FZD7

Summary

Gene Symbol: FZD7
Description: frizzled class receptor 7
Alias: FzE3, frizzled-7, Frizzled, drosophila, homolog of, 7, frizzled 7, seven transmembrane spanning receptor, frizzled family receptor 7, frizzled homolog 7, fz-7, hFz7
Species: human
Products:     FZD7

Top Publications

  1. Yang L, Wu X, Wang Y, Zhang K, Wu J, Yuan Y, et al. FZD7 has a critical role in cell proliferation in triple negative breast cancer. Oncogene. 2011;30:4437-46 pubmed publisher
    ..Overexpression of several Wnt pathway genes, such as frizzled homolog 7 (FZD7), low density lipoprotein receptor-related protein 6 and transcription factor 7 (TCF7) was observed in ..
  2. Vincan E, Darcy P, Farrelly C, Faux M, Brabletz T, Ramsay R. Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids. Oncogene. 2007;26:2340-52 pubmed
    ..Using RNAi, we demonstrate that FZD7 is necessary for MET of the monolayer cells as loss of FZD7 results in the persistence of a mesenchymal state (..
  3. Ueno K, Hazama S, Mitomori S, Nishioka M, Suehiro Y, Hirata H, et al. Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer. 2009;101:1374-81 pubmed publisher
    ..We previously reported that FZD7 functions as a receptor for the canonical Wnt signalling pathway in colon cancer cells...
  4. Sagara N, Toda G, Hirai M, Terada M, Katoh M. Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7. Biochem Biophys Res Commun. 1998;252:117-22 pubmed
    cDNAs for three human Wnt receptors, Frizzled-1 (FZD1), Frizzled-2 (FZD2), and Frizzled-7 (FZD7), have now been cloned and characterized. The FZD1, FZD2, and FZD7 genes encode the 647-, 565-, and 574-amino-acid proteins, respectively...
  5. Vincan E, Darcy P, Smyth M, Thompson E, Thomas R, Phillips W, et al. Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth. Differentiation. 2005;73:142-53 pubmed
    ..Using the ectodomain as an antagonist we have modulated endogenous FZD7 signalling in the moderately differentiated colon adenocarcinoma cell line, SK-CO-1...
  6. Wei W, Chua M, Grepper S, So S. Soluble Frizzled-7 receptor inhibits Wnt signaling and sensitizes hepatocellular carcinoma cells towards doxorubicin. Mol Cancer. 2011;10:16 pubmed publisher
    ..Recent studies have identified the Frizzled-7 receptor (FZD7), important for activation of Wnt-mediated signaling, as a potential therapeutic target for HCC and other cancers...
  7. Tanaka S, Akiyoshi T, Mori M, Wands J, Sugimachi K. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals. Proc Natl Acad Sci U S A. 1998;95:10164-9 pubmed
    ..The FzE3 cDNA encodes a protein of 574 amino acids and shares high sequence homology with the human FzD2 gene particularly ..
  8. Ueno K, Hiura M, Suehiro Y, Hazama S, Hirata H, Oka M, et al. Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia. 2008;10:697-705 pubmed
    We investigated whether one of the Wnt receptors, frizzled-7 (FZD7), functions in the canonical Wnt signaling pathway of colorectal cancer (CRC) cells harboring an APC or CTNNB1 mutation and may be a potential therapeutic target for ..
  9. Vincan E, Flanagan D, Pouliot N, Brabletz T, Spaderna S. Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment. Dev Dyn. 2010;239:311-7 pubmed publisher
    ..b>FZD7 is a putative Wnt/beta-catenin target gene and although it is highly expressed in well-differentiated colorectal ..

More Information

Publications113 found, 100 shown here

  1. Yao R, Natsume Y, Noda T. MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene. 2004;23:6023-30 pubmed
    ..These results indicate that MAGI-3 functions as a scaffold protein for frizzled-4 and Ltap and regulates the JNK signaling cascade. ..
  2. Kim M, Lee H, Tsedensodnom O, Hartley R, Lim Y, Yu E, et al. Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol. 2008;48:780-91 pubmed publisher
    ..We previously demonstrated that upregulation of Frizzled-7 receptor (FZD7) in HCC was associated with nuclear accumulation of wild-type beta-catenin...
  3. Melchior K, Weiss J, Zaehres H, Kim Y, Lutzko C, Roosta N, et al. The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells. Biol Chem. 2008;389:897-903 pubmed publisher
    ..The WNT receptor FZD7 was found among the genes with an ES cell-specific expression profile in both SAGE and microarray analyses...
  4. Mei H, Nakatsu M, Baclagon E, Deng S. Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells. Stem Cells. 2014;32:938-45 pubmed publisher
    ..Our finding suggests that Wnt signaling is one of the factors of LSC niche, and Fz7 helps to maintain the undifferentiated state of LSCs. ..
