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Genomes and GenesSpecies | FUT3SummaryGene Symbol: FUT3 Description: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) Alias: CD174, FT3B, FucT-III, Les, Lewis FT, alpha-(1,3/1,4)-fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, fucosyltransferase III, galactoside 3(4)-L-fucosyltransferase Species: human Top Publications
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High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomasZahra Madjd
Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
Breast Cancer Res 7:R780-7. 2005..The SC101 mAb is a unique Lewisy/b binding antibody that binds to native and extended Lewisy and Lewisb haptens, displaying no cross reactivity with H type 1, H type 2, Lewisx or normal blood group antigens...
Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South AfricaH Pang
Department of Forensic Medicine, Kurume University School of Medicine, Fukuoka, Japan
Hum Genet 102:675-80. 1998Five novel missense mutations, viz., C304 A, T370 G, G484 A, G667 A, and G808 A, in the Lewis gene (FUT3) were detected in African (Xhosa) and Caucasian individuals in South Africa...- A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferaseJ F Kukowska-Latallo
Howard Hughes Medical Institute, Ann Arbor, Michigan
Genes Dev 4:1288-303. 1990.... - Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levelsT F Orntoft
Department of Clinical Biochemistry, Skejby University Hospital, DK 8200 Aarhus N, Denmark
J Biol Chem 271:32260-8. 1996..The Lewis gene, FUT3, encodes the only known alpha1-4-fucosyltransferase (FucT), and individuals who are deficient in this enzyme type .. 
Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesisThomas M Moehler
Department of Medicine V, University of Heidelberg, Heidelberg, Germany
J Cell Physiol 215:27-36. 2008..We investigated whether cell surface expression of the carbohydrate blood group determinant Lewis(y) (CD174) and its precursor structure H2 (CD173) on endothelial cells is influenced by soluble factors of tumor cells...- Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoformsH S Cameron
Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
J Biol Chem 270:20112-22. 1995The human alpha(1,3)-fucosyltransferase genes FUT3, FUT5, and FUT6 form a cluster on chromosome 19p13.3. Expression was studied using reverse transcriptase-polymerase chain reaction, rapid amplification of cDNA ends, and Northern analyses... - Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytesMarloes A Naarding
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Clin Invest 115:3256-64. 2005..The presence of such a DC-SIGN-binding molecule in human milk may both influence antigenic presentation and interfere with pathogen transfer in breastfed infants... - Signal transduction in esophageal and LES circular muscle contractionK M Harnett
Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
Yale J Biol Med 72:153-68. 1999..In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic M3 receptors, linked to .. - Typing for the human lewis blood group system by quantitative fluorescence-activated flow cytometry: large differences in antigen presentation on erythrocytes between A(1), A(2), B, O phenotypesG Larson
Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
Vox Sang 77:227-36. 1999..Now genomic typing of the Lewis gene is available. Additionally, flow cytometry has been used for typing. We wanted to compare the results of Lewis typing in healthy individuals using the three methods... - Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genesKristina Nyström
Department of Virology, University of Gothenburg, Gothenburg, Sweden
Glycobiology 19:847-59. 2009..after transcriptional activation of different combinations of dormant human fucosyltransferase genes (FUT1, FUT3, FUT5, and FUT6), whose gene products are responsible for the synthesis of Le antigens... - Mechanisms of GII.4 norovirus persistence in human populationsLisa C Lindesmith
University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
PLoS Med 5:e31. 2008..4 strains is common in human populations. In this article, we analyze molecular mechanisms governing GII.4 epidemiology, susceptibility, and persistence in human populations... - "Les maladies héréditaires:" 18th century disputes in FranceC López-Beltrán
Instituto de Investigaciones Filosóficas, Ciudad Universitaria, Mexico
Rev Hist Sci Paris 48:307-50. 1995..These developments turned out to be crucial for the emergence and strength of 19th century French (and European) hereditarianism, in medicine and other fields... - Biosynthesis and expression of the Sda and sialyl Lewis x antigens in normal and cancer colonNadia Malagolini
Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
Glycobiology 17:688-97. 2007.... - Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residueS Nishihara
Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan
