Gab2

Summary

Gene Symbol: Gab2
Description: GRB2 associated binding protein 2
Alias: GRB2-associated-binding protein 2, Grb2-associated binder 2, growth factor receptor bound protein 2-associated protein 2, pp100
Species: human
Products:     Gab2

Top Publications

  1. Lynch D, Daly R. PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J. 2002;21:72-82 pubmed
    Heregulin (HRG)-induced tyrosine phosphorylation of the Gab2 docking protein was enhanced by pretreatment with wortmannin, indicating negative regulation via a PI3-kinase-dependent pathway...
  2. Nishida K, Yoshida Y, Itoh M, Fukada T, Ohtani T, Shirogane T, et al. Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood. 1999;93:1809-16 pubmed
    ..The molecule displays striking homology to Gab1 at the amino acid level; thus, we named it Gab2. It contains a PH domain, proline-rich sequences, and tyrosine residues that bind to SH2 domains when they are ..
  3. Brown L, Kalloger S, Miller M, Shih I, McKinney S, Santos J, et al. Amplification of 11q13 in ovarian carcinoma. Genes Chromosomes Cancer. 2008;47:481-9 pubmed publisher
    ..to the identification of multiple amplicons containing several potential oncogenes including EMSY, PAK1, RSF1, and GAB2. Here, we investigate the amplification of the above four genes and their prognostic significance in histologically ..
  4. Daly R, Gu H, Parmar J, Malaney S, Lyons R, Kairouz R, et al. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer. Oncogene. 2002;21:5175-81 pubmed
    Grb2-associated binder 2 (Gab2) is a recently identified member of the Gab/Daughter of sevenless family of docking proteins, which localize, amplify and integrate signaling pathways activated by various receptors including receptor ..
  5. Sun J, Pedersen M, Ronnstrand L. Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem. 2008;283:27444-51 pubmed publisher
    ..This difference in signaling was shown to be dependent on the association of the scaffolding protein Gab2 with c-Kit, and Src-mediated phosphorylation of Gab2 was shown to be to be independent of the direct association of ..
  6. Herrera Abreu M, Hughes W, Mele K, Lyons R, Rickwood D, Browne B, et al. Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation. Mol Biol Cell. 2011;22:105-16 pubmed publisher
    The docking protein Gab2 is overexpressed in several human malignancies, including breast cancer, and is associated with increased metastatic potential...
  7. Brummer T, Schramek D, Hayes V, Bennett H, Caldon C, Musgrove E, et al. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem. 2006;281:626-37 pubmed
    The docking protein Gab2 is a proto-oncogene product that is overexpressed in primary breast cancers. To determine the functional consequences of Gab2 overexpression, we utilized the immortalized human mammary epithelial cell line MCF-10A...
  8. Nacmias B, Tedde A, Bagnoli S, Cellini E, Guarnieri B, Piacentini S, et al. Implication of GAB2 gene polymorphism in Italian patients with Alzheimer's disease. J Alzheimers Dis. 2009;16:513-5 pubmed publisher
    A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) epsilon4 carriers...
  9. Horst B, Gruvberger Saal S, Hopkins B, Bordone L, Yang Y, Chernoff K, et al. Gab2-mediated signaling promotes melanoma metastasis. Am J Pathol. 2009;174:1524-33 pubmed publisher
    ..in a series of 64 metastatic melanoma samples and 20 melanoma cell lines identified increased copy numbers of Gab2 located on 11q14.1...

More Information

Publications95

  1. Ramirez Lorca R, Boada M, Saez M, Hernandez I, Mauleon A, Rosende Roca M, et al. GAB2 gene does not modify the risk of Alzheimer's disease in Spanish APOE 4 carriers. J Nutr Health Aging. 2009;13:214-9 pubmed
    ..The GAB2 gene has been proposed as a modifying factor of APOE epsilon 4 allele in a recent case-control WGAS conducted in ..
  2. Ikram M, Liu F, Oostra B, Hofman A, van Duijn C, Breteler M. The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis. Biol Psychiatry. 2009;65:995-9 pubmed publisher
    Recently, GAB2 has been suggested to modify the risk of late-onset Alzheimer's disease (AD) among APOEepsilon4 carriers. However, replication data are inconsistent...
  3. Bocanegra M, Bergamaschi A, Kim Y, Miller M, Rajput A, Kao J, et al. Focal amplification and oncogene dependency of GAB2 in breast cancer. Oncogene. 2010;29:774-9 pubmed publisher
    ..One such candidate, the scaffolding adapter protein, GRB2-associated binding protein 2 (GAB2), functions in ErbB signaling and was recently shown to enhance mammary epithelial cell proliferation, and ..
