FZD5

Summary

Gene Symbol: FZD5
Description: frizzled class receptor 5
Alias: C2orf31, HFZ5, frizzled-5, Wnt receptor, frizzled 5, seven transmembrane spanning receptor, frizzled family receptor 5, fz-5, fzE5, seven-transmembrane receptor frizzled-5
Species: human
Products:     FZD5

Top Publications

  1. Blumenthal A, Ehlers S, Lauber J, Buer J, Lange C, Goldmann T, et al. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood. 2006;108:965-73 pubmed
    ..We show that human peripheral-blood mononuclear cells express the WNT5A receptor Frizzled-5 (FZD5)...
  2. Magdesian M, Carvalho M, Mendes F, Saraiva L, Juliano M, Juliano L, et al. Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J Biol Chem. 2008;283:9359-68 pubmed publisher
    ..Furthermore, they suggest that blocking the interaction of Abeta with Fz might lead to novel therapeutic approaches to prevent neuronal dysfunction in Alzheimer disease. ..
  3. Tauriello D, Haegebarth A, Kuper I, Edelmann M, Henraat M, Canninga Van Dijk M, et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 2010;37:607-19 pubmed publisher
    ..Together, our results argue that loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt responses...
  4. Kushwaha P, Khedgikar V, Gautam J, Dixit P, Chillara R, Verma A, et al. A novel therapeutic approach with Caviunin-based isoflavonoid that en routes bone marrow cells to bone formation via BMP2/Wnt-β-catenin signaling. Cell Death Dis. 2014;5:e1422 pubmed publisher
    ..Owing to CAFG's inherent properties for bone, it could be positioned as a potential drug, food supplement, for postmenopausal osteoporosis and fracture repair. ..
  5. Liu J, Li H, Zheng B, Sun L, Yuan Y, Xing C. Competitive Endogenous RNA (ceRNA) Regulation Network of lncRNA-miRNA-mRNA in Colorectal Carcinogenesis. Dig Dis Sci. 2019;: pubmed publisher
    ..enriched in biological process including organic anion transport, collagen catabolic process, wound healing, Wnt receptor signalling and in pathways of tyrosine metabolism, taurine and hypotaurine metabolism, melanogenesis and ..
  6. Moody L, Kougias D, Jung P, Digan I, Hong A, Gorski A, et al. Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation. J Nutr Biochem. 2018;65:15-25 pubmed publisher
    ..Compared to C-0 females, HF-0 females also had higher expression of the adipogenesis gene Wnt receptor, frizzled 1 (Fzd1) and the triglyceride cleaving enzyme lipoprotein lipase (Lpl)...
  7. Lina T, Luo T, Velayutham T, Das S, McBride J. Ehrlichia Activation of Wnt-PI3K-mTOR Signaling Inhibits Autolysosome Generation and Autophagic Destruction by the Mononuclear Phagocyte. Infect Immun. 2017;85: pubmed publisher
    ..An inhibitor specific for the Wnt receptor signaling component Dishevelled induced lysosomal fusion with ehrlichial inclusions corresponding to p62 ..
  8. Kato K, Bhattaram P, Penzo Méndez A, Gadi A, Lefebvre V. SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res. 2015;30:1560-71 pubmed publisher
    ..plate formation, and in chondrocytes and perichondrocytes for expression of Fzd3 and Csnk1e, which encode a WNT receptor and casein kinase-1 subunit mediating planar cell polarity, respectively...
  9. Romanos G. Biomolecular Cell-Signaling Mechanisms and Dental Implants: A Review on the Regulatory Molecular Biologic Patterns Under Functional and Immediate Loading. Int J Oral Maxillofac Implants. 2016;31:939-51 pubmed publisher
    ..such as the expression of sclerostin as a negative regulator of bone formation (due to deactivation of the Wnt receptor) and downregulation of sclerostin under loading conditions, also present new understanding of the cellular and ..

More Information

Publications125 found, 100 shown here

  1. Wang Z, Zhang C, Cai J, Li Q, Wang Z, Jiang T. Integrated analysis of genome-wide DNA methylation, gene expression and protein expression profiles in molecular subtypes of WHO II-IV gliomas. J Exp Clin Cancer Res. 2015;34:127 pubmed publisher
    ..as novel glioma biomarkers: 977 up-regulated genes and 114 down-regulated genes, who involved in cell cycle, Wnt receptor signaling pathway and fatty acid metabolic process...