FEBS Lett 462:289-94. 1999..fucosylated the distal GlcNAc residue of the polylactosamine chain while the other four alpha1,3FUT members, FUT3, FUT4, FUT5 and FUT6, preferentially fucosylated the inner GlcNAc residue... - FUT4 and FUT9 genes are expressed early in human embryogenesisA Cailleau-Thomas
U 504 INSERM, Universite de Paris Sud XI, 94807 Villejuif, France
Glycobiology 10:789-802. 2000..b>FUT3, FUT5, FUT6, and FUT7 were not detected by Northern blot... - Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesionXiaoyan Yin
Department of Biomedical Engineering, Cornell University, 205 Weill Hall, Ithaca, NY 14853, USA
Carbohydr Res 345:2334-42. 2010..RT-PCR, we demonstrated that FUT4 and FUT7 are the predominant FUTs expressed in hematopoietic cell line, while FUT3 is heavily expressed by multiple cancer cell lines including the prostate cancer cell line MDA PCa2b... - Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21R S McCurley
Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
Genomics 26:142-6. 1995..We have established physical maps of the FUT3-6 loci to study regulation of this gene family... - [Clinical evaluation of lung abscess diagnosed by transtracheal aspiration]M Konishi
Second Department of Internal Medicine, Nara Medical University
Kansenshogaku Zasshi 72:1193-6. 1998..A temperature higher than 38 degrees C was present in 12 patients but temperature les than 37 degrees C in 2. Multiple microorganisms were cultured from TTA in 15 patients. A mean of 2... - Structure-function analysis of human alpha 1-->3fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Ser178 in FucT-IVE H Holmes
Pacific Northwest Research Foundation, Seattle, Washington 98122, USA
J Biol Chem 270:8145-51. 1995..These results support the importance of Ser178 of FucT-IV in donor substrate binding and strongly suggest analogous Cys residues are the GDP-fucose protectable, N-ethylmaleimide-sensitive sites present in FucT-III and -V... - Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptorJ Yang
Center for Hemostasis and Thrombosis Research, Division of Hematology Oncology, New England Medical Center, Boston, MA, USA
Blood 87:4176-86. 1996..PSGL-1 on mouse myeloid cells is critical for high-affinity binding to P-selectin but not E-selectin... - Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substratesAmira Khaled
Glycochimie Moléculaire et Macromoléculaire, Laboratoire de Chimie Organique Multifonctionnelle, UMR 8182, Institut de Chimie Moleculaire et des Materiaux d Orsay, Batiment 420, Univ Paris Sud, F 91405 Orsay, France
Carbohydr Res 343:167-78. 2008..The surrogate of UDP-GlcNAc that was already known as its protected acetylated derivative, tested as N-acetylglucosamine donor with LgtA in the presence of Mn(2+) turned out not to be active either... - Complete genomic organization of futb encoding a bovine alpha 3-fucosyltransferase: exons in human orthologous genes emerged from ancestral intronic sequencesA Wierinckx
Unité de Génétique Moléculaire Animale Université INRA, Universite de Limoges, France
Mol Biol Evol 16:1535-47. 1999..A short sequence of the latter is homologous to distinct 5'-UT exons of FUT6 (alpha 3-fucosylation) and FUT3 (alpha 4-fucosylation), two human genes whose coding sequences are homologous to coding exon e of futb... - Synthesis of unnatural sugar nucleotides and their evaluation as donor substrates in glycosyltransferase-catalyzed reactionsAmira Khaled
Laboratoire de Chimie Organique Multifonctionnelle, UMR 8614, GDR 2590, Institut de Chimie Moléculaire et des Matériaux d Orsay ICMMO, Universite Paris Sud, Bat 420, F 91405 Orsay, France
Carbohydr Res 339:2641-9. 2004..1% efficiency as compared with UDP-GlcNAc, the natural donor substrate... - Histo-blood group antigen and human milk oligosaccharides: genetic polymorphism and risk of infectious diseasesJacques Le Pendu
INSERM U419, Institut de Biologie, 9 quai Moncousu, F 44093, Nantes, France
Adv Exp Med Biol 554:135-43. 2004..Their biosynthesis largely is controlled by the enzyme products of alleles at the ABO, FUT2 and FUT3 loci. We have shown that Norwalk virus (NV) uses structures based on H type 1 as its primary receptor... - [Identification of the hemolytic transfusion reaction caused by lewis antibody using serological and molecular biological methods]Xiao zhen Hong
Institute of Transfusion Medicine, Ministry of Health, Hangzhou, 310006, Zhejiang Province, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1192-5. 2008..phenotype was identified by using anti-Le(a) and anti-Le(b) blood grouping reagents and the entire coding region of FUT3 gene was amplified by PCR and sequenced directly... - Lewis(y) antigen (CD174) and apoptosis in gastric and colorectal carcinomas: correlations with clinical and prognostic parametersS E Baldus
Intitute of Pathology, University of Duesseldorf, Duesseldorf, Germany
