    ..Transcriptomics reveals the molecular fingerprint of RVF to be heavily characterized by mitochondrial dysfunction, fibrosis and inflammation. ..
  2. Ahmetov I, Fedotovskaya O. Current Progress in Sports Genomics. Adv Clin Chem. 2015;70:247-314 pubmed publisher
  3. Borowska A, Szwaczkowski T, Kaminski S, Hering D, Kordan W, Lecewicz M. Identification of genome regions determining semen quality in Holstein-Friesian bulls using information theory. Anim Reprod Sci. 2018;192:206-215 pubmed publisher
    ..Some detected clusters of SNPs were located in RNA (U6 and 5S_rRNA) for all the variables for which analysis occurred. Associations between PARK2 as well GALNT13 genes and some semen characteristics were also detected. ..
  4. de Jong K, Vonk J, Timens W, Bossé Y, Sin D, Hao K, et al. Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels. J Allergy Clin Immunol. 2015;136:1664-1672.e14 pubmed publisher
    ..Further research should determine whether the identified genes are true susceptibility loci for occupational exposures and whether these SNP-by-exposure interactions consequently contribute to the development of COPD. ..
  5. Vaiana C, Kurćon T, Mahal L. MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression. J Biol Chem. 2016;291:1529-37 pubmed publisher
    ..This work provides insight into the regulation of cell cycle progression by specific N-glycan branching patterns. ..
  6. Zhang Y, Iwasaki H, Wang H, Kudo T, Kalka T, Hennet T, et al. Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen. J Biol Chem. 2003;278:573-84 pubmed
    ..pp-GalNAc-T13 would be a major enzyme responsible for the synthesis of O-glycan and specifically the Tn antigen epitope in neurons. ..
  7. Raman J, Guan Y, Perrine C, Gerken T, Tabak L. UDP-N-acetyl-?-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Glycobiology. 2012;22:768-77 pubmed publisher
    ..Our findings provide a comprehensive view of the complexities of mucin-type O-glycan formation and provide insight into the underlying mechanisms employed to heavily decorate mucins and mucin-like domains with carbohydrate. ..
  8. Desai A, Zhou T, Ahmad H, Zhang W, Mu W, Trevino S, et al. A novel molecular signature for elevated tricuspid regurgitation velocity in sickle cell disease. Am J Respir Crit Care Med. 2012;186:359-68 pubmed publisher
    ..These studies validate the clinical usefulness of genomic signatures as potential biomarkers and highlight ADORA2B and GALNT13 as potential candidate genes in SCD-associated elevated TRV. ..
  9. Namjou B, Keddache M, Marsolo K, Wagner M, Lingren T, Cobb B, et al. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. Front Genet. 2013;4:268 pubmed publisher
    ..In addition, our data indicate that genetic variants in the first intron of FTO, a known adult genetic risk factor for BMI, are also robustly associated with BMI in pediatric population. ..

More Information

Publications14

  1. Festari M, Trajtenberg F, Berois N, Pantano S, Revoredo L, Kong Y, et al. Revisiting the human polypeptide GalNAc-T1 and T13 paralogs. Glycobiology. 2017;27:140-153 pubmed publisher
    ..In summary, the GalNAc-T13 isoform is predicted to function similarly to GalNAc-T1 against peptide substrates in vivo, in contrast to a prior report, but is unique by being selectively expressed in the brain. ..
  2. Lunetta K, D Agostino R, Karasik D, Benjamin E, Guo C, Govindaraju R, et al. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. BMC Med Genet. 2007;8 Suppl 1:S13 pubmed
    ..None of the associations achieved genome-wide significance. These data generate hypotheses and serve as a resource for replication as more genes and biologic pathways are proposed as contributing to longevity and healthy aging. ..
  3. Hussain M, Nasir J, Al Aama J. Clinically significant missense variants in human GALNT3, GALNT8, GALNT12, and GALNT13 genes: intriguing in silico findings. J Cell Biochem. 2014;115:313-27 pubmed publisher
  4. Park T, Hwang J, Go M, Lee H, Jang H, Choi Y, et al. Genome-wide association study of liver enzymes in korean children. Genomics Inform. 2013;11:149-54 pubmed publisher
  5. Nogimori K, Hori T, Kawaguchi K, Fukui T, Mii S, Nakada H, et al. Increased expression levels of ppGalNAc-T13 in lung cancers: Significance in the prognostic diagnosis. Int J Oncol. 2016;49:1369-76 pubmed publisher
    ..In conclusion, our results suggest that ppGalNAc-T13 might be a useful prognostic factor of lung cancers. ..