  2. Singh P, Ochoa Allemant P, Brown J, Perides G, Freedman S, Martin C. Effect of polyunsaturated fatty acids on postnatal ileum development using the fat-1 transgenic mouse model. Pediatr Res. 2019;85:556-565 pubmed publisher
    ..05), markers of the innate immune response. There was a >two-fold increased expression of Fzd5 and EphB2, markers of cell differentiation (p < 0...
  3. Zang S, Liu N, Wang H, Wald D, Shao N, Zhang J, et al. Wnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation. BMC Cancer. 2014;14:886 pubmed publisher
    ..non-canonical Wnt/Ca2+ pathway were detected in bone marrow samples from AML patients, and the expression of FZD4, FZD5, Wnt5a and RHOU were significantly reduced in newly diagnosed AML samples compared with normal controls...
  4. Pandey P, Bhardwaj A, Babu K. Regulation of WNT Signaling at the Neuromuscular Junction by the Immunoglobulin Superfamily Protein RIG-3 in Caenorhabditis elegans. Genetics. 2017;206:1521-1534 pubmed publisher
    ..that presynaptic RIG-3 functions by directly interacting with the immunoglobulin domain of the nonconventional Wnt receptor, ROR receptor tyrosine kinase (RTK), CAM-1, which functions in postsynaptic body-wall muscles...
  5. Ahmad S, Bhattacharyya P, Jeffries N, Gisselbrecht S, Michelson A. Two Forkhead transcription factors regulate cardiac progenitor specification by controlling the expression of receptors of the fibroblast growth factor and Wnt signaling pathways. Development. 2016;143:306-17 pubmed publisher
    ..is mediated by the Forkhead TFs regulating the fibroblast growth factor receptor Heartless (Htl) and the Wnt receptor Frizzled (Fz): CHES-1-like and jumu exhibit synergistic genetic interactions with htl and fz in CM ..
  6. Hii H, Liao M, Chen S, Wu C, Shih C. Distinct Patterns of Wnt3a and Wnt5a Signaling Pathway in the Lung from Rats with Endotoxic Shock. PLoS ONE. 2015;10:e0134492 pubmed publisher
    ..In contrast, the expressions of Wnt5a, Fzd5, and CaMKII were up-regulated in the lung of endotoxemic rats...
  7. Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, et al. Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways. PLoS ONE. 2014;9:e104937 pubmed publisher
    ..In conclusion, hrWnt7a enhances the synthesis of synapse and facilitates neuronal differentiation in hMSCS through various Frz receptors. These mechanisms may be employed widely in the transdifferentiation of other adult stem cells. ..
  8. Schutz L, Hurst R, Schreiber N, Spicer L. Transcriptome profiling of bovine ovarian theca cells treated with fibroblast growth factor 9. Domest Anim Endocrinol. 2018;63:48-58 pubmed publisher
    ..biological functions and unveiled interesting relationships among genes related to cell proliferation (eg, CCND1, FZD5, and MYB), antioxidation/cytoprotection (eg, HMOX1 and NQO1), and steroidogenesis (eg, CYP11A1 and STAR)...
  9. Anvarian Z, Mykytyn K, Mukhopadhyay S, Pedersen L, Christensen S. Cellular signalling by primary cilia in development, organ function and disease. Nat Rev Nephrol. 2019;15:199-219 pubmed publisher
  10. Hughes K, Sablitzky F, Mahida Y. Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Inflamm Bowel Dis. 2011;17:213-20 pubmed publisher
    ..By contrast, all the crypt epithelial preparations expressed Fzd1, Fzd5, Fzd7, Fzd8, and LRP6...
  11. Jansen E, Martens G. Novel insights into V-ATPase functioning: distinct roles for its accessory subunits ATP6AP1/Ac45 and ATP6AP2/(pro) renin receptor. Curr Protein Pept Sci. 2012;13:124-33 pubmed
    ..system that also regulates V-ATPase activity; (ii) acting as an adapter by binding to both the V-ATPase and the Wnt receptor complex, thereby recruiting the receptor complex into an acidic microenvironment...
