FOXP3

Summary

Gene Symbol: FOXP3
Description: forkhead box P3
Alias: AIID, DIETER, IPEX, PIDX, XPID, FOXP3delta7, forkhead box protein P3, immune dysregulation, polyendocrinopathy, enteropathy, X-linked, immunodeficiency, polyendocrinopathy, enteropathy, X-linked, scurfin
Species: human

Top Publications

  1. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
  2. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
  3. ncbi FOXP3 controls regulatory T cell function through cooperation with NFAT
    Yongqing Wu
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 126:375-87. 2006
  4. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
  5. ncbi The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    C L Bennett
    Division of Genetics and Development, Department of Pediatrics, University of Washington, Seattle, USA
    Nat Genet 27:20-1. 2001
  6. ncbi Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
  7. doi FOXP3 expression and overall survival in breast cancer
    Andrea Merlo
    Molecular Biology Unit, Department of Experimental Oncology, Pathology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori and the Institute of Pathology, University of Milan, Milan, Italy
    J Clin Oncol 27:1746-52. 2009
  8. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
  9. doi Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy
    Sylvain Ladoire
    Department of Medical Oncology, Centre Regional de Lutte Contre Cancer Georges François Leclerc, Dijon, France
    Breast Cancer Res Treat 125:65-72. 2011
  10. ncbi DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    Udo Baron
    Epiontis GmbH, Berlin, Germany
    Eur J Immunol 37:2378-89. 2007

Detail Information

Publications223 found, 100 shown here

  1. pmc FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
    Qi Jiang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, USA
    Blood 112:2858-68. 2008
    The role of FoxP3(+)CD4(+) regulatory T (Treg) cells in HIV-1 disease in vivo is poorly understood due to the lack of a robust model...
  2. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
    ..This finding firmly establishes the role of IFIH1 in T1D and demonstrates that resequencing studies can pinpoint disease-causing genes in genomic regions initially identified by GWASs...
  3. ncbi FOXP3 controls regulatory T cell function through cooperation with NFAT
    Yongqing Wu
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    Cell 126:375-87. 2006
    ..Treg) function is mediated by an analogous cooperative complex of NFAT with the forkhead transcription factor FOXP3, a lineage specification factor for Tregs...
  4. pmc TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function
    Liang Zhou
    The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, New York 10016, USA
    Nature 453:236-40. 2008
    ..but depends on distinct transcription factors: RORgammat (encoded by Rorc(gammat)) for T(H)17 cells and Foxp3 for T(reg) cells...
  5. ncbi The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    C L Bennett
    Division of Genetics and Development, Department of Pediatrics, University of Washington, Seattle, USA
    Nat Genet 27:20-1. 2001
    ..We present genetic evidence that different mutations of the human gene FOXP3, the ortholog of the gene mutated in scurfy mice (Foxp3), causes IPEX syndrome...
  6. ncbi Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
    The forkhead transcription factor Foxp3 is highly expressed in CD4+CD25+ regulatory T cells (Treg) and was recently identified as a key player in mediating their inhibitory functions...
  7. doi FOXP3 expression and overall survival in breast cancer
    Andrea Merlo
    Molecular Biology Unit, Department of Experimental Oncology, Pathology Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori and the Institute of Pathology, University of Milan, Milan, Italy
    J Clin Oncol 27:1746-52. 2009
    The transcription factor forkhead box P3 (FOXP3) up- or downregulates a large number of genes and has been recently reported to be expressed in tumor cells...
  8. pmc Identification of IL-17-producing FOXP3+ regulatory T cells in humans
    Kui Shin Voo
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:4793-8. 2009
    ..In this study, we report that human peripheral blood and lymphoid tissue contain a significant number of CD4(+)FOXP3(+) T cells that express CCR6 and have the capacity to produce IL-17 upon activation...
  9. doi Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy
    Sylvain Ladoire
    Department of Medical Oncology, Centre Regional de Lutte Contre Cancer Georges François Leclerc, Dijon, France
    Breast Cancer Res Treat 125:65-72. 2011
    ..We investigated the prognostic significance of Foxp3 expression in cancer cells in a large cohort of patients with HER2-overexpressing breast carcinoma treated with ..
  10. ncbi DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells
    Udo Baron
    Epiontis GmbH, Berlin, Germany
    Eur J Immunol 37:2378-89. 2007
    The transcription factor FOXP3 is critical for development and function of regulatory T cells (Treg)...
