FPR1

Summary

Gene Symbol: FPR1
Description: formyl peptide receptor 1
Alias: FMLP, FPR, N-formylpeptide chemoattractant receptor, fMLP receptor, fMet-Leu-Phe receptor
Species: human

Top Publications

  1. ncbi Cellular responses to FMLP challenging: a mini-review
    M A Panaro
    Department of Human Anatomy, University of Bari, Italy
    Immunopharmacol Immunotoxicol 21:397-419. 1999
  2. ncbi Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors
    Brian A Babbin
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 281:19588-99. 2006
  3. ncbi Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients
    Y Zhang
    Center for Craniofacial and Dental Genetics, University of Pittsburg School of Dental Medicine, Pittsburg, PA 15261, USA
    Genes Immun 4:22-9. 2003
  4. ncbi Sequence and organization of the human N-formyl peptide receptor-encoding gene
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Gene 133:285-90. 1993
  5. ncbi Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression
    H D Perez
    Department of Medicine, University of California, San Francisco 94143
    Biochemistry 31:11595-9. 1992
  6. ncbi Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
  7. ncbi Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 30:348-55. 2009
  8. ncbi Variable responses of formyl peptide receptor haplotypes toward bacterial peptides
    Jeannie M Gripentrog
    Department of Microbiology, Montana State University, MT 59717, USA
    Immunogenetics 60:83-93. 2008
  9. ncbi Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis
    R Seifert
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045 2505, USA
    J Biol Chem 276:42043-9. 2001
  10. ncbi Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4
    T Christophe
    DRCD BBSI UMR 5092, CEA CNRS UJF, Grenoble, Cedex, France
    Scand J Immunol 56:470-6. 2002

Research Grants

  1. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Gerardo Hernandez; Fiscal Year: 2004
  2. Effects of Formyl Peptide Receptor variants on function
    John Mills; Fiscal Year: 2005
  3. Molecular Mechanism of Leukocyte Activation
    Richard Ye; Fiscal Year: 2007
  4. Structure-Function Studies of Annexin I and II
    Hartmut Luecke; Fiscal Year: 2006
  5. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2006
  6. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2003
  7. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2007
  8. Membrane Organization in Cell Signaling and Adhesion
    Tione Buranda; Fiscal Year: 2007
  9. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2009
  10. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    JULIAN GOMEZ CAMBRONERO; Fiscal Year: 2010

Detail Information

Publications201 found, 100 shown here

  1. ncbi Cellular responses to FMLP challenging: a mini-review
    M A Panaro
    Department of Human Anatomy, University of Bari, Italy
    Immunopharmacol Immunotoxicol 21:397-419. 1999
    b>FMLP (N-formyl-methionyl-leucyl-phenylalanine) and other N-formylpeptides are powerful "activators" of polymorphonuclear and mononuclear phagocytes, but they are also active on other cell types...
  2. ncbi Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors
    Brian A Babbin
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 281:19588-99. 2006
    ..migratory events through interactions with n-formyl peptide receptors (nFPRs), we examined the expression of FPR-1, FPRL-1, and FPRL-2 in SKCO-15 cells by reverse transcriptase-PCR and identified expression of all three ..
  3. ncbi Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients
    Y Zhang
    Center for Craniofacial and Dental Genetics, University of Pittsburg School of Dental Medicine, Pittsburg, PA 15261, USA
    Genes Immun 4:22-9. 2003
    ..The high-affinity fMLP receptor (FPR1) of phagocytic cells interacts with bacterial fMLP and mediates chemotaxis, degranulation, and ..
  4. ncbi Sequence and organization of the human N-formyl peptide receptor-encoding gene
    P M Murphy
    Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
    Gene 133:285-90. 1993
    The human FPR1 gene encodes the N-formyl peptide receptor, a G protein-coupled receptor (GPCR) that mediates the activation of mature myeloid cells by bacterial N-formyl oligopeptides...
  5. ncbi Cloning of the gene coding for a human receptor for formyl peptides. Characterization of a promoter region and evidence for polymorphic expression
    H D Perez
    Department of Medicine, University of California, San Francisco 94143
    Biochemistry 31:11595-9. 1992
    Recently we reported that, in HL-60 cells, transcription of the formyl peptide receptor (FPR) gene can be up- and downregulated by agents that induce differentiation of HL-60 cells into neutrophils...
  6. ncbi Formylpeptide receptor FPR and the rapid growth of malignant human gliomas
    Ye Zhou
    Laboratory of Molecular Immunoregulation, CCR, NCI Frederick, Building 560, Room 31 40, Frederick, MD 21702 1201, USA
    J Natl Cancer Inst 97:823-35. 2005
    The formylpeptide receptor (FPR) is a G-protein-coupled receptor (GPCR) that mediates chemotaxis of phagocytic leukocytes induced by bacterial peptide N-formyl-methionyl-leucyl-phenylalanine (fMLF)...
  7. ncbi Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation
    Jian Huang
    Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA
    Carcinogenesis 30:348-55. 2009
    The G protein-coupled formylpeptide receptor (FPR), known to mediate phagocytic leucocyte chemotaxis in response to bacterial- and host-derived agonists, was expressed by tumor cells in specimens of surgically removed more highly ..
  8. ncbi Variable responses of formyl peptide receptor haplotypes toward bacterial peptides
    Jeannie M Gripentrog
    Department of Microbiology, Montana State University, MT 59717, USA
    Immunogenetics 60:83-93. 2008
    ..We also investigated whether certain FPR haplotypes are associated with rheumatoid arthritis (RA) by sequencing FPR1 from 148 Caucasian individuals. The results suggested that FPR haplotypes do not significantly contribute toward RA.
  9. ncbi Defective Gi protein coupling in two formyl peptide receptor mutants associated with localized juvenile periodontitis
    R Seifert
    Department of Pharmacology and Toxicology, University of Kansas, Lawrence, Kansas 66045 2505, USA
    J Biol Chem 276:42043-9. 2001
    The formyl peptide receptor (FPR) is a prototypical chemoattractant receptor expressed in neutrophils...
  10. ncbi Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4
    T Christophe
    DRCD BBSI UMR 5092, CEA CNRS UJF, Grenoble, Cedex, France
    Scand J Immunol 56:470-6. 2002
    Lipoxin A4 (LXA4) has been shown to bind to the leucocyte formyl peptide receptor (FPR) homologue, FPRL1, without triggering the biological activities induced by other FPRL1 agonists...
