FOXQ1

Summary

Gene Symbol: FOXQ1
Description: forkhead box Q1
Alias: HFH1, forkhead box protein Q1, HFH-1, HNF-3/forkhead-like protein 1, hepatocyte nuclear factor 3 forkhead homolog 1, winged helix/forkhead transcription factor
Species: human
Products:     FOXQ1

Top Publications

  1. Bieller A, Pasche B, Frank S, Glaser B, Kunz J, Witt K, et al. Isolation and characterization of the human forkhead gene FOXQ1. DNA Cell Biol. 2001;20:555-61 pubmed
    ..The 2.7-kb transcript of the human FOXQ1 gene is expressed predominantly in the stomach, trachea, bladder and salivary gland...
  2. Hong H, Noveroske J, Headon D, Liu T, Sy M, Justice M, et al. The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice. Genesis. 2001;29:163-71 pubmed
    ..We demonstrate that the winged helix/forkhead transcription factor, Foxq1 (Forkhead box, subclass q, member 1) is mutant in sa mice...
  3. Xia L, Huang W, Tian D, Zhang L, Qi X, Chen Z, et al. Forkhead box Q1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression. Hepatology. 2014;59:958-73 pubmed publisher
    Forkhead box Q1 (FoxQ1) is a master regulator of tumor metastasis. However, the molecular mechanism of FoxQ1 in regulating hepatocellular carcinoma (HCC) metastasis remains unknown...
  4. Kaneda H, Arao T, Tanaka K, Tamura D, Aomatsu K, Kudo K, et al. FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth. Cancer Res. 2010;70:2053-63 pubmed publisher
    Forkhead box Q1 (FOXQ1) is a member of the forkhead transcription factor family, and it has recently been proposed to participate in gastric acid secretion and mucin gene expression in mice...
  5. Wang W, He S, Ji J, Huang J, Zhang S, Zhang Y. The prognostic significance of FOXQ1 oncogene overexpression in human hepatocellular carcinoma. Pathol Res Pract. 2013;209:353-8 pubmed publisher
    b>FOXQ1 (forkhead box Q1) is a forkhead transcription factor, and FOX genes play significant roles in a series of biological processes. The aim of our study was to verify the importance of FOXQ1 as a prognostic indicator in HCC patients...
  6. Liang S, Yan X, Wang B, Jin H, Yao L, Li Y, et al. Increased expression of FOXQ1 is a prognostic marker for patients with gastric cancer. Tumour Biol. 2013;34:2605-9 pubmed publisher
    Altered expression of forkhead box Q1 (FOXQ1) is observed in various types of human cancers. However, the clinical significance of FOXQ1 expression in gastric cancer (GC) remains largely unknown...
  7. Sun H, Cheng S, Tu Y, Li X, Zhang S. FoxQ1 promotes glioma cells proliferation and migration by regulating NRXN3 expression. PLoS ONE. 2013;8:e55693 pubmed publisher
    Forkhead box Q1 (FoxQ1) is a member of the forkhead transcription factor family, and it has recently been found to participate in cancer development...
  8. Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, et al. Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. Cancer Res. 2011;71:1292-301 pubmed publisher
    ..a novel function in metastasis that was not previously known for the transcription factor Forkhead Box Q1 (Foxq1)...
  9. Qiao Y, Jiang X, Lee S, Karuturi R, Hooi S, Yu Q. FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res. 2011;71:3076-86 pubmed publisher
    ..In this study, we defined a critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells...

More Information

Publications74

  1. Christensen J, Bentz S, Sengstag T, Shastri V, Anderle P. FOXQ1, a novel target of the Wnt pathway and a new marker for activation of Wnt signaling in solid tumors. PLoS ONE. 2013;8:e60051 pubmed publisher
    The forkhead box transcription factor FOXQ1 has been shown to be upregulated in colorectal cancer (CRC) and metastatic breast cancer and involved in tumor development, epithelial-mesenchymal transition and chemoresistance...
  2. Cui Z, Zhao Y. microRNA-342-3p targets FOXQ1 to suppress the aggressive phenotype of nasopharyngeal carcinoma cells. BMC Cancer. 2019;19:104 pubmed publisher
    ..Mechanistically, FOXQ1 served as a functional target of miR-342-3p...
