FRS2

Summary

Gene Symbol: FRS2
Description: fibroblast growth factor receptor substrate 2
Alias: FRS1A, FRS2A, FRS2alpha, SNT, SNT-1, SNT1, fibroblast growth factor receptor substrate 2, FGFR signalling adaptor, FGFR substrate 2, FGFR-signaling adaptor SNT, suc1-associated neurotrophic factor target 1
Species: human
Products:     FRS2

Top Publications

  1. Kouhara H, Hadari Y, Spivak Kroizman T, Schilling J, Bar Sagi D, Lax I, et al. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell. 1997;89:693-702 pubmed
    ..In this report, we describe the purification, cloning, and characterization of a novel protein, designated FRS2, that is tyrosine phosphorylated and binds to Grb2/Sos in response to FGF or NGF stimulation...
  2. Kurokawa K, Iwashita T, Murakami H, Hayashi H, Kawai K, Takahashi M. Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. Oncogene. 2001;20:1929-38 pubmed
    SNT/FRS2 is a lipid anchored docking protein that contains an amino-terminal myristylation signal, followed by a phosphotyrosine-binding (PTB) domain and a carboxy-terminal region with multiple tyrosine residues...
  3. Melillo R, Santoro M, Ong S, Billaud M, Fusco A, Hadari Y, et al. Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol. 2001;21:4177-87 pubmed
    ..In this report we demonstrate that the docking protein FRS2 is tyrosine phosphorylated by ligand-stimulated and by constitutively activated oncogenic forms of RET...
  4. Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A. FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci U S A. 2002;99:6684-9 pubmed
    ..Here, we demonstrate that Grb2 bound to tyrosine-phosphorylated FRS2 alpha forms a ternary complex with Cbl by means of its Src homology 3 domains resulting in the ubiquitination of ..
  5. Hadari Y, Kouhara H, Lax I, Schlessinger J. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation. Mol Cell Biol. 1998;18:3966-73 pubmed
    b>FRS2 is a lipid-anchored docking protein that plays an important role in linking fibroblast growth factor (FGF) and nerve growth factor receptors with the Ras/mitogen-activated protein (MAP) kinase signaling pathway...
  6. Meakin S, MacDonald J, Gryz E, Kubu C, Verdi J. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem. 1999;274:9861-70 pubmed
    ..Importantly, overexpression of FRS-2 in cells expressing an NGF nonresponsive TrkA receptor mutant reconstitutes the ability of NGF to stop cell cycle progression and to stimulate neuronal differentiation. ..
  7. Hadari Y, Gotoh N, Kouhara H, Lax I, Schlessinger J. Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci U S A. 2001;98:8578-83 pubmed
    The docking protein FRS2 alpha has been implicated as a mediator of signaling via fibroblast growth factor receptors (FGFRs)...
  8. Ridyard M, Robbins S. Fibroblast growth factor-2-induced signaling through lipid raft-associated fibroblast growth factor receptor substrate 2 (FRS2). J Biol Chem. 2003;278:13803-9 pubmed
    ..Herein, we show that this protein is the signaling adaptor FRS2 and that it is localized exclusively to lipid rafts in vitro and in vivo...
  9. Xu H, Lee K, Goldfarb M. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins. J Biol Chem. 1998;273:17987-90 pubmed
    Fibroblast growth factors (FGFs) stimulate tyrosine phosphorylation of a membrane-anchored adapter protein, FRS2/SNT-1, promoting its association with Shp-2 tyrosine phosphatase and upstream activators of Ras...

More Information

Publications110 found, 100 shown here

  1. Delahaye L, Rocchi S, Van Obberghen E. Potential involvement of FRS2 in insulin signaling. Endocrinology. 2000;141:621-8 pubmed
    ..Using this approach, we isolated FRS2 as a potential target for tyrosine phosphorylation by the IR...
  2. Ong S, Hadari Y, Gotoh N, Guy G, Schlessinger J, Lax I. Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins. Proc Natl Acad Sci U S A. 2001;98:6074-9 pubmed
    ..We demonstrate that tyrosine phosphorylation of FRS2alpha leads to Grb2-mediated complex formation with the docking protein Gab1 and its tyrosine phosphorylation, ..
  3. Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, et al. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol Cell. 2002;10:709-19 pubmed
    The docking protein FRS2alpha functions as a major mediator of signaling by FGF and NGF receptors...
  4. Wu Y, Chen Z, Ullrich A. EGFR and FGFR signaling through FRS2 is subject to negative feedback control by ERK1/2. Biol Chem. 2003;384:1215-26 pubmed
    Fibroblast growth factor (FGF) receptor substrate 2 (FRS2) is a membrane-anchored docking protein that has been shown to play an important role in linking FGF, nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF) ..
