FTO

Summary

Gene Symbol: FTO
Description: FTO, alpha-ketoglutarate dependent dioxygenase
Alias: ALKBH9, BMIQ14, GDFD, alpha-ketoglutarate-dependent dioxygenase FTO, AlkB homolog 9, fat mass and obesity associated, fat mass and obesity-associated protein
Species: human
Products:     FTO

Top Publications

  1. Renström F, Payne F, Nordström A, Brito E, Rolandsson O, Hallmans G, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet. 2009;18:1489-96 pubmed publisher
    Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
  2. Willer C, Speliotes E, Loos R, Li S, Lindgren C, Heid I, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34 pubmed publisher
    Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans...
  3. Boissel S, Reish O, Proulx K, Kawagoe Takaki H, Sedgwick B, Yeo G, et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet. 2009;85:106-11 pubmed publisher
    b>FTO is a nuclear protein belonging to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family...
  4. Cotsapas C, Speliotes E, Hatoum I, Greenawalt D, Dobrin R, Lum P, et al. Common body mass index-associated variants confer risk of extreme obesity. Hum Mol Genet. 2009;18:3502-7 pubmed publisher
    ..We found convincing association to the previously described locus including the FTO gene...
  5. Tönjes A, Zeggini E, Kovacs P, Böttcher Y, Schleinitz D, Dietrich K, et al. Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet. 2010;18:104-10 pubmed publisher
    The association between common variants in the FTO gene with weight, adiposity and body mass index (BMI) has now been widely replicated...
  6. Timpson N, Lindgren C, Weedon M, Randall J, Ouwehand W, Strachan D, et al. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes. 2009;58:505-10 pubmed publisher
    ..In the "obese-type 2 diabetes" scan, FTO variants had the strongest type 2 diabetes effect (rs8050136: relative risk [RR] 1.49 [95% CI 1.34-1.66], P = 1...
  7. Hardy R, Wills A, Wong A, Elks C, Wareham N, Loos R, et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet. 2010;19:545-52 pubmed publisher
    ..We genotyped variants in FTO (rs9939609) and near MC4R (rs17782313) in 1240 men and 1239 women born in 1946 and participating in the MRC ..
  8. Hasselbalch A, Angquist L, Christiansen L, Heitmann B, Kyvik K, Sørensen T. A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. J Nutr. 2010;140:831-4 pubmed publisher
    We investigated the role of the fat mass and obesity associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) in modulating habitual intake of total energy and macronutrients, glycemic index, glycemic load, dietary ..
  9. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfalt E, Orho Melander M. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr. 2009;90:1418-25 pubmed publisher
    The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation...

More Information

Publications132 found, 100 shown here

  1. Sovio U, Mook Kanamori D, Warrington N, Lawrence R, Briollais L, Palmer C, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet. 2011;7:e1001307 pubmed publisher
    An age-dependent association between variation at the FTO locus and BMI in children has been suggested...
  2. Jassim G, Fernø J, Theisen F, Haberhausen M, Christoforou A, Håvik B, et al. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry. 2011;44:15-20 pubmed publisher
    ..We genotyped tagSNPs in several genes ( ADIPOQ, PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3, FTO and FABP3) that regulate lipid and energy homeostasis for their possible association to antipsychotic-induced ..
  3. Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. J Hum Genet. 2011;56:647-51 pubmed publisher
    ..are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1...
  4. Lewis S, Murad A, Chen L, Davey Smith G, Donovan J, Palmer T, et al. Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk. PLoS ONE. 2010;5:e13485 pubmed publisher
    ..association study of the relationship between a single nucleotide polymorphism known to be associated with obesity (FTO rs9939609) and prostate cancer...
  5. Corella D, Arnett D, Tucker K, Kabagambe E, Tsai M, Parnell L, et al. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr. 2011;141:2219-25 pubmed publisher
    Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce...
  6. Johnson L, van Jaarsveld C, Emmett P, Rogers I, Ness A, Hattersley A, et al. Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants. PLoS ONE. 2009;4:e4594 pubmed publisher
    ..Children with the FTO (rs9939609) variant that increases the risk of obesity may have a higher susceptibility to the effects of DED ..
