galectin

Summary

Gene Symbol: galectin
Description: galectin 1
Alias: GAL1, GBP, galectin-1, 14 kDa laminin-binding protein, 14 kDa lectin, HBL, HLBP14, HPL, S-Lac lectin 1, beta-galactoside-binding lectin L-14-I, beta-galactoside-binding protein 14kDa, gal-1, galaptin, lactose-binding lectin 1, lectin, galactoside-binding, soluble, 1
Species: human
Products:     galectin

Top Publications

  1. Iida A, Ozaki K, Tanaka T, Nakamura Y. Fine-scale SNP map of an 11-kb genomic region at 22q13.1 containing the galectin-1 gene. J Hum Genet. 2005;50:42-5 pubmed
    ..analyses, we previously showed that a functional single nucleotide polymorphism (SNP) in the gene encoding galectin-2 (lectin, galactoside-binding, soluble, 2; LGALS2) is associated with susceptibility to myocardial infarction...
  2. Hsieh S, Ying N, Wu M, Chiang W, Hsu C, Wong T, et al. Galectin-1, a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells. Oncogene. 2008;27:3746-53 pubmed publisher
    b>Galectin-1 (Gal-1), a homodimeric prototype of the galectins with a single carbohydrate-recognition domain, was recently identified as being overexpressed in tumor-associated capillary endothelial cells...
  3. Bi S, Earl L, Jacobs L, Baum L. Structural features of galectin-9 and galectin-1 that determine distinct T cell death pathways. J Biol Chem. 2008;283:12248-58 pubmed publisher
    The galectin family of lectins regulates multiple biologic functions, such as development, inflammation, immunity, and cancer. One common function of several galectins is the ability to trigger T cell death...
  4. Park J, Voss P, Grabski S, Wang J, Patterson R. Association of galectin-1 and galectin-3 with Gemin4 in complexes containing the SMN protein. Nucleic Acids Res. 2001;29:3595-602 pubmed
    In previous studies we showed that galectin-1 and galectin-3 are factors required for the splicing of pre-mRNA, as assayed in a cell-free system...
  5. Stowell S, Cho M, Feasley C, Arthur C, Song X, Colucci J, et al. Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation. J Biol Chem. 2009;284:4989-99 pubmed publisher
    b>Galectin-1 (Gal-1) regulates leukocyte turnover by inducing the cell surface exposure of phosphatidylserine (PS), a ligand that targets cells for phagocytic removal, in the absence of apoptosis...
  6. Rodig S, Ouyang J, Juszczynski P, Currie T, Law K, Neuberg D, et al. AP1-dependent galectin-1 expression delineates classical hodgkin and anaplastic large cell lymphomas from other lymphoid malignancies with shared molecular features. Clin Cancer Res. 2008;14:3338-44 pubmed publisher
    b>Galectin-1 (Gal1) is an immunomodulatory glycan-binding protein regulated by an AP1-dependent enhancer in Hodgkin Reed-Sternberg cells...
  7. Horiguchi N, Arimoto K, Mizutani A, Endo Ichikawa Y, Nakada H, Taketani S. Galectin-1 induces cell adhesion to the extracellular matrix and apoptosis of non-adherent human colon cancer Colo201 cells. J Biochem. 2003;134:869-74 pubmed
    ..Four positive clones were isolated and, when sequenced, one was found to be galectin-1, a beta-galactoside-binding protein...
  8. Nishi N, Abe A, Iwaki J, Yoshida H, Itoh A, Shoji H, et al. Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1. Glycobiology. 2008;18:1065-73 pubmed publisher
    b>Galectin-1 (Gal-1), a member of the beta-galactoside-binding animal lectin family, has a wide range of biological activities, which makes it an attractive target for medical applications...
  9. Kadri T, Lataillade J, Doucet C, Marie A, Ernou I, Bourin P, et al. Proteomic study of Galectin-1 expression in human mesenchymal stem cells. Stem Cells Dev. 2005;14:204-12 pubmed
    ..b>Galectin 1 (Gal1) belongs to a family of structurally related molecules expressed in many vertebrate tissues that exert ..

More Information

Publications93

  1. Kim H, Jeon H, Cho Y, Park Y, Choi J, Do I, et al. High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion. Eur J Cancer. 2012;48:1914-21 pubmed publisher
    b>Galectin-1 (Gal-1) is a 14-kDa laminin-binding galectin involved in several biological events including regulation of tumour proliferation and metastasis...
  2. Wiest I, Seliger C, Walzel H, Friese K, Jeschke U. Induction of apoptosis in human breast cancer and trophoblast tumor cells by galectin-1. Anticancer Res. 2005;25:1575-80 pubmed
    b>Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, preferentially recognizes Galbeta1-4GlcNAc (LacNAc) sequences of oligosaccharides associated with several cell surface glycoconjugates...
