FUT3

Summary

Gene Symbol: FUT3
Description: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
Alias: CD174, FT3B, FucT-III, Les, Lewis FT, alpha-(1,3/1,4)-fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, fucosyltransferase III, galactoside 3(4)-L-fucosyltransferase
Species: human

Top Publications

  1. ncbi Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels
    T F Orntoft
    Department of Clinical Biochemistry, Skejby University Hospital, DK 8200 Aarhus N, Denmark
    J Biol Chem 271:32260-8. 1996
  2. ncbi Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specific
    B W Weston
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0650
    J Biol Chem 267:4152-60. 1992
  3. doi Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria
    Eva Maria Matzhold
    Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    Transfusion 49:2097-108. 2009
  4. ncbi Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa
    H Pang
    Department of Forensic Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Hum Genet 102:675-80. 1998
  5. doi Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis
    Thomas M Moehler
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 215:27-36. 2008
  6. pmc High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas
    Zahra Madjd
    Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
    Breast Cancer Res 7:R780-7. 2005
  7. ncbi A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase
    J F Kukowska-Latallo
    Howard Hughes Medical Institute, Ann Arbor, Michigan
    Genes Dev 4:1288-303. 1990
  8. pmc Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:3256-64. 2005
  9. ncbi Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
  10. pmc Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. ncbi Influence of Lewis alpha1-3/4-L-fucosyltransferase (FUT3) gene mutations on enzyme activity, erythrocyte phenotyping, and circulating tumor marker sialyl-Lewis a levels
    T F Orntoft
    Department of Clinical Biochemistry, Skejby University Hospital, DK 8200 Aarhus N, Denmark
    J Biol Chem 271:32260-8. 1996
    ..The Lewis gene, FUT3, encodes the only known alpha1-4-fucosyltransferase (FucT), and individuals who are deficient in this enzyme type ..
  2. ncbi Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specific
    B W Weston
    Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109 0650
    J Biol Chem 267:4152-60. 1992
    ..These results are consistent with the hypothesis that this gene encodes the human "plasma type" alpha(1,3)fucosyltransferase, and suggest a molecular basis for a family of human alpha(1,3)fucosyltransferase genes...
  3. doi Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria
    Eva Maria Matzhold
    Department of Blood Group Serology and Transfusion Medicine, Medical University of Graz, Graz, Austria
    Transfusion 49:2097-108. 2009
    Genes for fucosyltransferases 1 (FUT1:H), 2 (FUT2:Secretor), and 3 (FUT3:Lewis) encode enzymes crucial for ABH and Lewis blood group antigen synthesis. They are highly polymorphic and ethnically and geographically specific.
  4. ncbi Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa
    H Pang
    Department of Forensic Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Hum Genet 102:675-80. 1998
    Five novel missense mutations, viz., C304 A, T370 G, G484 A, G667 A, and G808 A, in the Lewis gene (FUT3) were detected in African (Xhosa) and Caucasian individuals in South Africa...
  5. doi Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis
    Thomas M Moehler
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 215:27-36. 2008
    ..We investigated whether cell surface expression of the carbohydrate blood group determinant Lewis(y) (CD174) and its precursor structure H2 (CD173) on endothelial cells is influenced by soluble factors of tumor cells...
  6. pmc High expression of Lewis y/b antigens is associated with decreased survival in lymph node negative breast carcinomas
    Zahra Madjd
    Academic Department of Clinical Oncology, Institute of Infections Immunity and Inflammation, University of Nottingham, City Hospital, Nottingham, UK
    Breast Cancer Res 7:R780-7. 2005
    ..The SC101 mAb is a unique Lewisy/b binding antibody that binds to native and extended Lewisy and Lewisb haptens, displaying no cross reactivity with H type 1, H type 2, Lewisx or normal blood group antigens...
  7. ncbi A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase
    J F Kukowska-Latallo
    Howard Hughes Medical Institute, Ann Arbor, Michigan
    Genes Dev 4:1288-303. 1990
    ....
  8. pmc Lewis X component in human milk binds DC-SIGN and inhibits HIV-1 transfer to CD4+ T lymphocytes
    Marloes A Naarding
    Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Clin Invest 115:3256-64. 2005
    ..The presence of such a DC-SIGN-binding molecule in human milk may both influence antigenic presentation and interfere with pathogen transfer in breastfed infants...
  9. ncbi Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms
    H S Cameron
    Department of Pediatrics, University of North Carolina at Chapel Hill 27599 7220, USA
    J Biol Chem 270:20112-22. 1995
    The human alpha(1,3)-fucosyltransferase genes FUT3, FUT5, and FUT6 form a cluster on chromosome 19p13.3. Expression was studied using reverse transcriptase-polymerase chain reaction, rapid amplification of cDNA ends, and Northern analyses...
  10. pmc Signal transduction in esophageal and LES circular muscle contraction
    K M Harnett
    Department of Medicine, Rhode Island Hospital and Brown University, Providence 02903, USA
    Yale J Biol Med 72:153-68. 1999
    ..In contrast, lower esophageal sphincter (LES) contraction induced by maximally effective doses of ACh is mediated by muscarinic M3 receptors, linked to ..
  11. ncbi Typing for the human lewis blood group system by quantitative fluorescence-activated flow cytometry: large differences in antigen presentation on erythrocytes between A(1), A(2), B, O phenotypes
    G Larson
    Department of Clinical Chemistry and Transfusion Medicine, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Vox Sang 77:227-36. 1999
    ..Now genomic typing of the Lewis gene is available. Additionally, flow cytometry has been used for typing. We wanted to compare the results of Lewis typing in healthy individuals using the three methods...
