FOXP3

Summary

Gene Symbol: FOXP3
Description: forkhead box P3
Alias: AIID, DIETER, IPEX, JM2, PIDX, XPID, FOXP3delta7, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin
Species: human

Top Publications

  1. ncbi FOXP3 controls regulatory T cell function through cooperation with NFAT
    Yongqing Wu
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 126:375-87. 2006
  2. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
  3. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
  4. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
  5. pmc Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer
    Mia Kim
    Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 8:e53630. 2013
  6. ncbi Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:129-38. 2007
  7. doi FOXP3 expression and overall survival in breast cancer
    Andrea Merlo
    Molecular Biology Unit, Department of Experimental Oncology, Pathology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori and the Institute of Pathology, University of Milan, Milan, Italy
    J Clin Oncol 27:1746-52. 2009
  8. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
  9. pmc FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    Tao Zuo
    Program in Molecular, Cellular, and Developmental Biology and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Cell 129:1275-86. 2007
  10. ncbi Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis
    Valerie Guyot-Revol
    Tuberculosis Immunology Group, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 7, Oxford OX3 9DU, UK
    Am J Respir Crit Care Med 173:803-10. 2006

Detail Information

Publications261 found, 100 shown here

  1. ncbi FOXP3 controls regulatory T cell function through cooperation with NFAT
    Yongqing Wu
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 126:375-87. 2006
    ..Treg) function is mediated by an analogous cooperative complex of NFAT with the forkhead transcription factor FOXP3, a lineage specification factor for Tregs...
  2. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
    The role of FoxP3(+)CD4(+) regulatory T (Treg) cells in HIV-1 disease in vivo is poorly understood due to the lack of a robust model...
  3. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
    ..This finding firmly establishes the role of IFIH1 in T1D and demonstrates that resequencing studies can pinpoint disease-causing genes in genomic regions initially identified by GWASs...
  4. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..but depends on distinct transcription factors: RORgammat (encoded by Rorc(gammat)) for T(H)17 cells and Foxp3 for T(reg) cells...
  5. pmc Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer
    Mia Kim
    Department of Surgery I, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 8:e53630. 2013
    Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression...
  6. ncbi Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:129-38. 2007
    b>Foxp3 plays a key role in CD4+ CD25+ T(reg) cell function in mice and represents a specific marker for these cells...
  7. doi FOXP3 expression and overall survival in breast cancer
    Andrea Merlo
    Molecular Biology Unit, Department of Experimental Oncology, Pathology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori and the Institute of Pathology, University of Milan, Milan, Italy
    J Clin Oncol 27:1746-52. 2009
    The transcription factor forkhead box P3 (FOXP3) up- or downregulates a large number of genes and has been recently reported to be expressed in tumor cells...
  8. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
    ..In this study, we report that human peripheral blood and lymphoid tissue contain a significant number of CD4(+)FOXP3(+) T cells that express CCR6 and have the capacity to produce IL-17 upon activation...
  9. pmc FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    Tao Zuo
    Program in Molecular, Cellular, and Developmental Biology and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Cell 129:1275-86. 2007
    ..Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate...
  10. ncbi Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis
    Valerie Guyot-Revol
    Tuberculosis Immunology Group, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 7, Oxford OX3 9DU, UK
    Am J Respir Crit Care Med 173:803-10. 2006
    ..CD4+CD25(high) regulatory T cells mediate suppressed cellular immunity in several chronic infections but have not been described in TB...
  11. ncbi Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
    The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions...
  12. pmc Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors
    Katy Milne
    Trev and Joyce Deeley Research Centre, BC Cancer Agency, Victoria, British Columbia, Canada
    PLoS ONE 4:e6412. 2009
    ..Tumor-infiltrating T cells are associated with survival in epithelial ovarian cancer (EOC), but their functional status is poorly understood, especially relative to the different risk categories and histological subtypes of EOC...
  13. ncbi In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma
    Marc Beyer
    Molecular Tumor Biology and Tumor Immunology, Clinic I for Internal Medicine, University of Cologne, Joseph Stelzmann Strasse 9 Haus 16, 50931 Cologne, Germany
    Blood 107:3940-9. 2006
    ..premalignant monoclonal gammopathy of undetermined significance and patients with multiple myeloma that functional FoxP3(+) T(reg) cells of naive, central, and effector memory phenotype as determined by CCR7 and CD45RA expression are ..
  14. pmc Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers
    Weiquan Li
    Departments of Surgery, Pathology, and Internal Medicine, Division of Immunotherapy, University of Michigan School of Medicine and Cancer Center, Ann Arbor, Michigan 48109, USA
    Cancer Res 71:2162-71. 2011
    ..Here we report that spontaneous mutation of the transcription factor FOXP3 reduces expression of the LATS2 gene in mammary epithelial cells...
  15. pmc CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines
    Anne M Pesenacker
    Rheumatology Unit, UCL Institute of Child Health, University College London, London, United Kingdom
    Blood 121:2647-58. 2013
    Regulatory FoxP3+CD4+ T cells (Treg) are vital for maintaining the balance between tolerance, adequate immune response, and autoimmunity...
  16. ncbi X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    R S Wildin
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland, USA
    Nat Genet 27:18-20. 2001
    ..We found four non-polymorphic mutations. Each mutation affects the forkhead/winged-helix domain of the scurfin protein, indicating that the mutations may disrupt critical DNA interactions.
  17. pmc Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    Roopali Gandhi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:846-53. 2010
    ..We found that AhR activation promoted the differentiation of CD4(+)Foxp3(-) T cells, which produce IL-10 and control responder T cells through granzyme B...
  18. doi Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor
    Makoto Miyara
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Immunity 30:899-911. 2009
    b>FoxP3 is a key transcription factor for the development and function of natural CD4(+) regulatory T cells (Treg cells)...
  19. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
    ..In contrast, these changes were opposite, absent or partial in the OBS population. These findings support the use of Tat immunization to intensify HAART efficacy and to restore immune homeostasis...
  20. doi Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans
    Megan E Himmel
    Department of Surgery, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada
    J Immunol 190:2001-8. 2013
    b>FOXP3-expressing T regulatory cells (Tregs) can be divided into two distinct subsets: naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) that differentiate in peripheral tissues upon exposure to Ag ..
  21. pmc Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate
    Lizhong Wang
    Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA
    Cancer Cell 16:336-46. 2009
    ..Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer...
  22. ncbi FOXP3 ensembles in T-cell regulation
    Bin Li
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Immunol Rev 212:99-113. 2006
    Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ..
  23. pmc IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    Emmanuel Zorn
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 108:1571-9. 2006
    IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3(+) regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs...
  24. pmc Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Clin Invest 116:1713-22. 2006
    ..polyendocrinopathy, enteropathy, X-linked (IPEX) is caused by mutations in the forkhead box protein P3 (FOXP3) gene...
  25. pmc Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    Maha Ayyoub
    Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre Rene Gauducheau, 44800 Saint Herblain, France
    Proc Natl Acad Sci U S A 106:8635-40. 2009
    Recent studies have suggested a close relationship between CD4(+)FOXP3(+) regulatory T cells (Tregs) and proinflammatory IL-17-producing T helper cells (T(H)17) expressing the lineage-specific transcription factor RORgamma t...
  26. pmc FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
    Bin Li
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 104:4571-6. 2007
    The forkhead family protein FOXP3 acts as a repressor of transcription and is both an essential and sufficient regulator of the development and function of regulatory T cells...