  11. ncbi Vasoactive drugs inhibit oxygen radical production of neutrophils
    M Weiss
    Department of Anesthesiology, , Ulm
    Immunopharmacol Immunotoxicol 19:239-63. 1997
    ..with neutrophils from healthy human volunteers, which were stimulated by N-formyl-methionyl-leucyl-phenylalanine (FMLP) and by opsonized zymosan to produce oxygen radicals, detected by chemiluminescence measurements...
  12. ncbi Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions
    A Hatzelmann
    Byk Gulden, Department of Biochemistry, Konstanz, Germany
    Br J Pharmacol 114:821-31. 1995
    ..From the stimuli investigated (complement C5a; N-formyl-methionyl-leucyl-phenylalanine, fMLP; platelet activating factor, PAF; opsonized zymosan) C5a was selected to test the influence of the above mentioned ..
  13. ncbi beta-Lactam antibiotic modulation of murine neutrophil cytokinesis
    M T Kenny
    Marion Merrell Dow Research Institute, Indianapolis, Indiana 46268-0460
    Immunopharmacol Immunotoxicol 14:797-811. 1992
    ..As a result, the beta-lactam antibiotics were placed into 6 groups based on their effect on random (R) and FMLP-directed (D) migration [Group 1 (no effect): cephalosporin C; Group 2 (R-->D decreases): cloxacillin, cefotaxime,..
  14. ncbi Modulation of cytoskeleton assembly capacity and oxidative response in aged neutrophils
    G Piazzolla
    Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari Medical School, Italy
    Immunopharmacol Immunotoxicol 20:251-66. 1998
    ..an impairment of superoxide anion (O2-) generation when triggered with formyl-methionyl-leucine-phenylalanine (FMLP) in comparison to the younger counterpart...
  15. ncbi GABA-mediated inhibition of the anaphylactic response in the guinea-pig trachea
    G Gentilini
    Department of Preclinical and Clinical Pharmacology Mario Aiazzi Mancini, University of Florence, Italy
    Br J Pharmacol 115:389-94. 1995
    ..The release of platelet-activating factor (PAF) from alveolar macrophages stimulated by formyl-Met-Leu-Phe (FMLP; 1 microM) was modified neither by GABA (100 microM)nor by (-)-baclofen (100microM).5...
  16. ncbi Effects of two antihypertensive agents, labetalol and metoprolol, on the production of reactive oxygen species by normal polymorphonuclear leukocytes in vitro
    R Jaboureck-Bouttier
    Laboratoire de Pharmacologie, , Lille, France
    Hypertens Pregnancy 18:239-47. 1999
    ..stimulated in vitro with phorbol-12-myristate-13-acetate (PMA) and N-formyl-methionin-leucin-phenylalanin (fMLP). We also studied the scavenging properties of these two drugs using acellular systems...
  17. ncbi Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action
    H Yarwood
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 108:959-66. 1993
    ..d. zymosan activated plasma (ZAP), N-formyl-methionyl-leucyl-phenylalanine (FMLP) and leukotriene B4 (LTB4) when co-injected with prostaglandin E2 (PGE2)...
  18. ncbi Carbamazepine affects neutrophil function through an action on peripheral benzodiazepine receptors
    E Caldiroli
    Department of Internal Medicine and Therapeutics, University of Pavia, Italy
    Immunopharmacol Immunotoxicol 19:367-82. 1997
    ..42-168 microM) concentration-dependently inhibited chemotaxis induced by N-formyl-methionyl-leucyl-phenylalanine (FMLP) or lipopolysaccharide (LPS)-activated human serum...
  19. ncbi Inhibitory effects of local anesthetics on migration, extracellular release of lysosomal enzyme, and superoxide anion production in human polymorphonuclear leukocytes
    S Sasagawa
    Department of Pathology, Radiation Effects Research Foundation, Hiroshima, Japan
    Immunopharmacol Immunotoxicol 13:607-22. 1991
    ..PMN were stimulated by fMet-Leu-Phe (FMLP) or phorbol myristate acetate (PMA) to elicit chemotaxis, extracellular release of beta-glucuronidase (BGL) and ..
  20. ncbi Reactive oxygen species in essential hypertension and non-insulin-dependent diabetes mellitus
    N N Orie
    , University of Bochum, Germany
    Am J Hypertens 12:1169-74. 1999
    ..03+/-0.22 nmol/10(6) cells) or controls (4.05+/-0.15 nmol/10(6) cells). The formyl-Met-Leu-Phenylalanine-(fMLP)-induced ROS generation was significantly higher in NIDDM (21.92+/-2.23 nmol/10(6) cells; P<...
  21. ncbi The reaction of Campylobacter species on the chemiluminescence, chemotaxis and hemagglutination
    U Ullmann
    Department of Medical Microbiology, University of Kiel, FRG
    Zentralbl Bakteriol Mikrobiol Hyg A 266:178-90. 1987
    ..cultures were used as cytotoxins and compared with the chemotactic peptide, formyl-methionyl-leucine-phenylalanine (FMLP). All the supernatants of cultures of Campylobacter sp. were chemotactic for PMNG...
  22. ncbi [A study of enhancing effects of monocyte culture supernatant on polymorphonuclear neutrophils-chemiluminescence--comparison between normal controls and collagen disease patients]
    Y Shimatsu
    Department of Medicine (II, Niigata University Medical School, Japan
    Kansenshogaku Zasshi 66:679-85. 1992
    ..In normal controls, N-formyl-methionyl-leucyl-phenylalanine (FMLP) induced PMN-CL was enhanced when PMN were previously incubated for 15 minutes with monocyte culture supernatant (..
  23. ncbi Strain-dependency of leukotriene C4 generation from isolated lungs of immunized mice
    C Zuany Amorim
    , , INSERM No 285, Paris, France
    Br J Pharmacol 112:1230-6. 1994
    ..However, N-formyl-L-methionyl-L-leucyl-L- phenylalanine (fMLP, 0...
  24. ncbi The effect of cyclic AMP and cyclic GMP phosphodiesterase inhibitors on the superoxide burst of guinea-pig peritoneal macrophages
    N C Turner
    Dagenham Research Centre, Rhone Poulenc Rorer Ltd, Dagenham, Essex
    Br J Pharmacol 108:876-83. 1993
    ..6 +/- 3.76% by 1 microM salbutamol. 3. The increase in superoxide generation elicited by FMLP (10(-9)-10(-5)M) was unaffected by any of the PDE inhibitors studied...
