FTO

Summary

Gene Symbol: FTO
Description: fat mass and obesity associated
Alias: alpha-ketoglutarate-dependent dioxygenase FTO, fat mass and obesity-associated protein, protein fto
Species: human

Top Publications

  1. ncbi Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
  2. ncbi The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
  3. ncbi A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
  4. ncbi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
  5. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
  6. ncbi Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
  7. ncbi Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    Frida Renstrom
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Hum Mol Genet 18:1489-96. 2009
  8. ncbi Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    John R Speakman
    Division of Obesity and Metabolic Health, Rowett Research Institute, Aberdeen, Scotland, UK
    Obesity (Silver Spring) 16:1961-5. 2008
  9. ncbi Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Am J Clin Nutr 90:425-8. 2009
  10. ncbi Life course variations in the associations between FTO and MC4R gene variants and body size
    Rebecca Hardy
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
    Hum Mol Genet 19:545-52. 2010

Research Grants

  1. Pharmacogenomics of Gastric Function & Weight in Obesity
    MICHAEL L CAMILLERI; Fiscal Year: 2010
  2. FUNCTIONALLY TETHERED OLIGONUCLEOTIDES
    Gregory Verdine; Fiscal Year: 1993
  3. Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
    Sonia Caprio; Fiscal Year: 2010
  4. PET TRACERS FOR MYOCARDIAL FATTY ACID OXIDATION
    Timothy DeGrado; Fiscal Year: 2003
  5. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2009
  6. Chemistry and Mechanism of Direct DNA Repair Proteins
    Chuan He; Fiscal Year: 2010
  7. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    David B Allison; Fiscal Year: 2011
  8. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    RUDOLPH L contact LEIBEL; Fiscal Year: 2010
  9. MORBIDITY AND MORTALITY RELATED TO GASTRIC BYPASS SURGERY
    Steven Hunt; Fiscal Year: 2009
  10. GENCAC - Utah Field Center
    Steven Hunt; Fiscal Year: 2004

Detail Information

Publications222 found, 100 shown here

  1. ncbi Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    Cristen J Willer
    Genetic Investigation of ANthropometric Traits Consortium
    Nat Genet 41:25-34. 2009
    Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans...
  2. ncbi The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase
    Thomas Gerken
    Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
    Science 318:1469-72. 2007
    Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans...
  3. ncbi A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    Timothy M Frayling
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter, UK
    Science 316:889-94. 2007
    ..A genome-wide search for type 2 diabetes-susceptibility genes identified a common variant in the FTO (fat mass and obesity associated) gene that predisposes to diabetes through an effect on body mass index (BMI)...
  4. ncbi Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    Gudmar Thorleifsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:18-24. 2009
    ..6 x 10(-7). This includes previously identified variants close to or in the FTO, MC4R, BDNF and SH2B1 genes, in addition to variants at seven loci not previously connected with obesity.
  5. ncbi Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
    We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12...
  6. ncbi Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
    Angelo Scuteri
    Unità Operativa Geriatria, Istituto per la Patologia Endocrina e Metabolica, Rome, Italy
    PLoS Genet 3:e115. 2007
    ..Initial analysis suggested that several SNPs in the FTO and PFKP genes were associated with increased BMI, hip circumference, and weight...
  7. ncbi Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    Frida Renstrom
    Department of Public Health and Clinical Medicine, Umea University Hospital, Umea, Sweden
    Hum Mol Genet 18:1489-96. 2009
    Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
  8. ncbi Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    John R Speakman
    Division of Obesity and Metabolic Health, Rowett Research Institute, Aberdeen, Scotland, UK
    Obesity (Silver Spring) 16:1961-5. 2008
    The FTO gene has significant polymorphic variation associated with obesity, but its function is unknown...
  9. ncbi Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene
    Karani S Vimaleswaran
    MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge CB2 0QQ, United Kingdom
    Am J Clin Nutr 90:425-8. 2009
    Intronic variation in the FTO (fat mass and obesity-associated) gene has been unequivocally associated with increased body mass index (BMI; in kg/m(2)) and the risk of obesity in populations of different ethnicity.
  10. ncbi Life course variations in the associations between FTO and MC4R gene variants and body size
    Rebecca Hardy
    MRC Unit for Lifelong Health and Ageing, Department of Epidemiology and Public Health, University College London, 33 Bedford Place, London, UK
    Hum Mol Genet 19:545-52. 2010
    ..We genotyped variants in FTO (rs9939609) and near MC4R (rs17782313) in 1240 men and 1239 women born in 1946 and participating in the MRC ..
  11. ncbi Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ..After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2...
  12. ncbi Physical activity and the association of common FTO gene variants with body mass index and obesity
    Evadnie Rampersaud
    Department of Medicine, University of Maryland, Baltimore, USA
    Arch Intern Med 168:1791-7. 2008
    Common FTO (fat mass and obesity associated) gene variants have recently been associated with body mass index (BMI) and obesity in several large studies...
