FTH1

Summary

Gene Symbol: FTH1
Description: ferritin, heavy polypeptide 1
Alias: FHC, FTH, FTHL6, PIG15, PLIF, apoferritin, cell proliferation-inducing gene 15 protein, ferritin H subunit, ferritin heavy chain, placenta immunoregulatory factor, proliferation-inducing protein 15
Species: human

Top Publications

  1. ncbi A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Blood Cells Mol Dis 27:783-802. 2001
  2. ncbi Epidural abscess and discitis complicating instrumented posterior lumbar interbody fusion: a case report
    Jonathan J Carmouche
    University of Rochester School of Medicine and Dentistry, Department of Orthopaedic Surgery, Spine Division, Rochester, New York, USA
    Spine (Phila Pa 1976) 29:E542-6. 2004
  3. doi Dose-dependent inhibition of diclofenac sodium on posterior lumbar interbody fusion rates
    Jose Miguel T Lumawig
    Department of Orthopedics, Philippine General Hospital, Taft Avenue, Manila, Philippines
    Spine J 9:343-9. 2009
  4. ncbi Segmental stability and compressive strength of posterior lumbar interbody fusion implants
    A Tsantrizos
    Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 25:1899-907. 2000
  5. ncbi Induction of ferritin synthesis in cells infected with Mengo virus
    M R Mulvey
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 271:9851-7. 1996
  6. pmc Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease
    Neil V Morgan
    Wellchild Paediatric Research Centre and Department of Medical and Molecular Genetics, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom
    PLoS Genet 6:e1000833. 2010
  7. doi Effects of ascorbic acid, phytic acid and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model
    Fuxia Jin
    USDA ARS, The Robert W Holley Center for Health and Agriculture, Tower Road, Ithaca, New York 14853, USA
    Br J Nutr 101:972-81. 2009
  8. ncbi Outcome of clinical versus genetic family screening in hypertrophic cardiomyopathy with focus on cardiac beta-myosin gene mutations
    Ole Havndrup
    Department of Medicine B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cardiovasc Res 57:347-57. 2003
  9. pmc Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice
    Theodore P Abraham
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Cardiovasc Res 82:84-92. 2009
  10. ncbi [Adjacent segment degeneration after lumbosacral fusion in spondylolisthesis: a retrospective radiological and clinical analysis]
    P Zencica
    Ortopedická klinika FN Brno Bohunice
    Acta Chir Orthop Traumatol Cech 77:124-30. 2010

Detail Information

Publications174 found, 100 shown here

  1. ncbi A study of genes that may modulate the expression of hereditary hemochromatosis: transferrin receptor-1, ferroportin, ceruloplasmin, ferritin light and heavy chains, iron regulatory proteins (IRP)-1 and -2, and hepcidin
    P L Lee
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Blood Cells Mol Dis 27:783-802. 2001
    ..These were further examined for association with differences in iron accumulation as measured by plasma transferrin saturation and ferritin levels, but no such association could be documented...
  2. ncbi Epidural abscess and discitis complicating instrumented posterior lumbar interbody fusion: a case report
    Jonathan J Carmouche
    University of Rochester School of Medicine and Dentistry, Department of Orthopaedic Surgery, Spine Division, Rochester, New York, USA
    Spine (Phila Pa 1976) 29:E542-6. 2004
    A case of epidural abscess and discitis following instrumented PLIF using a single carbon fiber interbody cage is presented.
  3. doi Dose-dependent inhibition of diclofenac sodium on posterior lumbar interbody fusion rates
    Jose Miguel T Lumawig
    Department of Orthopedics, Philippine General Hospital, Taft Avenue, Manila, Philippines
    Spine J 9:343-9. 2009
    ..It is very popular as a first-line treatment for acute pain, even perioperatively for spine fusion patients. Review of published literature reveals no studies done on the effect of diclofenac sodium on spine fusion rates...
  4. ncbi Segmental stability and compressive strength of posterior lumbar interbody fusion implants
    A Tsantrizos
    Orthopaedic Research Laboratory, Division of Orthopaedic Surgery, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 25:1899-907. 2000
    ..Three posterior lumbar interbody fusion implant constructs (Ray Threaded Fusion Cage, Contact Fusion Cage, and PLIF Allograft Spacer) were tested nondestructively in axial rotation, flexion-extension, and lateral bending...
  5. ncbi Induction of ferritin synthesis in cells infected with Mengo virus
    M R Mulvey
    Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 271:9851-7. 1996
    ..from infected murine L929 cells showed a 4- and 6-fold increase in the intracellular concentrations of H and L apoferritin subunits, respectively. This differential expression altered the H/L subunit ratio from 3...
  6. pmc Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease
    Neil V Morgan
    Wellchild Paediatric Research Centre and Department of Medical and Molecular Genetics, University of Birmingham College of Medical and Dental Sciences, Edgbaston, Birmingham, United Kingdom
    PLoS Genet 6:e1000833. 2010
    ..In most cases the pathophysiology is unclear and treatment is nonspecific. Faisalabad histiocytosis (FHC) (MIM 602782) has been classed as an autosomal recessively inherited form of histiocytosis with similarities to ..
  7. doi Effects of ascorbic acid, phytic acid and tannic acid on iron bioavailability from reconstituted ferritin measured by an in vitro digestion-Caco-2 cell model
    Fuxia Jin
    USDA ARS, The Robert W Holley Center for Health and Agriculture, Tower Road, Ithaca, New York 14853, USA
    Br J Nutr 101:972-81. 2009
    ..Horse spleen apoferritin was chemically reconstituted into an animal-type ferritin (HSF) and a plant-type ferritin (P-HSF) according to ..
  8. ncbi Outcome of clinical versus genetic family screening in hypertrophic cardiomyopathy with focus on cardiac beta-myosin gene mutations
    Ole Havndrup
    Department of Medicine B, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Cardiovasc Res 57:347-57. 2003
    Familial hypertrophic cardiomyopathy (FHC) is caused by mutations in genes encoding cardiac sarcomere proteins. Although available, genetic analyses are generally not used clinically...
  9. pmc Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice
    Theodore P Abraham
    Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA
    Cardiovasc Res 82:84-92. 2009
    ..the ventricular myosin regulatory light chain (RLC) were identified to cause familial hypertrophic cardiomyopathy (FHC)...
  10. ncbi [Adjacent segment degeneration after lumbosacral fusion in spondylolisthesis: a retrospective radiological and clinical analysis]
    P Zencica
    Ortopedická klinika FN Brno Bohunice
    Acta Chir Orthop Traumatol Cech 77:124-30. 2010
    Whereas the posterior lumbar interbody fusion (PLIF) technique with pedicle screw fixation has shown satisfactory clinical results, solid fusion has been reported to accelerate degenerative changes at adjacent unfused levels, especially ..
