FTH1

Summary

Gene Symbol: FTH1
Description: ferritin heavy chain 1
Alias: FHC, FTH, FTHL6, HFE5, PIG15, PLIF, ferritin heavy chain, apoferritin, cell proliferation-inducing gene 15 protein, ferritin H subunit, ferritin, heavy polypeptide 1, placenta immunoregulatory factor, proliferation-inducing protein 15
Species: human
Products:     FTH1

Top Publications

  1. Han L, Batistel F, Ma Y, Alharthi A, Parys C, Loor J. Methionine supply alters mammary gland antioxidant gene networks via phosphorylation of nuclear factor erythroid 2-like 2 (NFE2L2) protein in dairy cows during the periparturient period. J Dairy Sci. 2018;101:8505-8512 pubmed publisher
    ..glutathione reductase (GSR), glutathione peroxidase 1 (GPX1), malic enzyme 1 (ME1), ferrochelatase (FECH), ferritin heavy chain 1 (FTH1), and NAD(P) H quinone dehydrogenase 1 (NQO1) in the mammary tissue...
  2. Chekhun V, Lozovska Y, Naleskina L, Borikun T, Burlaka A, Todor I, et al. Modifying effects of 5-azacytidine on metal-containing proteins profile in Guerin carcinoma with different sensitivity to cytostatics. Exp Oncol. 2016;38:283-287 pubmed
    ..The study has shown that 5-aza treatment caused demethylation of promoter regions of fth1 and tfr1 genes in all studied Guerin carcinoma strains...
  3. Wang C, Chen Y, Lee Y, Chang J. Endoplasmic reticulum stress contributes to ferritin molecules-mediated macrophage migration via P-selectin glycoprotein ligand-1. Mol Nutr Food Res. 2017;61: pubmed publisher
    ..01). An in vitro study revealed that serum ferritin and apoferritin induced tumor necrosis factor-? and sPSGL-1 secretion (all p < 0.01)...
  4. Elbaz M, Yanay N, Laban S, Rabie M, Mitrani Rosenbaum S, Nevo Y. Life or death by NFκB, Losartan promotes survival in dy2J/dy2J mouse of MDC1A. Cell Death Dis. 2015;6:e1690 pubmed publisher
    ..factor 1 (TRAF1), TNF receptor-associated factor 2 (TRAF2), cellular inhibitor of apoptosis (cIAP2), and Ferritin heavy chain (FTH1) were increased following Losartan treatment...
  5. Shpyleva S, Pogribna M, Cozart C, Bryant M, Muskhelishvili L, Tryndyak V, et al. Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism. J Nutr Biochem. 2014;25:1235-42 pubmed publisher
    ..increase in the expression of iron metabolism genes, especially transferrin receptor (Tfrc), ferritin heavy chain (Fth1), and solute carrier family 40 (iron-regulated transporter), member 1 (Slc40a1, Fpn1) and their ..
  6. Obakan Yerlikaya P, Arisan E, Coker Gurkan A, Adacan K, Özbey U, Somuncu B, et al. Calreticulin is a fine tuning molecule in epibrassinolide-induced apoptosis through activating endoplasmic reticulum stress in colon cancer cells. Mol Carcinog. 2017;56:1603-1619 pubmed publisher
    ..Furthermore, 48?h EBR treatment did not caused UPR in Fetal Human Colon cells (FHC) and Mouse Embryonic Fibroblast cells (MEF)...
  7. Funauchi Y, Tanikawa C, Yi Lo P, Mori J, Daigo Y, Takano A, et al. Regulation of iron homeostasis by the p53-ISCU pathway. Sci Rep. 2015;5:16497 pubmed publisher
    ..1 (IRP1), a cytosolic Fe-S protein, to an iron-responsive element in the 5' UTR of ferritin heavy polypeptide 1 (FTH1) mRNA and subsequently reduced the translation of FTH1, a major iron storage protein...
  8. Marques L, Negre Salvayre A, Costa L, Canonne Hergaux F. Iron gene expression profile in atherogenic Mox macrophages. Biochim Biophys Acta. 2016;1862:1137-46 pubmed publisher
    ..Expression of ferroportin (Slc40a1, alias Fpn), heme oxygenase-1 (Hmox1), H- and L-ferritin (Fth1 and Ftl1), hepcidin (Hamp), ceruloplasmin (Cp) and interleukine-6 (Il6) was followed by quantitative PCR...
  9. Zhao H, Zhao X, Lei T, Zhang M. Screening, identification of prostate cancer urinary biomarkers and verification of important spots. Invest New Drugs. 2019;: pubmed publisher
    ..The ferritin heavy chain (FTH) gene, ferritin light chain (FTL) gene and protein expression of BPH-1 cells and PC-3 cells were ..

More Information

Publications148 found, 100 shown here

  1. Wang Q, Chuikov S, Taitano S, Wu Q, Rastogi A, Tuck S, et al. Dimethyl Fumarate Protects Neural Stem/Progenitor Cells and Neurons from Oxidative Damage through Nrf2-ERK1/2 MAPK Pathway. Int J Mol Sci. 2015;16:13885-907 pubmed publisher
    ..SuperArray gene screen technology to identify additional anti-oxidative stress genes (Gstp1, Sod2, Nqo1, Srxn1, Fth1)...
  2. Biggar K, Wu C, Tessier S, Zhang J, Pifferi F, Perret M, et al. Modulation of Gene Expression in Key Survival Pathways During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus. Genomics Proteomics Bioinformatics. 2015;13:111-8 pubmed publisher
    ..tissues showed elevated gene expression of peroxisome proliferator activated receptor gamma (ppargc), ferritin (fth1), and protein chaperones during torpor...