  13. ncbi The fat mass- and obesity-associated locus and dietary intake in children
    Nicholas J Timpson
    MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
    Am J Clin Nutr 88:971-8. 2008
    A region of chromosome 16 containing the fat mass-and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity.
  14. ncbi The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis
    Kerstin Wahlen
    Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    J Lipid Res 49:607-11. 2008
    We investigated the rs9939609 single nucleotide polymorphism of the FTO gene in relation to fat cell function and adipose tissue gene expression in 306 healthy women with a wide range in body mass index (18-53 kg/m(2))...
  15. ncbi A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    Laura J Scott
    Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Science 316:1341-5. 2007
    ..genes IGF2BP2 and CDKAL1 and the region of CDKN2A and CDKN2B, and confirm that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T2D risk...
  16. ncbi Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity
    Emily Sonestedt
    Department of Clinical Sciences in Malmo, Nutrition Epidemiology, Lund University, Malmo, Sweden
    Am J Clin Nutr 90:1418-25. 2009
    The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation.
  17. ncbi Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    Dharambir K Sanghera
    Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    BMC Med Genet 9:59. 2008
    ..expressed homeobox (HHEX; rs 1111875); transcription factor-7-like 2 (TCF7L2; rs 10885409); potassium inwardly rectifying channel subfamily J member 11(KCNJ11; rs 5219); and fat mass obesity-associated gene (FTO; rs 9939609)].
  18. ncbi PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population
    Cheng Hu
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai, China
    PLoS ONE 4:e7643. 2009
    ..In this study, we attempt to analyze the independent and joint effect of variants from these loci on type 2 diabetes and clinical phenotypes related to glucose metabolism...
  19. ncbi The FTO gene rs9939609 obesity-risk allele and loss of control over eating
    Marian Tanofsky-Kraff
    Unit on Growth and Obesity, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD
    Am J Clin Nutr 90:1483-8. 2009
    Children with rs9939609 FTO variant alleles (homozygous = AA and heterozygous = AT) are predisposed to greater adiposity than are those with 2 wild-type alleles (TT).
  20. ncbi Prevalence of loss-of-function FTO mutations in lean and obese individuals
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Diabetes 59:311-8. 2010
    Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to diet-induced obesity...
  21. ncbi An obesity-associated FTO gene variant and increased energy intake in children
    Joanne E Cecil
    Bute Medical School, University of St Andrews, St Andrews, United Kingdom
    N Engl J Med 359:2558-66. 2008
    Variation in the fat mass and obesity-associated (FTO) gene has provided the most robust associations with common obesity to date. However, the role of FTO variants in modulating specific components of energy balance is unknown.
  22. ncbi FTO variants are associated with obesity in the Chinese and Malay populations in Singapore
    Jonathan T Tan
    Center for Molecular Epidemiology, National University of Singapore, Singapore, Singapore
    Diabetes 57:2851-7. 2008
    Association between genetic variants at the FTO locus and obesity has been consistently observed in populations of European ancestry and inconsistently in non-Europeans...
  23. ncbi Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...
  24. ncbi Common body mass index-associated variants confer risk of extreme obesity
    Chris Cotsapas
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Mol Genet 18:3502-7. 2009
    ..We found convincing association to the previously described locus including the FTO gene...
  25. ncbi Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study
    Vanessa Legry
    INSERM, U744, Lille, France
    Metabolism 58:971-5. 2009
    We investigated the association between the rs9939609 (T>A) polymorphism in the FTO (fat mass- and obesity-associated) gene and obesity- and type 2 diabetes mellitus-related phenotypes in the French Multinational MONItoring of Trends and ..
  26. ncbi Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort
    Amanda F Marvelle
    Department of Genetics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 57:1987-91. 2008
    ..The present study investigated the association between candidate variants and obesity-related traits in a sample of 1,886 adult Filipino women from the Cebu Longitudinal Health and Nutrition Survey (CLHNS) cohort...
  27. ncbi Crystal structure of the FTO protein reveals basis for its substrate specificity
    Zhifu Han
    National Institute of Biological Sciences, No 7 Science Park Road, Beijing 102206, China
    Nature 464:1205-9. 2010
    Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity...
  28. ncbi Regulation of Fto/Ftm gene expression in mice and humans
    George Stratigopoulos
    Division of Molecular Genetics, Naomi Berrie Diabetes Center, Columbia University, New York, New York 10032, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1185-96. 2008
    ..studies (GWAS) in European populations have associated a approximately 47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear...
  29. ncbi Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO
    Marcel den Hoed
    Department of Human Biology, Maastricht University, Maastricht, Netherlands
    Am J Clin Nutr 90:1426-32. 2009
    The common rs9939609 single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is associated with adiposity, possibly by affecting satiety responsiveness.