  4. Caron C, Spring K, Laramée M, Chabot C, Cloutier M, Gu H, et al. Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells. Cell Signal. 2009;21:943-53 pubmed publisher
    ..its involvement in endothelial cell survival, as well as the potential contribution of the other family member Gab2 to signalling and biological responses remained unknown...
  5. Yu W, Hawley T, Hawley R, Qu C. Role of the docking protein Gab2 in beta(1)-integrin signaling pathway-mediated hematopoietic cell adhesion and migration. Blood. 2002;99:2351-9 pubmed
    b>Gab2, a newly identified pleckstrin homology domain-containing docking protein, is a major binding protein of SHP-2 tyrosine phosphatase in interleukin (IL)-3-stimulated hematopoietic cells. Its signaling mechanism remains largely unknown...
  6. Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, et al. GAB2 is not associated with late-onset Alzheimer's disease in Japanese. Eur J Hum Genet. 2009;17:682-6 pubmed publisher
    ..Recently, single-nucleotide polymorphisms (SNPs) of the GRB2-associated binding protein 2 gene (GAB2) were shown to be associated with LOAD in Caucasians carrying the APOE-varepsilon4 allele through a genome-wide ..
  7. Schaeper U, Gehring N, Fuchs K, Sachs M, Kempkes B, Birchmeier W. Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol. 2000;149:1419-32 pubmed
    ..Insertion of this site into the Gab1-related protein p97/Gab2 was sufficient to confer c-Met-binding activity...
  8. Chernoff K, Bordone L, Horst B, Simon K, Twadell W, Lee K, et al. GAB2 amplifications refine molecular classification of melanoma. Clin Cancer Res. 2009;15:4288-91 pubmed publisher
    ..b>GAB2 has recently been implicated in melanoma pathogenesis, and increased copy numbers are found in a subset of ..
  9. Fleuren E, O Toole S, Millar E, McNeil C, Lopez Knowles E, Boulghourjian A, et al. Overexpression of the oncogenic signal transducer Gab2 occurs early in breast cancer development. Int J Cancer. 2010;127:1486-92 pubmed publisher
    b>Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear...
  10. Zatkova A, Schoch C, Speleman F, Poppe B, Mannhalter C, Fonatsch C, et al. GAB2 is a novel target of 11q amplification in AML/MDS. Genes Chromosomes Cancer. 2006;45:798-807 pubmed
    ..The newly defined amplicon contains seven genes, including the GRB2-associated binding protein 2 (GAB2)...
  11. Sleegers K, Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn P, et al. Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. Hum Mutat. 2009;30:E338-44 pubmed publisher
    GRB-associated binding protein 2 (GAB2) was recently reported to be a modifier of late-onset Alzheimer dementia (AD) risk in carriers of the APOE epsilon4 allele in a genome-wide association analysis...
  12. Wada T, Nakashima T, Oliveira dos Santos A, Gasser J, Hara H, Schett G, et al. The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med. 2005;11:394-9 pubmed
    ..Here we report that the molecular adapter Grb-2-associated binder-2 (Gab2) associates with RANK and mediates RANK-induced activation of NF-kappaB, Akt and Jnk...
  13. Chapuis J, Hannequin D, Pasquier F, Bentham P, Brice A, Leber I, et al. Association study of the GAB2 gene with the risk of developing Alzheimer's disease. Neurobiol Dis. 2008;30:103-6 pubmed publisher
    The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE varepsilon4-carriers...
  14. Brummer T, Larance M, Herrera Abreu M, Lyons R, Timpson P, Emmerich C, et al. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J. 2008;27:2305-16 pubmed
    ..b>Gab2 signalling is promoted by its association with specific receptors through the adaptor Grb2...
  15. Lin K, Tang M, Han H, Guo Y, Lin Y, Ma C. GAB2 is not associated with late-onset Alzheimer's disease in Chinese Han. Neurol Sci. 2010;31:277-81 pubmed publisher
    It has recently been shown that GAB2 alleles modify the risk for late-onset Alzheimer disease (LOAD) in apolipoprotein E (ApoE)epsilon4 allele carriers in a genome-wide association study...