  5. Ong S, Guy G, Hadari Y, Laks S, Gotoh N, Schlessinger J, et al. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol. 2000;20:979-89 pubmed
    ..The two members of the FRS2 family, FRS2alpha and FRS2beta, are structurally very similar...
  6. Böhm B, Schade B, Bauer B, Hoffmann B, Hoffmann D, Ziegler U, et al. Tick-borne encephalitis in a naturally infected sheep. BMC Vet Res. 2017;13:267 pubmed publisher
    ..the herd was positive for TBEV in an enzyme-linked immunosorbent assay (ELISA) and in a serum neutralisation test (SNT), and one was borderline in an ELISA...
  7. Thompson L, Penner C, Ho N, Foss R, Miettinen M, Wieneke J, et al. Sinonasal tract and nasopharyngeal adenoid cystic carcinoma: a clinicopathologic and immunophenotypic study of 86 cases. Head Neck Pathol. 2014;8:88-109 pubmed publisher
    ..4 years), and 35 patients were either alive or had died of unrelated causes (mean 16.3 years). ACC of the SNT is uncommon. Recurrences are common...
  8. La Ferla M, Mercatanti A, Rocchi G, Lodovichi S, Cervelli T, Pignata L, et al. Expression of human poly (ADP-ribose) polymerase 1 in Saccharomyces cerevisiae: Effect on survival, homologous recombination and identification of genes involved in intracellular localization. Mutat Res. 2015;774:14-24 pubmed publisher
    ..histone H1 gene HHO1, the HUL4 gene, the deubiquitination enzyme gene OTU1, the nuclear pore protein POM152 and the SNT1 that encodes for the Set3C subunit of the histone deacetylase complex...
  9. Venkatesan G, Kumar Teli M, Sankar M, Kumar A, Dashprakash M, Arya S, et al. Expression and evaluation of recombinant P32 protein based ELISA for sero-diagnostic potential of capripox in sheep and goats. Mol Cell Probes. 2018;37:48-54 pubmed publisher
    ..7% and sensitivity of 97.1/98.1% when compared to whole virus antigen based ELISA/SNT by receiver operating characteristic (ROC) analysis...
  10. Tran T, Leong H, Pavía Jiménez A, Fedyshyn S, Yang J, Kucejova B, et al. Fibroblast Growth Factor Receptor-Dependent and -Independent Paracrine Signaling by Sunitinib-Resistant Renal Cell Carcinoma. Mol Cell Biol. 2016;36:1836-55 pubmed publisher
    ..As determined by fibroblast growth factor receptor substrate 2 (FRS2) phosphorylation in fibroblasts, RCC broadly induced low-level fibroblast growth factor ..
  11. Tohyama O, Matsui J, Kodama K, Hata Sugi N, Kimura T, Okamoto K, et al. Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models. J Thyroid Res. 2014;2014:638747 pubmed publisher
    ..cells overexpressed FGFR1 and that lenvatinib inhibited the phosphorylation of FGFR1 and its downstream effector FRS2. Lenvatinib also inhibited the phosphorylation of RET with the activated mutation C634W in TT cells...
  12. Manchado E, Weissmueller S, Morris J, Chen C, Wullenkord R, Lujambio A, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016;534:647-51 pubmed
    ..Importantly, KRAS-mutant lung cancer cells and patients’ tumours treated with trametinib show an increase in FRS2 phosphorylation, a biomarker of FGFR activation; this increase is abolished by FGFR1 inhibition and correlates with ..
  13. Kumar A, Yogisharadhya R, Venkatesan G, Bhanuprakash V, Pandey A, Shivachandra S. Co-administration of recombinant major envelope proteins (rA27L and rH3L) of buffalopox virus provides enhanced immunogenicity and protective efficacy in animal models. Antiviral Res. 2017;141:174-178 pubmed publisher
    ..serum IgG as well as neutralizing antibody titers measured by using indirect-ELISA and serum neutralization test (SNT) respectively, which were higher as compared to that elicited by individual antigens...
  14. Narayana J, Horton W. FGFR3 biology and skeletal disease. Connect Tissue Res. 2015;56:427-33 pubmed publisher
    ..in the receptor's kinase domain and in the tightly linked scaffold protein Fibroblast Receptor Factor Substrate 2 (FRS2)...
  15. Caverzasio J, Thouverey C. Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth. Cell Physiol Biochem. 2011;27:243-50 pubmed publisher
    ..Associated with this observation, SrRan induced rapid activation of FGFR signaling pathways such as PLCγ, FRS2, Akt, ERK1,2 and p38...