  30. ncbi Clinical risk factors, DNA variants, and the development of type 2 diabetes
    Valeriya Lyssenko
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    N Engl J Med 359:2220-32. 2008
    ..Type 2 diabetes mellitus is thought to develop from an interaction between environmental and genetic factors. We examined whether clinical or genetic factors or both could predict progression to diabetes in two prospective cohorts...
  31. ncbi The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks
    Abel Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, 17007 Girona, Spain
    J Clin Endocrinol Metab 93:1501-5. 2008
    Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single-nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates.
  32. ncbi Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  33. ncbi FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness
    Sofia I I Kring
    Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 3:e2958. 2008
    A common single nucleotide polymorphism (SNP) of FTO (rs9939609, T/A) is associated with total body fatness...
  34. ncbi Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk
    Hana Lango
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabetes 57:3129-35. 2008
    ..Here, we assess the ability of 18 confirmed type 2 diabetes variants to differentiate between type 2 diabetic case and control subjects...
  35. ncbi FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males
    Robert A Scott
    Integrative and Systems Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Hum Genet 18:1339-43. 2010
    Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk...
  36. ncbi Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling
    Marika Kaakinen
    Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland
    Am J Epidemiol 172:653-65. 2010
    The association between variation in the fat mass and obesity-associated (FTO) gene and adulthood body mass index (BMI; weight (kg)/height (m)(2)) is well-replicated...
  37. ncbi Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
    Camilla H Andreasen
    Steno Diabetes Center, Niels Steensens Vej 1, NLC2 13, DK 2820 Gentofte, Denmark
    Diabetes 57:95-101. 2008
    Three independent studies have shown that variation in the fat mass and obesity-associated (FTO) gene associates with BMI and obesity...
  38. ncbi The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study
    Alex S F Doney
    Diabetes Research Group, Biomedical Research Institute, University of Dundee, Dundee, United Kingdom
    Circ Cardiovasc Genet 2:255-9. 2009
    Common variation in the fat mass and obesity (FTO)-related gene is associated with increased body fat and susceptibility to type 2 diabetes...
  39. ncbi FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women
    Yiqing Song
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:2472-80. 2008
    The FTO gene was recently identified as a susceptibility locus for both obesity and type 2 diabetes by whole-genome association analyses of several European populations...
  40. ncbi Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population
    Shigeru Karasawa
    Third Department of Internal Medicine, Yamagata University Faculty of Medicine, Yamagata, Japan
    Endocr J 57:293-301. 2010
    The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study...
  41. ncbi The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924
    Josefin A Jacobsson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    BMC Med Genet 10:131. 2009
    Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies...
  42. ncbi The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study
    Tiina J Lappalainen
    School of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research Centre, University of Kuopio, Kuopio, Finland
    Obesity (Silver Spring) 17:832-6. 2009
    The common single-nucleotide polymorphism in the FTO (fat mass and obesity associated) gene is consistently associated with an increased risk of obesity...
  43. ncbi Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study
    X Lin
    Discovery Analytics, GlaxoSmithKline, Collegeville, PA, USA
    Diabetologia 52:600-8. 2009
    ....
  44. ncbi Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population
    Yi Cheng Chang
    Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan
    Diabetes 57:2245-52. 2008
    Genetic variants in the fat mass and obesity-associated (FTO) gene have been linked with obesity and type 2 diabetes in European populations...
  45. ncbi Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Rd, Exeter, EX1 2LU, UK
    Diabetes 57:1419-26. 2008
    Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides...
  46. ncbi The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China
    Bo Xi
    Department of Epidemiology, Capital Institute of Pediatrics, 2 Ya Bao Road, 100020 Beijing China
    BMC Med Genet 11:107. 2010
    ..susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults...
  47. ncbi Association of FTO gene variants with adiposity in African-American adolescents
    Sureka Bollepalli
    Division of Endocrinology, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 18:1959-63. 2010
    ..Specifically, variants of the fat mass and obesity associated (FTO) gene have been associated with obesity in populations of European descent...
  48. ncbi Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study
    Jonatan R Ruiz
    Unit for Preventive Nutrition, Department of Biosciences and Nutrition at Novum, Karolinska Institutet, Huddinge, Sweden
    Arch Pediatr Adolesc Med 164:328-33. 2010
    To examine whether physical activity attenuates the effect of the FTO rs9939609 polymorphism on body fat estimates in adolescents.
  49. ncbi Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study
    Jan Bressler
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 5:e10521. 2010
    Single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene are associated with body mass index (BMI) in populations of European descent...
  50. ncbi Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women
    Tariq Ahmad
    Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Diabetes Care 34:675-80. 2011
    Variation in the fat mass and obesity-associated (FTO) gene is associated with obesity. The extent to which separate and combined effects of physical activity and caloric intake modify this association remains unclear.
  51. ncbi Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Obesity (Silver Spring) 17:330-4. 2009
    ..Variation at the fat-mass and obesity-associated (FTO) gene locus has been reported to be associated with increased body fat...