  16. Schjeide B, Hooli B, Parkinson M, Hogan M, DiVito J, Mullin K, et al. GAB2 as an Alzheimer disease susceptibility gene: follow-up of genomewide association results. Arch Neurol. 2009;66:250-4 pubmed publisher
    Genomewide association (GWA) studies have recently implicated 4 novel Alzheimer disease (AD) susceptibility loci (GAB2, GOLM1, and 2 uncharacterized loci to date on chromosomes 9p and 15q)...
  17. Meng S, Chen Z, Munoz Antonia T, Wu J. Participation of both Gab1 and Gab2 in the activation of the ERK/MAPK pathway by epidermal growth factor. Biochem J. 2005;391:143-51 pubmed
    Three members of Gab family docking proteins, Gab1, Gab2 and Gab3, have been identified in humans...
  18. Zhao C, Yu D, Shen R, Feng G. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J Biol Chem. 1999;274:19649-54 pubmed
    ..We designate this protein as Gab2. Northern blot analysis indicates that Gab2 is widely expressed and has an overlapping but distinctive expression ..
  19. Bennett H, Brummer T, Jeanes A, Yap A, Daly R. Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis. Oncogene. 2008;27:2693-704 pubmed
    The Gab2 docking protein is a target of several oncogenic protein tyrosine kinases and potentiates activation of the Ras/extracellular signal regulated kinase and phosphatidylinositol 3-kinase (PI3-kinase) pathways...
  20. Zhong X, Yu J, Hou G, Xing Y, Jiang H, Li Y, et al. Common variant in GAB2 is associated with late-onset Alzheimer's disease in Han Chinese. Clin Chim Acta. 2011;412:446-9 pubmed publisher
    GRB-associated binding protein 2 (GAB2) may function as a risk factor in the pathogenesis of Alzheimer disease (AD)...
  21. Bentires Alj M, Gil S, Chan R, Wang Z, Wang Y, Imanaka N, et al. A role for the scaffolding adapter GAB2 in breast cancer. Nat Med. 2006;12:114-21 pubmed
    The scaffolding adapter GAB2 maps to a region (11q13-14) commonly amplified in human breast cancer, and is overexpressed in breast cancer cell lines and primary tumors, but its functional role in mammary carcinogenesis has remained ..
  22. Reiman E, Webster J, Myers A, Hardy J, Dunckley T, Zismann V, et al. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. 2007;54:713-20 pubmed
    ..cohorts of 1411 cases and controls, LOAD was associated with six SNPs from the GRB-associated binding protein 2 (GAB2) gene and a common haplotype encompassing the entire GAB2 gene...
  23. Aumann K. [Protein-dysregulation in human and murine myeloproliferative neoplasms]. Pathologe. 2018;39:199-207 pubmed publisher
    ..Protein dysregulation in form of overexpression of GAB2, a protein involved in formation of the CML-pathognomonic BCR/ABL-translocation complex, results in an enhanced ..
  24. Mun S, Ko N, Kim H, Kim J, Kim D, Kim A, et al. Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes. Cell Mol Life Sci. 2010;67:3883-92 pubmed publisher
    ..These included Syk, phospholipase Cγ2, Gab2, MAP kinases, TAK-1, and NF-κB...
  25. Zhou L, Talebian A, Meakin S. The signaling adapter, FRS2, facilitates neuronal branching in primary cortical neurons via both Grb2- and Shp2-dependent mechanisms. J Mol Neurosci. 2015;55:663-77 pubmed publisher
    ..cortical neurons stimulates the tyrosine phosphorylation of FRS2 and the subsequent recruitment of Shp2, Grb2, and Gab2. With FRS2 mutants deficient in Grb2 or Shp2 binding, we demonstrate that FRS2 binds Gab1 and Gab2 through Grb2, ..
  26. Li H, Liang S. Local network topology in human protein interaction data predicts functional association. PLoS ONE. 2009;4:e6410 pubmed publisher
    ..Our study gives clear insight into the common neighbor-based prediction scheme and provides a reliable method for large-scale functional annotation in this post-genomic era. ..
  27. Wang W, Mou K, Wu X, Zhang J, Ren G, Qi J, et al. Grb2-associated binder 2 silencing impairs growth and migration of H1975 cells via modulation of PI3K-Akt signaling. Int J Clin Exp Pathol. 2015;8:10575-84 pubmed
    ..In this study, we tested our hypothesis that Grb2-associated binder 2 (Gab2) regulate NSCLC cancer cell H1975 malignant biological behaviors, and silencing Gab2 reduced H1975 cellular colony ..