Histol Histopathol 21:503-10. 2006Lewis(y) (Le(y)), also designated CD174, represents a carbohydrate blood group antigen which is strongly expressed in neoplastic gastrointestinal tissues. Previous reports indicated an association between Le(y) expression and apoptosis... - Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3-FUT5-FUT6 clusterA Oulmouden
Institut de Biotechnologie, Faculte des Sciences, Universite de Limoges, 87060 Limoges, France
J Biol Chem 272:8764-73. 1997Only one bovine gene, corresponding to the human cluster of genes FUT3-FUT5-FUT6, was found by Southern blot analysis. The cognate bovine alpha(1,3)-fucosyltransferase shares 67.3, 69.0, and 69... - Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferasesPeng Guo
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
FEBS Lett 562:93-8. 2004..However, it did not cause the increase of SLe(x) synthesis. Transfection of antisense GnTV into H7721 cells showed entirely opposite effects on the expression of above-mentioned SLe(x) and glycosyltransferases as the sense GnTV... - Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expressionRickard Nordén
Department of Virology, University of Gothenburg, Guldhedsgatan 10B, Goteborg, Sweden
Arch Virol 155:305-13. 2010..Lewis X in infected cells by activating transcription of three normally silent host glycosyltransferase genes, FUT3, FUT5, and FUT6, a process that is initiated by binding of viral RNA to cellular protein kinase R... - Development and application of a high resolution liquid chromatographic method for the analysis of complex pigment distributionsR L Airs
Department of Chemistry, University of York, Heslington, UK
J Chromatogr A 917:167-77. 2001..significantly more pigment components in extracts from a sediment (Priest Pot, Cumbria, UK), a microbial mat (les Salines de la Trinital, South Catalonia, Spain) and a culture (C... - Substrate and donor specificity of glycosyl transferasesB Ernst
University of Basel, Institute of Molecular Pharmacy, Switzerland
Glycoconj J 16:161-70. 1999..A survey of the involved enzymes: beta(1-3) and beta(1-4)galactosyl transferases, alpha(2-3)sialyl transferase, FucT III and FucT VI reveals that the enzymatic synthesis is highly efficient for the rapid preparation of sialyl Lewis(x)-.. - Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylationJacinta Serpa
Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
Cancer Lett 242:191-7. 2006..intestinal metaplasia (IM) and gastric carcinoma (GC), and can be partly due to overexpression of the Lewis (FUT3) enzyme... - Effects of carbocisteine on sialyl-Lewis x expression in an airway carcinoma cell line stimulated with tumor necrosis factor-alphaYuji Ishibashi
Bionic Materials Technology Group, Biomaterials Center, National Institute for Materials Science, 305 0044 Ibaraki, Japan
Eur J Pharmacol 530:223-8. 2006..100 mug/ml of carbocisteine was able to inhibit the TNF-alpha-induced expression of hST3GallV mRNA, FUT3 mRNA, C2/4GnT mRNA and sialyl-Lewis x epitopes as well as the TNF-alpha-induced activity of PI-PLC in NCI-H292 .. - Enzymatic synthesis of lacto-N-difucohexaose I which binds to Helicobacter pyloriTatsuo Miyazaki
Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Akiha ku, Niigata, Japan
Methods Enzymol 480:511-24. 2010..The obtained pentasaccharide was subsequently incubated with GDP-beta-l-fucose and commercial fucosyltransferase III (FUT3) to attach l-fucose to the d-GlcNAc residue of LNT with an alpha-1,4-linkage... - Promoter analysis of the human alpha1,3/4-fucosyltransferase gene (FUT III)Anna Dabrowska
Department of Immunochemistry, Institute of Immunology and Experimental Therapy, Polish Academy of Science, Weigla Str 12, 53 114 Wrocław, Poland
Biochim Biophys Acta 1731:66-73. 2005alpha1,3/4-Fucosyltransferase (FUT3) is involved in the synthesis of sialyl Le(a) tetrasaccharide, a tumor-associated carbohydrate antigen... - Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II βChangzhi Wang
Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, People s Republic of China
Anat Rec (Hoboken) 294:961-9. 2011..Therefore, the inhibition of Lewis (y) antigen may be a novel strategy of cancer chemotherapy... - Lewis blood genotypes of peptic ulcer and gastric cancer patients in TaiwanChi Jung Yei
Blood Bank, and Division of Hematology Oncology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Shih Chuan 1st Road, Kaohsiung, Taiwan, China
World J Gastroenterol 11:4891-4. 2005..Therefore, we investigated the relationship between Le and Se genotypes and H pylori infection rates in people with peptic ulcer or gastric cancer... - Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cellsMercè Padró
Programa de Recerca en Càncer, IMIM Hospital del Mar, 08003 Barcelona, Spain
Glycoconj J 28:99-110. 2011..IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5. In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected... - Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cellsWei Ming Lin