  5. Fernandez A, Huggins I, Perna L, Brafman D, Lu D, Yao S, et al. The WNT receptor FZD7 is required for maintenance of the pluripotent state in human embryonic stem cells. Proc Natl Acad Sci U S A. 2014;111:1409-14 pubmed publisher
    ..Here we examined the role of the WNT receptor FZD7 in maintaining human embryonic stem cells (hESCs) in an undifferentiated and pluripotent state...
  6. Luyten A, Mortier E, Van Campenhout C, Taelman V, Degeest G, Wuytens G, et al. The postsynaptic density 95/disc-large/zona occludens protein syntenin directly interacts with frizzled 7 and supports noncanonical Wnt signaling. Mol Biol Cell. 2008;19:1594-604 pubmed publisher
    ..Syntenin stimulates c-jun phosphorylation and modulates Frizzled 7 signaling, in particular the PKCalpha/CDC42 noncanonical Wnt signaling cascade...
  7. Nikaido M, Law E, Kelsh R. A systematic survey of expression and function of zebrafish frizzled genes. PLoS ONE. 2013;8:e54833 pubmed publisher
    ..Furthermore, we show that the two fzd7 genes function together with fzd10 to regulate epiboly movements and mesoderm differentiation.
  8. Götzel K, Chemnitzer O, Maurer L, Dietrich A, Eichfeld U, Lyros O, et al. In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett's sequence. BMC Gastroenterol. 2019;19:38 pubmed publisher
    ..analysis revealed a distinct expression pattern, showing the highest expression for Fzd2, Fzd3, Fzd4, Fzd5, Fzd7, and the co-receptor LRP5/6 in EAC cells, while Fzd3 and Fzd7 were rarely expressed in primary specimens from ..
  9. Flanagan D, Barker N, Costanzo N, Mason E, Gurney A, Meniel V, et al. Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations. Cancer Res. 2019;79:970-981 pubmed publisher
    ..Pharmacologic targeting of Fzd inhibited the growth of gastric adenomas in vivo. We identified Fzd7 to be the predominant Wnt receptor responsible for transmitting Wnt signaling in human gastric cancer cells and ..
  10. Flanagan D, Phesse T, Barker N, Schwab R, Amin N, Malaterre J, et al. Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells. Stem Cell Reports. 2015;4:759-67 pubmed publisher
    ..Here we show Fzd7 is enriched in Lgr5(+) stem cells and binds Wnt3 and Wnt2b...
  11. Xie W, Zhang Y, He Y, Zhang K, Wan G, Huang Y, et al. A novel recombinant human Frizzled-7 protein exhibits anti-tumor activity against triple negative breast cancer via abating Wnt/β-catenin pathway. Int J Biochem Cell Biol. 2018;103:45-55 pubmed publisher
    ..Frizzled-7 (Fzd7), one of the Wnt receptors, was significantly up-regulated in TNBC and modulated TNBC tumorigenesis through the Wnt ..
  12. Ding X, Zheng D, Fan C, Liu Z, Dong H, Lu Y, et al. Genome-wide screen of DNA methylation identifies novel markers in childhood obesity. Gene. 2015;566:74-83 pubmed publisher
    ..Furthermore, four genes (FZD7, PRLHR, EXOSC4, and EIF6) with differential promoter methylation were validated, and their associations with ..
  13. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, et al. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016;538:350-355 pubmed publisher
    ..Colonic organoids cultured from FZD7-knockout mice, combined with knockdown of FZD1 and 2, showed increased resistance to TcdB...
  14. Yuan K, Orcholski M, Panaroni C, Shuffle E, Huang N, Jiang X, et al. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. Am J Pathol. 2015;185:69-84 pubmed publisher
    ..PAH pericytes had reduced expression of frizzled 7 (Fzd7) and cdc42, genes crucial for Wnt/PCP activation...
  15. Hughes K, Sablitzky F, Mahida Y. Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Inflamm Bowel Dis. 2011;17:213-20 pubmed publisher
    ..Most of the myofibroblast isolates expressed Wnt2, Wnt5A, Wnt5B, Fzd1, Fzd2, Fzd4, Fzd6, Fzd7, Fzd8, LRP6, Dickkopf1, and SFRP1...
  16. Peghaire C, Bats M, Sewduth R, Jeanningros S, Jaspard B, Couffinhal T, et al. Fzd7 (Frizzled-7) Expressed by Endothelial Cells Controls Blood Vessel Formation Through Wnt/β-Catenin Canonical Signaling. Arterioscler Thromb Vasc Biol. 2016;36:2369-2380 pubmed
    ..Wnt/frizzled signaling is required for proper vascular formation. In this study, we investigated the role of the Fzd7 (frizzled-7) receptor in retinal vascular development and its relationship with the Wnt/β-catenin canonical ..
  17. Klopsch C, Skorska A, Ludwig M, Lemcke H, Maass G, Gaebel R, et al. Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart. Dis Model Mech. 2018;11: pubmed publisher
    ..in intramyocardial MSC niches through the direct activation of AKT and upregulation of upstream signals FOS and Fzd7, and augmented intracardiac mesenchymal proliferation 24 h after MI...
