G2A

Summary

Gene Symbol: G2A
Description: G protein-coupled receptor 132
Alias: G2A, G2 accumulation protein
Species: human
Products:     G2A

Top Publications

  1. Has Simsek D, Kuyumcu S, Turkmen C, Sanlı Y, Aykan F, Unal S, et al. Can complementary 68Ga-DOTATATE and 18F-FDG PET/CT establish the missing link between histopathology and therapeutic approach in gastroenteropancreatic neuroendocrine tumors?. J Nucl Med. 2014;55:1811-7 pubmed publisher
    ..Grade 2 (G2) patients were further evaluated in 2 groups as G2a (3%-9%) and G2b (10%-20%) according to Ki67 indices...
  2. Wen Z, Li J, Zhang Y, Zhou Q, Gong L, Xue C, et al. Genetic epidemiology of porcine epidemic diarrhoea virus circulating in China in 2012-2017 based on spike gene. Transbound Emerg Dis. 2018;65:883-889 pubmed publisher
    ..In all strains, G1a, G1b, G2a and G2b clusters accounted for 1.9%, 9.6%, 32.2% and 56...
  3. Kwon H, Jeong N, Jun S, Son J, Kim S, Jeon H, et al. Thymol attenuates the worsening of atopic dermatitis induced by Staphylococcus aureus membrane vesicles. Int Immunopharmacol. 2018;59:301-309 pubmed publisher
    ..aureus MVs, and reduced the serum levels of immunoglobulin (Ig) G2a, mite-specific IgE, and total IgE. In summary, thymol disrupts S...
  4. Gao Z, Zhou J, Zhang J, Ding Y, Liu Y. The silent point mutations at the cleavage site of 2A/2B have no effect on the self-cleavage activity of 2A of foot-and-mouth disease virus. Infect Genet Evol. 2014;28:101-6 pubmed publisher
    ..polyprotein is 18 amino acids in length, and 2A self-cleavage site (2A/2B) contains a conserved amino acid motif G2A/P2B...
  5. Li C, Hao M, Cao Z, Ding W, Graves Deal R, Hu J, et al. Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Mol Biol Cell. 2007;18:3081-93 pubmed
    ..detected at the basolateral surface of Madin-Darby canine kidney (MDCK) cells expressing myristoylation-deficient (G2A) Naked2...
  6. Ru F, Banovcin P, Kollarik M. Acid sensitivity of the spinal dorsal root ganglia C-fiber nociceptors innervating the guinea pig esophagus. Neurogastroenterol Motil. 2015;27:865-74 pubmed publisher
    ..Other evaluated targets (PKD2L1, TRPV4, TASK3, TALK1, G2A, GPR4, and TDAG8) were expressed rarely...
  7. Riemann A, Ihling A, Thomas J, Schneider B, Thews O, Gekle M. Acidic environment activates inflammatory programs in fibroblasts via a cAMP-MAPK pathway. Biochim Biophys Acta. 2015;1853:299-307 pubmed publisher
  8. Shevlin E, Miggin S. The TIR-domain containing adaptor TRAM is required for TLR7 mediated RANTES production. PLoS ONE. 2014;9:e107141 pubmed publisher
    ..Additionally, TRAM-G2A dose-dependently inhibited TLR7 mediated activation of CCL5, IFNβ and IFNα reporter genes...
  9. Liu C, Kanamaru Y, Watanabe T, Tada N, Horikoshi S, Suzuki Y, et al. Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice. Clin Exp Immunol. 2015;181:407-16 pubmed publisher
    ..This effect was associated with reduced serum titres of immunoglobulin (Ig)G2a but not IgG1, IgG2b and IgG3...

More Information

Publications65

  1. Li C, Ning C, Hagelberg E, Li H, Zhao Y, Li W, et al. Analysis of ancient human mitochondrial DNA from the Xiaohe cemetery: insights into prehistoric population movements in the Tarim Basin, China. BMC Genet. 2015;16:78 pubmed publisher
    ..maternal lineages, including West Eurasian lineages H, K, U5, U7, U2e, T, R*, East Eurasian lineages B, C4, C5, D, G2a and Indian lineage M5...
  2. Ichijo Y, Mochimaru Y, Azuma M, Satou K, Negishi J, Nakakura T, et al. Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment. Biochem Biophys Res Commun. 2016;469:81-86 pubmed publisher
    Human G2A is activated by various stimuli such as lysophosphatidylcholine (LPC), 9-hydroxyoctadecadienoic acid (9-HODE), and protons...