  3. Ishaq M, Evans M, Ostrikov K. Atmospheric pressure gas plasma-induced colorectal cancer cell death is mediated by Nox2-ASK1 apoptosis pathways and oxidative stress is mitigated by Srx-Nrf2 anti-oxidant system. Biochim Biophys Acta. 2014;1843:2827-37 pubmed publisher
    ..cells (human colonic sub-epithelial myofibroblasts; CO18, human fetal lung fibroblast; MRC5 and fetal human colon; FHC). However, the identity of an oxidase participating in AGP-induced cancer cell death is unknown...
  4. Sun S, Cheng S, Zhu Y, Zhang P, Liu N, Xu T, et al. Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells. Gene. 2016;584:90-6 pubmed publisher
    ..Transient knockdown of PRKDC reduced cell proliferation/survival in HCT116 and DLD1, but not FHC cells...
  5. Nikodemova M, Yee J, Carney P, Bradfield C, Malecki K. Transcriptional differences between smokers and non-smokers and variance by obesity as a risk factor for human sensitivity to environmental exposures. Environ Int. 2018;113:249-258 pubmed publisher
    ..vs non-smokers for four DNA damage related genes (GADD45A, DDB2, RAD51 and P53), two oxidative stress genes (FTH1, TXN), two hypoxia response genes (BN1P3lL, ARNT), and one gene associated with unfolded protein response (ATF6B)...
  6. Simão M, Camacho A, Ostertag A, Cohen Solal M, Pinto I, Porto G, et al. Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis. PLoS ONE. 2018;13:e0207441 pubmed publisher
    ..by the observed downregulation of bone metabolism markers and upregulation of ferritin heavy polypeptide 1 (Fth1) and transferrin receptor-1 (Tfrc), which are associated with iron toxicity and bone loss phenotype...
  7. Lee Y, Lau Y, Ng K, Lai W, Ho S, Tse H, et al. Efficient attenuation of Friedreich's ataxia (FRDA) cardiomyopathy by modulation of iron homeostasis-human induced pluripotent stem cell (hiPSC) as a drug screening platform for FRDA. Int J Cardiol. 2016;203:964-71 pubmed publisher
    ..iron-response protein (IRP-1) regulatory loop was overridden by DFP as reflected by resumed level of ferritin (FTH) back to basal level and the attenuated transferrin receptor (TSFR) mRNA level suppression thereby reducing further ..
  8. Kong Z, Liu R, Cheng Y. Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother. 2019;109:2043-2053 pubmed publisher
    ..light chain 3), Atg3, Atg5, Atg6/beclin1, Atg12 (autophagy related genes) and down-regulation of p62, FTH1 (ferritin heavy chain), NCOA4 (nuclear receptor co-activator 4) in activated HSCs...
  9. Qiu L, Lin J, Liu Q, Wang S, Lv G, Li K, et al. The Role of the Hydroxyl Group in Propofol-Protein Target Recognition: Insights from ONIOM Studies. J Phys Chem B. 2017;121:5883-5896 pubmed publisher
    ..human serum albumin (HSA), the pH-gated ion channel from Gloeobacter violaceus (GLIC), and horse spleen apoferritin (HSAF), were investigated systematically by using a rigorous three-layer ONIOM (M06-2X/6-31+G*:PM6:AMBER) ..
  10. Davis W, Boyd J, Ile K, Tew K. Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. Biochim Biophys Acta. 2004;1683:89-100 pubmed
    ..Addition of progesterone or U18666A to CHO cells elevated ABCA2 expression. Finally, we found that ABCA2 expression was elevated in Niemann-Pick type C1 (NPC1) fibroblasts and in Familial Hypercholesterolemia (FHC) fibroblasts.
  11. Cheng H, Yen C, Chang C, Huang K, Chen K, Zhang R, et al. Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress. Biochim Biophys Acta. 2015;1850:2506-17 pubmed publisher
    ..Here we establish a functional connection between ferritin heavy chain (FHC) and HO-1. In human lupus nephritis HO-1 and FHC are colocalized within the glomeruli...
  12. Okuda S, Sufu Shimizu Y, Kato T, Fukuda M, Nishimura S, Oda T, et al. CaMKII-mediated phosphorylation of RyR2 plays a crucial role in aberrant Ca2+ release as an arrhythmogenic substrate in cardiac troponin T-related familial hypertrophic cardiomyopathy. Biochem Biophys Res Commun. 2018;496:1250-1256 pubmed publisher
    Cardiac Troponin T (TnT) mutation-linked familial hypertrophic cardiomyopathy (FHC) is known to cause sudden cardiac death at a young age...
  13. Hu H, Chen L, Frary C, Chang C, Hui H, Zhang H, et al. The beneficial effect of Batroxobin on blood loss reduction in spinal fusion surgery: a prospective, randomized, double-blind, placebo-controlled study. Arch Orthop Trauma Surg. 2015;135:491-7 pubmed publisher
    ..The use of Batroxobin for patients undergoing one-level PLIF surgery safely and effectively reduced the total amount of perioperative blood loss.
  14. Alileche A, Hampikian G. The effect of Nullomer-derived peptides 9R, 9S1R and 124R on the NCI-60 panel and normal cell lines. BMC Cancer. 2017;17:533 pubmed publisher
    ..and the hematopoietic system), and four normal cell lines (endothelial HUVEC, skin fibroblasts BJ, colon epithelial FHC and normal prostate RWPE-1)...
