Gene Symbol: GAGE1
Description: G antigen 1
Alias: CT4.1, GAGE-1, G antigen 1, MZ2-F antigen, cancer/testis antigen 4.1, cancer/testis antigen family 4, member 1
Species: human
Products:     GAGE1

Top Publications

  1. Li Y, Hu J, Li L, Cai S, Zhang H, Zhu X, et al. Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis. Biochem Biophys Res Commun. 2018;503:2089-2094 pubmed publisher
    ..reporter assays were conducted to investigate the association between circ_0016760 and miR-1287 and miR-1287 and GAGE1. We found that circ_0016760 was enhanced in NSCLC tissues and cells and the upregulation of circ_0016760 is ..
  2. Vodolazhsky D, Kutilin D, Mogushkova K, Kit O. Specific Features of Transcription Activity of Cancer-Testis Antigens in Patients with Metastatic and Non-Metastatic Breast Cancer. Bull Exp Biol Med. 2018;165:382-385 pubmed publisher
    ..The relative expression of 16 genes (MAGEA1, MAGEA2, MAGEA3, MAGEA4, MAGEB1, MAGEB2, GAGE1, GAGE3, GAGE4, MAGEC1, BAGE, XAGE3, NY-ESO1, SSX2, SYCP1, and PRAME1) was analyzed by RT-qPCR method in biopsy ..
  3. Reardon E, Hong J, Straughan D, Azoury S, Zhang M, Schrump D. Pulmonary Metastases Exhibit Epigenetic Clonality: Implications for Precision Cancer Therapy. Ann Thorac Surg. 2015;100:1839-48; discussion 1848 pubmed publisher
    ..were used to evaluate expression levels of cancer-testis (CT) genes (NY-ESO-1, MAGE-A3, MAGE-A9, MAGE-A12, GAGE1, CT-45, SSX-1, and SSX-2), tumor suppressor (TS) genes (p16 and RASSF1A), and genes encoding epigenetic modifiers (..
  4. Oltra S, Martinez F, Orellana C, Grau E, Fernandez J, Canete A, et al. Minimal residual disease in neuroblastoma: to GAGE or not to GAGE. Oncol Res. 2004;14:291-5 pubmed
    ..We conclude that GAGE genes can show a variable, usually low level of illegitimate expression in normal blood cells, and therefore their use as MRD markers should be taken with caution. ..
  5. Atanackovic D, Blum I, Cao Y, Wenzel S, Bartels K, Faltz C, et al. Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. Cancer Biol Ther. 2006;5:1218-25 pubmed
    ..NY-TLU-57, GAGE1, SAGE1 were expressed more frequently in tumor samples than in healthy tissues...
  6. Zhang S, Zhou X, Yu H, Yu Y. Expression of tumor-specific antigen MAGE, GAGE and BAGE in ovarian cancer tissues and cell lines. BMC Cancer. 2010;10:163 pubmed publisher
    ..These genes can be used as one of the important indicators for early diagnosis, efficacy evaluation and prognostic determination of ovarian cancer. ..
  7. Nagel H, Laskawi R, Eiffert H, Schlott T. Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands. Mol Pathol. 2003;56:226-31 pubmed
    ..The tumour rejection genes were more frequently, but not exclusively, expressed in malignant salivary gland tumours than in benign neoplasms, although none was suitable as a diagnostic marker of malignancy in salivary gland neoplasms. ..
  8. Chen Z, Shao J, Wu W. Expression of A, G and B melanoma antigen genes in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2002;1:570-3 pubmed
    ..The MAGE-1,MAGE-3,GAGE1-8,GAGE1-2 and BAGE mRNA lever in hepatocellular carcinoma cell lines SMMC-7721, QQY-7701, BEL-7402 were studied by ..
  9. D Alessio A, Weaver I, Szyf M. Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes. Mol Cell Biol. 2007;27:7462-74 pubmed
    ..These data suggest that DNA demethylation follows rather than precedes early transcription and point towards a novel function for DNA demethylation as a memory of actively transcribed genes. ..

More Information


  1. Gjerstorff M, Kock K, Nielsen O, Ditzel H. MAGE-A1, GAGE and NY-ESO-1 cancer/testis antigen expression during human gonadal development. Hum Reprod. 2007;22:953-60 pubmed
    ..The recognition of differential cellular expression of GAGE, MAGE-A1, NY-ESO-1 and OCT4 may help define biologically distinct germ cell subpopulations. ..
  2. Mishra D, Chen Z, Wu Y, Sarkissyan M, Koeffler H, Vadgama J. Global methylation pattern of genes in androgen-sensitive and androgen-independent prostate cancer cells. Mol Cancer Ther. 2010;9:33-45 pubmed publisher
    ..addition, promoter methylation was detected for the first time in target genes such as RIOK3, STAT5, CASP8, SRBC, GAGE1, and NPAT...
  3. Jungbluth A, Silva W, Iversen K, Frosina D, Zaidi B, Coplan K, et al. Expression of cancer-testis (CT) antigens in placenta. Cancer Immun. 2007;7:15 pubmed
    ..However, our data indicate that the various CT antigens have different functions during placental development. ..
  4. Kong U, Koo J, Choi K, Park J, Chang H. The expression of GAGE gene can predict aggressive biologic behavior of intestinal type of stomach cancer. Hepatogastroenterology. 2004;51:1519-23 pubmed
  5. De Backer O, Arden K, Boretti M, Vantomme V, de Smet C, Czekay S, et al. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. Cancer Res. 1999;59:3157-65 pubmed
    ..Treatment of normal and tumor cultured cells with a demethylating agent, azadeoxycytidine, resulted in the transcriptional activation of GAGE genes, suggesting that their expression in tumors results from a demethylation process. ..
  6. Gjerstorff M, Ditzel H. An overview of the GAGE cancer/testis antigen family with the inclusion of newly identified members. Tissue Antigens. 2008;71:187-92 pubmed publisher
    ..The potential use of GAGE proteins in cancer immunotherapy, including possible limitations, is also discussed. ..
  7. Van den Eynde B, Peeters O, De Backer O, Gaugler B, Lucas S, Boon T. A new family of genes coding for an antigen recognized by autologous cytolytic T lymphocytes on a human melanoma. J Exp Med. 1995;182:689-98 pubmed
    ..About 50% of melanoma patients carry on their tumor at least one of the presently defined antigens encoded by the MAGE, BAGE, and GAGE genes. ..
  8. Chen M, Lin S, Chung L, Sikes R. Isolation and characterization of PAGE-1 and GAGE-7. New genes expressed in the LNCaP prostate cancer progression model that share homology with melanoma-associated antigens. J Biol Chem. 1998;273:17618-25 pubmed