  27. doi The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells
    Lisa M Ebert
    Ludwig Institute for Cancer Research Melbourne Center for Clinical Sciences, Austin Health, Heidelberg, Victoria, Australia
    Cancer Res 68:3001-9. 2008
    b>FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg)...
  28. pmc Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation
    Wei Duan
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 920370, USA
    J Immunol 187:6499-507. 2011
    ..We report that inhaled soluble Ag induces adaptive Foxp3(+) Tregs, as well as a regulatory population of CD4(+) T cells in the lungs and lung-draining lymph nodes that ..
  29. pmc Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach
    M Yoshii
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1 4 3, Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Br J Cancer 106:1668-74. 2012
    It was recently reported that the transcription factor Forkhead box P3 (FoxP3) is expressed not only in regulatory T cells (Tregs) but also in cancer cells...
  30. doi Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer
    Hai Yan Zhang
    The Hospital of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, PR China
    Cancer Lett 287:91-7. 2010
    The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs)...
  31. pmc Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3
    Kian Peng Koh
    Department of Pathology, Harvard Medical School and Immune Disease Institute, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8109. 2009
    The forkhead, winged-helix transcription factor FOXP3 is preferentially expressed in T regulatory (Treg) cells and is critical for their immunosuppressive function...
  32. doi Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
    Hiroyuki Tao
    Department of Thoracic Surgery, NHO Yamaguchi Ube Medical Center, 685 Higashi Kiwa, Ube, 755 0241, Japan
    Lung Cancer 75:95-101. 2012
    Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that engage in the maintenance of immunological self-tolerance and immune homeostasis...
  33. doi Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy
    Nicolette Moes
    Universite Paris Descartes, Paris, France
    Gastroenterology 139:770-8. 2010
    ..AIE has been associated with mutations in FOXP3-a transcription factor that controls regulatory T-cell development and function...
  34. doi Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner
    Xiang Liang Yuan
    Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, China
    Clin Immunol 134:277-88. 2010
    The transcription factor Foxp3 plays a key role in CD4(+)CD25(+) regulatory T (Treg) cell function. A correlation has been shown between survival and the frequency of tumor-infiltrating Foxp3-positive Treg cells in cancer patients...
  35. doi STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
    Laura Passerini
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Int Immunol 20:421-31. 2008
    Forkhead box P3 (FOXP3) is considered a specific marker for CD4(+)CD25(+) regulatory T (Treg) cells, but increasing evidence suggests that human CD4(+)CD25(-) effector T (Teff) cells can transiently express FOXP3 upon activation...
  36. doi High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients
    Daniel M Frey
    Department of Surgery, University Hospital of Basel, Basel, Switzerland
    Int J Cancer 126:2635-43. 2010
    ..The transcription factor forkhead box P3 (FOXP3) is an intracellular key molecule for T(reg) development and function and is considered to represent the most ..
  37. pmc FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
    Tao Zuo
    Department of Surgery, Section of General Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 117:3765-73. 2007
    ..We recently demonstrated that forkhead box P3 (FOXP3) is an X-linked breast cancer suppressor and an important repressor of the oncogene ERBB2/HER2...
  38. pmc Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer
    Aaron S Mansfield
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    BMC Cancer 9:231. 2009
    ..Our aim was to assess whether expression of Foxp3, a marker of Tregs, and IDO were linked with nodal metastasis in breast cancer patients...
  39. pmc FOXP3 promoter demethylation reveals the committed Treg population in humans
    Peter C J Janson
    Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e1612. 2008
    ..The transcription factor FOXP3 is crucial for the suppressive activity of Tregs and is considered the most specific marker for this population...
  40. doi Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity
    Eleonora Gambineri
    Department of Pediatrics, Anna Meyer University Children s Hospital, University of Florence, Florence, Italy
    J Allergy Clin Immunol 122:1105-1112.e1. 2008
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune genetic disorder caused by mutation of the forkhead box protein 3 gene (FOXP3), a key regulator of immune tolerance.
  41. pmc Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3
    Yong Zheng
    Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 181:1683-91. 2008
    ..We have examined the role of CTLA-4 and its relationship with the transcription factor FoxP3 using a model of Treg induction in human peripheral blood...
  42. pmc Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis
    E Bourreau
    Immunologie des Leishmanioses, Institut Pasteur de la Guyane, 97306 Cayenne, French Guyana
    Infect Immun 77:1465-74. 2009
    The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL)...
  43. doi Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    Jorg van Loosdregt
    Molecular Immunology Lab, Department of Immunology, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Blood 115:965-74. 2010
    ..Expression levels of the transcription factor Foxp3 have been causally associated with Treg differentiation and function...
  44. ncbi Transcriptional regulation by Foxp3 is associated with direct promoter occupancy and modulation of histone acetylation
    Chunxia Chen
    Joseph Stokes, Jr Research Institute, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:36828-34. 2006
    Regulatory T cells (T(reg)) express Foxp3, a forkhead family member that is necessary and sufficient for T(reg) lineage choice and function...
  45. pmc Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
    Fan Pan
    Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Science 325:1142-6. 2009
    ..program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-..
  46. doi Decreased FOXP3 protein expression in patients with asthma
    S Provoost
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Allergy 64:1539-46. 2009
    ..In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma.
  47. pmc Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
    Mindi R Walker
    Diabetes Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, Washington 98101, USA
    J Clin Invest 112:1437-43. 2003
    ..Recently, the forkhead/winged helix transcription factor, FoxP3, has been shown to be important for the function of TR cells in mice...
  48. ncbi The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    C L Bennett
    Division of Genetics and Development, Department of Pediatrics, University of Washington, Seattle, USA
    Nat Genet 27:20-1. 2001
    ..We present genetic evidence that different mutations of the human gene FOXP3, the ortholog of the gene mutated in scurfy mice (Foxp3), causes IPEX syndrome...
  49. ncbi Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    M E Brunkow
    Celltech Chiroscience, Inc, Bothell, Washington, USA
    Nat Genet 27:68-73. 2001
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.
  50. ncbi DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    Udo Baron
    Epiontis GmbH, Berlin, Germany
    Eur J Immunol 37:2378-89. 2007
    The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg)...
  51. doi Negligible nuclear FOXP3 expression in breast cancer epithelial cells compared with FOXP3-positive T cells
    Raoul A Droeser
    Institute of Pathology, University Hospital Basel, Basel, Switzerland
    Clin Breast Cancer 13:264-70. 2013
    The presence of forkhead box protein 3 (FOXP3) in breast cancer cells is a matter of debate. We systematically analyzed expression of FOXP3 in 1574 breast carcinomas.
  52. doi Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients
    Jia Zhou
    State Key Laboratory of Biocontrol, Sun Yat Sen Zhongshan University, Guangzhou, People s Republic of China
    Int J Cancer 125:1640-8. 2009
    ..This study investigated the properties of FoxP3(+) Tregs, their prognostic value in patients with hepatocellular carcinoma (HCC) and the underlying mechanisms of ..
  53. pmc ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells
    Andreas Jeron
    Immune Regulation Group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, Braunschweig, 38124, Germany
    BMC Genomics 13:705. 2012
    The transcription factor (TF) forkhead box P3 (FOXP3) is constitutively expressed at high levels in naturally occurring CD4+CD25+ regulatory T cells (nTregs)...