  3. Hoggatt A, Kim J, Ustiyan V, Ren X, Kalin T, Kalinichenko V, et al. The transcription factor Foxf1 binds to serum response factor and myocardin to regulate gene transcription in visceral smooth muscle cells. J Biol Chem. 2013;288:28477-87 pubmed publisher
    ..Unlike Foxo4 and Foxq1, which bind to MRTFs and block their interaction with SRF, Foxf1 acts synergistically with these proteins to ..
  4. Topczewska J, Shoela R, Tomaszewski J, Mirmira R, Gosain A. The Morphogenesis of Cranial Sutures in Zebrafish. PLoS ONE. 2016;11:e0165775 pubmed publisher
    ..we show RNA in situ hybridization for col1a1a, col2a1a, col10a1, bglap/osteocalcin, fgfr1a, fgfr1b, fgfr2, fgfr3, foxq1, twist2, twist3, runx2a, runx2b, sp7/osterix, and spp1/ osteopontin, indicating that the expression of genes ..
  5. Ross J, Huh D, Noble L, Tavazoie S. Identification of molecular determinants of primary and metastatic tumour re-initiation in breast cancer. Nat Cell Biol. 2015;17:651-64 pubmed publisher
    ..Tumorigenic-enriched subpopulations exhibited increased expression of LAMA4, FOXQ1 and NAP1L3—genes that are also expressed at greater levels by independently derived metastatic ..
  6. Gratchev A, Ovsiy I, Manousaridis I, Riabov V, Orekhov A, Kzhyshkowska J. Novel monocyte biomarkers of atherogenic conditions. Curr Pharm Des. 2013;19:5859-64 pubmed
    ..These include stabilin-1, FOXQ1 and IL17RB...
  7. Gambini V, Tilio M, Maina E, Andreani C, Bartolacci C, Wang J, et al. In vitro and in vivo studies of gold(I) azolate/phosphane complexes for the treatment of basal like breast cancer. Eur J Med Chem. 2018;155:418-427 pubmed publisher
    ..were evaluated in vitro by MTT tests in human MDA-MB-231, human mammary epithelial HMLE cells overexpressing FoxQ1, and murine A17?cells as models of BLBC...
  8. Fortin J, Ongaro L, Li Y, Tran S, Lamba P, Wang Y, et al. Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?. Mol Endocrinol. 2015;29:963-77 pubmed publisher
    ..Gnrhr expression, in contrast, appears to be FOXL2, SMAD4, and, perhaps, activin independent in vivo. ..
  9. Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, et al. Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. Cell Tissue Res. 2018;373:379-393 pubmed publisher
    ..In our previous study, we found that FOXQ1 binds directly to the SIRT1 promoter to regulate cellular senescence and also promotes cell proliferation and ..
  10. Cui Y, Qiao A, Jiao T, Zhang H, Xue Y, Zou Y, et al. The hepatic FOXQ1 transcription factor regulates glucose metabolism in mice. Diabetologia. 2016;59:2229-39 pubmed publisher
    Hepatic forkhead box q1 (FOXQ1) expression levels are regulated by nutritional and pathophysiological status. In this study we investigated the role of FOXQ1 in the regulation of hepatic gluconeogenesis...
  11. Yeo H, Ting S, Brena R, Koh G, Chen A, Toh S, et al. Genome-Wide Transcriptome and Binding Sites Analyses Identify Early FOX Expressions for Enhancing Cardiomyogenesis Efficiency of hESC Cultures. Sci Rep. 2016;6:31068 pubmed publisher
    ..We hypothesized that the parental expressions of FOXC1, FOXD1 and FOXQ1 transcription factors (TFs) are correlative with eventual cardiomyogenic outcome...
  12. Bagati A, Bianchi Smiraglia A, Moparthy S, Kolesnikova K, Fink E, Kolesnikova M, et al. FOXQ1 controls the induced differentiation of melanocytic cells. Cell Death Differ. 2018;25:1040-1049 pubmed publisher
    Oncogenic transcription factor FOXQ1 has been implicated in promotion of multiple transformed phenotypes in carcinoma cells...