  12. doi Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes
    Kristina Nyström
    Department of Virology, University of Gothenburg, Gothenburg, Sweden
    Glycobiology 19:847-59. 2009
    ..after transcriptional activation of different combinations of dormant human fucosyltransferase genes (FUT1, FUT3, FUT5, and FUT6), whose gene products are responsible for the synthesis of Le antigens...
  13. pmc Mechanisms of GII.4 norovirus persistence in human populations
    Lisa C Lindesmith
    University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
    PLoS Med 5:e31. 2008
    ..4 strains is common in human populations. In this article, we analyze molecular mechanisms governing GII.4 epidemiology, susceptibility, and persistence in human populations...
  14. ncbi "Les maladies héréditaires:" 18th century disputes in France
    C López-Beltrán
    Instituto de Investigaciones Filosóficas, Ciudad Universitaria, Mexico
    Rev Hist Sci Paris 48:307-50. 1995
    ..These developments turned out to be crucial for the emergence and strength of 19th century French (and European) hereditarianism, in medicine and other fields...
  15. ncbi Biosynthesis and expression of the Sda and sialyl Lewis x antigens in normal and cancer colon
    Nadia Malagolini
    Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    Glycobiology 17:688-97. 2007
    ....
  16. ncbi Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue
    S Nishihara
    Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan
    FEBS Lett 462:289-94. 1999
    ..fucosylated the distal GlcNAc residue of the polylactosamine chain while the other four alpha1,3FUT members, FUT3, FUT4, FUT5 and FUT6, preferentially fucosylated the inner GlcNAc residue...
  17. ncbi FUT4 and FUT9 genes are expressed early in human embryogenesis
    A Cailleau-Thomas
    U 504 INSERM, Universite de Paris Sud XI, 94807 Villejuif, France
    Glycobiology 10:789-802. 2000
    ..b>FUT3, FUT5, FUT6, and FUT7 were not detected by Northern blot...
  18. pmc Knockdown of fucosyltransferase III disrupts the adhesion of circulating cancer cells to E-selectin without affecting hematopoietic cell adhesion
    Xiaoyan Yin
    Department of Biomedical Engineering, Cornell University, 205 Weill Hall, Ithaca, NY 14853, USA
    Carbohydr Res 345:2334-42. 2010
    ..RT-PCR, we demonstrated that FUT4 and FUT7 are the predominant FUTs expressed in hematopoietic cell line, while FUT3 is heavily expressed by multiple cancer cell lines including the prostate cancer cell line MDA PCa2b...
  19. ncbi Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21
    R S McCurley
    Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Genomics 26:142-6. 1995
    ..We have established physical maps of the FUT3-6 loci to study regulation of this gene family...
  20. ncbi [Clinical evaluation of lung abscess diagnosed by transtracheal aspiration]
    M Konishi
    Second Department of Internal Medicine, Nara Medical University
    Kansenshogaku Zasshi 72:1193-6. 1998
    ..A temperature higher than 38 degrees C was present in 12 patients but temperature les than 37 degrees C in 2. Multiple microorganisms were cultured from TTA in 15 patients. A mean of 2...
  21. ncbi Structure-function analysis of human alpha 1-->3fucosyltransferases. A GDP-fucose-protected, N-ethylmaleimide-sensitive site in FucT-III and FucT-V corresponds to Ser178 in FucT-IV
    E H Holmes
    Pacific Northwest Research Foundation, Seattle, Washington 98122, USA
    J Biol Chem 270:8145-51. 1995
    ..These results support the importance of Ser178 of FucT-IV in donor substrate binding and strongly suggest analogous Cys residues are the GDP-fucose protectable, N-ethylmaleimide-sensitive sites present in FucT-III and -V...
  22. ncbi Exploring specificity of glycosyltransferases: synthesis of new sugar nucleotide related molecules as putative donor substrates
    Amira Khaled
    Glycochimie Moléculaire et Macromoléculaire, Laboratoire de Chimie Organique Multifonctionnelle, UMR 8182, Institut de Chimie Moleculaire et des Materiaux d Orsay, Batiment 420, Univ Paris Sud, F 91405 Orsay, France
    Carbohydr Res 343:167-78. 2008
    ..The surrogate of UDP-GlcNAc that was already known as its protected acetylated derivative, tested as N-acetylglucosamine donor with LgtA in the presence of Mn(2+) turned out not to be active either...
  23. ncbi Complete genomic organization of futb encoding a bovine alpha 3-fucosyltransferase: exons in human orthologous genes emerged from ancestral intronic sequences
    A Wierinckx
    Unité de Génétique Moléculaire Animale Université INRA, Universite de Limoges, France
    Mol Biol Evol 16:1535-47. 1999
    ..A short sequence of the latter is homologous to distinct 5'-UT exons of FUT6 (alpha 3-fucosylation) and FUT3 (alpha 4-fucosylation), two human genes whose coding sequences are homologous to coding exon e of futb...
  24. ncbi Synthesis of unnatural sugar nucleotides and their evaluation as donor substrates in glycosyltransferase-catalyzed reactions
    Amira Khaled
    Laboratoire de Chimie Organique Multifonctionnelle, UMR 8614, GDR 2590, Institut de Chimie Moléculaire et des Matériaux d Orsay ICMMO, Universite Paris Sud, Bat 420, F 91405 Orsay, France
    Carbohydr Res 339:2641-9. 2004
    ..1% efficiency as compared with UDP-GlcNAc, the natural donor substrate...
  25. ncbi Histo-blood group antigen and human milk oligosaccharides: genetic polymorphism and risk of infectious diseases
    Jacques Le Pendu
    INSERM U419, Institut de Biologie, 9 quai Moncousu, F 44093, Nantes, France
    Adv Exp Med Biol 554:135-43. 2004
    ..Their biosynthesis largely is controlled by the enzyme products of alleles at the ABO, FUT2 and FUT3 loci. We have shown that Norwalk virus (NV) uses structures based on H type 1 as its primary receptor...