  15. Buranrat B, Connor J. Cytoprotective effects of ferritin on doxorubicin-induced breast cancer cell death. Oncol Rep. 2015;34:2790-6 pubmed publisher
    ..The impact of decreasing ferritin light chain (FTL) and ferritin heavy chain (FTH) expression on doxorubicin sensitivity was assessed using siRNA...
  16. Pouliot B, Jbel M, Mercier A, Labbe S. abc3+ encodes an iron-regulated vacuolar ABC-type transporter in Schizosaccharomyces pombe. Eukaryot Cell. 2010;9:59-73 pubmed publisher
    ..Because S. pombe does not possess vacuolar membrane-localized orthologs to S. cerevisiae Fth1, Fet5, and Smf3, our findings suggested that Abc3 may be responsible for mobilizing stored iron from the vacuole to ..
  17. Jung I, Choi S, Jung J, Lee S, Han S, Kim H, et al. Involvement of iron depletion in palmitate-induced lipotoxicity of beta cells. Mol Cell Endocrinol. 2015;407:74-84 pubmed publisher
    ..with palmitate reduced the level of transferrin receptor 1 (TfR1), but increased the level of heavy chain ferritin (FTH). In addition, palmitate reduced intracellular labile iron pool...
  18. Pizzamiglio S, De Bortoli M, Taverna E, Signore M, Veneroni S, Cho W, et al. Expression of Iron-Related Proteins Differentiate Non-Cancerous and Cancerous Breast Tumors. Int J Mol Sci. 2017;18: pubmed publisher
    ..88 (MYD88), CD74, iron exporter ferroportin (FPN), high mobility group box 1 (HMGB1), STAT3_pS727, TFRC, ferritin heavy chain (FTH), and ferritin light chain (FTL)...
  19. Johnson A, Delrow J, Zager R. Tin protoporphyrin activates the oxidant-dependent NRF2-cytoprotective pathway and mitigates acute kidney injury. Transl Res. 2017;186:1-18 pubmed publisher
    ..action; (2) GSH treatment blunted SnPP's protective influence; (3) SnPP raised cytoprotective heavy chain ferritin (Fhc), a response enhanced by exogenous Fe injection; and (4) SnCl2, a ∼35- to 50-fold HO-1 inducer (not ..
  20. Lin S, Lee D, Wang H, Kang S, Hwang P, Kou G, et al. White spot syndrome virus protein kinase 1 defeats the host cell's iron-withholding defense mechanism by interacting with host ferritin. J Virol. 2015;89:1083-93 pubmed publisher
    ..27-MHz quartz crystal microbalance (QCM) analysis confirmed the interaction between PK1 and both ferritin and apoferritin. PK1 did not promote the release of iron ions from ferritin, but it prevented apoferritin from binding ferrous ..
  21. Crisà A, Ferré F, Chillemi G, Moioli B. RNA-Sequencing for profiling goat milk transcriptome in colostrum and mature milk. BMC Vet Res. 2016;12:264 pubmed
    ..CSN2, PAEP, CSN1S2, CSN3, LALBA, TPT1, FTH1, M-SAA3, SPP1, GLYCAM1, EEF1A1, CTSD, FASN, RPS29, CSN1S1, KRT19 and CHEK1 were found between the top fifteen ..
  22. Kang B, Wang X, Xu Q, Wu Y, Si X, Jiang D. Effect of 3-nitropropionic acid inducing oxidative stress and apoptosis of granulosa cells in geese. Biosci Rep. 2018;38: pubmed publisher
    ..05). Moreover, the expression levels of NF-κB, Nrf2, Fhc, Hspa2 and Ho-1 in granulosa cells treated with 3-NPA were elevated 4.36-, 1.63-, 3.62-, 27.54- and 10...
  23. Feng T, Cao G, Chu M, DI R, Huang D, Liu Q, et al. Identification and verification of differentially expressed genes in the caprine hypothalamic-pituitary-gonadal axis that are associated with litter size. Mol Reprod Dev. 2015;82:132-8 pubmed publisher
    ..Three genes (FTH1, GH, and SAA) were selected to validate the SSH results by quantitative real-time PCR; all three were up-regulated ..
  24. Dabbous B, Brown D, Tsitlakidis A, Arzoglou V. Clinical outcomes during the learning curve of MIDline Lumbar Fusion (MIDLF®) using the cortical bone trajectory. Acta Neurochir (Wien). 2016;158:1413-20 pubmed publisher
    ..using CBT is safe and effective with comparable results to those published for posterior lumbar interbody fusion (PLIF) even with the learning curve of new procedures...
  25. Guo R, Li Q, Yang F, Hu X, Jiao J, Guo Y, et al. In Vivo MR Imaging of Dual MRI Reporter Genes and Deltex-1 Gene-modified Human Mesenchymal Stem Cells in the Treatment of Closed Penile Fracture. Mol Imaging Biol. 2018;20:417-427 pubmed publisher
    ..the feasibility of dual magnetic resonance imaging (MRI) reporter genes, including ferritin heavy subunit (Fth) and transferrin receptor (TfR), which provide sufficient MRI contrast for in vivo MRI tracking, and the Deltex-1 (..
