FOXP3

Summary

Gene Symbol: FOXP3
Description: forkhead box P3
Alias: AIID, DIETER, IPEX, JM2, PIDX, XPID, forkhead box protein P3, FOXP3delta7, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin
Species: human
Products:     FOXP3

Top Publications

  1. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan A, Stroud J, et al. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006;126:375-87 pubmed
    ..Treg) function is mediated by an analogous cooperative complex of NFAT with the forkhead transcription factor FOXP3, a lineage specification factor for Tregs...
  2. Pan F, Yu H, Dang E, Barbi J, Pan X, Grosso J, et al. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science. 2009;325:1142-6 pubmed publisher
    ..program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-..
  3. Zheng Y, Manzotti C, Burke F, Dussably L, Qureshi O, Walker L, et al. Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3. J Immunol. 2008;181:1683-91 pubmed
    ..We have examined the role of CTLA-4 and its relationship with the transcription factor FoxP3 using a model of Treg induction in human peripheral blood...
  4. Ahmadzadeh M, Antony P, Rosenberg S. IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells. J Immunother. 2007;30:294-302 pubmed
    Although FOXP3 is primarily expressed by regulatory CD4 T cells (Treg) in vivo, polyclonal activation of human CD8 T cells can result in the expression of FOXP3 in a fraction of CD8 T cells...
  5. Magg T, Mannert J, Ellwart J, Schmid I, Albert M. Subcellular localization of FOXP3 in human regulatory and nonregulatory T cells. Eur J Immunol. 2012;42:1627-38 pubmed publisher
    The transcriptional regulator FOXP3 is an important determinant of regulatory T (Treg) cell development and function and is frequently used to quantitate Treg cells...
  6. Lin Y, Lee J, Wu A, Tsai C, Yu H, Wang L, et al. Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study. Lupus. 2011;20:137-43 pubmed publisher
    b>Foxp3, encoded by the human FOXP3 gene, is a transcription factor that regulates regulatory T-cell (Treg) development and function...
  7. Zhou S, Shen Z, Wang Y, Ma H, Xu S, Qin J, et al. CCR7 expression and intratumoral FOXP3+ regulatory T cells are correlated with overall survival and lymph node metastasis in gastric cancer. PLoS ONE. 2013;8:e74430 pubmed publisher
    ..The aim of this study was to investigate the prognostic value of chemokine receptor CCR7 expression and intratumoral FOXP3(+) regulatory T cells (Tregs) in gastric cancer...
  8. Droeser R, Obermann E, Wolf A, Wallner S, Wolf D, Tzankov A. Negligible nuclear FOXP3 expression in breast cancer epithelial cells compared with FOXP3-positive T cells. Clin Breast Cancer. 2013;13:264-70 pubmed publisher
    The presence of forkhead box protein 3 (FOXP3) in breast cancer cells is a matter of debate. We systematically analyzed expression of FOXP3 in 1574 breast carcinomas...
  9. Liu J, Lluis A, Illi S, Layland L, Olek S, von Mutius E, et al. T regulatory cells in cord blood--FOXP3 demethylation as reliable quantitative marker. PLoS ONE. 2010;5:e13267 pubmed publisher
    Regulatory T-cells (Tregs), characterized as CD4+CD25(hi) T-cells expressing FOXP3, play a crucial role in controlling healthy immune development during early immune maturation...

More Information

Publications78

  1. Hanel S, Velavan T, Kremsner P, Kun J. Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population. Immunogenetics. 2011;63:409-15 pubmed publisher
    ..We identified and investigated regulatory SNPs in the promoter region of the FOXP3 gene in a group of Gabonese individuals exposed to a variety of parasitic infections...
  2. Li W, Wang L, Katoh H, Liu R, Zheng P, Liu Y. Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers. Cancer Res. 2011;71:2162-71 pubmed publisher
    ..Here we report that spontaneous mutation of the transcription factor FOXP3 reduces expression of the LATS2 gene in mammary epithelial cells...