  3. Yu J, Wu X, Yan J, Yu H, Xu L, Chi Z, et al. Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients. J Hematol Oncol. 2018;11:1 pubmed publisher
    ..47.1 months, P?<?0.001). In the present study, CAR was constructed using a GD2-specific scFv (14.G2a), T cell receptor CD3? chain, and the CD137 (4-1BB) costimulatory motif. In addition, the GD2...
  4. Zuo Q, Zhao R, Liu J, Zhao Q, Zhu L, Zhang B, et al. Epidemiology and phylogeny of spike gene of porcine epidemic diarrhea virus from Yunnan, China. Virus Res. 2018;249:45-51 pubmed publisher
    ..The nine Yunnan isolates were clustered into classical G1b and pandemic G2a groups, indicating new variants have been emerging in Yunnan province...
  5. Bartlett S, Jacka B, Bull R, Luciani F, Matthews G, Lamoury F, et al. HIV infection and hepatitis C virus genotype 1a are associated with phylogenetic clustering among people with recently acquired hepatitis C virus infection. Infect Genet Evol. 2016;37:252-8 pubmed publisher
    ..ATAHC, n=113; HITS-p, n=90; and HITS-c, n=22), HCV genotype prevalence was: G1a: 38% (n=86), G1b: 5% (n=12), G2a: 1% (n=2), G2b: 5% (n=11), G3a: 48% (n=109), G6a: 1% (n=2) and G6l 1% (n=3)...
  6. Cohen L, Kang H, Chu J, Huang Y, Gordon E, Reddy B, et al. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc Natl Acad Sci U S A. 2015;112:E4825-34 pubmed publisher
    ..of G-protein-coupled receptors (GPCRs), which led us to the observation that commendamide activates the GPCR G2A/GPR132. G2A has been implicated in disease models of autoimmunity and atherosclerosis...
  7. Tobo A, Tobo M, Nakakura T, Ebara M, Tomura H, Mogi C, et al. Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses. PLoS ONE. 2015;10:e0129334 pubmed publisher
    ..In the cells that express proton-sensing GPCRs, including GPR4, OGR1, TDAG8, and G2A, extracellular acidification stimulates serum responsive element (SRE)-driven transcriptional activity, which has ..
  8. Shin S, Lee J, Lee H, Chang S, Chung S. Rapamycin attenuates Th2-driven experimental allergic conjunctivitis. Clin Immunol. 2018;190:1-10 pubmed publisher
    ..Rapamycin administration intraperitoneally markedly reduced clinical signs, total and OVA-specific IgE and IgG1/G2a ratio in serum, and conjunctival eosinophilic infiltration...
  9. Moriya K, Kimoto M, Matsuzaki K, Kiwado A, Takamitsu E, Utsumi T. Identification of dually acylated proteins from complementary DNA resources by cell-free and cellular metabolic labeling. Anal Biochem. 2016;511:1-9 pubmed publisher
    ..Metabolic labeling experiments using G2A and C7S mutants of EEPD1-EGFP revealed that the palmitoylation site of EEPD1 is Cys at position 7...
  10. Tan M, Yamaguchi S, Yamahira S, Nakamura M, Nagamune T. Quantitative image cytometry for analyzing intracellular trafficking of G protein-coupled receptors on a chemical-trapping single cell array. Lab Chip. 2017;17:1933-1938 pubmed publisher
    ..We quantified the intracellular distribution changes of a pH-dependent GPCR, G2A, by time-course observation under mildly acidic and slightly basic pH conditions...
  11. Vangaveti V, Shashidhar V, Rush C, Malabu U, Rasalam R, Collier F, et al. Hydroxyoctadecadienoic acids regulate apoptosis in human THP-1 cells in a PPARγ-dependent manner. Lipids. 2014;49:1181-92 pubmed publisher
    ..Their action is PPARγ-dependent and independent of GPR132. Further studies to identify the signalling pathways through which HODEs increase apoptosis in macrophages may reveal novel therapeutic targets for atherosclerosis. ..
  12. Frasch S, McNamee E, Kominsky D, Jedlicka P, Jakubzick C, Zemski Berry K, et al. G2A Signaling Dampens Colitic Inflammation via Production of IFN-?. J Immunol. 2016;197:1425-34 pubmed publisher
    ..for lysophosphatidylcholine, a lipid product of cellular injury, signaling via the G protein-coupled receptor G2A on myeloid and lymphoid inflammatory cells...