  26. ncbi [Identification of the hemolytic transfusion reaction caused by lewis antibody using serological and molecular biological methods]
    Xiao zhen Hong
    Institute of Transfusion Medicine, Ministry of Health, Hangzhou, 310006, Zhejiang Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 16:1192-5. 2008
    ..phenotype was identified by using anti-Le(a) and anti-Le(b) blood grouping reagents and the entire coding region of FUT3 gene was amplified by PCR and sequenced directly...
  27. ncbi Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3-FUT5-FUT6 cluster
    A Oulmouden
    Institut de Biotechnologie, Faculte des Sciences, Universite de Limoges, 87060 Limoges, France
    J Biol Chem 272:8764-73. 1997
    Only one bovine gene, corresponding to the human cluster of genes FUT3-FUT5-FUT6, was found by Southern blot analysis. The cognate bovine alpha(1,3)-fucosyltransferase shares 67.3, 69.0, and 69...
  28. doi Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression
    Rickard Nordén
    Department of Virology, University of Gothenburg, Guldhedsgatan 10B, Goteborg, Sweden
    Arch Virol 155:305-13. 2010
    ..Lewis X in infected cells by activating transcription of three normally silent host glycosyltransferase genes, FUT3, FUT5, and FUT6, a process that is initiated by binding of viral RNA to cellular protein kinase R...
  29. ncbi Effect of N-acetylglucosaminyltransferase V on the expressions of other glycosyltransferases
    Peng Guo
    Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, Shanghai Medical College, Fudan University, Shanghai 200032, PR China
    FEBS Lett 562:93-8. 2004
    ..However, it did not cause the increase of SLe(x) synthesis. Transfection of antisense GnTV into H7721 cells showed entirely opposite effects on the expression of above-mentioned SLe(x) and glycosyltransferases as the sense GnTV...
  30. ncbi Development and application of a high resolution liquid chromatographic method for the analysis of complex pigment distributions
    R L Airs
    Department of Chemistry, University of York, Heslington, UK
    J Chromatogr A 917:167-77. 2001
    ..significantly more pigment components in extracts from a sediment (Priest Pot, Cumbria, UK), a microbial mat (les Salines de la Trinital, South Catalonia, Spain) and a culture (C...
  31. ncbi Substrate and donor specificity of glycosyl transferases
    B Ernst
    University of Basel, Institute of Molecular Pharmacy, Switzerland
    Glycoconj J 16:161-70. 1999
    ..A survey of the involved enzymes: beta(1-3) and beta(1-4)galactosyl transferases, alpha(2-3)sialyl transferase, FucT III and FucT VI reveals that the enzymatic synthesis is highly efficient for the rapid preparation of sialyl Lewis(x)-..
  32. doi Polymorphisms of Lewis and Secretor genes are related to breast cancer and metastasis in axillary lymph nodes
    Debora Barreto Teresa
    School of Pharmaceutical Sciences, UNESP, University of Sao Paulo State, Rua Expedicionários do Brasil, 1621, 14 801 902, Araraquara, Sao Paulo, Brazil
    Tumour Biol 31:401-9. 2010
    ..Nonsecretor genotype was associated with axillary lymph node metastasis (P = 0.0149). In conclusion, Lewis and Secretor genotyping could be useful to predict respectively breast cancer susceptibility and axillary lymph nodes metastasis...
  33. doi Difucosylated oligosaccharide Lewis Y is contained within integrin αvβ3 on RL95-2 cells and required for endometrial receptivity
    Dongmei Zhang
    Department of Biochemistry and Molecular Biology, Dalian Medical University, Liaoning Provincial Core Lab of Glycobiology and Glycoengineering, Dalian, People s Republic of China
    Fertil Steril 95:1446-51.e1. 2011
    ..To investigate whether Lewis Y (LeY) carried by integrin αvβ3 influences integrin αvβ3-mediated adhesion in an in vitro implantation model...
  34. ncbi Lewis(y) antigen (CD174) and apoptosis in gastric and colorectal carcinomas: correlations with clinical and prognostic parameters
    S E Baldus
    Intitute of Pathology, University of Duesseldorf, Duesseldorf, Germany
    Histol Histopathol 21:503-10. 2006
    Lewis(y) (Le(y)), also designated CD174, represents a carbohydrate blood group antigen which is strongly expressed in neoplastic gastrointestinal tissues. Previous reports indicated an association between Le(y) expression and apoptosis...
  35. doi [Genetic susceptibility to norovirus infection]
    N Ruvoen
    Unité de maladies réglementées zoonoses, ONIRIS Ecole Nationale Vétérinaire, Agroalimentaire et de l alimentation Nantes Atlantique, Site de la Chantrerie, 44307 Nantes, France
    Pathol Biol (Paris) 61:28-35. 2013
    ..Synthesis of these HBGAs requires various glycosyltransferase encoded by the ABO, FUT2, FUT3 genes...
  36. ncbi Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor
    J Yang
    Center for Hemostasis and Thrombosis Research, Division of Hematology Oncology, New England Medical Center, Boston, MA, USA
    Blood 87:4176-86. 1996
    ..PSGL-1 on mouse myeloid cells is critical for high-affinity binding to P-selectin but not E-selectin...
  37. ncbi Biochemical characterization of Silene alba alpha4-fucosyltransferase and Lewis a products
    R Leonard
    Laboratoire de Chimie des Substances Naturelles, Groupe de Glycobiologie Forestière EA1069, Faculté des Sciences et Techniques de Limoges, Limoges, France
    Glycoconj J 22:71-8. 2005
    ..In contrast to human FUT3, the S. alba alpha4-FucT was insensitive to N-ethylmaleimide (NEM) treatment. Measurement of enzyme activity in S...