  3. Wang F, Jing X, Li G, Wang T, Yang B, Zhu Z, et al. Foxp3+ regulatory T cells are associated with the natural history of chronic hepatitis B and poor prognosis of hepatocellular carcinoma. Liver Int. 2012;32:644-55 pubmed publisher
    ..The number of tumour-infiltrating and circulating FoxP3(+) Tregs was significantly high in patients with CHB (P < 0.001)...
  4. Wu Z, You Z, Zhang C, Li Z, Su X, Zhang X, et al. Association between functional polymorphisms of Foxp3 gene and the occurrence of unexplained recurrent spontaneous abortion in a Chinese Han population. Clin Dev Immunol. 2012;2012:896458 pubmed publisher
    ..It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells...
  5. Dimitrakopoulos F, Papadaki H, Antonacopoulou A, Kottorou A, Gotsis A, Scopa C, et al. Association of FOXP3 expression with non-small cell lung cancer. Anticancer Res. 2011;31:1677-83 pubmed
    Lung cancer is rarely cured by current therapeutic approaches. Although numerous studies have implicated FOXP3 positive regulatory T-cells in cancer pathogenesis, the role of FOXP3 in lung cancer pathogenesis remains unkown...
  6. André G, Barbosa C, Teles J, Vilarino F, Christofolini D, Bianco B. Analysis of FOXP3 polymorphisms in infertile women with and without endometriosis. Fertil Steril. 2011;95:2223-7 pubmed publisher
    To evaluate FOXP3 polymorphisms (rs3761549, rs3761548, rs2232368, rs2232366, and rs2280883) in a group of infertile women with and without endometriosis and controls. Case control study...
  7. Chen Y, Zhang H, Liao W, Zhou J, He G, Xie X, et al. FOXP3 gene polymorphism is associated with hepatitis B-related hepatocellular carcinoma in China. J Exp Clin Cancer Res. 2013;32:39 pubmed publisher
    Previous evidence has shown that the FOXP3 gene was involved in the pathogenesis of several tumors; however, the correlation between single nucleotide polymorphisms (SNPs) in the FOXP3 gene and the susceptibility to hepatitis B-related ..
  8. Kryczek I, Wu K, Zhao E, Wei S, Vatan L, Szeliga W, et al. IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer. J Immunol. 2011;186:4388-95 pubmed publisher
    b>Foxp3(+)CD4(+) regulatory T (Treg) cells inhibit immune responses and temper inflammation. IL-17(+)CD4(+) T (Th17) cells mediate inflammation of autoimmune diseases...
  9. Pesenacker A, Bending D, Ursu S, Wu Q, Nistala K, Wedderburn L. CD161 defines the subset of FoxP3+ T cells capable of producing proinflammatory cytokines. Blood. 2013;121:2647-58 pubmed publisher
    Regulatory FoxP3+CD4+ T cells (Treg) are vital for maintaining the balance between tolerance, adequate immune response, and autoimmunity...
  10. Nadeau K, McDonald Hyman C, Noth E, Pratt B, Hammond S, Balmes J, et al. Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol. 2010;126:845-852.e10 pubmed publisher
    ..Treg-cell impairment is associated with increased DNA methylation of Forkhead box transcription factor 3 (Foxp3), a key transcription factor in Treg-cell activity...
  11. Chen Z, Barbi J, Bu S, Yang H, Li Z, Gao Y, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 2013;39:272-85 pubmed publisher
    ..The key Treg cell transcription factor Foxp3 is downregulated during inflammation to allow for the acquisition of effector T cell-like functions...
  12. Ma G, Miao Q, Liu Y, Gao H, Lian J, Wang Y, et al. High FoxP3 expression in tumour cells predicts better survival in gastric cancer and its role in tumour microenvironment. Br J Cancer. 2014;110:1552-60 pubmed publisher
    Forkhead Box P3 (FoxP3) is thought to be a key transcription factor in regulatory T cells (Tregs), and recent data indicate that it is expressed in several tumour cells...
  13. Tao H, Mimura Y, Aoe K, Kobayashi S, Yamamoto H, Matsuda E, et al. Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells. Lung Cancer. 2012;75:95-101 pubmed publisher
    Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that engage in the maintenance of immunological self-tolerance and immune homeostasis...