  28. Duckworth C, Zhang L, Carroll S, Ethier S, Cheung H. Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression. Oncogene. 2016;35:4036-47 pubmed publisher
    We previously found that the scaffold adapter GRB2-associated binding protein 2 (GAB2) is amplified and overexpressed in a subset of primary high-grade serous ovarian cancers and cell lines...
  29. Guo X, Li T, Xu Y, Xu X, Zhu Z, Zhang Y, et al. Increased levels of Gab1 and Gab2 adaptor proteins skew interleukin-4 (IL-4) signaling toward M2 macrophage-driven pulmonary fibrosis in mice. J Biol Chem. 2017;292:14003-14015 pubmed publisher
    ..Gab1 and Gab2 proteins belong to the Gab family of adaptors and are integral components of the signal specificity in response to ..
  30. Crouin C, Arnaud M, Gesbert F, Camonis J, Bertoglio J. A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners. FEBS Lett. 2001;495:148-53 pubmed
    p97/Gab2 is a recently characterized member of a large family of scaffold proteins that play essential roles in signal transduction...
  31. Tan W, Popel A, Mac Gabhann F. Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation. PLoS ONE. 2013;8:e67438 pubmed publisher
    ..the first computational model of VEGFR2 trafficking and signaling, to study the opposing roles of Gab1 and Gab2 in regulation of Akt phosphorylation in VEGF-stimulated endothelial cells...
  32. Momose H, Kurosu H, Tsujimoto N, Kontani K, Tsujita K, Nishina H, et al. Dual phosphorylation of phosphoinositide 3-kinase adaptor Grb2-associated binder 2 is responsible for superoxide formation synergistically stimulated by Fc gamma and formyl-methionyl-leucyl-phenylalanine receptors in differentiated THP-1 cells. J Immunol. 2003;171:4227-34 pubmed
    ..we identified two Tyr-phosphorylated proteins, c-Cbl (Casitas B-lineage lymphoma) and Grb2-associated binder 2 (Gab2), as PI 3-kinase adaptors that are Tyr phosphorylated upon the stimulation of FcgammaRII in differentiated ..
  33. Harris S, Riggio V, Evenden L, Gilchrist T, McCafferty S, Murphy L, et al. Age-related gene expression changes, and transcriptome wide association study of physical and cognitive aging traits, in the Lothian Birth Cohort 1936. Aging (Albany NY). 2017;9:2489-2503 pubmed publisher
    ..were overexpressed in smokers compared to non-smokers and the expression of transcripts for genes (HERPUD1, GAB2, FAM167A and GLS) previously associated with stress response, autoimmune disease and cancer were ..
  34. Cholay M, Reverdy C, Benarous R, Colland F, Daviet L. Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase. Exp Cell Res. 2010;316:667-75 pubmed publisher
    ..Moreover, we showed that SYK specifically phosphorylates USP25 and alters its cellular levels. This study thus uncovers a new SYK substrate and reveals a novel SYK function, namely the regulation of USP25 cellular levels. ..
  35. Wu C, Lai C, Mobley W. Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci. 2001;21:5406-16 pubmed
    ..NGF induced the formation of a long-lived complex containing C3G/CrkL/Shp2/Gab2/TrkA...
  36. Million R, Harakawa N, Roumiantsev S, Varticovski L, Van Etten R. A direct binding site for Grb2 contributes to transformation and leukemogenesis by the Tel-Abl (ETV6-Abl) tyrosine kinase. Mol Cell Biol. 2004;24:4685-95 pubmed
    ..Deltae5) lacked Grb2 interaction and exhibited decreased binding and phosphorylation of the scaffolding protein Gab2 and impaired activation of phosphatidylinositol 3-kinase, Akt, and extracellular signal-regulated kinase/mitogen-..
  37. Shi L, Sun X, Zhang J, Zhao C, Li H, Liu Z, et al. Gab2 expression in glioma and its implications for tumor invasion. Acta Oncol. 2013;52:1739-50 pubmed publisher
    ..Recently Grb2-associated binder 2 (Gab2), a member of the DOS/Gab family of scaffolding adapters, has been reported to play important roles in the ..
  38. Dorsey J, Cunnick J, Mane S, Wu J. Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl(+) K562 leukemic cells by Gab2. Blood. 2002;99:1388-97 pubmed
    ..In this study, we analyzed the role of the Gab2 docking protein in regulation of the Erk MAP kinase in Bcr-Abl(+) K562 human CML cells...
