Gene Symbol: galactosyltransferase
Description: beta-1,4-galactosyltransferase 1
Alias: B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1, beta-1,4-galactosyltransferase 1, UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1, UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1, beta-1,4-GalTase 1, glycoprotein-4-beta-galactosyltransferase 2, lactose synthase
Species: human
Products:     galactosyltransferase

Top Publications

  1. Ramakrishnan B, Qasba P. Crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I. J Mol Biol. 2001;310:205-18 pubmed
    The lactose synthase (LS) enzyme is a 1:1 complex of a catalytic component, beta1,4-galactosyltransferse (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA), a mammary gland-specific protein...
  2. Zhu X, Jiang J, Shen H, Wang H, Zong H, Li Z, et al. Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator. J Biol Chem. 2005;280:12503-16 pubmed
    The elevated levels of beta1,4-galactosyltransferase I (GalT I; EC are detected in highly metastatic lung cancer PGBE1 cells compared with its less metastatic partner PGLH7 cells...
  3. Brown J, Yang F, Sinha A, Ramakrishnan B, Tor Y, Qasba P, et al. Deoxygenated disaccharide analogs as specific inhibitors of beta1-4-galactosyltransferase 1 and selectin-mediated tumor metastasis. J Biol Chem. 2009;284:4952-9 pubmed publisher
    ..we show that GlcNAcbeta1-3Galbeta-O-naphthalenemethanol binds to the acceptor site of human beta1-4-galactosyltransferase much like the acceptor trisaccharide, GlcNAcbeta1-2Manbeta1-6Man, which is present on N-linked glycans...
  4. Poeta M, Massi E, Parrella P, Pellegrini P, De Robertis M, Copetti M, et al. Aberrant promoter methylation of beta-1,4 galactosyltransferase 1 as potential cancer-specific biomarker of colorectal tumors. Genes Chromosomes Cancer. 2012;51:1133-43 pubmed publisher
    ..In this study, we determined promoter methylation status of the glycogene beta-1,4-galactosyltransferase 1 (B4GALT1) in colorectal cancer patients...
  5. Choi H, Chung T, Kim C, Jeong H, Joo M, Youn B, et al. Estrogen induced ?-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cells. Biochem Biophys Res Commun. 2012;426:620-5 pubmed publisher
    Beta 1,4-galactosyltransferase 1 (B4GALT1) synthesizes galactose ?-1,4-N-acetylglucosamine (Gal?1-4GlcNAc) groups on N-linked sugar chains of glycoproteins, which play important roles in many biological events, including the ..
  6. Ramasamy V, Ramakrishnan B, Boeggeman E, Ratner D, Seeberger P, Qasba P. Oligosaccharide preferences of beta1,4-galactosyltransferase-I: crystal structures of Met340His mutant of human beta1,4-galactosyltransferase-I with a pentasaccharide and trisaccharides of the N-glycan moiety. J Mol Biol. 2005;353:53-67 pubmed
    beta-1,4-Galactosyltransferase-I (beta4Gal-T1) transfers galactose from UDP-galactose to N-acetylglucosamine (GlcNAc) residues of the branched N-linked oligosaccharide chains of glycoproteins...
  7. Han Y, Zhou X, Ji Y, Shen A, Sun X, Hu Y, et al. Expression of beta-1,4-galactosyltransferase-I affects cellular adhesion in human peripheral blood CD4+ T cells. Cell Immunol. 2010;262:11-7 pubmed publisher
    beta-1,4-galactosyltransferase-I (beta-1,4-GalT-I) has two isoforms that differ only in the length of their cytoplasmic domains...
  8. Amado M, Almeida R, Schwientek T, Clausen H. Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions. Biochim Biophys Acta. 1999;1473:35-53 pubmed
    ..strategies enabling the identification of these large glycosyltransferase gene families and exemplify the implication this has for our understanding of regulation of glycosylation by discussing two galactosyltransferase gene families.
  9. Wang J, Yang W, Chen Z, Chen J, Meng Y, Feng B, et al. Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis. Diabetes. 2018;67:581-593 pubmed publisher
    ..In conclusion, lncSHGL is a novel insulin-independent suppressor of hepatic gluconeogenesis and lipogenesis. Activating the lncSHGL/hnRNPA1 axis represents a potential strategy for the treatment of type 2 diabetes and steatosis. ..

More Information

Publications122 found, 100 shown here

  1. Hoffmann H, Trang C, Gong P, Kimura I, Pandolfi E, Mellon P. Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci. 2016;36:3506-18 pubmed publisher
    ..transcription, the capacity of VAX1 to regulate Gnrh1 transcription was evaluated in the GnRH cell lines GN11 and GT1-7...
  2. Bydlinski N, Maresch D, Schmieder V, Klanert G, Strasser R, Borth N. The contributions of individual galactosyltransferases to protein specific N-glycan processing in Chinese Hamster Ovary cells. J Biotechnol. 2018;282:101-110 pubmed publisher
    ..In view of our results, specifically engineered "designer" cell lines may be required for different proteins. ..
  3. Holm L, Krogvold L, Hasselby J, Kaur S, Claessens L, Russell M, et al. Abnormal islet sphingolipid metabolism in type 1 diabetes. Diabetologia. 2018;61:1650-1661 pubmed publisher
    ..xlsx?dl=0 . A list of SNPs identified is available at . ..