  52. ncbi Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men
    Esther Zimmermann
    Institute of Preventive Medicine, Copenhagen University Hospitals, Centre for Health and Society, Copenhagen, Denmark
    PLoS ONE 4:e4428. 2009
    The A-allele of the single nucleotide polymorphism (SNP), rs9939609, in the FTO gene is associated with increased fatness. We hypothesized that the SNP is associated with morbidity and mortality through the effect on fatness.
  53. ncbi FTO gene variation and measures of body mass in an African population
    Branwen J Hennig
    MRC International Nutrition Group, NPHIRU, EPH, London School of Hygiene and Tropical Medicine, London, UK
    BMC Med Genet 10:21. 2009
    Variation in the fat mass and obesity associated (FTO) gene has been reproducibly associated with body mass index (BMI) and obesity in populations of White European origin. Data from Asians and African-Americans is less conclusive.
  54. ncbi 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    We have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this ..
  55. ncbi Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France
    R Attaoua
    IURC, Molecular Endocrinology Laboratory UMR 204, Montpellier Cedex 5, France
    Diabetes Metab 35:476-83. 2009
    The objective of the present study was to investigate the genetic association of the fat-mass-and-obesity-associated (FTO) gene in obese women in the presence of the known influential role of the insulin receptor substrate 2 (IRS-2) gene.
  56. ncbi Variations in the FTO gene are associated with severe obesity in the Japanese
    Kikuko Hotta
    Laboratory for Obesity, SNP Research Center, RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Hum Genet 53:546-53. 2008
    Variations in the fat-mass and obesity-associated gene (FTO) are associated with the obesity phenotype in many Caucasian populations. This association with the obesity phenotype is not clear in the Japanese...
  57. ncbi Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO)
    Michael Linnebacher
    Department of General, Thoracic, Vascular and Transplant Surgery, University of Rostock, Rostock, Germany
    J Biomed Biotechnol 2010:841451. 2010
    ..Here, we provide conclusive data that the (-1) frame of U79260(FTO) encodes an HLA-A0201-restricted cytotoxic T cell epitope (FSP11; TLSPGWSAV)...
  58. ncbi Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
    Florianne Bauer
    Complex Genetics Section, Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands
    Am J Clin Nutr 90:951-9. 2009
    ..New genetic loci, most of which are expressed in the brain, have recently been reported to contribute to the development of obesity. The brain, especially the hypothalamus, is strongly involved in regulating weight and food intake...
  59. ncbi Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome
    Elisabeth Wehr
    Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University Graz, A 8036 Graz, Austria
    Metabolism 59:575-80. 2010
    Variants in the fat mass and obesity-associated gene (FTO) are associated with obesity and type 2 diabetes mellitus. Women with polycystic ovary syndrome (PCOS) are frequently affected by obesity and impaired glucose tolerance...
  60. ncbi Variation in the FTO gene influences food intake but not energy expenditure
    A Haupt
    Department of Internal Medicine, Division of Diabetology, Endocrinology, Nephrology and Angiology, Clinical Chemistry, University of Tubingen, Tubingen, Germany
    Exp Clin Endocrinol Diabetes 117:194-7. 2009
    Polymorphisms in the FTO (fat mass- and obesity-associated) gene are associated with obesity. The mechanisms how genetic variation in this gene influences body weight are unknown...
  61. ncbi Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain
    José L González-Sánchez
    Department of Internal Medicine II, Hospital Clinico San Carlos, Madrid, Spain
    Clin Endocrinol (Oxf) 70:390-3. 2009
    Recently independent studies, including genome-wide scans, have shown that variation in the fat mass and obesity associated gene (FTO) were significantly associated with obesity in populations of European origin.
  62. ncbi Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome
    T M Barber
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, OX3 7LJ, UK
    Diabetologia 51:1153-8. 2008
    Variants in the fat-mass and obesity-associated gene (FTO) influence susceptibility to type 2 diabetes via an effect on adiposity/obesity...
  63. ncbi Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians
    Maggie C Y Ng
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China
    Diabetes 57:2226-33. 2008
    ..However, the implications of these genes in Asians are unclear...
  64. ncbi Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults
    A Jonsson
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetologia 52:1334-8. 2009
    Recent reports have suggested that genotypes at the FTO locus interact with physical activity to modify levels of obesity-related traits...
  65. ncbi Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany
    Anke Tonjes
    Department of Medicine, Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
    Eur J Hum Genet 18:104-10. 2010
    The association between common variants in the FTO gene with weight, adiposity and body mass index (BMI) has now been widely replicated...
  66. ncbi Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study
    Eryn T Liem
    Department of Pediatrics Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
    Am J Clin Nutr 91:321-8. 2010
    ..Overweight is a complex trait in which both environmental and genetic factors play a role...
  67. ncbi The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients
    Carina Zabena
    Department of Internal Medicine II, Hospital Clinico San Carlos, CIBER de Diabetes y Enfermedades Metabólicas Asociadas CIBERDEM, Cea Bermúdez 66, 5 G, 28003, Madrid, Spain
    Obes Surg 19:87-95. 2009
    ..the fat mass and obesity associated gene (FTO) has been found to contribute to the risk of obesity in humans...