  7. Lurie G, Gaudet M, Spurdle A, Carney M, Wilkens L, Yang H, et al. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS ONE. 2011;6:e16756 pubmed publisher
    ..Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity...
  8. Karra E, O Daly O, Choudhury A, Yousseif A, Millership S, Neary M, et al. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest. 2013;123:3539-51 pubmed publisher
    Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity and obesity-prone behaviors, including increased food intake and a preference for energy-dense foods...
  9. Ewens K, Jones M, Ankener W, Stewart D, Urbanek M, Dunaif A, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS ONE. 2011;6:e16390 pubmed publisher
    ..While not associated with PCOS itself, five SNPs in FTO and two in MC4R were associated with BMI as assessed with a quantitative-TDT analysis, several of which replicated ..
  10. Phillips C, Kesse Guyot E, McManus R, Hercberg S, Lairon D, Planells R, et al. High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults. J Nutr. 2012;142:824-31 pubmed publisher
    Fat mass and obesity-associated (FTO) is the strongest genetic determinant of obesity identified to date. Dietary fat is a key environmental factor that may interact with genotype to affect risk of obesity and metabolic syndrome (MetS)...
  11. Deliard S, Panossian S, Mentch F, Kim C, Hou C, Frackelton E, et al. The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry. Obesity (Silver Spring). 2013;21:159-63 pubmed publisher
    Common variation at the loci harboring fat mass and obesity (FTO), melanocortin receptor 4 (MC4R), and transmembrane protein 18 (TMEM18) is consistently reported as being statistically most strongly associated with obesity...
  12. Yajnik C, Janipalli C, Bhaskar S, Kulkarni S, Freathy R, Prakash S, et al. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia. 2009;52:247-52 pubmed publisher
    Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these associations are not consistent in Asians...
  13. Scott R, Bailey M, Moran C, Wilson R, Fuku N, Tanaka M, et al. FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur J Hum Genet. 2010;18:1339-43 pubmed publisher
    Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk...
  14. Yang J, Loos R, Powell J, Medland S, Speliotes E, Chasman D, et al. FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012;490:267-72 pubmed publisher
    ..We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype), is ..
  15. Stratigopoulos G, Martin Carli J, O Day D, Wang L, LeDuc C, Lanzano P, et al. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab. 2014;19:767-79 pubmed publisher
    Common polymorphisms in the first intron of FTO are associated with increased body weight in adults...
  16. Ho A, Stein J, Hua X, Lee S, Hibar D, Leow A, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A. 2010;107:8404-9 pubmed publisher
    A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an approximately 1...
  17. Bressler J, Kao W, Pankow J, Boerwinkle E. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PLoS ONE. 2010;5:e10521 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene are associated with body mass index (BMI) in populations of European descent...
  18. Keller L, Xu W, Wang H, Winblad B, Fratiglioni L, Graff C. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis. 2011;23:461-9 pubmed publisher
    The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes...
  19. Wang H, Dong S, Xu H, Qian J, Yang J. Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis. Mol Biol Rep. 2012;39:5691-8 pubmed publisher
    The objective of this study was to examine the effect of genetic variants in fat mass and obesity associated (FTO) gene on metabolic syndrome (MetS)...
  20. Kowalska I, Adamska A, Malecki M, Karczewska Kupczewska M, Nikolajuk A, Szopa M, et al. Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77:120-5 pubmed publisher
    ..It has recently been shown that the FTO gene modifies weight, fat mass and insulin sensitivity in women with PCOS, where its role might be larger than in ..
  21. Kaklamani V, Yi N, Sadim M, Siziopikou K, Zhang K, Xu Y, et al. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med Genet. 2011;12:52 pubmed publisher
    Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity...
  22. Liu G, Zhu H, Dong Y, Podolsky R, Treiber F, Snieder H. Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur J Epidemiol. 2011;26:463-73 pubmed publisher
    Recent genome-wide association (GWA) studies identified several common variants for obesity: rs9939609 in FTO, rs7566605 near INSIG2 and both rs17782313 and rs17700633 near the MC4R gene...
  23. Elks C, Loos R, Sharp S, Langenberg C, Ring S, Timpson N, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med. 2010;7:e1000284 pubmed publisher
    ..Eight variants that showed individual associations with childhood BMI (in/near: FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, and ETV5) were used to derive an "obesity-risk-allele score" ..
