GABRA2

Summary

Gene Symbol: GABRA2
Description: gamma-aminobutyric acid type A receptor alpha2 subunit
Alias: gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2
Species: human
Products:     GABRA2

Top Publications

  1. Dick D, Latendresse S, Lansford J, Budde J, Goate A, Dodge K, et al. Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Arch Gen Psychiatry. 2009;66:649-57 pubmed publisher
    ..We describe analyses aimed at characterizing the pathway of risk associated with GABRA2, a gene previously associated with adult alcohol dependence, in a community sample of children followed ..
  2. Philibert R, Gunter T, Beach S, Brody G, Hollenbeck N, Andersen A, et al. Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies. Psychiatr Genet. 2009;19:91-8 pubmed publisher
    A number of studies have shown that genetic variation at GABRA2 alters vulnerability to alcohol dependence...
  3. Fehr C, Sander T, Tadic A, Lenzen K, Anghelescu I, Klawe C, et al. Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet. 2006;16:9-17 pubmed
    ..dependence with the gene encoding the alpha2 subunit of the gamma-aminobutyric acid type A (GABAA) receptor (GABRA2)...
  4. Dick D, Bierut L, Hinrichs A, Fox L, Bucholz K, Kramer J, et al. The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet. 2006;36:577-90 pubmed
    ..dependence and related disorders to develop and test hypotheses about the risk associated with a specific gene, GABRA2, across different developmental stages...
  5. Dick D, Agrawal A, Schuckit M, Bierut L, Hinrichs A, Fox L, et al. Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. J Stud Alcohol. 2006;67:185-94 pubmed
    The gene GABRA2 has been associated with the risk for alcohol dependence in independent samples...
  6. Agrawal A, Edenberg H, Foroud T, Bierut L, Dunne G, Hinrichs A, et al. Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet. 2006;36:640-50 pubmed
    ..Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene...
  7. Soyka M, Preuss U, Hesselbrock V, Zill P, Koller G, Bondy B. GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. J Psychiatr Res. 2008;42:184-91 pubmed
    ..Recent studies have suggested that genetic variants of the GABA-A receptor alpha2 subunit gene (GABRA2) are associated with alcohol dependence...
  8. Villafuerte S, Heitzeg M, Foley S, Yau W, Majczenko K, Zubieta J, et al. Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Mol Psychiatry. 2012;17:511-9 pubmed publisher
    ..alcoholics from non-alcoholics is with variants in the inhibitory ?-amino butyric acid ?2 receptor subunit (GABRA2) gene...
  9. Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, et al. Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcohol Clin Exp Res. 2005;29:493-8 pubmed
    ..have reported association between genetic variation in gamma-amino butyric acid alpha2 receptor subtype (GABRA2) and risk for alcohol dependence...

More Information

Publications128 found, 100 shown here

  1. Bauer L, Covault J, Harel O, Das S, Gelernter J, Anton R, et al. Variation in GABRA2 predicts drinking behavior in project MATCH subjects. Alcohol Clin Exp Res. 2007;31:1780-7 pubmed
    ..studies demonstrated, and replicated, an association between single nucleotide polymorphisms (SNPs) within the GABRA2 gene and risk for alcohol dependence...
  2. Lind P, Macgregor S, Agrawal A, Montgomery G, Heath A, Martin N, et al. The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. Alcohol Clin Exp Res. 2008;32:1721-31 pubmed publisher
    ..have shown that genetic variation in the alpha-2 subunit of the gamma-aminobutyric acid type A (GABA(A)) receptor (GABRA2) is associated with risk for alcohol dependence...
  3. Craddock N, Jones L, Jones I, Kirov G, Green E, Grozeva D, et al. Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype. Mol Psychiatry. 2010;15:146-53 pubmed publisher
    ..Our method of phenotype refinement may be useful in studies of other complex psychiatric and non-psychiatric disorders. ..
  4. ENOCH M, Hodgkinson C, Yuan Q, Shen P, Goldman D, Roy A. The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. Biol Psychiatry. 2010;67:20-7 pubmed publisher
    The GABRA2 gene has been implicated in addiction. Early life stress has been shown to alter GABRA2 expression in adult rodents...
  5. Beneyto M, Abbott A, Hashimoto T, Lewis D. Lamina-specific alterations in cortical GABA(A) receptor subunit expression in schizophrenia. Cereb Cortex. 2011;21:999-1011 pubmed publisher
  6. Villafuerte S, Strumba V, Stoltenberg S, Zucker R, Burmeister M. Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems. Genes Brain Behav. 2013;12:525-31 pubmed publisher
    Genetic variants in GABRA2 have previously been shown to be associated with alcohol measures, electroencephalography (EEG) ? waves and impulsiveness-related traits...