  4. Rorato R, Borges B, Uchoa E, Antunes Rodrigues J, Elias C, Elias L. LPS-Induced Low-Grade Inflammation Increases Hypothalamic JNK Expression and Causes Central Insulin Resistance Irrespective of Body Weight Changes. Int J Mol Sci. 2017;18: pubmed publisher
    ..transcription factor forkhead box protein O1 (FoxO1) from the nucleus to the cytoplasm of the cultured hypothalamic GT1-7 cells...
  5. Tanaka K, Shimoda M, Chuang V, Nishida K, Kawahara M, Ishida T, et al. Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity. Int J Pharm. 2018;535:140-147 pubmed publisher
    ..clearly suppress Cu2+/Zn2+-induced neuronal cell death in mouse hypothalamic neuronal cells (GT1-7 cells)...
  6. Hoffmann H, Mellon P. A small population of hypothalamic neurons govern fertility: the critical role of VAX1 in GnRH neuron development and fertility maintenance. Neurosci Commun (Houst). 2016;2: pubmed
    ..Finally, using the immortalized model GnRH neuron cell lines, GN11 and GT1-7, we show that VAX1 is a direct regulator of Gnrh1 transcription by binding key ATTA sites within the ..
  7. Ghumatkar P, Patil S, Jain P, Tambe R, Sathaye S. Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice. Pharmacol Biochem Behav. 2015;135:182-91 pubmed publisher
    ..Phloretin (PHL), a dihydrochalcone flavonoid usually present in the roots and leaves of apple tree. In vitro study on GT1-7 immortalized hypothalamic neurons exposed to amyloid beta (25-35), demonstrated that PHL significantly influenced ..
  8. Schmidt F, Zimmermann T, Wenz T, Schnorbus B, Ostad M, Feist C, et al. Interferon- and ribavirin-free therapy with new direct acting antivirals (DAA) for chronic hepatitis C improves vascular endothelial function. Int J Cardiol. 2018;271:296-300 pubmed publisher
    ..20 HCV patients (10 genotype GT1, 10 GT3) were treated with interferon (IFN)- and ribavirin (RBV)-free DAA regimens for 12 weeks (SVR12)...
  9. Lainez N, Coss D. Leukemia Inhibitory Factor Represses GnRH Gene Expression via cFOS during Inflammation in Male Mice. Neuroendocrinology. 2019;: pubmed publisher
    ..expression, herein we examined signaling pathways and mechanisms in males in vivo and in GnRH-expressing cell line, GT1-7...
  10. Deng J, Yuan F, Guo Y, Xiao Y, Niu Y, Deng Y, et al. Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure. Diabetes. 2017;66:640-650 pubmed publisher
    ..was directly regulated by ATF4 via binding to the cAMP-responsive element site on its promoter in hypothalamic GT1-7 cells...
  11. Qing S, Ji D, Li B, Li F, Wang Y, Niu X, et al. Improvement of glucose and lipid metabolism with pegylated interferon-a plus ribavirin therapy in Chinese patients chronically infected with genotype 1b hepatitis C virus. Ann Saudi Med. 2015;35:293-7 pubmed publisher
    ..a significant association between Type 2 diabetes mellitus and abnormal lipid profiles with chronic HCV genotype 1 (GT1) infection...
  12. Jiménez Sousa M, Berenguer J, Rallón N, Pineda Tenor D, Aldamiz Echevarría T, Soriano V, et al. IL15 polymorphism is associated with advanced fibrosis, inflammation-related biomarkers and virological response in human immunodeficiency virus/hepatitis C virus coinfection. Liver Int. 2016;36:1258-66 pubmed publisher
    ..12; P = 0.006), particularly in males (aOR = 3.69; P = 0.005), GT1/4 patients (aOR = 3.59; P = 0.006), patients with advanced fibrosis (aOR = 4.64; P = 0...
  13. Matta S, Patten K, Wang Q, Kim B, MacMicking J, Sibley L. NADPH Oxidase and Guanylate Binding Protein 5 Restrict Survival of Avirulent Type III Strains of Toxoplasma gondii in Naive Macrophages. MBio. 2018;9: pubmed publisher
    ..a time-dependent increase in intracellular ROS generation that was higher than that induced by type I parasites (GT1 strain)...
  14. Kumar G, Spurthi K, Kumar G, Aiyengar T, Chiranjeevi P, Nivas S, et al. Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients. Nitric Oxide. 2016;60:40-49 pubmed publisher
    ..786T/C, B-allele of Intron 4b/4a respectively) were associated with high nitrite/nitrate levels compared to GTB in both FDRS and CHD patients (p < 0.01)...
  15. Macchi C, Steffani L, Oleari R, Lettieri A, Valenti L, Dongiovanni P, et al. Iron overload induces hypogonadism in male mice via extrahypothalamic mechanisms. Mol Cell Endocrinol. 2017;454:135-145 pubmed publisher
    ..Even if iron challenge of in vitro neuronal models (GN-11 and GT1-7 GnRH cells) resulted in 10- and 5-fold iron content increments, respectively, no iron content changes were found ..
  16. Buti M, Domínguez Hernández R, Oyagüez I, Casado M, Esteban R. Cost-effectiveness analysis of ledipasvir/sofosbuvir in patients with chronic hepatitis C: Treatment of patients with absence or mild fibrosis compared to patients with advanced fibrosis. J Viral Hepat. 2017;24:750-758 pubmed publisher
    ..of ledipasvir/sofosbuvir (LDV/SOF) in treatment-naïve patients with chronic hepatitis C (CHC) genotype 1 (GT1) in the absence or mild fibrosis (F0-F1) versus advanced fibrosis (F2-F4), from the perspective of the Spanish ..