  13. Bettin A, Reyes I, Reyes N. Gene expression profiling of prostate cancer-associated genes identifies fibromodulin as potential novel biomarker for prostate cancer. Int J Biol Markers. 2016;31:e153-62 pubmed publisher
    ..evaluated were ESM-1, SERPINE2, CLU, BGN, A2M, PENK, FMOD, CD81, DCN, TSPAN8, KBTBD10, F2RL1, TMSB4X, SNCG, CXXC5, FOXQ1, PDPN, SPN, CAV1, CD24 and KLK3...
  14. Fleger Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen Z, et al. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol. 2016;56:42-56 pubmed publisher
    ..This is due to reduced expression of transcription factors such as HoxC13, FoxN1, FoxQ1 and Msx2, known to regulate expression of hair keratins...
  15. Hardy K, Wu F, Tu W, Zafar A, Boulding T, McCuaig R, et al. Identification of chromatin accessibility domains in human breast cancer stem cells. Nucleus. 2016;7:50-67 pubmed publisher
    ..Silencing of 2 members of the FOX family, FOXN2 and FOXQ1, repressed CSCs and the mesenchymal phenotype and inhibited the CSC gene signature...
  16. Chiang K, Zielinska A, Shaaban A, Sanchez Bailon M, Jarrold J, Clarke T, et al. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. Cell Rep. 2017;21:3498-3513 pubmed publisher
    ..Together, our findings highlight the importance of PRMT5 in BCSC maintenance and suggest that small-molecule inhibitors of PRMT5 or downstream targets could be an effective strategy eliminating this cancer-causing population. ..
  17. Rogers R, Slatkin M. Excess of genomic defects in a woolly mammoth on Wrangel island. PLoS Genet. 2017;13:e1006601 pubmed publisher
    ..Finally, at the locus of FOXQ1 we observe two independent loss-of-function mutations, which would confer a satin coat phenotype in this island ..
  18. Godoy P, Schmidt Heck W, Natarajan K, Lucendo Villarin B, Szkolnicka D, Asplund A, et al. Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells. J Hepatol. 2015;63:934-42 pubmed publisher
    ..Key TF of two of these clusters include SOX11, FOXQ1, and YBX3...
  19. Walters K, Olsufka R, Kuestner R, Wu X, Wang K, Skerrett S, et al. Prior infection with Type A Francisella tularensis antagonizes the pulmonary transcriptional response to an aerosolized Toll-like receptor 4 agonist. BMC Genomics. 2015;16:874 pubmed publisher
    ..multiple members of the forkhead transcription factor family (FoxA1, Foxa2, FoxD1, Foxd3, Foxf2, FoxI1, Fox03, Foxq1), IRF1, CEBPA, and Mef2...
  20. Huang W, Chen Z, Shang X, Tian D, Wang D, Wu K, et al. Sox12, a direct target of FoxQ1, promotes hepatocellular carcinoma metastasis through up-regulating Twist1 and FGFBP1. Hepatology. 2015;61:1920-33 pubmed publisher
    ..Furthermore, forkhead box Q1 (FoxQ1) directly bound to the Sox12 promoter and transactivated its expression, which contributed to Sox12 overexpression ..
  21. Earley A, Dixon C, Shiau C. Genetic analysis of zebrafish homologs of human FOXQ1, foxq1a and foxq1b, in innate immune cell development and bacterial host response. PLoS ONE. 2018;13:e0194207 pubmed publisher
    b>FOXQ1 is a member of the forkhead-box transcription factor family that has important functions in development, cancer, aging, and many cellular processes...
  22. Samatar A, Wang L, Mirza A, Koseoglu S, Liu S, Kumar C. Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor. J Biol Chem. 2002;277:28118-26 pubmed
    ..These results suggest that repression of TGF-beta 2 promoter activity in cells expressing activated Akt may play a role in promoting tumorigenesis and escape from the growth-inhibitory and/or apoptotic effects of TGF-beta. ..
  23. Kim S, Kaschula C, Priedigkeit N, Lee A, Singh S. Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide. J Biol Chem. 2016;291:13495-508 pubmed publisher
    ..DATS-mediated inhibition of bCSC was associated with a decrease in the protein level of FoxQ1. Overexpression of FoxQ1 in MCF-7 and SUM159 cells increased ALDH1 activity and the CD49f(+)/CD24(-) fraction...