  13. Zeng M, Nourishirazi E, Guinet E, Nouri Shirazi M. The genetic background influences the cellular and humoral immune responses to vaccines. Clin Exp Immunol. 2016;186:190-204 pubmed publisher
    ..with alum, all adjuvants induced the recruitment of B cells and production of OVA-specific immunoglobulin (Ig)G2a more effectively in both strains...
  14. Kostyuk V, Potapovich A, Stancato A, De Luca C, Lulli D, Pastore S, et al. Photo-oxidation products of skin surface squalene mediate metabolic and inflammatory responses to solar UV in human keratinocytes. PLoS ONE. 2012;7:e44472 pubmed publisher
    ..responses characteristic for UVA+UVB, acting via AhR, EGFR, and G-protein-coupled arachidonic acid receptor (G2A)...
  15. Martin A, Steurer M, Aronstam R. Constitutive Activity among Orphan Class-A G Protein Coupled Receptors. PLoS ONE. 2015;10:e0138463 pubmed publisher
    ..These results suggest that identification of inverse agonists may be a fruitful approach for categorizing these orphan receptors and targeting them for pharmacological intervention. ..
  16. Zhou H, Xiong L, Wang Y, Ding L, Hu S, Zhao M, et al. Treatment of murine lupus with PD-LIg. Clin Immunol. 2016;162:1-8 pubmed publisher
    ..linking the extracellular domains of murine PD-1, PD-L1 and PD-L2 to the Fc portion of a mouse immunoglobulin G2a monoclonal antibody were generated and characterized...
  17. Su X, Wang M, Wu Y, He Y, Fu Z. Specific chemiluminescent protocol for dual-site recognition of Streptococcus mutans utilizing strong affinity between teicoplanin and Gram-positive bacteria. Talanta. 2018;179:350-355 pubmed publisher
    ..To achieve ideal specificity for S. mutans detection, rat immunoglobulin G2a (rat IgG2a) tagged with horseradish peroxidase (HRP) was used as the second recognition agent and signal tracer ..
  18. Lee H, Kim B, Shin S, Kim T, Chung S. Superoxide dismutase 3 attenuates experimental Th2-driven allergic conjunctivitis. Clin Immunol. 2017;176:49-54 pubmed publisher
    ..Clinical signs associated with conjunctivitis, such as OVA-specific IgE production, IgG1/G2a ratio and eosinophil infiltration, were drastically reduced in mice treated with SOD3...
  19. Hohmann S, Angioni C, Tunaru S, Lee S, Woolf C, Offermanns S, et al. The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity. Sci Rep. 2017;7:446 pubmed publisher
    ..Here, we report the involvement of the G-protein coupled receptor G2A (GPR132) in oxaliplatin-induced neuropathic pain in mice...
  20. Cheng W, Huynh H, Chen P, Peña Llopis S, Wan Y. Macrophage PPAR? inhibits Gpr132 to mediate the anti-tumor effects of rosiglitazone. elife. 2016;5: pubmed publisher
    ..These findings uncover macrophage PPAR? and Gpr132 as critical TAM modulators, new cancer therapeutic targets, and essential mediators of TZD anti-cancer effects. ..
  21. Chung H, Lee J, Nguyen V, Huynh T, Lee G, Moon H, et al. New emergence pattern with variant porcine epidemic diarrhea viruses, South Korea, 2012-2015. Virus Res. 2016;226:14-19 pubmed publisher
    ..While classical G1 was continuingly circulating between provinces of Korea, the pandemic G2a were recently introduced from China and USA...
  22. Abdelhalim M. Alterations in Gold Nanoparticle Levels Are Size Dependent, with the Smaller Ones Inducing the Most Toxic Effects and Related to the Time of Exposure of the Gold Nanoparticles. West Indian Med J. 2015;65:87-92 pubmed publisher
    ..into five groups, NG = control group, G1A: infusion of 10 nm GNPs for three days, G1B: 10 nm GNPs for seven days, G2A: 50 nm GNPs for three days and G2B: 50 nm GNPs for seven days...
  23. Lund M, Egerod K, Engelstoft M, Dmytriyeva O, Theodorsson E, Patel B, et al. Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites. Mol Metab. 2018;11:70-83 pubmed publisher
    ..In contrast, colonic EC cells are able to sense a multitude of different metabolites generated by the gut microbiota as well as gut hormones, including GLP-1. ..
