G72

Summary

Gene Symbol: G72
Description: D-amino acid oxidase activator
Alias: LG72, SG72, D-amino acid oxidase activator, G72 transcript, schizophrenia- and bipolar disorder-associated protein G72
Species: human
Products:     G72

Top Publications

  1. Wood L, Pickering E, Dechairo B. Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia. Biol Psychiatry. 2007;61:1195-9 pubmed
    ..However, we see no evidence to support either DAOA or DTNBP1 as schizophrenia disease loci. ..
  2. Hattori E, Liu C, Badner J, Bonner T, Christian S, Maheshwari M, et al. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Am J Hum Genet. 2003;72:1131-40 pubmed
    ..Recently, genes called "G72" and "G30" were identified, and polymorphisms of these overlapping genes were reported to be ..
  3. Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, et al. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Biol Psychiatry. 2004;56:169-76 pubmed
    The genes G72/G30 were recently implicated in schizophrenia in both Canadian and Russian populations...
  4. Otte D, Bilkei Gorzo A, Filiou M, Turck C, Yilmaz O, Holst M, et al. Behavioral changes in G72/G30 transgenic mice. Eur Neuropsychopharmacol. 2009;19:339-48 pubmed publisher
    ..It encodes for a protein LG72 whose function has been controversially discussed as putative regulator of the peroxisomal enzyme D-amino-acid-..
  5. Andreou D, Saetre P, Werge T, Andreassen O, Agartz I, Sedvall G, et al. D-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians. Eur Arch Psychiatry Clin Neurosci. 2012;262:549-56 pubmed publisher
  6. Zuliani R, Moorhead T, Job D, McKirdy J, Sussmann J, Johnstone E, et al. Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder. Bipolar Disord. 2009;11:621-7 pubmed publisher
    Variation in the G72 (DAOA) gene is understood to convey susceptibility for bipolar disorder through an uncertain mechanism. Little is known about the structural brain phenotypes associated with this gene...
  7. Maheshwari M, Shi J, Badner J, Skol A, Willour V, Muzny D, et al. Common and rare variants of DAOA in bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:960-6 pubmed publisher
    The D-amino acid oxidase activator (DAOA, previously known as G72) gene, mapped on 13q33, has been reported to be genetically associated with bipolar disorder (BP) in several populations...
  8. Hartz S, Ho B, Andreasen N, Librant A, Rudd D, Epping E, et al. G72 influences longitudinal change in frontal lobe volume in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:640-647 pubmed publisher
    ..Schizophrenia also is highly heritable, and one gene that has emerged as a possible susceptibility factor is G72. G72 influences brain development and activity by an as-yet unclear mechanism, and multiple studies have reported ..
  9. Detera Wadleigh S, McMahon F. G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry. 2006;60:106-14 pubmed
    Association of the G72/G30 locus with schizophrenia and bipolar disorder has now been reported in several studies...

More Information

Publications71

  1. Sanders A, Duan J, Levinson D, Shi J, He D, Hou C, et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry. 2008;165:497-506 pubmed publisher
    ..It is unlikely that common SNPs in these genes account for a substantial proportion of the genetic risk for schizophrenia, although small effects cannot be ruled out. ..
  2. Yue W, Kang G, Zhang Y, Qu M, Tang F, Han Y, et al. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects. Neurosci Lett. 2007;416:96-100 pubmed
    ..05). These results support the hypothesis that variations in DAOA may play a role in schizophrenia and clinical characteristics. ..
  3. Gomez L, Wigg K, Feng Y, Kiss E, Kapornai K, Tamás Z, et al. G72/G30 (DAOA) and juvenile-onset mood disorders. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:1007-12 pubmed publisher
    ..Within this region are the overlapping genes G72/G30, with G72 now officially named as D-amino-acid oxidase activator (DAOA)...
  4. Dalvie S, Horn N, Nossek C, van der Merwe L, Stein D, Ramesar R. Psychosis and relapse in bipolar disorder are related to GRM3, DAOA, and GRIN2B genotype. Afr J Psychiatry (Johannesbg). 2010;13:297-301 pubmed
    ..Speculatively, newly derived genes associated with various evolutionary advantages, may also increase the risk for more severe BD. These preliminary findings deserve validation in a larger cohort. ..
