FTH1

Summary

Gene Symbol: FTH1
Description: ferritin, heavy polypeptide 1
Alias: FHC, FTH, FTHL6, HFE5, PIG15, PLIF, apoferritin, cell proliferation-inducing gene 15 protein, ferritin H subunit, ferritin heavy chain, placenta immunoregulatory factor, proliferation-inducing protein 15
Species: human

Top Publications

  1. pmc Binding and uptake of H-ferritin are mediated by human transferrin receptor-1
    Li Li
    Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 107:3505-10. 2010
  2. pmc Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
    Simon Swingler
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, MA 01605, USA
    Cell Host Microbe 4:63-76. 2008
  3. pmc mu-1,2-Peroxobridged di-iron(III) dimer formation in human H-chain ferritin
    Fadi Bou-Abdallah
    Department of Chemistry, University of New Hampshire, Durham, NH 03824, USA
    Biochem J 364:57-63. 2002
  4. ncbi A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Blood Cells Mol Dis 27:783-802. 2001
  5. ncbi Epidural abscess and discitis complicating instrumented posterior lumbar interbody fusion: a case report
    Jonathan J Carmouche
    University of Rochester School of Medicine and Dentistry, Department of Orthopaedic Surgery, Spine Division, Rochester, New York, USA
    Spine (Phila Pa 1976) 29:E542-6. 2004
  6. doi Dose-dependent inhibition of diclofenac sodium on posterior lumbar interbody fusion rates
    Jose Miguel T Lumawig
    Department of Orthopedics, Philippine General Hospital, Taft Avenue, Manila, Philippines
    Spine J 9:343-9. 2009
  7. ncbi Segmental stability and compressive strength of posterior lumbar interbody fusion implants
    A Tsantrizos
    Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 25:1899-907. 2000
  8. ncbi Induction of ferritin synthesis in cells infected with Mengo virus
    M R Mulvey
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 271:9851-7. 1996
  9. pmc Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease
    Neil V Morgan
    Wellchild Paediatric Research Centre and Department of Medical and Molecular Genetics, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom
    PLoS Genet 6:e1000833. 2010
  10. doi Effects of ascorbic acid, phytic acid and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model
    Fuxia Jin
    USDA ARS, The Robert W Holley Center for Health and Agriculture, Tower Road, Ithaca, New York 14853, USA
    Br J Nutr 101:972-81. 2009

Detail Information

Publications227 found, 100 shown here

  1. pmc Binding and uptake of H-ferritin are mediated by human transferrin receptor-1
    Li Li
    Department of Medicine, Veterans Administration Medical Center, San Francisco, CA 94121, USA
    Proc Natl Acad Sci U S A 107:3505-10. 2010
    Ferritin is a spherical molecule composed of 24 subunits of two types, ferritin H chain (FHC) and ferritin L chain (FLC)...
  2. pmc Evidence for a pathogenic determinant in HIV-1 Nef involved in B cell dysfunction in HIV/AIDS
    Simon Swingler
    University of Massachusetts Medical School, Program in Molecular Medicine, 373 Plantation Street, Worcester, MA 01605, USA
    Cell Host Microbe 4:63-76. 2008
    ..Collectively, these results indicate that the HIV-1 Nef protein carries a pathogenic determinant that governs B cell defects in HIV-1 infection...
  3. pmc mu-1,2-Peroxobridged di-iron(III) dimer formation in human H-chain ferritin
    Fadi Bou-Abdallah
    Department of Chemistry, University of New Hampshire, Durham, NH 03824, USA
    Biochem J 364:57-63. 2002
    ....
  4. ncbi A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Blood Cells Mol Dis 27:783-802. 2001
    ..These were further examined for association with differences in iron accumulation as measured by plasma transferrin saturation and ferritin levels, but no such association could be documented...
  5. ncbi Epidural abscess and discitis complicating instrumented posterior lumbar interbody fusion: a case report
    Jonathan J Carmouche
    University of Rochester School of Medicine and Dentistry, Department of Orthopaedic Surgery, Spine Division, Rochester, New York, USA
    Spine (Phila Pa 1976) 29:E542-6. 2004
    A case of epidural abscess and discitis following instrumented PLIF using a single carbon fiber interbody cage is presented.
  6. doi Dose-dependent inhibition of diclofenac sodium on posterior lumbar interbody fusion rates
    Jose Miguel T Lumawig
    Department of Orthopedics, Philippine General Hospital, Taft Avenue, Manila, Philippines
    Spine J 9:343-9. 2009
    ..It is very popular as a first-line treatment for acute pain, even perioperatively for spine fusion patients. Review of published literature reveals no studies done on the effect of diclofenac sodium on spine fusion rates...
  7. ncbi Segmental stability and compressive strength of posterior lumbar interbody fusion implants
    A Tsantrizos
    Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 25:1899-907. 2000
    ..Three posterior lumbar interbody fusion implant constructs (Ray Threaded Fusion Cage, Contact Fusion Cage, and PLIF Allograft Spacer) were tested nondestructively in axial rotation, flexion-extension, and lateral bending...
  8. ncbi Induction of ferritin synthesis in cells infected with Mengo virus
    M R Mulvey
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 271:9851-7. 1996
    ..from infected murine L929 cells showed a 4- and 6-fold increase in the intracellular concentrations of H and L apoferritin subunits, respectively. This differential expression altered the H/L subunit ratio from 3...
  9. pmc Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease
    Neil V Morgan
    Wellchild Paediatric Research Centre and Department of Medical and Molecular Genetics, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom
    PLoS Genet 6:e1000833. 2010
    ..In most cases the pathophysiology is unclear and treatment is nonspecific. Faisalabad histiocytosis (FHC) (MIM 602782) has been classed as an autosomal recessively inherited form of histiocytosis with similarities to ..
  10. doi Effects of ascorbic acid, phytic acid and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model
    Fuxia Jin
    USDA ARS, The Robert W Holley Center for Health and Agriculture, Tower Road, Ithaca, New York 14853, USA
    Br J Nutr 101:972-81. 2009
    ..Horse spleen apoferritin was chemically reconstituted into an animal-type ferritin (HSF) and a plant-type ferritin (P-HSF) according to ..
  11. pmc Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice
    Theodore P Abraham
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Cardiovasc Res 82:84-92. 2009
    ..the ventricular myosin regulatory light chain (RLC) were identified to cause familial hypertrophic cardiomyopathy (FHC)...
  12. ncbi Outcome of clinical versus genetic family screening in hypertrophic cardiomyopathy with focus on cardiac beta-myosin gene mutations
    Ole Havndrup
    Department of Medicine B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cardiovasc Res 57:347-57. 2003
    Familial hypertrophic cardiomyopathy (FHC) is caused by mutations in genes encoding cardiac sarcomere proteins. Although available, genetic analyses are generally not used clinically...
  13. ncbi [Adjacent segment degeneration after lumbosacral fusion in spondylolisthesis: a retrospective radiological and clinical analysis]
    P Zencica
    Ortopedická klinika FN Brno Bohunice
    Acta Chir Orthop Traumatol Cech 77:124-30. 2010
    Whereas the posterior lumbar interbody fusion (PLIF) technique with pedicle screw fixation has shown satisfactory clinical results, solid fusion has been reported to accelerate degenerative changes at adjacent unfused levels, especially ..