  18. Hoseth E, Krull F, Dieset I, Mørch R, Hope S, Gardsjord E, et al. Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Transl Psychiatry. 2018;8:55 pubmed publisher
    ..In particular, FZD7, which may activate all Wnt pathways, but favors non-canonical signaling, and NFATc3, a downstream transcription ..
  19. Winkler M, Dib C, Ljubimov A, Saghizadeh M. Targeting miR-146a to treat delayed wound healing in human diabetic organ-cultured corneas. PLoS ONE. 2014;9:e114692 pubmed publisher
    ..Furthermore, abnormal miR-146a upregulation may be an important mechanism of delayed wound healing in the diabetic cornea. ..
  20. Berger H, Breuer M, Peradziryi H, Podleschny M, Jacob R, Borchers A. PTK7 localization and protein stability is affected by canonical Wnt ligands. J Cell Sci. 2017;130:1890-1903 pubmed publisher
    ..PTK7 endocytosis is dependent on the presence of the PTK7 co-receptor Fz7 (also known as Fzd7) and results in lysosomal degradation of PTK7...
  21. Campos C, Hartling I, Kaur M, Fernandes A, Santos R, Cerri R. Intramammary infusion of lipopolysaccharide promotes inflammation and alters endometrial gene expression in lactating Holstein cows. J Dairy Sci. 2018;101:10440-10455 pubmed publisher
    ..49-fold increase; EMMPRIN = 1.20-fold increase; SELL = 1.91-fold increase), Wnt signaling pathway (WNT2, FZD4, and FZD7, all <1.5-fold increase), and interferon-stimulated genes (BMP15 = 0.27-fold decrease; ISG15 = 2...
  22. Kalhor H, Poorebrahim M, Rahimi H, Shabani A, Karimipoor M, Akbari Eidgahi M, et al. Structural and dynamic characterization of human Wnt2-Fzd7 complex using computational approaches. J Mol Model. 2018;24:274 pubmed publisher
    ..In this study, we suggest a possible interaction mode of Wnt2 with the Fzd7 cysteine-rich domain (CRD)-both of which are up-regulated in some types of cancer...
  23. Takahashi Y, Chen Q, Rajala R, Ma J. MicroRNA-184 modulates canonical Wnt signaling through the regulation of frizzled-7 expression in the retina with ischemia-induced neovascularization. FEBS Lett. 2015;589:1143-1149 pubmed publisher
    ..These results suggest that decreased levels of miR-184 are responsible, at least in part, for the aberrant activation of Wnt signaling in ischemia-induced retinal neovascularization. ..
  24. Flanagan D, Barker N, Nowell C, Clevers H, Ernst M, Phesse T, et al. Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo. Dis Model Mech. 2017;10:971-980 pubmed publisher
    ..of the gastric epithelium, but this has not been investigated in vivo Here, we show that the Wnt receptor frizzled 7 (Fzd7), which is required for the homeostasis of the intestine, is expressed in the gastric epithelium and is ..
  25. Tribulo P, Moss J, Ozawa M, Jiang Z, Tian X, Hansen P. WNT regulation of embryonic development likely involves pathways independent of nuclear CTNNB1. Reproduction. 2017;153:405-419 pubmed publisher
    ..different between ICM and TE, and all of them were overexpressed in TE as compared to ICM, including WNT6, FZD1, FZD7, LRP6, PORCN, APC and SFRP1 Immunoreactive CTNNB1 was localized primarily to the plasma membrane at all stages ..
  26. McLeod F, Bossio A, Marzo A, Ciani L, Sibilla S, Hannan S, et al. Wnt Signaling Mediates LTP-Dependent Spine Plasticity and AMPAR Localization through Frizzled-7 Receptors. Cell Rep. 2018;23:1060-1071 pubmed publisher
    ..We identify a critical role for Wnt-Fz7 signaling in LTP-mediated synaptic accumulation of AMPARs and spine plasticity. ..
  27. Schöttelndreier D, Seeger K, Grassl G, Winny M, Lindner R, Genth H. Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B. Front Microbiol. 2018;9:1483 pubmed publisher
    ..HIOs from four human donors exhibited a comparable profile of receptor expression, with PVRL3, LRP1, and FZD7 being expressed and CSPG4 and FZD2 not being expressed...
  28. Zarei N, Fazeli M, Mohammadi M, Nejatollahi F. Cell growth inhibition and apoptosis in breast cancer cells induced by anti-FZD7 scFvs: involvement of bioinformatics-based design of novel epitopes. Breast Cancer Res Treat. 2018;169:427-436 pubmed publisher
    b>FZD7 has a critical role as a surface receptor of Wnt/β-catenin signaling in cancer cells. Suppressing Wnt signaling through blocking FZD7 is shown to decrease cell viability, metastasis and invasion...
  29. Chen Z, Huang C, Ma T, Jiang L, Tang L, Shi T, et al. Reversal effect of quercetin on multidrug resistance via FZD7/?-catenin pathway in hepatocellular carcinoma cells. Phytomedicine. 2018;43:37-45 pubmed publisher
    ..Moreover, the suppression of ABCB1, ABCC1 and ABCC2 by quercetin was dependent on the FZD7 through the Wnt/?-catenin pathway...