  7. Edenberg H, Dick D, Xuei X, Tian H, Almasy L, Bauer L, et al. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet. 2004;74:705-14 pubmed
    ..analyses of 69 single-nucleotide polymorphism (SNPs) within a cluster of four GABA(A) receptor genes, GABRG1, GABRA2, GABRA4, and GABRB1, at the center of the linked region...
  8. Pierucci Lagha A, Covault J, Feinn R, Nellissery M, Hernandez Avila C, Oncken C, et al. GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology. 2005;30:1193-203 pubmed
    ..on a haplotypic association of alcohol dependence with the gene encoding the GABA(A) receptor alpha-2 subunit (GABRA2), we examined whether GABRA2 alleles are associated with the subjective response to alcohol...
  9. Plawecki M, Wetherill L, Vitvitskiy V, Kosobud A, Zimmermann U, Edenberg H, et al. Voluntary intravenous self-administration of alcohol detects an interaction between GABAergic manipulation and GABRG1 polymorphism genotype: a pilot study. Alcohol Clin Exp Res. 2013;37 Suppl 1:E152-60 pubmed publisher
    ..such variability and conducted a pilot study to assess its utility for detecting an interaction of subjects' GABRA2 or GABRG1 genotype and pretreatment with 1 mg of lorazepam (LZ) vs...
  10. Gundavarapu S, Mishra N, Singh S, Langley R, Saeed A, Feghali Bostwick C, et al. HIV gp120 induces mucus formation in human bronchial epithelial cells through CXCR4/α7-nicotinic acetylcholine receptors. PLoS ONE. 2013;8:e77160 pubmed publisher
    ..Thus, even after ART, lungs from HIV-infected patients contain significant amounts of gp120 and mucus that may contribute to the higher incidence of obstructive pulmonary diseases in this population. ..
  11. Chang L, Jamain S, Lin C, Rujescu D, Tseng G, Sibille E. A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies. PLoS ONE. 2014;9:e90980 pubmed publisher
    ..in neuronal signaling and structure, including glutamate metabotropic receptors (GRM1, GRM7), GABA receptors (GABRA2, GABRA4), and neurotrophic and development-related proteins [BDNF, reelin (RELN), Ephrin receptors (EPHA3, EPHA5)]...
  12. Latendresse S, Henry D, Aggen S, Byck G, Ashbeck A, Bolland J, et al. Dimensionality and Genetic Correlates of Problem Behavior in Low-Income African American Adolescents. J Clin Child Adolesc Psychol. 2017;46:824-839 pubmed publisher
    ..explored the extent to which 3 genes previously implicated for their role in similar behavioral dimensions (CHRM2, GABRA2, and OPRM1) independently accounted for variance within factors specified in the best-fitting model...
  13. Smelson D, Yu L, Buyske S, Gonzalez G, Tischfield J, Deutsch C, et al. Genetic association of GABA-A receptor alpha-2 and mu opioid receptor with cocaine cue-reactivity: evidence for inhibitory synaptic neurotransmission involvement in cocaine dependence. Am J Addict. 2012;21:411-5 pubmed publisher
    ..in 13 candidate genes examined for association with cocaine cue-reactivity, two were statistically significant: GABRA2 (coding for GABA-A receptor alpha-2 subunit; rs11503014, nominal p= ...
  14. Zhou W, He Y, Rehman A, Kong Y, Hong S, Ding G, et al. Loss of function of NCOR1 and NCOR2 impairs memory through a novel GABAergic hypothalamus-CA3 projection. Nat Neurosci. 2019;22:205-217 pubmed publisher
    ..neurons (NS-V mice) recapitulated the memory deficits and had reduced GABAA receptor subunit α2 (GABRA2) expression in lateral hypothalamus GABAergic (LHGABA) neurons...
  15. Gaio V, Nunes B, Fernandes A, Mendonça F, Horta Correia F, Beleza Á, et al. Genetic variation at the CYP2C19 gene associated with metabolic syndrome susceptibility in a South Portuguese population: results from the pilot study of the European Health Examination Survey in Portugal. Diabetol Metab Syndr. 2014;6:23 pubmed publisher
    ..An additive genetic effect of GABRA2 rs279871, NPY rs16147 and TPMT rs1142345 in the MetS score variation was also found...
  16. Fatemi S, Folsom T, Rooney R, Thuras P. Expression of GABAA ?2-, ?1- and ?-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. Transl Psychiatry. 2013;3:e303 pubmed publisher
    ..New avenues for treatment, such as the use of neurosteroids to promote GABA modulation, could potentially ameliorate GABAergic dysfunction in these disorders. ..