  25. ncbi Hydrogen peroxide modulation of the superoxide anion production by stimulated neutrophils
    I Dekaris
    Department of Ophthalmology, GH "Sveti Duh, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 20:103-17. 1998
    ..This effect was not observed when phorbol myristate acetate (PMA), formyl-methionyl-leucyl-phenylalanine (fMLP) or tumor necrosis factor alpha (TNF alpha) were used as a stimuli...
  26. ncbi Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505
    F Pons
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 109:234-42. 1993
    ..not affect oedema induced by zymosan particles, bradykinin (BK), histamine, formyl-methionyl-leucylphenylalanine (FMLP), zymosan-activated plasma (ZAP, as a source of C5a des Arg), leukotriene B4 (LTB4) or interleukin-8 (IL-8). 4...
  27. ncbi Effects of the angiotensin converting enzyme inhibitor temocapril on insulin sensitivity and its effects on renal sodium handling and the pressor system in essential hypertensive patients
    Y Miyazaki
    Second Department of Internal Medicine, Sapporo Medical University School of Medicine, Japan
    Am J Hypertens 11:962-70. 1998
    ..and paraaminohippuric acid were used to calculate fractional proximal and distal tubular reabsorption of sodium (FPR(Na), FDR(Na)) and renal plasma flow (RPF) before and during insulin infusion by the glucose clamp method...
  28. ncbi Methionine-enkephalin primes human neutrophils for enhanced superoxide anion production
    H Haberstock
    Department of Experimental Biology and Medicine, Laboratory for Biological Response Modifiers, Zagreb, Croatia
    Immunopharmacol Immunotoxicol 19:135-45. 1997
    ..but it enhanced the O2- generation stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) or human recombinant interferon gamma (hrIFN gamma) when the cells had been preincubated with MENK for 30 min at ..
  29. ncbi Do etomidate and propofol influence oxygen radical production of neutrophils?
    M Weiss
    Department of Anesthesiology, Universitatsklinikum, Ulm, Germany
    Immunopharmacol Immunotoxicol 18:291-307. 1996
    ..alcoholic vehicle and in a lipid-emulsion as well as those of propofol on N-formyl-methionyl-leucyl-phenylalanine (FMLP-) and zymosan-induced oxygen radical production of neutrophils were examined and compared with the effects of their ..
  30. ncbi Benzodiazepines inhibit in vitro free radical formation from human neutrophils induced by FMLP and A23187
    F Laghi Pasini
    Department of Internal Medicine, University of Siena, Italy
    Immunopharmacol Immunotoxicol 9:101-14. 1987
    ..superoxide anion generation and chemiluminescence from human neutrophils stimulated by the formylated oligopeptide FMLP and by the calcium ionophore A23187...
  31. ncbi [Studies on defense effects of recombinant human granulocyte colony-stimulating factor (G-CSF) to infections. II. Priming effect for superoxide production by human neutrophil]
    J Kadota
    Second Department of Internal Medicine, Nagasaki University School of Medicine
    Kansenshogaku Zasshi 64:430-5. 1990
    ..with enhance of O2- release stimulated by the chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine (FMLP) from 10(-6) to 10(-8) M, but not by the non chemoattractant such as phorbol myristate acetate (PMA), concanavalin ..
  32. ncbi Sulfide influence on polymorphonuclear functions: a possible role for Ca2+ involvement
    M A Mariggio
    Department of Biomedical Sciences and Human Oncology, Faculty of Medicine, University of Bari, Italy
    Immunopharmacol Immunotoxicol 19:393-404. 1997
    ..of the calcium-dependent cytoskeleton activities such as chemotaxis and azurophilic granule release induced by FMLP. No effect was observed on the calcium-independent specific granule release obtained by PMA...
  33. ncbi Flavonoid modulation of murine neutrophil cytokinesis
    M T Kenny
    MerrellDow Research Institute, Indianapolis, Indiana 46268-0460
    Immunopharmacol Immunotoxicol 12:527-41. 1990
    ..In this study, flavone and six hydroxylated analogues were examined for their effect on the FMLP-directed and the random migration of murine peritoneal exudate neutrophils. Flavone significantly (p less than 0...
  34. ncbi Enhancing and priming of macrophages for superoxide anion production by taxol
    H O Pae
    Department of Microbiology and Immunology, Wonkwang University School of Medicine, Chonbuk, Korea
    Immunopharmacol Immunotoxicol 20:27-37. 1998
    ..7 cells to enhance O2- release stimulated with PMA. Taxol also enhanced stimulation of O2- production by FMLP, but not by Con A...
  35. ncbi Enhancing and inhibitory effects of nitric oxide on superoxide anion generation in human polymorphonuclear leukocytes
    M Morikawa
    Department of Pharmacology, Tokyo College of Pharmacy, Hachioji, Japan
    Br J Pharmacol 115:1302-6. 1995
    ..showed a biphasic concentration-dependent effect on O2- generation induced by f-methionyl-leucyl-phenylalanine (FMLP)...
  36. ncbi Expression of annexin-1 in equine leucocytes and the effects of the N-terminal annexin-1 peptide, Ac2-26, on equine neutrophil superoxide production
    Kirstie J Pickles
    Department of Veterinary Basic Sciences, The Royal Veterinary College, Hawkshead Campus, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA, UK
    Vet Immunol Immunopathol 135:226-33. 2010
    ..reduction of cytochrome (cyt) C following stimulation with Ac2-26 and the formyl peptide receptor (FPR) agonists, FMLP, WKYMVm and WKYMVM...
  37. ncbi Differential contribution of bacterial N-formyl-methionyl-leucyl- phenylalanine and host-derived CXC chemokines to neutrophil infiltration into pulmonary alveoli during murine pneumococcal pneumonia
    Jean François Gauthier
    Research Center for Infectious Diseases, Laval University, Quebec, Canada G1V 4G2
    Infect Immun 75:5361-7. 2007
    ..Bacterium-derived N-formyl peptides (N-formyl-methionyl-leucyl-phenylalanine [fMLP]) and host-derived chemokines (KC and macrophage inflammatory protein 2 [MIP-2]) are likely candidates among ..
  38. ncbi Similar age-related changes of free intracellular calcium in lymphocytes and central neurons: effects of Alzheimer's disease
    H Hartmann
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    Eur Arch Psychiatry Clin Neurosci 243:218-23. 1994
    ..Also no age-related or AD-specific changes were found in granulocytes after stimulation with N-formyl-methionyl-leucyl-phenylalanine (fMLP).(ABSTRACT TRUNCATED AT 250 WORDS)
  39. ncbi Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
    E Talpain
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 114:1459-65. 1995
    ..receptor subtype mediating the inhibition of superoxide anion generation by formyl methionyl leucine phenylalanine (FMLP)-stimulated human neutrophils, and to test the hypothesis that adenosine 3':5'-cyclic monophosphate (cyclic AMP) is ..