  30. Sagar -, Pröls F, Wiegreffe C, Scaal M. Communication between distant epithelial cells by filopodia-like protrusions during embryonic development. Development. 2015;142:665-71 pubmed publisher
    ..Taken together, our data suggest a role of filopodia-like protrusions in mediating signaling events between distant epithelial cells during embryonic development. ..
  31. Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, et al. Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis. Am J Physiol Renal Physiol. 2016;311:F35-45 pubmed publisher
    ..We have shown prominent Wnt6 and frizzled 7 (FzD7) expression in the mesonephros of the developing mouse kidney, suggesting a role for Wnt6 in ..
  32. Nile A, De Sousa E Melo F, Mukund S, Piskol R, Hansen S, Zhou L, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018;14:582-590 pubmed publisher
    ..The Frizzled (FZD) 7 receptor (FZD7) is enriched in LGR5+ intestinal stem cells and plays a critical role in their self-renewal...
  33. Ferrari M, Bernis M, McLeod F, Podpolny M, Coullery R, Casadei I, et al. Wnt7b signalling through Frizzled-7 receptor promotes dendrite development by coactivating CaMKII and JNK. J Cell Sci. 2018;131: pubmed publisher
    ..Here, we identify the seven-transmembrane frizzled-7 (Fz7, also known as FZD7) as the receptor for Wnt7b-mediated dendrite growth and complexity...
  34. Quan H, Li B, Yang J. MicroRNA-504 functions as a tumor suppressor in hepatocellular carcinoma through inhibiting Frizzled-7-mediated-Wnt/β-catenin signaling. Biomed Pharmacother. 2018;107:754-762 pubmed publisher
    ..Interestingly, bioinformatics analysis predicted that Frizzled-7 (FZD7) was a potential target gene of miR-504...
  35. Wang Y, Sun L, Wang L, Liu Z, Li Q, Yao B, et al. Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/?-catenin signal pathway in hepatocellular carcinoma. Cell Death Dis. 2018;9:851 pubmed publisher
    ..and loss-of-function studies showed that miR-485-5p activated Wnt/?-catenin signal pathway by targeting Frizzled-7 (FZD7). Moreover, DSCR8 activated Wnt/?-catenin signal pathway to promote HCC progression by DSCR8/miR-485-5p/FZD7 axis...
  36. Li Z, Chen P, Su R, Li Y, Hu C, Wang Y, et al. Overexpression and knockout of miR-126 both promote leukemogenesis. Blood. 2015;126:2005-15 pubmed publisher
    ..are highly expressed in committed, more differentiated hematopoietic progenitor cells, presumably through inducing FZD7 expression...
  37. Sartaj R, Zhang C, Wan P, Pasha Z, Guaiquil V, Liu A, et al. Characterization of slow cycling corneal limbal epithelial cells identifies putative stem cell markers. Sci Rep. 2017;7:3793 pubmed publisher
    ..cell RNA-Seq to identify genes representing common putative stem cell markers or determinants, which included Sox9, Fzd7, Actn1, Anxa3 and Krt17...
  38. Hering H, Sheng M. Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95. FEBS Lett. 2002;521:185-9 pubmed
  39. Duffy D, Krstic A, Halasz M, Schwarzl T, Konietzny A, Iljin K, et al. Retinoic acid and TGF-? signalling cooperate to overcome MYCN-induced retinoid resistance. Genome Med. 2017;9:15 pubmed publisher
    ..regulation of RA and MYCN on a number of differentiation-relevant genes, including LMO4, CYP26A1, ASCL1, RET, FZD7 and DKK1...
  40. Wald J, Hatakeyama J, Printsev I, Cuevas A, Fry W, Saldana M, et al. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene. 2017;36:5158-5167 pubmed publisher
    ..components of the planar cell polarity (PCP) arm of non-canonical Wnt signaling including VANGL1, VANGL2 and FZD7 are transcriptionally upregulated in glioma and correlate with poorer patient outcome...
  41. Golenia G, Gatie M, Kelly G. Frizzled gene expression and negative regulation of canonical WNT-β-catenin signaling in mouse F9 teratocarcinoma cells. Biochem Cell Biol. 2017;95:251-262 pubmed publisher
    ..Eight of the 10 Fzd genes were found to be expressed in F9 cells, with Fzd7 being the most highly expressed, and chosen for further analysis...
  42. von Maltzahn J, Renaud J, Parise G, Rudnicki M. Wnt7a treatment ameliorates muscular dystrophy. Proc Natl Acad Sci U S A. 2012;109:20614-9 pubmed publisher
    ..Wnt7a signaling through its receptor Fzd7 accelerates and augments regeneration by stimulating satellite stem cell expansion through the planar cell polarity ..
  43. Nile A, Mukund S, Stanger K, Wang W, Hannoush R. Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc Natl Acad Sci U S A. 2017;114:4147-4152 pubmed publisher
    ..Here, we determined a crystal structure of human FZD7 CRD unexpectedly bound to a 24-carbon fatty acid...