  11. ncbi Risk factors for adjacent segment degeneration after PLIF
    Shin ya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    Spine (Phila Pa 1976) 29:1535-40. 2004
    A retrospective study of 87 patients who underwent posterior lumbar interbody fusion (PLIF) at L4-L5 for L4 degenerative spondylolisthesis.
  12. ncbi QT dispersion in alpha-myosin heavy-chain familial hypertrophic cardiomyopathy mice
    L M Bevilacqua
    Department of Cardiology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatr Res 45:643-7. 1999
    Patients with familial hypertrophic cardiomyopathy (FHC) are at risk for ventricular arrhythmias and sudden death...
  13. ncbi A novel missense mutation, Leu390Val, in the cardiac beta-myosin heavy chain associated with pronounced septal hypertrophy in two families with hypertrophic cardiomyopathy
    O Havndrup
    Department of Medicine B, The Heart Center, Rigshospitalet, University of Copenhagen, Denmark
    Scand Cardiovasc J 34:558-63. 2000
    An examination of the genetic background and phenotypic presentation of familial hypertrophic cardiomyopathy (FHC) with respect to specific mutations in the MYH7-gene encoding the cardiac beta-myosin heavy chain.
  14. ncbi Posterior lumbar interbody fusion with facet-screw fixation
    T Stonecipher
    Everett Clinic, Everett, WA 98201
    Spine (Phila Pa 1976) 14:468-71. 1989
    The optimal surgical construct for lumbar fusion remains controversial. The posterior lumbar interbody fusion (PLIF) operation offers advantages including total nuclear disc excision, restoration of disc-space height, root decompression, ..
  15. doi Sex life and sexual function in men and women before and after total disc replacement compared with posterior lumbar fusion
    Svante Berg
    Stockholm Spine Center, Löwenströmska Hospital, SE 19489, Upplands Vasby, Stockholm, Sweden
    Spine J 9:987-94. 2009
    ..This has led to concern as to whether anterior surgery should be employed in men, at least in younger age groups...
  16. doi Characterization of feline serum ferritin-binding proteins: the presence of a novel ferritin-binding protein as an inhibitory factor in feline ferritin immunoassay
    Hirofumi Sakamoto
    Laboratory of Veterinary Biochemistry, Kitasato University, Aomori, Japan
    Biometals 22:793-802. 2009
    ..found that feline serum more strongly inhibits the detection of canine liver ferritin by immunoassay than its apoferritin; putative FBPs probably conceal ferritin epitopes detected by anti-ferritin antibodies...
  17. doi Volatile anesthetic binding to proteins is influenced by solvent and aliphatic residues
    John H Streiff
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294 1150, USA
    J Chem Inf Model 48:2066-73. 2008
    ..that exceeded minimum values observed in the VA binding sites of serum albumin, firefly luciferase, and apoferritin. We found that the structures of VA binding proteins are enriched in these pockets and that the predicted ..
  18. ncbi Ferritin induction protects cortical astrocytes from heme-mediated oxidative injury
    R F Regan
    Department of Surgery, Thomas Jefferson University, 1020 Sansom Street, 239 Thompson Building, Philadelphia, PA 19107, USA
    Neuroscience 113:985-94. 2002
    ..An enhanced ferritin band was detected on immunoblots from cultures that were treated with purified apoferritin, consistent with astrocytic ferritin uptake...
  19. ncbi Human homozygous R403W mutant cardiac myosin presents disproportionate enhancement of mechanical and enzymatic properties
    Dagmar I Keller
    INSERM U582, Institut de Myologie, , , 47, , 75651 Paris Cedex 13, France
    J Mol Cell Cardiol 36:355-62. 2004
    Familial hypertrophic cardiomyopathy (FHC) is associated with mutations in 11 genes encoding sarcomeric proteins. Most families present mutations in MYBPC3 and MYH7 encoding cardiac myosin-binding protein C and beta-myosin heavy chain...
  20. ncbi Two pathways of iron uptake in bovine spleen apoferritin dependent on iron concentration
    Koichi Orino
    Laboratory of Biochemistry, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, Japan
    Biometals 15:59-63. 2002
    Iron incorporation by bovine spleen apoferritin either with ferrous ammonium sulfate in different buffers or with ferrous ammonium sulfate and phosphate was studied. Iron uptake and iron autoxidation were recorded spectrophotomerically...
  21. ncbi Posterior lumbar interbody fusion using posterolateral placement of a single cylindrical threaded cage
    J Zhao
    Department of Orthopedic Surgery, Changhai Hospital, Shanghai, People s Republic of China
    Spine (Phila Pa 1976) 25:425-30. 2000
    STUDY DESIGN: An in vitro biomechanical study of posterior lumbar interbody fusion (PLIF) with threaded cages was performed on 18 bovine lumbar functional spinal units...
  22. pmc Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone
    Susan Lowey
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, VT 05405, USA
    J Biol Chem 283:20579-89. 2008
    ..in the beta-myosin heavy chain (MHC) was the first mutation to be linked to familial hypertrophic cardiomyopathy (FHC), a primary disease of heart muscle...
  23. ncbi Social protection in Brazil: universalism and targeting in the FHC and Lula administrations
    Nilson do Rosário Costa
    Departamento de Ciências Sociais, Escola Nacional de Saude Publica, FIOCRUZ, Rio de Janeiro, RJ, 21045 210, Brazil
    Cien Saude Colet 14:693-706. 2009
    ..Targeting is an innovation directly associated with the adjustment agenda. It reveals that under the FHC and Lula administrations there was an identical adoption of targeted social programs...
  24. pmc Fluorescence lifetime of actin in the familial hypertrophic cardiomyopathy transgenic heart
    P Mettikolla
    Department of Molecular Biology and Immunology and Center for Commercialization of Fluorescence Technologies, University of North Texas, 3500 Camp Bowie Blvd, Fort Worth, Texas 76107, USA
    Biochemistry 48:1264-71. 2009
    ..myosin regulatory light chain (RLC) can cause a malignant phenotype of familial hypertrophic cardiomyopathy (FHC)...
  25. ncbi Scavenger receptors facilitate protein transport in the trophotaenial placenta of the goodeid fish, Ameca splendens (Teleostei: Atheriniformes)
    Joachim F Schindler
    Institut fur Anatomie, Universitat Regensburg, Regensburg, Germany
    J Exp Zool A Comp Exp Biol 299:197-212. 2003
    ..Binding to TACs of NF was completely inhibitable by proteins containing multiple lysine residues such as apoferritin, bovine serum albumin (BSA), human transferrin (HTf), fetuin, hemoglobin, myoglobin, cytochrome c, ubiquitin, ..