  16. Olarinmoye A, Olugasa B, Niphuis H, Herwijnen R, Verschoor E, Boug A, et al. Serological evidence of coronavirus infections in native hamadryas baboons (Papio hamadryas hamadryas) of the Kingdom of Saudi Arabia. Epidemiol Infect. 2017;145:2030-2037 pubmed publisher
    ..Enzyme-linked Immunosorbent Assay (ELISA) technique and for MERSCoV antibodies using Serum Neutralization Test (SNT)...
  17. Luo T, Yi X, Si W. Identification of miRNA and genes involving in osteosarcoma by comprehensive analysis of microRNA and copy number variation data. Oncol Lett. 2017;14:5427-5433 pubmed publisher
    ..hsa-miR-27a-3p, hsa-miR-124-3p, hsa-miR-9-5p, hsa-miR-182-5p, hsa-miR-26a-5p) and the genes [Fibroblast growth factor receptor substrate 2 (FRS2), coronin 1C (CORO1C), forkhead box P1 (FOXP1), cytoplasmic ..
  18. Kostas M, Haugsten E, Zhen Y, Sørensen V, Szybowska P, Fiorito E, et al. Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. Mol Cell Proteomics. 2018;17:850-870 pubmed publisher
    ..Many known FGFR interactors were identified (e.g. FRS2, PLCG1, RSK2, SRC), but the data also suggested novel determinants...
  19. Ke K, Li H, Yao H, Shi X, Dong C, Zhu Y, et al. In silico prediction and in vitro and in vivo validation of acaricide fluazuron as a potential inhibitor of FGFR3 and a candidate anticancer drug for bladder carcinoma. Chem Biol Drug Des. 2017;89:505-513 pubmed publisher
    ..the percentage of apoptosis cells, and decreased the phosphorylation level of FGFR3 and its downstream proteins FRS2-?, AKT, and ERK...
  20. Zhang G, Scarborough H, Kim J, Rozhok A, Chen Y, Zhang X, et al. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors. Sci Signal. 2016;9:rs12 pubmed
    ..Among these, knocking down fibroblast growth factor receptor substrate 2 (FRS2) or coiled-coil and C2 domain-containing protein 1A (CC2D1A), both scaffolding proteins, ..
  21. Li C, MacDonald J, Talebian A, Leuenberger J, Seah C, Pasternak S, et al. Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells. Mol Cell Biol. 2016;36:2596-611 pubmed publisher
    ..inhibition of RhoB via phosphorylation at Ser(185) by casein kinase 1, which relieves actin stress fibers, and (ii) FRS2-scaffolded Src and H-Ras activation of RhoA, which stimulate actin reorganization and the formation of lamellipodia...
  22. Fafilek B, Balek L, Bosakova M, Varecha M, Nita A, Gregor T, et al. The inositol phosphatase SHIP2 enables sustained ERK activation downstream of FGF receptors by recruiting Src kinases. Sci Signal. 2018;11: pubmed publisher
    ..was phosphorylated by active FGFRs, and promoted FGFR-ERK signaling at the level of phosphorylation of the adaptor FRS2 and recruitment of the tyrosine phosphatase PTPN11...
  23. Kumar A, Yogisharadhya R, Bhanuprakash V, Venkatesan G, Shivachandra S. Structural analysis and immunogenicity of recombinant major envelope protein (rA27L) of buffalopox virus, a zoonotic Indian vaccinia-like virus. Vaccine. 2015;33:5396-5405 pubmed publisher
    ..Immune response measured by using indirect-ELISA and SNT revealed a gradual increase in antigen specific serum IgG as well as neutralization antibody titers...
  24. Bennett J, Tan T, Alcantara D, Tétrault M, Timms A, Jensen D, et al. Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis. Am J Hum Genet. 2016;98:579-587 pubmed publisher
    ..Functional studies of ECCL fibroblast cell lines show increased levels of phosphorylated FGFRs and phosphorylated FRS2, a direct substrate of FGFR1, as well as constitutive activation of RAS-MAPK signaling...
  25. Tanizaki J, Ercan D, Capelletti M, Dodge M, Xu C, Bahcall M, et al. Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2. Cancer Res. 2015;75:3139-46 pubmed publisher
    ..but nevertheless can activate downstream signaling pathways through their interactions with fibroblast growth factor receptor substrate 2 (FRS2)...