  44. Cheng Z, Song Y, Wang Z, Wang Y, Dong Y. miR-144-3p serves as a tumor suppressor by targeting FZD7 and predicts the prognosis of human glioblastoma. Eur Rev Med Pharmacol Sci. 2017;21:4079-4086 pubmed
    ..and luciferase assays were employed to identify the predicted microRNA (miRNA) which regulates Frizzled-7 (FZD7). The levels of FZD7 and FZD7 mRNA were determined by Western blot and RT-PCR...
  45. Condello S, Sima L, Ivan C, Cárdenas H, Schiltz G, Mishra R, et al. Tissue Tranglutaminase Regulates Interactions between Ovarian Cancer Stem Cells and the Tumor Niche. Cancer Res. 2018;78:2990-3001 pubmed publisher
    ..TG2 and the Wnt receptor Frizzled 7 (Fzd7) form a complex in cancer cells and tumors, leading to Wnt pathway activation...
  46. Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, et al. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength. J Cell Biol. 2014;205:97-111 pubmed publisher
    Wnt7a/Fzd7 signaling stimulates skeletal muscle growth and repair by inducing the symmetric expansion of satellite stem cells through the planar cell polarity pathway and by activating the Akt/mTOR growth pathway in muscle fibers...
  47. Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher
    ..SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulated genes included OCLN, TJP1 (ZO-1), FZD7, CDH1 (E-cadherin), and LAMA5...
  48. Ahmed R, Alawin O, Sylvester P. ?-Tocotrienol reversal of epithelial-to-mesenchymal transition in human breast cancer cells is associated with inhibition of canonical Wnt signalling. Cell Prolif. 2016;49:460-70 pubmed publisher
    Frizzled-7 (FZD7) receptor-dependent activation of the canonical Wnt/?-catenin pathway plays a crucial role in epithelial-to-mesenchymal transition (EMT) and breast cancer metastasis...
  49. Leung C, Mak W, Kai A, Chan K, Lee T, Ng I, et al. Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/?-catenin signaling. Oncotarget. 2016;7:29371-86 pubmed publisher
    ..By ChIP and luciferase promoter assays, Frizzled-7 was identified to be the direct transcriptional target of Sox9. In conclusion, Sox9 confers stemness properties of HCC through Frizzled-7 mediated Wnt/?-catenin pathway. ..
  50. Mebarki S, Désert R, Sulpice L, Sicard M, Desille M, Canal F, et al. De novo HAPLN1 expression hallmarks Wnt-induced stem cell and fibrogenic networks leading to aggressive human hepatocellular carcinomas. Oncotarget. 2016;7:39026-39043 pubmed publisher
    ..Invasion was inhibited by 30 nM FZD7 and FZD8 CRDs...
  51. Liu T, Hu K, Zhao Z, Chen G, Ou X, Zhang H, et al. MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway. Oncotarget. 2015;6:41638-49 pubmed publisher
    ..Enhanced miR-1 expression significantly reduced the Frizzled 7 and Tankyrase-2 (TNKS2)-regulated luciferase activity in 293T cells and decreased Frizzled 7, TNKS2, c-Myc, ..
  52. Brinkmann E, Mattes B, Kumar R, Hagemann A, Gradl D, Scholpp S, et al. Secreted Frizzled-related Protein 2 (sFRP2) Redirects Non-canonical Wnt Signaling from Fz7 to Ror2 during Vertebrate Gastrulation. J Biol Chem. 2016;291:13730-42 pubmed publisher
    ..We further provide evidence that sFRP2 redirects non-canonical Wnt signaling from Frizzled 7 (Fz7) to the receptor tyrosine kinase-like orphan receptor 2 (Ror2)...
  53. Hahn J, McFarland K, Combs K, Supp D. Partial epithelial-mesenchymal transition in keloid scars: regulation of keloid keratinocyte gene expression by transforming growth factor-?1. Burns Trauma. 2016;4:30 pubmed publisher
    ..including hyaluronan synthase 2, vimentin, cadherin-11, wingless-type MMTV integration site family, member 5A, frizzled 7, ADAM metallopeptidase domain 19, and interleukin-6...
  54. Huang M, Wu S, Hu Q, Wu H, Wei S, Xie H, et al. Agkihpin, a novel SVAE may inhibit the migration and invasion of liver cancer cells associated with the inversion of EMT induced by Wnt/?-catenin signaling inhibition. Biochem Biophys Res Commun. 2016;479:283-289 pubmed publisher
    ..cells; canonical Wnt/?-catenin pathway, one of the signals initiated EMT, was inhibited by decreased expressions of FZD7 and ?-catenin, phosphorylation of GSK3? (Ser9), and nuclear ?-catenin accumulation in agkihpin treated cancer cells...