  14. ncbi Risk factors for adjacent segment degeneration after PLIF
    Shin ya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    Spine (Phila Pa 1976) 29:1535-40. 2004
    A retrospective study of 87 patients who underwent posterior lumbar interbody fusion (PLIF) at L4-L5 for L4 degenerative spondylolisthesis.
  15. ncbi A novel missense mutation, Leu390Val, in the cardiac beta-myosin heavy chain associated with pronounced septal hypertrophy in two families with hypertrophic cardiomyopathy
    O Havndrup
    Department of Medicine B, The Heart Center, Rigshospitalet, University of Copenhagen, Denmark
    Scand Cardiovasc J 34:558-63. 2000
    An examination of the genetic background and phenotypic presentation of familial hypertrophic cardiomyopathy (FHC) with respect to specific mutations in the MYH7-gene encoding the cardiac beta-myosin heavy chain.
  16. ncbi QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice
    L M Bevilacqua
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatr Res 45:643-7. 1999
    Patients with familial hypertrophic cardiomyopathy (FHC) are at risk for ventricular arrhythmias and sudden death...
  17. ncbi Posterior lumbar interbody fusion with facet-screw fixation
    T Stonecipher
    Everett Clinic, Everett, WA 98201
    Spine (Phila Pa 1976) 14:468-71. 1989
    The optimal surgical construct for lumbar fusion remains controversial. The posterior lumbar interbody fusion (PLIF) operation offers advantages including total nuclear disc excision, restoration of disc-space height, root decompression, ..
  18. doi Sex life and sexual function in men and women before and after total disc replacement compared with posterior lumbar fusion
    Svante Berg
    Stockholm Spine Center, Löwenströmska Hospital, SE 19489, Upplands Vasby, Stockholm, Sweden
    Spine J 9:987-94. 2009
    ..This has led to concern as to whether anterior surgery should be employed in men, at least in younger age groups...
  19. ncbi Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury
    R F Regan
    Department of Surgery, Thomas Jefferson University, 1020 Sansom Street, 239 Thompson Building, Philadelphia, PA 19107, USA
    Neuroscience 113:985-94. 2002
    ..An enhanced ferritin band was detected on immunoblots from cultures that were treated with purified apoferritin, consistent with astrocytic ferritin uptake...
  20. ncbi Two pathways of iron uptake in bovine spleen apoferritin dependent on iron concentration
    Koichi Orino
    Laboratory of Biochemistry, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Biometals 15:59-63. 2002
    Iron incorporation by bovine spleen apoferritin either with ferrous ammonium sulfate in different buffers or with ferrous ammonium sulfate and phosphate was studied. Iron uptake and iron autoxidation were recorded spectrophotomerically...
  21. doi Volatile anesthetic binding to proteins is influenced by solvent and aliphatic residues
    John H Streiff
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294 1150, USA
    J Chem Inf Model 48:2066-73. 2008
    ..that exceeded minimum values observed in the VA binding sites of serum albumin, firefly luciferase, and apoferritin. We found that the structures of VA binding proteins are enriched in these pockets and that the predicted ..
  22. ncbi Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties
    Dagmar I Keller
    INSERM U582, Institut de Myologie, , , 47, , 75651 Paris Cedex 13, France
    J Mol Cell Cardiol 36:355-62. 2004
    Familial hypertrophic cardiomyopathy (FHC) is associated with mutations in 11 genes encoding sarcomeric proteins. Most families present mutations in MYBPC3 and MYH7 encoding cardiac myosin-binding protein C and beta-myosin heavy chain...
  23. ncbi Posterior lumbar interbody fusion using posterolateral placement of a single cylindrical threaded cage
    J Zhao
    Department of Orthopedic Surgery, Changhai Hospital, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 25:425-30. 2000
    STUDY DESIGN: An in vitro biomechanical study of posterior lumbar interbody fusion (PLIF) with threaded cages was performed on 18 bovine lumbar functional spinal units...
  24. ncbi Social protection in Brazil: universalism and targeting in the FHC and Lula administrations
    Nilson do Rosário Costa
    Departamento de Ciências Sociais, Escola Nacional de Saude Publica, FIOCRUZ, Rio de Janeiro, RJ, 21045 210, Brazil
    Cien Saude Colet 14:693-706. 2009
    ..Targeting is an innovation directly associated with the adjustment agenda. It reveals that under the FHC and Lula administrations there was an identical adoption of targeted social programs...
  25. pmc Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:20579-89. 2008
    ..in the beta-myosin heavy chain (MHC) was the first mutation to be linked to familial hypertrophic cardiomyopathy (FHC), a primary disease of heart muscle...
  26. pmc Fluorescence lifetime of actin in the familial hypertrophic cardiomyopathy transgenic heart
    P Mettikolla
    Department of Molecular Biology and Immunology and Center for Commercialization of Fluorescence Technologies, University of North Texas, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, USA
    Biochemistry 48:1264-71. 2009
    ..myosin regulatory light chain (RLC) can cause a malignant phenotype of familial hypertrophic cardiomyopathy (FHC)...
  27. ncbi Scavenger receptors facilitate protein transport in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes)
    Joachim F Schindler
    Institut fur Anatomie, Universitat Regensburg, Regensburg, Germany
    J Exp Zool A Comp Exp Biol 299:197-212. 2003
    ..Binding to TACs of NF was completely inhibitable by proteins containing multiple lysine residues such as apoferritin, bovine serum albumin (BSA), human transferrin (HTf), fetuin, hemoglobin, myoglobin, cytochrome c, ubiquitin, ..
  28. ncbi Cage migration in spondylolisthesis treated with posterior lumbar interbody fusion using BAK cages
    Liang Chen
    Department of Orthopaedic Surgery, First Affiliated Hospital of Suzhou University, Suzhou, PRC
    Spine (Phila Pa 1976) 30:2171-5. 2005
    A retrospective study was conducted to review the complication of cage migration in posterior lumbar interbody fusion (PLIF) with the Bagby and Kuslich method.
  29. ncbi Comparative architecture of silks, fibrous proteins and their encoding genes in insects and spiders
    Catherine L Craig
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    Comp Biochem Physiol B Biochem Mol Biol 133:493-507. 2002
    ..All of the sequenced fibroin silks (Flag or silk from flagelliform gland in spiders; Fhc or heavy chain fibroin silks produced by Lepidoptera larvae) are made up of hierarchically organized, repetitive ..
  30. pmc Comparative study of PILF and TLIF treatment in adult degenerative spondylolisthesis
    Deng Lu Yan
    Orthopedic Department, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, Peoples Republic of China
    Eur Spine J 17:1311-6. 2008
    This study is to compare the therapeutic effect of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) with pedicle screw fixation on treatment in adult degenerative spondylolisthesis...
  31. ncbi Residual sagittal motion after lumbar fusion: a finite element analysis with implications on radiographic flexion-extension criteria
    Christopher M Bono
    Boston University School of Medicine, Department of Orthopaedic Surgery, Boston, MA, USA
    Spine (Phila Pa 1976) 32:417-22. 2007
    ..Finite element analysis of a lumbar fusion model...
  32. ncbi PLIF with a titanium cage and excised facet joint bone for degenerative spondylolisthesis--in augmentation with a pedicle screw
    Koichiro Okuyama
    Department of Orthopedic Surgery, Akita Rosai Hospital, Akita 018 5604, Japan
    J Spinal Disord Tech 20:53-9. 2007
    To determine the validity of posterior lumbar interbody fusion (PLIF) using a titanium cage filled with excised facet joint bone and a pedicle screw for degenerative spondylolisthesis.