  17. Mitchell S, Maguire E, Cunningham L, Gunn B, Linke M, Zechner U, et al. Early-life adversity selectively impairs α2-GABAA receptor expression in the mouse nucleus accumbens and influences the behavioral effects of cocaine. Neuropharmacology. 2018;141:98-112 pubmed publisher
    Haplotypes of the Gabra2 gene encoding the α2-subunit of the GABAA receptor (GABAAR) are associated with drug abuse, suggesting that α2-GABAARs may play an important role in the circuitry underlying drug ..
  18. Trucco E, Villafuerte S, Heitzeg M, Burmeister M, Zucker R. Susceptibility effects of GABA receptor subunit alpha-2 (GABRA2) variants and parental monitoring on externalizing behavior trajectories: Risk and protection conveyed by the minor allele. Dev Psychopathol. 2016;28:15-26 pubmed publisher
    ..Genetic variants of GABA receptor subunit alpha-2 (GABRA2) may increase susceptibility to parental monitoring, thus impacting externalizing trajectories...
  19. Zintzaras E. Gamma-aminobutyric acid A receptor, ?-2 (GABRA2) variants as individual markers for alcoholism: a meta-analysis. Psychiatr Genet. 2012;22:189-96 pubmed publisher
    ..evidence from the genetic association studies (GAS) published to date on the association between variants in the GABRA2 gene and alcoholism has produced inconclusive results...
  20. Nair B, Johar K, Priya A, Wong Riley M. Specificity protein 4 (Sp4) transcriptionally regulates inhibitory GABAergic receptors in neurons. Biochim Biophys Acta. 2016;1863:1-9 pubmed publisher
    ..assays, and western blots, we found that Sp4 functionally regulates the transcription of Gabra1 (GABAA α1) and Gabra2 (GABAA α2), but not Gabra3 (GABAA α3) subunit genes...
  21. Pawar H, Balivada S, Kenney M. Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?. Neurosci Lett. 2018;687:223-233 pubmed publisher
    ..controls, heat stress increased the gene expression of RVLM inhibitory receptor subunits in aged (Gabra1, Gabra2, Gabra5, Glra1) and young (Gabra1) F344 rats at mRNA level, with little change in the expression of RVLM ..
  22. Loddenkemper T, Talos D, Cleary R, Joseph A, Sánchez Fernández I, Alexopoulos A, et al. Subunit composition of glutamate and gamma-aminobutyric acid receptors in status epilepticus. Epilepsy Res. 2014;108:605-15 pubmed publisher
    ..05) and α2/α1 (303%±86; p<0.01). Quantification of mRNA demonstrated an elevated GABRA2/GABRA1 ratio in refractory epilepsy (712; p<0.05) as compared to controls...
  23. Iyer Eimerbrink P, Nurnberger J. Genetics of alcoholism. Curr Psychiatry Rep. 2014;16:518 pubmed publisher
    ..More recent studies in family-based samples have implicated GABRA2, nicotinic receptor genes such as CHRNB3, and a number of other specific single genes as associated with alcohol ..
  24. Iwata H, Yamamuro Y. Subregional Expression of Hippocampal Glutamatergic and GABAergic Genes in F344 Rats with Social Isolation after Weaning. Comp Med. 2016;66:4-9 pubmed
    ..In contrast, pwSI tended to decrease the expression of GABAA receptor subunit genes, and Gabra1, Gabra2, Gabra4, Gabra5, Gabrb2, Gabrg1, and Gabrg2 were all significantly decreased in expression compared with the ..
  25. Ren H, Guan L, Zhao L, Lin Y, Wang Y, Yang Z, et al. Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population. Am J Med Genet B Neuropsychiatr Genet. 2017;: pubmed publisher
    ..For three SNPs, rs505474, rs1398175, and rs4868029 in the GABRA2, GABRA4, and GABRP genes, respectively, their allele frequencies were significantly different between patients and ..
  26. Edenberg H, Foroud T. Genetics of alcoholism. Handb Clin Neurol. 2014;125:561-71 pubmed publisher
    ..2-0.4. A number of other genes important in AUD have been identified and replicated, including GABRA2 and alcohol dehydrogenases 1B and 4. GWAS have identified additional candidates...
  27. te Beek E, Chen X, Jacobs G, Nahon K, de Kam M, Lappalainen J, et al. The effects of the nonselective benzodiazepine lorazepam and the ?2 /?3 subunit-selective GABAA receptor modulators AZD7325 and AZD6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015;4:149-54 pubmed publisher
    ..6% and 10.5%, respectively) did not reach statistical significance, suggesting that doses of AZD7325 or intrinsic efficacy at the ?2 and ?3 receptor subtypes may have been too low. ..
  28. Trucco E, Hicks B, Villafuerte S, Nigg J, Burmeister M, Zucker R. Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use. J Abnorm Psychol. 2016;125:565-75 pubmed publisher
    ..serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, ..