  26. Hlaváčová M, Gumulec J, Stračina T, Fojtů M, Raudenská M, Masařík M, et al. Different doxorubicin formulations affect plasma 4-hydroxy-2-nonenal and gene expression of aldehyde dehydrogenase 3A1 and thioredoxin reductase 2 in rat. Physiol Res. 2015;64 Suppl 5:S653-60 pubmed
    ..Three forms of doxorubicin--conventional (DOX), encapsulated in liposomes (lipoDOX) and in apoferritin (apoDOX) were applied to Wistar rats...
  27. Qu H, Yin H, Yan S, Tao M, Xie Y, Chen W. Inhibitor of growth 4 suppresses colorectal cancer growth and invasion by inducing G1 arrest, inhibiting tumor angiogenesis and reversing epithelial-mesenchymal transition. Oncol Rep. 2016;35:2927-35 pubmed publisher
    ..CRC cells exhibited a lower level of ING4 compared to the level in normal human colorectal mucous epithelial FHC cells. Furthermore, ING4 expression in high metastatic CRC cells was less than that in low metastatic CRC cells...
  28. Bi B, Li F, Guo J, Li C, Jing R, Lv X, et al. Label-free quantitative proteomics unravels the importance of RNA processing in glioma malignancy. Neuroscience. 2017;351:84-95 pubmed publisher
    ..Upregulation of 40S ribosomal protein S5 (RPS5), Ferritin Heavy chain (FTH1) and STAT1, and downregulation of tenascin R (TNR) were validated as representatives by immune assays...
  29. Tanaka Y, Ikeda T, Yamamoto K, Masuda S, Ogawa H, Kamisako T. Gender-divergent expression of lipid and bile acid metabolism related genes in adult mice offspring of dams fed a high-fat diet. J Biosci. 2018;43:329-337 pubmed
    ..into eight groups in accordance with mother's and offspring's diets: male(M) CC, MHC, MCH, MHH, female(F) CC, FHC, FCH, and FHH. MHH showed greater weight gain compared to FHH. Liver weight was higher in MHH than in FHH...
  30. Mikkilä J, Anaya Plaza E, Liljeström V, Castón J, Torres T, Escosura A, et al. Hierarchical Organization of Organic Dyes and Protein Cages into Photoactive Crystals. ACS Nano. 2016;10:1565-71 pubmed publisher
    ..resulting tetracationic complex acts as a molecular glue that binds to the outer surface anionic patches of the apoferritin (aFt) protein cage, inducing cocrystallization...
  31. Costanzo F, Colombo M, Staempfli S, Santoro C, Marone M, Frank R, et al. Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res. 1986;14:721-36 pubmed
    ..Southern blot analysis on total human DNA reveals that there are many DNA segments hybridizing to the apoferritin H and L cDNA probes (1,2,4,6)...
  32. Boyd D, Jain S, Crampton J, Barrett K, Drysdale J. Isolation and characterization of a cDNA clone for human ferritin heavy chain. Proc Natl Acad Sci U S A. 1984;81:4751-5 pubmed
    ..Genomic analysis gives a complex pattern that suggests that ferritin H chains are encoded by a multigene family or have an unusually large number of exons. ..
  33. Bellinger J, Brandt H, Hardin J, Bynum S, Sharpe P, Jackson D. The role of family history of cancer on cervical cancer screening behavior in a population-based survey of women in the Southeastern United States. Womens Health Issues. 2013;23:e197-204 pubmed publisher
    Our objective was to determine the association of self-reported family history of cancer (FHC) on cervical cancer screening to inform a potential link with cancer preventive behaviors in a region with persistent cancer disparities...
  34. Su Q, Gu Y, Yu B, Yu F, He H, Zhang Q, et al. Association between Serum Ferritin Concentrations and Depressive Symptoms among Chinese Adults: A Population Study from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIHealth) Cohort Study. PLoS ONE. 2016;11:e0162682 pubmed publisher
    ..In conclusion, there is no significant relationship between serum ferritin concentrations and depressive symptoms among Chinese adults. ..
  35. Van Dyke A, Langhamer M, Zhu B, Pfeiffer R, Albanes D, Andreotti G, et al. Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project. Cancer Epidemiol Biomarkers Prev. 2018;27:348-351 pubmed publisher
    ..and ampulla of Vater), the few studies that have examined the relationships between family history of cancer (FHC) and BTCs have reported inconclusive findings...
  36. Roberts G, Perry J, Al Jefri A, Scott C. Intra-leukocytic hemosiderin inclusions detected as pseudoeosinophils by automated depolarization analysis in a patient with beta-thalassaemia major and immune hemolysis. Blood Cells Mol Dis. 2005;34:162-5 pubmed
    ..The implications for the hematology morphologist is that visual inspection of a blood smear is nearly always indicated whenever any departure from strict normality is noted in the output from an automated blood cell counter. ..
  37. Zou W, Liu X, Chen D, Wang J, Zhao X, Li J, et al. Expression, purification, and characterization of recombinant human H-chain ferritin. Prep Biochem Biotechnol. 2016;46:833-837 pubmed
    ..Moreover, the rHF nanocages were characterized by transmission electron microscopy and dynamic light scattering. Our results indicate that rHF is able to self-assemble into nanocages with a narrow size distribution. ..
  38. Song X, Xie Y, Kang R, Hou W, Sun X, Epperly M, et al. FANCD2 protects against bone marrow injury from ferroptosis. Biochem Biophys Res Commun. 2016;480:443-449 pubmed publisher
    ..Mechanically, FANCD2 regulated genes and/or expression of proteins involved in iron metabolism (e.g., FTH1, TF, TFRC, HAMP, HSPB1, SLC40A1, and STEAP3) and lipid peroxidation (e.g., GPX4)...