  12. Insley P, Shaham S. Automated C. elegans embryo alignments reveal brain neuropil position invariance despite lax cell body placement. PLoS ONE. 2018;13:e0194861 pubmed publisher
    ..Our results demonstrate the utility of automated spatiotemporal alignments of C. elegans embryos, and uncover key principles guiding nervous-system development in this animal. ..
  13. Song J, Gao L, Yang G, Tang S, Xie H, Wang Y, et al. MiR-199a regulates cell proliferation and survival by targeting FZD7. PLoS ONE. 2014;9:e110074 pubmed publisher
    ..Furthermore, Frizzled type 7 receptor (FZD7), the most important Wnt receptor involved in cancer development and progression, was identified as a functional target of miR-199a...
  14. Luo T, Dunphy P, Lina T, McBride J. Ehrlichia chaffeensis Exploits Canonical and Noncanonical Host Wnt Signaling Pathways To Stimulate Phagocytosis and Promote Intracellular Survival. Infect Immun. 2015;84:686-700 pubmed publisher
    ..of TRP120-interacting Wnt pathway components/regulators and other critical components, such as Wnt5a ligand, Frizzled 5 receptor, β-catenin, nuclear factor of activated T cells (NFAT), and major signaling molecules, resulted in ..
  15. Podleschny M, Grund A, Berger H, Rollwitz E, Borchers A. A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration. PLoS ONE. 2015;10:e0145169 pubmed publisher
    ..Thus, our data suggest that Ror2 can substitute for PTK7 and that the signaling function of its kinase domain is required for this effect. ..
  16. Le L, Swingler T, Crowe N, Vincent T, Barter M, Donell S, et al. The microRNA-29 family in cartilage homeostasis and osteoarthritis. J Mol Med (Berl). 2016;94:583-96 pubmed publisher
    ..Expression profiles revealed regulation of new WNT-related genes. Amongst these, FZD3, FZD5, DVL3, FRAT2, and CK2A2 were validated as direct targets of the miR-29 family...
  17. Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, et al. WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol. 2015;15:173 pubmed publisher
    ..Non-canonical WNT pathway elements represented by FZD5, WNT5A and NFATc1 were remarkably elevated in colitis IELs...
  18. Ren Z, van Andel H, de Lau W, Hartholt R, Maurice M, Clevers H, et al. Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins. Blood. 2018;131:982-994 pubmed publisher
    ..HS side chains of syndecan-1 and that this binding contributes to paracrine Wnt pathway activation through the Wnt receptor Frizzled (Fzd)...
  19. Birdsey G, Shah A, Dufton N, Reynolds L, Osuna Almagro L, Yang Y, et al. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. Dev Cell. 2015;32:82-96 pubmed publisher
    ..Wnt/β-catenin pathway by promoting β-catenin stability, through signals mediated by VE-cadherin and the Wnt receptor Frizzled-4...
  20. Bause M, van der Horst R, Rentzsch F. Glypican1/2/4/6 and sulfated glycosaminoglycans regulate the patterning of the primary body axis in the cnidarian Nematostella vectensis. Dev Biol. 2016;414:108-20 pubmed publisher
    ..aboral marker genes and a reduction of oral markers at gastrula stage, strikingly similar to knockdown of the Wnt receptor NvFrizzled5/8...
  21. Guo J, Cagatay T, Zhou G, Chan C, Blythe S, Suyama K, et al. Mutations in the human naked cuticle homolog NKD1 found in colorectal cancer alter Wnt/Dvl/beta-catenin signaling. PLoS ONE. 2009;4:e7982 pubmed publisher
    ..Nkd inhibits Wnt signaling by binding to the Dishevelled (Dsh/Dvl) family of scaffold proteins that link Wnt receptor activation to beta-catenin accumulation and TCF-dependent transcription, but human NKD genes have yet to be ..
  22. Nikaido M, Law E, Kelsh R. A systematic survey of expression and function of zebrafish frizzled genes. PLoS ONE. 2013;8:e54833 pubmed publisher
    ..of reduction of melanocytes, suggesting the important involvement of untested fzds or another type of Wnt receptor in this process...