  29. Arias A, Covault J, Feinn R, Pond T, Yang B, Ge W, et al. A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. Alcohol Alcohol. 2014;49:1-9 pubmed publisher
    ..to replicate and extend previous findings of a moderating effect of single nucleotide polymorphisms (SNPs) in GABRA2 (which encodes the GABAA α-2 subunit) on the subjective effects of alcohol by examining SNPs in this and the ..
  30. Sun Y, Zhang Y, Zhang D, Chang S, Jing R, Yue W, et al. GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers. Transl Psychiatry. 2018;8:138 pubmed publisher
    ..The disruptions synchronously were shown on the reward driving system and reward control system. GABRA2 rs279858-linked variants might be a key genetic modulator for heroin vulnerability by affecting the connections of ..
  31. Schlomer G, Cleveland H, Deutsch A, Vandenbergh D, Feinberg M, Greenberg M, et al. Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use. J Youth Adolesc. 2019;48:71-85 pubmed publisher
    ..TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency...
  32. Ji P, Schachtschneider K, Schook L, Walker F, Johnson R. Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets. Brain Behav Immun. 2016;54:243-251 pubmed publisher
    ..g., IL1R1, TLR2, and TLR4), whereas 15 genes associated with the synaptosome and synaptic receptors (e.g., NPTX2, GABRA2, and SLC5A7) were down-regulated...
  33. Panzanelli P, Früh S, Fritschy J. Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus. Brain Struct Funct. 2017;222:4149-4161 pubmed publisher
    ..In contrast, targeted deletion of Gabra2 disrupts perisomatic clustering of gephyrin, but not of ?1-GABAAR, NL2, or dystrophin/dystroglycan...
  34. Kramer J, Chan G, Dick D, Kuperman S, Bucholz K, Edenberg H, et al. Multiple-domain predictors of problematic alcohol use in young adulthood. J Stud Alcohol Drugs. 2008;69:649-59 pubmed
    ..These results demonstrated that GABRA2--originally associated with a diagnosis of alcohol dependence in adults--also predicted the onset of symptoms ..
  35. Saiepour L, Fuchs C, Patrizi A, Sassoè Pognetto M, Harvey R, Harvey K. Complex role of collybistin and gephyrin in GABAA receptor clustering. J Biol Chem. 2010;285:29623-31 pubmed publisher
  36. Russell M, Schlomer G, Cleveland H, Feinberg M, Greenberg M, Spoth R, et al. PROSPER Intervention Effects on Adolescents' Alcohol Misuse Vary by GABRA2 Genotype and Age. Prev Sci. 2018;19:27-37 pubmed publisher
    ..effect modeling (TVEM), to test an age-varying interaction between a single nucleotide polymorphism in the GABRA2 gene (rs279845) and a preventive intervention in predicting alcohol misuse in a longitudinal study of adolescents (..
  37. Mo J, Kim C, Lee D, Sun W, Lee H, Kim H. Early growth response 1 (Egr-1) directly regulates GABAA receptor α2, α4, and θ subunits in the hippocampus. J Neurochem. 2015;133:489-500 pubmed publisher
    ..approach, in combination with in vivo chromatin immunoprecipitation, and reveals that GABAA receptor subunit, GABRA2 (α2), GABRA4 (α4), and GABRQ (θ) genes, are transcriptional targets of Egr-1...
  38. Kiive E, Laas K, Vaht M, Veidebaum T, Harro J. Stressful life events increase aggression and alcohol use in young carriers of the GABRA2 rs279826/rs279858 A-allele. Eur Neuropsychopharmacol. 2017;27:816-827 pubmed publisher
    Research of GABRA2 gene in alcohol use and impulse control suggests its role in aggressive behaviour...
  39. Yang B, Arias A, Feinn R, Krystal J, Gelernter J, Petrakis I. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcohol Clin Exp Res. 2017;: pubmed publisher
    ..In this study, we investigated the effects of 2 AUD-risk-associated single nucleotide polymorphisms, GABRA2 rs279858 and GRIK1 rs2832407, on the subjective response to alcohol administered intravenously to healthy social ..
  40. Kranzler H, Edenberg H. Pharmacogenetics of alcohol and alcohol dependence treatment. Curr Pharm Des. 2010;16:2141-8 pubmed
    ..receptor protein in each: OPRM1 (the &#micro;-opioid receptor gene), DRD4 (the D(4) dopamine receptor gene), GABRA2 (GABA(A) receptor alpha-2 subunit gene), and GRIK1 (the kainite receptor GluR5 subunit gene)...