Laboratory of Molecular and Experimental Pathology, Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, China
Virchows Arch 456:403-9. 2010Histo-blood group antigens CD173 (H2) and CD174 (Lewis Y) are known to be developmentally regulated carbohydrate antigens which are expressed to a varying degree on many human carcinomas... - Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa proteinKoji Higai
Department of Clinical Chemistry, School of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
Biochim Biophys Acta 1760:1355-63. 2006.... - Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumabHoward M Stern
Departments of Research Pathology, Development Oncology Diagnostics, and Molecular Oncology, Genentech, Inc, South San Francisco, California, USA
Clin Cancer Res 16:1587-96. 2010..of the O-glycosylation enzymes GALNT14 in non-small cell lung cancer (NSCLC) cell lines (among others) and of FUT3/6 in colorectal cancer (CRC) cell lines... - Core saccharide dependence of sialyl Lewis X biosynthesisJonas Löfling
Division of Clinical Immunology and Transfusion Medicine, F79, Karolinska Institute, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
Glycoconj J 26:33-40. 2009..Our results define the specificities of FucT-III-VII in SLe(x) biosynthesis on O-glycans with different core structures and the fine specificity of the widely used anti-SLe(x) monoclonal antibody, KM93... - Human noroviruses recognize sialyl Lewis x neoglycoproteinGustaf E Rydell
Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
Glycobiology 19:309-20. 2009..using virus-like particles (VLPs) and saliva samples from 81 individuals genotyped for FUT2 (secretor) and FUT3 (Lewis) and phenotyped for ABO and Lewis blood groups... - [alpha1,2-fucosyltransferase gene transfection influences on biological behavior of ovarian carcinoma-derived RMG-I cells]Ying Ying Hao
Department of Gynecology and Obstetrics, the Shengjing Hospital of China Medical University, Shenyang 110004, China
Fen Zi Xi Bao Sheng Wu Xue Bao 41:435-42. 2008..These findings indicate that alpha1,2-FT and Lewis y antigen have the ability to enhance the proliferation and elevate the survival rates of RMG-I cells, which can promote the genesis and development of ovarian carcinoma... - Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severityJENNIFER L TAYLOR-COUSAR
Pulmonary Division, Internal Medicine and Pediatrics, Albuquerque, New Mexico, University of New Mexico Health Sciences Center, United States of America
PLoS ONE 4:e4270. 2009.... - Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cellsRickard Nordén
Department of Virology, University of Gothenburg, Gothenburg, Sweden
Glycobiology 19:776-88. 2009..unidentified host factors, eventually resulting in transcription of three dormant host fucosyltransferase genes (FUT3, FUT5, and FUT6), whose gene products are rate-limiting for synthesis of sLe(x)... - Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, AustriaEva Maria Matzhold
Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
Transfusion 49:2097-108. 2009Genes for fucosyltransferases 1 (FUT1:H), 2 (FUT2:Secretor), and 3 (FUT3:Lewis) encode enzymes crucial for ABH and Lewis blood group antigen synthesis. They are highly polymorphic and ethnically and geographically specific. - Gender differences in genetic risk profiles for cardiovascular diseaseKaisa Silander
Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
PLoS ONE 3:e3615. 2008..We aimed to estimate whether the genetic risk profiles of coronary heart disease (CHD), ischemic stroke and the composite end-point of CVD differ between the genders... - IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosaSophie Groux-Degroote
Unite de Glycobiologie Structurale et Fonctionnelle, UMR CNRS no 8576, Batiment C9, Universite des Sciences et Technologies de Lille, F 59655 Villeneuve d Ascq, Lille, France
Biochem J 410:213-23. 2008..a significant increase in the expression of alpha1,3/4-fucosyltransferases [FUT11 (fucosyltransferase 11 gene) and FUT3], alpha2-6- and alpha2,3-sialyltransferases [ST3GAL6 (alpha2,3-sialyltransferase 6 gene) and ST6GAL2 (alpha2,6-.. - Breast cancer humoral immune response: involvement of Lewis y through the detection of circulating immune complexes and association with Mucin 1 (MUC1)Marina Isla Larrain
Centre for Basic and Applied Immunological Research, Faculty of Medical Sciences, National University of La Plata, Buenos Aires, Argentina
J Exp Clin Cancer Res 28:121. 2009.... - Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring StudyLuc Djousse
Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
Am Heart J 153:636-9. 2007Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease. - Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cellsKristina Nyström
Department of Virology, University of Goteborg, Goteborg, Sweden