  33. ncbi Low-grade isthmic spondylolisthesis treated with instrumented posterior lumbar interbody fusion in U.S. servicemen
    Robert W Molinari
    Department of Orthopaedic Surgery, University of Rochester Spine Center, Rochester, New York, USA
    J Spinal Disord Tech 18:S24-9. 2005
    ..The purpose was to evaluate patient-assessed function/pain/satisfaction and military job performance in U.S. servicemen treated with posterior lumbar interbody fusion (PLIF).
  34. ncbi Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks
    Chaya Moroz
    Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel
    Exp Hematol 34:159-66. 2006
    Placenta immunomodulator ferritin (PLIF) is a cloned human chimeric ferritin H chain with a novel non-ferritin C-terminal 48 amino acid sequence (C48). Recombinant PLIF-C48 exhibited cell-mediated immunosuppression...
  35. ncbi [Clinical classification and surgical options of the far-lateral lumbar disc herniation]
    Fang Li
    Institute of Traumatology and Orthopedics, General Hospital of Beijing Military Command, Beijing 100700, China
    Zhonghua Wai Ke Za Zhi 47:1553-6. 2009
    ..To suggest the clinical classification of the far-lateral lumbar disc herniation and offer the considerations for clinical choice of different surgical procedures...
  36. pmc Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase
    Syevda G Sirenko
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
    J Physiol 575:201-13. 2006
    Troponin T (TnT) mutations that cause familial hypertrophic cardiomyopathy (FHC) and sudden cardiac death frequently increase myofilament Ca2+ sensitivity, suggesting that their Ca2+-sensitizing effect contributes importantly to the FHC ..
  37. ncbi Posterior lumbar interbody fusion for degenerative spondylolisthesis: restoration of sagittal balance using insert-and-rotate interbody spacers
    William Sears
    Department of Neurosurgery, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW 2065, Australia
    Spine J 5:170-9. 2005
    ..The insert-and-rotate posterior lumbar interbody fusion (PLIF) technique, first described by Jaslow in 1946, may enable surgeons to safely and effectively correct sagittal ..
  38. ncbi Lumbar trapezoid plate for lumbar spondylolisthesis. A clinical study on preoperative and postoperative instability
    Y Kamioka
    Orthopedic Department, Sanraku Hospital, Japan
    Spine (Phila Pa 1976) 15:1198-203. 1990
    ..For this purpose, it is considered important to prevent grafted bones of the posterior lumbar interbody fusion (PLIF) from collapse and to maintain the achieved alignment of the lumbar spine.
  39. doi Radiological comparison of instrumented posterior lumbar interbody fusion with one or two closed-box plasmapore coated titanium cages: follow-up study over more than seven years
    Stefan Kroppenstedt
    Universitätsklinikum Charité Campus Virchow Klinikum, Augustenburger Platz, Berlin, Germany
    Spine (Phila Pa 1976) 33:2083-8. 2008
    ..A retrospective clinical study with a follow-up of more than 7 years was conducted...
  40. ncbi Posterior lumbar interbody fusion versus posterolateral fusion in adult isthmic spondylolisthesis
    Per Ekman
    Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden
    Spine (Phila Pa 1976) 32:2178-83. 2007
    ..A prospective study with historical controls...
  41. ncbi Achievement of normal sagittal plane alignment using a wedged carbon fiber reinforced polymer fusion cage in treatment of spondylolisthesis
    John W Brantigan
    South Texas Orthopaedic and Spinal Surgery Associates, 9150 Huebner Road, San Antonio, TX 78240, USA
    Spine J 3:186-96. 2003
    ..A wedged-shaped carbon-fiber-reinforced polymer (CFRP) cage implant filled with autologous bone was designed to allow surgeons to more easily achieve normal sagittal plane alignment in posterior lumbar interbody fusion (PLIF).
  42. ncbi Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapy of cancers
    Hong Wu
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Nanosci Nanotechnol 8:2316-22. 2008
    We report a templated-synthetic approach based on protein-cage of apoferritin to prepare radionuclide nanoparticle (NP) conjugates...
  43. pmc Evaluation of a recombinant Hc of Clostridium botulinum neurotoxin serotype F as an effective subunit vaccine
    Yun Zhou Yu
    Beijing Institute of Biotechnology, 20 Dongdajie St, Fengtai District, Beijing 100071, China
    Clin Vaccine Immunol 15:1819-23. 2008
    A new gene encoding the Hc domain of Clostridium botulinum neurotoxin serotype F (FHc) was designed and completely synthesized with oligonucleotides. A soluble recombinant Hc of C...
  44. doi [Corticosteroid therapy and secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis and idiopathic chronic anterior uveitis]
    C Heinz
    Augenabteilung, St Franziskus Hospital, Munster, Germany
    Klin Monbl Augenheilkd 227:413-7. 2010
    ..This study examines the influence of corticosteroid therapy on the incidence of secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis (FHC) and chronic anterior uveitis.
  45. ncbi Immune complex glomerulonephritis in C4- and C3-deficient mice
    R J Quigg
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Kidney Int 53:320-30. 1998
    ..glomerulonephritis by actively immunizing C4-deficient (C4 -/-), C3 deficient (C3 -/-) and wild-type mice with apoferritin. Wild-type animals with an intact complement system produced anti-apoferritin IgG and IgM antibodies, and ..
  46. ncbi Outcome of one-level posterior lumbar interbody fusion for spondylolisthesis and postoperative intervertebral disc degeneration adjacent to the fusion
    N Miyakoshi
    Department of Orthopedic Surgery, Akita University School of Medicine, Akita Japan miyakoshodoc med akita u ac jp
    Spine (Phila Pa 1976) 25:1837-42. 2000
    ..of the clinical and radiologic records of patients who underwent one-level posterior lumbar interbody fusion (PLIF) at L4-L5...
  47. ncbi Iron(III) complexation of Desferrioxamine B encapsulated in apoferritin
    José M Domínguez-Vera
    Departamento de Quimica Inorganica, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain
    J Inorg Biochem 98:469-72. 2004
    The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7...
  48. pmc Familial hypertrophic cardiomyopathy. Microsatellite haplotyping and identification of a hot spot for mutations in the beta-myosin heavy chain gene
    E Dausse
    Institut National de la Sante et de la Recherche Medicale, U127, Hopital Lariboisiere, Paris, France
    J Clin Invest 92:2807-13. 1993
    Familial hypertrophic cardiomyopathy (FHC) is a clinically and genetically heterogeneous disease. The first identified disease gene, located on chromosome 14q11-q12, encodes the beta-myosin heavy chain...
  49. ncbi Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils
    Bogdan Iorga
    Institute of Vegetative Physiology, University of Cologne, Robert Koch Strasse 39, Cologne, Germany
    Cardiovasc Res 77:676-86. 2008
    ..the functional consequences of the Lys184 deletion in murine cardiac troponin I (mcTnI(DeltaK184)), we have studied the primary effects of this mutation linked to familial hypertrophic cardiomyopathy (FHC) at the sarcomeric level.