  41. Drgon T, D Addario C, Uhl G. Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:854-60 pubmed
    ..results delineate the haplotypes and patterns of linkage disequilibrium in this region, focus attention of the GABRA2 gene and identify modest associations between GABRA2 genotypes and addiction phenotypes...
  42. ENOCH M, Zhou Z, Kimura M, Mash D, Yuan Q, Goldman D. GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. PLoS ONE. 2012;7:e29369 pubmed publisher
    ..There were also expression changes specific to cocaine addicts (GAD1, GAD2), alcoholics (GABRA2) and P rats (ABAT, GABRG3)...
  43. ENOCH M. Genetic influences on the development of alcoholism. Curr Psychiatry Rep. 2013;15:412 pubmed publisher
    ..The strongest findings are with genes encoding alcohol metabolizing enzymes. A few candidate genes such as GABRA2 have shown robust associations with alcoholism...
  44. Malhotra S, Basu D, Khullar M, Ghosh A, Chugh N. Candidate genes for alcohol dependence: A genetic association study from India. Indian J Med Res. 2016;144:689-696 pubmed publisher
    ..Likewise, for GABRA2, the frequency of homozygous recessive genotype (G/G) was significantly higher in the control group...
  45. Raud S, Reimets R, Loomets M, Sütt S, Altpere A, Visnapuu T, et al. Deletion of the Wolfram syndrome-related gene Wfs1 results in increased sensitivity to ethanol in female mice. Neuropharmacology. 2015;95:59-67 pubmed publisher
    ..The expression of Gabra2 subunit at 30 minutes after ethanol injection was significantly increased in the frontal cortex of Wfs1-deficient ..
  46. Strac D, Erjavec G, Perkovic M, Sviglin K, Borovecki F, Pivac N. Association of GABAA receptor α2 subunit gene (GABRA2) with alcohol dependence-related aggressive behavior. Prog Neuropsychopharmacol Biol Psychiatry. 2015;63:119-25 pubmed publisher
    ..Recent studies have demonstrated that polymorphisms of the gene encoding the GABAA receptor α2 subunit (GABRA2) are associated with alcohol dependence in different populations of European ancestry...
  47. Manzardo A, McGuire A, Butler M. Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. Gene. 2015;560:184-94 pubmed publisher
    ..g., DRD2, MAOA, and COMT), serotoninergic (e.g., HTR3A, HTR1B, HTR3B, and SLC6A4), GABAergic (e.g., GABRA1, GABRA2, and GABRG1), glutaminergic (GAD1, GRIK3, and GRIN2C) and opioid (e.g...
  48. Orenstein N, Goldberg Stern H, Straussberg R, Bazak L, Weisz Hubshman M, Kropach N, et al. A de novo GABRA2 missense mutation in severe early-onset epileptic encephalopathy with a choreiform movement disorder. Eur J Paediatr Neurol. 2018;22:516-524 pubmed publisher
    ..A de novo heterozygous missense mutation, c.1003A > C, p.Asn335His, was identified in a conserved domain of GABRA2. GABRA2 encodes the ?2 subunit of the GABAA receptor...
  49. Hines R, Maric H, Hines D, Modgil A, Panzanelli P, Nakamura Y, et al. Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin. Nat Commun. 2018;9:3130 pubmed publisher
    ..selectivity, we generate mice with a mutation in the α2-subunit-collybistin binding region (Gabra2-1)...
  50. Das S, Harel O, Dey D, Covault J, Kranzler H. Analysis of extreme drinking in patients with alcohol dependence using Pareto regression. Stat Med. 2010;29:1250-8 pubmed publisher
    ..First, we tested whether a single nucleotide polymorphism within GABRA2 gene, which encodes a subunit of the GABA(A) receptor, and that has been associated with AD, influences 'extreme' ..
  51. Floreani A, Caroli D, Lazzari R, Memmo A, Vidali E, Colavito D, et al. Intrahepatic cholestasis of pregnancy: new insights into its pathogenesis. J Matern Fetal Neonatal Med. 2013;26:1410-5 pubmed publisher
    ..these, three belong to genetic classes involved in pathogenic mechanisms of ICP: (1) pathophysiology of pruritus (GABRA2, cases versus controls = 2, upregulated gene); (2) lipid metabolism and bile composition (HLPT, cases versus ..
  52. Chou K. Modelling extracellular domains of GABA-A receptors: subtypes 1, 2, 3, and 5. Biochem Biophys Res Commun. 2004;316:636-42 pubmed
    ..The present models might be also useful in understanding the basic mechanism of operation of the GABA-A receptors, stimulating novel strategies for developing more specific drugs and better treatments. ..
  53. Agrawal A, Pergadia M, Saccone S, Lynskey M, Wang J, Martin N, et al. An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. Arch Gen Psychiatry. 2008;65:713-21 pubmed publisher
    ..2 was noted on chromosome 4 in the region of the gamma-aminobutyric acid type A gene cluster, including GABRA2, which has been implicated in drug use disorders...
