GABRP

Summary

Gene Symbol: GABRP
Description: gamma-aminobutyric acid type A receptor pi subunit
Alias: gamma-aminobutyric acid receptor subunit pi, GABA(A) receptor subunit pi, GABA(A) receptor, pi, gamma-aminobutyric acid (GABA) A receptor, pi
Species: human
Products:     GABRP

Top Publications

  1. Lu J, Zhang Q, Tan D, Luo W, Zhao H, Ma J, et al. GABA A receptor ? subunit promotes apoptosis of HTR-8/SVneo trophoblastic cells: Implications in preeclampsia. Int J Mol Med. 2016;38:105-12 pubmed publisher
    ..The GABA type A receptor ? subunit (GABRP) has been identified in the tissues of the reproductive system, particularly in the uterus...
  2. Green E, Grozeva D, Moskvina V, Hamshere M, Jones I, Jones L, et al. Variation at the GABAA receptor gene, Rho 1 (GABRR1) associated with susceptibility to bipolar schizoaffective disorder. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1347-9 pubmed publisher
    ..Here we provide suggestive evidence implicating a sixth member of the gene family, GABRR1 (gene-wide P = 0.0058; experiment-wide corrected significance P = 0.052). ..
  3. Soggiu A, Piras C, Greco V, Devoto P, Urbani A, Calzetta L, et al. Exploring the neural mechanisms of finasteride: a proteomic analysis in the nucleus accumbens. Psychoneuroendocrinology. 2016;74:387-396 pubmed publisher
    ..spectrometry revealed significant changes in the expression of nine proteins (CRMP2, PSMD1, STX18, KCNC3, CYP255, GABRP, GABT, PRPS1, CYP2B3), which were further analyzed by ontological classification (PANTHER)...
  4. Hedblom E, Kirkness E. A novel class of GABAA receptor subunit in tissues of the reproductive system. J Biol Chem. 1997;272:15346-50 pubmed
    ..Identification of the pi subunit indicates a new target for pharmacological manipulation of GABAA receptors that are located outside of the central nervous system. ..
  5. Craddock N, Jones L, Jones I, Kirov G, Green E, Grozeva D, et al. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry. 2010;15:146-53 pubmed publisher
    ..Our method of phenotype refinement may be useful in studies of other complex psychiatric and non-psychiatric disorders. ..
  6. Ren H, Guan L, Zhao L, Lin Y, Wang Y, Yang Z, et al. Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population. Am J Med Genet B Neuropsychiatr Genet. 2017;: pubmed publisher
    ..For three SNPs, rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, their allele frequencies were significantly different between patients and controls (..
  7. Mehta A, Ticku M. An update on GABAA receptors. Brain Res Brain Res Rev. 1999;29:196-217 pubmed
    ..Furthermore, the molecular determinants of clinically important drug-targets have been investigated. These aspects of GABAA receptors have been discussed in detail in this review article. ..
  8. Neelands T, Macdonald R. Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors. Mol Pharmacol. 1999;56:598-610 pubmed
  9. Sadeghi H, Taylor H. HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation. Am J Physiol Endocrinol Metab. 2010;298:E889-93 pubmed publisher

More Information

Publications16

  1. Zeng Z, Shaffer J, Wang X, Feingold E, Weeks D, Lee M, et al. Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition. J Dent Res. 2013;92:432-7 pubmed publisher
    ..g., CXCR1 and CXCR2, p value = 1.9E-6). This study supports the notion that genes differentially affect cariogenesis across the surfaces of the permanent dentition, and nominates several novel genes for investigation. ..
  2. Kim H, Jin E, Mo J, Shim H, Lee S, Chae S. The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus. J Immunol Res. 2015;2015:602154 pubmed publisher
    Gamma-aminobutyric acid receptor subunit pi (GABRP) is involved in inhibitory synaptic transmission in the central nervous system...
  3. Taylor P, Thomas P, Gorrie G, Connolly C, Smart T, Moss S. Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression. J Neurosci. 1999;19:6360-71 pubmed
    ..Our studies identify, for the first time, key residues within the N-terminal domains of receptor beta subunits that mediate the selective assembly of GABA(A) receptors. ..
  4. Petryshen T, Middleton F, Tahl A, Rockwell G, Purcell S, Aldinger K, et al. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. Mol Psychiatry. 2005;10:1074-88, 1057 pubmed
    ..a group of gamma-aminobutyric acid (GABA) A receptor subunit genes (GABRA1, GABRA6, GABRB2, GABRG2, and GABRP) within our linkage peak...
  5. Zafrakas M, Chorovicer M, Klaman I, Kristiansen G, Wild P, Heindrichs U, et al. Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue. Int J Cancer. 2006;118:1453-9 pubmed
    The GABRP gene has been previously identified by in silico analysis of four million ESTs as a candidate gene differentially expressed in breast cancer...
  6. Sizemore G, Sizemore S, Seachrist D, Keri R. GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2). J Biol Chem. 2014;289:24102-13 pubmed publisher
    ..Expression of the pi subunit of the GABA(A) receptor (GABRP) is associated with the BLBC/TN subtype, and herein, we reveal its expression also correlates with metastases to ..
  7. Sung H, Yang S, Ju W, Ahn J. Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer. Exp Mol Med. 2017;49:e335 pubmed publisher
    ..Using gene expression profiling, we found that γ-aminobutyric acid (GABA)A receptor π subunit (GABRP) expression was upregulated (>4-fold) in metastatic tissues from our xenograft mice compared with SK-OV-3 cells...