  50. ncbi Surgical complications of posterior lumbar interbody fusion with total facetectomy in 251 patients
    Shinya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 4:304-9. 2006
    Previous studies of surgical complications associated with posterior lumbar interbody fusion (PLIF) are of limited value due to intrastudy variation in instrumentation and fusion techniques...
  51. ncbi Problems of posterior lumbar interbody fusion (PLIF) for the rheumatoid spondylitis of the lumbar spine
    Masahiro Inaoka
    Department of Orthopaedic Surgery, Nissay Hospital, 3 8, Itachibori 6 chome, Nishi ku, Osaka 550 0012, Japan
    Arch Orthop Trauma Surg 122:73-9. 2002
    We performed posterior lumbar interbody fusion (PLIF) on 7 patients with rheumatoid spondylitis (RA) of the lumbar spine with severe low-back pain and/or cauda equina symptoms, and evaluated the effectiveness of PLIF for the lumbar spinal ..
  52. ncbi Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C
    M Gruen
    Max Planck Institut fur molekulare Physiologie, Rheinlanddamm 201, Dortmund, 44139, Germany
    J Mol Biol 286:933-49. 1999
    ..In this region, several mutations in beta-myosin are associated with FHC; however, their molecular implications remained unclear...
  53. pmc Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
    Giulia Mearini
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Cardiovasc Res 85:357-66. 2010
    Familial hypertrophic cardiomyopathy (FHC) is frequently caused by cardiac myosin-binding protein C (cMyBP-C) gene mutations, which should result in C-terminal truncated mutants...
  54. ncbi A carbon fiber implant to aid interbody lumbar fusion. Two-year clinical results in the first 26 patients
    J W Brantigan
    Department of Surgery, Division of Orthopaedics, Creighton University, Omaha, Nebraska
    Spine (Phila Pa 1976) 18:2106-7. 1993
    The success of posterior lumbar interbody fusion (PLIF) has been limited by mechanical and biologic deficiencies of the donor bone...
  55. doi Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
    William E Dowdle
    Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Cell Biol 16:1069-79. 2014
    ..NCOA4 directly binds ferritin heavy chain-1 (FTH1) to target the iron-binding ferritin complex with a relative molecular mass of 450,000 to ..
  56. ncbi [PLIF and ALIF for the degenerative spondylolisthesis of the lumbar spine]
    J Lemcke
    Klinik für Neurochirurgie, Unfallkrankenhaus Berlin, Germany
    Z Orthop Ihre Grenzgeb 145:48-54. 2007
    The aim of this study is to compare the course of disease of patients with a degenerative instability of the lumbar spine after PLIF or ALIF.
  57. doi Consideration of family history of cancer in medical routine: a survey in the primary care setting in Germany
    Jonas Fiederling
    aCancer Registry Baden Württemberg, German Cancer Research Center DKFZ bDivision of Preventive Oncology, National Center for Tumor Diseases NCT German Cancer Research Center DKFZ cDivision of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Cancer Prev 23:199-205. 2014
    Family history of cancer (FHC) is important in the context of cancer prevention and risk counselling, but there is a lack of information about its consideration in medical routine...
  58. ncbi Nitinol spring rod dynamic stabilization system and Nitinol memory loops in surgical treatment for lumbar disc disorders: short-term follow up
    Young Soo Kim
    Department of Neurosurgery, Kwang Hye Spine Hospital, Seoul, Korea
    Neurosurg Focus 22:E10. 2007
    ....
  59. doi The effect of interventions based on the programs of The Institutes for the Achievement of Human Potential and Family Hope Center
    Stephen von Tetzchner
    Department of Psychology, University of Oslo, Oslo, Norway
    Dev Neurorehabil 16:217-29. 2013
    To compare the effect of the programs of IAHP and FHC with ordinary community-based programs.
  60. ncbi The response of benthic foraminifera to various pollution sources: a study from Nellore Coast, East Coast of India
    N Jayaraju
    Department of Geology, Sri Venkateswara University, Tirupati 517 502, India
    Environ Monit Assess 142:319-23. 2008
    ..foraminifera that minimal species number (4-7) can currently preserved in living condition in a depth less than 5-fth contour from coast...
  61. ncbi Use of layer silicate for protein crystallization: effects of Micromica and chlorite powders in hanging drops
    Masahide Takehara
    Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Anal Biochem 373:322-9. 2008
    ..Except for threonine synthase and apoferritin, the presence of chlorite delayed crystallization but induced the formation of large crystals...
  62. pmc Temporal and morphological impact of pressure overload in transgenic FHC mice
    Hao Chen
    Molecular Cardiovascular Research Program, Department of Physiology, University of Arizona Tucson, AZ, USA
    Front Physiol 4:205. 2013
    Although familial hypertrophic cardiomyopathy (FHC) is characterized as cardiac disease in the absence of overt stressors, disease penetrance, and pathological progression largely depend on modifying factors...
  63. doi Regulation of microRNA-1288 in colorectal cancer: altered expression and its clinicopathological significance
    Vinod Gopalan
    Cancer Molecular Pathology of Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia
    Mol Carcinog 53:E36-44. 2014
    ..Two colon cancer cell lines (SW480 and SW48) and one normal colonic epithelial cell line (FHC) were recruited...
  64. ncbi [Finite element analysis of lumbar fusion and Topping-off surgery]
    Hai Ying Liu
    Department of Spinal Surgery, Peking University People s Hospital, Beijing 100044, China
    Beijing Da Xue Xue Bao 45:723-7. 2013
    To evaluate the effect of Topping-off surgery on the adjacent segment of PLIF.
  65. doi LC-MS/MS Screening Strategy for Unknown Adducts to N-Terminal Valine in Hemoglobin Applied to Smokers and Nonsmokers
    Henrik Carlsson
    Department of Materials and Environmental Chemistry, Department of Analytical Chemistry, Stockholm University, SE 106 91 Stockholm, Sweden
    Chem Res Toxicol 27:2062-70. 2014
    ..developed for LC-MS/MS analysis of N-terminal valine adducts in Hb detached as fluorescein thiohydantoin (FTH) derivatives. The aim is to detect and identify a priori unknown Hb adducts in human blood samples...
  66. ncbi Indication of posterior lumbar interbody fusion for lumbar disc herniation
    Iwao Satoh
    Department of Orthopedic Surgery, Minoh City Hospital, Osaka, Japan
    J Spinal Disord Tech 19:104-8. 2006
    To examine whether lumbar disc herniation with massive extrusion and/or segmental instability can be an indicator for spinal fusion or not, by comparing the outcome of posterior lumbar interbody fusion (PLIF) and discectomy alone.
  67. doi Effects of respirator ambient air cooling on thermophysiological responses and comfort sensations
    David M Caretti
    a U S Army Edgewood Chemical Biological Center, Aberdeen Proving Ground, Maryland
    J Occup Environ Hyg 11:269-81. 2014
    ..Ambient air cooling was provided to respirators modified to blow air to the forehead (FHC) or to the forehead and the breathing zone (BZC) of a full-facepiece air-purifying respirator using a low-flow (45 ..
  68. doi Identification of H ferritin-dependent and independent genes in K562 differentiating cells by targeted gene silencing and expression profiling
    Roberta Misaggi
    Department of Experimental and Clinical Medicine, Magna Græcia University of Catanzaro, Salvatore Venuta Campus, Viale Europa, 88100 Catanzaro, Italy
    Gene 535:327-35. 2014
    ..We have recently demonstrated that the shRNA silencing of the ferritin heavy subunit (FHC) in a melanoma cell line is accompanied by a consistent modification of gene expression pattern leading to a ..