  39. Xu L, Wang Y, Lan H, Li J, Xia T. Grb2-associated binder-2 gene promotes migration of non-small cell lung cancer cells via Akt signaling pathway. Am J Transl Res. 2016;8:1208-17 pubmed
    ..In the present study, we found that GRB2-associated-binding protein 2 (Gab2) is involved in the migration of NSCLC cells and demonstrated that Gab2 disruption impairs NSCLC cells migration...
  40. Sun L, Zhang B, Liu Y, Shi L, Li H, Lu S. MiR125a-5p acting as a novel Gab2 suppressor inhibits invasion of glioma. Mol Carcinog. 2016;55:40-51 pubmed publisher
    Poor prognosis of glioma is due to the characteristics of high invasiveness. Recently, it was demonstrated that Gab2 was over-expressed and related to cellular migration and invasion in glioma, however, the mechanisms of regulation are ..
  41. Plani Lam J, Slavova Azmanova N, Kucera N, Louw A, Satiaputra J, Singer P, et al. Csk-binding protein controls red blood cell development via regulation of Lyn tyrosine kinase activity. Exp Hematol. 2017;46:70-82.e10 pubmed publisher
    ..The high Akt activity disrupted GAB2/SHP-2 feedback inhibition of Lyn; however, the elevated Lyn activity also increased inhibitory signaling via SHP-1 ..
  42. Jo W, Park H. Antiallergic effect of fisetin on IgE-mediated mast cell activation in vitro and on passive cutaneous anaphylaxis (PCA). J Nutr Biochem. 2017;48:103-111 pubmed publisher
    ..Fisetin decreased the levels of activated spleen tyrosine kinase, Gab2 proteins, linker of activated T cells, extracellular signal-related kinase 1/2 in the IgE/Ag-stimulated RBL2H3 ..
  43. Zhang X, Zhang Y, Tao B, Wang D, Cheng H, Wang K, et al. Docking protein Gab2 regulates mucin expression and goblet cell hyperplasia through TYK2/STAT6 pathway. FASEB J. 2012;26:4603-13 pubmed publisher
    ..Despite numerous studies, the molecular basis for this condition remains elusive. Gab2 is a member of the Dos/Gab subfamily scaffolding molecules and plays important roles in regulating growth, ..
  44. Yang Y, Wu J, Demir A, Castillo Martin M, Melamed R, Zhang G, et al. GAB2 induces tumor angiogenesis in NRAS-driven melanoma. Oncogene. 2013;32:3627-37 pubmed publisher
    b>GAB2 is a scaffold protein with diverse upstream and downstream effectors. MAPK and PI3K signaling pathways are known effectors of GAB2. It is amplified and overexpressed in a variety of human tumors including melanoma...
  45. Hill R, Zozulya S, Lu Y, Ward K, Gishizky M, Jallal B. The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation. Exp Hematol. 2002;30:237-44 pubmed
    ..the C-terminal SH3 domain of Grb2 bound to the nucleotide exchange factor Sos or Grb2-associated binder 2 (Gab2). In contrast, the N-terminal SH3-containing fusion bound to the protein tyrosine phosphatase Lyp...
  46. Bouscary D, Lecoq Lafon C, Chretien S, Zompi S, Fichelson S, Muller O, et al. Role of Gab proteins in phosphatidylinositol 3-kinase activation by thrombopoietin (Tpo). Oncogene. 2001;20:2197-204 pubmed
    In this study, we show that upon thrombopoietin (Tpo) stimulation the two adapter proteins Gab1 and Gab2 are strongly tyrosine phosphorylated and associated with Shc, SHP2, PI 3-kinase and Grb2 in mpl-expressing UT7 cells...
  47. Liu W, Yu W, Zhang J, Chan R, Loh M, Zhang Z, et al. Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations. Leukemia. 2017;31:1415-1422 pubmed publisher
    ..Here we show that the interaction between leukemia-associated mutant Shp2 and Gab2, a scaffolding protein important for cytokine-induced PI3K/Akt signaling, was enhanced, and that the mTOR pathway ..
  48. Aydin Son Y, Batu E, Demirkaya E, Bilginer Y, Kasapcopur O, Unsal E, et al. Systems-level analysis of genome wide association study results for a pilot juvenile idiopathic arthritis family study. Turk J Pediatr. 2015;57:324-33 pubmed
    ..co-expression network also presented the direct interaction of a gene in Fc?Rmediated phagocytosis pathway, namely GAB2, with BLK, CDH13, IL4R and MICA...
  49. Chaussepied M, Ginsberg D. Transcriptional regulation of AKT activation by E2F. Mol Cell. 2004;16:831-7 pubmed
    ..We identify the adaptor protein Grb2 associated binder 2 (Gab2) as a direct E2F target gene and an essential effector of E2F-dependent AKT activation...