  26. ncbi Comparative architecture of silks, fibrous proteins and their encoding genes in insects and spiders
    Catherine L Craig
    Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    Comp Biochem Physiol B Biochem Mol Biol 133:493-507. 2002
    ..All of the sequenced fibroin silks (Flag or silk from flagelliform gland in spiders; Fhc or heavy chain fibroin silks produced by Lepidoptera larvae) are made up of hierarchically organized, repetitive ..
  27. pmc Comparative study of PILF and TLIF treatment in adult degenerative spondylolisthesis
    Deng Lu Yan
    Orthopedic Department, West China Hospital, Sichuan University, 610041, Chengdu, Sichuan, Peoples Republic of China
    Eur Spine J 17:1311-6. 2008
    This study is to compare the therapeutic effect of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) with pedicle screw fixation on treatment in adult degenerative spondylolisthesis...
  28. ncbi Cage migration in spondylolisthesis treated with posterior lumbar interbody fusion using BAK cages
    Liang Chen
    Department of Orthopaedic Surgery, First Affiliated Hospital of Suzhou University, Suzhou, PRC
    Spine (Phila Pa 1976) 30:2171-5. 2005
    A retrospective study was conducted to review the complication of cage migration in posterior lumbar interbody fusion (PLIF) with the Bagby and Kuslich method.
  29. ncbi Residual sagittal motion after lumbar fusion: a finite element analysis with implications on radiographic flexion-extension criteria
    Christopher M Bono
    Boston University School of Medicine, Department of Orthopaedic Surgery, Boston, MA, USA
    Spine (Phila Pa 1976) 32:417-22. 2007
    ..Finite element analysis of a lumbar fusion model...
  30. ncbi Low-grade isthmic spondylolisthesis treated with instrumented posterior lumbar interbody fusion in U.S. servicemen
    Robert W Molinari
    Department of Orthopaedic Surgery, University of Rochester Spine Center, Rochester, New York, USA
    J Spinal Disord Tech 18:S24-9. 2005
    ..The purpose was to evaluate patient-assessed function/pain/satisfaction and military job performance in U.S. servicemen treated with posterior lumbar interbody fusion (PLIF).
  31. doi Downregulation of ferritin heavy chain increases labile iron pool, oxidative stress and cell death in cardiomyocytes
    Shigemiki Omiya
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Mol Cell Cardiol 46:59-66. 2009
    b>Ferritin heavy chain (FHC) protein was significantly reduced in murine failing hearts following left coronary ligation or thoracic transverse aortic constriction...
  32. ncbi PLIF with a titanium cage and excised facet joint bone for degenerative spondylolisthesis--in augmentation with a pedicle screw
    Koichiro Okuyama
    Department of Orthopedic Surgery, Akita Rosai Hospital, Akita 018 5604, Japan
    J Spinal Disord Tech 20:53-9. 2007
    To determine the validity of posterior lumbar interbody fusion (PLIF) using a titanium cage filled with excised facet joint bone and a pedicle screw for degenerative spondylolisthesis.
  33. ncbi [Clinical classification and surgical options of the far-lateral lumbar disc herniation]
    Fang Li
    Institute of Traumatology and Orthopedics, General Hospital of Beijing Military Command, Beijing 100700, China
    Zhonghua Wai Ke Za Zhi 47:1553-6. 2009
    ..To suggest the clinical classification of the far-lateral lumbar disc herniation and offer the considerations for clinical choice of different surgical procedures...
  34. pmc Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase
    Syevda G Sirenko
    Department of Pharmacology, Georgetown University Medical Center, Washington, DC, USA
    J Physiol 575:201-13. 2006
    Troponin T (TnT) mutations that cause familial hypertrophic cardiomyopathy (FHC) and sudden cardiac death frequently increase myofilament Ca2+ sensitivity, suggesting that their Ca2+-sensitizing effect contributes importantly to the FHC ..
  35. ncbi Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networks
    Chaya Moroz
    Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel
    Exp Hematol 34:159-66. 2006
    Placenta immunomodulator ferritin (PLIF) is a cloned human chimeric ferritin H chain with a novel non-ferritin C-terminal 48 amino acid sequence (C48). Recombinant PLIF-C48 exhibited cell-mediated immunosuppression...
  36. ncbi Posterior lumbar interbody fusion for degenerative spondylolisthesis: restoration of sagittal balance using insert-and-rotate interbody spacers
    William Sears
    Department of Neurosurgery, Royal North Shore Hospital, Pacific Highway, St Leonards, NSW 2065, Australia
    Spine J 5:170-9. 2005
    ..The insert-and-rotate posterior lumbar interbody fusion (PLIF) technique, first described by Jaslow in 1946, may enable surgeons to safely and effectively correct sagittal ..
  37. ncbi A mutant tropomyosin that causes hypertrophic cardiomyopathy is expressed in vivo and associated with an increased calcium sensitivity
    R Bottinelli
    Institute of Human Physiology, University of Pavia, Italy
    Circ Res 82:106-15. 1998
    Mutant contractile protein genes that cause familial hypertrophic cardiomyopathy (FHC) are presumed to encode mutant proteins that interfere with contractile function...
  38. pmc En bloc partial laminectomy and posterior lumbar interbody fusion in foraminal spinal stenosis
    Eung Ha Kim
    Department of Orthopedic Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea
    Asian Spine J 3:66-72. 2009
    ..A retrospective study...
  39. ncbi Lumbar trapezoid plate for lumbar spondylolisthesis. A clinical study on preoperative and postoperative instability
    Y Kamioka
    Orthopedic Department, Sanraku Hospital, Japan
    Spine (Phila Pa 1976) 15:1198-203. 1990
    ..For this purpose, it is considered important to prevent grafted bones of the posterior lumbar interbody fusion (PLIF) from collapse and to maintain the achieved alignment of the lumbar spine.
  40. ncbi Posterior lumbar interbody fusion versus posterolateral fusion in adult isthmic spondylolisthesis
    Per Ekman
    Karolinska Institutet, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden
    Spine (Phila Pa 1976) 32:2178-83. 2007
    ..A prospective study with historical controls...
  41. doi Radiological comparison of instrumented posterior lumbar interbody fusion with one or two closed-box plasmapore coated titanium cages: follow-up study over more than seven years
    Stefan Kroppenstedt
    Universitätsklinikum Charité Campus Virchow Klinikum, Augustenburger Platz, Berlin, Germany
    Spine (Phila Pa 1976) 33:2083-8. 2008
    ..A retrospective clinical study with a follow-up of more than 7 years was conducted...
  42. doi [Corticosteroid therapy and secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis and idiopathic chronic anterior uveitis]
    C Heinz
    Augenabteilung, St Franziskus Hospital, Munster, Germany
    Klin Monbl Augenheilkd 227:413-7. 2010
    ..This study examines the influence of corticosteroid therapy on the incidence of secondary elevated intraocular pressure in patients with Fuchs heterochromic cyclitis (FHC) and chronic anterior uveitis.