  24. Peng X, Luo Z, Kang Q, Deng D, Wang Q, Peng H, et al. FOXQ1 mediates the crosstalk between TGF-β and Wnt signaling pathways in the progression of colorectal cancer. Cancer Biol Ther. 2015;16:1099-109 pubmed publisher
    A wide variety of signaling transduction pathways contribute to tumorigenesis. Forkhead box Q1 (FOXQ1) is a member of the forkhead transcription factor family and its upregulation is closely correlated with tumor progression and ..
  25. Gao M, Shih I, Wang T. The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas. Int J Mol Sci. 2012;13:13881-93 pubmed publisher
    The role of the forkhead box Q1 (FOXQ1) transcription factor in cancer pathogenesis has recently emerged...
  26. Feng A, Yuan X, Li X. MicroRNA-345 inhibits metastasis and epithelial-mesenchymal transition of gastric cancer by targeting FOXQ1. Oncol Rep. 2017;38:2752-2760 pubmed publisher
    ..Furthermore, FOXQ1 was confirmed to be the downstream target of miR-345 in GC cells...
  27. Zhang Z, Ma J, Luan G, Kang L, Su Y, He Y, et al. MiR-506 suppresses tumor proliferation and invasion by targeting FOXQ1 in nasopharyngeal carcinoma. PLoS ONE. 2015;10:e0122851 pubmed publisher
    ..Moreover, we identified the Forkhead box Q1 (FOXQ1) gene as a novel direct target of miR-506...
  28. Pei Y, Wang P, Liu H, He F, Ming L. FOXQ1 promotes esophageal cancer proliferation and metastasis by negatively modulating CDH1. Biomed Pharmacother. 2015;74:89-94 pubmed publisher
    ..Foxhead box Q1 (FOXQ1), which has a major impact on several kinds of tumor forming and metastasis, while whether it triggers ESCC ..
  29. Luo Q, Wang C, Yang L, Gao X, Sun H, Zhang Y, et al. FOXQ1/NDRG1 axis exacerbates hepatocellular carcinoma initiation via enhancing crosstalk between fibroblasts and tumor cells. Cancer Lett. 2018;417:21-34 pubmed publisher
    ..In the present study, we reveal that CAFs induce forkhead box Q1 (FOXQ1) expression, and N-myc downstream-regulated gene 1 (NDRG1) is therefore trans-activated to enhance HCC initiation...
  30. Zhu Z, Zhu Z, Pang Z, Xing Y, Wan F, Lan D, et al. Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer. Int J Oncol. 2013;42:1271-8 pubmed publisher
    ..In this study, we defined a pivotal functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in bladder cancer...
  31. Liu P, Chen L. Inhibition of sonic hedgehog signaling blocks cell migration and growth but induces apoptosis via suppression of FOXQ1 in natural killer/T-cell lymphoma. Leuk Res. 2018;64:1-9 pubmed publisher
    The present study explored the effects of Forkhead box Q1 (FOXQ1) on cell proliferation, cell cycle and apoptosis via the Sonic hedgehog (Shh) pathway in Natural killer/T-cell lymphoma (NKTCL)...
  32. Qin J, Xu Y, Li X, Wu Y, Zhou J, Wang G, et al. Effects of lentiviral-mediated Foxp1 and Foxq1 RNAi on the hepatocarcinoma cell. Exp Mol Pathol. 2014;96:1-8 pubmed publisher
    Foxp1 and Foxq1 are two multifunctional molecules of "forkhead box (Fox)" family...
  33. Zhan H, Xu J, Wang L, Wu D, Zhang G, Hu S. FoxQ1 is a Novel Molecular Target for Pancreatic Cancer and is Associated with Poor Prognosis. Curr Mol Med. 2015;15:469-77 pubmed
    b>FOXQ1 is an oncogene for a variety of tumors and encodes the forkhead boxrelated transcription factor FoxQ1. However, little is known about the role of FoxQ1 in pancreatic cancer (PC)...
  34. Zhang J, Liu Y, Zhang J, Cui X, Li G, Wang J, et al. FOXQ1 promotes gastric cancer metastasis through upregulation of Snail. Oncol Rep. 2016;35:3607-13 pubmed publisher
    ..Forkhead box Q1 (FOXQ1) is a member of the forkhead transcription factor family and its upregulation is closely correlated with tumor ..