  14. Zeng C, Yao Y, Jie W, Zhang M, Hu X, Zhao Y, et al. Up-regulation of Foxp3 participates in progression of cervical cancer. Cancer Immunol Immunother. 2013;62:481-7 pubmed publisher
    b>Foxp3 was identified as a key protein in mediating inhibitory functions of regulatory T cell (Treg)...
  15. Bovenschen H, van de Kerkhof P, van Erp P, Woestenenk R, Joosten I, Koenen H. Foxp3+ regulatory T cells of psoriasis patients easily differentiate into IL-17A-producing cells and are found in lesional skin. J Invest Dermatol. 2011;131:1853-60 pubmed publisher
    ..In addition, CD4+CD25(high) regulatory T-cell (Treg) function appeared to be impaired in psoriasis. CD4+CD25(high)Foxp3+ Tregs are typically considered inhibitors of autoimmune responses...
  16. Kim M, Koo J, Lee S. FOXP3 expression is related to high Ki-67 index and poor prognosis in lymph node-positive breast cancer patients. Oncology. 2013;85:128-36 pubmed publisher
    Recent preclinical studies have shown that Forkhead box protein 3 (FOXP3) is an important tumor suppressor gene. The clinical and prognostic implication of FOXP3 expression in breast cancer cells still remains controversial...
  17. McInnes N, Sadlon T, Brown C, Pederson S, Beyer M, Schultze J, et al. FOXP3 and FOXP3-regulated microRNAs suppress SATB1 in breast cancer cells. Oncogene. 2012;31:1045-54 pubmed publisher
    The transcription factor FOXP3 has been identified as a tumour suppressor in the breast and prostate epithelia, but little is known about its specific mechanism of action...
  18. Fodor E, Garaczi E, Polyanka H, Koreck A, Kemeny L, Szell M. The rs3761548 polymorphism of FOXP3 is a protective genetic factor against allergic rhinitis in the Hungarian female population. Hum Immunol. 2011;72:926-9 pubmed publisher
    We aimed to study whether forkhead box P3 (FOXP3) polymorphisms contribute to allergic rhinitis (AR) in a Central-European population, the Hungarians, similarly as it was found in Han Chinese...
  19. Huang Y, Liao H, Zhang Y, Yuan R, Wang F, Gao Y, et al. Prognostic value of tumor-infiltrating FoxP3+ T cells in gastrointestinal cancers: a meta analysis. PLoS ONE. 2014;9:e94376 pubmed publisher
    Tumor-infiltrating FoxP3+ T cells have been reported in various human tumors, which impaired cell-mediated immunity and promoted disease progression...
  20. Oda J, Hirata B, Guembarovski R, Watanabe M. Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases. J Genet. 2013;92:163-71 pubmed
    The FOXP3 gene encodes a transcription factor thought to be important for the development and function of regulatory T cells (Treg cells)...
  21. Inoue N, Watanabe M, Morita M, Tomizawa R, Akamizu T, Tatsumi K, et al. Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases. Clin Exp Immunol. 2010;162:402-6 pubmed publisher
    ..Forkhead box P3 (FoxP3) is a crucial regulatory factor for the development and function of regulatory T (T(reg) ) cells, and deficiency ..
  22. Zheng J, Deng J, Jiang L, Yang L, You Y, Hu M, et al. Heterozygous genetic variations of FOXP3 in Xp11.23 elevate breast cancer risk in Chinese population via skewed X-chromosome inactivation. Hum Mutat. 2013;34:619-28 pubmed publisher
    b>FOXP3 (forkhead box P3: also known as IPEX, XPID) is not only a hallmark of immunosuppressive regulatory T cells (Tregs), but also an X-linked breast cancer suppressor gene expressed in tumor cells...
  23. Fritzsching B, Haas J, König F, Kunz P, Fritzsching E, Poschl J, et al. Intracerebral human regulatory T cells: analysis of CD4+ CD25+ FOXP3+ T cells in brain lesions and cerebrospinal fluid of multiple sclerosis patients. PLoS ONE. 2011;6:e17988 pubmed publisher
    Impaired suppressive capacity of CD4(+)CD25(+)FOXP3(+) regulatory T cells (Treg) from peripheral blood of patients with multiple sclerosis (MS) has been reported by multiple laboratories...