  24. Chen P, Martinez Pena y Valenzuela I, Aittaleb M, Akaaboune M. AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice. J Neurosci. 2016;36:5680-5 pubmed publisher
    ..When N-myristoylation-defective rapsyn-EGFP mutant (G2A) and RING-H2 domain truncated rapsyn-EGFP were electroporated into sternomastoid muscles, a strong rapsyn ..
  25. Li H, Gu X, Li B, Chen C, Lin H, Xia J. Genome-Wide QTL Analysis Identified Significant Associations Between Hypoxia Tolerance and Mutations in the GPR132 and ABCG4 Genes in Nile Tilapia. Mar Biotechnol (NY). 2017;19:441-453 pubmed publisher
    ..Our data supply a basis for further marker-assisted selection of super lines with a high level of tolerance against low oxygen stress in the tilapia. ..
  26. Lim S, Kim M, Randy A, Nam E, Nho C. Effects of Hovenia dulcis Thunb. extract and methyl vanillate on atopic dermatitis-like skin lesions and TNF-?/IFN-?-induced chemokines production in HaCaT cells. J Pharm Pharmacol. 2016;68:1465-1479 pubmed publisher
    ..In-vivo studies showed that HDB regulated immunoglobulin (Ig) E and immunoglobulin G2a (IgG2a) levels in serum and the expression of mRNA for Th1- and Th2-related mediators in skin lesions...
  27. Nakajima Y, Kiyonari H, Mukumoto Y, Yokoyama T. The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6. Kidney Int. 2018;93:1108-1117 pubmed publisher
    ..Here we created and analyzed mutant mice (G2A mice) with a defective cilia localization signal in the Nphp3 gene...
  28. Weiß K, Fante M, Köhl G, Schreml J, Haubner F, Kreutz M, et al. Proton-sensing G protein-coupled receptors as regulators of cell proliferation and migration during tumor growth and wound healing. Exp Dermatol. 2017;26:127-132 pubmed publisher
    ..The proton-sensing G protein-coupled receptors (GPCRs) GPR4, GPR65 (TDAG8), GPR68 (OGR1) and GPR132 (G2A) are activated via a decrease in pHe and transduce this signal to molecular intracellular pathways...
  29. Shao J, Liu X, Ly H, Liang Y. Characterization of the Glycoprotein Stable Signal Peptide in Mediating Pichinde Virus Replication and Virulence. J Virol. 2016;90:10390-10397 pubmed
    ..The G2A mutation caused a marked reduction of cell entry at the membrane fusion step, and while this mutant virus was ..
  30. Park A, Agak G, Qin M, Hisaw L, Pirouz A, Kao S, et al. G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes. Ann Dermatol. 2017;29:688-698 pubmed publisher
    ..Here, we explore a possible mechanism by which a lipid receptor, G2A, regulates immune responses to a commensal bacterium.
  31. Lum H, Qiao J, Walter R, Huang F, Subbaiah P, Kim K, et al. Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. Am J Physiol Heart Circ Physiol. 2003;285:H1786-9 pubmed
    ..cells (HMEC) were prepared for RT-PCR analysis for possible expression of the G protein-coupled receptors, GPR4 and G2A, which are believed to be specific LPC receptors...
  32. Ogawa A, Obinata H, Hattori T, Kishi M, Tatei K, Ishikawa O, et al. Identification and analysis of two splice variants of human G2A generated by alternative splicing. J Pharmacol Exp Ther. 2010;332:469-78 pubmed publisher
    b>G2A is a G protein-coupled receptor that can be induced by various stressors. G2A is reported to have proton-sensing activity that mediates intracellular inositol phosphate (IP) accumulation with decreasing pH...
  33. Ellison M, Ambruso D, Silliman C. Therapeutic options for transfusion related acute lung injury; the potential of the G2A receptor. Curr Pharm Des. 2012;18:3255-9 pubmed
    ..Lyso- PCs prime PMNs activating the G2A receptor and several inhibitors of this receptor, which could potentially be therapeutic in TRALI, have been ..
  34. Li Y, Xu Y, Lai Y, Liao S, Liu N, Xu P. Intranasal co-administration of 1,8-cineole with influenza vaccine provide cross-protection against influenza virus infection. Phytomedicine. 2017;34:127-135 pubmed publisher
    ..5?mg/kg 1,8-cineole increased the production of influenza-specific serum immunoglobulin (Ig) G2a antibodies, stimulated mucosal secretive IgA (s-IgA) responses at the nasal cavity, improved the expression of ..