  54. doi Foxp3+ regulatory T cells are associated with the natural history of chronic hepatitis B and poor prognosis of hepatocellular carcinoma
    Fengmei Wang
    Department of Gastroenterology and Hepatology, The Third Central Clinical College of Tianjin Medical University, Tianjin, China
    Liver Int 32:644-55. 2012
    ..Recent studies have focused on regulatory T cells (Tregs) in chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC) and they were also conducted independently of each other...
  55. pmc FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration
    Véronique Frattini
    Unit of Molecular Neuro Oncology, Fondazione I R C C S Istituto Neurologico C Besta, Milan, Italy
    Oncotarget 3:1146-57. 2012
    The transcription factor FOXP3 plays an essential role in regulatory T cell development and function. In addition, it has recently been identified as a tumor suppressor in different cancers...
  56. doi FOXP3 germline polymorphisms are not associated with risk of breast cancer
    Leon Raskin
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Genet Cytogenet 190:40-2. 2009
    Recent studies have characterized X-linked transcriptional regulator FOXP3 as a tumor suppressor gene involved in the pathogenesis of breast cancer...
  57. pmc FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus
    Runhua Liu
    Division of Immunotherapy and Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, Michigan, USA
    Cancer Res 69:2252-9. 2009
    ..Here, we report that X-linked tumor suppressor FOXP3 is essential for p21 expression in normal epithelia and that lack of FOXP3 is associated with p21 down-regulation ..
  58. pmc Intraepithelial effector (CD3+)/regulatory (FoxP3+) T-cell ratio predicts a clinical outcome of human colon carcinoma
    Frank A Sinicrope
    Miles and Shirley Fiterman Digestive Disease Center, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 137:1270-9. 2009
    Regulatory T cells (Tregs) express the forkhead box transcription factor (FoxP3) and suppress the antitumor immune response...
  59. doi Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression
    Masashi Sakaki
    Division of Gastroenterology, Department of Medicine Clinical Research Laboratory, Showa University School of Medicine, Tokyo, Japan
    Hepatol Res 40:1219-26. 2010
    ..COX-2) and osteopontin (OPN) promoter regions and a promoter/enhancer region of forkhead box protein 3 (FOXP3) gene are known to affect immune responses, we examined whether these polymorphisms can influence susceptibility ..
  60. doi Increased CTLA-4 and FOXP3 transcripts in peripheral blood mononuclear cells of patients with breast cancer
    Mansooreh Jaberipour
    Cancer Gene Therapy Laboratory, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
    Pathol Oncol Res 16:547-51. 2010
    ..These cells express Forkhead/winged helix transcription factor (FOXP3) and also Cytotoxic T-lymphocyte antigen-4 (CTLA-4), as a negative regulatory molecule which, is a potential ..
  61. doi Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study
    Y C Lin
    Department of Pediatrics, Lotung Poh Ai Hospital, Taiwan
    Lupus 20:137-43. 2011
    b>Foxp3, encoded by the human FOXP3 gene, is a transcription factor that regulates regulatory T-cell (Treg) development and function...
  62. doi Analysis of FOXP3 polymorphisms in infertile women with and without endometriosis
    Gustavo M André
    Division of Pathological Gynecology and Human Reproduction, Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC, Santo Andre, Brazil
    Fertil Steril 95:2223-7. 2011
    To evaluate FOXP3 polymorphisms (rs3761549, rs3761548, rs2232368, rs2232366, and rs2280883) in a group of infertile women with and without endometriosis and controls.
  63. pmc Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity
    Reiner K W Mailer
    Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    PLoS ONE 4:e6104. 2009
    Phenotype and function of regulatory T cells (Treg) largely depend on the presence of the transcription factor FOXP3. In contrast to mice, human Treg cells express isoforms of this protein...
  64. doi Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
    M I Vargas-Rojas
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Lupus 17:289-94. 2008
    ..In the present work, we quantified CD4+FOXP3+ Treg cells in patients with SLE and found no quantitative alterations...
  65. doi Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma
    W Y Kim
    Department of Pathology, Seoul National University Hospital, Seoul, Korea
    Ann Oncol 20:1688-96. 2009
    ..Recently, tumor microenvironment including regulatory T cells (Tregs) has been implicated as a prognostic marker in certain types of lymphoma...
  66. pmc Increase in circulating Foxp3+CD4+CD25(high) regulatory T cells in nasopharyngeal carcinoma patients
    K M Lau
    Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
    Br J Cancer 96:617-22. 2007
    ..These were regulatory T cells (Treg), as they overexpressed Foxp3 and GITR, and demonstrated enhanced suppressive activities against autologous CD4+CD25- T-cell proliferation in ..
  67. pmc Effects of natalizumab treatment on Foxp3+ T regulatory cells
    Max Philipp Stenner
    Department of Neurology, Julius Maximilians University, Wuerzburg, Germany
    PLoS ONE 3:e3319. 2008
    ..Our objective was to study impacts of Natalizumab therapy on Foxp3+ T regulatory cells (Tregs) in multiple sclerosis (MS) patients.
  68. ncbi Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    Masahiro Ono
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Nature 446:685-9. 2007
    ..T(R) cells specifically express the transcription factor Foxp3, a key regulator of T(R)-cell development and function...
  69. ncbi Number of CD4+ cells and location of forkhead box protein P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome
    Abigail M Lee
    Cancer Research UK, Medical Oncology Unit, St Bartholomew s Hospital, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 24:5052-9. 2006
    ..To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance...
  70. doi Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Respirology 14:187-94. 2009
    A forkhead/winged-helix family transcriptional repressor, Foxp3, is highly expressed on CD4(+)CD25(+) T regulatory cells. The role of Foxp3(+)CD4(+)CD25(+) T regulatory cells in asthma remains to be elucidated...
  71. ncbi The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    Dominik Wolf
    Division of Hematology and Oncology, Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Clin Cancer Res 11:8326-31. 2005
    The forkhead box transcription factor FoxP3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg were described to be associated with poor survival in different malignancies...
  72. doi Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin
    H Jorn Bovenschen
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Invest Dermatol 131:1853-60. 2011
    ..In addition, CD4+CD25(high) regulatory T-cell (Treg) function appeared to be impaired in psoriasis. CD4+CD25(high)Foxp3+ Tregs are typically considered inhibitors of autoimmune responses...
  73. pmc FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1
    Hiroto Katoh
    Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA
    Mol Cell 44:770-84. 2011
    ..Here, we analyzed the mechanism of the transcriptional activation by FOXP3, an X-linked suppressor of autoimmune diseases and cancers...
  74. ncbi Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada
    Int Immunol 19:345-54. 2007
    Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4(+)CD25(+) T regulatory cells (nTregs)...
  75. pmc Rapid temporal control of Foxp3 protein degradation by sirtuin-1
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19047. 2011
    Maintenance of Foxp3 protein expression in regulatory T cells (Treg) is crucial for a balanced immune response...
  76. pmc Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation
    Amanda J Chase
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 82:8307-15. 2008
    ..data suggest that both direct infection by HIV-1 and tissue redistribution are possible explanations for declining FoxP3(+) Tregs in progressive HIV-1 infection...
  77. doi Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population
    Susanne A Hanel
    Institute for Tropical Medicine, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
    Immunogenetics 63:409-15. 2011
    ..We identified and investigated regulatory SNPs in the promoter region of the FOXP3 gene in a group of Gabonese individuals exposed to a variety of parasitic infections...