  24. Yoshii M, Tanaka H, Ohira M, Muguruma K, Iwauchi T, Lee T, et al. Expression of Forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach. Br J Cancer. 2012;106:1668-74 pubmed publisher
    It was recently reported that the transcription factor Forkhead box P3 (FoxP3) is expressed not only in regulatory T cells (Tregs) but also in cancer cells...
  25. Sun L, Wu J, Yi S. Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response. Transpl Immunol. 2012;26:71-80 pubmed publisher
    Naturally occurring CD4+CD25+ regulatory T cells (nTregs) that express high level of Foxp3 actively suppress pathological and physiological immune responses, contributing to the maintenance of immunological self-tolerance and immune ..
  26. Suzuki H, Onishi H, Morisaki T, Tanaka M, Katano M. Intratumoral FOXP3+VEGFR2+ regulatory T cells are predictive markers for recurrence and survival in patients with colorectal cancer. Clin Immunol. 2013;146:26-33 pubmed publisher
    Previously, we have shown that CD8(+)T/FOXP3(+) cell ratio but not FOXP3(+) cell number alone is an independent prognostic factor for colorectal cancer...
  27. Kaur G, Goodall J, Jarvis L, Hill Gaston J. Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells--identification of Foxp3?7 in human regulatory T cells. Mol Immunol. 2010;48:321-32 pubmed publisher
    b>Foxp3 is proposed to play a critical role in the development and function of regulatory T cells...
  28. Nie H, Zheng Y, Li R, Guo T, He D, Fang L, et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-? in rheumatoid arthritis. Nat Med. 2013;19:322-8 pubmed publisher
    ..Here we demonstrate that forkhead box P3 (FOXP3) transcriptional activity and, consequently, Treg cell suppressive function are regulated by phosphorylation at ..
  29. Kim M, Grimmig T, Grimm M, Lazariotou M, Meier E, Rosenwald A, et al. Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. PLoS ONE. 2013;8:e53630 pubmed publisher
    Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression...
  30. Bandukwala H, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, et al. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity. 2011;34:479-91 pubmed publisher
    The transcription factor FOXP3 is essential for the suppressive function of regulatory T cells that are required for maintaining self-tolerance...
  31. Mathai A, Kapadia M, Alexander J, Kernochan L, Swanson P, Yeh M. Role of Foxp3-positive tumor-infiltrating lymphocytes in the histologic features and clinical outcomes of hepatocellular carcinoma. Am J Surg Pathol. 2012;36:980-6 pubmed publisher
    The role of Foxp3-positive regulatory T cells (Foxp3 Tregs) in suppression of antitumoral immune response is well documented in patients with cancer...
  32. Wang L, Su L, Wang J. Correlation between elevated FOXP3 expression and increased lymph node metastasis of gastric cancer. Chin Med J (Engl). 2010;123:3545-9 pubmed
    b>FOXP3 was thought to express in the T-cell lineage exclusively until recently when FOXP3 was shown to be expressed by cancer cells...
  33. Jeron A, Hansen W, Ewert F, Buer J, Geffers R, Bruder D. ChIP-on-chip analysis identifies IL-22 as direct target gene of ectopically expressed FOXP3 transcription factor in human T cells. BMC Genomics. 2012;13:705 pubmed publisher
    The transcription factor (TF) forkhead box P3 (FOXP3) is constitutively expressed at high levels in naturally occurring CD4+CD25+ regulatory T cells (nTregs)...
  34. Schadenberg A, Vastert S, Evens F, Kuis W, van Vught A, Jansen N, et al. FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human. Eur J Immunol. 2011;41:1132-42 pubmed publisher
    Tregs are crucial in controlling inflammation. Although the transcription factor FOXP3 is the most applicable phenotype marker of Tregs, it does not indisputably characterize suppressive function during T-cell activation in vitro...