  23. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, et al. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016;538:350-355 pubmed publisher
    ..Here we carried out CRISPR-Cas9-mediated genome-wide screens and identified the members of the Wnt receptor frizzled family (FZDs) as TcdB receptors...
  24. Sardi C, Luchini P, Emanuelli A, Giannoni A, Martini E, Manara L, et al. Three months of Western diet induces small intestinal mucosa alteration in TLR KO mice. Microsc Res Tech. 2017;80:563-569 pubmed publisher
    ..interesting change involved the expression of proliferative and differentiation markers of WNT signaling, Ki67 and FzD5. Mice deficient in TLR2, 4, and NOD2 have a significant reduction in the proliferative cell numbers but do not show ..
  25. Ramirez V, Ramos Fernández E, Henriquez J, Lorenzo A, Inestrosa N. Wnt-5a/Frizzled9 Receptor Signaling through the G?o-G?? Complex Regulates Dendritic Spine Formation. J Biol Chem. 2016;291:19092-107 pubmed publisher
    ..We report that FZD9 (Frizzled9), a Wnt receptor related to Williams syndrome, is localized in the postsynaptic region, where it interacts with Wnt-5a...
  26. Yoshioka S, King M, Ran S, Okuda H, Maclean J, McAsey M, et al. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Mol Cancer Res. 2012;10:469-82 pubmed publisher
    ..Cotransfection with WNT7A and FZD5 receptor further increased activity, and this effect was inhibited by cotransfection with SFRP2 or dominant ..
  27. McCrea P, Maher M, Gottardi C. Nuclear signaling from cadherin adhesion complexes. Curr Top Dev Biol. 2015;112:129-96 pubmed publisher
    ..g., Wnt, receptor tyrosine kinase, Hippo, NFκB, and JAK/STAT), enabling cell-cell contacts to touch upon multiple biological outcomes in embryonic development and tissue homeostasis. ..
  28. Park S, Cui J, Yu W, Wu L, Carmon K, Liu Q. Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling. J Biol Chem. 2018;293:9759-9769 pubmed publisher
    ..i>ex vivo, and stimulated intestinal crypt growth in vivo Mechanistically, RSPO2 could increase Wnt receptor levels in the absence of any LGR without affecting ZNRF3 endocytosis and stability...
  29. Sagar -, Pröls F, Wiegreffe C, Scaal M. Communication between distant epithelial cells by filopodia-like protrusions during embryonic development. Development. 2015;142:665-71 pubmed publisher
    ..Taken together, our data suggest a role of filopodia-like protrusions in mediating signaling events between distant epithelial cells during embryonic development. ..
  30. Ozeki N, Yamaguchi H, Hase N, Hiyama T, Kawai R, Kondo A, et al. Polyphosphate-induced matrix metalloproteinase-3-mediated proliferation in rat dental pulp fibroblast-like cells is mediated by a Wnt5 signaling cascade. Biosci Trends. 2015;9:160-8 pubmed publisher
    ..Poly(P) also increased mRNA and protein levels of Wnt5 and the Wnt receptor Lrp5/Fzd9...
  31. Naspi A, Zingariello M, Sancillo L, Panasiti V, Polinari D, Martella M, et al. IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. Mol Carcinog. 2017;56:681-693 pubmed publisher
    ..As a consequence, the β-catenin destruction complex dissociates from the LRP6 Wnt receptor and GSK-3β is activated through dephosphorylation, becoming free to target cytoplasmic β-catenin which is ..
  32. Modzelewska K, Lauritzen A, Hasenoeder S, Brown L, Georgiou J, Moghal N. Neurons refine the Caenorhabditis elegans body plan by directing axial patterning by Wnts. PLoS Biol. 2013;11:e1001465 pubmed publisher
    ..modulate the location and strength of Wnt signaling along the anterior-posterior axis by employing a Ror family Wnt receptor to bind posteriorly derived Wnts, and hence, refine their distributions...
  33. Gerlach J, Jordens I, Tauriello D, van t Land Kuper I, Bugter J, Noordstra I, et al. TMEM59 potentiates Wnt signaling by promoting signalosome formation. Proc Natl Acad Sci U S A. 2018;115:E3996-E4005 pubmed publisher
    ..Here, we use internally tagged Wnt3a proteins to isolate and characterize activated, endogenous Wnt receptor complexes by mass spectrometry-based proteomics...