  35. Ma X, Liu L, Meng J. MicroRNA-125b promotes neurons cell apoptosis and Tau phosphorylation in Alzheimer's disease. Neurosci Lett. 2017;661:57-62 pubmed publisher
    ..Forkhead box Q1 (FOXQ1) was the direct target gene of miR-125b, which involved in the effects of miR-125b on neurons cell apoptosis and ..
  36. Peng X, Huang H, Lu J, Liu X, Zhao F, Zhang B, et al. MiR-124 suppresses tumor growth and metastasis by targeting Foxq1 in nasopharyngeal carcinoma. Mol Cancer. 2014;13:186 pubmed publisher
    ..Homo sapiens forkhead box Q1 (Foxq1) was confirmed as a novel direct target gene of miR-124 by the dual-luciferase assay and western bolt...
  37. Weng W, Okugawa Y, Toden S, Toiyama Y, Kusunoki M, Goel A. FOXM1 and FOXQ1 Are Promising Prognostic Biomarkers and Novel Targets of Tumor-Suppressive miR-342 in Human Colorectal Cancer. Clin Cancer Res. 2016;22:4947-4957 pubmed
    ..and comprehensive discovery step by evaluating the expression of FOX family members, and identified that FOXM1 and FOXQ1 are frequently overexpressed in colorectal cancer...
  38. Li Y, Zhang Y, Yao Z, Li S, Yin Z, Xu M. Forkhead box Q1: A key player in the pathogenesis of tumors (Review). Int J Oncol. 2016;49:51-8 pubmed publisher
    As a member of the Forkhead box protein family, Forkhead box Q1 (FOXQ1) is a transcription factor that functions to regulate cell differentiation...
  39. Fan D, Feng X, Qi P, Chen Y. Forkhead factor FOXQ1 promotes TGF-β1 expression and induces epithelial-mesenchymal transition. Mol Cell Biochem. 2014;397:179-86 pubmed publisher
    ..have discovered a new transfer function, which is not previously known about transcription factor forkhead box Q1 (FOXQ1). The shRNA anti-FOXQ1 gene was synthesized and transfected into the Hela and EpRas cells...
  40. Edwards D, Gilbert J, Hicks J, Myers J, Jiang L, Cummings A, et al. Linkage and association of successful aging to the 6q25 region in large Amish kindreds. Age (Dordr). 2013;35:1467-77 pubmed publisher
    ..89?×?10(-6)). These findings suggest potentially novel genes in the 6q25-q27 region linked and associated with SA in the Amish; however, these findings should be verified in an independent replication cohort. ..
  41. Feng J, Xu L, Ni S, Gu J, Zhu H, Wang H, et al. Involvement of FoxQ1 in NSCLC through regulating EMT and increasing chemosensitivity. Oncotarget. 2014;5:9689-702 pubmed
    Forkhead box Q1 (FoxQ1) is a member of the forkhead transcription factor family...
  42. Xiang X, Deng J, Liu Y, Wan L, Feng M, Chen J, et al. MiR-1271 Inhibits Cell Proliferation, Invasion and EMT in Gastric Cancer by Targeting FOXQ1. Cell Physiol Biochem. 2015;36:1382-94 pubmed
    b>FOXQ1 overexpression has been reported to enhance tumor growth and invasion. However, the biological function of FOXQ1 and the mechanism underlying its upregulation in gastric cancer (GC) remain unknown...
  43. Bao B, Azmi A, Aboukameel A, Ahmad A, Bolling Fischer A, Sethi S, et al. Pancreatic cancer stem-like cells display aggressive behavior mediated via activation of FoxQ1. J Biol Chem. 2014;289:14520-33 pubmed publisher
    ..showed that CSLCs (CD44(+)/CD133(+)/EpCAM(+)) exhibit differential expression of more than 1,600 mRNAs, including FoxQ1, compared with the triple-marker-negative (CD44(-)/CD133(-)/EpCAM(-)) cells...
  44. Qin A, Zhu J, Liu X, Zeng D, Gu M, Lv C. MicroRNA-1271 inhibits cellular proliferation of hepatocellular carcinoma. Oncol Lett. 2017;14:6783-6788 pubmed publisher
    ..Forkhead box Q1 (FOXQ1) was targeted by miR-1271...