  24. Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes. 2011;60:258-68 pubmed publisher
    A strong association between genetic variants and obesity was found for the fat mass and obesity-associated gene (FTO)...
  25. Ortega Azorín C, Sorli J, Asensio E, Coltell O, Martinez Gonzalez M, Salas Salvado J, et al. Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol. 2012;11:137 pubmed publisher
    Although the fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial...
  26. Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes. 2010;59:3085-9 pubmed publisher
    ..rs7138803, rs1805081, rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese ..
  27. Elliott K, Chapman K, Day Williams A, Panoutsopoulou K, Southam L, Lindgren C, et al. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis. 2013;72:935-41 pubmed publisher
    ..in the arcOGEN GWAS was also associated with osteoarthritis in the independent dataset: rs12149832, within the FTO gene (combined p=2.3×10(-5)). As expected, this signal was attenuated when we adjusted for BMI...
  28. McCaffery J, Papandonatos G, Huggins G, Peter I, Kahn S, Knowler W, et al. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013;37:1545-52 pubmed publisher
    ..However, fat mass and obesity associated gene (FTO) rs3751812 predicted weight regain within DSE (1.56?kg per risk allele, P=0...
  29. Bauer F, Elbers C, Adan R, Loos R, Onland Moret N, Grobbee D, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90:951-9 pubmed publisher
    ..They were in or near to 6 loci: FTO, MC4R, KCTD15, MTCH2, NEGR1, and BDNF. Five SNPs were associated with dietary intake (P < 0...
  30. Liem E, Vonk J, Sauer P, van der Steege G, Oosterom E, Stolk R, et al. Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study. Am J Clin Nutr. 2010;91:321-8 pubmed publisher
    ..regression analyses to assess the influence of candidate single nucleotide polymorphisms near the INSIG2, in the FTO, and near the MC4R genes and repeated-measures analyses of available body mass index (BMI) and skinfold thickness ..
  31. Jowett J, Curran J, Johnson M, Carless M, Goring H, Dyer T, et al. Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes. 2010;59:726-32 pubmed publisher
    ..Variant rs8050136 lies within intron 1 of the FTO gene on chromosome 16 and marks a locus strongly associated with type 2 diabetes and obesity and widely replicated ..
  32. Kaakinen M, Läärä E, Pouta A, Hartikainen A, Laitinen J, Tammelin T, et al. Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol. 2010;172:653-65 pubmed publisher
    The association between variation in the fat mass and obesity-associated (FTO) gene and adulthood body mass index (BMI; weight (kg)/height (m)(2)) is well-replicated...
  33. Li M, Liu Y, Xu P, Ye M, Liu Y. [Association of the rs9939609 polymorphism of FTO gene with overweight or obesity in Hazakh children]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:678-81 pubmed publisher
    To study the association of rs9939609 polymorphism of the fat mass and obesity associated gene (FTO) with overweight or obesity in Hazakh children...
  34. Iles M, Law M, Stacey S, Han J, Fang S, Pfeiffer R, et al. A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet. 2013;45:428-32, 432e1 pubmed publisher
    ..This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from ..
  35. Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel C, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet. 2010;6:e1000916 pubmed publisher
    ..Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen ..
  36. Huang W, Sun Y, Sun J. Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. Endocrine. 2011;39:69-74 pubmed publisher
    Genetic variants of FTO and MC4R have been linked with obesity and T2DM in populations of Europeans...
  37. Mitchell J, Church T, Rankinen T, Earnest C, Sui X, Blair S. FTO genotype and the weight loss benefits of moderate intensity exercise. Obesity (Silver Spring). 2010;18:641-3 pubmed publisher
    The fat mass and obesity-associated (FTO) gene was genotyped for the participants in the Dose-Response to Exercise in postmenopausal Women (DREW) trial and analyses were performed to determine whether an FTO variant was associated with ..
  38. Attaoua R, Ait el Mkadem S, Lautier C, Kaouache S, Renard E, Brun J, et al. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. Diabetes Metab. 2009;35:476-83 pubmed publisher
    ..The objective of the present study was to investigate the genetic association of the fat-mass-and-obesity-associated (FTO) gene in obese women in the presence of the known influential role of the insulin receptor substrate 2 (IRS-2) gene...