  78. ncbi High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 108:2957-64. 2006
    ..To determine the impact of FOXP3-positive regulatory T cells (Tregs) in the progression and outcome of FL patients, we examined samples from 97 ..
  79. pmc FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy
    Hazem Ghebeh
    Tumor Immunology Section, King Faisal Specialist Hospital and Research Center, P, O, Box 3354, Riyadh 11211, Saudi Arabia
    BMC Cancer 8:57. 2008
    Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape of cancer...
  80. pmc Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)
    I Kobayashi
    J Med Genet 38:874-6. 2001
  81. ncbi Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases
    Julie Massayo Maeda Oda
    Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, Campus Universitário CEP 86051 990 Londrina, Brazil
    J Genet 92:163-71. 2013
    The FOXP3 gene encodes a transcription factor thought to be important for the development and function of regulatory T cells (Treg cells)...
  82. pmc CCR7 expression and intratumoral FOXP3+ regulatory T cells are correlated with overall survival and lymph node metastasis in gastric cancer
    Shuang Zhou
    Department of Histology and Embryology, Tongji University School of Medicine, Shanghai, China
    PLoS ONE 8:e74430. 2013
    ..The aim of this study was to investigate the prognostic value of chemokine receptor CCR7 expression and intratumoral FOXP3(+) regulatory T cells (Tregs) in gastric cancer...
  83. pmc Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients
    Benedikt Fritzsching
    Department of Neonatology, Center for Child and Adolescent Medicine, University Hospital of Heidelberg, Heidelberg, Germany
    PLoS ONE 6:e17988. 2011
    Impaired suppressive capacity of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) from peripheral blood of patients with multiple sclerosis (MS) has been reported by multiple laboratories...
  84. doi FOXP3 expression is related to high Ki-67 index and poor prognosis in lymph node-positive breast cancer patients
    Min Hwan Kim
    Division of Medical Oncology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
    Oncology 85:128-36. 2013
    Recent preclinical studies have shown that Forkhead box protein 3 (FOXP3) is an important tumor suppressor gene. The clinical and prognostic implication of FOXP3 expression in breast cancer cells still remains controversial.
  85. pmc FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China
    Yanhui Chen
    Peking University People s Hospital, Peking University Hepatology Institute, NO, 11 Xizhimen South Street, Beijing 100044, China
    J Exp Clin Cancer Res 32:39. 2013
    Previous evidence has shown that the FOXP3 gene was involved in the pathogenesis of several tumors; however, the correlation between single nucleotide polymorphisms (SNPs) in the FOXP3 gene and the susceptibility to hepatitis B-related ..
  86. ncbi Correlation between elevated FOXP3 expression and increased lymph node metastasis of gastric cancer
    Li Hong Wang
    Department of Gastroenterology, Peking University People s Hospital, Beijing 100044, China
    Chin Med J (Engl) 123:3545-9. 2010
    b>FOXP3 was thought to express in the T-cell lineage exclusively until recently when FOXP3 was shown to be expressed by cancer cells...
  87. doi Polymorphisms in the FOXP3 gene in Han Chinese psoriasis patients
    Lin Gao
    Department of Dermatology of Xijing Hospital, Fourth Military Medical University, Xi an 710032, Shaanxi, China
    J Dermatol Sci 57:51-6. 2010
    ..T-regs express the fork head/winged helix transcription factor, FOXP3, which appears to be of key importance in the development and function of T-regs...
  88. doi Role of Foxp3-positive tumor-infiltrating lymphocytes in the histologic features and clinical outcomes of hepatocellular carcinoma
    Alka Mary Mathai
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    Am J Surg Pathol 36:980-6. 2012
    The role of Foxp3-positive regulatory T cells (Foxp3 Tregs) in suppression of antitumoral immune response is well documented in patients with cancer...
  89. doi Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy
    Sylvain Ladoire
    Department of Medical Oncology, Centre Regional de Lutte Contre Cancer Georges François Leclerc, Dijon, France
    Breast Cancer Res Treat 125:65-72. 2011
    ..We investigated the prognostic significance of Foxp3 expression in cancer cells in a large cohort of patients with HER2-overexpressing breast carcinoma treated with ..
  90. pmc Staphylococcus aureus convert neonatal conventional CD4(+) T cells into FOXP3(+) CD25(+) CD127(low) T cells via the PD-1/PD-L1 axis
    Hardis Rabe
    Department of Rheumatology and Inflammation Research, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
    Immunology 141:467-81. 2014
    ..The proportion of circulating CD25(+) CD127(low) Treg cells and their expression of FOXP3, Helios and CTLA-4 was examined in newborns and adults...
  91. pmc FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity
    Nithianandan Selliah
    Division of Rheumatology, Department of Pediatrics, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Virology 381:161-7. 2008
    b>FOXP3 is a necessary transcription factor for the development and function of CD4+ regulatory T-cells (Tregs). The role of Tregs in HIV-1 infection remains unclear...
  92. ncbi Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas
    C D Klemke
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Leukemia 20:1123-9. 2006
    ..In this study, we investigated cutaneous expression of the regulatory T-cell (T(reg)) marker FOXP3 in 30 CTCL patients...
  93. pmc Prognostic value of tumor-infiltrating FoxP3+ T cells in gastrointestinal cancers: a meta analysis
    Yong Huang
    Tianjin Medical University, Tianjin, China Department of Hepatobiliary Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China
    PLoS ONE 9:e94376. 2014
    Tumor-infiltrating FoxP3+ T cells have been reported in various human tumors, which impaired cell-mediated immunity and promoted disease progression...
  94. pmc 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region
    Seong Wook Kang
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 188:5276-82. 2012
    b>FOXP3-positive regulatory T (Treg) cells are a unique subset of T cells with immune regulatory properties...
  95. doi FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human
    Alvin W L Schadenberg
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 41:1132-42. 2011
    Tregs are crucial in controlling inflammation. Although the transcription factor FOXP3 is the most applicable phenotype marker of Tregs, it does not indisputably characterize suppressive function during T-cell activation in vitro...
  96. ncbi Relationship and clinical significance of TGF-beta1 expression with Treg cell infiltration in hepatocellular carcinoma
    Guo He Lin
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, PR China
    Chin J Cancer 29:403-7. 2010
    ..This study was to investigate the expression of TGF-beta1 and correlations with the amount of Treg cells in HCC, and to evaluate their clinical values in predicting the prognosis of HCC...
  97. pmc High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment
    G F Ma
    Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China
    Br J Cancer 110:1552-60. 2014
    Forkhead Box P3 (FoxP3) is thought to be a key transcription factor in regulatory T cells (Tregs), and recent data indicate that it is expressed in several tumour cells...
  98. ncbi Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    L A Schubert
    Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101, USA
    J Biol Chem 276:37672-9. 2001
    ..in these mice and in humans with mutations in the orthologous gene indicates that the foxp3 gene product, scurfin, is involved in the regulation of T cell activation and differentiation...
  99. doi Up-regulation of Foxp3 participates in progression of cervical cancer
    Chao Zeng
    Department of Pathology, Guangdong Medical College, Dongguan, 523808, China
    Cancer Immunol Immunother 62:481-7. 2013
    b>Foxp3 was identified as a key protein in mediating inhibitory functions of regulatory T cell (Treg)...