  43. ncbi Apoferritin-templated yttrium phosphate nanoparticle conjugates for radioimmunotherapy of cancers
    Hong Wu
    Pacific Northwest National Laboratory, Richland, WA 99352, USA
    J Nanosci Nanotechnol 8:2316-22. 2008
    We report a templated-synthetic approach based on protein-cage of apoferritin to prepare radionuclide nanoparticle (NP) conjugates...
  44. pmc Evaluation of a recombinant Hc of Clostridium botulinum neurotoxin serotype F as an effective subunit vaccine
    Yun Zhou Yu
    Beijing Institute of Biotechnology, 20 Dongdajie St, Fengtai District, Beijing 100071, China
    Clin Vaccine Immunol 15:1819-23. 2008
    A new gene encoding the Hc domain of Clostridium botulinum neurotoxin serotype F (FHc) was designed and completely synthesized with oligonucleotides. A soluble recombinant Hc of C...
  45. ncbi Immune complex glomerulonephritis in C4- and C3-deficient mice
    R J Quigg
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Kidney Int 53:320-30. 1998
    ..glomerulonephritis by actively immunizing C4-deficient (C4 -/-), C3 deficient (C3 -/-) and wild-type mice with apoferritin. Wild-type animals with an intact complement system produced anti-apoferritin IgG and IgM antibodies, and ..
  46. ncbi Achievement of normal sagittal plane alignment using a wedged carbon fiber reinforced polymer fusion cage in treatment of spondylolisthesis
    John W Brantigan
    South Texas Orthopaedic and Spinal Surgery Associates, 9150 Huebner Road, San Antonio, TX 78240, USA
    Spine J 3:186-96. 2003
    ..A wedged-shaped carbon-fiber-reinforced polymer (CFRP) cage implant filled with autologous bone was designed to allow surgeons to more easily achieve normal sagittal plane alignment in posterior lumbar interbody fusion (PLIF).
  47. ncbi Surgical complications of posterior lumbar interbody fusion with total facetectomy in 251 patients
    Shinya Okuda
    Department of Orthopaedic Surgery, Osaka Rosai Hospital, Osaka, Japan
    J Neurosurg Spine 4:304-9. 2006
    Previous studies of surgical complications associated with posterior lumbar interbody fusion (PLIF) are of limited value due to intrastudy variation in instrumentation and fusion techniques...
  48. ncbi Variable clinical manifestation of a novel missense mutation in the alpha-tropomyosin (TPM1) gene in familial hypertrophic cardiomyopathy
    Roselie J Jongbloed
    Department of Genetics and Cell Biology, University of Maastricht, Joseph Bechlaan 113, 6229 GR Maastricht, The Netherlands
    J Am Coll Cardiol 41:981-6. 2003
    ..This study was initiated to identify the disease-causing genetic defect in a family with hypertrophic cardiomyopathy (HCM) and high incidence of sudden death...
  49. ncbi Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils
    Bogdan Iorga
    Institute of Vegetative Physiology, University of Cologne, Robert Koch Strasse 39, Cologne, Germany
    Cardiovasc Res 77:676-86. 2008
    ..the functional consequences of the Lys184 deletion in murine cardiac troponin I (mcTnI(DeltaK184)), we have studied the primary effects of this mutation linked to familial hypertrophic cardiomyopathy (FHC) at the sarcomeric level.
  50. ncbi Iron(III) complexation of Desferrioxamine B encapsulated in apoferritin
    José M Domínguez-Vera
    Departamento de Quimica Inorganica, Facultad de Ciencias, Universidad de Granada, 18071 Granada, Spain
    J Inorg Biochem 98:469-72. 2004
    The dissociation of apoferritin into subunits at pH 2 followed by its reformation at pH 7...
  51. pmc Familial hypertrophic cardiomyopathy. Microsatellite haplotyping and identification of a hot spot for mutations in the beta-myosin heavy chain gene
    E Dausse
    Institut National de la Sante et de la Recherche Medicale, U127, Hopital Lariboisiere, Paris, France
    J Clin Invest 92:2807-13. 1993
    Familial hypertrophic cardiomyopathy (FHC) is a clinically and genetically heterogeneous disease. The first identified disease gene, located on chromosome 14q11-q12, encodes the beta-myosin heavy chain...
  52. doi Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms
    Giulia Mearini
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Cardiovasc Res 85:357-66. 2010
    Familial hypertrophic cardiomyopathy (FHC) is frequently caused by cardiac myosin-binding protein C (cMyBP-C) gene mutations, which should result in C-terminal truncated mutants...
  53. ncbi Mutations in beta-myosin S2 that cause familial hypertrophic cardiomyopathy (FHC) abolish the interaction with the regulatory domain of myosin-binding protein-C
    M Gruen
    Max Planck Institut fur molekulare Physiologie, Rheinlanddamm 201, Dortmund, 44139, Germany
    J Mol Biol 286:933-49. 1999
    ..In this region, several mutations in beta-myosin are associated with FHC; however, their molecular implications remained unclear...
  54. ncbi Outcome of one-level posterior lumbar interbody fusion for spondylolisthesis and postoperative intervertebral disc degeneration adjacent to the fusion
    N Miyakoshi
    Department of Orthopedic Surgery, Akita University School of Medicine, Akita Japan miyakoshodoc med akita u ac jp
    Spine (Phila Pa 1976) 25:1837-42. 2000
    ..of the clinical and radiologic records of patients who underwent one-level posterior lumbar interbody fusion (PLIF) at L4-L5...
  55. ncbi Problems of posterior lumbar interbody fusion (PLIF) for the rheumatoid spondylitis of the lumbar spine
    Masahiro Inaoka
    Department of Orthopaedic Surgery, Nissay Hospital, 3 8, Itachibori 6 chome, Nishi ku, Osaka 550 0012, Japan
    Arch Orthop Trauma Surg 122:73-9. 2002
    We performed posterior lumbar interbody fusion (PLIF) on 7 patients with rheumatoid spondylitis (RA) of the lumbar spine with severe low-back pain and/or cauda equina symptoms, and evaluated the effectiveness of PLIF for the lumbar spinal ..
  56. ncbi A carbon fiber implant to aid interbody lumbar fusion. Two-year clinical results in the first 26 patients
    J W Brantigan
    Department of Surgery, Division of Orthopaedics, Creighton University, Omaha, Nebraska
    Spine (Phila Pa 1976) 18:2106-7. 1993
    The success of posterior lumbar interbody fusion (PLIF) has been limited by mechanical and biologic deficiencies of the donor bone...