  39. Liu F, Du Z, He J, Liu X, Yu Q, Wang Y. FTH1 binds to Daxx and inhibits Daxx-mediated cell apoptosis. Mol Biol Rep. 2012;39:873-9 pubmed publisher
    ..One of the candidate proteins was identified as ferritin, heavy polypeptide 1(FTH1)...
  40. López Prieto J, Gonzalez Reimers E, Alemán Valls M, de la Vega Prieto M, Abreu Gonzalez P, Pelazas González R, et al. Iron and proinflammatory cytokines in chronic hepatitis C virus infection. Biol Trace Elem Res. 2013;155:5-10 pubmed publisher
    ..Serum ferritin is higher among those with intense steatosis and also shows a (non-significant) trend to be associated with the more severe forms of hepatitis...
  41. Hsu P, Jiang N, Patnaik A, Katta V, Roy S, Gord J. All Fiber-Coupled OH Planar Laser-Induced-Fluorescence (OH-PLIF)-Based Two-Dimensional Thermometry. Appl Spectrosc. 2017;:3702817744519 pubmed publisher
    Two-color, planar laser-induced fluorescence (PLIF)-based two-dimensional (2D) thermometry techniques for reacting flows, which are typically developed in the laboratory conditions, face a stiff challenge in their practical implementation ..
  42. Dorner M, Salfeld J, Will H, Leibold E, Vass J, Munro H. Structure of human ferritin light subunit messenger RNA: comparison with heavy subunit message and functional implications. Proc Natl Acad Sci U S A. 1985;82:3139-43 pubmed
    ..This suggests that L and H subunits are structurally interchangeable in forming an apoferritin shell...
  43. Li L, Fang C, Ryan J, Niemi E, Lebron J, Bjorkman P, et al. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010;107:3505-10 pubmed publisher
    Ferritin is a spherical molecule composed of 24 subunits of two types, ferritin H chain (FHC) and ferritin L chain (FLC)...
  44. Yang Y, Gong M, Yang H, Zhang S, Wang G, Su T, et al. MR molecular imaging of tumours using ferritin heavy chain reporter gene expression mediated by the hTERT promoter. Eur Radiol. 2016;26:4089-4097 pubmed
    Using the human telomerase reverse transcriptase (hTERT) promoter and the modified ferritin heavy chain (Fth) reporter gene, reporter gene expression for MRI was examined in telomerase positive and negative tumour cells and xenografts...
  45. de Kunder S, van Kuijk S, Rijkers K, Caelers I, van Hemert W, de Bie R, et al. Transforaminal lumbar interbody fusion (TLIF) versus posterior lumbar interbody fusion (PLIF) in lumbar spondylolisthesis: a systematic review and meta-analysis. Spine J. 2017;17:1712-1721 pubmed publisher
    Transforaminal lumbar interbody fusion (TLIF) and posterior lumbar interbody fusion (PLIF) are both frequently used as a surgical treatment for lumbar spondylolisthesis...
  46. Dündar C. Health-seeking behavior and medical facility choice in Samsun, Turkey. Health Policy. 2017;121:1015-1019 pubmed publisher
    ..This descriptive study was conducted in five family health centers (FHC) and in six hospitals in Samsun Province in Turkey...
  47. Laghaei R, Evans D, Coalson R. Metal binding sites of human H-chain ferritin and iron transport mechanism to the ferroxidase sites: a molecular dynamics simulation study. Proteins. 2013;81:1042-50 pubmed publisher
    ..The Fe(2+) ion binds preferentially to site A of the ferroxidase site. ..
  48. Yang E, Xu J, Liu X, Jin G, Xiao W, Zeng B, et al. An RCT study comparing the clinical and radiological outcomes with the use of PLIF or TLIF after instrumented reduction in adult isthmic spondylolisthesis. Eur Spine J. 2016;25:1587-1594 pubmed publisher
    We prospectively compared posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) used in adult isthmic spondylolisthesis (IS) after surgical reduction with pedicle screws...
  49. Linzer P, Filip M, Jurek P, Šálek T, Gajdoš M, Jarkovský J. Comparison of biochemical response between the minimally invasive and standard open posterior lumbar interbody fusion. Neurol Neurochir Pol. 2016;50:16-23 pubmed publisher
    The mini-invasive open posterior lumbar fusion procedure (mini PLIF) procedure is an alternative to standard open procedure (open PLIF) and is intended to reduce surgery-related trauma...
  50. Chen X, Liu X, He B, Pan Y, Sun H, Xu T, et al. MiR-216b functions as a tumor suppressor by targeting HMGB1-mediated JAK2/STAT3 signaling way in colorectal cancer. Am J Cancer Res. 2017;7:2051-2069 pubmed
    ..decreased compared with corresponding adjacent normal tissues (ANTs) and colonic mucosal epithelial cell line (FHC), and was obviously associated with the TNM stage, lymph node metastases, differentiation and poor overall survival ..
  51. Lawson D, Artymiuk P, Yewdall S, Smith J, Livingstone J, Treffry A, et al. Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts. Nature. 1991;349:541-4 pubmed
    ..The X-ray structure of human H ferritin shows a novel metal site embedded within each of its four-helix bundles and we suggest that ferroxidase activity associated with this site accounts for its rapid uptake of iron. ..
  52. Segura Trepichio M, Candela Zaplana D, Montoza Nuñez J, Martin Benlloch A, Nolasco A. Length of stay, costs, and complications in lumbar disc herniation surgery by standard PLIF versus a new dynamic interspinous stabilization technique. Patient Saf Surg. 2017;11:26 pubmed publisher
    ..Therefore, there is a greater concern about the costs and safety of the techniques and implants used...