  54. ENOCH M, Hodgkinson C, Yuan Q, Albaugh B, Virkkunen M, Goldman D. GABRG1 and GABRA2 as independent predictors for alcoholism in two populations. Neuropsychopharmacology. 2009;34:1245-54 pubmed publisher
    ..Variation in one chromosome 4 gene, GABRA2, has been robustly associated with alcohol use disorders (AUD) although no functional locus has been identified...
  55. Bauer L, Dick D, Bierut L, Bucholz K, Edenberg H, Kuperman S, et al. Obesity, smoking, and frontal brain dysfunction. Am J Addict. 2010;19:391-400 pubmed publisher
    ..An exploratory ANOVA, substituting the genotype of a GABRA2 SNP for conduct problems, also demonstrated an interaction with obesity affecting P300a latency...
  56. Li D, Sulovari A, Cheng C, Zhao H, Kranzler H, Gelernter J. Association of gamma-aminobutyric acid A receptor ?2 gene (GABRA2) with alcohol use disorder. Neuropsychopharmacology. 2014;39:907-18 pubmed publisher
    ..a meta-analysis of variants in the GABAA receptor genes (GABRB2, GABRA6, GABRA1, and GABRG2 on chromosome 5q and GABRA2 on chromosome 4p12) using genotype data from 4739 cases of alcohol, opioid, or methamphetamine dependence and 4924 ..
  57. Heitzeg M, Villafuerte S, Weiland B, ENOCH M, Burmeister M, Zubieta J, et al. Effect of GABRA2 genotype on development of incentive-motivation circuitry in a sample enriched for alcoholism risk. Neuropsychopharmacology. 2014;39:3077-86 pubmed publisher
    ..Variants in GABRA2 have been associated with adult alcohol dependence as well as phenotypic precursors, including impulsiveness and ..
  58. Hawkins N, Zachwieja N, Miller A, Anderson L, Kearney J. Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq. PLoS Genet. 2016;12:e1006398 pubmed publisher
    ..differences between 129S6/SvEvTac and [129xC57BL/6J]F1 were identified, including the GABAA receptor subunit, Gabra2. Further analysis of Gabra2 demonstrated allele-specific expression...
  59. Mishra B, Wu T, Belfer I, Hodgkinson C, Cohen L, Kiselycznyk C, et al. Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?. Mol Pain. 2007;3:20 pubmed
    ..Similar methods might be applied a larger set of genes in animal models and human laboratory and clinical studies to understand the causes and prevention of pain-related reduction in movement. ..
  60. . Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol. 2014;13:893-903 pubmed publisher
    ..International League Against Epilepsy and multiple governmental and philanthropic agencies. ..
  61. Wang F, Chassin L, Geiser C, Lemery Chalfant K. Mechanisms in the relation between GABRA2 and adolescent externalizing problems. Eur Child Adolesc Psychiatry. 2016;25:67-80 pubmed publisher
    ..The γ-aminobutyric acid A receptor, α2 gene (GABRA2) is associated with a broad spectrum of externalizing problems and disinhibitory-related traits...
  62. Osechkina N, Ivanov M, Nazarov G, Batotsyrenova E, Lapina N, Babkin A, et al. Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol. Bull Exp Biol Med. 2016;160:452-4 pubmed publisher
    ..7 times), Gabra1 (by 3.8 times), and Gabra4 (by 6.5 times), although it diminished expression of Gabra2 gene by 1.4 times...
  63. Ghosh H, Auguadri L, Battaglia S, Simone Thirouin Z, Zemoura K, Messner S, et al. Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission. Nat Commun. 2016;7:13365 pubmed publisher
    ..expression of SUMOylation-deficient gephyrin variants rescued gephyrin clustering in CA1 or neocortical neurons of Gabra2-null mice, which otherwise lack gephyrin clusters, indicating that gephyrin SUMO modification is an essential ..
  64. de Groot C, Floriou Servou A, Tsai Y, Früh S, Kohler M, Parkin G, et al. RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of ?2 GABAA receptors. PLoS Genet. 2017;13:e1007073 pubmed publisher
    ..Finally, using mice lacking Gabra2 subunit, we show that CB1 function is downstream of GABAARs, and we can rescue adult neurogenesis deficit observed ..
  65. Davies P, Hanna M, Hales T, Kirkness E. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature. 1997;385:820-3 pubmed
    ..The expression pattern of this subunit in the brain suggests a new target for manipulation of neuronal pathways within the basal ganglia. ..