  40. ncbi Membrane depolarization was required to induce DNA synthesis in murine macrophage cell line PU5-1.8
    S K Kong
    Department of Biochemistry, Chinese University of Hong Kong, Shatin
    Immunopharmacol Immunotoxicol 13:329-39. 1991
    ..calf serum (FCS), lipopolysaccharide (LPS), epidermal growth factor (EGF), N-formyl-methionyl-leucyl-phenylalanine (FMLP) and bradykinin (BK), only FCS caused DNA synthesis and membrane depolarization...
  41. ncbi Formyl peptide receptors on immune and nonimmune cells: analysis of sequence conservation in FPR genes
    M A Panaro
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Immunopharmacol Immunotoxicol 29:243-69. 2007
    ..We examined the patterns of conservation/mutation within the FPR group of genes, as studied in 16 mRNAs from different species...
  42. ncbi Effects of BX661A, a new therapeutic agent for ulcerative colitis, on chemotaxis and reactive oxygen species production in polymorphonuclear leukocytes in comparison with salazosulfapyridine and its metabolite sulfapyridine
    I Kimura
    Infusion Research Department, Hoechst Marion Roussel Ltd, Saitama, Japan
    Arzneimittelforschung 48:1163-7. 1998
    ..39, 2.17 mmol/l, respectively) and by N-formyl-methionyl-leucyl-phenylalanine (FMLP) with IC50 values of 0.55, 0.06 and 0.66 mmol/l, respectively...
  43. ncbi Chemotaxis of chinese hamster ovary cells expressing the human neutrophil formyl peptide receptor: role of signal transduction molecules and alpha5beta1 integrin
    H M Miettinen
    Department of Microbiology, Montana State University, Bozeman, MT 59717 3520, USA
    J Cell Sci 111:1921-8. 1998
    ..N-formyl peptide receptor (FPR) of human neutrophils by ligands such as N-formyl-methionine-leucine-phenylalanine (fMLP) induces mobilization of intracellular calcium, cell adhesion, chemotaxis, superoxide production and degranulation...
  44. ncbi Decreased agonist-stimulated Ca2+ response in neutrophils from patients under chronic lithium therapy
    U Förstner
    Department of Psychiatry, University of Freiburg, Germany
    Eur Arch Psychiatry Clin Neurosci 243:240-3. 1994
    ..Cells were stimulated with the chemotactic peptide formylmethionylleucylphenylalanin (fMLP) and the Ca2+ concentrations measured with the fluorescent Ca2+ indicator Fura-2...
  45. ncbi Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:sugar phosphotransferase system and analysis of fructose (fru) operon expression in Salmonella typhimurium
    D A Feldheim
    Department of Biology, University of California, San Diego, La Jolla 92093
    J Bacteriol 172:5459-69. 1990
    ..The fru operon consists of three structural genes: fruB(MH), which encodes the enzyme IIIFru-modulator-FPr tridomain fusion protein of the PTS; fruK, which encodes fructose-1-phosphate kinase; and fruA, which encodes ..
  46. ncbi The N-formyl peptide receptors and the anaphylatoxin C5a receptors: an overview
    Marie Josephe Rabiet
    Laboratoire de Biochimie et de Biophysique des Systèmes Intégrés, CEA, CNRS, Universite Joseph Fourier, Institut de Recherches en Technologies et Sciences pour le Vivant iRTSV, Commissariat a l Energie Atomique Grenoble, 38054 Grenoble Cedex 9, France
    Biochimie 89:1089-106. 2007
    ..Emphasis is placed on the members of the N-formyl peptide receptor family, namely FPR (N-formyl peptide receptor), FPRL1 (FPR like-1) and FPRL2 (FPR like-2), and the complement fragment C5a receptors (..
  47. ncbi An fMLP receptor is involved in activation of phagocytosis by hemocytes from specific insect species
    Erick Garcia-Garcia
    Department of Immunology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    Dev Comp Immunol 33:728-39. 2009
    ..Treating hemocytes with Pertussis toxin, a known inhibitor of the signaling pathway initiated by the mammalian fMLP receptor, returned phagocytosis to basal levels...
  48. ncbi The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications
    R D Ye
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    J Immunol 150:1383-94. 1993
    ..receptors that share extensive sequence homology with the FPR, yet lack the capability of high affinity binding to FMLP. These findings prompted us to identify the structural requirement for formyl peptide ligand binding by delineation ..
  49. ncbi Gastrin-releasing peptide/neuromedin B receptor antagonists PD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors
    Igor A Schepetkin
    Department of Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    Mol Pharmacol 79:77-90. 2011
    ..ability to induce intracellular Ca²+ mobilization in human neutrophils and HL-60 cells transfected with human FPR1, FPR2, or FPR3...
  50. ncbi Mechanisms underlying reduced responsiveness of neonatal neutrophils to distinct chemoattractants
    B Weinberger
    Department of Pediatrics Neonatology, UMDNJ Robert Wood Johnson Medical School, Rutgers University, Piscataway, New Jersey, USA
    J Leukoc Biol 70:969-76. 2001
    ..2, was reduced in neonates when compared with adult cells. This did not appear to be a result of decreased fMLP receptor or DL1.2 antigen expression by neonatal neutrophils. fMLP, but not DL1...
  51. ncbi Quantitative analysis of formyl peptide receptor coupling to g(i)alpha(1), g(i)alpha(2), and g(i)alpha(3)
    K Wenzel-Seifert
    Higuchi Biosciences Center, The University of Kansas, Lawrence, Kansas 66045 2505, USA
    J Biol Chem 274:33259-66. 1999
    The human formyl peptide receptor (FPR) is a prototypical G(i) protein-coupled receptor, but little is known about quantitative aspects of FPR-G(i) protein coupling...
  52. ncbi N-formyl peptide receptors internalize but do not recycle in the absence of arrestins
    Charlotte M Vines
    Department of Cell Biology and Physiology, The University of New Mexico Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Biol Chem 278:41581-4. 2003
    ..To understand the role of arrestins in N-formyl peptide receptor (FPR) trafficking, we stably expressed the FPR in a mouse embryonic fibroblast cell line (MEF) that lacked endogenous ..
  53. ncbi HIV-1 envelope gp41 peptides promote migration of human Fc epsilon RI+ cells and inhibit IL-13 synthesis through interaction with formyl peptide receptors
    Amato de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    J Immunol 169:4559-67. 2002
    ..Preincubation of basophils with FMLP or gp41 2019 resulted in complete desensitization to a subsequent challenge with homologous stimulus...