  69. pmc Prediction of volatile anesthetic binding sites in proteins
    John H Streiff
    Departments of Anesthesiology and Molecular Pharmacology and Experimental Therapeutics and Biochemistry and Molecular Biology, Mayo College of Medicine, Rochester, Minnesota, USA
    Biophys J 91:3405-14. 2006
    ..binding sites and unoccupied pockets within the known structures of VAs bound to serum albumin, luciferase, and apoferritin. We found that both the number of protein atoms and methyl hydrogen, which are within approximately 8 A of a ..
  70. ncbi Experimental study of the spill and vaporization of a volatile liquid
    Douglas Bohl
    Department of Mechanical and Aeronautical Engineering, Clarkson University, Potsdam, NY 13699, USA
    J Hazard Mater 140:117-28. 2007
    ..75 to 3.0m/s) also impacted the spreading of the spill. Planar laser-induced fluorescence (PLIF) was used to measure acetone vapor concentrations during the transient pool spreading and vaporization in a window ..
  71. pmc Plant ferritin--a source of iron to prevent its deficiency
    Magdalena Zielińska-Dawidziak
    Department of Food Biochemistry and Analysis, Faculty of Food Science and Nutrition, Poznan University of Life Sciences, 60 623 Poznań, Poland
    Nutrients 7:1184-201. 2015
    ..This protein captures huge amounts of iron ions inside the apoferritin shell and isolates them from the environment...
  72. ncbi Deep vein thrombosis due to migrated graft bone after posterior lumbosacral interbody fusion. Case report
    Hisashi Yoshimoto
    Department of Orthopaedic Surgery, Eniwa Hospital, Eniwa, Japan
    J Neurosurg Spine 6:47-51. 2007
    ..Her symptoms were successfully improved after posterior lumbar interbody fusion (PLIF) at L5-S1; however, notable swelling in her left leg suddenly developed 2 days postoperatively...
  73. doi Absolute rate coefficient of the gas-phase reaction between hydroxyl radical (OH) and hydroxyacetone: investigating the effects of temperature and pressure
    Ngoc Duy Vu
    The Department of Chemistry, University of Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium
    J Phys Chem A 117:12208-15. 2013
    ..the temperature range 290-500 K using pulsed-laser photolysis coupled to pulsed-laser induced fluorescence (PLP-PLIF). Hydroxyl radical was generated by pulsed photolysis of H2O2 at 248 nm...
  74. doi Investigation of optical fibers for high-repetition-rate, ultraviolet planar laser-induced fluorescence of OH
    Paul S Hsu
    Spectral Energies, LLC, 5100 Springfield Street, Suite 301, Dayton, Ohio 45431, USA
    Appl Opt 52:3108-15. 2013
    ..UV-grade fused-silica fibers being used for hydroxyl radical (OH) planar laser-induced fluorescence (PLIF) imaging...
  75. ncbi [Comparative study of dynamic neutralization system and posterior lumbar interbody fusion in treating lumbar degenerative disease]
    Bing Yang
    No 1 Department of Orthopedic Surgery, Hospital of Orthopedics of Yulin, Yulin Guangxi, 537000, P R China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 27:140-4. 2013
    To compare the short-term effectiveness between dynamic neutralization system (Dynesys) and posterior lumbar interbody fusion (PLIF) in the treatment of lumbar degenerative disease.
  76. doi FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis
    Fang Liu
    Department of Clinical Laboratory, the First People s Hospital in Jiangbei District, Chongqing 400020, China
    Mol Biol Rep 39:873-9. 2012
    ..One of the candidate proteins was identified as ferritin, heavy polypeptide 1(FTH1)...
  77. doi Nanoparticle-based immunosensor with apoferritin templated metallic phosphate label for quantification of phosphorylated acetylcholinesterase
    Dan Du
    Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, PR China
    Biosens Bioelectron 26:3857-63. 2011
    ..OP-AChE adducts by metal chelation with phospho-moieties, which was selectively recognized by lead phosphate-apoferritin labeled anti-AChE antibody (LPA-anti-AChE)...
  78. pmc Extension CT scan: its suitability for assessing fusion after posterior lumbar interbody fusion
    Hiroaki Nakashima
    Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya University Graduate School of Medicine, 65 Tsurumai, Shouwa ku, Nagoya, Aichi 466 8560, Japan
    Eur Spine J 20:1496-502. 2011
    Posterior lumbar interbody fusion (PLIF) is a popular procedure for treating lumbar canal stenosis with spinal instability, and several reports concerning fusion assessment methods exist...
  79. doi Differential epithelial and stromal protein profiles in keratoconus and normal human corneas
    R Joseph
    Department of Vision Sciences, University of Alabama at Birmingham, 924 18th Street South, Birmingham, AL 35294 4390, USA
    Exp Eye Res 92:282-98. 2011
    ..albumin, keratin 5, L-lactate dehydrogenase and annexin A8) and down-regulation of four proteins (FTH1 [Ferritin heavy chain protein 1], calpain small subunit 1, heat shock protein beta 1 and annexin A2)...
  80. doi Inhibition of constitutively activated nuclear factor-kappaB induces reactive oxygen species- and iron-dependent cell death in cutaneous T-cell lymphoma
    Michael K Kiessling
    Tumor Immunology Program, German Cancer Research Center DFKZ, Heidelberg, Germany
    Cancer Res 69:2365-74. 2009
    ..We show that inhibition of constitutively active NF-kappaB causes down-regulation of ferritin heavy chain (FHC) that leads to an increase of free intracellular iron, which, in turn, induces massive generation of ..
  81. doi Characterization of feline serum ferritin-binding proteins: the presence of a novel ferritin-binding protein as an inhibitory factor in feline ferritin immunoassay
    Hirofumi Sakamoto
    Laboratory of Veterinary Biochemistry, Kitasato University, Aomori, Japan
    Biometals 22:793-802. 2009
    ..found that feline serum more strongly inhibits the detection of canine liver ferritin by immunoassay than its apoferritin; putative FBPs probably conceal ferritin epitopes detected by anti-ferritin antibodies...
  82. ncbi [Surgical management of the failed back surgery syndrome (FBSS) using posterior lumbar interbody fusion (PLIF) with posterior transpedicular stabilization]
    V Kat'uch
    Neurochirurgická klinika LF UPJS a FNLP Kosice, Slovenska republika
    Rozhl Chir 89:450-8. 2010
    One of possibility of treatment FBSS is posterior lumbar interbody fusion, PLIF with posterior transpedicular stabilization.
  83. pmc Role of H-1 and H-2 subunits of soybean seed ferritin in oxidative deposition of iron in protein
    Jianjun Deng
    CAU and ACC Joint Laboratory of Space Food, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China
    J Biol Chem 285:32075-86. 2010
    ..The data show that, upon aerobic addition of 48-200 Fe(2+)/shell to apoferritin, iron oxidation occurs only at the diiron ferroxidase center of recombinant H1 (rH-1)...
  84. doi Clinical outcomes of posterior lumbar interbody fusion for lumbar foraminal stenosis: preoperative diagnosis and surgical strategy
    Kei Watanabe
    Niigata Central Hospital, 1 18Shinkocho, Chuoku, Niigata City, Niigata, Japan
    J Spinal Disord Tech 24:137-41. 2011
    A retrospective case study of the use of posterior lumbar interbody fusion (PLIF) to treat lumbar foraminal stenosis (LFS).