  53. Abdullah H, Zhang Z, Yee K, Haroon N. KIR3DL1 interaction with HLA-B27 is altered by ankylosing spondylitis associated ERAP1 and enhanced by MHC class I cross-linking. Discov Med. 2015;20:79-89 pubmed
    ..Dysfunction of ERAP1 is hypothesized to cause changes in expression of HLA-B27 classical (pHLA) and non-classical (FHC) conformers on antigen presenting cells (APCs), which interact with the natural killer (NK) cell receptor KIR3DL1...
  54. Choi S, Kim S, Cho H, Jang J, Lin Y, Tuller H, et al. WO3 Nanofiber-Based Biomarker Detectors Enabled by Protein-Encapsulated Catalyst Self-Assembled on Polystyrene Colloid Templates. Small. 2016;12:911-20 pubmed publisher
    ..The metallic NPs, composed of Au, Pd, or Pt, are encapsulated within a protein cage, i.e., apoferritin, to form unagglomerated monodispersed particles with diameters of less than 5 nm...
  55. Maruenda J, Barrios C, Garibo F, Maruenda B. Adjacent segment degeneration and revision surgery after circumferential lumbar fusion: outcomes throughout 15 years of follow-up. Eur Spine J. 2016;25:1550-1557 pubmed publisher
    ..outcomes (15 years) of circumferential lumbar fusion (CF) for degenerative spine disease using instrumented PLIF. The occurrence of adjacent segment degeneration (ASD) and the reintervention rate was specially focused...
  56. Jurado R, Castello F, Bondia P, Casado S, Flors C, Cuesta R, et al. Apoferritin fibers: a new template for 1D fluorescent hybrid nanostructures. Nanoscale. 2016;8:9648-56 pubmed publisher
    ..The formation of apoferritin amyloid-like protein fibers is demonstrated herein for the first time...
  57. Wu H, Pang Q, Jiang G. Medium-term effects of Dynesys dynamic stabilization versus posterior lumbar interbody fusion for treatment of multisegmental lumbar degenerative disease. J Int Med Res. 2017;45:1562-1573 pubmed publisher
    ..clinical and radiographic outcomes of Dynesys dynamic stabilization and posterior lumbar interbody fusion (PLIF) for treatment of multisegmental lumbar degenerative disease...
  58. Yun D, Yu J, Jeon S, Lee H, Lee S. Salvage Anterior Lumbar Interbody Fusion for Pseudoarthrosis After Posterior or Transforaminal Lumbar Interbody Fusion: A Review of 10 Patients. World Neurosurg. 2018;111:e746-e755 pubmed publisher
    After interbody cage implantation for posterior or transforaminal lumbar interbody fusion (PLIF or TLIF) spinal fusion surgery, pseudoarthrosis can develop...
  59. Kuruppu A, Zhang L, Collins H, Turyanska L, Thomas N, Bradshaw T. An Apoferritin-based Drug Delivery System for the Tyrosine Kinase Inhibitor Gefitinib. Adv Healthc Mater. 2015;4:2816-21 pubmed publisher
    Anticancer drug Gefitinib encapsulated within human heavy chain apoferritin by diffusion allows pH-controlled sustained release of cargo...
  60. Han C, Wang R, Wang K, Xu H, Sui M, Li J, et al. Highly fluorescent carbon dots as selective and sensitive "on-off-on" probes for iron(III) ion and apoferritin detection and imaging in living cells. Biosens Bioelectron. 2016;83:229-36 pubmed publisher
    ..The quenched fluorescence could be turned on after the addition of apoferritin owing to the removal of ferric species from the surface of N-CDs by apoferritin, making complex N-CDs/Fe(3+) a ..
  61. Zhou J, Yao H, Meng L, Sun C, Ye W, Du Q. A Hollow NaGdF4 /AFn Nanosystem Based on "Relay Race" Release for Therapy. ChemMedChem. 2017;12:1191-1200 pubmed publisher
    ..curcumin (CUR) was physically entrapped into hollow upconversion NaGdF4 nanomaterial, then apoferritin (AFn) loaded with doxorubicin (DOX) was attached to the NaGdF4 surface...
  62. Derman P, Albert T. Interbody Fusion Techniques in the Surgical Management of Degenerative Lumbar Spondylolisthesis. Curr Rev Musculoskelet Med. 2017;10:530-538 pubmed publisher
    ..Anterior (ALIF), lateral (LLIF), posterior (PLIF), transforaminal (TLIF), and axial (AxiaLIF) lumbar IBF approaches have been described...
  63. Park S, An H, Lee S, Suh S, Kim J, Yoon S. A prospective randomized comparative study of postoperative pain control using an epidural catheter in patients undergoing posterior lumbar interbody fusion. Eur Spine J. 2016;25:1601-1607 pubmed publisher
    ..The epidural catheter tip was placed one level cephalad to the level of the PLIF in patients in the ED group...
  64. Eilert E, Hollenberg C, Piontek M, Suckow M. The use of highly expressed FTH1 as carrier protein for cytosolic targeting in Hansenula polymorpha. J Biotechnol. 2012;159:172-6 pubmed publisher
    ..To study whether the human ferritin heavy chain (FTH1) can be expressed in Hansenula polymorpha, we integrated an expression cassette for FTH1 and analyzed ..