  57. ncbi Chemokine CXCL12 induces binding of ferritin heavy chain to the chemokine receptor CXCR4, alters CXCR4 signaling, and induces phosphorylation and nuclear translocation of ferritin heavy chain
    Runsheng Li
    Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai 200025, People s Republic of China
    J Biol Chem 281:37616-27. 2006
    ..In the present study, we demonstrate that the CXC chemokine receptor 4 (CXCR4) formed a complex with ferritin heavy chain (FHC) in a ligand-dependent manner...
  58. ncbi Highly focused clonal composition of CD8(+) CD28(neg) T cells in aqueous humor of fuchs heterochromic cyclitis
    Pierre Labalette
    Service d Ophtalmologie, EA 2686, Centre Hospitalier et Universitaire de Lille, 59045, Lille, France
    Exp Eye Res 75:317-25. 2002
    Fuchs heterochromic cyclitis (FHC) is characterized by a predominant CD8(+) T cell subset infiltrating the anterior chamber, but the clonal composition of these T cells is unknown...
  59. ncbi Effects of lumbar spinal fusion on the other lumbar intervertebral levels (three-dimensional finite element analysis)
    Keisuke Goto
    Department of Orthopaedic Surgery, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, 889 1692, Japan
    J Orthop Sci 8:577-84. 2003
    ..We compared intact, L4/5 posterior interbody fusion (PLF), and L4/5 posterior lumbar interbody fusion (PLIF) models...
  60. doi Photoelectrochemical biosensing platform for microRNA detection based on in situ producing electron donor from apoferritin-encapsulated ascorbic acid
    Huanshun Yin
    College of Chemistry and Material Science, Shandong Agricultural University, 271018 Taian, Shandong, PR China
    Biosens Bioelectron 53:175-81. 2014
    ..DNA as detecting probe, streptavidin as signal capturing unit and biotin functionalized ascorbic acid loaded apoferritin as signal amplification unit...
  61. doi Intramuscular pressure of the multifidus muscle and low-back pain after posterior lumbar interbody fusion: comparison of mini-open and conventional approaches
    Yoshihiro Mukai
    Department of Orthopedic Surgery, Osaka Kosei Nenkin Hospital, Fukushima, Osaka and
    J Neurosurg Spine 19:651-7. 2013
    ..the perioperative development of intramuscular multifidus muscle pressure after posterior lumbar interbody fusion (PLIF) and to investigate whether the route of pedicle screw insertion affects this pressure and resultant low-back pain...
  62. doi H-ferritin overexpression promotes radiation-induced leukemia/lymphoma in mice
    Sumitaka Hasegawa
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Carcinogenesis 33:2269-75. 2012
    ..Our findings indicate that HF overexpression is closely related to the development of leukemia/lymphoma, which could have implications for the prevention of malignant hematologic diseases...
  63. pmc Hyperferritinemia and hyperuricemia may be associated with liver function abnormality in obese adolescents
    Solomon Chih Cheng Chen
    Department of Pediatrics, Chia Yi Christian Hospital, Chia Yi City, Taiwan
    PLoS ONE 7:e48645. 2012
    ..The objective was to investigate the association among the levels of serum ferritin, uric acid and alanine aminotransferase (ALT) in adolescents...
  64. pmc KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis
    Isabel Wong-Baeza
    Nuffield Department of Rheumatological and Musculoskeletal Sciences, Botnar Research Centre, Oxford OX3 7LD, United Kingdom
    J Immunol 190:3216-24. 2013
    ..expressed at the cell surface of APC as both classical β2-microglobulin-associated B27 and B27 free H chain forms (FHC), including disulfide-bonded H chain homodimers (termed B27(2))...
  65. ncbi Oxidative stress levels in myelodysplastic syndrome patients: their relationship to serum ferritin and haemoglobin values
    K Saigo
    Faculty of Pharmacological Sciences, Himeji Dokkyo University, 7 Kami ohno, Himeji, Hyogo 670 8524, Japan
    J Int Med Res 39:1941-5. 2011
    ..The results indicated that iron accumulation or severe anaemia could contribute to oxidative stress in MDS patients. Iron chelation and antioxidant therapy may be suitable for the management of MDS...
  66. pmc Long-range effects of familial hypertrophic cardiomyopathy mutations E180G and D175N on the properties of tropomyosin
    Socheata Ly
    Cardiovascular Program, Boston Biomedical Research Institute, 64 Grove Street, Watertown, MA 02472, USA
    Biochemistry 51:6413-20. 2012
    Cardiac α-tropomyosin (Tm) single-site mutations D175N and E180G cause familial hypertrophic cardiomyopathy (FHC)...
  67. doi Structural analysis of haemin demetallation by L-chain apoferritins
    Natalia de Val
    Institute of Life Sciences, University of Louvain, Place Croix du Sud, 1348 Louvain la Neuve, Belgium
    J Inorg Biochem 112:77-84. 2012
    ..In vitro experiments had shown that horse spleen apoferritin or recombinant horse L chain apoferritins, when co-crystallised with haemin, undergoes demetallation of the ..
  68. ncbi Familial hypertrophic cardiomyopathy mutations in troponin I (K183D, G203S, K206Q) enhance filament sliding
    Jan Kohler
    Molekular und Zellphysiologie, Medizinische Hochschule, D 30625 Hannover, Germany
    Physiol Genomics 14:117-28. 2003
    A major cause of familial hypertrophic cardiomyopathy (FHC) is dominant mutations in cardiac sarcomeric genes...
  69. ncbi Comparison of clinical and radiological results of posterolateral fusion, posterior lumbar interbody fusion and transforaminal lumbar interbody fusion techniques in the treatment of degenerative lumbar spine
    Z Audat
    Orthopaedic Department, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
    Singapore Med J 53:183-7. 2012
    ..treatment, such as posterolateral fusion and posterior instrumentation (PLF), posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF)...
  70. pmc Efficiency of ferritin as an MRI reporter gene in NPC cells is enhanced by iron supplementation
    Yupeng Feng
    State Key Laboratory of Oncology in Southern China, Imaging Diagnosis and Interventional Center, Cancer Center, Sun Yat Sen University, 651 Dongfeng Road East, Guangzhou, China
    J Biomed Biotechnol 2012:434878. 2012
    An emerging MRI reporter, ferritin heavy chain (FTH1), is recently applied to enhance the contrast and increase the sensitivity of MRI in the monitoring of solid tumors...
  71. doi Ab initio study of the solvent H-bonding effect on ESIPT reaction and electronic transitions of 3-hydroxychromone derivatives
    Cyril A Kenfack
    Laboratoire de Biophotonique et Pharmacologie, UMR 7213 du CNRS, Faculte de Pharmacie, Universite de Strasbourg, 74, route du Rhin, 67401 Illkirch Cedex, France
    Phys Chem Chem Phys 14:8910-8. 2012
    ..electronic transitions occurring in 4-(N,N-dimethylamino)-3-hydroxyflavone (DMAF) and 2-furanyl-3-hydroxychromone (FHC) were investigated using the TDDFT method in aprotic and protic solvents...