  38. ncbi Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines
    C Escrevente
    Instituto de Tecnologia Quimica e Biologica, 2781 901 Oeiras, Portugal
    Int J Oncol 29:557-66. 2006
    ..synthetic carbohydrate acceptors and Western blot analysis we concluded that Lea, sLea and Leb were synthesised by FUT3, whereas Lex and Ley were synthesized by FUT4 and FUT9 in both cell lines...
  39. pmc Molecular characterization of noroviruses and HBGA from infected Quilombola children in Espirito Santo State, Brazil
    Fernando Vicentini
    Departamento de Ciências da Saúde, Universidade Federal do Espirito Santo, São Mateus, Espirito Santo, Brazil
    PLoS ONE 8:e69348. 2013
    ..HBGA phenotype was performed by gel-spinning and FUT2 and FUT3 were analyzed by PCR or sequencing analysis. NoV were detected in 9.2% (12/131) of diarrheic and 1...
  40. doi α3/4 Fucosyltransferase 3-dependent synthesis of Sialyl Lewis A on CD44 variant containing exon 6 mediates polymorphonuclear leukocyte detachment from intestinal epithelium during transepithelial migration
    Jennifer C Brazil
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, GA 30322
    J Immunol 191:4804-17. 2013
    ..Analyses of glycosyltransferase expression identified fucosyltransferase 3 (Fut3) as the key enzyme driving sLe(a) biosynthesis in human intestinal epithelial cells (IECs)...
  41. ncbi Persistent Helicobacter pylori infection and genetic polymorphisms of the host
    Nobuyuki Hamajima
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Japan
    Nagoya J Med Sci 66:103-17. 2003
    ..To date, the associations with the polymorphisms of fucosyl transferase 2 (FUT2 or secretor gene), FUT3 (Lewis gene), interleukin 1A (IL-1A), IL-1B, IL-1RN, IL-8, IL-10, myeloperoxidase (MPO), and tumor necrosis factor ..
  42. doi Virus-induced appearance of the selectin ligand sLeX in herpes simplex virus type 1-infected T-cells: involvement of host and viral factors
    Rickard Nordén
    Department of Infectious Diseases, Sahlgrenska Academy, University of Gothenburg, 41346 Gothenburg, Sweden
    Glycobiology 23:310-21. 2013
    ..found that HSV1 infection of a T-cell line resulted in transcriptional activation of human fucosyltransferase genes FUT3, FUT6 and FUT7, the two latter genes encoding the fucosyltransferases rate limiting for sLeX synthesis...
  43. pmc Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF/bFGF-induced epithelial-mesenchymal transition
    Keiichiro Sakuma
    Division of Molecular Pathology, Aichi Cancer Center, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Proc Natl Acad Sci U S A 109:7776-81. 2012
    ..The transcript levels of the glycosyltransferase genes ST3GAL1/3/4 and FUT3 were significantly elevated and that of FUT2 was significantly suppressed by the treatment...
  44. ncbi Non-isosteric C-glycosyl analogues of natural nucleotide diphosphate sugars as glycosyltransferase inhibitors
    Sébastien Vidal
    Laboratoire de Chimie Organique 2, UMR CNRS 5181, Universite Claude Bernard Lyon 1, CPE Lyon Bâtiment 308, 43 Boulevard du 11 Novembre 1918, F 69622 Villeurbanne, France
    Bioorg Med Chem 14:7293-301. 2006
    ..vitro inhibitory activity of UDP-Gal, GDP-Fuc and UDP-GlcNAc analogues towards glycosyltransferases (beta-1,4-GalT, FUT3 and LgtA) was evaluated through a competition fluorescence assay and IC(50) values of 40 microM, 2 mM and 3...
  45. pmc Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion
    Wesley F Zandberg
    Department of Chemistry, Simon Fraser University, 8888 University Dr, Burnaby V5A 1S6, Canada
    J Biol Chem 287:40021-30. 2012
    ..GDP-5T-Fuc itself does not get transferred by either FUT3 or FUT7 at a measurable rate...
  46. ncbi Chemoenzymatic synthesis of the 3-sulfated Lewisa pentasaccharide
    Annie Malleron
    Laboratoire de Chimie Organique Multifonctionnelle, UMR 8614, GDR 2590, Bat 420, Universite de Paris Sud, F 91405 Orsay, France
    Carbohydr Res 341:29-34. 2006
    ..The fucosylation of the sulfated tetrasaccharide was performed using soluble or immobilized fucosyltransferase FucT-III to give the title compound...
  47. doi The human milk metabolome reveals diverse oligosaccharide profiles
    Jennifer T Smilowitz
    Departments of Food Science and Technology
    J Nutr 143:1709-18. 2013
    ..and products of the FUT2 gene and negative correlations between fucose and products of the fucosyltransferase 3 (FUT3) gene...
  48. doi Noroviruses and histo-blood groups: the impact of common host genetic polymorphisms on virus transmission and evolution
    Nathalie Ruvoën-Clouet
    Unité de maladies réglementées zoonoses, ONIRIS Ecole Nationale Vétérinaire, Agroalimentaire et de l alimentation Nantes Atlantique, Nantes, France INSERM, UMR 892 CNRS, UMR 6299, Universite de Nantes, Nantes, France
    Rev Med Virol 23:355-66. 2013
    ..synthesis of these HBGAs requires the action of several glycosyltransferases that are encoded by the ABO, FUT2, and FUT3 genes...
  49. doi FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis
    Andreas Wannhoff
    Department of Internal Medicine IV, University Hospital of Heidelberg, Heidelberg, Germany
    J Hepatol 59:1278-84. 2013
    ..We aimed at improving diagnostic accuracy of CA19-9 by determining the impact of FUT2/3 genotypes...