  50. Qian P, Zuo Z, Wu Z, Meng X, Li G, Wu Z, et al. Pivotal role of reduced let-7g expression in breast cancer invasion and metastasis. Cancer Res. 2011;71:6463-74 pubmed publisher
    ..rapid metastasis from the orthotopic location, through preferential targets, Grb2-associated binding protein 2 (GAB2) and fibronectin 1 (FN1), and consequent activation of p44/42 mitogen-activated protein kinase (MAPK) and specific ..
  51. Park Y, Bae S, Ji W, Seo E, Lee J, Kim H, et al. GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers. J Korean Med Sci. 2017;32:1784-1791 pubmed publisher
    ..We also found that the proto-oncogene GAB2 (11q14.1) was significantly amplified in non-smokers patients and vice versa in both ArrayCGH and TCGA data...
  52. Liang W, Chen K, Lee W, Sidhar K, Corneveaux J, Allen A, et al. Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOE?4 carriers. Neuroimage. 2011;54:1896-902 pubmed publisher
    ..study (GWAS) of late-onset Alzheimer's disease (AD), we found an association between common haplotypes of the GAB2 gene and AD risk in carriers of the apolipoprotein E (APOE) ?4 allele, the major late-onset AD susceptibility gene...
  53. Park S, Jang S, Shin Y, Yoon B, Lee H, Park H. Grb2-associated binder-1 is required for extrafusal and intrafusal muscle fiber development. Neuroreport. 2017;28:604-609 pubmed publisher
    ..However, Gab2 knockout mice did not show any defects in the development of muscles or muscle spindles...
  54. Koncz G, Bodor C, Kovesdi D, Gáti R, Sarmay G. BCR mediated signal transduction in immature and mature B cells. Immunol Lett. 2002;82:41-9 pubmed
    ..In contrast to mature B cells, crosslinking of BCR on immature B cells did not induce tyrosine phosphorylation of Gab2, thus the Gab2-organized signal amplification complex could not be produced...
  55. Cheng J, Zhong Y, Chen S, Sun Y, Huang L, Kang Y, et al. Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J. 2017;31:5530-5542 pubmed publisher
    Our previous studies have found that Growth factor receptor-bound protein 2-associated binding protein 2 (Gab2)-a docking protein-governs the development of fatty liver disease...
  56. Oh H, Bodelon C, Palakal M, Chatterjee N, Sherman M, Linville L, et al. Ages at menarche- and menopause-related genetic variants in relation to terminal duct lobular unit involution in normal breast tissue. Breast Cancer Res Treat. 2016;158:341-50 pubmed publisher
    ..05), seven SNPs (rs466639: RXRG; rs2243803: SLC14A2; rs2292573: GAB2; rs6438424: 3q13...
  57. Ren S, Xue F, Feng J, Skorski T. Intrinsic regulation of the interactions between the SH3 domain of p85 subunit of phosphatidylinositol-3 kinase and the protein network of BCR/ABL oncogenic tyrosine kinase. Exp Hematol. 2005;33:1222-8 pubmed
    ..The interaction between p85alpha-SH3 and BCR/ABL may be intermediated by proteins such as c-Cbl, Shc, Grb2, and/or Gab2. Mutations in the p85alpha-SH3 region responsible for proline-rich motif binding either abrogate or enhance these ..
  58. Zhan A, Xu X, Chen L, Wang X, Yanfeng X, Dan W, et al. Decreased expression of Gab2 in patients with temporal lobe epilepsy and pilocarpine-induced rat model. Synapse. 2014;68:168-77 pubmed publisher
    Growth factor receptor bound protein-2 associated binding protein-2 (Gab2) is widely expressed in the central nervous system, and participates in multiple signaling pathways...
  59. Yang L, Ma Y, Han W, Li W, Cui L, Zhao X, et al. Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b. J Biol Chem. 2015;290:26627-37 pubmed publisher
    ..Moreover, Grb associated-binding protein 2 (Gab2) was identified as a novel target gene of miR-125b and it mediated PAR2-induced cell migration...
  60. Zou F, Belbin O, Carrasquillo M, Culley O, Hunter T, Ma L, et al. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology. PLoS ONE. 2013;8:e64802 pubmed publisher
    GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer's disease (LOAD) with reported odds ratios (ORs) ranging from 0.75-0.85...