  26. Ackermann Gäumann R, Tritten M, Hassan M, Lienhard R. Comparison of three commercial IgG and IgM ELISA kits for the detection of tick-borne encephalitis virus antibodies. Ticks Tick Borne Dis. 2018;9:956-962 pubmed publisher
    ..Reference values defined by serum neutralization test (SNT, n = 25) or results provided by EQA organizers (n = 2) were established for a subset of samples...
  27. Leto L, Testa M, Feola M. The predictive value of plasma biomarkers in discharged heart failure patients: role of plasma NT-proBNP. Minerva Cardioangiol. 2016;64:157-64 pubmed
    ..A 30% variation in NT-proBNP levels during in-hospital stay seemed to be an optimal cut-off for prognostic role. SNT-proBNP plasma levels proved to have a strong correlation with all-cause mortality, cardiovascular mortality, ..
  28. Abo El Sooud K, Hashem M, Abd Elhakim Y, Kamel G, Gab Allaha A. Effect of butylated hydroxyl toluene on the immune response of Rift Valley fever vaccine in a murine model. Int Immunopharmacol. 2018;62:165-169 pubmed publisher
    ..with IgG antibodies titer using enzyme-linked immune-sorbent assay (ELISA) test, serum neutralization test (SNT) and challenge test...
  29. De A, Das T, Chand K, Debnath B, Dey S, Hemadri D, et al. Seroprevalence of bluetongue and presence of viral antigen and type-specific neutralizing antibodies in goats in Tripura, a state at Indo-Bangladesh border of northeastern India. Trop Anim Health Prod. 2019;51:261-265 pubmed publisher
    ..of neutralizing antibodies in selected serum samples (n = 72) was investigated by serum neutralization test (SNT) against six bluetongue virus (BTV) serotypes and BTV-1 was found as most predominant (65...
  30. Yang Y, Adeola A, Xie H, Zhang Y. Genomic and transcriptomic analyses reveal selection of genes for puberty in Bama Xiang pigs. Zool Res. 2018;39:424-430 pubmed publisher
    ..The CTTNBP2NL, FRS2, KANK4, and KATNAL1 genes were under selection and exhibited expressional changes in the ..
  31. Rouby S, Aboulsoud E. Evidence of intrauterine transmission of lumpy skin disease virus. Vet J. 2016;209:193-5 pubmed publisher
    ..Results of ELISA and serum neutralization test (SNT) confirmed that the calf had developed precolostral serum antibodies to LSD virus indicating in utero virus ..
  32. Dabrowski A, Terauchi A, Strong C, Umemori H. Distinct sets of FGF receptors sculpt excitatory and inhibitory synaptogenesis. Development. 2015;142:1818-30 pubmed publisher
    ..We further find that FGFRs are required in the presynaptic neuron to respond to FGF22, and that FRS2 and PI3K, but not PLC?, mediate FGF22-dependent presynaptic differentiation...
  33. Li X, Hou Z, Zhang Y, Zhang G, Lian J, Lin J. New insight into modulated up-conversion luminescent silica nanotubes as efficient adsorbents for colored effluents. Dalton Trans. 2014;43:15457-64 pubmed publisher
    ..More importantly, the UC-SNT adsorbents are piece-like and could be effectively and quickly separated via filtration or centrifugation...
  34. Cha J, Maddileti S, Mitin N, Harden T, Der C. Aberrant receptor internalization and enhanced FRS2-dependent signaling contribute to the transforming activity of the fibroblast growth factor receptor 2 IIIb C3 isoform. J Biol Chem. 2009;284:6227-40 pubmed publisher
    ..We also determined that loss of Tyr-770 caused persistent activation of FRS2 by enhancing FRS2 binding to FGFR2 IIIb...
  35. Khoshim K, Hersant B, Hotz C, SidAhmed Mezi M, Meningaud J. Wound healing of cutaneous substance losses based on infectious, inflammatory and traumatic skin disorders: The experience of a center. Ann Chir Plast Esthet. 2018;63:330-337 pubmed publisher
    ..surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data ..
  36. Stoletov K, Ratcliffe K, Terman B. Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling. FASEB J. 2002;16:1283-5 pubmed
    ..Evidence is provided in this manuscript that indicates a role for the fibroblast growth factor receptor substrate 2 (FRS2) in VEGF-induced signal transduction...
  37. Tomasovic A, Traub S, Tikkanen R. Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS ONE. 2012;7:e29739 pubmed publisher
    b>Fibroblast growth factor receptor substrate 2 (FRS2?) is a signaling adaptor protein that regulates downstream signaling of many receptor tyrosine kinases...