  35. Ma G, Chen S, Sun Z, Miao Q, Liu Y, Zeng X, et al. FoxP3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating the apoptotic signaling pathway. Biochem Biophys Res Commun. 2013;430:804-9 pubmed publisher
    Forkhead Box Protein 3 (FoxP3) was identified as a key transcription factor to the occurring and function of the regulatory T cells (Tregs). However, limited evidence indicated its function in tumor cells...
  36. He Y, Bo Q, Yong W, Qiu Z, Li Y, Li W. FoxP3 genetic variants and risk of non-small cell lung cancer in the Chinese Han population. Gene. 2013;531:422-5 pubmed publisher
    ..The forkhead box P3 (FoxP3) gene regulates regulatory T-cell development and function and may modulate the susceptibility to non-small cell ..
  37. Himmel M, Macdonald K, Garcia R, Steiner T, Levings M. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol. 2013;190:2001-8 pubmed publisher
    b>FOXP3-expressing T regulatory cells (Tregs) can be divided into two distinct subsets: naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) that differentiate in peripheral tissues upon exposure to Ag ..
  38. Frattini V, Pisati F, Speranza M, Poliani P, Frigè G, Cantini G, et al. FOXP3, a novel glioblastoma oncosuppressor, affects proliferation and migration. Oncotarget. 2012;3:1146-57 pubmed
    The transcription factor FOXP3 plays an essential role in regulatory T cell development and function. In addition, it has recently been identified as a tumor suppressor in different cancers...
  39. Soligo M, Camperio C, Caristi S, Scotta C, Del Porto P, Costanzo A, et al. CD28 costimulation regulates FOXP3 in a RelA/NF-?B-dependent mechanism. Eur J Immunol. 2011;41:503-13 pubmed publisher
    The molecular mechanisms whereby CD28 alone or associated with TCR can regulate FOXP3 expression are not understood, although the importance of CD28 as a pivotal regulator of CD4(+) CD25(+) FOXP3(+) T cells is well recognized...
  40. Sakaki M, Makino R, Hiroishi K, Ueda K, Eguchi J, Hiraide A, et al. Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression. Hepatol Res. 2010;40:1219-26 pubmed publisher
    ..COX-2) and osteopontin (OPN) promoter regions and a promoter/enhancer region of forkhead box protein 3 (FOXP3) gene are known to affect immune responses, we examined whether these polymorphisms can influence susceptibility ..
  41. Duan W, So T, Mehta A, Choi H, Croft M. Inducible CD4+LAP+Foxp3- regulatory T cells suppress allergic inflammation. J Immunol. 2011;187:6499-507 pubmed publisher
    ..We report that inhaled soluble Ag induces adaptive Foxp3(+) Tregs, as well as a regulatory population of CD4(+) T cells in the lungs and lung-draining lymph nodes that ..
  42. Mantel P, Kuipers H, Boyman O, Rhyner C, Ouaked N, Rückert B, et al. GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol. 2007;5:e329 pubmed
    ..b>FOXP3 is an essential transcription factor for natural, thymus-derived (nTreg) and inducible Treg (iTreg) commitment; ..
  43. Heltzer M, Choi J, Ochs H, Sullivan K, Torgerson T, Ernst L. A potential screening tool for IPEX syndrome. Pediatr Dev Pathol. 2007;10:98-105 pubmed
    ..tool that allows rapid identification of patients with IPEX syndrome using immunocytochemical staining of FOXP3+ cells in bowel biopsies...
  44. Merlo A, Casalini P, Carcangiu M, Malventano C, Triulzi T, Menard S, et al. FOXP3 expression and overall survival in breast cancer. J Clin Oncol. 2009;27:1746-52 pubmed publisher
    The transcription factor forkhead box P3 (FOXP3) up- or downregulates a large number of genes and has been recently reported to be expressed in tumor cells...
  45. Passerini L, Allan S, Battaglia M, Di Nunzio S, Alstad A, Levings M, et al. STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. Int Immunol. 2008;20:421-31 pubmed publisher
    Forkhead box P3 (FOXP3) is considered a specific marker for CD4(+)CD25(+) regulatory T (Treg) cells, but increasing evidence suggests that human CD4(+)CD25(-) effector T (Teff) cells can transiently express FOXP3 upon activation...