Glycobiology 17:355-66. 2007..Both viruses induced FUT3, FUT5, and FUT6, encoding alpha1,3- and/or alpha1,4-specific fucosyltransferases... - [FUT3 gene polymorphism associated with Lewis blood group in Chinese Zhejiang population]Xian guo Xu
Institute of Transfusion Medicine, Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou 310006, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:601-4. 2006To investigate the alpha-1, 3/4-fucosyltransferase gene (FUT3) polymorphism associated with Lewis blood group in Zhejiang population, the Lewis phenotypes of 183 random samples from Chinese blood donors in Zhejiang province were .. - Association of Lewis and Secretor gene polymorphisms and Helicobacter pylori seropositivity among Japanese-BraziliansSueli Mieko Oba-Shinjo
Department of Neurology, School of Medicine, University of Sao Paulo, Av Dr Arnaldo, 455, 4th Floor, Room 4110, Cerqueira Cesar, 01246 903, Sao Paulo, SP, Brazil
J Gastroenterol 39:717-23. 2004..The present work aims to investigate the associations between Se and Le gene polymorphisms and H. pylori infection among Japanese-Brazilians... - The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligandK L Koszdin
Ciba Geigy Corp, Summit, NJ 07901
Biochem Biophys Res Commun 187:152-7. 1992..The substrate specificity of the FucT-VI gene product suggests that FucT-VI may be an enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis x, in myeloid cells... - Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart studyV Salomaa
National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
J Intern Med 247:689-98. 2000..An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction... - Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sitesE H Holmes
Department of Cell Surface Biochemistry, Molecular Medicine, Northwest Hospital, Seattle, Washington 98134, USA
J Biol Chem 275:24237-45. 2000..Among the human FucTs is a subset of enzymes (FucT III, V, and VI) having highly homologous sequences, especially in the catalytic domain, and Cys residues in FucT III .. - Molecular analysis of secretor type alpha(1,2)-fucosyltransferase gene mutations in the Chinese and Thai populationsJ G Chang
Department of Medical Research and Pediatrics, China Medical College Hospital, Taichung, Taiwan
Transfusion 39:1013-7. 1999..of fucosyltransferase genes alpha(1,2)-fucosyltransferase (FUT2 or Se) and alpha(1,3/1,4)-fucosyltransferase (FUT3 or Le), are responsible for the polymorphism of Lewis blood group phenotypes... - Plasma alpha1,3-fucosyltransferase deficiency in schizophreniaS Yazawa
Japan Immunoresearch Laboratories, Takasaki, Japan
Exp Clin Immunogenet 16:125-30. 1999..Genotyping of the Le gene (FUT3) in these patients demonstrated that 2 of them were also FUT3 deficient and were grouped as Lewis- individuals .. - Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cellsB W Weston
The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
Cancer Res 59:2127-35. 1999..by stable transfection of antisense sequences directed at the human Lewis alpha(1,3/1,4)fucosyltransferase gene, FUT3. The metastatic parental cell line, HT-29LMM, expressed high levels of sialyl Lewis x, sialyl Lewis a, alpha(1,3/1,.. - Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell linesE Mas
INSERM U 260, Unité de Recherche de Physiopathologie des Régulations Hormono Nutritionnelles, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
Glycobiology 8:605-13. 1998..Transcripts of FUT1, FUT2, FUT3, FUT4, FUT5, and FUT7 were detected by RT-PCR in carcinoma cell lines as well as in normal and tumoral tissues... - Evolution of fucosyltransferase genes in vertebratesM Costache
INSERM U178, Universite de Paris Sud XI, 94807 Villejuif Cedex, France
J Biol Chem 272:29721-8. 1997Cloning and expression of chimpanzee FUT3, FUT5, and FUT6 genes confirmed the hypothesis that the gene duplications at the origin of the present human cluster of genes occurred between: (i) the great mammalian radiation 80 million years .. - Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIIIA Elmgren
Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
J Biol Chem 272:21994-8. 1997The Lewis alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII, encoded by the FUT3 gene is responsible for the final synthesis of Lea and Leb antigens... - A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoproteinE C Brinkman Van der Linden
Department of Medical Chemistry, Faculty of Medicine, Van der Boechorststraat 7, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
J Biol Chem 271:14492-5. 1996..in the liver, we studied the fucosylation of three glycoproteins in sera of individuals with or without inactivated FUT3 and/or FUT6 gene(s) but with a functional FUT5 gene... - Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individualsT Kudo
Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan
J Biol Chem 271:9830-7. 1996..The phylogenic aspect and biological significance of the Se and Le genes are discussed... - Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancersSylvain Julien