  100. doi TGF-β1 secreted by hepatocellular carcinoma induces the expression of the Foxp3 gene and suppresses antitumor immunity in the tumor microenvironment
    Yi Wang
    The Department of Gastroenterology of Zhongshan Hospital, Fudan University, 180 Fenglin Rd, Shanghai, 200032, People s Republic of China
    Dig Dis Sci 58:1644-52. 2013
    ..The purpose of this study was to explore the mechanisms of TGF-β1 mediated immunosuppression in tumor stroma...
  101. doi Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response
    Lei Sun
    Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, China
    Transpl Immunol 26:71-80. 2012
    Naturally occurring CD4+CD25+ regulatory T cells (nTregs) that express high level of Foxp3 actively suppress pathological and physiological immune responses, contributing to the maintenance of immunological self-tolerance and immune ..

Research Grants105 found, 100 shown here

  1. Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
    Prabir Ray; Fiscal Year: 2013
    ..Our preliminary data show the presence of Tregs co- expressing Foxp3 and GATA-3 in RSV infected lungs, which is attenuated in IL-4R-deficient mice...
  2. In vivo assessment of T cell kinetics in individuals at risk for Type 1 diabetes
    Carla J Greenbaum; Fiscal Year: 2013
    ..We and others have found evidence of impaired signaling through the IL-2R, and diminished maintenance of FOXP3 expression in T1D subjects consistent with studies in mice which suggest Treg turnover may have important ..
  3. The IRF - type I interferon system in T cell-mediated immune tolerance
    Michael David; Fiscal Year: 2013
    ..We will further investigate the mechanism why STAT1-deficient FoxP3+ cells fail to suppress effector T cells, and whether interferon can alter the conversion of conventional effector ..
  4. Engineering DNA nanoparticles to create immune tolerance
    ANDREW LEE MELLOR; Fiscal Year: 2013
    ..IDO, and DCs expressing IDO suppress T cell responses, in part by stabilizing the default regulatory phenotypes of Foxp3-lineage CD4 T cells (Tregs). Thus reagents that induce IDO and activate Tregs may ameliorate autoimmune diseases...
  5. Characterization of Human Regulatory T cell-induced Dendritic Cells
    MICHAEL ALONSO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): CD4+CD25+Foxp3+ T regulatory cells (Tregs) and dendritic cells (DCs) are central to the immunosuppressive environment characteristic of many types of cancer including breast cancer...
  6. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..of Treg have been identified, the best characterized ones, including subsets that express the transcription factor Foxp3, and ones that produce IL-10, will be studied in the proposed experiments...
  7. Innate Regulation and CD4+Th1/17 Immunity in TMEV-Induced Demyelination
    Stephen D Miller; Fiscal Year: 2013
    ..depletion, supplementation and genetic approaches, Aim 1 will test the hypothesis that activation of CD4+CD25+Foxp3+ Tregs plays a major role in regulating susceptibility to TMEV-IDD by inhibiting development of virus-specific CD4,..
  8. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..cells will be identified in placental sections by immunofluorescent labeling with antibodies to CD4, CD25, and FoxP3. Confocal microscopy will be used to quantify these cells...
  9. Viral Infection and Impairment of Immune Tolerance
    Prabir Ray; Fiscal Year: 2012
    ..Collectively, we have exciting data that show the presence of Tregs expressing Foxp3 and GATA-3 in RSV infected lungs, which is promoted by Th2-type cytokines induced by the virus and attenuated by ..
  10. Control of Treg Homeostasis and Function by the Lipid Phosphatase PTEN
    Laurence A Turka; Fiscal Year: 2013
    ..The primary population of Tregs in humans and mice is defined by expression of the X-linked transcription factor Foxp3. While these cells are required for normal immune homeostasis increasing data suggests that this lineage of cells ..
  11. Homing and Homeostasis of Regulatory T cells
    Daniel J Campbell; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): CD4+ regulatory T cells (TR) expressing the transcription factor Foxp3 are potent anti-inflammatory cells that dampen immune responses to both self- and foreign-antigens...
  12. Epigenetic Control of T cell Autoimmunity
    Daniel L Mueller; Fiscal Year: 2010
    ..Specific Aim 1 will investigate the individual roles of NT5'E and Foxp3 in the development and maintenance of clonal anergy following initial self antigen encounter by polyclonal CD4+ T ..
  13. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2013
    ..these issues we propose the following specific aims:1) To further characterize the relevance of TCR diversity in Foxp3+ regulatory T cells by evaluating the efficacy and durability of Treg cells with limited diversity to suppress ..
  14. TREATMENT OF AUTOIMMUNITY WITH REGULATORY T LYMPHOCYTES
    Terrence L Geiger; Fiscal Year: 2013
    ..cells can be modulated by different forms of regulatory T lymphocytes (Treg), most prominently Treg expressing the Foxp3 transcription factor...
  15. An Immune Tolerance Strategy for Prevention and Treatment of Atherosclerosis
    JAYME contact BORENSZTAJN; Fiscal Year: 2011
    ..that tolerance induced by antigen-coupled cells is due, at least in part, to the up-regulation of CD4+CD25+FoxP3+ regulatory T cells (Tregs) that function in the suppression of pathogenic T cells...
  16. The IL-2 receptor in T regulatory cell development
    Thomas R Malek; Fiscal Year: 2012
    CD4+ Foxp3+ T regulatory (Treg) cells are essential for immune tolerance. It is now appreciated that signaling through IL2R is mandatory for Treg cells...
  17. Analysis of Lag-3 in Regulatory T Cell Function and Immune Supression
    Charles G Drake; Fiscal Year: 2012
    ..Studies in humans have demonstrated increased LAG-3 expression on tumor-infiltrating FoxP3+ regulatory T cells...
  18. T regulatory cell suppression of CD8+ cell responses during FIV Infection
    JONATHAN FOGLE; Fiscal Year: 2012
    ..PBMC/LN will be phenotyped for surface receptors by flow cytometry, and for Foxp3 mRNA by RT-PCR...
  19. Intestinal Antigen Presenting Cells and Mucosal Immunity
    Timothy L Denning; Fiscal Year: 2013
    ..that steady state CX3CR1-expressing LP macrophages are major producers of IL-10 and are adept at promoting Foxp3+ Treg cell differentiation in an IL-10- and retinoic acid-dependent manner...
  20. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2013
    ..Also, stronger immunoreactivity of Foxp3, IL-10 and CD25 with preponderance of CD4? T cells in carotid plaques of asymptomatic than symptomatic patients...
  21. Dendritic Cells, Rapamycin and Transplant Tolerance
    Angus W Thomson; Fiscal Year: 2010
    ..treated DC (RAPA-DC) induce alloAg-specific T cell hyporesponsiveness in vitro and in vivo and expand CD4+CD25*Foxp3+ T regulatory cells (Treg) in vitro...
  22. T CELL RESPONSE TO MYELIN PROTEOLIPID PROTEIN
    Vijay K Kuchroo; Fiscal Year: 2013
    ..Since Tregs express the Fox-P3 transcription factor, we have generated a Foxp3- EGFP "knock-in" mouse strain in order to track CD4+ CD25+ Fox-P3+ Tregs by GFP-expression...
  23. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
  24. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..Interleukin-17 (IL-17)-producing T helper 17 (Th17) cells and forkhead box P3 (FOXP3)-positive regulatory T cells (hereafter called FOXP3+ Treg) play major roles in autoimmunity and inflammation...