  17. de Winter B, Hesselink D, Kamar N. Dosing ribavirin in hepatitis E-infected solid organ transplant recipients. Pharmacol Res. 2018;130:308-315 pubmed publisher
    Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries...
  18. Saab S, Virabhak S, Parisé H, Johnson S, Wang A, Misurski D, et al. Cost-Effectiveness of Genotype 1 Chronic Hepatitis C Virus Treatments in Patients Coinfected with Human Immunodeficiency Virus in the United States. Adv Ther. 2016;33:1316-30 pubmed publisher
    ..This study estimated the cost-effectiveness of treatments for genotype 1 (GT1) HCV in HIV-coinfected patients. A Markov model based on HCV natural history was used...
  19. Chang T, Wu J, Wang T, Wu K, Chiang C. Uridine Diphosphate-Dependent Glycosyltransferases from Bacillus subtilis ATCC 6633 Catalyze the 15-O-Glycosylation of Ganoderic Acid A. Int J Mol Sci. 2018;19: pubmed publisher
    ..Five glycosyltransferase family 1 (GT1) genes of this bacterium, including two uridine diphosphate-dependent glycosyltransferase (UGT) genes, BsUGT398
  20. Fei Y, Xue Y, Du P, Yang S, Deng X. Expression analysis and promoter methylation under osmotic and salinity stress of TaGAPC1 in wheat (Triticum aestivum L). Protoplasma. 2017;254:987-996 pubmed publisher
    ..Several stress-related cis-acting elements (MBS, DRE, GT1 and LTR et al.) were located in its promoters...
  21. Subramani E, Madogwe E, Ray C, Dutta S, Chakravarty B, Bordignon V, et al. Dysregulated leukemia inhibitory factor and its receptor regulated signal transducers and activators of transcription 3 pathway: a possible cause for repeated implantation failure in women with dormant genital tuberculosis?. Fertil Steril. 2016;105:1076-1084.e5 pubmed publisher
    ..and LIF/LIFR-STAT3 signaling molecules expressed in the endometrium of women with dormant genital tuberculosis (GTB) during implantation window and measured also in HSP65-treated hESC...
  22. Sun Y, Yang Y, Qin Z, Cai J, Guo X, Tang Y, et al. The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway. Diabetes. 2016;65:1630-41 pubmed publisher able to bind directly to LepR and activate the receptor-mediated JAK2-STAT3 signaling in hypothalamus tissue and GT1-7 cells, which was derived from hypothalamic tumor...
  23. Crisà A, Ferré F, Chillemi G, Moioli B. RNA-Sequencing for profiling goat milk transcriptome in colostrum and mature milk. BMC Vet Res. 2016;12:264 pubmed
  24. van Scherpenzeel M, Steenbergen G, Morava E, Wevers R, Lefeber D. High-resolution mass spectrometry glycoprofiling of intact transferrin for diagnosis and subtype identification in the congenital disorders of glycosylation. Transl Res. 2015;166:639-649.e1 pubmed publisher
    ..mannosyl (α-1,6-)-glycoprotein β-1,2-N-acetylglucosaminyltransferase [MGAT2-CDG], β-1,4-galactosyltransferase 1 [B4GALT1-CDG], CMP-sialic acid transporter [SLC35A1-CDG], UDP-galactose transporter [SLC35A2-CDG] and ..
  25. Saxena V, Khungar V, Verna E, Levitsky J, Brown R, Hassan M, et al. Safety and efficacy of current direct-acting antiviral regimens in kidney and liver transplant recipients with hepatitis C: Results from the HCV-TARGET study. Hepatology. 2017;66:1090-1101 pubmed publisher
    ..Most had genotype (GT) 1 (87% with 52% GT1a, 27% GT1b, and 8% GT1 no subtype) and were treated with sofosbuvir (SOF)/ledipasvir ± ribavirin (85%) followed by SOF + daclatasvir ± ..
  26. Jensen K, Camejo A, Melo M, Cordeiro C, Julien L, Grotenbreg G, et al. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. MBio. 2015;6:e02280 pubmed publisher
    ..they are not protected against challenge with most strains prevalent in South America or another type I strain, GT1. Genetic and genomic analyses implicated the parasite-secreted rhoptry effectors ROP5 and ROP18, which antagonize ..
  27. Delboni M, Gomes B, Francisco P, Teixeira F, Drake D. Diversity of Enterococcus faecalis Genotypes from Multiple Oral Sites Associated with Endodontic Failure Using Repetitive Sequence-based Polymerase Chain Reaction and Arbitrarily Primed Polymerase Chain Reaction. J Endod. 2017;43:377-382 pubmed publisher
    ..faecalis controls. Seven different E. faecalis genotypes (GTs) (GT1 = 27%, GT2 = 17.6%, GT3 = 1.3%, GT4 = 18.9%, GT5 = 9.5%, GT6 = 14...
  28. Wang J, Chen Y, Chen Z, Xiang Z, Ding J, Han X. Microcystin-leucine arginine inhibits gonadotropin-releasing hormone synthesis in mice hypothalamus. Ecotoxicol Environ Saf. 2018;163:391-399 pubmed publisher
    ..With miRNA microarray analyses, we found that miR-329-3p was down-regulated most dramatically in MC-LR-treated GT1-7 cells...