  65. Jahshan A, Esteves Villanueva J, Martic Milne S. Evaluation of ferritin and transferrin binding to tau protein. J Inorg Biochem. 2016;162:127-134 pubmed publisher
    ..The interaction of apotransferrin or apoferritin with tau films was also evaluated...
  66. Faniello M, Chirico G, Quaresima B, Cuda G, Allevato G, Bevilacqua M, et al. An alternative model of H ferritin promoter transactivation by c-Jun. Biochem J. 2002;363:53-8 pubmed
    ..These results add a new level of complexity to transcriptional regulation by c-Jun, which can activate p300-dependent promoters without binding directly to the target DNA. ..
  67. Sakaura H, Miwa T, Yamashita T, Kuroda Y, Ohwada T. Cortical bone trajectory screw fixation versus traditional pedicle screw fixation for 2-level posterior lumbar interbody fusion: comparison of surgical outcomes for 2-level degenerative lumbar spondylolisthesis. J Neurosurg Spine. 2018;28:57-62 pubmed publisher
    ..fixation remains unclear, and surgical outcomes in patients after 2-level posterior lumbar interbody fusion (PLIF) using CBT screw fixation have not been reported...
  68. Mamoori A, Wahab R, Islam F, Lee K, Vider J, Lu C, et al. Clinical and biological significance of miR-193a-3p targeted KRAS in colorectal cancer pathogenesis. Hum Pathol. 2018;71:145-156 pubmed publisher
    ..Two colorectal cancer cell lines (SW480 and SW48) and a non-neoplastic colon cell line (FHC) were also used...
  69. Kato J, Fujikawa K, Kanda M, Fukuda N, Sasaki K, Takayama T, et al. A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Am J Hum Genet. 2001;69:191-7 pubmed
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    Familial hypertrophic cardiomyopathy (FHC) is associated with mild to severe cardiac problems and is the leading cause of sudden death in young people and athletes...
  71. Jurado R, Frączek P, Droetto M, Sánchez P, Valero E, Domínguez Vera J, et al. Apomaghemite as a doxorubicin carrier for anticancer drug delivery. J Inorg Biochem. 2016;157:46-51 pubmed publisher
    ..Taking advantage of the unique structure feature of apoferritin, a new theranostic nanocarrier is proposed herein...
  72. Rafiq R, Bhat G, Lone M, Masood A, Dar N. Potential risk of esophageal squamous cell carcinoma due to nucleotide excision repair XPA and XPC gene variants and their interaction among themselves and with environmental factors. Tumour Biol. 2016;37:10193-207 pubmed publisher
    ..42; 95 % CI = 3.30-16.69), or had a positive family history of cancer (FHC) (OR = 9.47; 95 % CI = 4.67-19.20)...
  73. Tsai P, Hsu C, Chen S, Wu T, Huang C. Biomechanical investigation into the structural design of porous additive manufactured cages using numerical and experimental approaches. Comput Biol Med. 2016;76:14-23 pubmed publisher
    Traditional solid cages have been widely used in posterior lumbar interbody fusion (PLIF) surgery. However, solid cages significantly affect the loading mechanism of the human spine due to their extremely high structural stiffness...
  74. Di Sanzo M, Gaspari M, Misaggi R, Romeo F, Falbo L, De Marco C, et al. H ferritin gene silencing in a human metastatic melanoma cell line: a proteomic analysis. J Proteome Res. 2011;10:5444-53 pubmed publisher
    ..Besides regulating intracellular iron homeostasis, it has been found that ferritin, in particular the H subunit (FHC), is involved in different biological events such as cell differentiation and pathologic states (i.e...
  75. Ren C, Li Y, Chen Q, Zeng Y, Shao Y, Wu Q, et al. Oridonin inhibits the proliferation of human colon cancer cells by upregulating BMP7 to activate p38 MAPK. Oncol Rep. 2016;35:2691-8 pubmed publisher
    ..results indicated that BMP7 was greatly upregulated by ORI in the HCT116 cells, but its endogenous expression in FHC cells was apparently lower than that in the colon cancer cell lines...
  76. Boymans T, Veldman H, Grimm B, Noble P, Heyligers I. Femoral Head Size is Correlated With Head Position in Very Elderly Patients. J Arthroplasty. 2017;32:587-593 pubmed publisher
    ..between the femoral head diameter (FHD) and the distance between the lesser trochanter and the femoral head center (LT-FHC) in the very elderly (aged ?80 years) as the mainly affected but yet underinvestigated group.
  77. Wahab R, Gopalan V, Islam F, Smith R, Qiao B, Lam A. Cellular expression, in-vitro and in-vivo confirmation of GAEC1 oncogenic properties in colon cancer. Eur J Cell Biol. 2017;96:487-495 pubmed publisher
    ..cancer cells (SW480-Stage II, SW48-Stage III and HCT116-Stage IV) when compared to non-neoplastic colon cells (FHC cells) by immunocytochemistry, immunofluorescence, western blot analysis and real-time polymerase chain reaction...
  78. Kasztura M, Dzięgała M, Kobak K, Bania J, Mazur G, Banasiak W, et al. Both iron excess and iron depletion impair viability of rat H9C2 cardiomyocytes and L6G8C5 myocytes. Kardiol Pol. 2017;75:267-275 pubmed publisher
    ..We analysed the mRNA expression of: ferritin heavy and light chains (FTH and FTL; iron storage proteins), myoglobin (MB, oxygen storage protein) ferroportin type 1 (FPN1; iron exporter), ..