  50. pmc C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells
    Catherine A St Hill
    Department of Veterinary Clinical Sciences, University of Minnesota, St Paul, Minnesota, United States of America
    PLoS ONE 6:e16281. 2011
    ..Our findings indicate that C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential...
  51. ncbi A single aromatic amino acid at the carboxyl terminus of Helicobacter pylori {alpha}1,3/4 fucosyltransferase determines substrate specificity
    Bing Ma
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    J Biol Chem 280:36848-56. 2005
    ..Notably, a single aromatic residue (Trp) has also been implicated in controlling Type I acceptor preference for human FucT III, but it is located in an N-terminal hypervariable stem domain.
  52. ncbi Molecular mechanisms of Lewis antigen expression
    Mikiko Soejima
    Department of Forensic Medicine and Human Genetics, Kurume University School of Medicine, Kurume 830 0011, Japan
    Leg Med (Tokyo) 7:266-9. 2005
    ..In this review, we describe the regulation the expression of type 1 Lewis antigens on erythrocytes or digestive organs by two genes (FUT2 and FUT3), and the ethnic specificity of the polymorphism of these genes for forensic use.
  53. ncbi Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cells
    Kristina Nyström
    Department of Virology, University of Goteborg, Goteborg, Sweden
    Glycobiology 17:355-66. 2007
    ..Both viruses induced FUT3, FUT5, and FUT6, encoding alpha1,3- and/or alpha1,4-specific fucosyltransferases...
  54. ncbi [FUT3 gene polymorphism associated with Lewis blood group in Chinese Zhejiang population]
    Xian guo Xu
    Institute of Transfusion Medicine, Blood Center of Zhejiang Province, Key Laboratory of Blood Safety Research, Ministry of Health, Hangzhou 310006, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:601-4. 2006
    To investigate the alpha-1, 3/4-fucosyltransferase gene (FUT3) polymorphism associated with Lewis blood group in Zhejiang population, the Lewis phenotypes of 183 random samples from Chinese blood donors in Zhejiang province were ..
  55. ncbi Binding of sialyl Lewis X antigen to lectin-like receptors on NK cells induces cytotoxicity and tyrosine phosphorylation of a 17-kDa protein
    Koji Higai
    Department of Clinical Chemistry, School of Pharmaceutical Sciences, Toho University, Miyama 2 2 1, Funabashi, Chiba 274 8510, Japan
    Biochim Biophys Acta 1760:1355-63. 2006
    ....
  56. ncbi IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa
    Sophie Groux-Degroote
    Unite de Glycobiologie Structurale et Fonctionnelle, UMR CNRS no 8576, Batiment C9, Universite des Sciences et Technologies de Lille, F 59655 Villeneuve d Ascq, Lille, France
    Biochem J 410:213-23. 2008
    ..a significant increase in the expression of alpha1,3/4-fucosyltransferases [FUT11 (fucosyltransferase 11 gene) and FUT3], alpha2-6- and alpha2,3-sialyltransferases [ST3GAL6 (alpha2,3-sialyltransferase 6 gene) and ST6GAL2 (alpha2,6-..
  57. pmc Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study
    Luc Djousse
    Division of Aging, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am Heart J 153:636-9. 2007
    Previous studies have suggested a positive association between phenotypes of fucosyltransferase 3 (FUT3) gene (also known as Lewis gene) and coronary heart disease.
  58. doi Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab
    Howard M Stern
    Departments of Research Pathology, Development Oncology Diagnostics, and Molecular Oncology, Genentech, Inc, South San Francisco, California, USA
    Clin Cancer Res 16:1587-96. 2010
    ..of the O-glycosylation enzymes GALNT14 in non-small cell lung cancer (NSCLC) cell lines (among others) and of FUT3/6 in colorectal cancer (CRC) cell lines...
  59. pmc Breast cancer humoral immune response: involvement of Lewis y through the detection of circulating immune complexes and association with Mucin 1 (MUC1)
    Marina Isla Larrain
    Centre for Basic and Applied Immunological Research, Faculty of Medical Sciences, National University of La Plata, Buenos Aires, Argentina
    J Exp Clin Cancer Res 28:121. 2009
    ....
  60. doi Co-expression of CD173 (H2) and CD174 (Lewis Y) with CD44 suggests that fucosylated histo-blood group antigens are markers of breast cancer-initiating cells
    Wei Ming Lin
    Laboratory of Molecular and Experimental Pathology, Key Laboratory of Animal Models and Human Disease Mechanisms of CAS and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, China
    Virchows Arch 456:403-9. 2010
    Histo-blood group antigens CD173 (H2) and CD174 (Lewis Y) are known to be developmentally regulated carbohydrate antigens which are expressed to a varying degree on many human carcinomas...
  61. ncbi A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein
    E C Brinkman Van der Linden
    Department of Medical Chemistry, Faculty of Medicine, Van der Boechorststraat 7, Vrije Universiteit, 1081 BT Amsterdam, The Netherlands
    J Biol Chem 271:14492-5. 1996
    ..in the liver, we studied the fucosylation of three glycoproteins in sera of individuals with or without inactivated FUT3 and/or FUT6 gene(s) but with a functional FUT5 gene...
  62. doi Enzymatic synthesis of lacto-N-difucohexaose I which binds to Helicobacter pylori
    Tatsuo Miyazaki
    Department of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences, Akiha ku, Niigata, Japan
    Methods Enzymol 480:511-24. 2010
    ..The obtained pentasaccharide was subsequently incubated with GDP-beta-l-fucose and commercial fucosyltransferase III (FUT3) to attach l-fucose to the d-GlcNAc residue of LNT with an alpha-1,4-linkage...