  35. Bond J, Domaschenz R, Roman Trufero M, Sabbattini P, Ferreiros Vidal I, Gerrard G, et al. Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia. Oncotarget. 2016;7:65923-65936 pubmed publisher
    ..We also identify the Gpr132 gene, which encodes the orphan G protein-coupled receptor G2A, as a novel target for Foxp1...
  36. Obinata H, Hattori T, Nakane S, Tatei K, Izumi T. Identification of 9-hydroxyoctadecadienoic acid and other oxidized free fatty acids as ligands of the G protein-coupled receptor G2A. J Biol Chem. 2005;280:40676-83 pubmed
    b>G2A is a G protein-coupled receptor that is predominantly expressed in lymphoid tissues and macrophages. G2A can be induced by diverse stimuli to cause cell cycle arrest in the G(2)/M phase in pro-B and T cells...
  37. York J, Nunberg J. Myristoylation of the Arenavirus Envelope Glycoprotein Stable Signal Peptide Is Critical for Membrane Fusion but Dispensable for Virion Morphogenesis. J Virol. 2016;90:8341-50 pubmed publisher
    ..Junín viruses (Candid #1 isolate) in which the critical glycine-2 residue in SSP was either replaced by alanine (G2A) or deleted (?G2)...
  38. Peter C, Waibel M, Radu C, Yang L, Witte O, Schulze Osthoff K, et al. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem. 2008;283:5296-305 pubmed
    ..Furthermore, using RNA interference and expression studies, we demonstrate that the G-protein-coupled receptor G2A, unlike its relative GPR4, is involved in the chemotaxis of monocytic cells...
  39. Murakami N, Yokomizo T, Okuno T, Shimizu T. G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J Biol Chem. 2004;279:42484-91 pubmed
    b>G2A (from G2 accumulation) is a G-protein-coupled receptor (GPCR) that regulates the cell cycle, proliferation, oncogenesis, and immunity...
  40. Li W, Zhang W, Deng M, Loughran P, Tang Y, Liao H, et al. Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation. Shock. 2017;: pubmed publisher
    ..significantly decreased caspase-11 activation and pyroptosis induced by LPS plus CTB independent of the receptor G2A. Stearoyl LPC did not affect LPS uptake by mouse peritoneal macrophages but, did significantly inhibit the ..
  41. Huang Y, Su Y, Chang C, Sun W. Heteromerization of G2A and OGR1 enhances proton sensitivity and proton-induced calcium signals. J Recept Signal Transduct Res. 2016;36:633-644 pubmed
    Proton-sensing G-protein-coupled receptors (GPCRs; OGR1, GPR4, G2A, TDAG8), with full activation at pH 6.4 ? 6.8, are important to pH homeostasis, immune responses and acid-induced pain...
  42. Hattori T, Obinata H, Ogawa A, Kishi M, Tatei K, Ishikawa O, et al. G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid. J Invest Dermatol. 2008;128:1123-33 pubmed
    b>G2A is a stress-inducible G protein-coupled receptor for oxidized free fatty acids, such as 9-hydroxyoctadecadienoic acid (HODE)...
  43. Chen P, Zuo H, Xiong H, Kolar M, Chu Q, Saghatelian A, et al. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A. 2017;114:580-585 pubmed publisher
    ..These findings uncover the lactate-Gpr132 axis as a driver of breast cancer metastasis by stimulating tumor-macrophage interplay, and reveal potential new therapeutic targets for breast cancer treatment. ..
  44. Weng Z, Fluckiger A, Nisitani S, Wahl M, Le L, Hunter C, et al. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Proc Natl Acad Sci U S A. 1998;95:12334-9 pubmed
    ..We have isolated an anti-proliferative cell cycle regulator named G2A (for G2 accumulation), which is predominantly expressed in immature T and B lymphocyte progenitors and is a member ..
  45. Hofacre A, Yagiz K, Mendoza D, Lopez Espinoza F, Munday A, Burrascano C, et al. Efficient Therapeutic Protein Expression Using Retroviral Replicating Vector with 2A Peptide in Cancer Models. Hum Gene Ther. 2017;: pubmed publisher
    ..Our data showed that GSG-linked 2A (g2A) peptide resulted in higher polyprotein separation efficiency than non-GSG linked 2A peptide...