  79. Sammarco M, Ditch S, Banerjee A, Grabczyk E. Ferritin L and H subunits are differentially regulated on a post-transcriptional level. J Biol Chem. 2008;283:4578-87 pubmed
    ..Ferritin in animals is composed of 24 ferritin L (FTL) and ferritin H (FTH) subunits in ratios that vary in different cell types...
  80. Moroz C, Traub L, Rabizadeh E, Zahalka M. A proof of concept study: human C48-placenta immunoregulatory factor is an effective, single therapeutic agent enabling allogeneic, nonmanipulated murine bone marrow transplantation. Exp Hematol. 2009;37:1121-30 pubmed publisher
    Cloned placenta immunoregulatory ferritin (PLIF) contains a novel, nonferritin bioactive domain (C-48) with immunodulatory activity...
  81. de Kunder S, Rijkers K, van Kuijk S, Evers S, de Bie R, van Santbrink H. A protocol of a randomized controlled multicenter trial for surgical treatment of lumbar spondylolisthesis: the Lumbar Interbody Fusion Trial (LIFT). BMC Musculoskelet Disord. 2016;17:417 pubmed
    ..for lumbar spondylolisthesis, transforaminal lumbar interbody fusion (TLIF) and posterior lumbar interbody fusion (PLIF), are not sufficient...
  82. Rosager A, Sørensen M, Dahlrot R, Hansen S, Schonberg D, Rich J, et al. Transferrin receptor-1 and ferritin heavy and light chains in astrocytic brain tumors: Expression and prognostic value. PLoS ONE. 2017;12:e0182954 pubmed publisher
    ..was to investigate the expression and prognostic value of transferrin receptor-1 (TfR1) as well as ferritin heavy (FTH) and light (FTL) chain in astrocytic brain tumors...
  83. Rozan L, El Deiry W. Identification and characterization of proteins interacting with Traf4, an enigmatic p53 target. Cancer Biol Ther. 2006;5:1228-35 pubmed
  84. Kim S, Kim U, Jang M, Kang S, Jang H, Jung S, et al. Diagnostic use of serum ferritin levels to differentiate infectious and noninfectious diseases in patients with fever of unknown origin. Dis Markers. 2013;34:211-8 pubmed publisher
    ..04). An optimal cutoff value of serum ferritin levels to predict FUO caused by a noninfectious disease (hematologic diseases, noninfectious inflammatory diseases) was established as 561 ng/mL. ..
  85. Zhang X, Su A, Hu M, Zhang X, Xu Y. Elevated serum ferritin levels in patients with hematologic malignancies. Asian Pac J Cancer Prev. 2014;15:6099-101 pubmed
  86. Javaheri Kermani M, Farazmandfar T, Ajami A, Yazdani Y. Impact of hepcidin antimicrobial peptide on iron overload in tuberculosis patients. Scand J Infect Dis. 2014;46:693-6 pubmed publisher
    ..These observations indicate a hypothetical role of this polymorphism in iron metabolism. Hepcidin could perhaps be an option for the treatment of TB. ..
  87. Gryzik M, Srivastava A, Longhi G, Bertuzzi M, Gianoncelli A, Carmona F, et al. Expression and characterization of the ferritin binding domain of Nuclear Receptor Coactivator-4 (NCOA4). Biochim Biophys Acta Gen Subj. 2017;1861:2710-2716 pubmed publisher
    ..The iron-dependent, highly-specific formation of the remarkably stable H-ferritin-NCOA4 complex shown in this work may be important for the characterization of the mechanism of ferritinophagy. ..
  88. Chiou Y, Chen Y, Ke T, Ko W. The effect of increased oxidative stress and ferritin in reducing the effectiveness of therapy in chronic hepatitis C patients. Clin Biochem. 2012;45:1389-93 pubmed publisher
    ..01). This study indicated that decreased ferritin, decreased TBARS and increased TAS status may improve the efficacy of treatment. ..
  89. Arosio P, Carmona F, Gozzelino R, Maccarinelli F, Poli M. The importance of eukaryotic ferritins in iron handling and cytoprotection. Biochem J. 2015;472:1-15 pubmed publisher
    ..Less clear are the properties of the secretory ferritins expressed by insects and molluscs, which may be important for understanding the role played by serum ferritin in mammals. ..
  90. Eid R, Boucher E, Gharib N, Khoury C, Arab N, Murray A, et al. Identification of human ferritin, heavy polypeptide 1 (FTH1) and yeast RGI1 (YER067W) as pro-survival sequences that counteract the effects of Bax and copper in Saccharomyces cerevisiae. Exp Cell Res. 2016;342:52-61 pubmed publisher
    ..Here we describe the identification and characterization of human ferritin, heavy polypeptide 1 (FTH1) as a suppressor of the pro-apoptotic murine Bax sequence in yeast...
  91. Mehlenbacher M, Poli M, Arosio P, Santambrogio P, Levi S, Chasteen N, et al. Iron Oxidation and Core Formation in Recombinant Heteropolymeric Human Ferritins. Biochemistry. 2017;56:3900-3912 pubmed publisher
    ..The L-rich ferritin, while also facilitating iron oxidation at the FC, additionally promoted oxidation at the mineral surface once the iron binding capacity of the FC was exceeded. ..
  92. Kaushik N, Malaspina A, de Belleroche J. Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization. DNA Cell Biol. 2000;19:265-73 pubmed
    ..Characterization of polymorphic TNRs in novel and even known genes expressed in human spinal cord is likely to help in the identification of new candidates for genes involved in neurodegenerative disorders. ..