  66. Bedford F, Kittler J, Muller E, Thomas P, Uren J, Merlo D, et al. GABA(A) receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1. Nat Neurosci. 2001;4:908-16 pubmed
    ..Our study identifies a previously unknown role for Plic-1, a modulation of GABA(A) receptor cell surface number, which suggests that Plic-1 facilitates accumulation of these receptors in dendritic membranes. ..
  67. Lim C, Kim H, Yu N, Kang S, Kim T, Ko H, et al. Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice. Neuropharmacology. 2017;112:104-112 pubmed publisher
    ..Here, we found that the expression levels of Gabra2, as well as of GABA receptor-mediated inhibitory neurotransmission, are reduced in Shank2 e6-7, but not in e7 KO ..
  68. Newman E, Gunner G, Huynh P, Gachette D, Moss S, Smart T, et al. Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice. Alcohol Clin Exp Res. 2016;40:2445-2455 pubmed publisher
    Alcohol use disorders are associated with single-nucleotide polymorphisms in GABRA2, the gene encoding the GABAA receptor ?2-subunit in humans...
  69. Meyers J, Zhang J, Manz N, Rangaswamy M, Kamarajan C, Wetherill L, et al. A genome wide association study of fast beta EEG in families of European ancestry. Int J Psychophysiol. 2017;115:74-85 pubmed publisher
    ..e., gabra2)...
  70. Bierut L, Agrawal A, Bucholz K, Doheny K, Laurie C, Pugh E, et al. A genome-wide association study of alcohol dependence. Proc Natl Acad Sci U S A. 2010;107:5082-7 pubmed publisher
    ..05. Candidate gene GABRA2, which encodes the GABA receptor alpha2 subunit, was evaluated independently...
  71. Ittiwut C, Yang B, Kranzler H, Anton R, Hirunsatit R, Weiss R, et al. GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans. Alcohol Clin Exp Res. 2012;36:588-93 pubmed publisher
    GABRG1 and GABRA2, genes that encode the ?1 and ?2 subunits, respectively, of the GABA-A receptor, are located in a cluster on chromosome 4p...
  72. Salvatore J, Meyers J, Yan J, Aliev F, Lansford J, Pettit G, et al. Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. J Abnorm Psychol. 2015;124:709-28 pubmed publisher
    ..and whether this indirect effect is further qualified by an interaction between life events and adolescents' GABRA2 genotype (rs279871)...
  73. Navarrete F, García Gutiérrez M, Laborda J, Manzanares J. Deletion of Dlk2 increases the vulnerability to anxiety-like behaviors and impairs the anxiolytic action of alprazolam. Psychoneuroendocrinology. 2017;85:134-141 pubmed publisher
    ..action of alprazolam and the relative gene expression levels of the GABA-A alpha 2 and gamma 2 receptor subunits (Gabra2 and Gabrg2) were also evaluated in the HIPP and AMY of WT and Dlk2-/- mice...
  74. Bonnert T, McKernan R, Farrar S, Le Bourdelles B, Heavens R, Smith D, et al. theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci U S A. 1999;96:9891-6 pubmed
    ..This subunit has a unique distribution, with studies so far suggesting significant expression within monoaminergic neurons of both human and monkey brain. ..
  75. Tian H, Chen H, Cross T, Edenberg H. Alternative splicing and promoter use in the human GABRA2 gene. Brain Res Mol Brain Res. 2005;137:174-83 pubmed
    ..Non-coding variations in GABRA2, the gene encoding the alpha2 subunit, are associated with the risk for alcoholism, suggesting that regulatory ..
  76. Sacco C, Tardif E, Genoud C, Probst A, Tolnay M, Janzer R, et al. GABA receptor subunits in human auditory cortex in normal and stroke cases. Acta Neurobiol Exp (Wars). 2009;69:469-93 pubmed
    ..The GABA(B) receptors had a distinct laminar pattern in auditory areas and minor differences among areas. Unlike in other pathologies, there is no modulation of the GABA(B) receptor expression in subacute or chronic stroke. ..
  77. Kareken D, Liang T, Wetherill L, Dzemidzic M, Bragulat V, Cox C, et al. A polymorphism in GABRA2 is associated with the medial frontal response to alcohol cues in an fMRI study. Alcohol Clin Exp Res. 2010;34:2169-78 pubmed publisher
    ..Significant evidence has accumulated to suggest an association between single-nucleotide polymorphisms (SNPs) in the GABRA2 gene and alcoholism...
  78. Haughey H, Ray L, Finan P, Villanueva R, Niculescu M, Hutchison K. Human gamma-aminobutyric acid A receptor alpha2 gene moderates the acute effects of alcohol and brain mRNA expression. Genes Brain Behav. 2008;7:447-54 pubmed
    ..In fact, recent studies have shown an association between the gene for the alpha2-subunit of the GABA(A) receptor (GABRA2) and alcoholism...