  85. doi Evaluation of keratic precipitates and corneal endothelium in Fuchs' heterochromic cyclitis by in vivo confocal microscopy
    A Labbe
    Department of Ophthalmology, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Br J Ophthalmol 93:673-7. 2009
    To analyse keratic precipitates in Fuchs' heterochromic cyclitis (FHC) by in-vivo confocal microscopy (IVCM).
  86. doi Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes
    Shigemiki Omiya
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Mol Cell Cardiol 46:59-66. 2009
    b>Ferritin heavy chain (FHC) protein was significantly reduced in murine failing hearts following left coronary ligation or thoracic transverse aortic constriction...
  87. pmc Transgenic mouse α- and β-cardiac myosins containing the R403Q mutation show isoform-dependent transient kinetic differences
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    J Biol Chem 288:14780-7. 2013
    Familial hypertrophic cardiomyopathy (FHC) is a major cause of sudden cardiac death in young athletes...
  88. doi Clinical outcomes and considerations of the lumbar interbody fusion technique for lumbar disk disease in adolescents
    Dae Woong Kwon
    Department of Spinal Neurosurgery, Spine and Spinal Cord Institute, Gangnam Severance Hospital, Yonsei University Collegeof Medicine, 712, Eonjuro, Gangnam Gu, Seoul, Republic of Korea
    Childs Nerv Syst 29:1339-44. 2013
    The posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) techniques are commonly used surgical methods for wide indications such as degeneration or trauma...
  89. doi Agglomeration of proteins in acoustically levitated droplets
    Friedmar Delissen
    BAM Federal Institute for Materials Research and Testing, Richard Willstaetter Str 11, 12489, Berlin, Germany
    Anal Bioanal Chem 392:161-5. 2008
    ..The microfocus beamline at BESSY was used as a source of intense X-ray radiation. Apoferritin (APO) was used as a model protein, and its aggregation behavior in a levitator was followed from a diluted ..
  90. doi De novo design of N-(pyridin-4-ylmethyl)aniline derivatives as KDR inhibitors: 3D-QSAR, molecular fragment replacement, protein-ligand interaction fingerprint, and ADMET prediction
    Yanmin Zhang
    Laboratory of molecular design and drug discovery, School of Science, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China
    Mol Divers 16:787-802. 2012
    ..screened using Glide (docking) and further evaluated with CoMFA prediction, protein-ligand interaction fingerprint (PLIF) and ADMET analysis...
  91. pmc HLA-B27 homodimers and free H chains are stronger ligands for leukocyte Ig-like receptor B2 than classical HLA class I
    Joanna Giles
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
    J Immunol 188:6184-93. 2012
    ..forms classical heterotrimeric complexes with β(2)-microglobulin (β2m) and peptide and (β2m free) free H chain (FHC) forms including B27 dimers (termed B27(2)) at the cell surface...
  92. ncbi Posterior lumbar interbody fusion for the management of spondylolisthesis
    P Devkota
    Department of Orthopaedics and Trauma Surgery, Gandaki Medical College Teaching Hospital Charak Hospital, Pokhara, Nepal
    Nepal Med Coll J 13:46-9. 2011
    ..There are several methods of treatment and posterior lumbar interbody fusion (PLIF) is one of them...
  93. pmc Cross-bridge kinetics in myofibrils containing familial hypertrophic cardiomyopathy R58Q mutation in the regulatory light chain of myosin
    P Mettikolla
    Department of Molecular Biology and Immunology and Center for Commercialization of Fluorescence Technologies, University of North Texas, Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Theor Biol 284:71-81. 2011
    Familial hypertrophic cardiomyopathy (FHC) is a heritable form of cardiac hypertrophy caused by single-point mutations in genes encoding sarcomeric proteins including ventricular myosin regulatory light chain (RLC)...
  94. doi Artificial luminescent protein as a bioprobe for time-gated luminescence bioimaging
    Xiangyou Liu
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China
    Chem Commun (Camb) 47:8139-41. 2011
    An artificial luminescent protein, apoferritin-encapsulated luminescent europium complex, has been designed/fabricated and displays good biocompatibility and long-lived luminescence, which means it can be used as a bioprobe to image ..
  95. pmc En bloc partial laminectomy and posterior lumbar interbody fusion in foraminal spinal stenosis
    Eung Ha Kim
    Department of Orthopedic Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea
    Asian Spine J 3:66-72. 2009
    ..A retrospective study...
  96. pmc Single molecule kinetics in the familial hypertrophic cardiomyopathy D166V mutant mouse heart
    Priya Muthu
    Department of Molecular Biology and Immunology and Center for Commercialization of Fluorescence Technologies, University of North Texas, Health Science Center, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA
    J Mol Cell Cardiol 48:989-98. 2010
    One of the sarcomeric mutations associated with a malignant phenotype of familial hypertrophic cardiomyopathy (FHC) is the D166V point mutation in the ventricular myosin regulatory light chain (RLC) encoded by the MYL2 gene...
  97. ncbi Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain
    N Zheng
    Molecular Biophysics Program, University of Texas Southwestern Medical Center at Dallas 75235, USA
    Mol Cell 1:79-87. 1997
    The E. coli protein, Fth, binds to 4.5S RNA through its M domain to form the signal recognition particle (SRP). The other domain of Fth (NG) is a GTPase, which binds and is coordinately regulated by its receptor, FtsY...
  98. ncbi Asymmetric septal hypertrophy in heterozygous cMyBP-C null mice
    Lucie Carrier
    INSERM U582, Institut de Myologie, Batiment Babinski, GH Pitié Salpétrière, Paris, France
    Cardiovasc Res 63:293-304. 2004
    Cardiac myosin-binding protein C (cMyBP-C) gene mutations are involved in familial hypertrophic cardiomyopathy (FHC)...
  99. ncbi Posterior lumbar interbody fusion for degenerative disc disease using a minimally invasive B-twin expandable spinal spacer: a multicenter study
    Yoram Folman
    Department of Orthopaedic Surgery, Hillel Yaffe Medical Center, Hadera, Israel
    J Spinal Disord Tech 16:455-60. 2003
    ..patients with chronic low back pain due to degenerative disc disease, treated by posterior lumbar interbody fusion (PLIF) using a newly designed ESS...
  100. ncbi A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity
    R Bottinelli
    Institute of Human Physiology, University of Pavia, Italy
    Circ Res 82:106-15. 1998
    Mutant contractile protein genes that cause familial hypertrophic cardiomyopathy (FHC) are presumed to encode mutant proteins that interfere with contractile function...
  101. doi The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a ferritin with low stability and no ferroxidase activity and with a partial nuclear localization
    Paola Ruzzenenti
    Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy
    Biochim Biophys Acta 1850:1267-73. 2015
    Three functional ferritin genes have been identified so far in mammals, and they encode the cytosolic Heavy (FTH) and Light chain (FTL) and the mitochondrial ferritin...

Research Grants58

  1. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    Bjorn C Knollmann; Fiscal Year: 2012
    Project Summary/Abstract Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal-dominant disease resulting from mutations in genes encoding sarcomeric proteins...
  2. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2013
    ..The cardiac hypertrophy, myofibrillar disarray and sudden death caused by familial hypertrophic cardiomyopathy (FHC) results from autosomal dominant mutations in sarcomeric proteins...