  3. Fajka Boja R, Blasko A, Kovács Sólyom F, Szebeni G, Toth G, Monostori E. Co-localization of galectin-1 with GM1 ganglioside in the course of its clathrin- and raft-dependent endocytosis. Cell Mol Life Sci. 2008;65:2586-93 pubmed publisher
    Mammalian galectin-1 (Gal-1), a beta-galactoside-binding lectin has a prominent role in regulating cell adhesion, cell growth and immune responses. Downregulation of these biological functions may occur via internalization of Gal-1...
  4. Wu M, Hong H, Hong T, Chiang W, Jin Y, Chen Y. Targeting galectin-1 in carcinoma-associated fibroblasts inhibits oral squamous cell carcinoma metastasis by downregulating MCP-1/CCL2 expression. Clin Cancer Res. 2011;17:1306-16 pubmed publisher
    ..The relationship between the expression of Galectin-1 (Gal-1) and alpha-smooth muscle actin (?-SMA, a CAF marker) in OSCC patient samples and primary cultured CAFs ..
  5. Espelt M, Croci D, Bacigalupo M, Carabias P, Manzi M, Elola M, et al. Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth. Hepatology. 2011;53:2097-106 pubmed publisher
    b>Galectin-1 (Gal-1), a widely expressed ?-galactoside-binding protein, exerts pleiotropic biological functions. Gal-1 is up-regulated in hepatocarcinoma cells, although its role in liver pathophysiology remains uncertain...
  6. Zhao X, Chen T, Xia L, Guo M, Xu Y, Yue F, et al. Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis. 2010;31:1367-75 pubmed publisher
    The expression of galectin-1, one of the most important lectins participating in the malignant tumor development, has been shown to be regulated by hypoxia, but its exact mechanism remains elusive...
  7. Baum L, Pang M, Perillo N, Wu T, Delegeane A, Uittenbogaart C, et al. Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells. J Exp Med. 1995;181:877-87 pubmed
    ..We found that human thymic epithelial cells synthesize an endogenous lectin, galectin-1, which binds to oligosaccharide ligands on the surface of thymocytes and T lymphoblastoid cells...
  8. Jung T, Jung S, Ryu H, Jeong Y, Jin Y, Jin S, et al. Role of galectin-1 in migration and invasion of human glioblastoma multiforme cell lines. J Neurosurg. 2008;109:273-84 pubmed publisher
    b>Galectin-1 is highly expressed in motile cell lines...
  9. Saussez S, Decaestecker C, Lorfevre F, Chevalier D, Mortuaire G, Kaltner H, et al. Increased expression and altered intracellular distribution of adhesion/growth-regulatory lectins galectins-1 and -7 during tumour progression in hypopharyngeal and laryngeal squamous cell carcinomas. Histopathology. 2008;52:483-93 pubmed publisher
    ..b>Galectin-1 positivity expressed as a percentage of cells was significantly higher in carcinomas (HSCCs and LSCCs) than in ..
  10. Chen R, Pan S, Ottenhof N, de Wilde R, Wolfgang C, Lane Z, et al. Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma. Cancer Biol Ther. 2012;13:899-907 pubmed publisher
    ..STS patients. Specifically, the expression of galectin-1 was 2-fold lower in VLTS compared with STS tumors...
  11. Pacienza N, Pozner R, Bianco G, D Atri L, Croci D, Negrotto S, et al. The immunoregulatory glycan-binding protein galectin-1 triggers human platelet activation. FASEB J. 2008;22:1113-23 pubmed
    Platelet activation is a critical process during inflammation, thrombosis, and cancer. Here, we show that galectin-1, an endogenous lectin with immunoregulatory properties, plays a key role in human platelet activation and function...
  12. Gauthier S, Pelletier I, Ouellet M, Vargas A, Tremblay M, Sato S, et al. Induction of galectin-1 expression by HTLV-I Tax and its impact on HTLV-I infectivity. Retrovirology. 2008;5:105 pubmed publisher
    ..Other factors might thus importantly contribute in increasing infection by HTLV-I. Galectin-1 is a galactoside-binding lectin which is secreted by activated T lymphocytes...
  13. St Pierre C, Manya H, Ouellet M, Clark G, Endo T, Tremblay M, et al. Host-soluble galectin-1 promotes HIV-1 replication through a direct interaction with glycans of viral gp120 and host CD4. J Virol. 2011;85:11742-51 pubmed publisher
    ..b>Galectin-1, a soluble lectin found in the underlayers of the epithelium, increases HIV-1 infectivity by accelerating its ..