  34. Degirmenci B, Hausmann G, Valenta T, Basler K. Wnt Ligands as a Part of the Stem Cell Niche in the Intestine and the Liver. Prog Mol Biol Transl Sci. 2018;153:1-19 pubmed publisher
    ..This chapter focuses on the role of Wnt ligands in the intestine and the liver during homeostasis and cancer. ..
  35. Bobbs A, Gellerman K, Hallas W, Joseph S, Yang C, Kurkewich J, et al. ARID3B Directly Regulates Ovarian Cancer Promoting Genes. PLoS ONE. 2015;10:e0131961 pubmed publisher
    ..ARID3B also binds to the promoter of Wnt5A and its receptor FZD5. FZD5 is highly expressed in ovarian cancer cell lines, and is upregulated by exogenous ARID3B...
  36. Johnson B, Ren S, Karaca G, Gomez I, Fligny C, Smith B, et al. Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6. J Am Soc Nephrol. 2017;28:1769-1782 pubmed publisher
    ..These effects required the WNT receptor LDL receptor-related protein 6 (LRP6)...
  37. Zacksenhaus E, Liu J, Jiang Z, Yao Y, Xia L, Shrestha M, et al. Transcription Factors in Breast Cancer-Lessons From Recent Genomic Analyses and Therapeutic Implications. Adv Protein Chem Struct Biol. 2017;107:223-273 pubmed publisher
    ..Here we review these diverse oncogenic alterations in TFs in BC and discuss implications for therapy. ..
  38. Janda C, Dang L, You C, Chang J, de Lau W, Zhong Z, et al. Surrogate Wnt agonists that phenocopy canonical Wnt and ?-catenin signalling. Nature. 2017;545:234-237 pubmed publisher
    ..and differentiation and the self-renewal of stem cells by inducing ?-catenin-dependent signalling through the Wnt receptor frizzled (FZD) and the co-receptors LRP5 and LRP6 to regulate cell fate decisions and the growth and repair of ..
  39. Levy Strumpf N, Krizus M, Zheng H, Brown L, Culotti J. The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. PLoS Genet. 2015;11:e1005446 pubmed publisher
    ..a genetic approach combined with temporal gene expression analysis, we found a regulatory link between the Wnt receptor MOM-5/Frizzled and the UNC-6/Netrin receptor UNC-5...
  40. Guo L, Wang T, Wu Y, Yuan Z, Dong J, Li X, et al. WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway. Lab Invest. 2016;96:218-29 pubmed publisher
    ..The mRNA levels of WNT receptor FZD4 negatively correlated with the mRNA levels of IL-1β...
  41. Spanjer A, Baarsma H, Oostenbrink L, Jansen S, Kuipers C, Lindner M, et al. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8. FASEB J. 2016;30:1823-35 pubmed publisher
    ..A., Oostenbrink, L. M., Jansen, S. R., Kuipers, C. C., Lindner, M., Postma, D. S., Meurs, H., Heijink, I. H., Gosens, R., Königshoff, M. TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.
  42. Jiang X, Cong F. Novel Regulation of Wnt Signaling at the Proximal Membrane Level. Trends Biochem Sci. 2016;41:773-783 pubmed publisher
    ..crucial points in Wnt signaling, including post-translational modification of Wnt proteins, regulation of Wnt receptor degradation, internalization of Wnt receptor complex, and specific ligand-receptor complex formation...
  43. Jiang X, Cong F. Probing Wnt Receptor Turnover: A Critical Regulatory Point of Wnt Pathway. Methods Mol Biol. 2016;1481:39-48 pubmed publisher
    ..Many regulatory mechanisms exist to control proper signaling output. Recent studies suggest that cell surface Wnt receptor level is controlled by ubiquitination, and serve as a critical regulatory point of Wnt pathway activity as it ..
  44. Knútsdóttir H, Zmurchok C, Bhaskar D, Palsson E, Dalle Nogare D, Chitnis A, et al. Polarization and migration in the zebrafish posterior lateral line system. PLoS Comput Biol. 2017;13:e1005451 pubmed publisher
    ..We model mutually inhibitory FGF-Wnt signalling network in the PLLP and link tissue subdivision (Wnt receptor and FGF receptor activity domains) to receptor-ligand parameters...