  72. ncbi Comparison of skeletal muscle mass to fat-free mass ratios among different ethnic groups
    T Abe
    Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA
    J Nutr Health Aging 16:534-8. 2012
    ..e., SMM / height square or SMM to fat-free mass (FFM) ratio, differs among different ethnic groups at the same level of body mass index (BMI)...
  73. doi Risk factors for cage retropulsion after posterior lumbar interbody fusion: analysis of 1070 cases
    Hiroaki Kimura
    Department of Orthopedic Surgery, Gakkentoshi Hospital, Kyoto, Japan
    Spine (Phila Pa 1976) 37:1164-9. 2012
    ..Single-center retrospective study...
  74. doi The universal mechanism for iron translocation to the ferroxidase site in ferritin, which is mediated by the well conserved transit site
    Taro Masuda
    Laboratory of Food Quality Design and Development, Division of Agronomy and Horticultural Science, Graduate School of Agriculture, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
    Biochem Biophys Res Commun 400:94-9. 2010
    ..These results suggest that the conserved transit site also has a function to assist with the metal ion sequestration to the ferroxidase site in ferritins from vertebrates...
  75. doi Effect of intraoperative position used in posterior lumbar interbody fusion on the maintenance of lumbar lordosis
    Jae Hyup Lee
    Department of Orthopedic Surgery, Seoul National University Medical College, Seoul National University Boramae Hospital, Seoul, Korea
    J Neurosurg Spine 8:263-70. 2008
    ..study was to compare retrospectively the use of different operating tables with different positions for posterior lumbar interbody fusion (PLIF) and the effect on intraoperative and postoperative lumbar lordosis and segmental lordosis.
  76. doi Role of ferritin alterations in human breast cancer cells
    Svitlana I Shpyleva
    Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Breast Cancer Res Treat 126:63-71. 2011
    ..phenotype, such as MCF-7, MDA-MB-361, T-47D, HCC70 and cells, expressed low levels of ferritin light chain, ferritin heavy chain, transferrin, transferring receptor, and iron-regulatory proteins 1 and 2...
  77. doi Comparison of posterolateral fusion with and without additional posterior lumbar interbody fusion for degenerative lumbar spondylolisthesis
    Kee Yong Ha
    Department of Orthopaedic Surgery, Kang Nam St Mary s Hospital, College of Medicine, The Catholic University of Korea, Seoul
    J Spinal Disord Tech 21:229-34. 2008
    ..The authors retrospectively studied the effects of posterior lumbar interbody fusion (PLIF) after PLF for the treatment of DS.
  78. doi Characterization of horse spleen apoferritin reactive lysines by MALDI-TOF mass spectrometry combined with enzymatic digestion
    Qingbing Zeng
    Department of Chemistry and Biochemistry and Nanocenter, University of South Carolina, 631 Sumter Street, Columbia, SC 29208, USA
    Bioorg Chem 36:255-60. 2008
    ..Recently, ferritin and apoferritin (ferritin devoid of the iron core), have been employed as chemically addressable nanoscale building blocks for ..
  79. doi Neutron spin echo studies on ferritin: free-particle diffusion and interacting solutions
    Wolfgang Häussler
    FRM II and E21, Technische Universitat Munchen, Garching, Germany
    Eur Biophys J 37:563-71. 2008
    ..In this article, a systematic study of diffusive dynamics of ferritin and apoferritin (=ferritin without iron core) is presented...
  80. doi Comparative study of unilateral and bilateral cages with respect to clinical outcomes and stability in instrumented posterior lumbar interbody fusion
    Ji Ho Lee
    Department of Orthopedic Surgery, Seoul National University Medical College, Seoul Metropolitan Government, Seoul National University, Boramae Medical Center, Seoul, Korea
    Neurosurgery 63:109-13; discussion 113-4. 2008
    We sought to compare the clinical and radiological results of instrumented posterior lumbar interbody fusion (PLIF) using unilateral or bilateral polyetheretherketone cages and pedicle screws.
  81. doi Anharmonic behavior in the multisubunit protein apoferritin as revealed by quasi-elastic neutron scattering
    Mark T F Telling
    ISIS Facility, Science and Technology Facilities Council STFC, Rutherford Appleton Laboratory, Chilton, OX11 OQX, UK
    J Phys Chem B 112:10873-8. 2008
    ..QENS) has been used to study the deviation from Debye-law harmonic behavior in lyophilized and hydrated apoferritin, a naturally occurring, multisubunit protein...
  82. doi Electrochemical detection of DNA hybridization based on signal DNA probe modified with Au and apoferritin nanoparticles
    Fengli Yu
    State Key Laboratory Base of Eco chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
    Biosens Bioelectron 26:1114-7. 2010
    ..approach for sequence-specific DNA detection based on signal dual-amplification with Au NPs and marker-loaded apoferritin NPs was reported...
  83. doi Biomechanical comparison between lumbar disc arthroplasty and fusion
    Shih Hao Chen
    Department of Orthopaedics, Tzu Chi General Hospital, Taichung, Taiwan
    Med Eng Phys 31:244-53. 2009
    ..to either insert an artificial disc (ProDisc II; ADR) or incorporate bilateral posterior lumbar interbody fusion (PLIF) cages with a pedicle screw fixation system...
  84. doi Posterior lumbar interbody fusion versus posterolateral fusion with instrumentation in the treatment of low-grade isthmic spondylolisthesis: midterm clinical outcomes
    Ahmet Murat Musluman
    Clinic of Neurosurgery, Sisli Etfal Education and Research Hospital, Istanbul, Turkey
    J Neurosurg Spine 14:488-96. 2011
    The purpose of this study was to compare the methods of posterior lumbar interbody fusion (PLIF) and posterolateral fusion (PLF) in cases of isthmic Grades 1 and 2 lumbar spondylolisthesis, and to evaluate the clinical efficacy of the ..
  85. pmc TLIF for symptomatic disc degeneration: a retrospective study of 100 patients
    Pier Paolo Mura
    Eur Spine J 20:S57-60. 2011
    ..been described such as combined anterior-posterior fusion (APF), instrumented posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF)...
  86. doi Preventive effect of artificial ligamentous stabilization on the upper adjacent segment impairment following posterior lumbar interbody fusion
    Shiro Imagama
    Department of Orthopedic Surgery, Nagoya University School of Medicine, Japan
    Spine (Phila Pa 1976) 34:2775-81. 2009
    ..A retrospective, comparative study...