  14. Fischer I, Schulze S, Kuhn C, Friese K, Walzel H, Markert U, et al. Inhibiton of RET and JAK2 signals and upregulation of VEGFR3 phosphorylation in vitro by galectin-1 in trophoblast tumor cells BeWo. Placenta. 2009;30:1078-82 pubmed publisher
    b>Galectin-1 (gal-1), a member of the mammalian beta-galactoside-binding proteins, binds to cell surface glycoproteins (Mucin-1) on trophoblast cells...
  15. Moiseeva E, Williams B, Samani N. Galectin 1 inhibits incorporation of vitronectin and chondroitin sulfate B into the extracellular matrix of human vascular smooth muscle cells. Biochim Biophys Acta. 2003;1619:125-32 pubmed
    b>Galectin-1, a beta-galactoside-binding dimeric lectin, interacts with the extracellular matrix (ECM) of smooth muscle cells (SMCs) and with particular ECM proteins...
  16. Camby I, Belot N, Lefranc F, Sadeghi N, De Launoit Y, Kaltner H, et al. Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases. J Neuropathol Exp Neurol. 2002;61:585-96 pubmed
    We show that high-grade astrocytic tumors with high levels of galectin-1 expression are associated with dismal prognoses...
  17. Levroney E, Aguilar H, Fulcher J, Kohatsu L, Pace K, Pang M, et al. Novel innate immune functions for galectin-1: galectin-1 inhibits cell fusion by Nipah virus envelope glycoproteins and augments dendritic cell secretion of proinflammatory cytokines. J Immunol. 2005;175:413-20 pubmed
    b>Galectin-1 (gal-1), an endogenous lectin secreted by a variety of cell types, has pleiotropic immunomodulatory functions, including regulation of lymphocyte survival and cytokine secretion in autoimmune, transplant disease, and parasitic ..
  18. Salomonsson E, Larumbe A, Tejler J, Tullberg E, Rydberg H, Sundin A, et al. Monovalent interactions of galectin-1. Biochemistry. 2010;49:9518-32 pubmed publisher
    b>Galectin-1, a ?-galactoside binding lectin involved in immunoregulation and cancer, binds natural and many synthetic multivalent glycoconjugates with an apparent glycoside cluster effect, that is, affinity above and beyond what would be ..
  19. Perillo N, Pace K, Seilhamer J, Baum L. Apoptosis of T cells mediated by galectin-1. Nature. 1995;378:736-9 pubmed
    b>Galectin-1, a member of the family of beta-galactoside binding proteins, has growth regulatory and immunomodulatory activities...
  20. Reynolds J, Law W, Mahajan S, Aalinkeel R, Nair B, Sykes D, et al. Nanoparticle based galectin-1 gene silencing, implications in methamphetamine regulation of HIV-1 infection in monocyte derived macrophages. J Neuroimmune Pharmacol. 2012;7:673-85 pubmed publisher
    b>Galectin-1, an adhesion molecule, is expressed in macrophages and implicated in human immunodeficiency virus (HIV-1) viral adsorption...
  21. Hsu Y, Wu C, Hung J, Lin Y, Huang M, Kuo P. Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin ?6?4 and Notch1/Jagged2 signaling pathway. Carcinogenesis. 2013;34:1370-81 pubmed publisher
    ..b>Galectin-1, a glycan-binding protein, has been shown to be overexpressed in lung cancer and involved in tumor-mediated ..
  22. Wang L, Friess H, Zhu Z, Frigeri L, Zimmermann A, Korc M, et al. Galectin-1 and galectin-3 in chronic pancreatitis. Lab Invest. 2000;80:1233-41 pubmed
    b>Galectin-1 and galectin-3 have important functions in cell-cell interactions, cell adhesion to extracellular matrix, the organization of extracellular matrix, and tissue remodeling...
  23. Croci D, Salatino M, Rubinstein N, Cerliani J, Cavallin L, Leung H, et al. Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma. J Exp Med. 2012;209:1985-2000 pubmed publisher
    ..We show that interactions between the regulatory lectin galectin-1 (Gal-1) and specific target N-glycans link tumor hypoxia to neovascularization as part of the pathogenesis of ..
  24. Gonzalez M, Rubinstein N, Ilarregui J, Toscano M, Sanjuan N, Rabinovich G. Regulated expression of galectin-1 after in vitro productive infection with herpes simplex virus type 1: implications for T cell apoptosis. Int J Immunopathol Pharmacol. 2005;18:615-23 pubmed
    ..b>Galectin-1 (Gal-1), an endogenous lectin involved in T-cell apoptosis, has recently gained considerable attention as a ..