  5. Shi J, Badner J, Gershon E, Chunyu L, Willour V, Potash J. Further evidence for an association of G72/G30 with schizophrenia in Chinese. Schizophr Res. 2009;107:324-6 pubmed publisher
  6. Shi J, Badner J, Gershon E, Liu C. Allelic association of G72/G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophr Res. 2008;98:89-97 pubmed
    The G72/G30 gene complex (G72 also known as D-amino acid oxidase activator, DAOA) and its chromosomal region 13q32-34 have been linked and associated with both schizophrenia (SCZ) and bipolar disorder (BP) in multiple studies, including ..
  7. Owen M, Craddock N, O Donovan M. Schizophrenia: genes at last?. Trends Genet. 2005;21:518-25 pubmed
    ..in schizophrenia 1 (DISC1), D-amino-acid oxidase (DAO), D-amino-acid oxidase activator (DAOA, formerly known as G72) and regulator of G-protein signalling 4 (RGS4), the data are promising but not yet compelling...
  8. Boks M, Rietkerk T, van de Beek M, Sommer I, de Koning T, Kahn R. Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia. Eur Neuropsychopharmacol. 2007;17:567-72 pubmed
    We review the role of two susceptibility genes; G72 and DAAO in glutamate neurotransmission and the aetiology of schizophrenia...
  9. Li D, He L. G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies. Genetics. 2007;175:917-22 pubmed
    ..Linkage disequilibrium mapping has identified several promising and novel positional candidates, including the G72/G30 and d-amino-acid oxidase (DAAO) genes...
  10. Liu Y, Fann C, Liu C, Chang C, Wu J, Hung S, et al. No association of G72 and D-amino acid oxidase genes with schizophrenia. Schizophr Res. 2006;87:15-20 pubmed
    The genes of D-amino acid oxidase (DAAO) activator (DAOA or G72; 13q34) and DAAO (12q24) have been suggested as candidate genes and involved in the N-methyl-D-aspartate receptor regulation pathway for schizophrenia...
  11. Pae C, Chiesa A, Serretti A. Influence of DAOA gene variants on antipsychotic response after switch to aripiprazole. Psychiatry Res. 2010;178:430-2 pubmed publisher
    ..Further research is needed to determine the role of DAOA on the response to antipsychotics. ..
  12. Goldberg T, Straub R, Callicott J, Hariri A, Mattay V, Bigelow L, et al. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. Neuropsychopharmacology. 2006;31:2022-32 pubmed
    A recently discovered gene complex, G72/G30 (hereafter G72, but now termed DAOA), was found to be associated with schizophrenia and with bipolar disorder, possibly because of an indirect effect on NMDA neurotransmission...
  13. Maier W. Common risk genes for affective and schizophrenic psychoses. Eur Arch Psychiatry Clin Neurosci. 2008;258 Suppl 2:37-40 pubmed publisher
    ..molecular-genetic discoveries: specific alleles in the genes for dysbindin (DTNBP1), neuregulin (NRG1) and DAOA (G72/G30) reveal associations for each of both groups of disorders in the same direction in some but not all reported ..
  14. Soronen P, Silander K, Antila M, Palo O, Tuulio Henriksson A, Kieseppä T, et al. Association of a nonsynonymous variant of DAOA with visuospatial ability in a bipolar family sample. Biol Psychiatry. 2008;64:438-42 pubmed publisher
    ..The DAOA gene may play a role in predisposing individuals to a mixed phenotype of psychosis and mania and to impairments in related neuropsychological traits. ..
  15. Rietschel M, Beckmann L, Strohmaier J, Georgi A, Karpushova A, Schirmbeck F, et al. G72 and its association with major depression and neuroticism in large population-based groups from Germany. Am J Psychiatry. 2008;165:753-62 pubmed publisher
    b>G72 is among the most frequently replicated vulnerability genes for schizophrenia and bipolar disorder...