  54. ncbi Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Wendlingweg 2, Aachen, Germany
    Mol Membr Biol 26:371-83. 2009
    ..In particular, the formyl peptide receptor (FPR) family and their three human subtypes: FPR, formyl-peptide-receptor-like-1 (FPRL1) and FPRL2, are involved in the ..
  55. ncbi Differential activation of polymorphisms of the formyl peptide receptor by formyl peptides
    John S Mills
    Montana State University, 109 Lewis Hall, Bozeman, MT 59717 3520, USA
    Biochim Biophys Acta 1772:1085-92. 2007
    ..the role of two polymorphic sites (R190W and N192K) on the binding and activation of the formyl peptide receptor (FPR) by viral and formyl peptides...
  56. ncbi Characterisation of receptor binding by the chemotaxis inhibitory protein of Staphylococcus aureus and the effects of the host immune response
    Andrew J Wright
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK
    Mol Immunol 44:2507-17. 2007
    ..human C5a receptor (C5aR), but had low affinity for the second C5a receptor, C5L2, and the formyl peptide receptor, FPR. Although ligand binding to C5aR was potently inhibited, CHIPS(28-149) had much weaker effects on ligand binding to ..
  57. ncbi Identification of putative sites of interaction between the human formyl peptide receptor and G protein
    H M Miettinen
    Department of Microbiology, Montana State University, Bozeman, Montana 59717 3520, USA
    J Biol Chem 274:27934-42. 1999
    ..All cell surface-expressed mutant receptors bound N-formyl peptide with similar affinities as wild-type FPR, suggesting that the mutations did not affect the ligand-binding site...
  58. ncbi The synthetic chemoattractant Trp-Lys-Tyr-Met-Val-DMet activates neutrophils preferentially through the lipoxin A(4) receptor
    C Dahlgren
    The Phagocyte Research Laboratory, Department of Medical Microbiology and Immunology, University of Goteborg, Goteborg, Sweden
    Blood 95:1810-8. 2000
    ..The fact that binding of fML[(3)H]F was inhibited by both fMLF and WKYMVm suggests that N-formyl peptide receptor (FPR) is shared by these peptides...
  59. ncbi The hederagenin saponin SMG-1 is a natural FMLP receptor inhibitor that suppresses human neutrophil activation
    Tsong Long Hwang
    Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
    Biochem Pharmacol 80:1190-200. 2010
    ..Taken together, our results demonstrate that SMG-1 is a natural inhibitor of the FMLP receptor, which may have the potential to be developed into a useful new therapeutic agent for treating neutrophilic ..
  60. ncbi Receptor cleavage reduces the fluid shear response in neutrophils of the spontaneously hypertensive rat
    Angela Y Chen
    Department of Bioengineering, Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093 0412, USA
    Am J Physiol Cell Physiol 299:C1441-9. 2010
    ..stress evokes pseudopod retraction in normal leukocytes by a mechanism that involves the formyl peptide receptor (FPR) as mechanosensor...
  61. ncbi In vitro and in vivo interactions of ferredoxin-NADP+ reductases in Pseudomonas putida
    Jinki Yeom
    Division of Environmental Science and Ecological Engineering, Korea University, Seoul 136 075
    J Biochem 145:481-91. 2009
    Ferredoxin-NADP(+) reductase (Fpr) is known to control NADP(+)/NADPH pool in proteobacteria. There is only one fpr gene present in most proteobacteria, but Pseudomonas putida has two Fprs (FprA and FprB)...
  62. ncbi Cyclic ADP-ribose mediates formyl methionyl leucyl phenylalanine (fMLP)-induced intracellular Ca(2+) rise and migration of human neutrophils
    Katsuya Morita
    Department of Dental Pharmacology, Hiroshima University Graduate School of Biomedical Sciences, Japan
    J Pharmacol Sci 106:492-504. 2008
    ..present study examined the ability of cADPR to mobilize Ca(2+) and mediate formyl methionyl leucyl phenylalanine (fMLP)-stimulated increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)) and migration in human neutrophils...
  63. ncbi The human formyl peptide receptor as model system for constitutively active G-protein-coupled receptors
    Roland Seifert
    Department of Pharmacology and Toxicology, The University of Kansas, Malott Hall, Room 5064, 1251 Wescoe Hall Drive, Lawrence, KS 66045 7582, USA
    Life Sci 73:2263-80. 2003
    ..The human formyl peptide receptor (FPR) exists in several isoforms (FPR-26, FPR-98 and FPR-G6) and activates chemotaxis and cytotoxic cell functions of ..
  64. ncbi Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition
    Liliya N Kirpotina
    Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717, USA
    Mol Pharmacol 77:159-70. 2010
    N-formyl peptide receptor (FPR1) and N-formyl peptide receptor-like 1 (FPRL1, now known as FPR2) are G protein-coupled receptors involved in host defense and sensing cellular dysfunction...
  65. ncbi A homolog of formyl peptide receptor-like 1 (FPRL1) inhibitor from Staphylococcus aureus (FPRL1 inhibitory protein) that inhibits FPRL1 and FPR
    Cristina Prat
    Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Immunol 183:6569-78. 2009
    ..protein inhibits neutrophil calcium mobilization and chemotaxis induced by the FPRL1-ligand MMK-1 and FPR-ligand fMLP. While its FPRL1-inhibitory activity lies in the comparable nanomolar range of FLIPr, its antagonism of the FPR is ..
  66. ncbi Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu
    J S Mills
    Department of Microbiology, Montana State University, Bozeman, Montana 59717, USA
    J Biol Chem 275:39012-7. 2000
    The formyl peptide receptor (FPR) is a chemotactic G protein-coupled receptor found on the surface of phagocytes. We have previously shown that the formyl peptide binding site maps to the membrane-spanning region (Miettinen, H. M...
  67. ncbi House dust mite allergen activates human eosinophils via formyl peptide receptor and formyl peptide receptor-like 1
    Lena Svensson
    Department of Clinical Bacteriology, Goteborg University, Goteborg, Sweden
    Eur J Immunol 37:1966-77. 2007
    ..g. the formyl peptide receptor (FPR), CC chemokine receptor 3 (CCR3) and leukotriene receptor B4 (LTB(4)R)...
  68. ncbi Mechanism of the protective effect of intraperitoneally administered agonists for formyl peptide receptors against chemotherapy-induced alopecia
    Takahiro Tsuruki
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Biosci Biotechnol Biochem 71:1198-202. 2007
    ..MMK-1, a selective agonist of formyl peptide receptor-like 1 (FPRL1) receptor, the low affinity subtype of the fMLP receptor, prevented the alopecia in neonatal rats induced by the anticancer agent etoposide...