  11. ncbi Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis
    Valerie Guyot-Revol
    Tuberculosis Immunology Group, Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Level 7, Oxford OX3 9DU, UK
    Am J Respir Crit Care Med 173:803-10. 2006
    ..CD4+CD25(high) regulatory T cells mediate suppressed cellular immunity in several chronic infections but have not been described in TB...
  12. pmc Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors
    Katy Milne
    Trev and Joyce Deeley Research Centre, BC Cancer Agency, Victoria, British Columbia, Canada
    PLoS ONE 4:e6412. 2009
    ..Tumor-infiltrating T cells are associated with survival in epithelial ovarian cancer (EOC), but their functional status is poorly understood, especially relative to the different risk categories and histological subtypes of EOC...
  13. ncbi In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma
    Marc Beyer
    Molecular Tumor Biology and Tumor Immunology, Clinic I for Internal Medicine, University of Cologne, Joseph Stelzmann Strasse 9 Haus 16, 50931 Cologne, Germany
    Blood 107:3940-9. 2006
    ..premalignant monoclonal gammopathy of undetermined significance and patients with multiple myeloma that functional FoxP3(+) T(reg) cells of naive, central, and effector memory phenotype as determined by CCR7 and CD45RA expression are ..
  14. ncbi X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    R S Wildin
    Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland, USA
    Nat Genet 27:18-20. 2001
    ..We found four non-polymorphic mutations. Each mutation affects the forkhead/winged-helix domain of the scurfin protein, indicating that the mutations may disrupt critical DNA interactions.
  15. ncbi FOXP3 ensembles in T-cell regulation
    Bin Li
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 6082, USA
    Immunol Rev 212:99-113. 2006
    Our recent studies have identified dynamic protein ensembles containing forkhead box protein 3 (FOXP3) that provide insight into the molecular complexity of suppressor T-cell activities, and it is our goal to determine how these ..
  16. pmc Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
    Maha Ayyoub
    Institut National de la Sante et de la Recherche Medicale, Unite 892, Centre Rene Gauducheau, 44800 Saint Herblain, France
    Proc Natl Acad Sci U S A 106:8635-40. 2009
    Recent studies have suggested a close relationship between CD4(+)FOXP3(+) regulatory T cells (Tregs) and proinflammatory IL-17-producing T helper cells (T(H)17) expressing the lineage-specific transcription factor RORgamma t...
  17. ncbi Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    M E Brunkow
    Celltech Chiroscience, Inc, Bothell, Washington, USA
    Nat Genet 27:68-73. 2001
    ..In sf mice, a frameshift mutation results in a product lacking the forkhead domain. Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.
  18. pmc Defective regulatory and effector T cell functions in patients with FOXP3 mutations
    Rosa Bacchetta
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Milan, Italy
    J Clin Invest 116:1713-22. 2006
    ..immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is caused by mutations in the forkhead box protein P3 (FOXP3) gene...
  19. pmc IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    Emmanuel Zorn
    Division of Hematologic Malignancies, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    Blood 108:1571-9. 2006
    IL-2 plays a critical role in the maintenance of CD4+CD25+ FOXP3(+) regulatory T cells (Tregs) in vivo. We examined the effects of IL-2 signaling in human Tregs...
  20. pmc FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
    Bin Li
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, 36th and Hamilton Walk, Philadelphia, PA 19104 6082, USA
    Proc Natl Acad Sci U S A 104:4571-6. 2007
    The forkhead family protein FOXP3 acts as a repressor of transcription and is both an essential and sufficient regulator of the development and function of regulatory T cells...
  21. doi Prognostic potential of FOXP3 expression in non-small cell lung cancer cells combined with tumor-infiltrating regulatory T cells
    Hiroyuki Tao
    Department of Thoracic Surgery, NHO Yamaguchi Ube Medical Center, 685 Higashi Kiwa, Ube, 755 0241, Japan
    Lung Cancer 75:95-101. 2012
    Expression of the transcription factor FOXP3 characterizes regulatory T cells (Tregs) that engage in the maintenance of immunological self-tolerance and immune homeostasis...
  22. doi Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy
    Nicolette Moes
    Universite Paris Descartes, Paris, France
    Gastroenterology 139:770-8. 2010
    ..AIE has been associated with mutations in FOXP3-a transcription factor that controls regulatory T-cell development and function...
  23. pmc Domain requirements and sequence specificity of DNA binding for the forkhead transcription factor FOXP3
    Kian Peng Koh
    Department of Pathology, Harvard Medical School and Immune Disease Institute, Boston, Massachusetts, United States of America
    PLoS ONE 4:e8109. 2009
    The forkhead, winged-helix transcription factor FOXP3 is preferentially expressed in T regulatory (Treg) cells and is critical for their immunosuppressive function...