  39. Zavattari P, Loche A, Pilia S, Ibba A, Moi L, Guzzetti C, et al. rs9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese children. Ann Hum Genet. 2011;75:648-54 pubmed publisher
    ..association of the intronic single nucleotide polymorphism (SNP) rs9939609 of the fat mass and obesity-associated (FTO) gene with obesity and with a number of obesity-related features...
  40. Zeggini E, Panoutsopoulou K, Southam L, Rayner N, Day Williams A, Lopes M, et al. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet. 2012;380:815-23 pubmed publisher
    ..One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight-a strong risk factor for osteoarthritis...
  41. Ibba A, Pilia S, Zavattari P, Loche A, Guzzetti C, Casini M, et al. The role of FTO genotype on eating behavior in obese Sardinian children and adolescents. J Pediatr Endocrinol Metab. 2013;26:539-44 pubmed publisher
    We aimed to study the influence of the fat mass and obesity-associated (FTO) gene on eating behavior in 412 obese Sardinian children and adolescents...
  42. Li T, Wu K, You L, Xing X, Wang P, Cui L, et al. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS ONE. 2013;8:e66250 pubmed publisher
    Fat mass and obesity-associated gene (FTO) has been associated with obesity, especially the common variant rs9939609...
  43. Wen J, Rönn T, Olsson A, Yang Z, Lu B, Du Y, et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS ONE. 2010;5:e9153 pubmed publisher
    ..61 (1.19-2.18) P = 2.3 * 10(-3). Only nominal phenotype associations were observed, notably for rs8050136 in FTO and fasting plasma glucose (P = 0.002), postprandial plasma glucose (P = 0...
  44. Benedict C, Jacobsson J, Rönnemaa E, Sällman Almén M, Brooks S, Schultes B, et al. The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men. Neurobiol Aging. 2011;32:1159.e1-5 pubmed publisher
    Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries...
  45. Almén M, Jacobsson J, Moschonis G, Benedict C, Chrousos G, Fredriksson R, et al. Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics. 2012;99:132-7 pubmed publisher
    Variants of the FTO gene show strong association with obesity, but the mechanisms behind this association remain unclear. We determined the genome wide DNA methylation profile in blood from 47 female preadolescents...
  46. Luczynski W, Zalewski G, Bossowski A. The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in Polish children. J Physiol Pharmacol. 2012;63:241-8 pubmed
    ..The fat mass and obesity-associated (FTO) gene has recently become one of the most extensively investigated genes associated with body mass...
  47. den Hoed M, Westerterp Plantenga M, Bouwman F, Mariman E, Westerterp K. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. Am J Clin Nutr. 2009;90:1426-32 pubmed publisher
    The common rs9939609 single nucleotide polymorphism (SNP) in the fat mass and obesity-associated (FTO) gene is associated with adiposity, possibly by affecting satiety responsiveness...
  48. Rutters F, Lemmens S, Born J, Bouwman F, Nieuwenhuizen A, Mariman E, et al. Genetic associations with acute stress-related changes in eating in the absence of hunger. Patient Educ Couns. 2010;79:367-71 pubmed publisher
    Acute psychological stress is associated with eating in the absence of hunger. To investigate if BclI and FTO polymorphisms are associated with eating in the absence of hunger as a result of acute psychological stress...
  49. Gonzalez J, González Carpio M, Hernández Sáez R, Serrano Vargas V, Torres Hidalgo G, Rubio Rodrigo M, et al. FTO risk haplotype among early onset and severe obesity cases in a population of western Spain. Obesity (Silver Spring). 2012;20:909-15 pubmed publisher
    Childhood and adult obesity have been widely associated with FTO genetic variability in different populations...
  50. Tabara Y, Osawa H, Guo H, Kawamoto R, Onuma H, Shimizu I, et al. Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study. Int J Obes (Lond). 2009;33:1243-8 pubmed publisher
    Susceptibility of fat mass and obesity-associated (FTO) gene polymorphisms to obesity has been reported in various populations. Polymorphisms in the melanocortin 4 receptor (MC4R) gene were recently explored as another susceptible locus...