  63. doi Regulation of glycosyltransferases and Lewis antigens expression by IL-1β and IL-6 in human gastric cancer cells
    Mercè Padró
    Programa de Recerca en Càncer, IMIM Hospital del Mar, 08003 Barcelona, Spain
    Glycoconj J 28:99-110. 2011
    ..IL-1β induced significant increases in the mRNA levels of FUT1, FUT2 and FUT4, and decreases of FUT3 and FUT5. In IL-6 treatments, enhanced FUT1 and lower FUT3 and FUT5 mRNA expression were detected...
  64. doi Activation of host antiviral RNA-sensing factors necessary for herpes simplex virus type 1-activated transcription of host cell fucosyltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) in virus-infected cells
    Rickard Nordén
    Department of Virology, University of Gothenburg, Gothenburg, Sweden
    Glycobiology 19:776-88. 2009
    ..unidentified host factors, eventually resulting in transcription of three dormant host fucosyltransferase genes (FUT3, FUT5, and FUT6), whose gene products are rate-limiting for synthesis of sLe(x)...
  65. pmc Histo-blood group gene polymorphisms as potential genetic modifiers of infection and cystic fibrosis lung disease severity
    JENNIFER L TAYLOR-COUSAR
    Pulmonary Division, Internal Medicine and Pediatrics, Albuquerque, New Mexico, University of New Mexico Health Sciences Center, United States of America
    PLoS ONE 4:e4270. 2009
    ....
  66. ncbi [alpha1,2-fucosyltransferase gene transfection influences on biological behavior of ovarian carcinoma-derived RMG-I cells]
    Ying Ying Hao
    Department of Gynecology and Obstetrics, the Shengjing Hospital of China Medical University, Shenyang 110004, China
    Fen Zi Xi Bao Sheng Wu Xue Bao 41:435-42. 2008
    ..These findings indicate that alpha1,2-FT and Lewis y antigen have the ability to enhance the proliferation and elevate the survival rates of RMG-I cells, which can promote the genesis and development of ovarian carcinoma...
  67. doi Human noroviruses recognize sialyl Lewis x neoglycoprotein
    Gustaf E Rydell
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
    Glycobiology 19:309-20. 2009
    ..using virus-like particles (VLPs) and saliva samples from 81 individuals genotyped for FUT2 (secretor) and FUT3 (Lewis) and phenotyped for ABO and Lewis blood groups...
  68. pmc Gender differences in genetic risk profiles for cardiovascular disease
    Kaisa Silander
    Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland
    PLoS ONE 3:e3615. 2008
    ..We aimed to estimate whether the genetic risk profiles of coronary heart disease (CHD), ischemic stroke and the composite end-point of CVD differ between the genders...
  69. doi Overexpression of Lewis(y) antigen protects ovarian cancer RMG-1 cells from carboplatin-induced apoptosis by the upregulation of Topo-I and Topo-II β
    Changzhi Wang
    Department of Obstetrics and Gynecology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, People s Republic of China
    Anat Rec (Hoboken) 294:961-9. 2011
    ..Therefore, the inhibition of Lewis (y) antigen may be a novel strategy of cancer chemotherapy...
  70. doi Core saccharide dependence of sialyl Lewis X biosynthesis
    Jonas Löfling
    Division of Clinical Immunology and Transfusion Medicine, F79, Karolinska Institute, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Glycoconj J 26:33-40. 2009
    ..Our results define the specificities of FucT-III-VII in SLe(x) biosynthesis on O-glycans with different core structures and the fine specificity of the widely used anti-SLe(x) monoclonal antibody, KM93...
  71. doi Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers
    Sylvain Julien
    Breast Cancer Biology, King s College London, Guy s Hospital, London, United Kingdom
    Cancer Res 71:7683-93. 2011
    ..We found that genes involved in the synthesis of sialyl-Lewis x (sLe(x); FUT3, FUT4, and ST3GAL6) are significantly increased in estrogen receptor alpha-negative (ER-negative) tumors compared ..
  72. ncbi Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation
    Jacinta Serpa
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Cancer Lett 242:191-7. 2006
    ..intestinal metaplasia (IM) and gastric carcinoma (GC), and can be partly due to overexpression of the Lewis (FUT3) enzyme...
  73. ncbi Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19
    I Reguigne-Arnould
    INSERM U 178, Villejuif, France
    Cytogenet Cell Genet 71:158-62. 1995
    ..7) and 9 cM proximal to D19S571 (lod score 11.7). Polymorphic markers of FUT3, FUT5, and FUT6 were used for linkage analysis with 14 Généthon microsatellites in Indonesian families...
  74. ncbi Molecular analysis of secretor type alpha(1,2)-fucosyltransferase gene mutations in the Chinese and Thai populations
    J G Chang
    Department of Medical Research and Pediatrics, China Medical College Hospital, Taichung, Taiwan
    Transfusion 39:1013-7. 1999
    ..of fucosyltransferase genes alpha(1,2)-fucosyltransferase (FUT2 or Se) and alpha(1,3/1,4)-fucosyltransferase (FUT3 or Le), are responsible for the polymorphism of Lewis blood group phenotypes...
  75. ncbi The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand
    K L Koszdin
    Ciba Geigy Corp, Summit, NJ 07901
    Biochem Biophys Res Commun 187:152-7. 1992
    ..The substrate specificity of the FucT-VI gene product suggests that FucT-VI may be an enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis x, in myeloid cells...
  76. ncbi Human alpha 1,3/4 fucosyltransferases. Characterization of highly conserved cysteine residues and N-linked glycosylation sites
    E H Holmes
    Department of Cell Surface Biochemistry, Molecular Medicine, Northwest Hospital, Seattle, Washington 98134, USA
    J Biol Chem 275:24237-45. 2000
    ..Among the human FucTs is a subset of enzymes (FucT III, V, and VI) having highly homologous sequences, especially in the catalytic domain, and Cys residues in FucT III ..