  68. ncbi Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS)
    Susanne Tan
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:12. 2010
    ..We examined the influence of validated genetic variants conferring susceptibility to obesity and/or type 2 diabetes mellitus (T2DM) on metabolic and PCOS-specific traits in patients with PCOS...
  69. ncbi Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction
    B K Cornes
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Int J Obes (Lond) 33:75-9. 2009
    To further investigate a common variant (rs9939609) in the fat mass- and obesity-associated gene (FTO), which recent genome-wide association studies have shown to be associated with body mass index (BMI) and obesity.
  70. ncbi Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls
    S F Field
    Diabetologia 50:2218-20. 2007
  71. ncbi Association of the FTO gene with BMI
    Steven C Hunt
    Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Obesity (Silver Spring) 16:902-4. 2008
    Variants in the FTO gene have been strongly associated with obesity in a very large sample (38,759) of diabetic and control subjects...
  72. ncbi NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium
    Nancy L Heard-Costa
    Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000539. 2009
    ..In stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role of FTO and MC4R and identified one novel locus associated with WC in the neurexin 3 gene [NRXN3 (rs10146997, p = 6...
  73. ncbi Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    David Meyre
    CNRS 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
    Nat Genet 41:157-9. 2009
    ..Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal ..
  74. ncbi Common genetic variation near MC4R is associated with eating behaviour patterns in European populations
    F Stutzmann
    1CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Int J Obes (Lond) 33:373-8. 2009
    Both rs17782313 (near MC4R) and rs1421085 (FTO) polymorphisms have been consistently associated with increased risk of obesity and with body mass index (BMI) variation...
  75. ncbi Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study
    Y Tabara
    Department of Basic Medical Research and Education, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Int J Obes (Lond) 33:1243-8. 2009
    Susceptibility of fat mass and obesity-associated (FTO) gene polymorphisms to obesity has been reported in various populations. Polymorphisms in the melanocortin 4 receptor (MC4R) gene were recently explored as another susceptible locus...
  76. ncbi FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome
    Redha Attaoua
    Molecular Endocrinology Laboratory, IURC, 641 Avenue du Doyen Gaston Giraud, 34093 Montpellier Cedex 5, France
    Biochem Biophys Res Commun 373:230-4. 2008
    The FTO (Fat mass and obesity associated) locus has recently been associated with obesity and type 2 diabetes (T2D) in humans...
  77. ncbi Inverse relationship between obesity and FTO gene expression in visceral adipose tissue in humans
    N Kloting
    Department of Medicine, University of Leipzig, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetologia 51:641-7. 2008
    Recently, FTO was identified as a candidate gene contributing to both childhood and severe adult obesity...
  78. ncbi Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program
    P W Franks
    Genetic Epidemiology and Clinical Research Group, Department of Public Health and Clinical Medicine, Section for Medicine, Umea University Hospital, Umea, Sweden
    Diabetologia 51:2214-23. 2008
    The single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity associated gene (FTO) and the rs7566605 SNP located 10 kb upstream of the insulin-induced gene 2 gene (INSIG2) have been proposed as risk factors for common ..
  79. ncbi The FTO gene is associated with adulthood obesity in the Mexican population
    Marisela Villalobos-Comparan
    Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Instituto de Investigaciones Biomédicas de la Universidad Nacional Autónoma de México, Mexico City, Mexico
    Obesity (Silver Spring) 16:2296-301. 2008
    Common polymorphisms in the fat mass and obesity-associated gene (FTO) have shown strong association with obesity in several populations...
  80. ncbi Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents
    J A Jacobsson
    Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden
    Int J Obes (Lond) 32:1730-5. 2008
    ..Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity...
  81. ncbi Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
  82. ncbi The Common FTO Genetic Polymorphism rs9939609 is Associated with Increased BMI in Type 1 Diabetes but not with Diabetic Nephropathy
    Harvest F Gu
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna, Stockholm, Sweden email
    Biomark Insights 5:29-32. 2010
    The fat mass and obesity associated (FTO) gene has an important genetic effect on body mass index (BMI) and risk of obesity, and obesity contributes to the progression of renal diseases, including diabetic nephropathy...
  83. ncbi Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study)
    J K Hertel
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetologia 51:971-7. 2008
    ..To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study)...
  84. ncbi Therapeutic efficacy of hysterosalpingography with special reference to application of hydrostatic pressure during the procedure
    Mehboob Hussain
    College of Medicine, Qassim University, Saudi Arabia
    Int J Health Sci (Qassim) 1:223-7. 2007
    ..women of 18-30 years (mean age=24 years) who were clinically suspected of proximal fallopian tube obstruction (FTO) or unexplained infertility were included in this study...