  69. ncbi N-Formyl peptide receptor subtypes in human neutrophils activate L-plastin phosphorylation through different signal transduction intermediates
    Marie Helene Paclet
    Department of Medicine, Centre for Molecular Medicine, The Rayne Institute, University College London, UK
    Biochem J 377:469-77. 2004
    ..Two fMLP receptor subtypes were identified in neutrophils, characterized by a distinct sensitivity to fMLP and antagonistic ..
  70. ncbi Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages
    Palash Mandal
    Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Immunol 178:2542-8. 2007
    ..LY2 but not parthenolide blocked the LPS-induced stabilization of FPR1 mRNA...
  71. ncbi Structural relatedness between the 18S rRNA genes and the formyl peptide receptor genes: new insights into the phylogenesis of immune receptors
    M A Panaro
    Department of Human Anatomy and Histology, University of Bari, Italy
    Immunopharmacol Immunotoxicol 30:291-305. 2008
    ..sequences of all >or=7-base oligonucleotide identities occurring in at least one of the 18S rRNAs and one of the FPR mRNAs were recorded...
  72. ncbi Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils
    Thalie Devosse
    Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 182:4974-84. 2009
    The formyl peptide receptor (FPR) is a key player in innate immunity and host defense mechanisms. In humans and other primates, a cluster of genes encodes two related receptors, FPR-like 1 and FPR-like 2 (FPRL1 and FPRL2)...
  73. ncbi Interleukin-18 primes the oxidative burst of neutrophils in response to formyl-peptides: role of cytochrome b558 translocation and N-formyl peptide receptor endocytosis
    Carole Elbim
    Unité Inserm U479, Faculte de Medecine Xavier Bichat, 16 rue Henri Huchard, 75877 Paris Cedex 18, France
    Clin Diagn Lab Immunol 12:436-46. 2005
    ..This suggests that fMLP receptor endocytosis could account, at least in part, for the priming of O2 degrees- production...
  74. ncbi The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8
    Huamei Fu
    Department of Rheumatology and Inflammation Research, University of Goteborg, Goteborg, Sweden
    Immunology 112:201-10. 2004
    ..Here we show that triggering of the formyl peptide receptor (FPR) with f-Met-Leu-Phe (fMLF) substantially reduced the neutrophil superoxide production induced by activation of the ..
  75. ncbi Computational structure-activity relationship analysis of small-molecule agonists for human formyl peptide receptors
    Andrei I Khlebnikov
    Department of Chemistry, Altai State Technical University, Barnaul 656038, Russia
    Eur J Med Chem 45:5406-19. 2010
    ..as therapeutic targets, recent efforts have focused on identification of non-peptide agonists for two FPR subtypes, FPR1 and FPR2...
  76. ncbi Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells
    Nannan Ye
    Department of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China
    Biomed Microdevices 12:513-21. 2010
    The human formyl peptide receptor (FPR) plays an important role in inflammation and immunity. Finding of specific agonists and antagonists of FPR may provide potential therapeutic agents for FPR related disorders...
  77. ncbi Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in THP-1 human monocytes
    Youhong Cui
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Shanghai, 200031, China
    J Nutr 140:377-81. 2010
    ..fMLF is recognized by a human G protein-coupled receptor formyl peptide receptor (FPR) on phagocytic leukocytes. Sesamin at concentrations between 12...
  78. ncbi Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR
    Marie Josephe Rabiet
    CEA Grenoble, Département de Dynamique et Réponse Cellulaires, Laboratoire de Biochimie et de Biophysique des Systèmes Intégrés, UMR 5092 CEA CNRS Université Joseph Fourier, Grenoble, France
    Eur J Immunol 35:2486-95. 2005
    ..In this study, HL-60 cell lines expressing the human N-formyl peptide receptor FPR or its two homologues (FPRL1, FPRL2) were used to determine the receptor selectivity of N-formylated peptides ..
  79. ncbi Characterization of the human fMLP receptor in neutrophils and in Xenopus oocytes
    Sigrid Wittmann
    Department of Anaesthesia, University of Regensburg, 93042 Regensburg, Germany Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF
    Br J Pharmacol 135:1375-82. 2002
    1. N-formyl peptides (e.g. fMLP; N-formyl-L-methionyl-L-leucyl-phenylalanine) are potent mediators for inflammatory reactions...
  80. ncbi X-ray crystallographic and solution state nuclear magnetic resonance spectroscopic investigations of NADP+ binding to ferredoxin NADP reductase from Pseudomonas aeruginosa
    An Wang
    Ralph N Adams Institute for Bioanalytical Chemistry and Department of Chemistry, University of Kansas, Multidisciplinary Research Building, 2030 Becker Drive, Room 220 E, Lawrence, Kansas 66047, USA
    Biochemistry 47:8080-93. 2008
    The ferredoxin nicotinamide adenine dinucleotide phosphate reductase from Pseudomonas aeruginosa ( pa-FPR) in complex with NADP (+) has been characterized by X-ray crystallography and in solution by NMR spectroscopy...
  81. ncbi Molecular cloning of the fMet-Leu-Phe receptor from neutrophils
    K M Thomas
    Department of Physiology, Boston University School of Medicine, Massachusetts 02118
    J Biol Chem 265:20061-4. 1990
    ..In a previous communication we reported the functional reconstitution of the fMLP receptor in Xenopus laevis oocytes (Coats, W. D., and Navarro, J. (1990) J. Biol. Chem. 265, 5964-5966)...
  82. ncbi Glucose-6-phosphate dehydrogenase and ferredoxin-NADP(H) reductase contribute to damage repair during the soxRS response of Escherichia coli
    Mariana Giró
    Instituto de Biologia Molecular y Celular de Rosario IBR, CONICET, División Biología Molecular, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, 2000 Rosario, Argentina
    Microbiology 152:1119-28. 2006
    ..The NADP(H)-dependent enzymes glucose-6-phosphate dehydrogenase (G6PDH) and ferredoxin(flavodoxin)-NADP(H) reductase (FPR), encoded by the zwf and fpr genes, respectively, are committed members of the soxRS regulatory system involved in ..
  83. ncbi Restoration of neutrophil immunocompetence after cardiopulmonary bypass by beta-adrenergic blockers
    Benedikt Trabold
    Department of Anesthesiology, University Medical Center, Regensburg, Germany
    Surgery 147:562-74. 2010
    ..Therefore, we studied the importance of adrenoceptors for the immunomodulation of neutrophils by catecholamines in vitro...