  38. Gu N, Eyo U, Murugan M, Peng J, Matta S, Dong H, et al. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain Behav Immun. 2016;55:82-92 pubmed publisher
    ..microglial electrophysiological and morphological (static and dynamic) activation during spinal nerve transection (SNT)-induced neuropathic pain in mice...
  39. Anaya Prado R, Valero Padilla C, Sarralde Delgado A, Sánchez González J, Montes Velázquez L, Gil Villarreal F. [Early neonatal sepsis and associated factors]. Rev Med Inst Mex Seguro Soc. 2017;55:317-323 pubmed
    ..Conocer los factores asociados a sepsis neonatal temprana (SNT) permite iniciar un tratamiento oportuno y tomar medidas preventivas...
  40. Tavares G, Martins M, Correia J, Sardinha V, Guerra Gomes S, das Neves S, et al. Employing an open-source tool to assess astrocyte tridimensional structure. Brain Struct Funct. 2017;222:1989-1999 pubmed publisher
    ..In this study, we optimized and validated the FIJI-ImageJ, Simple Neurite Tracer (SNT) plugin, an open-source software that aids in the reconstruction of GFAP-stained structure of astrocytes...
  41. Uchida H, Matsumura S, Okada S, Suzuki T, Minami T, Ito S. RNA editing enzyme ADAR2 is a mediator of neuropathic pain after peripheral nerve injury. FASEB J. 2017;31:1847-1855 pubmed publisher
    ..Seven days after L5 spinal nerve transection (SNT) in adult mice, we found an increase in ADAR2 expression and a decrease in ADAR3 expression in the injured, but not ..
  42. Yoles Frenkel M, Cohen O, Bansal R, Horesh N, Ben Shaul Y. In vivo stimulus presentation to the mouse vomeronasal system: Surgery, experiment, setup, and software. J Neurosci Methods. 2017;285:19-32 pubmed publisher
    ..VNO suction is achieved via electrical stimulation of the sympathetic nerve trunk (SNT) using cuff electrodes, followed by flushing of the nasal cavity...
  43. Sun P, Xue C, Li L, Shao C, An X, Thomas R, et al. The renal safety and efficacy of combined gemcitabine plus cisplatin and gemcitabine plus carboplatin chemotherapy in Chinese patients with a solitary kidney after nephroureterectomy. Cancer Chemother Pharmacol. 2017;80:37-44 pubmed publisher
    ..Severe nephrotoxicities (SNTs) were reported in 12 patients on GP (25%) and zero on GC. SNT risk factors included a more than 20% decrease in eGFR after one GP cycle and the presence of diabetes (all p <..
  44. Sharma K, Kalyani I, Mohapatra J, Patel S, Patel D, Vihol P, et al. Evaluation of the oncolytic potential of R2B Mukteshwar vaccine strain of Newcastle disease virus (NDV) in a colon cancer cell line (SW-620). Arch Virol. 2017;162:2705-2713 pubmed publisher
    ..Antibody titer and virus survival were measured by hemagglutination inhibition (HI)/serum neutralization test (SNT) and real-time PCR, respectively...
  45. Li X, Brunton V, Burgar H, Wheldon L, Heath J. FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci. 2004;117:6007-17 pubmed
    ..This event requires the presence of the signalling adaptor fibroblast growth factor receptor substrate 2 (FRS2). The phosphorylation of hSpry2 is therefore mediated by an intermediate kinase...
  46. Wabnig S, Liewald J, Yu S, Gottschalk A. High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans. PLoS ONE. 2015;10:e0135584 pubmed publisher
    ..of genes affecting SV recycling (unc-26 synaptojanin, unc-41 stonin, unc-57 endophilin, itsn-1 intersectin, snt-1 synaptotagmin) showed a distinct 'signature' of muscle Ca2+ dynamics, induced by cholinergic motoneuron ..
  47. Peng J, Gu N, Zhou L, B Eyo U, Murugan M, Gan W, et al. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nat Commun. 2016;7:12029 pubmed publisher
    ..and temporally control the depletion of microglia and monocytes in a mouse model of spinal nerve transection (SNT)...
  48. Zhong X, Xie G, Zhang Z, Wang Z, Wang Y, Wang Y, et al. MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy. Oncotarget. 2016;7:61166-61182 pubmed publisher
    ..17, 95% confidence interval [CI] = 0.05~0.57, P = 0.004). Conversely, high expression of FRS2, the key adaptor protein required by FGFR signaling, predicted poor disease-free survival (DFS) (adjusted HR = 2...