  55. Nickho H, Younesi V, Aghebati Maleki L, Motallebnezhad M, Majidi Zolbanin J, Movassagh Pour A, et al. Developing and characterization of single chain variable fragment (scFv) antibody against frizzled 7 (Fzd7) receptor. Bioengineered. 2017;8:501-510 pubmed publisher
    ..Overexpression of Wnt pathway genes, such as Fzd7 in several malignancies is well-documented...
  56. Hamdoun S, Fleischer E, Klinger A, Efferth T. Lawsone derivatives target the Wnt/?-catenin signaling pathway in multidrug-resistant acute lymphoblastic leukemia cells. Biochem Pharmacol. 2017;146:63-73 pubmed publisher
    ..was the most active compound and dose-dependently down-regulated protein expression of ?-catenin, c-MYC, Pgp and Frizzled 7. By molecular docking, we predicted that compound (1) bound to the palmitoyl-binding groove of the cysteine-rich ..
  57. Aznar N, Ear J, Dunkel Y, Sun N, Satterfield K, He F, et al. Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple. Sci Signal. 2018;11: pubmed publisher
    ..the Wnt/FZD mediator Dishevelled (Dvl), and it enhances β-catenin-independent Wnt signaling in response to Wnt5a-FZD7 signaling...
  58. Liu X, Yan Y, Ma W, Wu S. Knockdown of frizzled-7 inhibits cell growth and metastasis and promotes chemosensitivity of esophageal squamous cell carcinoma cells by inhibiting Wnt signaling. Biochem Biophys Res Commun. 2017;490:1112-1118 pubmed publisher
    A growing body of evidence suggests that frizzled-7 (FZD7) is an important oncogene in multiple human malignancies and is involved in regulating sensitivity to chemotherapeutic drugs...
  59. Kwon H, Lee H, Ji Y, Rubin J, Tomarev S. Myocilin is a modulator of Wnt signaling. Mol Cell Biol. 2009;29:2139-54 pubmed publisher
    ..Myocilin and Wnt proteins may perform redundant functions in the mammalian eye, since myocilin modulates Wnt signaling by interacting with components of this signaling pathway. ..
  60. Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, et al. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 2015;6:6380 pubmed publisher
    ..The pro-carcinogenic role of Epsins suggests that they are potential therapeutic targets to combat colon cancer. ..
  61. Zhang W, Lu W, Ananthan S, Suto M, Li Y. Discovery of novel frizzled-7 inhibitors by targeting the receptor's transmembrane domain. Oncotarget. 2017;8:91459-91470 pubmed publisher
    ..Of the 10 members of the Fzd family, Fzd7 is the most important member involved in cancer development and progression...
  62. Song J, Gao L, Yang G, Tang S, Xie H, Wang Y, et al. MiR-199a regulates cell proliferation and survival by targeting FZD7. PLoS ONE. 2014;9:e110074 pubmed publisher
    ..Furthermore, Frizzled type 7 receptor (FZD7), the most important Wnt receptor involved in cancer development and progression, was identified as a functional ..
  63. Omoto S, Hayashi T, Kitahara K, Takeuchi T, Ueoka Y. Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R). Ophthalmic Genet. 2004;25:81-90 pubmed
    ..Analysis of FZD4 mutations in families with adFEVR is useful for genetic counseling and for early diagnosis ..
  64. Sun L, Hu X, Chen W, He W, Zhang Z, Wang T. Sorting nexin 27 interacts with Fzd7 and mediates Wnt signalling. Biosci Rep. 2016;36:e00296 pubmed publisher
    ..Immunofluorescence microscopy revealed that Fzd7 can be internalized and associate with SNX27-containing endosomal membrane...
  65. Xu R, Zeng S, Xie W, Sun C, Chen Y, Chen M, et al. The expression and function of Frizzled-7 in human renal cell carcinoma. Clin Transl Oncol. 2016;18:269-76 pubmed publisher
    Wnt/β-catenin has emerged as an important signal pathway in renal cell carcinoma (RCC) pathogenesis. Frizzled 7 (Fzd7) is a member of Frizzled (Fzd) receptor family which binds with Wnt ligands and transduces canonical and non-..
  66. Li C, Chen H, Hu L, Xing Y, Sasaki T, Villosis M, et al. Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. BMC Mol Biol. 2008;9:11 pubmed publisher
    ..This activity of Ror2 is dependent on cooperative interactions with Fzd2 but not Fzd7. In addition, Ror2-mediated enhancement of canonical signaling requires the extracellular CRD, but not the ..
  67. Schiffgens S, Wilkens L, Brandes A, Meier T, Franceschi E, Ermani M, et al. Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma. Oncotarget. 2016;7:55169-55180 pubmed publisher
    The Wnt receptor Frizzled-7 (FZD7) promotes tumor progression and can be currently targeted by monoclonal antibody therapy...
  68. Punchihewa C, Ferreira A, Cassell R, Rodrigues P, Fujii N. Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci. 2009;18:994-1002 pubmed publisher
    ..Molecular modeling and circular dichroism studies indicated that the Fz peptides that bind to Dvl PDZ domain form specific conformations that are different from those of nonbinding peptides. ..