  84. ncbi Formyl peptide receptor expression in birds
    M A Panaro
    Department of Human Anatomy and Histology, University of Bari, Bari, Italy
    Immunopharmacol Immunotoxicol 29:1-16. 2007
    ..The prototypal human fMLP receptor 1 (FPR1) was cloned in 1990 from a differentiated HL-60 myeloid leukemia cell cDNA library...
  85. ncbi Sulfasalazine metabolites and dapsone attenuate formyl-methionyl-leucyl-phenylalanine-induced mucosal injury in rat ileum
    C von Ritter
    Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport
    Gastroenterology 96:811-6. 1989
    ..The distal 10 cm of rat ileum was perfused with formyl-methionyl-leucyl-phenylalanine (FMLP) (10(-5) M), a bacterial peptide that activates and attracts neutrophils...
  86. ncbi Evidence for the presence of N-formyl-methionyl-leucyl-phenylalanine (fMLP) receptor ligands in human amniotic fluid and fMLP receptor modulation by physiological labour
    Carla Biondi
    Department of Biology, University of Ferrara, 44100 Ferrara, Italy
    J Reprod Immunol 68:71-83. 2005
    ..to induce prostaglandin E2 synthesis in the human amnion prompted us to investigate for: (1) the presence of fMLP receptor ligands (fMLPRL) in the amniotic fluid; (2) expression of the fMLP receptor in amniotic tissue; (3) the effect ..
  87. ncbi A novel neutrophil-specific PET imaging agent: cFLFLFK-PEG-64Cu
    Landon W Locke
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA
    J Nucl Med 50:790-7. 2009
    ..of a new, highly potent (64)Cu-labeled peptide, cFLFLFK-PEG-(64)Cu, that targets the formyl peptide receptor (FPR) on leukocytes is described...
  88. ncbi Anaesthetic sensitivity of fMLP-induced cell signalling in Xenopus oocytes
    Sigrid Wittmann
    Department of Anaesthesiology, University of Regensburg, 93042 Regensburg, Germany
    Int Immunopharmacol 6:61-70. 2006
    ..Xenopus oocytes were microinjected with cRNA encoding the fMLP receptor and fMLP-stimulated (100 nM) currents measured, using two-electrode voltage-clamp (-70 mV), before and after ..
  89. ncbi Inhibition by recombinant SLPI and half-SLPI (Asn55-Ala107) of elastase and cathepsin G activities: consequence for neutrophil-platelet cooperation
    P Renesto
    , , Institut Pasteur, Paris, France
    Br J Pharmacol 108:1100-6. 1993
    ..In this experimental system, addition of SLPI or 1/2 SLPI before N-formyl-Met-Leu-Phe (fMLP) led to the inhibition of the resulting platelet activation...
  90. ncbi Type II diabetics with macrovascular complications: polymorphonuclear leukocyte (PMN) filtration, PMN membrane fluidity and cytosolic Ca2+ content after activation
    G Caimi
    Istituto di Clinica Medica e Malattie Cardiovascolari, , Italy
    Horm Metab Res 30:72-6. 1998
    ..PMA (4-phorbol 12-myristate 13-acetate) and fMLP (N-formyl-methionyl-leucyl-phenylalanine) were used as stimulating agents...
  91. ncbi Stereoselective suppression of neutrophil function by ketamine?
    M Weiss
    Department of Anesthesiology, Heinrich Heine Universitat, Dusseldorf, Germany
    Immunopharmacol Immunotoxicol 17:91-107. 1995
    ..and the S(+)-racemate, as well as its drug-free solvent were examined by N-formyl-methionyl-leucyl-phenylalanine-(FMLP)- and zymosan-induced oxygen radical production of polymorphonuclear cells (PMN)...
  92. ncbi A non-peptide receptor inhibitor with selectivity for one of the neutrophil formyl peptide receptors, FPR 1
    Hülya Cevik-Aras
    Department of Rheumatology and Inflammation Research, Institute of Medicine, University of Gothenburg, Box 480, S 405 30 Goteborg, Sweden
    Biochem Pharmacol 83:1655-62. 2012
    The neutrophil formyl peptide receptors (FPR1 and FPR2) are members of the G-protein coupled receptor family. The signals generated by occupied FPRs are both pro-inflammatory and anti-inflammatory...
  93. ncbi Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3
    Christy C Wentworth
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:38448-55. 2011
    ..current study, we expand on these findings and show that commensal bacteria initiate ERK signaling through rapid FPR-dependent reactive oxygen species (ROS) generation and subsequent modulation of MAP kinase phosphatase redox status...
  94. ncbi Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasion
    Katia Bifulco
    Department of Experimental Oncology, National Cancer Institute of Naples, Naples, Italy
    PLoS ONE 7:e44806. 2012
    ..extracellular ligands, and signals in complex with transmembrane receptors such as Formyl-peptide Receptors (FPR)s and integrins...
  95. ncbi Molecular docking of 2-(benzimidazol-2-ylthio)-N-phenylacetamide-derived small-molecule agonists of human formyl peptide receptor 1
    Andrei I Khlebnikov
    Department of Chemistry, Altai State Technical University, Barnaul, Russia
    J Mol Model 18:2831-43. 2012
    Human N-formyl peptide receptor 1 (FPR1) is a G protein-coupled receptor (GPCR) involved in host defense and sensing cellular damage...
  96. ncbi The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells
    Erich H Schneider
    Molecular Signaling Section, Laboratory of Molecular Immunology, NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 287:40779-92. 2012
    Lens degeneration in Fpr1(-/-) mice prompted us to search for functional FPR1 expression directly on lens epithelial cells.
  97. ncbi 5-Hydroxy-7-methoxyflavone inhibits N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils
    Hsiang Ruei Liao
    Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Tao Yuan, Taiwan
    Biochem Pharmacol 84:182-91. 2012
    ..Tiliaceae), on N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced respiratory burst and cathepsin G release in human neutrophils...
  98. ncbi The major leukocyte chemotactic and activating factors in the mouse gut lumen are not N-formylpeptide receptor 1 agonists
    Teresa Ojode
    Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Innate Immun 5:2-14. 2013
    ..N-formylpeptides, which are potent chemoattractants for phagocytic leukocytes acting at G-protein-coupled receptors FPR1 and FPR2...