  87. doi Up-regulation of ferritin ubiquitination in skeletal muscle of transgenic rats bearing the G93A hmSOD1 gene mutation
    Malgorzata Halon
    Department of Bioenergetics and Physiology of Exercise, Medical University of Gdansk, Poland
    Neuromuscul Disord 20:29-33. 2010
    ..Our data show for the first time that ferritin ubiquitination could be responsible for oxidative stress in muscles of rats bearing the G93A hmSOD1, consequently ferritin is not able to control the labile iron pool...
  88. pmc Stand-alone cage for posterior lumbar interbody fusion in the treatment of high-degree degenerative disc disease: design of a new device for an "old" technique. A prospective study on a series of 116 patients
    Francesco Costa
    Neurosurgery Department, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy
    Eur Spine J 20:S46-56. 2011
    ..In recent years, many possible surgical fusion techniques have been introduced; PLIF is one of these...
  89. doi Posterior versus anterior lumbar interbody fusion with anterior tension band plating: retrospective analysis
    Curt Freudenberger
    SportsMed, Huntsville, Alabama, USA
    Orthopedics 32:492. 2009
    Over the past 2 decades, posterior lumbar interbody fusion (PLIF) with pedicle screw instrumentation has gained popularity...
  90. pmc Mesangial cell complement receptor 1-related protein y limits complement-dependent neutrophil accumulation in immune complex glomerulonephritis
    Lihua Bao
    The University of Chicago, Chicago, IL 60637, USA
    Immunology 128:e895-904. 2009
    ..After 3 weeks of immunization with horse spleen apoferritin, six of nine Crry(-/-) C3(+/-) mice and none of the six control C3(+/-) mice developed proliferative GN (P = 0...
  91. doi Computational studies on the interactions of inhalational anesthetics with proteins
    Satyavani Vemparala
    The Institute of Mathematical Sciences, C I T Campus, Taramani, Chennai 600 113, India
    Acc Chem Res 43:103-10. 2010
    ..However, later experiments with lipid-free globular proteins, such as luciferase and apoferritin, shifted the focus of anesthetic action to proteins...
  92. doi Extrapulmonary tuberculosis in Kabul, Afghanistan: a hospital-based retrospective review
    Tim Fader
    CURE International Hospital, PO Box 621, Darulaman Rd, near King s Palace, Karte Se, Kabul, Afghanistan
    Int J Infect Dis 14:e102-10. 2010
    ..The purpose of this study is to amplify the knowledge base of the epidemiology, symptoms, and signs of extrapulmonary tuberculosis (EPTB) in Afghanistan...
  93. doi Hemostatic and electrolyte effects of hydroxyethyl starches in patients undergoing posterior lumbar interbody fusion using pedicle screws and cages
    Soo Joo Choi
    Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Spine (Phila Pa 1976) 35:829-34. 2010
    ..Prospective, randomized, double blind, clinical study...
  94. doi Biomechanical evaluation of an expandable cage in single-segment posterior lumbar interbody fusion
    Nitin N Bhatia
    Orthopaedic Biomechanics Laboratory, VA Healthcare System, Long Beach, California 90822, USA
    Spine (Phila Pa 1976) 37:E79-85. 2012
    ..Controlled laboratory study...
  95. doi Perioperative complications of primary posterior lumbar interbody fusion for nonisthmic spondylolisthesis: analysis of risk factors
    Noboru Hosono
    Department of Orthopaedic Surgery, Osaka Kosei Nenkin Hospital, Fukushima, Osaka, Japan
    J Neurosurg Spine 9:403-7. 2008
    Although posterior lumbar interbody fusion (PLIF) is an excellent procedure to attain circumferential decompression, it is technically demanding and can lead to various surgical complications...
  96. doi Comparison of paraspinal muscle injury in one-level lumbar posterior inter-body fusion: modified minimally invasive and traditional open approaches
    Shun wu Fan
    Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Institute of Micro Invasive Surgery of Zhejiang University, Hangzhou, China
    Orthop Surg 2:194-200. 2010
    To determine differences in paraspinal muscle injury between a modified minimally invasive approach (MMIA) and a traditional operative approach (TOPA) for one-level instrumented posterior lumbar inter-body fusion (PLIF).
  97. pmc Patient interest in recording family histories of cancer via the Internet
    Christian Simon
    Department of Bioethics, Case Western Reserve University, Cleveland, Ohio, USA
    Genet Med 10:895-902. 2008
    This study investigated the interest of mammogram patients in using electronic tools for recording their family histories of cancer (FHC).
  98. pmc Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein
    Robert D Gaffin
    Department of Physiology and Biophysics, Center for Cardiovascular Research, University of Illinois at Chicago, IL 60612, USA
    J Mol Cell Cardiol 51:812-20. 2011
    ..transiently improves relaxation and delays hypertrophic remodeling in a familial hypertrophic cardiomyopathy (FHC) caused by a mutation in the thin filament protein, tropomyosin (i.e., α-TmE180G or Tm180)...
  99. ncbi Radiographic characteristics on conventional radiographs after posterior lumbar interbody fusion: comparative study between radiotranslucent and radiopaque cages
    O Diedrich
    Department of Orthopaedic Surgery, University of Bonn, Bonn, Germany
    J Spinal Disord 14:522-32. 2001
    ..Our purpose is to evaluate radiographic findings after posterior lumbar interbody fusion (PLIF) with cages and estimate their relative value in judging fusion status...
  100. pmc Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration
    Barry B Muhoberac
    Department of Chemistry and Chemical Biology, Indiana University Purdue University, Indianapolis, IN 46202, USA
    Biochim Biophys Acta 1812:544-8. 2011
    ..Ferritin IBs are composed of mutant ferritin light chain as well as wild-type light (Wt-FTL) and heavy chain (FTH1) polypeptides. In vitro studies have shown that the mutant light chain polypeptide p...

Research Grants80

  1. Single Cross-Bridge Kinetics in Transgenic Mouse Hearts Expressing FHC Mutations
    Danuta Szczesna Cordary; Fiscal Year: 2010
    Familial hypertrophic cardiomyopathy (FHC) is an autosomal dominant disease originating from mutations in genes that encode for the major contractile proteins of the heart, including the ventricular myosin regulatory (RLC) and ..
  2. Arrhythmia Mechanisms in Sarcomeric Cardiomyopathies
    BJORN C contact KNOLLMANN; Fiscal Year: 2010
    Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal-dominant disease resulting from mutations in genes encoding sarcomeric proteins...
  3. The Role of the Proteasome in Troponin related Cardiomyopathies
    ALDRIN VERNO GOMES; Fiscal Year: 2010
    ..Mutations in cardiac troponin T (cTnT) are responsible for ~7% of all familial hypertrophic cardiomyopathy (FHC) cases...