  51. Bollepalli S, Dolan L, Deka R, Martin L. Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring). 2010;18:1959-63 pubmed publisher
    ..Specifically, variants of the fat mass and obesity associated (FTO) gene have been associated with obesity in populations of European descent...
  52. Jacobsson J, Almén M, Benedict C, Hedberg L, Michaelsson K, Brooks S, et al. Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly. PLoS ONE. 2011;6:e20158 pubmed publisher
    The rs9939609 single-nucleotide polymorphism (SNP) in the fat mass and obesity (FTO) gene has previously been associated with higher BMI levels in children and young adults. In contrast, this association was not found in elderly men...
  53. Peng S, Zhu Y, Xu F, Ren X, Li X, Lai M. FTO gene polymorphisms and obesity risk: a meta-analysis. BMC Med. 2011;9:71 pubmed publisher
    The pathogenesis of obesity is reportedly related to variations in the fat mass and an obesity-associated gene (FTO); however, as the number of reports increases, particularly with respect to varying ethnicities, there is a need to ..
  54. Chauhan G, Tabassum R, Mahajan A, Dwivedi O, Mahendran Y, Kaur I, et al. Common variants of FTO and the risk of obesity and type 2 diabetes in Indians. J Hum Genet. 2011;56:720-6 pubmed publisher
    Common variants of fat mass and obesity-associated gene (FTO, fat mass- and obesity-associated gene) have been shown to be associated with obesity and type 2 diabetes in population of European and non-European ethnicity...
  55. de Luis D, Aller R, Conde R, Izaola O, de la Fuente B, Sagrado M. Relation of the rs9939609 gene variant in FTO with metabolic syndrome in obese female patients. J Diabetes Complications. 2013;27:346-50 pubmed publisher
    Common polymorphisms of the fat mass and obesity associated gene (FTO) have been linked to obesity and diabetes mellitus type 2 in some populations...
  56. Liu G, Zhu H, Lagou V, Gutin B, Stallmann Jorgensen I, Treiber F, et al. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet. 2010;11:57 pubmed publisher
    Genome-wide association studies found common variants in the fat mass and obesity-associated (FTO) gene associated with adiposity in Caucasians and Asians but the association was not confirmed in African populations...
  57. Ahmad T, Chasman D, Mora S, Pare G, Cook N, Buring J, et al. The fat-mass and obesity-associated (FTO) gene, physical activity, and risk of incident cardiovascular events in white women. Am Heart J. 2010;160:1163-9 pubmed publisher
    Variation in the Fat-Mass and Obesity-Associated (FTO) gene has been associated with obesity, diabetes, and hypertension...
  58. Lear S, Deng W, Pare G, Sulistyoningrum D, Loos R, Devlin A. Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort. Genet Res (Camb). 2011;93:419-26 pubmed publisher
    The fat mass and obesity associated (FTO) gene has been implicated with obesity and dietary intake predominantly in European populations...
  59. Okada Y, Kubo M, Ohmiya H, Takahashi A, Kumasaka N, Hosono N, et al. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. Nat Genet. 2012;44:302-6 pubmed publisher
    ..3 × 10(-9)), as well as several previously reported loci (the SEC16B, BDNF, FTO, MC4R and GIPR loci, P < 5.0 × 10(-8))...
  60. Smemo S, Tena J, Kim K, Gamazon E, Sakabe N, G mez Mar n C, et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature. 2014;507:371-5 pubmed publisher
    Genome-wide association studies (GWAS) have reproducibly associated variants within introns of FTO with increased risk for obesity and type 2 diabetes (T2D)...
  61. Binh T, Phuong P, Nhung B, Thoang D, Lien H, Thanh D. Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population. Gene. 2013;513:31-5 pubmed publisher
    ..to investigate whether the association between T2D and the common T>A polymorphism (rs9939609) in fat mass and obesity associated (FTO) gene is mediated by obesity-related measurements, considering the contribution of socio-..
  62. Graff M, Ngwa J, Workalemahu T, Homuth G, Schipf S, Teumer A, et al. Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course. Hum Mol Genet. 2013;22:3597-607 pubmed publisher
    ..We identified seven independent loci (P < 5.0 × 10??) near FTO (P = 3.72 × 10?²³), TMEM18 (P = 3.24 × 10?¹?), MC4R (P = 4.41 × 10?¹?), TNNI3K (P = 4...