  16. Jansen A, Krach S, Krug A, Markov V, Eggermann T, Zerres K, et al. A putative high risk diplotype of the G72 gene is in healthy individuals associated with better performance in working memory functions and altered brain activity in the medial temporal lobe. Neuroimage. 2009;45:1002-8 pubmed publisher
    b>G72 is a vulnerability gene for schizophrenia and affective psychosis, disorders that are characterized by deficits in working memory...
  17. Donohoe G, Morris D, Robertson I, McGhee K, Murphy K, Kenny N, et al. DAOA ARG30LYS and verbal memory function in schizophrenia. Mol Psychiatry. 2007;12:795-6 pubmed
  18. Schultz C, Nenadic I, Koch K, Wagner G, Roebel M, Schachtzabel C, et al. Reduced cortical thickness is associated with the glutamatergic regulatory gene risk variant DAOA Arg30Lys in schizophrenia. Neuropsychopharmacology. 2011;36:1747-53 pubmed publisher
    ..Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia. ..
  19. Prata D, Breen G, Osborne S, Munro J, St Clair D, Collier D. Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:914-7 pubmed publisher
    ..In the present study we investigated whether individual polymorphisms or haplotypes of the DAO and G72(DAOA)/G30 genes, which have been previously implicated in schizophrenia, are also associated with bipolar disorder...
  20. Jansen A, Krach S, Krug A, Markov V, Eggermann T, Zerres K, et al. Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects. BMC Psychiatry. 2009;9:60 pubmed publisher
    In the last years, several susceptibility genes for psychiatric disorders have been identified, among others G72 (also named D-amino acid oxidase activator, DAOA)...
  21. Kvajo M, Dhilla A, Swor D, Karayiorgou M, Gogos J. Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function. Mol Psychiatry. 2008;13:685-96 pubmed
    ..Here we show that one splicing isoform of the gene (LG72) encodes for a mitochondrial protein...
  22. Sacchi S, Bernasconi M, Martineau M, Mothet J, Ruzzene M, Pilone M, et al. pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase: effect on schizophrenia susceptibility. J Biol Chem. 2008;283:22244-56 pubmed publisher
  23. Krug A, Markov V, Krach S, Jansen A, Zerres K, Eggermann T, et al. Genetic variation in G72 correlates with brain activation in the right middle temporal gyrus in a verbal fluency task in healthy individuals. Hum Brain Mapp. 2011;32:118-26 pubmed publisher
    The D-amino acid oxidase activator gene (G72) has been found associated with several psychiatric disorders such as schizophrenia, major depression, and bipolar disorder...
  24. Sacchi S, Cappelletti P, Giovannardi S, Pollegioni L. Evidence for the interaction of D-amino acid oxidase with pLG72 in a glial cell line. Mol Cell Neurosci. 2011;48:20-8 pubmed publisher
    Accumulating genetic evidence indicates that the primate-specific gene locus G72/G30 is related to schizophrenia: it encodes for the protein pLG72, whose function is still the subject of controversy...
  25. Muller D, Zai C, Shinkai T, Strauss J, Kennedy J. Association between the DAOA/G72 gene and bipolar disorder and meta-analyses in bipolar disorder and schizophrenia. Bipolar Disord. 2011;13:198-207 pubmed publisher
    The D-amino acid oxidase activator (DAOA, or G72) is involved in the oxidation of D-serine, an endogenous modulator of N-methyl-D-aspartate receptors and thus represents an important candidate in psychotic disorders...
  26. Vilella E, Costas J, Sanjuan J, Guitart M, de Diego Y, Carracedo A, et al. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. J Psychiatr Res. 2008;42:278-88 pubmed
    ..In the light of recent data, these results need to be interpreted with caution and future analyses with dense genetic maps are awaited. ..
  27. Benzel I, Kew J, Viknaraja R, Kelly F, de Belleroche J, Hirsch S, et al. Investigation of G72 (DAOA) expression in the human brain. BMC Psychiatry. 2008;8:94 pubmed publisher
    Polymorphisms at the G72/G30 locus on chromosome 13q have been associated with schizophrenia or bipolar disorder in more than ten independent studies...