  29. Yang W, Ma K, Qian Y, Zhang J, Feng G, Shi L, et al. Mitogen-activated protein kinase signaling pathways promote low-density lipoprotein receptor-related protein 1-mediated internalization of beta-amyloid protein in primary cortical neurons. Int J Biochem Cell Biol. 2015;64:252-64 pubmed publisher
    ..low-density lipoprotein receptor-related protein 1 (LRP1) mediates Aβ1-42 uptake and lysosomal trafficking in GT1-7 neuronal cells and mouse embryonic fibroblast non-neuronal cells...
  30. Rower J, Meissner E, Jimmerson L, Osinusi A, Sims Z, Petersen T, et al. Serum and cellular ribavirin pharmacokinetic and concentration-effect analysis in HCV patients receiving sofosbuvir plus ribavirin. J Antimicrob Chemother. 2015;70:2322-9 pubmed publisher
    ..Individuals infected with HCV genotype 1 (GT1) received 400 mg of sofosbuvir and either low-dose or weight-based ribavirin as part of the NIAID SPARE trial...
  31. Wang G, Terrault N, Reeves J, Liu L, Li E, Zhao L, et al. Prevalence and impact of baseline resistance-associated substitutions on the efficacy of ledipasvir/sofosbuvir or simeprevir/sofosbuvir against GT1 HCV infection. Sci Rep. 2018;8:3199 pubmed publisher
  32. Aqel B, Pungpapong S, Leise M, Werner K, Chervenak A, Watt K, et al. Multicenter experience using simeprevir and sofosbuvir with or without ribavirin to treat hepatitis C genotype 1 in patients with cirrhosis. Hepatology. 2015;62:1004-12 pubmed publisher
    ..response (SVR) rates along with minimal adverse events (AEs) in patients with hepatitis C genotype 1 (HCV GT1)...
  33. Kawano Yamashita E, Koyanagi M, Wada S, Tsukamoto H, Nagata T, Terakita A. Activation of Transducin by Bistable Pigment Parapinopsin in the Pineal Organ of Lower Vertebrates. PLoS ONE. 2015;10:e0141280 pubmed publisher
    ..that parapinopsin was colocalized with Gt2 in the teleost, which possesses rod and cone types of transducin, Gt1, and Gt2...
  34. Wei L, Han T, Yang D, Heo J, Shang J, Cheng J, et al. Simeprevir plus peginterferon/ribavirin for HCV genotype 1-infected treatment-naïve patients in China and South Korea. J Gastroenterol Hepatol. 2016;31:912-20 pubmed publisher
    ..pharmacokinetics, safety, and tolerability of simeprevir plus peginterferon alpha-2a and ribavirin (PR) in HCV GT1-infected, treatment-naïve, Asian patients with compensated liver disease...
  35. Huang P, Brusman L, Iyer A, Webster N, Mellon P. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS ONE. 2016;11:e0158597 pubmed publisher
    ..In immortalized mouse hypothalamic GnRH (GT1-7) neurons, which show pulsatile GnRH release in culture, RNA sequencing and RT-qPCR revealed that expression of a ..
  36. Subramani E, Jothiramajayam M, Dutta M, Chakravorty D, Joshi M, Srivastava S, et al. NMR-based metabonomics for understanding the influence of dormant female genital tuberculosis on metabolism of the human endometrium. Hum Reprod. 2016;31:854-65 pubmed publisher
    Does investigation of metabolic perturbations in endometrial tissue of women with dormant genital tuberculosis (GTB) during the window of implantation (WOI) assist in improving the understanding of endometrial receptivity? In dormant GTB ..
  37. Li Z, Wang Z, Huang S, Zhu X, Liu Q. TgERK7 is involved in the intracellular proliferation of Toxoplasma gondii. Parasitol Res. 2016;115:3419-24 pubmed publisher
    ..gondii is relevant to MAPK/ERK member, we created a mutant (?TgERK7) in GT1 tachyzoites using double homologous recombination method...
  38. Campana M, Bellini L, Rouch C, Rachdi L, Coant N, Butin N, et al. Inhibition of central de novo ceramide synthesis restores insulin signaling in hypothalamus and enhances β-cell function of obese Zucker rats. Mol Metab. 2018;8:23-36 pubmed publisher
    ..Hypothalamic GT1-7 neuronal cells were treated with palmitate...
  39. Kudo T, Narimatsu H. The beta 1,4-galactosyltransferase gene is post-transcriptionally regulated during differentiation of mouse F9 teratocarcinoma cells. Glycobiology. 1995;5:397-403 pubmed
    ..The mechanism of gene regulation of beta 1,4-galactosyltransferase (beta 1,4GalT), one of the glycosyltransferases involved in the synthesis of carbohydrate structures, was ..
  40. Akimoto Y, Obinata A, Endo H, Furukawa K, Aoki D, Nozawa S, et al. Immunocytochemical localization of the protein reactive to human beta-1, 4-galactosyltransferase antibodies during chick embryonic skin differentiation. Anat Rec. 1995;243:109-19 pubmed
    beta-1, 4-Galactosyltransferase (GalTase) transfers galactose from UDP-galactose to terminal N-acetylglucosamine in glycoconjugates and is located both in the Golgi apparatus and in the plasma membrane...