  49. Li S, Liu G, Zheng M, Liu W, Li J, Wang M, et al. Unintentional production of persistent chlorinated and brominated organic pollutants during iron ore sintering processes. J Hazard Mater. 2017;331:63-70 pubmed publisher
    Iron ore sintering (SNT) processes are major sources of unintentionally produced chlorinated persistent organic pollutants (POPs), including polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), and ..
  50. Tauran Y, Tarhan M, Mollet L, Gerves J, Kumemura M, Jalabert L, et al. Elucidating the mechanism of the considerable mechanical stiffening of DNA induced by the couple Zn2+/Calix[4]arene-1,3-O-diphosphorous acid. Sci Rep. 2018;8:1226 pubmed publisher
    ..Silicon NanoTweezer (SNT) measurements show an increase in the mechanical stiffness of DNA bundles by a factor of >150, at Zn2+..
  51. Turner S, Bailey K, Fridley B, Chapman A, Schwartz G, Chai H, et al. Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic. Hypertension. 2008;52:359-65 pubmed publisher
    ..in proximity to lysozyme (LYZ), YEATS domain containing 4 (YEATS4), and fibroblast growth receptor substrate 2 (FRS2) were significantly associated with diastolic BP response (nominal P=2.39 x 10(-7); Bonferroni corrected P=0...
  52. Zhuang H, Zhang Y, Chu Z, Long J, An X, Zhang H, et al. Synergy of metal and nonmetal dopants for visible-light photocatalysis: a case-study of Sn and N co-doped TiO2. Phys Chem Chem Phys. 2016;18:9636-44 pubmed publisher
    ..The Sn and N co-doped TiO2 (SNT-x) photocatalysts were successfully prepared by the facile sol-gel method and the post-nitridation route in the ..
  53. Roelandt S, Suin V, Van der Stede Y, Lamoral S, Marché S, Tignon M, et al. First TBEV serological screening in Flemish wild boar. Infect Ecol Epidemiol. 2016;6:31099 pubmed publisher
    ..Neutralising antibodies were titrated with a seroneutralisation test (SNT), using two cut-off titres (1/10-1/15)...
  54. Chemali M, Hibbert E, Sheen A. General practitioner understanding of abbreviations used in hospital discharge letters. Med J Aust. 2015;203:147, 147e.1-4 pubmed
    ..Six abbreviations were misinterpreted by more than a quarter of GPs. These were SNT (soft non-tender), TTE (transthoracic echocardiogram), EST (exercise stress test), NKDA (no known drug allergies), ..
  55. Mason J, Morrison D, Bassit B, Dimri M, Band H, Licht J, et al. Tyrosine phosphorylation of Sprouty proteins regulates their ability to inhibit growth factor signaling: a dual feedback loop. Mol Biol Cell. 2004;15:2176-88 pubmed
    ..tyrosine phosphorylation of Sprouty2 affected neither its subcellular localization nor its interaction with Grb2, FRS2/SNT, or other Sprouty proteins...
  56. Belleudi F, Leone L, Nobili V, Raffa S, Francescangeli F, Maggio M, et al. Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways. Traffic. 2007;8:1854-72 pubmed
    ..fate of KGFR might depend on the different ability of the receptor to phosphorylate the fibroblast growth factor receptor substrate 2 (FRS2) substrate and to recruit the ubiquitin ligase c-Cbl...
  57. Krejci P, Masri B, Salazar L, Farrington Rock C, Prats H, Thompson L, et al. Bisindolylmaleimide I suppresses fibroblast growth factor-mediated activation of Erk MAP kinase in chondrocytes by preventing Shp2 association with the Frs2 and Gab1 adaptor proteins. J Biol Chem. 2007;282:2929-36 pubmed
    ..of MEK, Raf-1, and Ras members of Erk signaling module but not the FGF2-induced tyrosine phosphorylation of Frs2 or the kinase activity of FGFR3, demonstrating that it targets the Erk cascade immediately upstream of Ras...
  58. Lu F, Ogawa R, Nguyen D, Chen B, Guo D, Helm D, et al. Microdeformation of three-dimensional cultured fibroblasts induces gene expression and morphological changes. Ann Plast Surg. 2011;66:296-300 pubmed publisher
    ..Microdeformations produced by the combination of polyurethane foam and suction are associated with increased fibroblast proliferation and up-regulation of gene expressions in fibroblasts. ..
  59. Lu T, Lin B, Li Y, Arora A, Han L, Cui C, et al. Overexpression of microRNA-1 promotes cardiomyocyte commitment from human cardiovascular progenitors via suppressing WNT and FGF signaling pathways. J Mol Cell Cardiol. 2013;63:146-54 pubmed publisher
    ..FZD7 and FRS2 were confirmed as miR-1 targets using luciferase reporter assay and western blot...