  61. Davis S, Sheppard K, Anglesio M, George J, Traficante N, Fereday S, et al. Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition. Mol Cancer Ther. 2015;14:1495-503 pubmed publisher
    ..Ovarian Tumor Tissue Analysis cohort for 11 copy number amplified genes: ATP13A4, BMP8B, CACNA1C, CCNE1, DYRK1B, GAB2, PAK4, RAD21, TPX2, ZFP36, and URI...
  62. Gu D, Mao J, Pan X, Zhu H, Chen X, Zheng B, et al. microRNA-302c-3p inhibits renal cell carcinoma cell proliferation by targeting Grb2-associated binding 2 (Gab2). Oncotarget. 2017;8:26334-26343 pubmed publisher
    The expression and biological function of Grb2-associated binding 2 (Gab2) in renal cell carcinoma (RCC) cells was tested here. We showed that Gab2 expression was significantly elevated in human RCC tissues and RCC cells...
  63. Hu X, He B, Zhou L, Xie H, Zheng S. Expression Pattern and Clinical Significance of Gab2 Protein in Hepatocellular Carcinoma. Clin Lab. 2016;62:1087-92 pubmed
    To investigate the expression pattern of Gab2 in hepatocellular carcinoma (HCC) and explore the correlation between Gab2 expression and clinicopathological features of HCC patients...
  64. Osinalde N, Sánchez Quiles V, Blagoev B, Kratchmarova I. Changes in Gab2 phosphorylation and interaction partners in response to interleukin (IL)-2 stimulation in T-lymphocytes. Sci Rep. 2016;6:23530 pubmed publisher
    ..Despite lacking intrinsic enzymatic activity, scaffold proteins such as Gab2, play a pivotal role in IL-2-triggered signal transduction integrating, diversifying and amplifying the signal by ..
  65. Liu Y, Jenkins B, Shin J, Rohrschneider L. Scaffolding protein Gab2 mediates differentiation signaling downstream of Fms receptor tyrosine kinase. Mol Cell Biol. 2001;21:3047-56 pubmed
    ..In this report, we identify this 100-kDa protein as the recently cloned scaffolding protein Gab2, and we demonstrate that Gab2 associates with several molecules involved in M-CSF signaling, including Grb2, SHP2, ..
  66. Ding C, Luo J, Li L, Li S, Yang L, Pan H, et al. Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer. J Exp Clin Cancer Res. 2016;35:5 pubmed publisher
    Grb2-associated binder 2 (Gab2), a scaffolding adaptor protein, has recently been implicated in cancer progression. However, the role of Gab2 in the progression and metastasis of colorectal cancer (CRC) remains unclear...
  67. Chen Y, Liu Q, Wu M, Li M, Ding H, Shan X, et al. GAB2 promotes cell proliferation by activating the ERK signaling pathway in hepatocellular carcinoma. Tumour Biol. 2016;37:11763-11773 pubmed
    Grb2-associated binding protein 2 (GAB2), a key member of the family of Gab scaffolding adaptors, is important in the phospoinositide3-kinase (PI3K) and extracellular signal-regulated kinase (ERK) signaling pathways, and is closely ..
  68. Xu X, Wang X, Chen Z, Jin M, Yang W, Zhao G, et al. Overexpression of Grb2-associated binder 2 in human lung cancer. Int J Biol Sci. 2011;7:496-504 pubmed
    Grb2-associated binder 2 (Gab2), a member of the family of Gab scaffolding adaptors, transmits and amplifies the signals from receptor tyrosine kinases...
  69. Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, et al. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. J Biol Chem. 2001;276:45175-83 pubmed
    ..b>Gab2, an adaptor protein of the insulin receptor substrate-1 family, has been shown to be involved in the downstream ..
  70. Izzo G, Forlenza O, Santos B, Bertolucci P, Ojopi E, Gattaz W, et al. Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype. Clinics (Sao Paulo). 2013;68:277-80 pubmed
    In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.
  71. Berry D, Nash P, Liu S, Pawson T, McGlade C. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Curr Biol. 2002;12:1336-41 pubmed
    ..These results provide a molecular explanation for the specific role of Gads in T cell receptor signaling, and identify a discrete subclass of SH3 domains whose binding is dependent on a core R-X-X-K motif. ..
  72. van den Akker E, van Dijk T, Parren van Amelsvoort M, Grossmann K, Schaeper U, Toney Earley K, et al. Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors. Blood. 2004;103:4457-65 pubmed
    ..We studied the roles of the docking molecules Grb2-associated binder-1 (Gab1) and Gab2 in EPO-induced signal transduction and erythropoiesis...