  69. Deng B, Zhang S, Miao Y, Zhang Y, Wen F, Guo K. Down-regulation of Frizzled-7 expression inhibits migration, invasion, and epithelial-mesenchymal transition of cervical cancer cell lines. Med Oncol. 2015;32:102 pubmed publisher
    Frizzled-7 (FZD7) has been demonstrated as a critical receptor of the Wnt signaling and involves in tumorigenesis and metastasis in many cancer types. However, limited information was found in cervical cancer...
  70. Liu N, Zang S, Liu Y, Wang Y, Li W, Liu Q, et al. FZD7 regulates BMSCs-mediated protection of CML cells. Oncotarget. 2016;7:6175-87 pubmed publisher
    ..In this study, we found that BMSCs increased the expression of FZD7 and activated Wnt/β-catenin signaling pathway in CML cells...
  71. Qiu X, Jiao J, Li Y, Tian T. Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ. Oncotarget. 2016;7:85987-85999 pubmed publisher
    ..Frizzled-7 (FZD7) is a seven-pass trans-membrane Wnt receptor that plays a critical role in the development of various tumors...
  72. Xu H, Gong L, Xia Y, Qu L, Li Q, Pang L, et al. Frizzled-7 promoter is highly active in tumors and promoter-driven Shiga-like toxin I inhibits hepatocellular carcinoma growth. Oncotarget. 2015;6:39908-23 pubmed publisher
    ..Moreover, cell proliferation and tumor growth decreased significantly after transfection with the pFZD7-Stx1. Results from this study will help determine a highly effective strategy for gene therapy of tumors. ..
  73. Simmons G, Pandey S, Nedeljkovic Kurepa A, Saxena M, Wang A, Pruitt K. Frizzled 7 expression is positively regulated by SIRT1 and ?-catenin in breast cancer cells. PLoS ONE. 2014;9:e98861 pubmed publisher
    ..that the use of small molecule inhibitors of SIRT1 and SIRT2, and siRNA specific to SIRT1, all reduce the levels of FZD7 mRNA...
  74. Bhat V, Sun Y, Weger S, Raouf A. Notch-Induced Expression of FZD7 Requires Noncanonical NOTCH3 Signaling in Human Breast Epithelial Cells. Stem Cells Dev. 2016;25:522-9 pubmed publisher
    ..we used gain of function and loss of function experiments and found that a Wnt signaling receptor, Frizzled7 (FZD7), is a unique and nonredundant target of NOTCH3 in human breast epithelial cells...
  75. Egea Jimenez A, Gallardo R, Garcia Pino A, Ivarsson Y, Wawrzyniak A, Kashyap R, et al. Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling. Nat Commun. 2016;7:12101 pubmed publisher
    ..Here we report a crystal structure of the syntenin PDZ tandem in complex with the carboxy-terminal fragment of Frizzled 7 and phosphatidylinositol 4,5-bisphosphate (PIP2)...
  76. Sun Y, Xu T, Cao Y, Ding X. Antitumor effect of miR-27b-3p on lung cancer cells via targeting Fzd7. Eur Rev Med Pharmacol Sci. 2017;21:4113-4123 pubmed
    ..We test the bonding effect of miR-27b-3p on the Fzd7 promoter, and miR-27b-3p effects on the Fzd7 expression in both NCI-H446 and A549 cells...
  77. Ren W, Li C, Duan W, Du S, Yang F, Zhou J, et al. MicroRNA-613 represses prostate cancer cell proliferation and invasion through targeting Frizzled7. Biochem Biophys Res Commun. 2016;469:633-8 pubmed publisher
    ..Frizzled7 (Fzd7), the most important receptor of the Wnt signaling pathway, is extensively involved in cancer development and ..
  78. Wu J, Li J, Ren J, Zhang D. MicroRNA-485-5p represses melanoma cell invasion and proliferation by suppressing Frizzled7. Biomed Pharmacother. 2017;90:303-310 pubmed publisher
    ..analysis, we observed that miR-485-5p potentially targets the 3'-untranslated region (3'-UTR) of Frizzled7 (FZD7). Dual-luciferase assay confirmed the direct binding between miR-485-5p and FZD7 3'-UTR...
  79. Abu Elmagd M, Mulvaney J, Wheeler G. Frizzled-7 is required for Xenopus heart development. Biol Open. 2017;6:1861-1868 pubmed publisher
    ..It is unclear which Frizzled proteins mediate these interactions. Frizzled-7 (fzd7) is expressed during gastrulation in the mesodermal cells fated to become heart, and then in the primary heart ..
  80. Wheeler D, Barrick S, Grubisha M, Brufsky A, Friedman P, Romero G. Direct interaction between NHERF1 and Frizzled regulates ?-catenin signaling. Oncogene. 2011;30:32-42 pubmed publisher
    ..Taken together, these results provide a novel insight into the regulation of Wnt signaling in normal and neoplastic breast tissues, and identify NHERF1 as an important regulator of the pathogenesis of breast tumors. ..