  45. Skronska Wasek W, Gosens R, Konigshoff M, Baarsma H. WNT receptor signalling in lung physiology and pathology. Pharmacol Ther. 2018;187:150-166 pubmed publisher
  46. Ivatt R, Sanchez Martinez A, Godena V, Brown S, Ziviani E, Whitworth A. Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc Natl Acad Sci U S A. 2014;111:8494-9 pubmed publisher
    ..However, with the recent identification of SREBF1 as a risk locus for sporadic PD, our findings suggest a common mechanistic link between autosomal recessive and sporadic PD, and underscore the importance of mitochondrial homeostasis. ..
  47. Zebisch M, Jones E. Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3. J Struct Biol. 2015;191:149-55 pubmed publisher
    ..internalisation of the ternary LGR-Rspo-E3 complex removes the E3 ligase activity, which otherwise targets the Wnt receptor Frizzled for degradation, and thus enhances Wnt signalling...
  48. DeBruine Z, Xu H, Melcher K. Assembly and architecture of the Wnt/?-catenin signalosome at the membrane. Br J Pharmacol. 2017;174:4564-4574 pubmed publisher
    ..We present an emerging model, which unifies Wnt receptor oligomerization with intracellular signalosome formation, and then discuss how FZD receptors might be targeted ..
  49. Zhu Q, Lu G, Luo Z, Gui F, Wu J, Zhang D, et al. CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis. Biochem Biophys Res Commun. 2018;497:626-632 pubmed publisher
    ..In terms of mechanism, we found that circ_0067934 directly suppressed miR-1324, which targeted the 3'-UTR of FZD5 mRNA and subsequently downregulated the Wnt/β-catenin signaling pathway in HCC...
  50. Dai Y, Lu H, Wang S, Chang S, Li C, Huang Z, et al. MicroRNA-216b actively modulates diabetic angiopathy through inverse regulation on FZD5. Gene. 2018;658:129-135 pubmed publisher
    ..In MMEC(GK), putative miR-216b downstream target gene, frizzled class receptor 5 (FZD5), was evaluated by dual-luciferase reporter, qRT-PCR and western blot assays, respectively...
  51. Abdelhamed Z, Natarajan S, Wheway G, Inglehearn C, Toomes C, Johnson C, et al. The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. Dis Model Mech. 2015;8:527-41 pubmed publisher
    ..TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium...
  52. Schiffgens S, Wilkens L, Brandes A, Meier T, Franceschi E, Ermani M, et al. Sex-specific clinicopathological significance of novel (Frizzled-7) and established (MGMT, IDH1) biomarkers in glioblastoma. Oncotarget. 2016;7:55169-55180 pubmed publisher
    The Wnt receptor Frizzled-7 (FZD7) promotes tumor progression and can be currently targeted by monoclonal antibody therapy...
  53. Qiu X, Jiao J, Li Y, Tian T. Overexpression of FZD7 promotes glioma cell proliferation by upregulating TAZ. Oncotarget. 2016;7:85987-85999 pubmed publisher
    ..Frizzled-7 (FZD7) is a seven-pass trans-membrane Wnt receptor that plays a critical role in the development of various tumors...
  54. Horne L, Avilucea F, Jin H, Barrott J, Smith Fry K, Wang Y, et al. LRP5 Signaling in Osteosarcomagenesis: a Cautionary Tale of Translation from Cell Lines to Tumors. Transl Oncol. 2016;9:438-444 pubmed publisher
    ..Expression of this Wnt receptor correlated with metastatic disease and poor disease-free survival...
  55. Duñach M, Del Valle Pérez B, Garcia de Herreros A. p120-catenin in canonical Wnt signaling. Crit Rev Biochem Mol Biol. 2017;52:327-339 pubmed publisher
    ..involvement in four different steps: (i) the very early activation of CK1?, essential for Dvl-2 binding to the Wnt receptor complex; (ii) the internalization of GSK3 and Axin into multivesicular bodies, necessary for a complete ..