  85. ncbi Liver-specific enhancer of the glucokinase gene
    P B Iynedjian
    Division of Clinical Biochemistry and Diabetes Research, University of Geneva School of Medicine, 1211 Geneva, Switzerland
    J Biol Chem 271:29113-20. 1996
    ..In FTO-2B hepatoma cells, a differentiated line expressing many liver-specific traits but not the endogenous glucokinase ..
  86. ncbi Genome-wide linkage and peak-wide association study of obesity-related quantitative traits in Caribbean Hispanics
    Chuanhui Dong
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, 1120 NW 14th Street, FL 33136, USA
    Hum Genet 129:209-19. 2011
    ..We then carried out an association analysis of the linkage peaks and the FTO gene in an independent community-based Hispanic subcohort (N = 652, 64% Caribbean Hispanics) from the Northern ..
  87. ncbi Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK
    J Intern Med 269:525-37. 2011
    ..We used genetic variants that are robustly associated with adiposity to examine the causal association of adiposity with psychological distress...
  88. ncbi Posthatching myofiber development in the M. pectoralis of White Pekin Ducks
    U Gille
    Institute of Veterinary Anatomy, University of Leipzig, Germany
    Anat Rec 250:154-8. 1998
    A posthatching transformation of fast-twitch oxidative-glycolytic (FTO) to fast-twitch glycolytic (FTG) fibers in the breast muscle in domestic chickens and turkeys is well documented...
  89. ncbi The fused toes locus is essential for somatic-germ cell interactions that foster germ cell maturation in developing gonads in mice
    Bongki Kim
    Department of Animal Sciences, University of Illinois, Urbana, IL, USA
    Biol Reprod 84:1024-32. 2011
    ..6 Mb of chromosome 8, which includes the entire IrxB cluster (Irx3, Irx5, Irx6), Ftm, Fts, and Fto genes. Homozygote Ft mutant embryos die around embryonic day 13.5 (E13...
  90. ncbi The role of protein synthesis in the decay of phosphoenolpyruvate carboxykinase messenger RNA
    J Hua
    Department of Physiology and Biophysics, State University of New York, Stony Brook 11794 8661
    Mol Endocrinol 6:1418-24. 1992
    ..1.1.32) mRNA turnover was studied in FTO-2B rat hepatoma cells...
  91. ncbi Plasmon polaritons in the near infrared on fluorine doped tin oxide films
    Lorenzo Dominici
    Dept of Energetics, Molecular Photonics Laboratory, Sapienza University, Roma, Italy
    Opt Express 17:10155-67. 2009
    Here we investigate plasmon polaritons in fluorine doped tin oxide (FTO) films. By fitting reflectance and transmittance measurements as a function of wavelength lambda epsilon [1.0microm, 2...
  92. ncbi A non-heme iron-mediated chemical demethylation in DNA and RNA
    Chengqi Yi
    Department of Chemistry, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Acc Chem Res 42:519-29. 2009
    ..that are homologous to AlkB, ABH2 and ABH3, repair the same spectrum of lesions; another human homologue of AlkB, FTO, is linked to obesity...
  93. ncbi Making oxygen with ruthenium complexes
    Javier J Concepcion
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3290, and Laboratory of Photochemistry and Energy Conversion, Instituto de Quimica, Universidade de Sao Paulo, Sao Paulo, Brazil
    Acc Chem Res 42:1954-65. 2009
    ..bpz is 2,2'-bipyrazine) in solution or Ru(4,4'-((HO)(2)P(O)CH(2))(2)bpy)(2)(bpy)(2+) on ITO (ITO/Sn) or FTO (SnO(2)/F) electrodes...
  94. ncbi Influence of prenatal nutrition and obesity on tissue specific fat mass and obesity-associated (FTO) gene expression
    S P Sebert
    Early Life Nutrition Research Unit, School of Clinical Sciences, Academic Child Health, University Hospital, Nottingham NG7 2UH, UK
    Reproduction 139:265-74. 2010
    ..recent discovery of an association between body composition, energy intake and the fat mass and obesity-associated (FTO) gene represents a promising new therapeutic target in obesity prevention...
  95. ncbi Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression
    F Bosch
    Department of Biochemistry and Molecular Biology, School of Veterinary Medicine, Autonomous University of Barcelona, Bellaterra, Spain
    J Biol Chem 267:2888-93. 1992
    ..In addition, phosphoenolpyruvate carboxykinase (PEPCK) gene expression in FTO-2B rat hepatoma cells was inhibited by treatment with LiCl...
  96. ncbi Detailed Investigations of ZnO Photoelectrodes Preparation for Dye Sensitized Solar Cells
    Renata Marczak
    Institute of Particle Technology, Friedrich Alexander University Erlangen Nuremberg, Cauerstr 4, 91058 Erlangen, Germany
    Langmuir 27:3920-9. 2011
    ..ZnO films were prepared by doctor blading ethanolic pastes containing ZnO nanoparticles and ethyl cellulose onto FTO conductive glass substrate followed by calcination...