  25. Szebeni G, Kriston Pál É, Blazso P, Katona R, Novák J, Szabó E, et al. Identification of galectin-1 as a critical factor in function of mouse mesenchymal stromal cell-mediated tumor promotion. PLoS ONE. 2012;7:e41372 pubmed publisher
    ..In the present study we have examined the role of galectin-1 (Gal-1), a protein highly expressed in tumors with poor prognosis, in MSCs in the course of tumor development...
  26. Matarrese P, Tinari A, Mormone E, Bianco G, Toscano M, Ascione B, et al. Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem. 2005;280:6969-85 pubmed
    ..Recent studies showed that galectin-1 (Gal-1) plays a key role in tumor-immune escape by killing antitumor effector T cells...
  27. Roda O, Ortiz Zapater E, Martínez Bosch N, Gutiérrez Gallego R, Vila Perello M, Ampurdanés C, et al. Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer. Gastroenterology. 2009;136:1379-90, e1-5 pubmed publisher
    ..The aim was to analyze the role of galectin-1 (Gal-1), an endogenous lectin that also is overexpressed in PDA, as a new functional receptor for tPA...
  28. Abbott W, Feizi T. Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene. Biochem J. 1989;259:291-4 pubmed
    ..The derived amino acid sequence is identical with that of the 14 kDa lectin from human placenta...
  29. Barondes S, Cooper D, Gitt M, Leffler H. Galectins. Structure and function of a large family of animal lectins. J Biol Chem. 1994;269:20807-10 pubmed
  30. Vicovac L, Jankovic M, Cuperlovic M. Galectin-1 and -3 in cells of the first trimester placental bed. Hum Reprod. 1998;13:730-5 pubmed
    The beta-galactoside-binding proteins galectin-1 and -3 are thought to modulate cell-extracellular matrix interactions in cell adhesion and migration. In this study, their occurrence in human trophoblast has been investigated...
  31. Pace K, Lee C, Stewart P, Baum L. Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1. J Immunol. 1999;163:3801-11 pubmed
    b>Galectin-1 induces apoptosis of human thymocytes and activated T cells by an unknown mechanism...
  32. Fouillit M, Joubert Caron R, Poirier F, Bourin P, Monostori E, Levi Strauss M, et al. Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells. Glycobiology. 2000;10:413-9 pubmed
    It has been well established that Galectin-1 (GAL1), a beta-galactoside-binding protein, regulates the viability of lymphoid cells. However, the signaling pathway governed by the binding of GAL1 to the cell membrane is not understood...
  33. Garner O, Aguilar H, Fulcher J, Levroney E, Harrison R, Wright L, et al. Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation. PLoS Pathog. 2010;6:e1000993 pubmed publisher
    ..We demonstrate that galectin-1 reduces NiV-F mediated fusion of endothelial cells, and that endogenous galectin-1 in endothelial cells is ..
  34. Mercier S, St Pierre C, Pelletier I, Ouellet M, Tremblay M, Sato S. Galectin-1 promotes HIV-1 infectivity in macrophages through stabilization of viral adsorption. Virology. 2008;371:121-9 pubmed
    ..Macrophages and other cells found at the infection site can secrete a soluble mammalian lectin, galectin-1, which binds to beta-galactoside residues through its carbohydrate recognition domain...
  35. Moiseeva E, Williams B, Goodall A, Samani N. Galectin-1 interacts with beta-1 subunit of integrin. Biochem Biophys Res Commun. 2003;310:1010-6 pubmed
    b>Galectin-1, a beta-galactoside-binding dimeric lectin, is involved in adhesion, migration, and proliferation of vascular smooth muscle cells (SMC), the key steps in the development of atherosclerosis and restenosis...
  36. Salomonsson E, Thijssen V, Griffioen A, Nilsson U, Leffler H. The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins. J Biol Chem. 2011;286:13801-4 pubmed publisher
    Angiogenesis is a key event in cancer progression and therefore a promising target in cancer treatment. Galectin-1, a ?-galactoside binding lectin, is up-regulated in the endothelium of tumors of different origin and has been shown to be ..
  37. Sakaguchi M, Shingo T, Shimazaki T, Okano H, Shiwa M, Ishibashi S, et al. A carbohydrate-binding protein, Galectin-1, promotes proliferation of adult neural stem cells. Proc Natl Acad Sci U S A. 2006;103:7112-7 pubmed
    ..In this screen, we identified a soluble carbohydrate-binding protein, Galectin-1, as a candidate...
  38. Hahn H, Pang M, He J, Hernandez J, Yang R, Li L, et al. Galectin-1 induces nuclear translocation of endonuclease G in caspase- and cytochrome c-independent T cell death. Cell Death Differ. 2004;11:1277-86 pubmed
    b>Galectin-1, a mammalian lectin expressed in many tissues, induces death of diverse cell types, including lymphocytes and tumor cells...