  45. Hupe M, Li M, Kneitz S, Davydova D, Yokota C, Kele J, et al. Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels. Sci Signal. 2017;10: pubmed publisher
    ..We identified genes encoding brain endothelium-specific transcription factors (Foxf2, Foxl2, Foxq1, Lef1, Ppard, Zfp551, and Zic3) that are associated with maturation of the blood-..
  46. Guo J, Yan Y, Yan Y, Guo Q, Zhang M, Zhang J, et al. Tumor-associated macrophages induce the expression of FOXQ1 to promote epithelial-mesenchymal transition and metastasis in gastric cancer cells. Oncol Rep. 2017;38:2003-2010 pubmed publisher
    ..The expression of EMT-related genes and forkhead box Q1 (FOXQ1) were examined in MKN45 and MKN74 cells after being co-cultured with TAMs...
  47. CANDELARIO J, Chen L, Marjoram P, Reddy S, Comai L. A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 2012;4:567-77 pubmed
    ..Through this analysis we identified the gene encoding for the transcription factor FOXQ1, as a gene whose expression is induced in both cells expressing progerin and elevated levels of wild-type prelamin ..
  48. Vishnubalaji R, Hamam R, Yue S, Al Obeed O, Kassem M, Liu F, et al. MicroRNA-320 suppresses colorectal cancer by targeting SOX4, FOXM1, and FOXQ1. Oncotarget. 2016;7:35789-35802 pubmed publisher
    ..Using a series of biochemical assays and functional validation, SOX4, FOXM1, and FOXQ1 were validated as novel gene targets for the miR-320 family...
  49. Tu S, Zheng J, Gao X, Guan C, Cai B, Xiang L. The role of Foxq1 in proliferation of human dental pulp stem cell. Biochem Biophys Res Commun. 2018;497:543-549 pubmed publisher
    This study aimed to investigate the role for Foxq1 in proliferation activity regulation of dental pulp stem cells (DPSCs). Proliferation of DPSC was induced by calcium hydroxide, then expression alteration of Foxq1 was evaluated...
  50. Zhang X, Wang L, Wang Y, Shi S, Zhu H, Xiao F, et al. Inhibition of FOXQ1 induces apoptosis and suppresses proliferation in prostate cancer cells by controlling BCL11A/MDM2 expression. Oncol Rep. 2016;36:2349-56 pubmed publisher
    Forkhead box Q1 (FOXQ1) has been recognized as an oncogene that is overexpressed in different cancers, and several studies have shown that FOXQ1 is related to apoptosis and proliferation in many cancer types...
  51. Meng F, Speyer C, Zhang B, Zhao Y, Chen W, Gorski D, et al. PDGFRα and β play critical roles in mediating Foxq1-driven breast cancer stemness and chemoresistance. Cancer Res. 2015;75:584-93 pubmed publisher
    ..However, the underlying mechanisms mediating these processes are unclear. Here, we report that Foxq1, a forkhead box-containing transcription factor and EMT-inducing gene, promotes stemness traits and ..
  52. Ovsiy I, Riabov V, Manousaridis I, Michel J, Moganti K, Yin S, et al. IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration. Sci Rep. 2017;7:16847 pubmed publisher
    ..the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages...
  53. Xiao B, Liu H, Gu Z, Ji C. Expression of microRNA-133 inhibits epithelial-mesenchymal transition in lung cancer cells by directly targeting FOXQ1. Arch Bronconeumol. 2016;52:505-11 pubmed publisher
    ..We have identified miR-133 as a putative regulator of FOXQ1 expression, and investigated the potential involvement of miR-133 in the migration and invasion of lung cancer ..
  54. Akutekwe A, Seker H. A hybrid dynamic Bayesian network approach for modelling temporal associations of gene expressions for hypertension diagnosis. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:804-7 pubmed publisher
    ..Results show that cell regulation FOXQ1 may inhibit the expression of focusyltransferase-6 (FUT6) and that ABCG1 ATP-binding cassette sub-family G may ..
  55. Leblanc M, Kulle B, Sundet K, Agartz I, Melle I, Djurovic S, et al. Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function. J Psychiatr Res. 2012;46:271-8 pubmed publisher
    ..32×10(-8)). A highly significant epistatic interaction was found between rs9378605 upstream of FOXQ1 and rs11699311 downstream of SUMO1P1 for the Grooved Pegboard test (p=7.6×10(-14))...