  77. ncbi Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI family heart study
    V Salomaa
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    J Intern Med 247:689-98. 2000
    ..An additional objective was to explore the hypothesis that these mutations are associated with coronary heart disease and inflammatory reaction...
  78. pmc Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells
    S Schnyder-Candrian
    Institute of Physiology, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 97:8369-74. 2000
    ..Storage of a fucosyltransferase in Weibel-Palade bodies suggests a function independent of Golgi-associated glycosylation...
  79. ncbi A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes
    N Ikeda
    Department of Biochemistry and Department of Surgery, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Biol Chem 276:38588-94. 2001
    ..The present remodeling system might be of potential use as a tool for the study of the physiological roles of 3'-sulfated Lewis epitopes, including interaction with selectins...
  80. ncbi Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody
    Y Ikehara
    Division of Oncological Pathology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Cancer Epidemiol Biomarkers Prev 10:971-7. 2001
    ..Immunohistochemical analysis supported the finding that Se and Le genotypes affected the expression of H. pylori adhesin ligands. We conclude that Se and Le genotypes affect susceptibility to H. pylori infection...
  81. ncbi [Belgian law on the Régime de l'alcool of 1919: from the individual measures to social well-being]
    R Campos
    Departamento de Historia de la Ciencia, , CSIC
    Cuad Complut Hist Med Cienc 2:275-94. 1993
    ..The promulgation of "La loi sur le Régime de l'alcool" and "La loi concernant les débits des Boissons Fermentés" on August 29 1919 was the final step in this change in opinion...
  82. ncbi Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia
    S Yazawa
    Japan Immunoresearch Laboratories, Takasaki, Japan
    Exp Clin Immunogenet 16:125-30. 1999
    ..Genotyping of the Le gene (FUT3) in these patients demonstrated that 2 of them were also FUT3 deficient and were grouped as Lewis- individuals ..
  83. ncbi Expression of human alpha(1,3)fucosyltransferase antisense sequences inhibits selectin-mediated adhesion and liver metastasis of colon carcinoma cells
    B W Weston
    The Lineberger Comprehensive Cancer Center, Department of Pediatrics, University of North Carolina, Chapel Hill 27599 7220, USA
    Cancer Res 59:2127-35. 1999
    ..by stable transfection of antisense sequences directed at the human Lewis alpha(1,3/1,4)fucosyltransferase gene, FUT3. The metastatic parental cell line, HT-29LMM, expressed high levels of sialyl Lewis x, sialyl Lewis a, alpha(1,3/1,..
  84. ncbi Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19
    S Nishihara
    Division of Cell Biology, Soka University, Tokyo, Japan
    Biochem Biophys Res Commun 190:42-6. 1993
    ..These genes were present 13 kb apart in tandem orientation. The FucT-III gene has already been mapped on the Lewis locus of chromosome 19. This demonstrated that FucT-VI gene was localized close to the Lewis locus on chromosome 19...
  85. ncbi Molecular genetic analysis of the human Lewis histo-blood group system
    S Nishihara
    Division of Cell Biology, Soka University, Tokyo, Japan
    J Biol Chem 269:29271-8. 1994
    ..The frequency of occurrence of Le, le1, and le2 in the Japanese population by random sampling study was found to be 66, 30, and 4%, respectively...
  86. ncbi Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees
    R Mollicone
    INSERM U 178, Villejuif, France
    J Biol Chem 269:20987-94. 1994
    ..They are synthesized by two fucosyltransferases, encoded by Lewis (FUT3) and secretor (FUT2) loci...
  87. ncbi Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals
    Y Koda
    Department of Legal Medicine, School of Medicine, Kurume University, Japan
    Blood 82:2915-9. 1993
    ..We isolated the protein-coding region of the Lewis FT cDNA from Le(+) and Le(-) gastric mucosa by polymerase chain reaction (PCR) amplification...
  88. ncbi Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals
    T Kudo
    Division of Cell Biology, Institute of Life Science, Soka University, Tokyo, Japan
    J Biol Chem 271:9830-7. 1996
    ..The phylogenic aspect and biological significance of the Se and Le genes are discussed...
  89. ncbi Significance of individual point mutations, T202C and C314T, in the human Lewis (FUT3) gene for expression of Lewis antigens by the human alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII
    A Elmgren
    Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    J Biol Chem 272:21994-8. 1997
    The Lewis alpha(1,3/1,4)-fucosyltransferase, Fuc-TIII, encoded by the FUT3 gene is responsible for the final synthesis of Lea and Leb antigens...
  90. ncbi Evolution of fucosyltransferase genes in vertebrates
    M Costache
    INSERM U178, Universite de Paris Sud XI, 94807 Villejuif Cedex, France
    J Biol Chem 272:29721-8. 1997
    Cloning and expression of chimpanzee FUT3, FUT5, and FUT6 genes confirmed the hypothesis that the gene duplications at the origin of the present human cluster of genes occurred between: (i) the great mammalian radiation 80 million years ..
  91. ncbi Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines
    E Mas
    INSERM U 260, Unité de Recherche de Physiopathologie des Régulations Hormono Nutritionnelles, Faculte de Medecine, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Glycobiology 8:605-13. 1998
    ..Transcripts of FUT1, FUT2, FUT3, FUT4, FUT5, and FUT7 were detected by RT-PCR in carcinoma cell lines as well as in normal and tumoral tissues...
  92. ncbi Determination of Lewis FUT3 gene mutations by PCR using sequence-specific primers enables efficient genotyping of clinical samples
    A Grahn
    Institute of Laboratory Medicine, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Hum Mutat 18:358-9. 2001
    ..reaction method using sequence-specific primers (PCR-SSP) for rapid and correct genotyping of the common Lewis (FUT3) gene mutations 59T>G, 202T>C, 314C>T, 508G>A, and 1067T>A...