  81. Cao T, Xiang D, Liu B, Huang T, Tan B, Zeng C, et al. FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma. Oncotarget. 2017;8:65957-65968 pubmed publisher
    ..In this study, we found that the FZD7 gene was the most commonly up-regulated FZD member in ESCC cell lines compared with other FZDs...
  82. Song H, Nan Y, Wang X, Zhang G, Zong S, Kong X. MicroRNA?613 inhibits proliferation and invasion of renal cell carcinoma cells through targeting FZD7. Mol Med Rep. 2017;16:4279-4286 pubmed publisher
    ..Bioinformatics analysis showed that Frizzled7 (FZD7) was a predicted target of miR?613, which was verified by dual?luciferase reporter assay, reverse transcription ..
  83. Guan S, Zhou J. Frizzled-7 mediates TGF-?-induced pulmonary fibrosis by transmitting non-canonical Wnt signaling. Exp Cell Res. 2017;359:226-234 pubmed publisher
    ..We found that TGF-?1 treatment induces a marked upregulation of Frizzled-7 (FZD7) in human lung fibroblasts. FZD7 expression is also increased in animal models of TGF-?1-induced pulmonary fibrosis...
  84. de Cássia Viu Carrara R, Fontes A, Abraham K, Orellana M, Haddad S, Palma P, et al. Expression differences of genes in the PI3K/AKT, WNT/b-catenin, SHH, NOTCH and MAPK signaling pathways in CD34+ hematopoietic cells obtained from chronic phase patients with chronic myeloid leukemia and from healthy controls. Clin Transl Oncol. 2018;20:542-549 pubmed publisher
    ..We also identified five transcripts upregulated in CD34-CML patients named OSBPL9, MEK2, p90RSK, TCF4 and FZD7 that can be potential biomarkers in CD34-CML-CP...
  85. Dufourcq P, Leroux L, Ezan J, Descamps B, Lamazière J, Costet P, et al. Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. Am J Pathol. 2008;172:37-49 pubmed
    ..This study illustrates a regulated pathway by sFRP-1 involving GSK-3beta and Rac-1 in endothelial cell cytoskeletal reorganization and in neovessel formation. ..
  86. Geng Y, Lu X, Wu X, Xue L, Wang X, Xu J. MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7. Oncol Rep. 2016;35:2441-50 pubmed publisher
    MicroRNAs (miRNAs) are novel tools for cancer therapy. Frizzled7 (FZD7) is an important co-receptor in the WNT signaling pathway. The WNT signaling pathway is aberrantly activated in Helicobacter pylori (H...
  87. Lacour F, Vezin E, Bentzinger C, Sincennes M, Giordani L, Ferry A, et al. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Cell Rep. 2017;18:2320-2330 pubmed publisher
    ..in muscle fusion was dependent on downregulation of Wnt/β-catenin and upregulation of non-canonical Wnt7a/Fzd7/Rac1 signaling...
  88. Kim J, Kim H, Jee B, Suh C, Choi Y, Moon S. Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women. J Korean Med Sci. 2009;24:443-7 pubmed publisher
    ..The SNPs in the FZD1, FZD5, FZD6, FZD7, and FZD9 genes were analyzed by direct sequencing in 371 postmenopausal Korean women...
  89. Breitfeld J, Scholl C, Steffens M, Laje G, Stingl J. Gene expression and proliferation biomarkers for antidepressant treatment resistance. Transl Psychiatry. 2017;7:e1061 pubmed publisher
    ..Gene expression analysis of the candidate gene panel revealed and confirmed influence of the candidate genes ABCB1, FZD7 and WNT2B on antidepressant drug resistance...
  90. Chakrabarti R, Wei Y, Hwang J, Hang X, Andres Blanco M, Choudhury A, et al. ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling. Nat Cell Biol. 2014;16:1004-15, 1-13 pubmed publisher
    ..factor promotes normal mammary stem cell (MaSC) activity by increasing the expression of the Wnt receptor Fzd7, thereby enhancing Wnt signalling...
  91. Désert R, Mebarki S, Desille M, Sicard M, Lavergne E, Renaud S, et al. "Fibrous nests" in human hepatocellular carcinoma express a Wnt-induced gene signature associated with poor clinical outcome. Int J Biochem Cell Biol. 2016;81:195-207 pubmed publisher
    ..the myofibroblast marker ACTA2, the basement membrane components COL4A1 and LAMC1, the Wnt pathway members FZD1; FZD7; WNT2; LEF1; DKK1 and the Secreted Frizzled Related Proteins (SFRPs) 1; 2 and 5...
  92. Mazzotta S, Neves C, Bonner R, Bernardo A, Docherty K, Hoppler S. Distinctive Roles of Canonical and Noncanonical Wnt Signaling in Human Embryonic Cardiomyocyte Development. Stem Cell Reports. 2016;7:764-776 pubmed publisher
    ..Our analysis suggests that WNT3 and WNT8A, via FZD7 and canonical signaling, regulate BRACHYURY expression and mesoderm induction; that WNT5A/5B, via ROR2 and ..