  3. Myosin ELC, a novel therapeutic target for FHC
    Danuta Szczesna-Cordary; Fiscal Year: 2013
    ..by the recent identification of several missense mutations shown to cause Familial Hypertrophic Cardiomyopathy (FHC), a genetic disorder manifested by ventricular enlargement, myofilament disarray and sudden cardiac death (SCD)...
  4. Functional Consequences of FHC-linked RLC Mutations.
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    Familial hypertrophic cardiomyopathy (FHC) is one of the pathological compensatory manifestations found in the heart resulting from its inability to adequately pump blood, thus leading to hypertrophy and often to premature cardiac death...
  5. The Role of the Proteasome in Troponin related Cardiomyopathies
    ALDRIN VERNO GOMES; Fiscal Year: 2013
    ..Mutations in cardiac troponin T (cTnT) are responsible for ~7% of all familial hypertrophic cardiomyopathy (FHC) cases...
  6. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna-Cordary; Fiscal Year: 2012
    Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease originating from mutations in genes that encode for the major contractile proteins of the heart, including the ventricular myosin regulatory (RLC) and essential ..
  7. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ..Coregulation of ferritin mRNAs, FTH and FTL, with iron trafficking proteins depends on a group of mRNA structures, the iron regulatory element (IRE) ..
  8. A TG model for functional effects of FHC mutations in b-cardiac myosin
    Susan Lowey; Fiscal Year: 2013
    ..Mutations in the ?-myosin heavy chain (MHC) are among the major causes of familial hypertrophic cardiomyopathy (FHC), a relatively widespread heart disease in humans...
  9. Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies
    Jil C Tardiff; Fiscal Year: 2013
    ..the known sarcomeric proteins have been implicated as causal for the disease and the familial form of the disorder (FHC) is thought to comprise over 50% of all cases...
  10. In Situ Sensing of Single Myosin Function in Hypertrophy Disease
    Thomas P Burghardt; Fiscal Year: 2013
    ..cardiac myosin heavy chain (MHC) and both of its light chains (MLCs) harbor familial hypertrophic cardiomyopathy (FHC)-linked mutations. MHC mutants are hypothesized to disrupt specific transduction pathways...
  11. Structural Comparison of Strongly-Bound Actomyosin States
    Dorit Hanein; Fiscal Year: 2009
    ..One prime cause of heart disease is familial hypertrophic cardiomyopathy (FHC), which is an inherited cardiac disease that frequently results in sudden death of young and otherwise healthy ..
  12. INTEGRATED MECHANISMS OF CARDIAC MALADAPTATION
    R John Solaro; Fiscal Year: 2013
    ..activation via AMPK/Paki (with emphasis on the evolution and rescue of familial hypertrophic cardiomyopathy (FHC);and via PKCe, and with emphasis on dilated cardiomyopathy, novel phosphorylation sites and on rescue...
  13. Troponin and myosin in regulation of muscle contraction and heart disease
    Zenon Grabarek; Fiscal Year: 2012
    A number of familial hypertrophic cardiomyopathy (FHC) causing mutations have been identified in the regulatory proteins, tropomyosin (Tm) and troponin (Tn)...
  14. Myosin structural and kinetic mechanisms that differentiate fast and slow muscle
    Douglas M Swank; Fiscal Year: 2012
    ..regarding how at least 8 different mutations in the converter cause either familial hypertrophic cardiomyopathy (FHC) or dilated cardiaomyopathy (DCM)...
  15. Spectroscopy of myosin light chain domain dynamics
    Osha Roopnarine; Fiscal Year: 2010
    ..how this is altered in muscle disease, focusing on LC mutations that cause familial hypertrophic cardiomyopathy (FHC)...
  16. Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System in
    Leighton T Izu; Fiscal Year: 2012
    ..Mice expressing genetically defined familiar hypertrophic cardiomyopathy (FHC) and spontaneous hypertensive rats will be examined...
  17. Molecular dynamics studies of muscle proteins
    EDWARD F PATE; Fiscal Year: 2010
    ..in the coiled-coil regulatory protein, tropomyosin, which are associated with familial hypertrophic cardiomyopathy (FHC)...
  18. A molecular study linking cTnT dynamics to genetic cardiomyopathy
    Jil C Tardiff; Fiscal Year: 2013
    ..this regulates the biophysics and physiology of the thin filament control of cardiac function in wildtype and known FHC-linked TNT1 mutations...
  19. TROPOMYOSIN AND THE REGULATION OF MUSCLE CONTRACTION
    SHERWIN LEHRER; Fiscal Year: 2009
    ..g., familial hypertrophic cardiomyopathy (FHC) resulting from mutations in Tm, TnT, Tnl and myosin...
  20. Ultrananocrystalline Diamond Microarray Biosensor for Neurochemical Detection
    Prabhu U Arumugam; Fiscal Year: 2012
    ..neurophysiological microelectrodes and instrumentation company, the expected annual sales for this product at FHC Inc...
  21. Animal models to study iron homeostasis
    Ruben Vidal; Fiscal Year: 2010
    ..promoters, these models will allow us to study the consequences of a loss of the ferroxidase activity of ferritin (Fth1 gene) and/or the loss of the iron storage function of ferritin (Ftl gene) in discrete cell populations in the CNS ..
  22. EFFECT OF CARDIOMYOPATHY MUTATIONS ON MYOSIN AND ACTIN
    KATHLEEN TRYBUS; Fiscal Year: 2004
    ..the beta-cardiac myosin heavy chain and in alpha-cardiac actin lead to either familial hypertrophic cardiomyopathy (FHC) or dilated cardiomyopathy (DCM)...
  23. FHC Tn Mutations: Functional Consequences & Mechanisms
    James Potter; Fiscal Year: 2005
    Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal dominant disease, which has been associated with mutations in almost every major cardiac sarcomeric protein...
  24. Conjugation of anticancer drugs
    Swati Nagar; Fiscal Year: 2010
    ..synthesize the major metabolites of RSV and test their role in cell proliferation with colon cancer cell lines (FHC controls, Caco-2, HT-29, and HCT-116) as our model...
  25. Functional consequences of FHC mutations in cardiac MyBPC
    JULIAN STELZER; Fiscal Year: 2013
    ....
  26. ALTERED CALCIUM REGULATION IN CARDIOMYOPATHIES
    P Chase; Fiscal Year: 2004
    ..protein troponin I (cTnI) have been identified as causal in some forms of familial hypertrophic cardiomyopathy (FHC)...
  27. LENGTH REGULATION OF CARDIAC CONTRACTION
    Donald Martyn; Fiscal Year: 2010
    ..We will also determine how phosphorylation effects are altered by FHC mutations of cTnI and how they influence stretch activation of cardiac muscle...
  28. Mechanisms of Tropomyosin Induced Hypertrophy
    David Wieczorek; Fiscal Year: 2006
    ..thin filament protein, cause both skeletal and cardiac myopathies, including familial hypertrophic cardiomyopathy (FHC). We have deve oped novel mouse mode s whereby these mutations induce concentric or dilated cardiomyopathy...
  29. Effects of opiates on neurons and their impact on HIV neuropathology
    Olimpia Meucci; Fiscal Year: 2013
    ..e. their ability to regulate the protein ferritin heavy chain (FHC) in neurons - andits contribution to HIV neuropathology...