  39. Zhang P, Shi B, Zhou M, Jiang H, Zhang H, Pan X, et al. Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer. Cell Death Dis. 2014;5:e991 pubmed publisher
    This study was performed to investigate the role of galectin-1 (Gal-1) in epithelial ovarian cancer (EOC) progression and chemoresistance...
  40. Xue X, Lu Z, Tang D, Yao J, An Y, Wu J, et al. Galectin-1 secreted by activated stellate cells in pancreatic ductal adenocarcinoma stroma promotes proliferation and invasion of pancreatic cancer cells: an in vitro study on the microenvironment of pancreatic ductal adenocarcinoma. Pancreas. 2011;40:832-9 pubmed publisher
    ..aimed to clarify that the activated pancreatic stellate cells (PaSCs) are the origin of the highly expressed galectin-1 in the stroma of pancreatic ductal adenocarcinoma (PDAC) tissue and to evaluate the effect of the secreted ..
  41. Romaniuk M, Croci D, Lapponi M, Tribulatti M, Negrotto S, Poirier F, et al. Binding of galectin-1 to ?IIb?? integrin triggers "outside-in" signals, stimulates platelet activation, and controls primary hemostasis. FASEB J. 2012;26:2788-98 pubmed publisher
    ..We previously reported that galectin-1 (Gal-1), a ?-galactoside-binding protein, triggers platelet activation in vitro...
  42. Burns J, Kristiansen M, Kristensen L, Larsen K, Nielsen M, Christiansen H, et al. Decellularized matrix from tumorigenic human mesenchymal stem cells promotes neovascularization with galectin-1 dependent endothelial interaction. PLoS ONE. 2011;6:e21888 pubmed publisher
    ..characterization of the -BD11 decellularized matrix identified 50 extracellular angiogenic proteins, including galectin-1...
  43. Croci D, Cerliani J, Dalotto Moreno T, Méndez Huergo S, Mascanfroni I, Dergan Dylon S, et al. Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell. 2014;156:744-58 pubmed publisher
    ..Remodeling of the endothelial cell (EC) surface glycome selectively regulated binding of galectin-1 (Gal1), which upon recognition of complex N-glycans on VEGFR2, activated VEGF-like signaling...
  44. Than N, Romero R, Erez O, Weckle A, Tarca A, Hotra J, et al. Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance. Proc Natl Acad Sci U S A. 2008;105:15819-24 pubmed publisher
    b>Galectin-1 is an anti-inflammatory lectin with pleiotropic regulatory functions at the crossroads of innate and adaptive immunity...
  45. Fortin S, Le Mercier M, Camby I, Spiegl Kreinecker S, Berger W, Lefranc F, et al. Galectin-1 is implicated in the protein kinase C epsilon/vimentin-controlled trafficking of integrin-beta1 in glioblastoma cells. Brain Pathol. 2010;20:39-49 pubmed publisher
    ..In our current work we report that galectin-1, a homodimeric adhesion molecule and carbohydrate-binding protein with affinity for beta-galactosides, is ..
  46. Ouellet M, Mercier S, Pelletier I, Bounou S, Roy J, Hirabayashi J, et al. Galectin-1 acts as a soluble host factor that promotes HIV-1 infectivity through stabilization of virus attachment to host cells. J Immunol. 2005;174:4120-6 pubmed
    ..In this study, we report that galectin-1, a dimeric beta-galactoside-binding protein, promotes infection with R5, X4, and R5X4 variants...
  47. Jung E, Moon H, Cho B, Jeong C, Joo Y, Lee Y, et al. Galectin-1 expression in cancer-associated stromal cells correlates tumor invasiveness and tumor progression in breast cancer. Int J Cancer. 2007;120:2331-8 pubmed
    ..There was significant increase of galectin-1 expression in all cancerous tissues compared to noncancerous tissues, and its increased expression was further ..
  48. Sasaki T, Hirabayashi J, Manya H, Kasai K, Endo T. Galectin-1 induces astrocyte differentiation, which leads to production of brain-derived neurotrophic factor. Glycobiology. 2004;14:357-63 pubmed
    ..Here we report that galectin-1, a member of the family of beta-galactoside binding proteins, induces astrocyte differentiation and strongly ..
  49. He J, Baum L. Presentation of galectin-1 by extracellular matrix triggers T cell death. J Biol Chem. 2004;279:4705-12 pubmed
    ..T cell apoptosis can be initiated by a variety of triggers, including galectin-1, a soluble, secreted lectin that binds to oligosaccharide ligands on cell surface glycoproteins, or to ..