  46. Bourreau E, Ronet C, Darcissac E, Lise M, Sainte Marie D, Clity E, et al. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infect Immun. 2009;77:1465-74 pubmed publisher
    The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL)...
  47. Voo K, Wang Y, Santori F, Boggiano C, Wang Y, Arima K, et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A. 2009;106:4793-8 pubmed publisher
    ..In this study, we report that human peripheral blood and lymphoid tissue contain a significant number of CD4(+)FOXP3(+) T cells that express CCR6 and have the capacity to produce IL-17 upon activation...
  48. Hoffmann P, Boeld T, Eder R, Huehn J, Floess S, Wieczorek G, et al. Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol. 2009;39:1088-97 pubmed publisher
    ..activated conventional T cells from natural Treg cell populations allowing the isolation of highly enriched FOXP3(+) cells with all functional and molecular characteristics of natural Treg...
  49. Rouas R, Fayyad Kazan H, El Zein N, Lewalle P, Rothé F, Simion A, et al. Human natural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression. Eur J Immunol. 2009;39:1608-18 pubmed publisher
    ..We identified a functional target sequence for miR-31 in the 3' untranslated region (3' UTR) of FOXP3 mRNA...
  50. Yapici U, Bemelman F, Scheepstra C, Roelofs J, Claessen N, van der Loos C, et al. Intragraft FOXP3 protein or mRNA during acute renal allograft rejection correlates with inflammation, fibrosis, and poor renal outcome. Transplantation. 2009;87:1377-80 pubmed publisher
    Forkhead box (FOXP3) is considered to be a specific marker for regulatory T cells...
  51. Berbic M, Hey Cunningham A, Ng C, Tokushige N, Ganewatta S, Markham R, et al. The role of Foxp3+ regulatory T-cells in endometriosis: a potential controlling mechanism for a complex, chronic immunological condition. Hum Reprod. 2010;25:900-7 pubmed publisher
    ..Surprisingly, Foxp3+ regulatory T-cells, which control and suppress a range of immune responses, have not previously been investigated ..
  52. Brunkow M, Jeffery E, Hjerrild K, Paeper B, Clark L, Yasayko S, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73 pubmed
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.
  53. Frey D, Droeser R, Viehl C, Zlobec I, Lugli A, Zingg U, et al. High frequency of tumor-infiltrating FOXP3(+) regulatory T cells predicts improved survival in mismatch repair-proficient colorectal cancer patients. Int J Cancer. 2010;126:2635-43 pubmed publisher
    ..The transcription factor forkhead box P3 (FOXP3) is an intracellular key molecule for T(reg) development and function and is considered to represent the most ..
  54. Kmieciak M, Gowda M, Graham L, Godder K, Bear H, Marincola F, et al. Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function. J Transl Med. 2009;7:89 pubmed publisher
    b>Foxp3 has been suggested to be a standard marker for murine Tregs whereas its role as marker for human Tregs is controversial...
  55. Mailer R, Falk K, Rotzschke O. Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity. PLoS ONE. 2009;4:e6104 pubmed publisher
    Phenotype and function of regulatory T cells (Treg) largely depend on the presence of the transcription factor FOXP3. In contrast to mice, human Treg cells express isoforms of this protein...
  56. Ebert L, Tan B, Browning J, Svobodova S, Russell S, Kirkpatrick N, et al. The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res. 2008;68:3001-9 pubmed publisher
    b>FoxP3 is a member of the forkhead family of transcription factors critically involved in the development and function of CD25(+) regulatory T cells (Treg)...
  57. Gavin M, Torgerson T, Houston E, deRoos P, Ho W, Stray Pedersen A, et al. Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development. Proc Natl Acad Sci U S A. 2006;103:6659-64 pubmed
    Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the genetic program governing CD25+CD4+ regulatory T cell (T(R)) development and function in mice...