  24. ncbi Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, 2660 Oak Street, Vancouver, Canada
    Int Immunol 19:345-54. 2007
    Forkhead box P3 (FOXP3) is currently thought to be the most specific marker for naturally occurring CD4(+)CD25(+) T regulatory cells (nTregs)...
  25. doi Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner
    Xiang Liang Yuan
    Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, China
    Clin Immunol 134:277-88. 2010
    The transcription factor Foxp3 plays a key role in CD4(+)CD25(+) regulatory T (Treg) cell function. A correlation has been shown between survival and the frequency of tumor-infiltrating Foxp3-positive Treg cells in cancer patients...
  26. ncbi STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells
    Laura Passerini
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Via Olgettina 58, 20132 Milan, Italy
    Int Immunol 20:421-31. 2008
    Forkhead box P3 (FOXP3) is considered a specific marker for CD4(+)CD25(+) regulatory T (Treg) cells, but increasing evidence suggests that human CD4(+)CD25(-) effector T (Teff) cells can transiently express FOXP3 upon activation...
  27. pmc Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    Roopali Gandhi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:846-53. 2010
    ..We found that AhR activation promoted the differentiation of CD4(+)Foxp3(-) T cells, which produce IL-10 and control responder T cells through granzyme B...
  28. pmc FOXP3 promoter demethylation reveals the committed Treg population in humans
    Peter C J Janson
    Department of Medicine, Clinical Allergy Research Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 3:e1612. 2008
    ..The transcription factor FOXP3 is crucial for the suppressive activity of Tregs and is considered the most specific marker for this population...
  29. pmc Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer
    Aaron S Mansfield
    Breast Surgery Unit, Helsinki University Central Hospital, Helsinki, Finland
    BMC Cancer 9:231. 2009
    ..Our aim was to assess whether expression of Foxp3, a marker of Tregs, and IDO were linked with nodal metastasis in breast cancer patients...
  30. ncbi Clinical and molecular profile of a new series of patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: inconsistent correlation between forkhead box protein 3 expression and disease severity
    Eleonora Gambineri
    Department of Pediatrics, Anna Meyer University Children s Hospital, University of Florence, Florence, Italy
    J Allergy Clin Immunol 122:1105-1112.e1. 2008
    Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is an autoimmune genetic disorder caused by mutation of the forkhead box protein 3 gene (FOXP3), a key regulator of immune tolerance.
  31. pmc FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2
    Tao Zuo
    Department of Surgery, Section of General Surgery, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 117:3765-73. 2007
    ..We recently demonstrated that forkhead box P3 (FOXP3) is an X-linked breast cancer suppressor and an important repressor of the oncogene ERBB2/HER2...
  32. pmc Acquisition of suppressive function by activated human CD4+ CD25- T cells is associated with the expression of CTLA-4 not FoxP3
    Yong Zheng
    Division of Immunity and Infection, Medical Research Council Centre for Immune Regulation, Institute of Biomedical Research, University of Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 181:1683-91. 2008
    ..We have examined the role of CTLA-4 and its relationship with the transcription factor FoxP3 using a model of Treg induction in human peripheral blood...
  33. pmc Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis
    E Bourreau
    Immunologie des Leishmanioses, Institut Pasteur de la Guyane, 97306 Cayenne, French Guyana
    Infect Immun 77:1465-74. 2009
    The levels of regulatory T cells (Treg cells), analyzed by Foxp3 mRNA expression, were determined in lesions from patients with acute cutaneous leishmaniasis (ACL) and chronic cutaneous leishmaniasis (CCL)...
  34. doi Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    Jorg van Loosdregt
    Molecular Immunology Lab, Department of Immunology, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Blood 115:965-74. 2010
    ..Expression levels of the transcription factor Foxp3 have been causally associated with Treg differentiation and function...
  35. pmc Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells
    Fan Pan
    Immunology and Hematopoiesis Division, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Science 325:1142-6. 2009
    ..program of Tregs and their ability to suppress pathologic immune responses depends on the transcription factor Foxp3. Despite progress in understanding mechanisms of Foxp3-dependent gene activation, the molecular mechanism of Foxp3-..
  36. pmc FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus
    Runhua Liu
    Division of Immunotherapy and Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, Michigan, USA
    Cancer Res 69:2252-9. 2009
    ..Here, we report that X-linked tumor suppressor FOXP3 is essential for p21 expression in normal epithelia and that lack of FOXP3 is associated with p21 down-regulation ..