  46. Frasch S, Zemski Berry K, Murphy R, Borregaard N, Henson P, Bratton D. Lysophospholipids of different classes mobilize neutrophil secretory vesicles and induce redundant signaling through G2A. J Immunol. 2007;178:6540-8 pubmed
    ..has been shown to enhance neutrophil functions through a mechanism involving the G protein-coupled receptor G2A. Recent data support an indirect effect of lysophosphatidylcholine on G2A rather than direct ligand binding...
  47. Radu C, Nijagal A, McLaughlin J, Wang L, Witte O. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A. 2005;102:1632-7 pubmed
    b>G2A, T cell death-associated gene 8 (TDAG8), ovarian cancer G protein-coupled receptor 1 (OGR1), and G protein-coupled receptor 4 (GPR4) form a group of structurally related G protein-coupled receptors (GPCRs) originally proposed to bind ..
  48. Freeman L, Guo H, David C, Brickey W, JHA S, Ting J. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214:1351-1370 pubmed publisher
    ..reduction in astrogliosis and microglial accumulation accompanied by decreased expression of the LPC receptor G2A, whereas MS patient samples show increased G2A...
  49. Khan S, McLaughlin N, Kelher M, Eckels P, Gamboni Robertson F, Banerjee A, et al. Lysophosphatidylcholines activate G2A inducing G(?i)??-/G(?q/)??- Ca²(+) flux, G(??)-Hck activation and clathrin/?-arrestin-1/GRK6 recruitment in PMNs. Biochem J. 2010;432:35-45 pubmed publisher
    ..Because the G2A receptor, expressed on PMNs, has been reported to recognize lyso-PCs, we hypothesize that lyso-PC activation of G2A ..
  50. Lin P, Ye R. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. J Biol Chem. 2003;278:14379-86 pubmed
    b>G2A, a G protein-coupled receptor for which lysophosphatidylcholine (LPC) is a high affinity ligand, belongs to a newly defined lysophospholipid receptor subfamily...
  51. Rikitake Y, Hirata K, Yamashita T, Iwai K, Kobayashi S, Itoh H, et al. Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 2002;22:2049-53 pubmed
    ..Recently, an orphan G-protein-coupled receptor, G2A, has been identified as a high-affinity receptor for LPC...
  52. Dogan S, Ašić A, Doğan G, Bešić L, Marjanovic D. Y-Chromosome Haplogroups in the Bosnian-Herzegovinian Population Based on 23 Y-STR Loci. Hum Biol. 2016;88:201-209 pubmed
    ..Remaining haplogroups were J2a (5%), I1 (4%), R1b (4%), J2b (2%), G2a (1%), and N (1%)...
  53. Su Y, Huang Y, Wong J, Lee C, Hsieh W, Sun W. G2A as a Threshold Regulator of Inflammatory Hyperalgesia Modulates Chronic Hyperalgesia. J Mol Neurosci. 2018;64:39-50 pubmed publisher
    ..The receptor G2 accumulation (G2A), expressed in neurons and immune cells, responds to protons or oxidized free fatty acids such as 9-..
  54. Parks B, Srivastava R, Yu S, Kabarowski J. ApoE-dependent modulation of HDL and atherosclerosis by G2A in LDL receptor-deficient mice independent of bone marrow-derived cells. Arterioscler Thromb Vasc Biol. 2009;29:539-47 pubmed publisher
    Deletion of the lysophospholipid-sensitive receptor, G2A, in low-density lipoprotein receptor knockout (LDLR(-/-)) mice elevates plasma high-density lipoprotein (HDL) cholesterol and suppresses atherosclerosis...
  55. Kelher M, McLaughlin N, Banerjee A, Elzi D, Gamboni F, Khan S, et al. LysoPCs induce Hck- and PKC?-mediated activation of PKC? causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol. 2017;101:261-273 pubmed publisher
    ..LysoPCs cause ligation of the G2A receptor, cytosolic Ca2+ flux, and activation of Hck...
  56. Le L, Kabarowski J, Wong S, Nguyen K, Gambhir S, Witte O. Positron emission tomography imaging analysis of G2A as a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene. Cancer Cell. 2002;1:381-91 pubmed
    b>G2A is a lymphocyte-expressed G protein-coupled receptor whose genetic ablation results in the development of autoimmunity...