  50. Kondoh N, Hada A, Ryo A, Shuda M, Arai M, Matsubara O, et al. Activation of Galectin-1 gene in human hepatocellular carcinoma involves methylation-sensitive complex formations at the transcriptional upstream and downstream elements. Int J Oncol. 2003;23:1575-83 pubmed
    The expression of Galectin-1 (Gal-1) mRNA was activated in primary hepatocellular carcinomas (HCCs) compared to matched non-tumorous liver tissues...
  51. Delbrouck C, Doyen I, Belot N, Decaestecker C, Ghanooni R, de Lavareille A, et al. Galectin-1 is overexpressed in nasal polyps under budesonide and inhibits eosinophil migration. Lab Invest. 2002;82:147-58 pubmed
    ..by means of computer-assisted microscopy, 250 ng/ml (the highest dose tested) induced a pronounced increase of galectin-1 expression...
  52. Le Mercier M, Mathieu V, Haibe Kains B, Bontempi G, Mijatovic T, Decaestecker C, et al. Knocking down galectin 1 in human hs683 glioblastoma cells impairs both angiogenesis and endoplasmic reticulum stress responses. J Neuropathol Exp Neurol. 2008;67:456-69 pubmed publisher
    ..b>Galectin 1 signals through the endoplasmic reticulum transmembrane kinase/ribonuclease inositol-requiring 1alpha, which ..
  53. Paz A, Haklai R, Elad Sfadia G, Ballan E, Kloog Y. Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene. 2001;20:7486-93 pubmed
    ..contributes to inhibition of cell transformation we searched for new Ras-interacting proteins and identified galectin-1, a lectin implicated in human tumors, as a selective binding partner of oncogenic H-Ras(12V)...
  54. Kollár S, Sándor N, Molvarec A, Stenczer B, Rigo J, Tulassay T, et al. Prevalence of intracellular galectin-1-expressing lymphocytes in umbilical cord blood in comparison with adult peripheral blood. Biol Blood Marrow Transplant. 2012;18:1608-13 pubmed publisher
    ..b>Galectin-1 has strong immunosuppressive properties and plays a key role in the regulation of immune reactivity...
  55. Rubinstein N, Alvarez M, Zwirner N, Toscano M, Ilarregui J, Bravo A, et al. Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege. Cancer Cell. 2004;5:241-51 pubmed
    ..We demonstrate here that galectin-1 (Gal-1), a negative regulator of T cell activation and survival, plays a pivotal role in promoting escape from ..
  56. Sheng T, Rong L, Li Z, Bo J, Lei S. Tissue and serum galectin-1 expression in patients with colorectal carcinoma. Hepatogastroenterology. 2012;59:389-94 pubmed publisher
    To observe the expressing model of galectin-1 in colorectal carcinoma (CRC) progress. The expression of galectin-1 in peritumor, adenoma and CRC tissues using immunohistochemistry, western-blotting and RT-PCR was detected...
  57. Walzel H, Schulz U, Neels P, Brock J. Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45. Immunol Lett. 1999;67:193-202 pubmed
    b>Galectin-1 binds preferentially to N-acetyllactosamine residues on oligosaccharides associated with several cell surface glycoconjugates...
  58. Zhao X, Zhao K, Jiang Y, Zhao M, Chen G. Synergistic induction of galectin-1 by CCAAT/enhancer binding protein alpha and hypoxia-inducible factor 1alpha and its role in differentiation of acute myeloid leukemic cells. J Biol Chem. 2011;286:36808-19 pubmed publisher
    b>Galectin-1 is a member of the galectin family and has a high affinity for galactose and N-acetylglucosamine moieties of glycoproteins...
  59. Tang D, Yuan Z, Xue X, Lu Z, Zhang Y, Wang H, et al. High expression of Galectin-1 in pancreatic stellate cells plays a role in the development and maintenance of an immunosuppressive microenvironment in pancreatic cancer. Int J Cancer. 2012;130:2337-48 pubmed publisher
    b>Galectin-1 is implicated in making tumor cells immune privileged, in part by regulating the survival of infiltrating T cells...
  60. Baum L, Seilhamer J, Pang M, Levine W, Beynon D, Berliner J. Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation. Glycoconj J. 1995;12:63-8 pubmed
    The pattern of expression of an endogenous lectin, galectin-1, was examined in human lymphoid tissue...
  61. Stowell S, Karmakar S, Arthur C, Ju T, Rodrigues L, Riul T, et al. Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane. Mol Biol Cell. 2009;20:1408-18 pubmed publisher
    ..In contrast, neutrophils appear to possess apoptosis-independent mechanisms of removal. Here we show that Galectin-1 (Gal-1) induces PS exposure independent of alterations in mitochondrial potential, caspase activation, or cell ..