  93. ncbi Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study
    B Cakir
    Department of Public Health, Faculty of Medicine, Hacettepe University, Ankara, Turkey
    J Intern Med 255:40-51. 2004
    ..Lewis genotyping included four major mutations of the Lewis (FUT3) gene at nucleotide positions 59, 1067, 202 and 314.
  94. ncbi Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain
    Fabrice Dupuy
    Unité de Génétique Moléculaire Animale, UMR 1061 Université INRA, GDR CNRS 2590, Institut des Sciences de la Vie et de la Santé, Faculte des Sciences et Techniques, 87060 Limoges, France
    Glycobiology 14:347-56. 2004
    ..FUT6 and FUTb enzymes, harboring R in the acceptor-binding motif, transfer fucose in alpha1,3 linkage, whereas FUT3 and FUT5 enzymes with W at the candidate position can also transfer fucose in alpha1,4 linkage-FUT3 being more ..
  95. ncbi Association of Lewis and Secretor gene polymorphisms and Helicobacter pylori seropositivity among Japanese-Brazilians
    Sueli Mieko Oba-Shinjo
    Department of Neurology, School of Medicine, University of Sao Paulo, Av Dr Arnaldo, 455, 4th Floor, Room 4110, Cerqueira Cesar, 01246 903, Sao Paulo, SP, Brazil
    J Gastroenterol 39:717-23. 2004
    ..The present work aims to investigate the associations between Se and Le gene polymorphisms and H. pylori infection among Japanese-Brazilians...
  96. ncbi ABO blood type, Lewis and Secretor genotypes, and chronic atrophic gastritis: a cross-sectional study in Japan
    Atsuko Shibata
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA
    Gastric Cancer 6:8-16. 2003
    ..Such host factors as Le and Se genotypes and ABO blood type may affect the establishment of H. Pylori infection and, once infected, the risk of chronic atrophic gastritis...
  97. ncbi Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides
    Akiko Tsuchida
    Department of Biochemistry II, Nagoya University School of Medicine, 65 Tsurumai, Showa Ku, Nagoya, 466 0065, Japan
    J Biol Chem 278:22787-94. 2003
    ..Therefore, it appears that ST6GalNAc V/VI and fucosyltransferase III (FUT-3) compete for sialyl Lc4, their common substrate...
  98. ncbi Importance of Cys, Gln, and Tyr from the transmembrane domain of human alpha 3/4 fucosyltransferase III for its localization and sorting in the Golgi of baby hamster kidney cells
    Victor L Sousa
    Laboratory of Glycobiology, Instituto de Tecnologia Quimica e Biologica, Apartado 127, 2780 Oeiras, Portugal
    J Biol Chem 278:7624-9. 2003
    Human fucosyltransferase III (EC ) (FT3wt) is localized in the Golgi of baby hamster kidney cells and synthesizes Lewis determinants associated with cell adhesion events...
  99. ncbi Distribution of Lewis (FUT3)genotype and allele: frequencies in a biethnic United States population
    B Cakir
    Department of Public Health, Hacettepe University Faculty of Medicine, Ankara, Turkey
    Ann Hematol 81:558-65. 2002
    ..distribution of four major single nucleotide polymorphisms (SNPs) (T59G, T1067G, T202C, and C314T) of the Lewis ( FUT3)gene in a biethnic United States population...

Research Grants19

  1. Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.
    Ardythe Morrow; Fiscal Year: 2009
    ..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
  2. Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.
    Ardythe Morrow; Fiscal Year: 2009
    ..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
  3. Novel genetic and salivary glycan biomarkers for risk of NEC in ELBW infants.
    Ardythe L Morrow; Fiscal Year: 2010
    ..Sialyl Lewis a (sLe ) is a major glycan produced by the combined catalytic function of transferases encoded by the FUT3 and a2-3 sialyl transferase genes...
  4. Distinctive Glycan Fingerprints of Pancreatic Cancer for Plasma Detection
    David E Misek; Fiscal Year: 2010
    ..These early detection biomarkers may have the utility to facilitate early detection of this deadly malignancy. ..
  5. Role of sLeX-modified O-glycans in carcinoma metastasis
    Catherine St Hill; Fiscal Year: 2007
    ..This K08 award will strengthen the candidate's knowledge of cancer biology and ultimately provide her with the mentoring, skills, and resources needed to achieve her goal to be an independent academic clinical scientist. ..
  6. Fatty Acids and Heart Failure in the Physicians' Health Study
    Luc Djousse; Fiscal Year: 2010
    ....
  7. Genetic Factors and Cardiovascular Disease
    Luc Djousse; Fiscal Year: 2005
    ..Lastly, we will use data collected on participants of the GENCAC study to evaluate these genetic factors in relation to coronary calcification, a measure of coronary atherosclerosis. ..
  8. Genetic Modifiers in CF: Role of ABH polymorphisms
    JENNIFER TAYLOR COUSAR; Fiscal Year: 2006
    ..1) Determine whether polymorphisms in genes in the ABH pathway (including ABO, FUT2 [Secretor status], and FUT3 [Lewis antigen]) segregate with "severe" or "mild" lung disease, or with CF pathogen colonization; (2) Determine ..
  9. EXPERIMENTAL THERAPY OF COLON CANCER WITH ANTISENSE FUTS
    Brent Weston; Fiscal Year: 2004
    ..of these glycans on human colon cancer cells is largely controlled by the alpha(1,3)fucosyltransferases FUT3 and FUT6...
  10. Fatty Acids and Heart Failure in the Physicians' Health Study
    Luc Djousse; Fiscal Year: 2009
    ....