  25. TLR2 and the Tubercle Granuloma
    Padmini Salgame; Fiscal Year: 2013
    ..The infected lungs of TLR2KO mice exhibited enhanced inflammation associated with reduced infiltration of FoxP3[+] T regulatory cells (Tregs) into the lung, while lungs from infected WT animals had resolved their inflammation ..
  26. Reversal of CMV-specific immune deficits in patients with glioblastoma
    Duane Anthony Mitchell; Fiscal Year: 2013
    ..in vitro using pp65 RNA pulsed DCs coupled with addition of exogenous IL-2 or through the removal of CD4+CD25+FOXP3+ regulatory T cells (Tregs) prior to stimulation...
  27. Overcoming Immune Suppression to Enhance Tumor Vaccine Efficacy
    Si Yi Chen; Fiscal Year: 2013
    ..neuropilin (Nrp) 1 blocks the ability of DCs to activate latent TGF-[unreadable], reducing their ability to induce Foxp3 expression and convert conventional T cells into Treg cells. And 3...
  28. TLR2 and the Tubercle Granuloma
    Padmini Salgame; Fiscal Year: 2010
    ..The infected lungs of TLR2KO mice exhibited enhanced inflammation associated with reduced infiltration of FoxP3+ T regulatory cells (Tregs) into the lung, while lungs from infected WT animals had resolved their inflammation ..
  29. AhR activation in Th17 and Treg cell differentiation
    Liang Zhou; Fiscal Year: 2013
    ..ROR?t and Foxp3 have been shown to be the key transcription factors in specifying differentiation programs of Th17 and Treg ..
  30. Therapeutic Immunoregulation Mediated by TGF-beta-induced iTregs in Autoimmune Ar
    Song Guo Zheng; Fiscal Year: 2013
    ..nTreg or iTregs will be sorted or induced from DBA/1 Foxp3-GFP knock-in mice or Foxp3-GFP/IL-17-RFP double knock-in mice...
  31. Consequences of Aging on Immune Response and Transplant Outcome
    STEFAN GUNTHER TULLIUS; Fiscal Year: 2013
    ..At the same time, we observed a well preserved suppressor function of old alloantigen-specific CD4+CD25+FoxP3+ T cells...
  32. Mechanisms of Disease Pathogenesis in Regulatory T cell Deficiency
    Calvin B Williams; Fiscal Year: 2013
    CD4+Foxp3+ regulatory T (TR) cells are crucial to the maintenance of peripheral tolerance. Natural regulatory T (nTR) lymphocytes are a distinct thymus-derived lineage...
  33. A Novel Therapy for Restricted Induction of Tolerance to Treat Diabetes Mellitus
    Kanneganti Murthy; Fiscal Year: 2013
    ..T1D may result from excess pathogenic Th1/Th17 cells and deficient tolerance-inducing antigen (Ag)-specific Treg (FOXp3+CD25+) and Tr1 CD4+ cells (FOXp3-CD25- IL-10high)...
  34. Generation of Regulatory T cells ex-vivo for the treatment of systemic lupus eryt
    DAVID O'NEIL; Fiscal Year: 2011
    ..Principal developmental milestones will be to show that: 1) the product stably expresses Foxp3;2) the product has significant suppressive activity on autologous T cells both in vitro and in vivo in ..
  35. MECHANISMS OF THE INDUCTION OF ORAL TOLERANCE
    Howard L Weiner; Fiscal Year: 2013
    ..Tregs and we have found that the aryl hydrocarbon receptor (AHR) plays an important role in the differentiation of FoxP3+ Treg and IL10+ Tr1 cells...
  36. BCL11B in Immune Regulation
    Dorina Avram; Fiscal Year: 2013
    ..The transcriptio factor Foxp3 is crucial for Treg cell development and function, and mutations at the Foxp3 locus cause lymphoproliferative ..
  37. T Cell Tolerance &Autoimmunity to Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2012
    ..these T cells depends on the level of antigen presentation in the recipients and that the in vivo cues promoting Foxp3+ regulatory T cells in this system differ from those previously described...
  38. Reconstitution of Regulatory T Cells After Stem Cell Transplantation
    ROBERT JON SOIFFER; Fiscal Year: 2013
    ..Expanded Treg express FoxP3 and retain functional suppressive activity...
  39. Role of Macrophage Regulatory Cells (Mac-regs) in Immune Regulation
    Joseph Lustgarten; Fiscal Year: 2010
    ..provided by applicant): We have identified a new population of CD11b+F4/80+CD68+ (macrophages) that express Foxp3. Our initial results indicate that these cells were observed in spleen, lymph nodes, bone marrow, thymus, ..
  40. Extracellular matrix and the function and stability of FoxP3+ regulatory T-cells
    Paul L Bollyky; Fiscal Year: 2013
    ..a component of the extracellular matrix (ECM) of injured and healing tissues, in the function and stability of Foxp3+ regulatory T-cells (Treg), a T-cell subset critical to the maintenance of immune tolerance...
  41. MECHANISMS OF ANTIGEN INDUCED TOLERANCE IN THE LUNG
    Anuradha Ray; Fiscal Year: 2013
    ..a murine model of tolerance induced by inhaled Ag, we previously identified regulatory T cells (Tregs) expressing Foxp3 and membrane-bound TGF-[unreadable] (mTGF-[unreadable]) that functionally suppressed allergic airway inflammation ..
  42. Extracellular matrix and immune regulation in autoimmune diabetes
    Paul L Bollyky; Fiscal Year: 2013
    ..HMW-HA), a component of the extracellular matrix (ECM) of healing tissues, promotes the stability and function of FoxP3+ regulatory T-cells (Treg)...
  43. The Control of T Cell Development in Responses by PTEN
    Laurence A Turka; Fiscal Year: 2011
    ..In aim #2, we will use will use a foxp3-YFP-Cre transgenic mouse and Ptenflox mice to delete PTEN in the major subset of Tregs...
  44. ECM Costimulation of Immunoregulatory Pathways in Airway Inflammation
    Paul L Bollyky; Fiscal Year: 2013
    ..This immune dysregulation has been attributed to reduced numbers and function of regulatory T-cells, including FoxP3+ regulatory T-cells (Treg) and IL-10 producing TR1...
  45. Immunology of Factor IX Gene Transfer to Liver
    Roland W Herzog; Fiscal Year: 2013
    ..IX transgene product. Tolerance induction critically depended on a CD4+CD25+FoxP3+ regulatory T cell (Treg) response...
  46. Regulation of Foxp3 Function
    Andrew D Wells; Fiscal Year: 2012
    ..Recent studies in experimental models have established that Foxp3, which is a member of the forkhead family of DNA binding proteins, is necessary and sufficient for specification ..
  47. Regulatory T cells dictate immunity during persistent Salmonella infection
    Sing Sing Way; Fiscal Year: 2013
    ..studies indicate regulatory T cells (Tregs) that comprise a distinct lineage of CD4+ T cells characterized by Foxp3-expression play critical roles in dictating the balance between immune activation and bacterial persistence...
  48. CM F32 12-08-10 Resubmission
    CHRISTOPHER GARY MAYNE; Fiscal Year: 2013
    ..Among those regulatory pathways mediated by lymphocytes, Foxp3+ regulatory T (Treg) cells play a requisite role in establishing and maintaining immunological tolerance...