  99. ncbi Failure of neutrophil chemotactic function in breast cancer patients treated with chemotherapy
    Maria Angélica O Mendonça
    Department of Biological Sciences, Faculty of Medicine of Triangulo Mineiro, Praça Manoel Terra, 330, CEP, 38015 050, Uberaba MG, Brazil
    Cancer Chemother Pharmacol 57:663-70. 2006
    ..the in vitro migratory responses towards the chemotactic stimuli N-formyl- L-methionyl- L-leucyl- L-phenylalanine (fMLP), leukotriene B(4) (LTB(4)) and interleukin (IL)-8 were observed in purified neutrophils from controls and patients,..
  100. ncbi Splitomicin inhibits fMLP-induced superoxide anion production in human neutrophils by activate cAMP/PKA signaling inhibition of ERK pathway
    Fu Chao Liu
    Department of Anesthesiology, Chang Gung Memorial Hospital, Linkou, Taiwan, ROC
    Eur J Pharmacol 688:68-75. 2012
    ..Neutrophils were prepared following standard procedures. Neutrophils induced by either fMLP (1 μM) or PMA (100 nM) were observed using a flow cytometer and the intracellular production of superoxide anions ..
  101. ncbi Optimisation of baseline genotypic testing for safe and efficient maraviroc administration
    S Sierra
    University of Cologne, Institute of Virology, Cologne, Germany
    J Int AIDS Soc 15:18134. 2012
    Different diagnostic parameters may affect the tropism prediction reliability. The impact of usage of FPR cut-offs<20%, use of viral RNA versus proviral DNA samples, single versus triple amplification, and presence of MVC resistance ..

Research Grants88

  1. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Gerardo Hernandez; Fiscal Year: 2004
    ..of these experiments is to study the effects of bacterial peptides such as N-formylmethionyl-leucyl-phenylalanine (FMLP) in a reactivated model of colitis...
  2. Effects of Formyl Peptide Receptor variants on function
    John Mills; Fiscal Year: 2005
    ..neutrophils demonstrated poor chemotactic response toward the formyl peptide, methionine-leucine-phenylalanine (fMLP)...
  3. Molecular Mechanism of Leukocyte Activation
    Richard Ye; Fiscal Year: 2007
    ..There are 4 specific aims. In Aim 1, we will determine the role of PKCdelta in formyl peptide receptor (FPR)-mediated O2- generation...
  4. Structure-Function Studies of Annexin I and II
    Hartmut Luecke; Fiscal Year: 2006
    ..A peptide of the N-terminal domain of annexin I activates the formyl peptide receptor (FPR) on human neutrophils...
  5. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2006
    ..However, once neutrophils are activated by fMLP, a bacterial chemoattractant peptide, CD32A is converted to a functionally active state and can bind ligand ..
  6. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2003
    ..However, once neutrophils are activated by fMLP, a bacterial chemoattractant peptide, CD32A is converted to a functionally active state and can bind ligand ..
  7. Regulation of CD32A in neutrophils
    Periasamy Selvaraj; Fiscal Year: 2007
    ..However, once neutrophils are activated by fMLP, a bacterial chemoattractant peptide, CD32A is converted to a functionally active state and can bind ligand ..
  8. Membrane Organization in Cell Signaling and Adhesion
    Tione Buranda; Fiscal Year: 2007
    ..Chemokine/chemoattractant GPCRs, such as the N-Formyl peptide receptor (FPR), regulate numerous aspects of leukocyte function, including controlling hematopoiesis, chemotaxis and activation ..
  9. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    Julian Gomez Cambronero; Fiscal Year: 2009
    ..The goal is to test the sequential model: (a) upon FMLP or IL-8 stimulation of neutrophils, tyrosine kinases Syk/Src phosphorylate PLD2; (b) Grb2 binds to PLD2 through its ..
  10. Mechanism of PLD interaction with kinases and Rac: Role on phagocyte chemotaxis
    JULIAN GOMEZ CAMBRONERO; Fiscal Year: 2010
    ..The goal is to test the sequential model: (a) upon FMLP or IL-8 stimulation of neutrophils, tyrosine kinases Syk/Src phosphorylate PLD2;(b) Grb2 binds to PLD2 through its ..
  11. MOLECULAR MECHANISMS OF LEUKOCYTE ACTIVATION
    Richard Ye; Fiscal Year: 2002
    This is a study on the N-formyl peptide receptor (FPR), a leukocyte chemoattractant receptor that recognizes a bacterially derived agonist...
  12. HUMORAL AND CELLULAR MEDIATORS OF INFLAMMATION
    Ralph Snyderman; Fiscal Year: 1993
    ..g. fMLP) and the lipid chemoattractants, leukotriene B4 (LTB4) and platelet activating factor (PAF)...
  13. MOLECULAR ASPECTS OF PMN FUNCTION IN DENTAL DISEASE
    Ernesto DeNardin; Fiscal Year: 2000
    ..Previous studies from our group and others suggest a molecular alteration of the FMLP receptor as well as alterations in transmembrane signaling transmission mechanisms common to different chemoattractants...
  14. MOLECULAR ASPECTS OF PMN FUNCTION IN DENTAL DISEASE
    Ernesto DeNardin; Fiscal Year: 1993
    ..The FMLP receptor is of great biological significance since it plays a crucial role in neutrophil response and motility...
  15. MOLECULAR ASPECTS OF PMN FUNCTION IN DENTAL DISEASE
    Ernesto DeNardin; Fiscal Year: 2005
    ..3) identify and characterize residues and domains of the FMLP receptor involved in transmembrane signaling...
  16. REGULATION OF HUMAN PHAGOCYTE FUNCTION BY RAC PROTEINS
    Ulla Knaus; Fiscal Year: 2006
    ..Our studies so far point to a role of Pak in several aspects of the fMLP-induced respiratory burst including multiple phosphorylation events and association with cytochrome b558...
  17. Mechanisms of chemoattractant receptor regulation
    HEINI MIETTINEN; Fiscal Year: 2005
    ..In the hierarchy of receptor cross-desensitization, the formyl peptide receptor (FPR) is the dominant receptor, i.e...
  18. MECHANISMS OF LEUKOCYTE ACTIVATION AND CHEMOTAXIS
    Eric Prossnitz; Fiscal Year: 2002
    ..The specific aims of this proposal include the determination of the role of the N-formyl peptide receptor (FPR) activation I the physical binding of the receptor to G protein...
  19. Caveolin-1 and NO Regulate PMN-mediated Increases in Vascular Permeability
    Richard Minshall; Fiscal Year: 2009
    ..The studies will test the hypotheses that (i) fMLP activation of PMNs stimulates caveolae- mediated albumin transcytosis in endothelial cells and mediates the ..