Breast Cancer Biology, King s College London, Guy s Hospital, London, United Kingdom
Cancer Res 71:7683-93. 2011..We found that genes involved in the synthesis of sialyl-Lewis x (sLe(x); FUT3, FUT4, and ST3GAL6) are significantly increased in estrogen receptor alpha-negative (ER-negative) tumors compared .. - Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individualsY Koda
Department of Legal Medicine, School of Medicine, Kurume University, Japan
Blood 82:2915-9. 1993..We isolated the protein-coding region of the Lewis FT cDNA from Le(+) and Le(-) gastric mucosa by polymerase chain reaction (PCR) amplification... - Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigreesR Mollicone
INSERM U 178, Villejuif, France
J Biol Chem 269:20987-94. 1994..They are synthesized by two fucosyltransferases, encoded by Lewis (FUT3) and secretor (FUT2) loci... - Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19S Nishihara
Division of Cell Biology, Soka University, Tokyo, Japan
Biochem Biophys Res Commun 190:42-6. 1993..These genes were present 13 kb apart in tandem orientation. The FucT-III gene has already been mapped on the Lewis locus of chromosome 19. This demonstrated that FucT-VI gene was localized close to the Lewis locus on chromosome 19... - Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19I Reguigne-Arnould
INSERM U 178, Villejuif, France
Cytogenet Cell Genet 71:158-62. 1995..7) and 9 cM proximal to D19S571 (lod score 11.7). Polymorphic markers of FUT3, FUT5, and FUT6 were used for linkage analysis with 14 Généthon microsatellites in Indonesian families... - Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificB W Weston
Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0650
J Biol Chem 267:4152-60. 1992..These results are consistent with the hypothesis that this gene encodes the human "plasma type" alpha(1,3)fucosyltransferase, and suggest a molecular basis for a family of human alpha(1,3)fucosyltransferase genes... - Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cellsS Schnyder-Candrian
Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Proc Natl Acad Sci U S A 97:8369-74. 2000..Storage of a fucosyltransferase in Weibel-Palade bodies suggests a function independent of Golgi-associated glycosylation... - A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopesN Ikeda
Department of Biochemistry and Department of Surgery, Osaka University Medical School, Suita, Osaka 565 0871, Japan
J Biol Chem 276:38588-94. 2001..The present remodeling system might be of potential use as a tool for the study of the physiological roles of 3'-sulfated Lewis epitopes, including interaction with selectins... - ABO blood type, Lewis and Secretor genotypes, and chronic atrophic gastritis: a cross-sectional study in JapanAtsuko Shibata
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA
Gastric Cancer 6:8-16. 2003..Such host factors as Le and Se genotypes and ABO blood type may affect the establishment of H. Pylori infection and, once infected, the risk of chronic atrophic gastritis... - Importance of Cys, Gln, and Tyr from the transmembrane domain of human alpha 3/4 fucosyltransferase III for its localization and sorting in the Golgi of baby hamster kidney cellsVictor L Sousa
Laboratory of Glycobiology, Instituto de Tecnologia Quimica e Biologica, Apartado 127, 2780 Oeiras, Portugal
J Biol Chem 278:7624-9. 2003Human fucosyltransferase III (EC ) (FT3wt) is localized in the Golgi of baby hamster kidney cells and synthesizes Lewis determinants associated with cell adhesion events... - Molecular genetic analysis of the human Lewis histo-blood group systemS Nishihara
Division of Cell Biology, Soka University, Tokyo, Japan
J Biol Chem 269:29271-8. 1994..The frequency of occurrence of Le, le1, and le2 in the Japanese population by random sampling study was found to be 66, 30, and 4%, respectively... - Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosidesAkiko Tsuchida
Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
J Biol Chem 278:22787-94. 2003..Therefore, it appears that ST6GalNAc V/VI and fucosyltransferase III (FUT-3) compete for sialyl Lc4, their common substrate... - Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) studyB Cakir
Department of Public Health, Faculty of Medicine, Hacettepe University, Ankara, Turkey
J Intern Med 255:40-51. 2004..Lewis genotyping included four major mutations of the Lewis (FUT3) gene at nucleotide positions 59, 1067, 202 and 314. - Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domainFabrice Dupuy
Unité de Génétique Moléculaire Animale, UMR 1061 Université INRA, GDR CNRS 2590, Institut des Sciences de la Vie et de la Santé, Faculte des Sciences et Techniques, 87060 Limoges, France