  49. SELF PEPTIDES BOUND TO MHC CLASS II IN T CELL SELECTION
    Alexander Y Rudensky; Fiscal Year: 2013
    Recent studies suggested that regulatory T cells (Tr) expressing transcription factor Foxp3 play a key role in keeping in check autoreactive T cells escaping negative selection in the thymus and peripheral tolerance induction...
  50. IN VIVO ROLE OF CTLA-4 IN COSTIMULATION AND AUTOIMMUNITY
    Arlene H Sharpe; Fiscal Year: 2012
    ..b>FoxP3+ CD4 regulatory T cells, the effector functions of MOG-reactive Th1 vs...
  51. Therapeutic delivery of FoxP3+ T cells to the intestine
    Chang H Kim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Project Summary: FoxP3+ regulatory T cells play critical roles in maintaining immune tolerance in the intestine...
  52. Integrin CD11b and its role in immune suppression
    Li Zhang; Fiscal Year: 2010
    ..the formation of a distinct CD4+CD25+ T regulatory (Treg) cell population that expresses the transcription factor Foxp3. Two distinct subtypes of Foxp3+ Treg cells have been identified in vivo: the naturally occurring Treg cells (..
  53. Epigenetic Regulation of Acute Lung Injury Resolution
    Benjamin Singer; Fiscal Year: 2013
    ..In Specific Aim 2, the effect of DNA methyltransferase inhibition on a critical Treg gene (Foxp3) will be determined following lung injury using chromatin immunoprecipitation and real-time PCR...
  54. T-cell mediated immunity in chlamydia genital infection
    Kathleen A Kelly; Fiscal Year: 2012
    ..We have identified CD4+FoxP3+Tregs and CD8+CXCR5+Tregs that appear in overlapping but different locations during chlamydial genital infection ..
  55. Immunization against Atherosclerosis
    Guoxing Zheng; Fiscal Year: 2012
    ..Importantly, CD4+CD25+Foxp3+ regulatory T cells (Treg), a subset of T cells that function to suppress the response of Teff, have been shown to ..
  56. Injury-Specific Activation of the Immune System
    James A Lederer; Fiscal Year: 2013
    ..in this aim will address the MHCII-dependence on Treg activation using MHCII gene deficient (MHCII-/-) mice, FoxP3-GFP gene knock-in mice, and adoptive transfer approaches...
  57. The role of ABCG1 in Atherosclerosis Progression and TH17 Differentiation
    LATEIRA DENISE HAYNES; Fiscal Year: 2013
    ..Regulatory T cells (Tregs) are a subset of T cells that express FoxP3 and suppress autoimmunity. Tregs have been reported to be antiatherogenic...
  58. Transfusion-associated immune hemolysis
    Karina Yazdanbakhsh; Fiscal Year: 2010
    ..T cells (Tregs) characterized by co- expression of CD25 and the forkhead/winged helix transcription factor(Foxp3) are key suppressors of immunopathological immune responses...
  59. Selective MicoRNA modification to enhance regulatory T cell function in IBD
    Colm Collins; Fiscal Year: 2013
    ..e. TNF[unreadable]ARE) that recapitulates many features of Crohn's disease;demonstrated expansion of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the inflamed ileum along the disease timecourse by both flow cytometry and RT-PCR...
  60. Knockdown of Gene Expression in Immune Cells in Humanized Mice
    Judy Lieberman; Fiscal Year: 2010
    ..To test the utility of the AsiC method for studying human immunity in vivo, we will design CD4-AsiCs to knockdown FOXP3 and BCL6, transcription factors that direct CD4 T cell differentiation into suppressive Treg cells and antibody-..
  61. Towards Induction of Cell Transplant Tolerance
    Lina Lu; Fiscal Year: 2013
    ..generation or accumulation of Gr-1+CD11b+CD11clow myeloid- derived suppressor cells (MDSC) and marked expansion of FoxP3+ T regulatory (Treg) cells, that lead to long term islet allograft survival...
  62. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    Abstract Background: The X-linked gene FOXP3 is a member of the forkhead-box/winged-helix transcription factor family and responsible for X-linked IPEX (Immunodysregulation, Polyendocrinopathy, and Enteropathy, Xlinked) syndrome in mice ..
  63. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  64. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..by downregulation of Th1 and Th17 cell responses against myelin antigens and upregulation of Th2 and FoxP3+ Tregs...
  65. Estrogen and Immunoprotection in Experimental Stroke
    Patricia D Hurn; Fiscal Year: 2013
    ..abnormal activation of splenic immunocytes, particularly T lymphocytes that have a regulatory phenotype (CD4+CD25+FoxP3+ Treg cells) and ordinarily provide endogenous immunosuppression...
  66. IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB
    Jeffrey A Bluestone; Fiscal Year: 2013
    ..A loss of Tregs results in a fatal autoimmune disease (termed IPEX in humans), and small changes in Treg numbers or function accompany the onset of autoimmune diseases...
  67. Immunoregulation and immunotherapy of breast cancer
    Robert H Vonderheide; Fiscal Year: 2012
    ..a single infusion of the anti-CD25 monoclonal antibody (mAb) daclizumab resulted in prolonged depletion of CD4+ Foxp3+ CD25+ Tregs in patients at a level not previously achievable...
  68. Targeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell function
    Ulf Beier; Fiscal Year: 2013
    ..The transcription factor Forkheadbox-p3 (Foxp3) plays a key role in the development and functions of Treg...
  69. Elucidation of the transcriptional network underlying the Th17 lineage program
    Dan Littman; Fiscal Year: 2013
    ..RORyt is also often co-expressed with the regulatory T (Treg) cell- specifying factor Foxp3, which restrains Th17 cell differentiation...
  70. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..PROJECT 1 Principal Investigator: Dieter Jaeger, PhD Title: The Role of Mouse Motor Thalamus Relaying Basal Ganglia Outflow Description (provided by ..
  71. Mechanisms controlling Foxp3 expression and regulatory T cell homeostasis
    Ye Zheng; Fiscal Year: 2013
    ..One of the milestones in Treg biology field was the identification of transcription factor Foxp3 as an essential regulator of Treg development and function...
  72. T lymphocyte-induced glial activation during CNS immune reconstitution disease
    James R Lokensgard; Fiscal Year: 2013
    ..We will then determine how Foxp3(+) regulatory T-cell (Treg) dysregulation contributes to CNS-IRD...
  73. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2013
    ..Specific Aim 1 is designed to examine the transcriptional regulation of FOXP3 in successful and failed induction of CD8+CCR7+ Tregs and to investigate how Rapamycin-modulated signaling ..
  74. Anti-PV1 Therapy for Pancreatic Cancer
    RADU VIRGIL STAN; Fiscal Year: 2013
    ..Accordingly, PV1 blockade results in decreases in intratumoral regulatory T cells (CD4+FoxP3+) and myeloid cells (CD11b+Gr-1+), as well as concomitant increases in CD8 and CD4 helper T cells...
  75. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..In addition, PGRN antagonizes TNF[unreadable]- mediated down-regulation of Treg suppressive function and Foxp3 expression;in vivo treatment with PGRN selectively stimulates IL-10 production in Treg cells and PGRN-stimulated ..
  76. Immune mechanisms of CAM intervention in autoimmunity
    BRIAN CALVIN ASTRY; Fiscal Year: 2013
    ..reduction of IL- 17 response is owing to an altered balance between CD4+ T helper 17 (Th17) and CD4+CD25+Foxp3+ T regulatory cells (Treg), which is influenced in part by altered processing and presentation of the disease- ..