  60. Li H, Tao C, Cai Z, Hertzler Schaefer K, Collins T, Wang F, et al. Frs2? and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci. 2014;127:571-82 pubmed publisher
    ..In this study, we used lens development as a model to investigate Frs2? and its structurally related scaffolding proteins, Gab1 and Gab2, in FGF signaling...
  61. Chen P, Qin L, Zhuang Z, Tellides G, Lax I, Schlessinger J, et al. The docking protein FRS2? is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A. 2014;111:5514-9 pubmed publisher
    ..We report that the docking protein fibroblast growth factor receptor substrate 2 (FRS2?) plays a critical role in cell signaling via these receptors...
  62. Cousin S, Grellety T, Toulmonde M, Auzanneau C, Khalifa E, Laizet Y, et al. Clinical impact of extensive molecular profiling in advanced cancer patients. J Hematol Oncol. 2017;10:45 pubmed publisher
    ..KRAS, PTEN, PI3KCA, RB1, APC, ERBB2, MYC, EGFR, CDKN2B, ARID1A, SMAD4, FGFR1, MDM2, BRAF, ATM, CCNE1, FGFR3 and FRS2. One hundred fifty-nine patients (28%) were included in early phase trials...
  63. Zhang L, Zhao Z, Xu S, Tandon M, LaValle C, Deng F, et al. Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells. Oncotarget. 2017;8:12800-12811 pubmed publisher
    ..Downstream of AR, we identified fibroblast growth factor receptor substrate 2 (FRS2) and its downstream MEK/ERK pathway as mediators of androgen-induced PKD1 repression...
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    ..FGFRs, Trks, Alk and Ret, are currently known to transduce a signal through a docking protein, fibroblast growth factor receptor substrate 2? (FRS2?). However, nothing has been reported about the interaction of FRS2? with EphA4...
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    Membrane-anchored adaptor proteins FRS2alpha/beta (also known as SNT-1/2) mediate signaling of fibroblast growth factor receptors (FGFRs) and neurotrophin receptors (TRKs) through their N-terminal phosphotyrosine binding (PTB) domains...
  69. Cheung J, Samartzis D, Yeung K, To M, Luk K, Cheung K. A randomized double-blinded clinical trial to evaluate the safety and efficacy of a novel superelastic nickel-titanium spinal rod in adolescent idiopathic scoliosis: 5-year follow-up. Eur Spine J. 2018;27:327-339 pubmed publisher
    To evaluate the safety and efficacy of a superelastic shape-memory alloy (SNT) rod used in the treatment of adolescent idiopathic scoliosis (AIS)...
  70. Nandi S, Alviña K, Lituma P, Castillo P, Hebert J. Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis. Neuroscience. 2018;369:192-201 pubmed publisher
    ..that a module of neurotrophin and FGF signaling, the FGF Receptor Substrate (FRS) family of intracellular adapters, FRS2 and FRS3, are together required for postnatal brain development...
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    ..pp66.GRB2.Sos; these two complexes may alternatively link FGFG3 to mitogen-activated protein kinase. Finally, activated FGFR3 was also found to result in phosphorylation of phospholipase C-gamma but reduced phosphorylation of c-Src. ..
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    ..recruitment of the Grb2-Sos complex either to the fibroblast growth factor receptor (FGFR) docking adaptor protein FRS2 or to Shp2...
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    ..share many common protein substrates that are used by other receptor tyrosine kinases (RTK), such as Shc, Grb2, FRS2, and phospholipase C-gamma...
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    ..In addition, phosphorylation of its associated molecules FRS2 and c-Src were examined in the presence and absence of the ROS and pathway specific inhibitors...
  77. Luo L, Kim E, Cheung H, Weir B, Dunn G, Shen R, et al. The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer. Mol Cancer Res. 2015;13:502-9 pubmed publisher
    ..b>FRS2 is one of the 50 genes located on chromosomal region 12q15 that is focally amplified in 12.5% of HGSOC...
  78. Darville N, Van Heerden M, Mariën D, De Meulder M, Rossenu S, Vermeulen A, et al. The effect of macrophage and angiogenesis inhibition on the drug release and absorption from an intramuscular sustained-release paliperidone palmitate suspension. J Control Release. 2016;230:95-108 pubmed publisher
    ..Liposomal clodronate (CLO) and sunitinib (SNT) were co-administered to inhibit the depot infiltration and nano-/microparticle phagocytosis by macrophages, and ..