Glycobiology 14:347-56. 2004..FUT6 and FUTb enzymes, harboring R in the acceptor-binding motif, transfer fucose in alpha1,3 linkage, whereas FUT3 and FUT5 enzymes with W at the candidate position can also transfer fucose in alpha1,4 linkage-FUT3 being more .. - Effect of the manganese ion on human alpha3/4 fucosyltransferase III activityAngelina S Palma
Instituto de Tecnologia Quimica e Biologica, Oeiras, Portugal
Biometals 17:35-43. 2004..of manganese and other divalent cations on the activity of a soluble recombinant form of human alpha3/4 fucosyltransferase III (SFT3) expressed in Spodoptera frugiperda (Sf9) insect cells was studied... - Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samplesA Grahn
Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
Hum Mutat 18:358-9. 2001..reaction method using sequence-specific primers (PCR-SSP) for rapid and correct genotyping of the common Lewis (FUT3) gene mutations 59T>G, 202T>C, 314C>T, 508G>A, and 1067T>A... - [Belgian law on the Régime de l'alcool of 1919: from the individual measures to social well-being]R Campos
Departamento de Historia de la Ciencia, , CSIC
Cuad Complut Hist Med Cienc 2:275-94. 1993..The promulgation of "La loi sur le Régime de l'alcool" and "La loi concernant les débits des Boissons Fermentés" on August 29 1919 was the final step in this change in opinion... - Distribution of Lewis (FUT3)genotype and allele: frequencies in a biethnic United States populationB Cakir
Department of Public Health, Hacettepe University Faculty of Medicine, Ankara, Turkey
Ann Hematol 81:558-65. 2002..distribution of four major single nucleotide polymorphisms (SNPs) (T59G, T1067G, T202C, and C314T) of the Lewis ( FUT3)gene in a biethnic United States population... - Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibodyY Ikehara
Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
Cancer Epidemiol Biomarkers Prev 10:971-7. 2001..Immunohistochemical analysis supported the finding that Se and Le genotypes affected the expression of H. pylori adhesin ligands. We conclude that Se and Le genotypes affect susceptibility to H. pylori infection... - The Lewis blood group--a new genetic marker of obesityH O Hein
Epidemiological Research Unit, Clinic of Environmental and Occupational Medicine, Bispebjerg University Hospital, Copenhagen NV, Denmark
Int J Obes (Lond) 29:540-2. 2005..Identification of this new genetic marker of obesity may, for example, contribute to the explanation of individual and ethnic differences in the prevalence of obesity... - Genotypic heterogeneity among Lewis negative individualsA Elmgren
Department of Clinical Chemistry and Transfusion Medicine, Sahlgren s Hospital, Goteborg, Sweden
Biochem Biophys Res Commun 196:515-20. 1993We have identified a C to T mutation at nucleotide No 314 in the coding region of the human alpha (1,3/1,4) fucosyltransferase III (FT-III) gene held responsible for synthesis of Lewis a and b antigens... - Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese populationJacinta Serpa
IPATIMUP Institute of Pathology and Molecular Immunology of the University of Porto, University of Porto, Rua Dr Roberto Frias s n, 4200, Porto, Portugal
J Hum Genet 48:183-9. 2003The human alpha-1,3/4 fucosyltransferase III (FucT III) catalyses the synthesis of Lewis antigens including Le(b) antigen which is a ligand for Helicobacter pylori adhesion... - ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in TaiwanY L Chen
Laboratory of Molecular Diagnostics, Department of Clinical Pathology, Chi Mei Hospital, Tainan, Taiwan
Clin Exp Allergy 35:926-32. 2005.... - Alpha (1,3/1,4)fucosyltransferase (FucT-III) gene is inactivated by a single amino acid substitution in Lewis histo-blood type negative individualsS Nishihara
Division of Cell Biology, Soka University, Tokyo, Japan
Biochem Biophys Res Commun 196:624-31. 1993..This mutation, however, was not responsible for FucT-III gene inactivation... - Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotypeMalin Modin Larsson
Division of Molecular Virology, University of Linkoping, 581 85 Linkoping, Sweden
J Infect Dis 194:1422-7. 2006..Histo-blood group antigens and secretor status have been associated with susceptibility to Norovirus infections, which suggests that antibody prevalence and titer might correlate with these phenotypes... - Studies on mechanism of Sialy Lewis-X antigen in liver metastases of human colorectal carcinomaX W Li
Department of Pathology, Nanfang Hospital of the First Military Medical University, Tonghe, Guangzhou 510515, Guangdong Province, China
World J Gastroenterol 7:425-30. 2001 - Smoking and serum CA19-9 levels according to Lewis and secretor genotypesSayo Kawai
Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
Int J Cancer 123:2880-4. 2008..When hemoglobin A1c was further adjusted, the association became stronger (p = 0.0027). In addition to polymorphic variations, some components of cigarette smoke may influence the production or destruction of CA19-9... - Molecular behavior of mutant Lewis enzymes in vivoS Nishihara