  37. doi Decreased FOXP3 protein expression in patients with asthma
    S Provoost
    Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
    Allergy 64:1539-46. 2009
    ..In this study, we aimed to evaluate circulating T(reg), defined by the protein FOXP3, in both control subjects and patients with stable asthma.
  38. pmc Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells
    Mindi R Walker
    Diabetes Program, Benaroya Research Institute, 1201 Ninth Avenue, Seattle, Washington 98101, USA
    J Clin Invest 112:1437-43. 2003
    ..Recently, the forkhead/winged helix transcription factor, FoxP3, has been shown to be important for the function of TR cells in mice...
  39. doi Cyclooxygenase-2 gene promoter polymorphisms affect susceptibility to hepatitis C virus infection and disease progression
    Masashi Sakaki
    Division of Gastroenterology, Department of Medicine Clinical Research Laboratory, Showa University School of Medicine, Tokyo, Japan
    Hepatol Res 40:1219-26. 2010
    ..COX-2) and osteopontin (OPN) promoter regions and a promoter/enhancer region of forkhead box protein 3 (FOXP3) gene are known to affect immune responses, we examined whether these polymorphisms can influence susceptibility ..
  40. doi Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer
    Hai Yan Zhang
    The Hospital of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, PR China
    Cancer Lett 287:91-7. 2010
    The transcription factor Forkhead Box P3 (Foxp3) has been shown to play important roles in the occurring of regulatory T cells (Tregs)...
  41. doi Increased CTLA-4 and FOXP3 transcripts in peripheral blood mononuclear cells of patients with breast cancer
    Mansooreh Jaberipour
    Cancer Gene Therapy Laboratory, Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran
    Pathol Oncol Res 16:547-51. 2010
    ..These cells express Forkhead/winged helix transcription factor (FOXP3) and also Cytotoxic T-lymphocyte antigen-4 (CTLA-4), as a negative regulatory molecule which, is a potential ..
  42. ncbi Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    Masahiro Ono
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Nature 446:685-9. 2007
    ..T(R) cells specifically express the transcription factor Foxp3, a key regulator of T(R)-cell development and function...
  43. pmc Absence of leucine zipper in the natural FOXP3Delta2Delta7 isoform does not affect dimerization but abrogates suppressive capacity
    Reiner K W Mailer
    Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    PLoS ONE 4:e6104. 2009
    Phenotype and function of regulatory T cells (Treg) largely depend on the presence of the transcription factor FOXP3. In contrast to mice, human Treg cells express isoforms of this protein...
  44. doi Association of single-nucleotide polymorphisms in FOXP3 gene with systemic lupus erythematosus susceptibility: a case-control study
    Y C Lin
    Department of Pediatrics, Lotung Poh Ai Hospital, Taiwan
    Lupus 20:137-43. 2011
    b>Foxp3, encoded by the human FOXP3 gene, is a transcription factor that regulates regulatory T-cell (Treg) development and function...
  45. doi Analysis of FOXP3 polymorphisms in infertile women with and without endometriosis
    Gustavo M André
    Division of Pathological Gynecology and Human Reproduction, Department of Gynecology and Obstetrics, Faculdade de Medicina do ABC, Santo Andre, Brazil
    Fertil Steril 95:2223-7. 2011
    To evaluate FOXP3 polymorphisms (rs3761549, rs3761548, rs2232368, rs2232366, and rs2280883) in a group of infertile women with and without endometriosis and controls.
  46. doi Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma
    W Y Kim
    Department of Pathology, Seoul National University Hospital, Seoul, Korea
    Ann Oncol 20:1688-96. 2009
    ..Recently, tumor microenvironment including regulatory T cells (Tregs) has been implicated as a prognostic marker in certain types of lymphoma...
  47. doi FOXP3+ CD4+ Tregs lose suppressive potential but remain anergic during transient inflammation in human
    Alvin W L Schadenberg
    Department of Pediatric Immunology, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Immunol 41:1132-42. 2011
    Tregs are crucial in controlling inflammation. Although the transcription factor FOXP3 is the most applicable phenotype marker of Tregs, it does not indisputably characterize suppressive function during T-cell activation in vitro...
  48. doi Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance
    M I Vargas-Rojas
    Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
    Lupus 17:289-94. 2008
    ..In the present work, we quantified CD4+FOXP3+ Treg cells in patients with SLE and found no quantitative alterations...