  41. Owens C, Brasher B, Polemeropoulos A, Rhodin M, McAllister N, Wong K, et al. Preclinical and Clinical Resistance Profile of EDP-239, a Novel Hepatitis C Virus NS5A Inhibitor. Antimicrob Agents Chemother. 2016;60:6216-26 pubmed publisher vitro and in vivo This study sought to characterize genotypic changes in the HCV NS5A sequence of genotype 1 (GT1) replicons and to compare those changes to GT1 viral RNA mutations isolated from clinical trial patients...
  42. Sperl J, Horvath G, Halota W, Ruiz Tapiador J, Streinu Cercel A, Jancoriene L, et al. Efficacy and safety of elbasvir/grazoprevir and sofosbuvir/pegylated interferon/ribavirin: A phase III randomized controlled trial. J Hepatol. 2016;65:1112-1119 pubmed publisher
    ..0% [95% CI, -35.5% to -19.6%; p<0.001]). EBR/GZR has a superior efficacy and safety profile in patients with HCV GT1 or 4 infection compared with SOF/PR...
  43. He X, Zhou S, St Armour G, Mackay T, Anholt R. Epistatic partners of neurogenic genes modulate Drosophila olfactory behavior. Genes Brain Behav. 2016;15:280-90 pubmed publisher
    ..We crossed the DGRP lines to P[GT1]-element insertion mutants in Sema-5c and neuralized (neur), two neurodevelopmental loci which affect olfactory ..
  44. Jackson W, Hanouneh M, Apfel T, Alkhouri N, John B, Zervos X, et al. Sofosbuvir and simeprevir without ribavirin effectively treat hepatitis C virus genotype 1 infection after liver transplantation in a two-center experience. Clin Transplant. 2016;30:709-13 pubmed publisher
    ..virologic response (SVR) rates with few adverse effects when treating patients with hepatitis C genotype 1 (HCV GT1) infection. However, there is scarcity of safety and efficacy data in this regimen after liver transplantation (LT)...
  45. Gane E, Poordad F, Wang S, Asatryan A, Kwo P, Lalezari J, et al. High Efficacy of ABT-493 and ABT-530 Treatment in Patients With HCV Genotype 1 or 3 Infection and Compensated Cirrhosis. Gastroenterology. 2016;151:651-659.e1 pubmed publisher
    ..phase 2 studies investigating the efficacy and safety of ABT-493 plus ABT-530 with or without ribavirin (RBV) in GT1- or GT3-infected patients with compensated cirrhosis...
  46. Hoffmann H, Gong P, Tamrazian A, Mellon P. Transcriptional interaction between cFOS and the homeodomain-binding transcription factor VAX1 on the GnRH promoter controls Gnrh1 expression levels in a GnRH neuron maturation specific manner. Mol Cell Endocrinol. 2018;461:143-154 pubmed publisher
    ..Using the GnRH cell lines, GN11 and GT1-7, we found that activation of PKC enhances expression of the immediate early gene cFos in both GN11, and GT1-7, ..
  47. Lo N, Shaper J, Pevsner J, Shaper N. The expanding beta 4-galactosyltransferase gene family: messages from the databanks. Glycobiology. 1998;8:517-26 pubmed
    From a systematic search of the UniGene and dbEST databanks, using human beta 4-galactosyltransferase (beta 4GalT-I), which is recognized to function in lactose biosynthesis, as the query sequence, we have identified five additional gene ..
  48. Reddy K, Lim J, Kuo A, Di Bisceglie A, Galati J, Morelli G, et al. All-oral direct-acting antiviral therapy in HCV-advanced liver disease is effective in real-world practice: observations through HCV-TARGET database. Aliment Pharmacol Ther. 2017;45:115-126 pubmed publisher
    ..Data from the 220 patients who completed 12-week follow-up were analysed. Genotype 1 (GT1) patients had higher sustained virological response (SVR) when treated with sofosbuvir plus simeprevir ± ribavirin ..
  49. Jamalidoust M, Namayandeh M, Moghadami M, Ziyaeyan M. Comparison of HCV viral load and its genotype distributions in HCV mono- and HIV/HCV co-infected illicit drug users. Virol J. 2017;14:127 pubmed publisher
    ..Given the higher baseline HCV viral load and GT1 attributed to poorer treatments response, HCV treatment must be more considered among HCV/HIV co-infected IDUs, ..
  50. Xu J, Lin S, Gao X, Nie Q, Luo Q, Zhang X. Mapping of Id locus for dermal shank melanin in a Chinese indigenous chicken breed. J Genet. 2017;96:977-983 pubmed
    ..3 (GRAMD3), aldehyde dehydrogenase 7 family member A1 (ALDH7A1), fem-1 homologue C (FEM1C), beta-1,4-galactosyltransferase 1 (B4GALT1) and versican (VCAN) genes were selected for the differential expression analysis...
  51. Paine S, Basu A, Choudhury R, Bhattacharya B, Chatterjee S, Bhattacharya C. Multiplex PCR from Menstrual Blood: A Non-Invasive Cost-Effective Approach to Reduce Diagnostic Dilemma for Genital Tuberculosis. Mol Diagn Ther. 2018;22:391-396 pubmed publisher
    Genital tuberculosis (GTB) is a potent contributor to irreversible damage to the reproductive system and infertility in females...