  4. In Situ Sensing of Single Myosin Function in Hypertrophy Disease
    Thomas P Burghardt; Fiscal Year: 2010
    ..cardiac myosin heavy chain (MHC) and both of its light chains (MLCs) harbor familial hypertrophic cardiomyopathy (FHC)-linked mutations. MHC mutants are hypothesized to disrupt specific transduction pathways...
  5. Troponin and myosin in regulation of muscle contraction and heart disease
    Zenon Grabarek; Fiscal Year: 2010
    A number of familial hypertrophic cardiomyopathy (FHC) causing mutations have been identified in the regulatory proteins, tropomyosin (Tm) and troponin (Tn)...
  6. Troponin and myosin in regulation of muscle contraction and heart disease
    Zenon Grabarek; Fiscal Year: 2011
    A number of familial hypertrophic cardiomyopathy (FHC) causing mutations have been identified in the regulatory proteins, tropomyosin (Tm) and troponin (Tn)...
  7. Spectroscopy of myosin light chain domain dynamics
    Osha Roopnarine; Fiscal Year: 2010
    ..how this is altered in muscle disease, focusing on LC mutations that cause familial hypertrophic cardiomyopathy (FHC)...
  8. Spectroscopy of myosin light chain domain dynamics
    Osha Roopnarine; Fiscal Year: 2007
    ..how this is altered in muscle disease, focusing on LC mutations that cause familial hypertrophic cardiomyopathy (FHC)...
  9. EFFECT OF CARDIOMYOPATHY MUTATIONS ON MYOSIN AND ACTIN
    KATHLEEN TRYBUS; Fiscal Year: 2004
    ..the beta-cardiac myosin heavy chain and in alpha-cardiac actin lead to either familial hypertrophic cardiomyopathy (FHC) or dilated cardiomyopathy (DCM)...
  10. FHC Tn Mutations: Functional Consequences & Mechanisms
    James Potter; Fiscal Year: 2005
    Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal dominant disease, which has been associated with mutations in almost every major cardiac sarcomeric protein...
  11. THIN FILAMENTS WITH CARDIOMYOPATHIC MUTANT PROTEINS
    LARRY TOBACMAN; Fiscal Year: 2003
    DESCRIPTION (adapted from the applicant's description): Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal dominant disorder caused by mutations in any of several genes encoding the proteins of the cardiac contractile apparatus...
  12. Molecular mechanics of mutant cardiac myosin
    Jeffrey R Moore; Fiscal Year: 2010
    The cardiac hypertrophy, myofibrillar disarray and sudden death caused by familial hypertrophic cardiomyopathy (FHC) results from autosomal dominant mutations in sarcomeric proteins...
  13. MECHANISM OF CARDIAC MUSCLE REGULATION BY TROPONIN
    James Potter; Fiscal Year: 2006
    ..of cardiac muscle contraction by troponin and to determine its role in familial hypertrophic cardiomyopathy (FHC). SPECIFIC AIM 1. Cardiac TnT (CTnT) Isoforms and the Regulation of Contraction...
  14. MECHANISM OF CARDIAC MUSCLE REGULATION BY TROPONIN
    James Potter; Fiscal Year: 2002
    ..muscle contraction by troponin and to determine its role in the genesis of familial hypertrophic cardiomyopathy (FHC). There are two major projects: In I...
  15. REGULATION OF CONTRACTION IN MUSCLE AND NONMUSCLE CELLS
    Sarah Hitchcock DeGregori; Fiscal Year: 2002
    ..4. To determine the structure of the N-terminal, tropomyosin-binding, regulatory domain of human cardiac TnT, and the effect of FHC mutations on its structure and function.
  16. Cardiac Troponin in Health and Disease
    JAMES DOUGLAS POTTER; Fiscal Year: 2010
    ..will determine the effect of mutations in cTnT, cTnI and cTnC, known to cause familial hypertrophic cardiomyopathy (FHC or HCM), dilated cardiomyopathy (DCM) and restrictive cardiomyopathy (RCM) on the biochemical, contractile and ..
  17. Cardiac Troponin in Health and Disease
    James Potter; Fiscal Year: 2009
    ..will determine the effect of mutations in cTnT, cTnI and cTnC, known to cause familial hypertrophic cardiomyopathy (FHC or HCM), dilated cardiomyopathy (DCM) and restrictive cardiomyopathy (RCM) on the biochemical, contractile and ..
  18. Troponin T mutations and Sudden Cardiac Death
    Bjorn Knollmann; Fiscal Year: 2006
    Familial Hypertrophic Cardiomyopathy (FHC) is an autosomal-dominant disease resulting from mutations in genes encoding cardiac contractile proteins, and an important cause of Sudden Cardiac Death (SCD)...
  19. Allele-specific Effects: Single Amino Acid Exchanges/cTnT
    JIL TARDIFF; Fiscal Year: 2007
    ..in cardiac Troponin T (cTnT) result in a particularly severe form of Familial Hypertrophic Cardiomyopathy (FHC) characterized by a high frequency of early sudden cardiac death in the absence of overt ventricular hypertrophy...
  20. Deep Brain Microelectrode Array For Functional Neurosurgery
    JAMILLE HETKE; Fiscal Year: 2007
    ..NeuroNexus, Inc. is leading the project in collaboration with FHC, Inc., the University of Michigan and consultants from the Cleveland Clinic...
  21. Structural Comparison of Strongly-Bound Actomyosin States
    Dorit Hanein; Fiscal Year: 2009
    ..One prime cause of heart disease is familial hypertrophic cardiomyopathy (FHC), which is an inherited cardiac disease that frequently results in sudden death of young and otherwise healthy ..
  22. Deep Brain Stimulation Array for Neuromodulation
    RIO VETTER; Fiscal Year: 2007
    ..NeuroNexus is leading this project in collaboration with FHC, the University of Michigan and consultants from the Cleveland Clinic...
  23. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ..Coregulation of ferritin mRNAs, FTH and FTL, with iron trafficking proteins depends on a group of mRNA structures, the iron regulatory element (IRE) ..
  24. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    Elizabeth Theil; Fiscal Year: 2009
    ..Coregulation of ferritin mRNAs, FTH and FTL, with iron trafficking proteins depends on a group of mRNA structures, the iron regulatory element (IRE) ..
  25. Ferritin: Protein/mRNA/DNA in Fe/O Regulation/Metabolism
    ELIZABETH C contact THEIL; Fiscal Year: 2010
    ..Coregulation of ferritin mRNAs, FTH and FTL, with iron trafficking proteins depends on a group of mRNA structures, the iron regulatory element (IRE) ..
  26. Calcium regulation of cardiac thin filament activation
    Murali Chandra; Fiscal Year: 2007
    ..Furthermore, FHC-related cTnT mutants will be used to understand how modifications to the N and C termini of cTnT contribute to ..