Division of Cell Biology, Institute of Life Science, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 8577, Japan
Glycobiology 9:373-82. 1999..is determined by a Lewis type alpha(1,3/1, 4)-fucosyltransferase (Lewis enzyme) encoded by the Fuc-TIII gene ( FUT3 gene; Lewis gene)... - CD15 expression in human myeloid cell differentiation is regulated by sialidase activitySamah Zeineb Gadhoum
Department of Dermatology, Brigham and Women s Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
Nat Chem Biol 4:751-7. 2008..Our results unveil a new paradigm by demonstrating a critical role for post-Golgi membrane glycosidase activity in the 'biosynthesis' of a key glycan determinant... - Expression of ABH/Lewis-related antigens as prognostic factors in patients with breast cancerT Nakagoe
First Department of Surgery, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki, 852 8501 Japan
J Cancer Res Clin Oncol 128:257-64. 2002..The prognostic value of altered blood group factor and Lewis-related carbohydrate antigen expression in breast cancers has not been fully determined... - Is Sialyl Lewis x antigen expression a prognostic factor in patients with breast cancer?Prisca Sozzani
Department of Obstetrics and Gynecology, University of Turin, Turin, Italy
Int J Surg Pathol 16:365-74. 2008..Survival was similar for sLex-positive and sLex-negative tumors (62% vs 60%) for overall survival and for disease-free survival (59% vs 56%). Expression of sLex antigen in breast cancer is not associated with breast cancer survival... - Alteration of gibberellin response in transgenic tobacco plants which express a human Lewis fucosyltransferaseCaroline Joly
Glycobiologie Végétale et Biotechnologie EA3176, Institut des Sciences de la Vie et de la Santé, Universite de Limoges, 123 Avenue Albert Thomas, 87060 Limoges Cedex, France
Plant Physiol Biochem 42:629-37. 2004..Thus, alpha4-fucosylation could act as a possible modulator of conformation and/or functioning of N-glycoproteins involved in the gibberellin-dependent elongation process... - DNA sequencing and screening for point mutations in the human Lewis (FUT3) gene enables molecular genotyping of the human Lewis blood group systemA Elmgren
Department of Clinical Chemistry, Göteborg University Sahlgrenska Hospital, Sweden
Vox Sang 70:97-103. 1996..Of 21 Le(a-b+) and 4 Le(a+b-), 17 typed as LeLe and 7 as Lele202/314. A pedigree study of 8 Lewis-positive individuals showed that the mutations at nucleotides 202 and 314 were located on the same allele... - Genetic variation of FUT3 in Ghanaians, Caucasians, and MongoliansMikiko Soejima
Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume, Fukuoka, Japan
Transfusion 49:959-66. 2009The FUT3 gene regulates the expression of Lewis blood group antigens. Several lines of evidence suggest association between expression of these antigens and Helicobacter pylori infection or susceptibility to cardiovascular diseases...
Research Grants
- Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.Ardythe Morrow; Fiscal Year: 2009..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
- Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.Ardythe Morrow; Fiscal Year: 2009..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
- Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.Ardythe L Morrow; Fiscal Year: 2010..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
- Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma DetectionDavid E Misek; Fiscal Year: 2010..These early detection biomarkers may have the utility to facilitate early detection of this deadly malignancy. ..
- Role of sLeX-modified O-glycans in carcinoma metastasisCatherine St Hill; Fiscal Year: 2007..This K08 award will strengthen the candidate's knowledge of cancer biology and ultimately provide her with the mentoring, skills, and resources needed to achieve her goal to be an independent academic clinical scientist. ..
- Fatty Acids and Heart Failure in the Physicians' Health StudyLuc Djousse; Fiscal Year: 2010....
- Genetic Factors and Cardiovascular DiseaseLuc Djousse; Fiscal Year: 2005..Lastly, we will use data collected on participants of the GENCAC study to evaluate these genetic factors in relation to coronary calcification, a measure of coronary atherosclerosis. ..
- Genetic Modifiers in CF: Role of ABH polymorphismsJENNIFER TAYLOR COUSAR; Fiscal Year: 2006..1) Determine whether polymorphisms in genes in the ABH pathway (including ABO, FUT2 [Secretor status], and FUT3 [Lewis antigen]) segregate with "severe" or "mild" lung disease, or with CF pathogen colonization; (2) Determine ..
- EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTSBrent Weston; Fiscal Year: 2004..of these glycans on human colon cancer cells is largely controlled by the alpha(1,3)fucosyltransferases FUT3 and FUT6...
- Fatty Acids and Heart Failure in the Physicians' Health StudyLuc Djousse; Fiscal Year: 2009....