  58. Bassuny W, Ihara K, Sasaki Y, Kuromaru R, Kohno H, Matsuura N, et al. A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes. Immunogenetics. 2003;55:149-156 pubmed publisher
    FOXP3/Scurfin, a member of forkhead/winged-helix proteins, is involved in the regulation of T-cell activation, and essential for normal immune homeostasis. The FOXP3/Scurfin gene is located on chromosome Xp11...
  59. Mantel P, Ouaked N, Rückert B, Karagiannidis C, Welz R, Blaser K, et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol. 2006;176:3593-602 pubmed
    b>FOXP3 is playing an essential role for T regulatory cells and is involved in the molecular mechanisms controlling immune tolerance...
  60. Yuan X, Chen L, Li M, Dong P, Xue J, Wang J, et al. Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner. Clin Immunol. 2010;134:277-88 pubmed publisher
    The transcription factor Foxp3 plays a key role in CD4(+)CD25(+) regulatory T (Treg) cell function. A correlation has been shown between survival and the frequency of tumor-infiltrating Foxp3-positive Treg cells in cancer patients...
  61. Chatila T, Blaeser F, Ho N, Lederman H, Voulgaropoulos C, Helms C, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest. 2000;106:R75-81 pubmed
    ..Using a positional-candidate approach, we have identified in both kindreds mutations in JM2, a gene on Xp11.23 that encodes a fork head domain-containing protein...
  62. Fuchizawa T, Adachi Y, Ito Y, Higashiyama H, Kanegane H, Futatani T, et al. Developmental changes of FOXP3-expressing CD4+CD25+ regulatory T cells and their impairment in patients with FOXP3 gene mutations. Clin Immunol. 2007;125:237-46 pubmed
    b>FOXP3 is required for the generation and function of CD4(+)CD25(+) regulatory T (Treg) cells...
  63. Karanikas V, Speletas M, Zamanakou M, Kalala F, Loules G, Kerenidi T, et al. Foxp3 expression in human cancer cells. J Transl Med. 2008;6:19 pubmed publisher
    Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs)...
  64. Ouaked N, Mantel P, Bassin C, Burgler S, Siegmund K, Akdis C, et al. Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1. J Immunol. 2009;182:1041-9 pubmed
    ..The master regulator of T regulatory cell differentiation, the transcription factor FOXP3, is required for both their development and function...
  65. Provoost S, Maes T, van Durme Y, Gevaert P, Bachert C, Schmidt Weber C, et al. Decreased FOXP3 protein expression in patients with asthma. Allergy. 2009;64:1539-46 pubmed publisher
    ..In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma...
  66. Matsumoto K, Inoue H, Fukuyama S, Kan O K, Eguchi Tsuda M, Matsumoto T, et al. Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma. Respirology. 2009;14:187-94 pubmed publisher
    A forkhead/winged-helix family transcriptional repressor, Foxp3, is highly expressed on CD4(+)CD25(+) T regulatory cells. The role of Foxp3(+)CD4(+)CD25(+) T regulatory cells in asthma remains to be elucidated...
  67. Grant C, Oh U, Fugo K, Takenouchi N, Griffith C, Yao K, et al. Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways. PLoS Pathog. 2006;2:e33 pubmed
    Forkhead box (Fox)/winged-helix transcription factors regulate multiple aspects of immune responsiveness and Foxp3 is recognized as an essential functional marker of regulatory T cells...
  68. Olivito B, Simonini G, Ciullini S, Moriondo M, Betti L, Gambineri E, et al. Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis. J Rheumatol. 2009;36:2017-24 pubmed publisher
    To investigate the relationship between interleukin 17 (IL-17) producing T cells (Th17) and CD4+CD25+FOXP3+ regulatory T cells (Tregs) in blood and synovial fluid (SF) of patients with juvenile idiopathic arthritis (JIA)...
  69. Fantini M, Becker C, Monteleone G, Pallone F, Galle P, Neurath M. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol. 2004;172:5149-53 pubmed
    ..In the present work, we demonstrate that TGF-beta is able to induce Foxp3 expression and subsequently a regulatory phenotype in CD4(+)CD25(-) peripheral murine T cells...