  79. Shams Z, Khalatbary A, Ahmadvand H, Zare Z, Kian K. Neuroprotective effects of hyperbaric oxygen (HBO) therapy on neuronal death induced by sciatic nerve transection in rat. BMC Neurol. 2017;17:220 pubmed publisher
    ..The purpose of this study was to determine the neuroprotective effects of HBO following sciatic nerve transection (SNT)...
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    ..These differing responses point to a complex interplay between neurotrophin-stimulated survival, differentiation, and apoptosis pathways. ..
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    The signaling adapter proteins FRS2 and FRS3 are implicated in the transmission of extracellular signals from nerve growth factor (NGF) or fibroblast growth factor (FGF) receptors to the Ras/mitogen-activated protein kinase signaling ..
  82. Lundgren T, Stenqvist A, Scott R, Pawson T, Ernfors P. Cell migration by a FRS2-adaptor dependent membrane relocation of ret receptors. J Cell Biochem. 2008;104:879-94 pubmed publisher
    ..cells is elicited by the activation of specific signaling pathways initiated by the competitive recruitment of the FRS2 adaptor molecule to tyrosine 1062 (Y1062) in RET...
  83. Butty A, Frischknecht M, Gredler B, Neuenschwander S, Moll J, Bieber A, et al. Genetic and genomic analysis of hyperthelia in Brown Swiss cattle. J Dairy Sci. 2017;100:402-411 pubmed publisher
    Supernumerary teats (SNT) are any abnormal teats found on a calf in addition to the usual and functional 4 teats. The presence of SNT has also been termed "hyperthelia" since the end of the 19th century...
  84. Sui X, Zhang C, Zhou J, Cao S, Xu C, Tang F, et al. Resveratrol inhibits Extranodal NK/T cell lymphoma through activation of DNA damage response pathway. J Exp Clin Cancer Res. 2017;36:133 pubmed publisher
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  85. Wu X, Zheng M, Zhao Y, Yang H, Yang L, Jin R, et al. Thermochemical formation of polychlorinated dibenzo-p-dioxins and dibenzofurans on the fly ash matrix from metal smelting sources. Chemosphere. 2018;191:825-831 pubmed publisher
    ..on fly ash from typical multiple secondary aluminum (SAl), secondary lead (SPb) smelting, and iron ore sintering (SNT) sources in China...
  86. Breard E, Schulz C, Sailleau C, Bernelin Cottet C, Viarouge C, Vitour D, et al. Bluetongue virus serotype 27: Experimental infection of goats, sheep and cattle with three BTV-27 variants reveal atypical characteristics and likely direct contact transmission BTV-27 between goats. Transbound Emerg Dis. 2017;: pubmed publisher
    ..Surprisingly, BTV-Ab levels as measured with ELISA and neutralization test (SNT) were remarkably low in all seropositive goats...
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    ..by specific inhibition of the phosphorylation of two signal transducers that act downstream of the FGF receptor, FRS2 and a 180 kDa protein, and by prevention of their interaction with the adaptor protein GRB2...
  88. Lao D, Chandramouli S, Yusoff P, Fong C, Saw T, Tai L, et al. A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation. J Biol Chem. 2006;281:29993-30000 pubmed
    ..We present evidence that Spry2 can compete with the RasGEF (guanine nucleotide exchange factor) SOS1 for binding to Grb2, resulting in the inhibition of phosphorylation of ERK1/2. ..
  89. Larsson H, Klint P, Landgren E, Claesson Welsh L. Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk. J Biol Chem. 1999;274:25726-34 pubmed
    ..Our data indicate that Crk participates in signaling complexes downstream of FGFR-1, which propagate mitogenic signals. ..
  90. Foehr E, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, et al. Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors. FASEB J. 2000;14:973-81 pubmed
    ..with DDR1 JM sequences (with and without the insert) indicated that the shorter sequence bound and activated FRS2 whereas the insert-containing form activated Shc instead...
  91. Zhou L, Talebian A, Meakin S. The signaling adapter, FRS2, facilitates neuronal branching in primary cortical neurons via both Grb2- and Shp2-dependent mechanisms. J Mol Neurosci. 2015;55:663-77 pubmed publisher
    ..receptors) and utilize an intracellular docking protein termed fibroblast growth factor (FGF) receptor substrate 2 (FRS2) as a major downstream adapter to activate Ras, phosphatidylinositide 3-kinase (PI3K), and mitogen-activated ..
  92. Li J, Shi S, Srivastava S, Kitada M, Nagai T, Nitta K, et al. FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway. Cell Death Dis. 2017;8:e2965 pubmed publisher
    ..effects of AcSDKP were lost following treatment with a neutralizing FGFR1 antibody (N-FGFR1) or transfection of FRS2 siRNA...