  97. ncbi Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
    Kikuko Hotta
    Laboratory for Endocrinology and Metabolism, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    J Hum Genet 55:738-42. 2010
    ..methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes...
  98. ncbi Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    OMICS 12:237-44. 2008
    ..in T2DM: CDKAL1, CDK5 regulatory subunit associated protein-like 1; CDKN2, cyclin-dependent kinase inhibitor 2A; FTO, fat mass and obesity associated; HHEX, haematopoietically expressed homeobox; IDE, insulin-degrading enzyme; ..
  99. ncbi FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth
    Gaifen Liu
    Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    BMC Med Genet 11:57. 2010
    Genome-wide association studies found common variants in the fat mass and obesity-associated (FTO) gene associated with adiposity in Caucasians and Asians but the association was not confirmed in African populations...
  100. ncbi Efficiency of occlusion therapy for management of amblyopia in older children
    Gagandeep S Brar
    Department of Ophthalmology, Postgraduate Institute of Medical Education and Research, Chandigarh, Punjab, India
    Indian J Ophthalmol 54:257-60. 2006
    ..To analyse results of full time occlusion therapy for amblyopia in children older than 6 years...
  101. ncbi Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia
    Ge Zhang
    Center for Genome Information, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 5:e10375. 2010
    Multiple studies have provided compelling evidence that the FTO gene variants are associated with obesity measures...

Research Grants84

  1. Pharmacogenomics of Gastric Function & Weight in Obesity
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..g. fat mass and obesity-associated gene, FTO) or type II diabetes mellitus (DM, e.g. TCF7L2)...
  2. FUNCTIONALLY TETHERED OLIGONUCLEOTIDES
    Gregory Verdine; Fiscal Year: 1993
    ..Based on preliminary results obtained in this laboratory, a general FTO synthesis has been devised which incorporates the following features: (i) high chemical yield and ease of ..
  3. Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
    Sonia Caprio; Fiscal Year: 2010
    ..The specific aims are: Aim 1: A) To examine the relationships between a panel of 16 gene variants (TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, CDKAL1, IGF2BP2, SLC30A8, JAZF1, HHEX, CDC123/CAMK1D, WFS1, TSPAN8/LGR5, THADA, ADAMTS9) and ..
  4. PET TRACERS FOR MYOCARDIAL FATTY ACID OXIDATION
    Timothy DeGrado; Fiscal Year: 2003
    ..acid (FTP), and the oleate analog, 1 8-[F- 1 8]fluoro-4-thia-9Z-octadecenoic acid (FTO), in isolated rat heart...
  5. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    Rudolph Leibel; Fiscal Year: 2009
    ..Aim 2 will use mice to address the molecular physiology of a recently discovered pair of adjacent genes (FTO/FTM) - and a related transcription factor, CUTL1 - strongly implicated in obesity by three GWAS; and a gene (MGRN1=..
  6. Chemistry and Mechanism of Direct DNA Repair Proteins
    Chuan He; Fiscal Year: 2010
    ..complexes, will be applied to study other AlkB human homologues, in particular, ABH3, a prostate cancer marker, and FTO, a major factor involved in obesity and energy homeostasis...
  7. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    David B Allison; Fiscal Year: 2011
    ..Aim 2 will use mice to address the molecular physiology of a recently discovered pair of adjacent genes (FTO/FTM) - and a related transcription factor, CUTL1 - strongly implicated in obesity by three GWAS;and a gene (MGRN1=..
  8. MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY
    RUDOLPH L contact LEIBEL; Fiscal Year: 2010
    ..Aim 2 will use mice to address the molecular physiology of a recently discovered pair of adjacent genes (FTO/FTM) - and a related transcription factor, CUTL1 - strongly implicated in obesity by three GWAS;and a gene (MGRN1=..
  9. MORBIDITY AND MORTALITY RELATED TO GASTRIC BYPASS SURGERY
    Steven Hunt; Fiscal Year: 2009
    ..The proposed study which would be the largest of it's kind to date, will provide a wealth of data crucial for surgeons, their patients and policy makers regarding the long-term risks and benefits of RY-GBP surgery. ..
  10. GENCAC - Utah Field Center
    Steven Hunt; Fiscal Year: 2004
    ..abstract_text> ..
  11. The Family Blood Pressure Program (HyperGEN Network)
    Steven Hunt; Fiscal Year: 2007
    ..End of Abstract) ..
  12. GENETIC EPIDEMIOLOGY OF AGING IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2007
    ..This collection of longitudinally followed pedigrees provides a powerful study design to address a wide range of genetic epidemiological analyses of aging. ..
  13. MORBIDITY AND MORTALITY RELATED TO GASTRIC BYPASS SURGERY
    Steven Hunt; Fiscal Year: 2007
    ..The proposed study which would be the largest of it's kind to date, will provide a wealth of data crucial for surgeons, their patients and policy makers regarding the long-term risks and benefits of RY-GBP surgery. ..