  56. Zhang J, Yang Y, Yang T, Yuan S, Wang R, Pan Z, et al. Double-negative feedback loop between microRNA-422a and forkhead box (FOX)G1/Q1/E1 regulates hepatocellular carcinoma tumor growth and metastasis. Hepatology. 2015;61:561-73 pubmed publisher
    ..A mechanistic study identified three genes, forkhead box G1 (FOXG1), FOXQ1, and FOXE1, as miR-422a targets in the regulation of HCC development...
  57. Zhang M, Xu Q, Yan S, Li Z, Yan W, Jia X. Suppression of forkhead box Q1 by microRNA-506 represses the proliferation and epithelial-mesenchymal transition of cervical cancer cells. Oncol Rep. 2016;35:3106-14 pubmed publisher
    ..Forkhead box Q1 (FOXQ1) functions as an oncogene in various cancer types...
  58. Wang P, Lv C, Zhang T, Liu J, Yang J, Guan F, et al. FOXQ1 regulates senescence-associated inflammation via activation of SIRT1 expression. Cell Death Dis. 2017;8:e2946 pubmed publisher
    ..Here, we demonstrated that the protein level of forkhead box Q1 (FOXQ1), which highly overexpresses in several kinds of tumors, was significantly downregulated during both replicative ..
  59. Yonemori K, Seki N, Idichi T, Kurahara H, Osako Y, Koshizuka K, et al. The microRNA expression signature of pancreatic ductal adenocarcinoma by RNA sequencing: anti-tumour functions of the microRNA-216 cluster. Oncotarget. 2017;8:70097-70115 pubmed publisher
    ..Forkhead box Q1 (FOXQ1) was directly regulated by miR-216b-3p and overexpression of FOXQ1 was confirmed in clinical ..
  60. Bagati A, Bianchi Smiraglia A, Moparthy S, Kolesnikova K, Fink E, Lipchick B, et al. Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1. Cell Rep. 2017;20:2820-2832 pubmed publisher
    ..We find that levels of the FOXQ1 transcription factor, an oncogene in carcinomas, are decreased during melanoma progression...
  61. Abba M, Patil N, Rasheed K, Nelson L, Mudduluru G, Leupold J, et al. Unraveling the role of FOXQ1 in colorectal cancer metastasis. Mol Cancer Res. 2013;11:1017-28 pubmed publisher
    ..This study demonstrates that the winged helix transcription factor, FOXQ1, contributes to this rewiring process, in part by directly modulating the transcription of TWIST1, itself a key ..
  62. Low S, Kuchiba A, Zembutsu H, Saito A, Takahashi A, Kubo M, et al. Genome-wide association study of pancreatic cancer in Japanese population. PLoS ONE. 2010;5:e11824 pubmed publisher
    ..3, 12p11.21 and 7q36.2, respectively. These associated SNPs are located within linkage disequilibrium blocks containing genes that have been implicated some roles in the oncogenesis of pancreatic cancer. ..
  63. Bodelon C, Oh H, Chatterjee N, Garcia Closas M, Palakal M, Sherman M, et al. Association between breast cancer genetic susceptibility variants and terminal duct lobular unit involution of the breast. Int J Cancer. 2017;140:825-832 pubmed publisher
    ..Six of the 62 SNPs (9.7%) were nominally associated with at least one TDLU measure: rs616488 (PEX14), rs11242675 (FOXQ1) and rs6001930 (MKL1) were associated with higher TDLU count (p?=?0.047, 0.045 and 0...
  64. Gao M, Wu R, Herlinger A, Yap K, Kim J, Wang T, et al. Identification of the NAC1-regulated genes in ovarian cancer. Am J Pathol. 2014;184:133-40 pubmed publisher
    ..Among NAC1-regulated genes, FOXQ1 was further characterized because it is involved in cell motility and epithelial-mesenchymal transition...
  65. Leger B, Senese R, Al Khodairy A, Deriaz O, Gobelet C, Giacobino J, et al. Atrogin-1, MuRF1, and FoXO, as well as phosphorylated GSK-3beta and 4E-BP1 are reduced in skeletal muscle of chronic spinal cord-injured patients. Muscle Nerve. 2009;40:69-78 pubmed publisher
    ..The downregulation of signaling proteins that regulate anabolism, such as IGF, GSK-3beta, and 4E-BP1, would reduce the ability to increase protein synthesis rates. ..