  77. Inducible Regulatory T Cells for the Prevention and Treatment of Acute GVHD
    Margaret L Macmillan; Fiscal Year: 2013
    ..are a subset of CD4+ T cells that co-express high levels of the IL-2Ra chain (CD25) and the transcription factor, FoxP3. Adoptive transfer of natural Tregs (nTregs, CD4+CD25brFoxP3+) that arise in the thymus have already been shown to ..
  78. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..The primary end point is percentage of CD4+CD25+FOXP3+ Tregs in the peripheral blood at 6 months post-transplant...
  79. A Comparative Genomics and Transgenic Approach to Regulation of IL-10 Expression.
    Jay H Bream; Fiscal Year: 2013
    ..Il10-/- mice from LPS toxicity and colitis which was associated with hIL-10 production from macrophages and CD4+FoxP3+ Tregs respectively. Interestingly, the hIL10BAC did not restore susceptibility to persistent L...
  80. A Multidisciplinary and Translational Approach to Hepatobiliary Malignancy
    David R Nelson; Fiscal Year: 2013
    ..response to HCC, which is characterized by impaired CD response, increased populations of circulating CD4+CD25+ FoxP3 regulatory T cells (Treg) and soluble CD25...
  81. Autoimmune Encephalomyelitis And Regulatory T Cells
    Youhai H Chen; Fiscal Year: 2013
    ..The objectives of this proposal are to (i) determine how c-Rel turns on Foxp3 gene to initiate Treg cell differentiation, (ii) determine how Foxp3 terminates c-Rel activity to stabilize Treg ..
  82. Vitamin A and acquired immune privilege
    Randolph J Noelle; Fiscal Year: 2013
    ..We have identified multiple genetic models where RA signaling in T cells, CD4+ T cells and Foxp3+ T cells can be specifically manipulated in vivo to causally implicate RA-dependent T cell signaling and ..
  83. Control of Airway Tolerance
    Michael Croft; Fiscal Year: 2013
    ..We have shown in a mouse model of asthma that inhalation of pure protein antigen induces two iTreg populations, Foxp3+LAP- and Foxp3-LAP+ CD4 cells, that both can suppress Th2-driven allergic lung inflammation and protect against ..
  84. IL-2-dependent mechanisms in T1D
    Thomas R Malek; Fiscal Year: 2013
    ..However, other than induction of Foxp3 and CD25, little is known concerning the mechanisms activated in Tregs by weak IL-2R signaling...
  85. Immune regulation and co-stimulation in treatment outcome of chronic hepatitis B
    Kyong Mi Chang; Fiscal Year: 2013
    ..Based on published literature and our own preliminary data implicating immune regulatory (FoxP3+ Tregs, IL-10) and costimulatory (PD-1) pathways in chronic viral infections including HBV, we hypothesize that ..
  86. Innate/Adaptive Immune Interactions in Gut Inflammation
    Sergio A Lira; Fiscal Year: 2013
    ..In the first project the focus is on assessing the role of a newly defined population that expresses both FoxP3 and IL-17 in Crohn's disease tissues and may represent the previously undescribed interface between Tregs and ..
  87. Regulation of Th17 cells by the Fyn Tyrosine Kinase
    Paul L Stein; Fiscal Year: 2013
    ..Furthermore a higher proportion of cells express Foxp3, a marker of immunosuppressive Treg cells...
  88. Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant
    WAYNE WILLIAM contact HANCOCK; Fiscal Year: 2010
    ..We will focus on CD4+CD25+Foxp3+ T regulatory (Treg) cell function in pediatric liver and kidney transplant recipients since these cells are ..
  89. Mechanisms of Regulatory B Cell Function
    Bonnie N Dittel; Fiscal Year: 2013
    ..recently discovered that Breg control both the onset and severity of EAE by the homeostatic maintenance of CD4+Foxp3+ T regulatory cell (Treg) numbers...
  90. Lineage Specific Effects of IL10 In Autoimmunity
    Terrence L Geiger; Fiscal Year: 2013
    ..In preliminary studies, we analyzed deficiency of IL10R? on T cells, Foxp3+ regulatory T cells, B cells and macrophage in a model autoimmune disease, experimental allergic encephalomyelitis ..
  91. Novel Mechanisms of Tolerance Resistance
    Laurence A Turka; Fiscal Year: 2013
    ..Using combinations of physiologic MHC mismatched models, foxp3 reporter mice, and TCR transgenic mice which allow for cell fate tracking, we will test differential requirements ..
  92. Development and specificity of endogeneous tumor-infiltrating regulatory T cells
    PETER AIDAN SAVAGE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Foxp3+ regulatory T cels ("Tregs") are critical for the regulation of immune homeostasis, organ-specific tolerance, and inflammation...
  93. IL-2/Treg-based immunity to TB and AIDS-related TB
    Zheng W Chen; Fiscal Year: 2013
    ..We have recently shown that IL-2 treatment of macaques can induce remarkable expansion of CD4+CD25(high)Foxp3+ T regulatory cells (Treg) in systemic and respiratory sites, and more importantly confers apparent homeostatic ..
  94. VISTA, a novel checkpoint that suppresses anti-tumor T cell responses
    Li Wang; Fiscal Year: 2013
    ..2) Determine the role of VISTA on the development and function of Foxp3+CD4+ Tregs...
  95. ASTHMA CONTROL VARIABILITY DURING PREGNANCY
    TIMOTHY PARKER; Fiscal Year: 2013
    ..b>Foxp3 is the primary gene responsible for Treg regulation...
  96. ASTHMA CONTROL VARIABILITY DURING PREGNANCY
    David Lynch; Fiscal Year: 2013
    ..b>Foxp3 is the primary gene responsible for Treg regulation...
  97. Sodium Chloride Induced Dysregulation of CD4+CD25+ Regulatory T Cells in Patients
    AMANDA HERNANDEZ; Fiscal Year: 2013
    ..by applicant): Multiple sclerosis (MS) is thought to be an autoimmune disease with losses of functional CD4+FoxP3+ regulatory T cells allowing activated autoreactive T cells to initiate CNS damage...
  98. Control of Treg exhaustion by OX40
    Xian Chang Li; Fiscal Year: 2013
    ..This is a sober reminder that there remain significant barriers to graft acceptance. We recently discovered that Foxp3+ Tregs, a cell type dedicated to immune regulation and also critically involved in transplant tolerance, can be ..
  99. ApoVax104-HPV as a Novel Vaccine for Cervical Cancer
    KATHRYN MACLEOD; Fiscal Year: 2009
    ..further augmenting adaptive immunity, and most importantly iiii) overcomes the suppressive function of CD4+CD25+FoxP3+ T regulatory (Treg) cells...
  100. Importance of CD5 for the function of regulatory T cells
    Subbarao Bondada; Fiscal Year: 2009
    ..They are characterized by expression of a transcription factor Foxp3 and CD25, while being quiescent. In cell transfer models T-Regs have been shown to potently suppress IBD...
  101. Mechanisms mediating CD28 and CD154 independent rejection
    Xian Chang Li; Fiscal Year: 2010
    ..Th17 cells, which is an important tolerogenic feature in transplant models, but it also blocks the induction of Foxp3+ Tregs from na[unreadable]ve T effector cells, which is detrimental to allograft tolerance...