  52. Cremonesi P, Pozzi F, Raschetti M, Bignoli G, Capra E, Graber H, et al. Genomic characteristics of Staphylococcus aureus strains associated with high within-herd prevalence of intramammary infections in dairy cows. J Dairy Sci. 2015;98:6828-38 pubmed publisher
    ..Staphylococcus aureus strains isolated from 5 out of 8 HP herds showed a profile identical to the genotype B (GTB), described in previous studies as being strongly associated with high within-herd prevalence of Staph...
  53. Dore G, Conway B, Luo Y, Janczewska E, Knysz B, Liu Y, et al. Efficacy and safety of ombitasvir/paritaprevir/r and dasabuvir compared to IFN-containing regimens in genotype 1 HCV patients: The MALACHITE-I/II trials. J Hepatol. 2016;64:19-28 pubmed publisher
    ..Treatment-naïve (MALACHITE-I) or PegIFN/RBV-experienced (MALACHITE-II) non-cirrhotic, chronic HCV GT1-infected patients were randomized to OBV/PTV/r+DSV+weight-based RBV, OBV/PTV/r+DSV (treatment-naïve, GT1b-..
  54. Lee S, Kwak S, Kim D, Park S, Kim H, Kim Y, et al. Effects of Huang Bai (Phellodendri Cortex) and Three Other Herbs on GnRH and GH Levels in GT1-7 and GH3 Cells. Evid Based Complement Alternat Med. 2016;2016:9389028 pubmed publisher
    The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1-7 and GH3 cells...
  55. Younossi Z, Park H, Dieterich D, Saab S, Ahmed A, Gordon S. The value of cure associated with treating treatment-naïve chronic hepatitis C genotype 1: Are the new all-oral regimens good value to society?. Liver Int. 2017;37:662-668 pubmed publisher
    All-oral regimens are associated with high cure rates in hepatitis C virus-genotype 1 (HCV-GT1) patients. Our aim was to assess the value of cure to the society for treating HCV infection...
  56. Caudai C, Materazzi A, Saladini F, Di Giambenedetto S, Torti C, Ricciardi B, et al. Natural NS5A inhibitor resistance associated substitutions in hepatitis C virus genotype 1 infected patients from Italy. Clin Microbiol Infect. 2018;24:308.e5-308.e8 pubmed publisher
    ..was to detect NS5A inhibitor resistance associated substitutions (RASs) in hepatitis C virus (HCV) genotype 1 (GT1) patients who are naive to direct-acting HCV antivirals...
  57. Yamaguchi N, Fukuda M. Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins. J Biol Chem. 1995;270:12170-6 pubmed
    ..We show here that beta-1,4-galactosyltransferase (GT) forms homodimers and large oligomers in vivo, and the formation of the homodimers is dependent on ..
  58. Swann R, Cowton V, Robinson M, Cole S, Barclay S, Mills P, et al. Broad Anti-Hepatitis C Virus (HCV) Antibody Responses Are Associated with Improved Clinical Disease Parameters in Chronic HCV Infection. J Virol. 2016;90:4530-4543 pubmed publisher
    ..neutralization did not correlate with any clinical parameters; however, analysis of individuals with genotype 1 (gt1) HCV infection (n= 20), using an intragenotype pseudoparticle panel, found a strong association between ..
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    ..With its greater ear number, teosinte is referred to as being more prolific. The grassy tillers 1 (gt1) gene has been identified as a large-effect quantitative trait locus underlying this prolificacy difference between ..
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    ..In addition, knockdown of EGFL7 expression suppresses proliferation and invasion of GH3 and GT1-1 cells in vitro. Moreover, attenuation of EGFL7 inhibits human GHPA growth in vivo...
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    ..Our study highlights that skeletal and cardiac muscles are affected differently in the C26 mouse model of cachexia and that therapeutic strategies cannot assume that both muscle types will show a similar response. ..
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    b>Galactosyltransferase (EC, purified to homogeneity from human milk by affinity chromatography, had an apparent molecular weight of 53,000 as determined by denaturing polyacrylamide gel electrophoresis...
  63. Go E, Irungu J, Zhang Y, Dalpathado D, Liao H, Sutherland L, et al. Glycosylation site-specific analysis of HIV envelope proteins (JR-FL and CON-S) reveals major differences in glycosylation site occupancy, glycoform profiles, and antigenic epitopes' accessibility. J Proteome Res. 2008;7:1660-74 pubmed publisher
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    UDP-galactose: N-acetylglucosamine galactosyltransferase was isolated from pooled human milk, pooled amniotic fluid and from two different individual samples of malignant ascites...
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    Human milk galactosyltransferase (EC was purified to homogeneity using affinity chromatography. Edman degradation was used to determine the amino acid sequences of eight peptide fragments isolated from the purified enzyme...
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    ..The A protein has a molecular weight of about 40,000. Its interaction with alpha-lactalbumin in the presence of N-acetylglucosamine has been demonstrated by affinity chromatography and gel filtration. ..
  67. Tamura G, Nittayajarn A, Schoentag D. A glutamine transport gene, glnQ, is required for fibronectin adherence and virulence of group B streptococci. Infect Immun. 2002;70:2877-85 pubmed
    ..GBS adhere to fibronectin when it is attached to a solid phase. We isolated a Tn917 transposon mutant, COH1-GT1, which shows decreased adherence to fibronectin...