  62. Camby I, Decaestecker C, Lefranc F, Kaltner H, Gabius H, Kiss R. Galectin-1 knocking down in human U87 glioblastoma cells alters their gene expression pattern. Biochem Biophys Res Commun. 2005;335:27-35 pubmed
    ..i) progression of malignancy in patients bearing astrocytic tumors correlates with increased tumor levels of galectin-1; (ii) in vitro addition of purified galectin-1 to U87 human glioblastoma cells enhances tumor cell motility; ..
  63. Kamper P, Ludvigsen M, Bendix K, Hamilton Dutoit S, Rabinovich G, Møller M, et al. Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma. Blood. 2011;117:6638-49 pubmed publisher
    ..One of the differentially expressed proteins, the carbohydrate-binding protein galectin-1 (Gal-1), was further analyzed using immunohistochemistry HC and its expression was correlated with ..
  64. Kuo P, Hung J, Huang S, Chou S, Cheng D, Jong Y, et al. Lung cancer-derived galectin-1 mediates dendritic cell anergy through inhibitor of DNA binding 3/IL-10 signaling pathway. J Immunol. 2011;186:1521-30 pubmed publisher
    ..Evidence is provided in this paper supporting the role of lung cancer-derived soluble lectin, galectin-1, as a culprit in dendritic cell (DC) anergy...
  65. Satelli A, Rao U. Galectin-1 is silenced by promoter hypermethylation and its re-expression induces apoptosis in human colorectal cancer cells. Cancer Lett. 2011;301:38-46 pubmed publisher
    b>Galectin-1 (gal-1) is an important molecule secreted by many tumors, which induces apoptosis in activated T-cells and promotes tumor angiogenesis, both of which phenomena facilitate successful establishment of tumor in the body...
  66. Gieseke F, Böhringer J, Bussolari R, Dominici M, Handgretinger R, Müller I. Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells. Blood. 2010;116:3770-9 pubmed publisher
    ..Gene expression profiling of MSCs revealed that one of the most important lectins in this setting, galectin-1, was highly expressed. Galectin-1 protein was detected intracellularly and on the cell surface of MSCs...
  67. Abbott K, Matthews R, Pierce M. Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding. J Biol Chem. 2008;283:33026-35 pubmed publisher
    ..GnT-Vb-mediated glycosylation of RPTPbeta promotes galectin-1 binding and RPTPbeta levels of retention on the cell surface...
  68. Bektas S, Bahadir B, Ucan B, Ozdamar S. CD24 and galectin-1 expressions in gastric adenocarcinoma and clinicopathologic significance. Pathol Oncol Res. 2010;16:569-77 pubmed publisher
    CD24 and galectin-1 expression in gastric adenocarcinoma and their clinicopathologic significance remained largely unknown...
  69. Stowell S, Qian Y, Karmakar S, Koyama N, Dias Baruffi M, Leffler H, et al. Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol. 2008;180:3091-102 pubmed
    b>Galectin-1 (Gal-1) and galectin-3 (Gal-3) exhibit profound but unique immunomodulatory activities in animals but their molecular mechanisms are incompletely understood...
  70. Chung L, Tang S, Sun G, Chou T, Yeh T, Yu S, et al. Galectin-1 promotes lung cancer progression and chemoresistance by upregulating p38 MAPK, ERK, and cyclooxygenase-2. Clin Cancer Res. 2012;18:4037-47 pubmed
    This study is aimed at investigating the role and novel molecular mechanisms of galectin-1 in lung cancer progression...
  71. Sato S, Ouellet M, St Pierre C, Tremblay M. Glycans, galectins, and HIV-1 infection. Ann N Y Acad Sci. 2012;1253:133-48 pubmed publisher
    ..Recent works suggest that complex glycans of gp120 are recognized by another host lectin, galectin-1. This interaction results in rapid association of HIV-1 to susceptible cells and facilitates infection...
  72. Leppanen A, Stowell S, Blixt O, Cummings R. Dimeric galectin-1 binds with high affinity to alpha2,3-sialylated and non-sialylated terminal N-acetyllactosamine units on surface-bound extended glycans. J Biol Chem. 2005;280:5549-62 pubmed
    b>Galectin-1 is a member of the galectin family of glycan-binding proteins and occurs as an approximately 29.5-kDa noncovalent homodimer (dGal-1) that is widely expressed in many tissues...
  73. Cedeno Laurent F, Watanabe R, Teague J, Kupper T, Clark R, Dimitroff C. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012;119:3534-8 pubmed publisher
    Tumor-derived galectin-1 (Gal-1), a ?-galactoside-binding S-type lectin, has been shown to encourage T-cell death and promote T cell-mediated tumor immune escape...