  79. Pham X, Sun C, Chen X, van den Oord E, Neale M, Kendler K, et al. Association study between GABA receptor genes and anxiety spectrum disorders. Depress Anxiety. 2009;26:998-1003 pubmed publisher
    ..We analyzed data from 26 single nucleotide polymorphisms (SNPs) from four GABA receptor genes: GABRA2, GABRA3, GABRA6, and GABRG2...
  80. Onori N, Turchi C, Solito G, Gesuita R, Buscemi L, Tagliabracci A. GABRA2 and alcohol use disorders: no evidence of an association in an Italian case-control study. Alcohol Clin Exp Res. 2010;34:659-68 pubmed publisher
    ..The proposed association between the 3' half of the gene encoding the alpha-2 subunit of GABA receptor (3'-GABRA2) and alcohol use disorders (AUDs) has received several independent confirmations...
  81. Trucco E, Villafuerte S, Burmeister M, Zucker R. Beyond risk: Prospective effects of GABA Receptor Subunit Alpha-2 (GABRA2) × Positive Peer Involvement on adolescent behavior. Dev Psychopathol. 2017;29:711-724 pubmed publisher
    ..This paper examines whether the GABA receptor subunit alpha-2 (GABRA2) single nucleotide polymorphism rs279858 moderates the influence of positive peer affiliation on externalizing ..
  82. Gonzalez Nunez V. Role of gabra2, GABAA receptor alpha-2 subunit, in CNS development. Biochem Biophys Rep. 2015;3:190-201 pubmed publisher
    i>gabra2 gene codes for the alpha-2 subunit of the GABAA receptor, one of the ionotropic receptors which has been related to anxiety, depression and other behavioural disorders, including drug dependence and schizophrenia...
  83. Stickel F, Moreno C, Hampe J, Morgan M. The genetics of alcohol dependence and alcohol-related liver disease. J Hepatol. 2017;66:195-211 pubmed publisher
    ..The way in which this genetic information could potentially inform patient management has yet to be determined and tested. ..
  84. Russek S. Evolution of GABA(A) receptor diversity in the human genome. Gene. 1999;227:213-22 pubmed
  85. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler H. Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet. 2004;129B:104-9 pubmed
    ..showed a haplotypic association of alcohol dependence to the gene encoding the GABAA receptor alpha-2 subunit (GABRA2)...
  86. Ma D, Whitehead P, Menold M, Martin E, Ashley Koch A, Mei H, et al. Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism. Am J Hum Genet. 2005;77:377-88 pubmed
    ..Single-nucleotide polymorphisms (SNPs) were screened in the following genes: GABRG1, GABRA2, GABRA4, and GABRB1 on chromosome 4p12; GABRB2, GABRA6, GABRA1, GABRG2, and GABRP on 5q34-q35...
  87. Fatemi S, Reutiman T, Folsom T, Thuras P. GABA(A) receptor downregulation in brains of subjects with autism. J Autism Dev Disord. 2009;39:223-30 pubmed publisher
    ..We investigated the expression of four GABA(A) receptor subunits and observed significant reductions in GABRA1, GABRA2, GABRA3, and GABRB3 in parietal cortex (Brodmann's Area 40 (BA40)), while GABRA1 and GABRB3 were significantly ..
  88. Agrawal A, Pergadia M, Balasubramanian S, Saccone S, Hinrichs A, Saccone N, et al. Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence. Addiction. 2009;104:471-7 pubmed publisher
    ..association analysis identified polymorphisms in gamma-aminobutyric acid receptor A, subunit 4 (GABRA4) and GABRA2 to be associated with nicotine dependence, as assessed by a score of 4 or more on the Fagerström Test for ..
  89. Trucco E, Villafuerte S, Heitzeg M, Burmeister M, Zucker R. Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse. J Child Psychol Psychiatry. 2014;55:1372-9 pubmed publisher
    This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology...
  90. Boyd S, SCHACHT J, Prisciandaro J, Voronin K, Anton R. Alcohol-Induced Stimulation Mediates the Effect of a GABRA2 SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals. Alcohol Alcohol. 2016;51:549-54 pubmed publisher
    A single-nucleotide polymorphism (SNP) in GABRA2 (rs279858) may moderate subjective response (SR) to alcohol. Results of studies in non-dependent drinkers examining this GABRA2 SNP on SR have been equivocal...
  91. Villafuerte S, Trucco E, Heitzeg M, Burmeister M, Zucker R. Genetic variation in GABRA2 moderates peer influence on externalizing behavior in adolescents. Brain Behav. 2014;4:833-40 pubmed publisher
    ..Several lines of evidence support a role of GABRA2 on externalizing behavior related to disinhibition...