  63. Sonestedt E, Gullberg B, Ericson U, Wirfalt E, Hedblad B, Orho Melander M. Association between fat intake, physical activity and mortality depending on genetic variation in FTO. Int J Obes (Lond). 2011;35:1041-9 pubmed publisher
    We wanted to explore if FTO genotype interacts with fat intake, or leisure-time physical activity, on fat mass, lean mass and mortality...
  64. Hassanein M, Lyon H, Nguyen T, Akylbekova E, Waters K, Lettre G, et al. Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet. 2010;19:2907-16 pubmed publisher
    ..replicate and fine map in populations of predominantly African ancestry the association between variation at the FTO locus and body mass index (BMI) that is well established in populations of European ancestry...
  65. Zimmermann E, Skogstrand K, Hougaard D, Astrup A, Hansen T, Pedersen O, et al. Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index. PLoS ONE. 2011;6:e15958 pubmed publisher
    A recent study reported that the fatness associated A-allele of FTO rs9939609 increased plasma high sensitivity C-reactive protein (hs-CRP) levels independent of fatness...
  66. Li H, Kilpeläinen T, Liu C, Zhu J, Liu Y, Hu C, et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia. 2012;55:981-95 pubmed publisher
    b>FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent...
  67. Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS ONE. 2009;4:e7643 pubmed publisher
    ..406 (P value range from 0.0335 to 1.37E-12). But no significant association was detected between SNPs from WFS1, FTO, JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30 and type 2 diabetes...
  68. Karasawa S, Daimon M, Sasaki S, Toriyama S, Oizumi T, Susa S, et al. Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocr J. 2010;57:293-301 pubmed
    The association of the FTO gene polymorphism, rs9939609, with obesity was examined using the population of the Takahata study (n (M/F): 2,639 (1,168 / 1,470); age: 63.0 +/- 10.2 years), a Japanese community-based study...
  69. Rendo T, Moleres A, Marti Del Moral A. Effects of the FTO gene on lifestyle intervention studies in children. Obes Facts. 2009;2:393-9 pubmed publisher
    The effects of FTO on body weight, body composition, and the risk of developing overweight and obesity in children, adolescents, and adults are analyzed in this review. Most trails have been conducted on the rs9939609 SNP of the FTO gene...
  70. Xi B, Zhang M, Shen Y, Zhao X, Wang X, Mi J. [Impact on the risk of obesity due to interactions between fat mass- and obesity-associated gene rs9939609 variants and behavioral factors, in the Chinese school-aged children]. Zhonghua Liu Xing Bing Xue Za Zhi. 2010;31:737-41 pubmed
    To investigate how the interactions between fat mass- and obesity-associated (FTO) gene rs9939609 variants and daily-life related behavioral factors would influence the risk of obesity among the Chinese school-aged children...
  71. Cecil J, Dalton M, Finlayson G, Blundell J, Hetherington M, Palmer C. Obesity and eating behaviour in children and adolescents: contribution of common gene polymorphisms. Int Rev Psychiatry. 2012;24:200-10 pubmed publisher
    ..Investigations of robustly characterized common gene variants of fat mass and obesity associated (FTO), peroxisome proliferator-activated receptor (PPARG) and melanocortin 4 receptor (MC4R) which ..
  72. Berulava T, Ziehe M, Klein Hitpass L, Mladenov E, Thomale J, Ruther U, et al. FTO levels affect RNA modification and the transcriptome. Eur J Hum Genet. 2013;21:317-23 pubmed publisher
    A block of single-nucleotide polymorphisms within intron 1 of the FTO (fat mass and obesity associated) gene is associated with variation in body weight...
  73. Meyre D, Proulx K, Kawagoe Takaki H, Vatin V, Gutiérrez Aguilar R, Lyon D, et al. Prevalence of loss-of-function FTO mutations in lean and obese individuals. Diabetes. 2010;59:311-8 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in intron 1 of fat mass- and obesity-associated gene (FTO) are strongly associated with human adiposity, whereas Fto(-/-) mice are lean and Fto(+/-) mice are resistant to diet-induced obesity...