  74. Sanchez Ruderisch H, Detjen K, Welzel M, Andre S, Fischer C, Gabius H, et al. Galectin-1 sensitizes carcinoma cells to anoikis via the fibronectin receptor ?5?1-integrin. Cell Death Differ. 2011;18:806-16 pubmed publisher
    ..Here, we show that treatment of anoikis-resistant carcinoma cell lines with the endogenous lectin galectin-1 (Gal-1) promoted apoptosis via interaction with the unligated fibronectin receptor ?(5)?(1)-integrin...
  75. Kuo P, Huang M, Cheng D, Hung J, Yang C, Chou S. Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. J Biol Chem. 2012;287:9753-64 pubmed publisher
    ..This study is the first to indicate that lung cancer-derived galectin-1 secretion is responsible for stimulating tumor-associated dendritic cells (TADCs) production of mature heparin-..
  76. Suzuki O, Hirsch B, Abe M, Dürkop H, Stein H. Galectin-1-mediated cell death is increased by CD30-induced signaling in anaplastic large cell lymphoma cells but not in Hodgkin lymphoma cells. Lab Invest. 2012;92:191-9 pubmed publisher
    ..By immunohistochemistry, we analyzed the expression of galectin-1 and galectin-3 in HL and ALCL cases as well as in cell lines, and investigated the pharmacological effects of ..
  77. Thijssen V, Postel R, Brandwijk R, Dings R, Nesmelova I, Satijn S, et al. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci U S A. 2006;103:15975-80 pubmed
    We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors...
  78. Wu H, Chen P, Liao R, Li Y, Yi Y, Wang J, et al. Overexpression of galectin-1 is associated with poor prognosis in human hepatocellular carcinoma following resection. J Gastroenterol Hepatol. 2012;27:1312-9 pubmed publisher
    The high expression of the galectin-1 predicts poor patient outcome in several tumors. The aim of this study was to investigate its prognostic value in patients with hepatocellular carcinoma (HCC) after resection...
  79. Toscano M, Campagna L, Molinero L, Cerliani J, Croci D, Ilarregui J, et al. Nuclear factor (NF)-?B controls expression of the immunoregulatory glycan-binding protein galectin-1. Mol Immunol. 2011;48:1940-9 pubmed publisher
    ..b>Galectin-1 (Gal-1), an endogenous lectin found in peripheral lymphoid organs and inflammatory sites, elicits a broad ..
  80. Spano D, Russo R, Di Maso V, Rosso N, Terracciano L, Roncalli M, et al. Galectin-1 and its involvement in hepatocellular carcinoma aggressiveness. Mol Med. 2010;16:102-15 pubmed publisher
    ..The expression analysis in humans of Galectin-1 (Gal-1), the protein encoded by LGALS1, showed a Gal-1 preferential accumulation in the stromal tissue around ..
  81. Andre S, Sanchez Ruderisch H, Nakagawa H, Buchholz M, Kopitz J, Forberich P, et al. Tumor suppressor p16INK4a--modulator of glycomic profile and galectin-1 expression to increase susceptibility to carbohydrate-dependent induction of anoikis in pancreatic carcinoma cells. FEBS J. 2007;274:3233-56 pubmed
    ..relevance in line with our hypothesis, we revealed differential reactivity towards endogenous lectins, especially galectin-1. As a result of reduced sialylation, the cells' capacity to bind galectin-1 was enhanced...
  82. Le Mercier M, Fortin S, Mathieu V, Roland I, Spiegl Kreinecker S, Haibe Kains B, et al. Galectin 1 proangiogenic and promigratory effects in the Hs683 oligodendroglioma model are partly mediated through the control of BEX2 expression. Neoplasia. 2009;11:485-96 pubmed
    We have previously reported that galectin 1 (Gal-1) plays important biological roles in astroglial as well as in oligodendroglial cancer cells...
  83. Ding Y, Dong J, Chen L, Zhang H. Increased expression of galectin-1 is associated with human oral squamous cell carcinoma development. Oncol Rep. 2009;21:983-7 pubmed
    b>Galectin-1 (Gal-1) is a newly found immunoregulatory carbohydrate-binding protein in cancer biology. The purpose of this study was to evaluate the effects of Gal-1 on oral squamous cell carcinoma (OSCC) development...
  84. Thijssen V, Griffioen A. Galectin-1 and -9 in angiogenesis: a sweet couple. Glycobiology. 2014;24:915-20 pubmed publisher
    ..We have previously reported on the role of galectin-1 and -9 in endothelial cell function...