  14. MULTIPLE SEVERE OBESITY RISK GENES IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2007
    ..Validation will be tested in a large case/control series, Polynesian families, and, for chromosome 20, in the congenic mouse model. ..
  15. MULTIPLE SEVERE OBESITY RISK GENES IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2009
    ..Validation will be tested in a large case/control series, Polynesian families, and, for chromosome 20, in the congenic mouse model. ..
  16. MORBIDITY & MORTALITY RELATED TO GASTRIC BYPASS SURGERY
    Steven Hunt; Fiscal Year: 2004
    ..abstract_text> ..
  17. MORBIDITY AND MORTALITY RELATED TO GASTRIC BYPASS SURGERY
    Steven Hunt; Fiscal Year: 2009
    ..The proposed study which would be the largest of it's kind to date, will provide a wealth of data crucial for surgeons, their patients and policy makers regarding the long-term risks and benefits of RY-GBP surgery. ..
  18. GENETIC EPIDEMIOLOGY OF AGING IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2002
    ..Twenty-five year changes in these variables will provide an extremely powerful setting to identify specific genes related to aging changes in cardiovascular risk factors. ..
  19. Initiating Factors for Hypertension
    Steven C Hunt; Fiscal Year: 2010
    ..Blood, urine, and DNA will be studied while individuals are infused with a sodium and water solution over a short period of time. Results may suggest better ways to prevent or to at least treat hypertension. ..
  20. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2009
    ....
  21. Genes, Hormomes, Growth, and Body Fat: Project HeartBeat
    DAVID HALLMAN; Fiscal Year: 2007
    ..Our analyses may also help identify genetic variants that may predispose some individuals toward obesity. ..
  22. GENETIC EPIDEMIOLOGY OF CHANGE IN CVD RISK FACTORS
    DAVID MICHAEL HALLMAN; Fiscal Year: 2010
    ....
  23. An association scan for human obesity related genes
    R Arlen Price; Fiscal Year: 2010
    ..The identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. ..
  24. The Genetics of Infant Growth and Later Obesity
    Ellen W Demerath; Fiscal Year: 2010
    ....
  25. Genome-wide Association Scan to Identify Risk Genes for Type 2 Diabetes in Asian
    Dharambir K Sanghera; Fiscal Year: 2010
    ..Identifying the susceptibility loci in a population with high diabetic/cardiovascular risk may be important beyond Indians and will increase our understanding of the disease in other groups. ..
  26. An association scan for human obesity related genes
    R Price; Fiscal Year: 2009
    ..The identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. ..
  27. Genome Wide Association Study for Childhood Obesity
    STRUAN GRANT; Fiscal Year: 2009
    ..This project proposes to study genetic variants that influence the pathogenesis of childhood obesity in two large pediatric cohorts by conducting a genome-wide association study using a high density tag-SNP platform. ..
  28. Multicentric Pooled Analysis of Second Primary Cancer
    Paul Brennan; Fiscal Year: 2004
    ..g., ultraviolet light); (ii) an investigation of rare cancer types (e.g., bone cancer or sarcomas); and (iii) an investigation of second primary cancers which may be increased due to treatment of a first primary cancer (e.g., leukemia). ..
  29. Maternal overnutrition and offspring fat mass, metabolic and vascular function.
    Debbie Lawlor; Fiscal Year: 2007
    ....
  30. Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk r*
    Paul Brennan; Fiscal Year: 2007
    ..The results of a full study have the potential to identify important lifestyle and occupational risk factors for pancreatic cancer and inform future prevention efforts against pancreatic cancer. ..
  31. GENETIC STUDIES OF OBESITY
    R Price; Fiscal Year: 2001
    ..The investigators state that the identification of human obesity genes will improve accuracy of genetic risk estimates, enhance efficacy of prevention programs, and permit the development of effective and specific therapies. ..
  32. GENETIC STUDIES OF OBESITY
    R Price; Fiscal Year: 2007
    ..The identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. ..
  33. FINE LOCALIZATION OF GENES FOR HUMAN OBESITY
    R Price; Fiscal Year: 2004
    ..They further note that the identification of genes for common forms of obesity should lead to more individualized therapies and more effective prevention strategies. ..
  34. International Lung Cancer Consortium: Pooled analysis o*
    Paul Brennan; Fiscal Year: 2006
    ..abstract_text> ..
  35. The Genetics of Infant Growth and Later Obesity
    Ellen Demerath; Fiscal Year: 2006
    ....
  36. Genome Wide Association Study for Childhood Obesity
    Struan F A Grant; Fiscal Year: 2010
    ..This project proposes to study genetic variants that influence the pathogenesis of childhood obesity in two large pediatric cohorts by conducting a genome-wide association study using a high density tag-SNP platform. ..
  37. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2010
    ..abstract_text> ..