  74. Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, Lobbens S, et al. Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 show evidence of association with adult obesity in the Greek population. Obesity (Silver Spring). 2012;20:389-95 pubmed publisher
    ..We nominally replicated the association with obesity (BMI ?30 kg/m(2)) of six SNPs in or near the FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 loci (1.28 ? odds ratio (OR) ? 1.35; 0.004 ? P ? 0.043)...
  75. Dougkas A, Yaqoob P, Givens D, Reynolds C, Minihane A. The impact of obesity-related SNP on appetite and energy intake. Br J Nutr. 2013;110:1151-6 pubmed publisher
    ..Individuals were genotyped for SNP in the fat mass and obesity-associated (FTO), leptin (LEP), leptin receptor (LEPR) genes and a variant near the melanocortin-4 receptor (MC4R) locus...
  76. Shi J, Long J, Gao Y, Lu W, Cai Q, Wen W, et al. Evaluation of genetic susceptibility loci for obesity in Chinese women. Am J Epidemiol. 2010;172:244-54 pubmed publisher
    ..Two SNPs near the BAT2 and MC4R genes and 3 SNPs within the FTO, SEC16B, and SH2B1 genes were significantly associated with body mass index (weight (kg)/height (m)(2)), body ..
  77. Wang T, Huang Y, Xiao X, Wang D, Diao C, Zhang F, et al. The association between common genetic variation in the FTO gene and metabolic syndrome in Han Chinese. Chin Med J (Engl). 2010;123:1852-8 pubmed
    Genome-wide association studies for type 2 diabetes mellitus (T2DM) identified FTO gene as a locus conferring increased risk for common obesity in many populations with European ancestry...
  78. Russo P, Lauria F, Siani A. Heritability of body weight: moving beyond genetics. Nutr Metab Cardiovasc Dis. 2010;20:691-7 pubmed publisher
    ..However, the population attributable risk for obesity linked to the most statistically significant loci, like FTO and MC4R, remains discouragingly low, explaining only small fractions of the overall variance of body weight...
  79. Hallman D, Friedel V, Eissa M, Boerwinkle E, Huber J, Harrist R, et al. The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents. Int J Obes (Lond). 2012;36:61-8 pubmed publisher
    ..possible age-related changes in associations between polymorphisms in the fat mass and obesity-associated (FTO) gene and higher body mass index (BMI)...
  80. Xi B, Zhang M, Wang C, Shen Y, Zhao X, Wang X, et al. The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children. Mol Biol Rep. 2013;40:773-8 pubmed publisher
    Previous studies have suggested that common variants in fat mass- and obesity-associated (FTO) gene are associated with body mass index (BMI) and the risk of obesity...
  81. Bravard A, Veilleux A, Disse E, Laville M, Vidal H, Tchernof A, et al. The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity. Obesity (Silver Spring). 2013;21:1165-73 pubmed publisher
    The fat mass and obesity associated (FTO) gene is related to obesity, but the regulation of FTO expression in adipose tissue is not fully understood...
  82. Jacobsson J, Riserus U, Axelsson T, Lannfelt L, Schioth H, Fredriksson R. The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. BMC Med Genet. 2009;10:131 pubmed publisher
    Common FTO (fat mass and obesity associated) gene variants have recently been strongly associated with body mass index and obesity in several large studies...
  83. Terra X, Auguet T, Porras J, Quintero Y, Aguilar C, Luna A, et al. Anti-inflammatory profile of FTO gene expression in adipose tissues from morbidly obese women. Cell Physiol Biochem. 2010;26:1041-50 pubmed publisher
    The fat mass and obesity associated (FTO) gene has been found to contribute to the risk of obesity in humans, but the function and regulation of FTO mRNA expression in adipose tissues remain to be clarified...
  84. Winter Y, Back T, Scherag A, Linseisen J, Rohrmann S, Lanczik O, et al. Evaluation of the obesity genes FTO and MC4R and the type 2 diabetes mellitus gene TCF7L2 for contribution to stroke risk: The Mannheim-Heidelberg Stroke Study. Obes Facts. 2011;4:290-6 pubmed publisher
    ..The objective was to investigate the genetic markers related to obesity genes FTO and MC4R and the gene of type 2 diabetes mellitus TCF7L2 for their contribution to risk of stroke and transient ..