  30. Structure Comparison Of Strongly bound Actomyosin States
    Dorit Hanein; Fiscal Year: 2005
    ..by the fact that myosin mutations have been implicated for example in familial hypertrophic cardiomyopathy (FHC), the most common cause of sudden death in otherwise healthy young individuals...
  31. IL-21 dependent immunity to microsporidia
    IMTIAZ AHMED KHAN; Fiscal Year: 2013
    ..Preliminary studies from our laboratory suggest that FTH (Follicular T helper cells) subset of CD4+ T cells, main producers of IL- 21 play a pivotal role in the induction ..
  32. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    ..NeuroNexus is leading this project in collaboration with FHC, the University of Michigan and consultants from the Cleveland Clinic...
  33. Iron Trafficking to Ribonucleotide Reductases
    DANIEL KOSMAN; Fiscal Year: 2006
    ..This pool is sampled by membrane permeant chelators, the iron response element binding protein (IRP1), and apoferritin. We have shown that removing iron from this pool by either chelation or over-production of ferritin inhibits ..
  34. CLUSTERIN AND RENAL INJURY
    Mark Rosenberg; Fiscal Year: 2004
    ..to in situ formed immune complexes (nephrotoxic serum nephritis) and the other to circulating immune complexes (apoferritin GN)...
  35. The Role of Sphingolipids in Inflammatory Bowel Disease
    ASHLEY SNIDER; Fiscal Year: 2009
    ..newly developed SK1 inhibitors as to their ability to inhibit TNFa activation of SK1 and downstream signaling in FHC human colon epithelial cells. We will examine these downstream effects by Real Time-RTPCR and western blotting...
  36. Software Guided Localization of the Subthalamic Nucleus During DBS Surgeries
    Peter Novak; Fiscal Year: 2010
    ..real time analytical tool that is integrated into a currently available clinical electrophysiological workstation (FHC's Guideline 4000) for use in current functional neurosurgical procedures...
  37. High throughput screening of a general anesthetic binding site
    Roderic Eckenhoff; Fiscal Year: 2009
    ..screen at NCGC for general anesthetics based on binding to a well characterized site in a GABAA mimic, apoferritin. The assay is based on competition of compounds with enhanced 1-aminoanthracene fluorescence...
  38. PROPHYLAXIS OF FETAL HEMATOPOIETIC CELLS FOR FIV
    Ayalew Mergia; Fiscal Year: 2002
    ..We are poised to overcome these impediments by using a virtually limitless source of fetal hematopoietic cells (FHC) which are rich in immunologically-naive stem cells...
  39. CAGED METAL CLUSTER AND COLLOID IMMUNOPROBES
    Richard Powell; Fiscal Year: 1993
    ..encapsulated within coordination shells of stabilizing ligands, the naturally occurring hollow protein apoferritin, or new synthetic inclusion molecules...
  40. MOLECULAR MECHANICS OF FHC & DCM MUTANT ACTOMYOSIN
    David Warshaw; Fiscal Year: 2004
    ..mutations to cardiac actin and myosin's molecular structure have on patients afflicted with familial hypertrophic (FHC) and dilated cardiomyopathy (DCM)...
  41. Myosin structural regions that determine muscle shorten*
    DOUGLAS SWANK; Fiscal Year: 2006
    ..highly informative as the converter is a hotspot for mutations that lead to familial hypertrophic cardiomyopathy (FHC). FHC is an inherited genetic disease that is a major cause of sudden death among young adults...
  42. CARDIAC TROPONIN T MUTATIONS AND HEART FUNCTION
    Amy Sehnert; Fiscal Year: 2003
    ..It is clinically relevant to the human genetic disorder, familial hypertrophic cardiomyopathy (FHC)...
  43. High Resolution Structural Biology of the SRP GTPase
    DOUGLAS FREYMANN; Fiscal Year: 2005
    ..investigation to address its structural basis are proposed: First, the structures of the apo- and nucleotide-bound Fth GTPase 'NG' domain are being determined at -~ 1.0 A resolution...
  44. INTERDOMAIN COMMUNICATION IN E. COLI SRP
    Elena Falkovskaia; Fiscal Year: 2003
    ..This aim will be accomplished using a combination of mutagenesis of Fth for labeling purposes, steady-state and time-resolved fluorescence spectroscopy to assess the change in the ..
  45. MLC2V AND 2A IN CARDIAC DEVELOPMENT AND DISEASE
    Ju Chen; Fiscal Year: 2003
    ..role in ventricular papillary muscle and cardiac function, and impairment of MLC2v phosphorylation will result in FHC. The overall goals of the proposal are to understand the functional differences between two cardiac MLC2 isoforms, ..
  46. INTRINSIC PROBES OF SMOOTH MUSCLE MYOSIN DYNAMICS
    Christopher Berger; Fiscal Year: 2009
    ..For example, FHC (familial hypertrophic cardiomyopathy) is an inherited, often lethal disease caused by point mutations at key ..
  47. Deep Brain Microelectrode Array For Functional Neurosurgery
    JAMILLE HETKE; Fiscal Year: 2006
    ..project, NeuroNexus Technologies, a leading supplier of microfabricated, microscale neural probes, will team with FHC, Inc...
  48. Views and Approaches Toward Research Integrity Among IRBs
    Robert Klitzman; Fiscal Year: 2007
    ..We anticipate that the data from this study will serve as a significant foundation in assisting future research and the improvement of Rl through guidelines, education and other capacity building. [unreadable] [unreadable] [unreadable]..
  49. Rotation of Single Cross-Bridge in Skeletal Muscle Fiber
    Julian Borejdo; Fiscal Year: 2007
    ..This is expected to provide definitive answers about the mechanism of contraction of skeletal muscle. ..
  50. Anesthetic Bound Calmodulin:Structure Dynamics Function
    John Streiff; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  51. Gordon Research Conference:Cardiac Regulatory Mechanisms
    R Solaro; Fiscal Year: 2002
    ..Much of the time of the meeting is devoted to debates and discussion. Presentations of late breaking science from young investigator will be added from the posters submitted to the meeting. ..
  52. Cellular Mechanisms in the Pathogenesis of FHC
    JIL TARDIFF; Fiscal Year: 2006
    ..Familial Hypertrophic Cardiomyopathy (FHC) is a primary myocardial disorder characterized by a striking degree of both genetic and clinical heterogeneity...
  53. Improved Confocal Microscope: Detection & Functionality
    Julian Borejdo; Fiscal Year: 2005
    ..To facilitate a future commercialization, a microscope maintenance/modification company that is interested in distribution of the product version of the modification package has been identified. ..
  54. Pak1 Regulation of Cardiac Protein Phosphorylation
    Katherine Sheehan; Fiscal Year: 2005
    ..Together these data will provide evidence for a novel pathway of activation of PP2A and a role for concomitant regulation of contractile and intracellular Ca2+ handling. ..
  55. IMAGING MELANIN IN MELANOCYTES
    Julian Borejdo; Fiscal Year: 2003
    ..The modifications are relatively simple, inexpensive and not tied to a specific brand of instrument. It is expected that the method will find application in a small diagnostic laboratory. ..
  56. Views of Privacy of Genetic Information
    Robert Klitzman; Fiscal Year: 2005
    ..The findings of this study can enhance further policy, professional and public education, and future research in this area. ..