  68. Wei Y, Liu D, Zhou F, Ge Y, Xu J, Yun X, et al. Identification of beta-1,4-galactosyltransferase I as a target gene of HBx-induced cell cycle progression of hepatoma cell. J Hepatol. 2008;49:1029-37 pubmed publisher
    ..beta-1,4-galactosyltransferase I (GalT I) contributes to the biosynthesis of Galbeta-->4GlcNAc structure in the outer chain moieties ..
  69. Liu W, Cui Z, Wang Y, Zhu X, Fan J, Bao G, et al. Elevated expression of ?1,4-galactosyltransferase-I in cartilage and synovial tissue of patients with osteoarthritis. Inflammation. 2012;35:647-55 pubmed publisher
    ..These data suggest that ?1,4-GalT-I may play an important role in the inflammatory processes in cartilage and synovial tissue of patients with OA. ..
  70. Zhu F, Shen F, Fan Y, Xie Y, Xia Y, Kong Y. Osteopontin increases the expression of ?1, 4-galactosyltransferase-I and promotes adhesion in human RL95-2 cells. Glycoconj J. 2012;29:347-56 pubmed publisher
    Beta1, 4-Galactosyltransferase-I (?1, 4-GalT-I), which transfers galactose from UDP-Gal to N-acetylglucosamine and N-acetylglucosamine-terminated oligosaccharides of N- and O-linked glycans in a ?(1-4) linkage, plays a critical role in ..
  71. Manee N, Thongbaiphet N, Pasomsub E, Chantratita W. Clinical evaluation of a newly developed automated massively parallel sequencing assay for hepatitis C virus genotyping and detection of resistance-association variants. Comparison with a line probe assay. J Virol Methods. 2017;249:31-37 pubmed publisher
    ..67%). In addition, MPS could detect Resistance-Associated Variants (RAVs) simultaneously in GT1 in 56.82% of the specimens, which were known to affect drug resistance in the HCV NS3/NS4A and NS5A genomic regions...
  72. Bakker H, Rouwendal G, Karnoup A, Florack D, Stoopen G, Helsper J, et al. An antibody produced in tobacco expressing a hybrid beta-1,4-galactosyltransferase is essentially devoid of plant carbohydrate epitopes. Proc Natl Acad Sci U S A. 2006;103:7577-82 pubmed
    ..N-terminal domain of Arabidopsis thaliana xylosyltransferase and the catalytic domain of human beta-1,4-galactosyltransferase I (GalT), in tobacco causes a sharp reduction of N-glycans with potentially immunogenic core-bound xylose (..
  73. Li X, Li D, Pang X, Yang G, Deeg H, Guan F. Quantitative analysis of glycans, related genes, and proteins in two human bone marrow stromal cell lines using an integrated strategy. Exp Hematol. 2015;43:760-9.e7 pubmed publisher
    ..whereas HS27a cells had enhanced levels of Galβ1,4GlcNAc (catalyzed by β4GalT1 [β4-galactosyltransferase I])...
  74. Tan S, Adlin Nadia Z. The clinical features and treatment outcome of chronic hepatitis C with pegylated interferon and ribavirin in routine care. Med J Malaysia. 2017;72:165-174 pubmed
    ..1% of patients. The predominant HCV genotype (GT) was 3 at 60.6%, second was GT1 at 36.1% and other GTs were uncommon at about 1% or less...
  75. Dammermann W, Polywka S, Dettmann I, Mindorf S, Komorowski L, Wehmeyer M, et al. Autoantibodies against "rods and rings"-related IMPDH2 in hepatitis C genotype 1 and DAA therapy in a "real life" cohort. Med Microbiol Immunol. 2017;206:379-382 pubmed publisher
    ..We analyzed a "real life" cohort of 104 unselected CHC genotype 1 (GT1) patients treated with IFN/first-generation DAA/RBV prospectively compared to a historic cohort of 59 IFN/RBV-..
  76. Lortkipanidze G, Kintraia N, Vacharadze K, Tsaava F. [RISK FACTORS AND SPECIAL ASPECTS FORGENITAL TUBERCULOSIS DIAGNOSTICS]. Georgian Med News. 2017;:98-103 pubmed
    ..b>GTB was detected in 289 cases, in 164 cases GTB results was negative (control group)...
  77. Lawitz E, Yang J, Stamm L, Taylor J, Cheng G, Brainard D, et al. Characterization of HCV resistance from a 3-day monotherapy study of voxilaprevir, a novel pangenotypic NS3/4A protease inhibitor. Antivir Ther. 2017;: pubmed publisher
    ..protease inhibitor (PI) with potent antiviral activity against HCV genotypes (GTs) 1-6 and improved coverage of GT1 NS3 resistance-associated substitutions (RASs) associated with other HCV PIs...
  78. Li X, Yang Y, Zhan C, Zhang Z, Liu X, Liu H, et al. Transcriptional analysis of impacts of glycerol transporter 1 on methanol and glycerol metabolism in Pichia pastoris. FEMS Yeast Res. 2017;: pubmed publisher
    ..In the present study, the gene of a previously characterized transmembrane protein glycerol transporter 1 (GT1) of P. pastoris GS115 was deleted by homologous recombination...