  28. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 2002;99:13675-80 pubmed
    ..Two overlapping genes G72 and G30 transcribed in brain were experimentally annotated in this 65-kb region...
  29. Jonsson E, Saetre P, Vares M, Andreou D, Larsson K, Timm S, et al. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. Neuropsychobiology. 2009;59:142-50 pubmed publisher
    ..dystrobrevin-binding protein 1 gene (DTNBP1), neuregulin 1 (NRG1), D-amino-acid oxidase (DAO), DAO activator (DAOA, G72), and metabotropic glutamate receptor 3 (GRM3) genes have suggested an association between variants of these genes ..
  30. Kotaka T, Ujike H, Okahisa Y, Takaki M, Nakata K, Kodama M, et al. G72 gene is associated with susceptibility to methamphetamine psychosis. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:1046-9 pubmed publisher
    ..Several genes related to glutamate function, e.g. the DTNBP1, G72, and GRM3 genes, were shown to be associated with schizophrenia susceptibility...
  31. Schulze T, Ohlraun S, Czerski P, Schumacher J, Kassem L, Deschner M, et al. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. Am J Psychiatry. 2005;162:2101-8 pubmed
    ..These data suggest that bipolar affective disorder with persecutory delusions constitutes a distinct subgroup of bipolar affective disorder that overlaps with schizophrenia. ..
  32. Schumacher J, Jamra R, Freudenberg J, Becker T, Ohlraun S, Otte A, et al. Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder. Mol Psychiatry. 2004;9:203-7 pubmed
    A recent study has suggested that the brain-expressed genes for G72 and D-amino-acid oxidase (DAAO) exert an influence on susceptibility to schizophrenia...
  33. Nicodemus K, Kolachana B, Vakkalanka R, Straub R, Giegling I, Egan M, et al. Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia. Hum Genet. 2007;120:889-906 pubmed
    ..Evidence for interaction was evaluated using a likelihood ratio test (LRT) between nested models. SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT...
  34. Otte D, Sommersberg B, Kudin A, Guerrero C, Albayram O, Filiou M, et al. N-acetyl cysteine treatment rescues cognitive deficits induced by mitochondrial dysfunction in G72/G30 transgenic mice. Neuropsychopharmacology. 2011;36:2233-43 pubmed publisher
    ..This gene encodes the protein LG72 that has been discussed to function as a putative activator of the peroxisomal enzyme D-amino-acid-oxidase (DAO) ..
  35. Opgen Rhein C, Lencz T, Burdick K, Neuhaus A, DeRosse P, Goldberg T, et al. Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performance. Schizophr Res. 2008;103:169-77 pubmed publisher
  36. Zhang Z, Li Y, Zhao Q, Huang K, Wang P, Yang P, et al. First evidence of association between G72 and bipolar disorder in the Chinese Han population. Psychiatr Genet. 2009;19:151-3 pubmed publisher
    The G72/G30 (D-amino-acid oxidase activator) complex was the first gene to be associated with bipolar disorder (BPD) in European populations, but until now no such association has been identified in Asian populations...
  37. Hall J, Whalley H, Moorhead T, Baig B, McIntosh A, Job D, et al. Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia. Biol Psychiatry. 2008;64:428-33 pubmed publisher
    ..exists for an association between genetic variation in the gene DAOA (D-amino acid oxidase activator, also known as G72) and risk for schizophrenia...
  38. Ohi K, Hashimoto R, Yasuda Y, Yoshida T, Takahashi H, Iike N, et al. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. Schizophr Res. 2009;109:80-5 pubmed publisher
    b>G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA)...
  39. Nixon D, Prust M, Sambataro F, Tan H, Mattay V, Weinberger D, et al. Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex. Biol Psychiatry. 2011;69:1006-8 pubmed publisher
    ..These in vivo results suggest that deleterious genotypes for DAOA and COMT might contribute to the pathophysiology of schizophrenia, perhaps through combined glutamatergic and dopaminergic dysregulation. ..