  56. Hao H, Jiang X, Cong F. Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer. Cancers (Basel). 2016;8: pubmed publisher
    ..In this review, we will discuss the biology of the R-spondin-ZNRF3/RNF43 signaling module, cancer-associated alterations of this signaling module, and their value as biomarkers to identify Wnt-addicted tumors. ..
  57. Zhang M, Muralimanoharan S, Wortman A, Mendelson C. Primate-specific miR-515 family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia. Proc Natl Acad Sci U S A. 2016;113:E7069-E7076 pubmed publisher
    ..to be critical for human SynT differentiation, including hCYP19A1/aromatase P450, glial cells missing 1 (GCM1), frizzled 5 (FZD5), WNT2, Sp1, and estrogen receptor-? (ER?) mRNA, were markedly up-regulated during SynT differentiation...
  58. Henry C, Llamosas E, Knipprath Meszaros A, Schoetzau A, Obermann E, Fuenfschilling M, et al. Targeting the ROR1 and ROR2 receptors in epithelial ovarian cancer inhibits cell migration and invasion. Oncotarget. 2015;6:40310-26 pubmed publisher
    ..Here we investigated the role of two Wnt receptor tyrosine kinases (RTKs), ROR1 and ROR2, and their putative ligand, Wnt5a, in ovarian cancer...
  59. Leonard J, Leonard D, Wolfe S, Liu J, Rivera J, Yang M, et al. The Dkk3 gene encodes a vital intracellular regulator of cell proliferation. PLoS ONE. 2017;12:e0181724 pubmed publisher
    ..One family member, DKK3, does not block Wnt receptor activation...
  60. Chang W, Choi S, Moon B, Cai M, Lyu J, Bai J, et al. Smek1/2 is a nuclear chaperone and cofactor for cleaved Wnt receptor Ryk, regulating cortical neurogenesis. Proc Natl Acad Sci U S A. 2017;114:E10717-E10725 pubmed publisher
    The receptor-like tyrosine kinase (Ryk), a Wnt receptor, is important for cell fate determination during corticogenesis. During neuronal differentiation, the Ryk intracellular domain (ICD) is cleaved...
  61. Saito Diaz K, Benchabane H, Tiwari A, Tian A, Li B, Thompson J, et al. APC Inhibits Ligand-Independent Wnt Signaling by the Clathrin Endocytic Pathway. Dev Cell. 2018;44:566-581.e8 pubmed publisher
    ..Unexpectedly, we find that blocking Wnt receptor activity in APC-deficient cells inhibits Wnt signaling independently of Wnt ligand...
  62. Hao H, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, et al. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012;485:195-200 pubmed publisher
    ..ZNRF3 is associated with the Wnt receptor complex, and inhibits Wnt signalling by promoting the turnover of frizzled and LRP6...
  63. Lu J, Zhang S, Nakano H, Simmons D, Wang S, Kong S, et al. A positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta. PLoS Biol. 2013;11:e1001536 pubmed publisher
    ..Employing global and trophoblast-specific Fzd5-null and Gcm1-deficient mouse models, combining trophoblast stem cell lines and tetraploid aggregation assay, we ..
  64. He X, Saint Jeannet J, Wang Y, Nathans J, Dawid I, Varmus H. A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science. 1997;275:1652-4 pubmed
    ..Wnt-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of the Frizzled family of seven-transmembrane receptors...
  65. Oishi I, Suzuki H, Onishi N, Takada R, Kani S, Ohkawara B, et al. The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells. 2003;8:645-54 pubmed
    ..Our findings indicate that Wnt5a and Ror2 interact physically and functionally. Ror2 may thus act as a receptor for Wnt5a to activate non-canonical Wnt signalling. ..
  66. Long Q, Du Y, Liu X, Li X, He D. miR-124 represses FZD5 to attenuate P-glycoprotein-mediated chemo-resistance in renal cell carcinoma. Tumour Biol. 2015;36:7017-26 pubmed publisher
    ..with their parental cells, miR-124 was downregulated in Caki-2/DOX and Caki-2/VBL cells, accompanied by increased FZD5 and P-gp. IC50 values were reduced significantly after miR-124 mimics were introduced into Caki-2/DOX cells...
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    ..These results indicate that FRP may function as an inhibitor of Wnt action during development and in the adult. ..