  79. Krishnan P, Schnell G, Tripathi R, Beyer J, Reisch T, Dekhtyar T, et al. Integrated Resistance Analysis of CERTAIN-1 and CERTAIN-2 Studies in Hepatitis C Virus-Infected Patients Receiving Glecaprevir and Pibrentasvir in Japan. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..4%. Common baseline polymorphisms in NS3 and/or NS5A had no impact on treatment outcomes in GT1- and GT2-infected patients; the impact on GT3-infected patients could not be assessed due to the enrollment of ..
  80. Chatterjee S, Mukerjee S, Tripathi P. Analysis of the sequences of human beta-1,4-galactosyltransferase cDNA clones. Int J Biochem Cell Biol. 1995;27:329-36 pubmed
    UDP-galactose:beta-1,4 N-acetyl glucosamine galactosyltransferase (4 beta GT) is a promising tumor marker for ovarian cancer...
  81. García Vallejo J, van Dijk W, van Die I, Gringhuis S. Tumor necrosis factor-alpha up-regulates the expression of beta1,4-galactosyltransferase I in primary human endothelial cells by mRNA stabilization. J Biol Chem. 2005;280:12676-82 pubmed
    ..Our data show that TNFalpha induced an increase in the expression of beta1,4-galactosyltransferase-1 (beta4GalT-1) in primary human umbilical vein endothelial cells in a time- and concentration-dependent ..
  82. Li Z, Zong H, Kong X, Zhang S, Wang H, Sun Q, et al. Cell surface beta 1, 4-galactosyltransferase 1 promotes apoptosis by inhibiting epidermal growth factor receptor pathway. Mol Cell Biochem. 2006;291:69-76 pubmed
    ..These results demonstrated that cell surface beta1,4GT1 may negatively regulate cell survival possibly through inhibiting and modulating EGFR signaling pathway. ..
  83. Liu Y, Curlin M, Diem K, Zhao H, Ghosh A, Zhu H, et al. Env length and N-linked glycosylation following transmission of human immunodeficiency virus Type 1 subtype B viruses. Virology. 2008;374:229-33 pubmed publisher
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    ..The aim of this study was to evaluate GZR plus ribavirin (RBV) in patients with HCV GT1 infection...
  85. Zhou H, Ma H, Wei W, Ji D, Song X, Sun J, et al. B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog pathway and the expression of p-glycoprotein and multidrug resistance-associated protein 1. Cell Death Dis. 2013;4:e654 pubmed publisher
    1, 4-Galactosyltransferase gene (B4GALT) family consists of seven members, which encode corresponding enzymes known as type II membrane-bound glycoproteins...
  86. Sun X, Wu Y, Wang Y, Xue Q, Cheng X, Zhang G, et al. β-1,4-galactosyltransferase-I activates proliferation and participates in intercellular contacts of lymphocytes. Hum Immunol. 2014;75:1019-25 pubmed publisher
    Beta-1,4-galactosyltransferase I (β-1,4-GalT-I) mediates several biological mechanisms as a key enzyme in glycobiology, but the role of β-1,4-GalT-I in immune system remains unclear...
  87. Chen L, Xie Y, Fan J, Sui L, Xu Y, Zhang N, et al. HCG induces β1,4-GalT I expression and promotes embryo implantation. Int J Clin Exp Pathol. 2015;8:4673-83 pubmed
    ..Beta1, 4-Galactosyltransferase-I (β1,4-GalT-I) is ubiquitously expresses in human tissues with the exception of the brain...
  88. Ma S, Ding Z, Li P. Maize network analysis revealed gene modules involved in development, nutrients utilization, metabolism, and stress response. BMC Plant Biol. 2017;17:131 pubmed publisher
    ..Among them, the inflorescences development module is enriched with domestication genes (like ra1, ba1, gt1, tb1, tga1) that control plant architecture and kernel structure, while multiple other modules relate to diverse ..
  89. Furukawa K, Roth S, Sawicki J. Several galactosyltransferase activities are associated with mouse chromosome 17. Genetics. 1986;114:983-91 pubmed
    ..although ganglioside variations in mice are linked to the H-2 complex on chromosome 17, and one galactosyltransferase activity on mouse sperm varies with T/t complex genotypes, also on chromosome 17...
  90. Roth J, Lentze M, Berger E. Immunocytochemical demonstration of ecto-galactosyltransferase in absorptive intestinal cells. J Cell Biol. 1985;100:118-25 pubmed
    b>Galactosyltransferase immunoreactive sites were localized in human duodenal enterocytes by the protein A-gold technique on thin sections from low temperature Lowicryl K4M embedded biopsy specimens...
  91. Lee P, Kohler J, Pfeffer S. Association of beta-1,3-N-acetylglucosaminyltransferase 1 and beta-1,4-galactosyltransferase 1, trans-Golgi enzymes involved in coupled poly-N-acetyllactosamine synthesis. Glycobiology. 2009;19:655-64 pubmed publisher
    ..of UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) and UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 1 (B4GALT1), respectively...
  92. Tang W, Weng S, Zhang S, Wu W, Dong L, Shen X, et al. Direct interaction between surface ?1,4-galactosyltransferase 1 and epidermal growth factor receptor (EGFR) inhibits EGFR activation in hepatocellular carcinoma. Biochem Biophys Res Commun. 2013;434:449-54 pubmed publisher
    Our previous studies showed that cell surface ?1,4-galactosyltransferase 1 (?1,4GT1) negatively regulated cell survival through inhibition and modulation of the epidermal growth factor receptor (EGFR) signaling pathway in human ..