  40. Mossner R, Schuhmacher A, Wagner M, Quednow B, Frommann I, Kuhn K, et al. DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis. Eur Arch Psychiatry Clin Neurosci. 2010;260:209-15 pubmed publisher
    ..a unique prospective multicentre trial, we assessed whether variants at the D-amino acid oxidase activator (DAOA)/G72 locus influence progression to psychosis...
  41. Williams N, Green E, Macgregor S, Dwyer S, Norton N, Williams H, et al. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Arch Gen Psychiatry. 2006;63:366-73 pubmed
    ..Instead, our results imply that variation at the DAOA/G30 locus influences susceptibility to episodes of mood disorder across the traditional bipolar and schizophrenia categories. ..
  42. Cappelletti P, Campomenosi P, Pollegioni L, Sacchi S. The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain. FEBS J. 2014;281:708-23 pubmed publisher
    ..Overexpression of pLG72 increases the turnover of hDAAO, in turn playing a protective role against excessive D-serine depletion. ..
  43. Chiesa A, Pae C, Porcelli S, Han C, Lee S, Patkar A, et al. DAOA variants on diagnosis and response to treatment in patients with major depressive disorder and bipolar disorder. J Int Med Res. 2012;40:258-65 pubmed
    ..Given the study's limitations, further investigation should be carried out. ..
  44. Mechelli A, Fusar Poli P, Prata D, Papagni S, Tognin S, Kambeitz J, et al. Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72. Curr Pharm Des. 2012;18:510-7 pubmed
    Recent studies have described G72 and DAAO as susceptibility genes for schizophrenia and bipolar disorder...
  45. Chen J, Xu Y, Zhang J, Liu Z, Xu C, Zhang K, et al. Genotypic association of the DAOA gene with resting-state brain activity in major depression. Mol Neurobiol. 2012;46:361-73 pubmed publisher
    ..Genotypic effect of rs2391191 and its interaction with disease status may contribute to the altered ReHo in patients with MDD. Glutamatergic modulation may play an important role in alteration of the resting-state brain activities. ..
  46. Sehgal S, Khattak N, Mir A. Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene. Theor Biol Med Model. 2013;10:3 pubmed publisher
    ..D-amino acid oxidase activator (DAOA), also known as G72, is directly implicated in the glutamateric hypothesis of schizophrenia...
  47. Utge S, Soronen P, Partonen T, Loukola A, Kronholm E, Pirkola S, et al. A population-based association study of candidate genes for depression and sleep disturbance. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:468-476 pubmed publisher
    ..These differences may partially explain the broad spectrum of depressive symptoms, and their systematic monitoring could potentially be used for diagnostic purposes. ..
  48. Di Maria E, Bonvicini C, Bonomini C, Alberici A, Zanetti O, Gennarelli M. Genetic variation in the G720/G30 gene locus (DAOA) influences the occurrence of psychotic symptoms in patients with Alzheimer's disease. J Alzheimers Dis. 2009;18:953-60 pubmed publisher
    ..the hypothesis that the occurrence of delusions and hallucinations in AD is associated with variations in the G72/DAOA gene, which is supposed to play a key role in the glutamate pathway regulated through the NMDA receptors...
  49. Corvin A, McGhee K, Murphy K, Donohoe G, Nangle J, Schwaiger S, et al. Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:949-53 pubmed
    ..be mediated through modulation of NMDA function by DAO, which is in turn activated by DAO activator (DAOA, formerly G72). Chumakov et al...
  50. Gaysina D, Cohen Woods S, Chow P, Martucci L, Schosser A, Ball H, et al. Association analysis of DAOA and DAO in bipolar disorder: results from two independent case-control studies. Bipolar Disord. 2010;12:579-81 pubmed publisher
  51. Cheng L, Hattori E, Nakajima A, Woehrle N, Opal M, Zhang C, et al. Expression of the G72/G30 gene in transgenic mice induces behavioral changes. Mol Psychiatry. 2014;19:175-83 pubmed publisher
    ..The highest G72 transcript levels were found in testis, followed by cerebral cortex, with very low or undetectable levels in other ..