  73. Zhou S, Huriletemuer -, Wang J, Wang B, Zhao S, Wang D, et al. Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients. Neurosci Lett. 2010;480:4-6 pubmed publisher
    GRB-associated binding protein 2 (GAB2) may function as a risk factor of Alzheimer disease (AD) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles...
  74. Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy S, Neel B. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Mol Cell. 2012;47:469-83 pubmed publisher
    ..Our results identify GAB1 as a negative regulator of epithelial cell polarity that functions as a scaffold for modulating PAR protein complexes on the lateral membrane. ..
  75. Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, et al. Engagement of Gab1 and Gab2 in erythropoietin signaling. J Biol Chem. 1999;274:24469-74 pubmed
    ..In the present study we provide evidence that the recently cloned IRS-related proteins, Gab1 and Gab2, of the Gab family of proteins, are rapidly phosphorylated on tyrosine during erythropoietin treatment of ..
  76. Lock L, Royal I, Naujokas M, Park M. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. J Biol Chem. 2000;275:31536-45 pubmed
    ..we have mapped two Grb2 carboxyl-terminal SH3 domain binding sites conserved in Gab1 and related protein Gab2. One corresponds to a canonical Grb2-binding motif, whereas the second, located within the Gab1 Met-binding domain, ..
  77. Toto A, Bonetti D, De Simone A, Gianni S. Understanding the mechanism of binding between Gab2 and the C terminal SH3 domain from Grb2. Oncotarget. 2017;8:82344-82351 pubmed publisher
    b>Gab2 is a large disordered protein that regulates several cellular signalling pathways and is overexpressed in different forms of cancer...
  78. Ding C, Luo J, Fan X, Li L, Li S, Wen K, et al. Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels. J Exp Clin Cancer Res. 2017;36:56 pubmed publisher
    Grb2-associated binder 2 (Gab2) is a scaffolding protein that serves as a critical signaling amplifier downstream of tyrosine kinase receptors...
  79. Wu J, Meng F, Lu H, Kong L, Bornmann W, Peng Z, et al. Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells. Blood. 2008;111:3821-9 pubmed publisher
    ..In imatinib-resistant CML cells and patients, Lyn activation is BCR-ABL independent, it is complexed with the Gab2 and c-Cbl adapter/scaffold proteins, and it mediates persistent Gab2 and BCR-ABL tyrosine phosphorylation in the ..
  80. Deng H, Fung G, Qiu Y, Wang C, Zhang J, Jin Z, et al. Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Coxsackievirus Infection. Front Cell Infect Microbiol. 2017;7:85 pubmed publisher
    ..b>GAB2 is a mammalian homolog of GAB1...
  81. Zhang X, Dong Z, Zhang C, Ung C, He S, Tao T, et al. Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation. Cell Rep. 2017;18:2932-2942 pubmed publisher
    ..We identify a similar mechanism in tumors with wild-type ptpn11 and dysregulated Gab2, which encodes a Shp2 activator that is overexpressed in human neuroblastomas...
  82. Nishida K, Yamasaki S, Hasegawa A, Iwamatsu A, Koseki H, Hirano T. Gab2, via PI-3K, regulates ARF1 in Fc?RI-mediated granule translocation and mast cell degranulation. J Immunol. 2011;187:932-41 pubmed publisher
    ..IgE-dependent activation through Fc?R leads to degranulation and cytokine production, both of which require Gab2. To clarify how the signals diverge at Gab2, we established Gab2 knock-in mice that express Gab2 mutated at either ..
  83. Wang C, Gu C, Jeong K, Zhang D, Guo W, Lu Y, et al. YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway. Cancer Res. 2017;77:1637-1648 pubmed publisher
    ..markedly decreased both constitutive and growth factor-induced PI3K pathway activation by decreasing levels of the GAB2 linker molecule in endometrial cancer lines...
  84. Kauwe J, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, et al. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. J Alzheimers Dis. 2010;21:833-42 pubmed publisher
    Recent large-scale genetic studies of late-onset Alzheimer's disease have identified risk variants in CALHM1, GAB2, and SORL1. The mechanisms by which these genes might modulate risk are not definitively known...
  85. Wang G, Pan X, Cui P, Wang Y, Ma J, Ren R, et al. Association study of the GAB2 gene with the risk of Alzheimer disease in the chinese population. Alzheimer Dis Assoc Disord. 2011;25:283-5 pubmed publisher
    To assess genetic variations of GAB2 as a risk factor for developing Alzheimer disease (AD)...