  52. Sacchetti E, Scassellati C, Minelli A, Valsecchi P, Bonvicini C, Pasqualetti P, et al. Schizophrenia susceptibility and NMDA-receptor mediated signalling: an association study involving 32 tagSNPs of DAO, DAOA, PPP3CC, and DTNBP1 genes. BMC Med Genet. 2013;14:33 pubmed publisher
  53. Suliman H, Schumacher J, Becker T, Cichon S, Schulze T, Propping P, et al. Association study of 20 genetic variants at the (D)-amino acid oxidase gene in schizophrenia. Psychiatr Genet. 2010;20:82-3 pubmed publisher
  54. Potash J. Carving chaos: genetics and the classification of mood and psychotic syndromes. Harv Rev Psychiatry. 2006;14:47-63 pubmed
    ..One gene, DAOA (D-amino acid oxidase activator, also known as G72), has been repeatedly implicated as an overlap gene, while DISC1 and others may constitute additional shared ..
  55. Kang G, Yue W, Zhang J, Huebner M, Zhang H, Ruan Y, et al. Two-stage designs to identify the effects of SNP combinations on complex diseases. J Hum Genet. 2008;53:739-46 pubmed publisher
    ..that there may be interactive effects for schizophrenia among variants of the genes neuregulin 1 (NRG1, 8p22-p11), G72 (13q34), the regulator of G-protein signaling-4 (RGS4, 1q21-q22) and frizzled 3 (FZD3, 8p21)...
  56. Chung S, Jung J, Chung H, Yoo H, Kim C, Joo Y, et al. No association between polymorphisms of DAO and DAOA genes and homicidal behaviors in Korean schizophrenia. Psychiatr Genet. 2007;17:313 pubmed
  57. Shinkai T, De Luca V, Hwang R, Muller D, Lanktree M, Zai G, et al. Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Neuromolecular Med. 2007;9:169-77 pubmed
    ..Chumakov and colleagues (2002) identified a gene complex called G72 (now termed D-amino acid oxidase activator: DAOA)/G30 in this region and performed association analyses of the DAOA/..
  58. Bakker S, Hoogendoorn M, Hendriks J, Verzijlbergen K, Caron S, Verduijn W, et al. The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia. Genes Brain Behav. 2007;6:113-9 pubmed
    ..Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both ..
  59. Jagannath V, Brotzakis Z, Parrinello M, Walitza S, Grunblatt E. Controversial Effects of D-Amino Acid Oxidase Activator (DAOA)/G72 on D-Amino Acid Oxidase (DAO) Activity in Human Neuronal, Astrocyte and Kidney Cell Lines: The N-methyl D-aspartate (NMDA) Receptor Hypofunction Point of View. Front Mol Neurosci. 2017;10:342 pubmed publisher
    Dysfunction of D-amino acid oxidase (DAO) and DAO activator (DAOA)/G72 genes have been linked to neuropsychiatric disorders...
  60. Grigoroiu Serbanescu M, Herms S, Diaconu C, Jamra R, Meier S, Bleotu C, et al. Possible association of different G72/G30 SNPs with mood episodes and persecutory delusions in bipolar I Romanian patients. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:657-63 pubmed publisher
    The G72/G30 gene is one of the common loci shared both by schizophrenia and bipolar disorder. Studies accumulating since the discovery of this gene complex produced controversial results in both disorders in different populations...
  61. Bousman C, Yung A, Pantelis C, Ellis J, Chavez R, Nelson B, et al. Effects of NRG1 and DAOA genetic variation on transition to psychosis in individuals at ultra-high risk for psychosis. Transl Psychiatry. 2013;3:e251 pubmed publisher
    ..None of the assessed DAOA htSNPs were associated with transition. Our findings suggest NRG1 genetic variation may improve our ability to identify UHR individuals at risk for transition to psychosis. ..
  62. Kato Y, Fukui K. Structure models of G72, the product of a susceptibility gene to schizophrenia. J Biochem. 2017;161:223-230 pubmed publisher
    The G72 gene is one of the most susceptible genes to schizophrenia and is contained exclusively in the genomes of primates...