  49. pmc Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate
    Lizhong Wang
    Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Cancer Center, Ann Arbor, MI 48109, USA
    Cancer Cell 16:336-46. 2009
    ..Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in human prostate cancer...
  50. ncbi Number of CD4+ cells and location of forkhead box protein P3-positive cells in diagnostic follicular lymphoma tissue microarrays correlates with outcome
    Abigail M Lee
    Cancer Research UK, Medical Oncology Unit, St Bartholomew s Hospital, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Clin Oncol 24:5052-9. 2006
    ..To examine the immune microenvironment in diagnostic follicular lymphoma (FL) biopsies and evaluate its prognostic significance...
  51. ncbi The expression of the regulatory T cell-specific forkhead box transcription factor FoxP3 is associated with poor prognosis in ovarian cancer
    Dominik Wolf
    Division of Hematology and Oncology, Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    Clin Cancer Res 11:8326-31. 2005
    The forkhead box transcription factor FoxP3 is specifically expressed in T cells with regulatory properties (Treg). Recently, high numbers of Treg were described to be associated with poor survival in different malignancies...
  52. doi Frequency of Foxp3+CD4CD25+ T cells is associated with the phenotypes of allergic asthma
    Koichiro Matsumoto
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Respirology 14:187-94. 2009
    A forkhead/winged-helix family transcriptional repressor, Foxp3, is highly expressed on CD4(+)CD25(+) T regulatory cells. The role of Foxp3(+)CD4(+)CD25(+) T regulatory cells in asthma remains to be elucidated...
  53. doi Novel and functional regulatory SNPs in the promoter region of FOXP3 gene in a Gabonese population
    Susanne A Hanel
    Institute for Tropical Medicine, University of Tubingen, Wilhelmstrasse 27, 72074 Tubingen, Germany
    Immunogenetics 63:409-15. 2011
    ..We identified and investigated regulatory SNPs in the promoter region of the FOXP3 gene in a group of Gabonese individuals exposed to a variety of parasitic infections...
  54. pmc Preservation of FoxP3+ regulatory T cells in the peripheral blood of human immunodeficiency virus type 1-infected elite suppressors correlates with low CD4+ T-cell activation
    Amanda J Chase
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Virol 82:8307-15. 2008
    ..data suggest that both direct infection by HIV-1 and tissue redistribution are possible explanations for declining FoxP3(+) Tregs in progressive HIV-1 infection...
  55. ncbi High numbers of tumor-infiltrating FOXP3-positive regulatory T cells are associated with improved overall survival in follicular lymphoma
    Joaquim Carreras
    Hematopathology Section, Department of Pathology, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Blood 108:2957-64. 2006
    ..To determine the impact of FOXP3-positive regulatory T cells (Tregs) in the progression and outcome of FL patients, we examined samples from 97 ..
  56. pmc FOXP3+ Tregs and B7-H1+/PD-1+ T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients: Implication for immunotherapy
    Hazem Ghebeh
    Tumor Immunology Section, King Faisal Specialist Hospital and Research Center, P, O, Box 3354, Riyadh 11211, Saudi Arabia
    BMC Cancer 8:57. 2008
    Recent studies have demonstrated a direct involvement of B7-H1, PD-1 and FOXP3 molecules in the immune escape of cancer...
  57. pmc Novel mutations of FOXP3 in two Japanese patients with immune dysregulation, polyendocrinopathy, enteropathy, X linked syndrome (IPEX)
    I Kobayashi
    J Med Genet 38:874-6. 2001
  58. doi The rs3761548 polymorphism of FOXP3 is a protective genetic factor against allergic rhinitis in the Hungarian female population
    Eszter Fodor
    Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary
    Hum Immunol 72:926-9. 2011
    We aimed to study whether forkhead box P3 (FOXP3) polymorphisms contribute to allergic rhinitis (AR) in a Central-European population, the Hungarians, similarly as it was found in Han Chinese...
  59. ncbi Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome
    Catherine J Owen
    Institute of Human Genetics and Department of Child Health, University of Newcastle upon Tyne, United Kingdom
    J Clin Endocrinol Metab 88:6034-9. 2003
    ..The disease gene, FOXP3, was identified in 2001, and several mutations within this gene have since been described in patients with IPEX...
  60. doi Characterisation of Foxp3 splice variants in human CD4+ and CD8+ T cells--identification of Foxp3Δ7 in human regulatory T cells
    Gurman Kaur
    Department of Medicine, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 0QQ, United Kingdom
    Mol Immunol 48:321-32. 2010
    b>Foxp3 is proposed to play a critical role in the development and function of regulatory T cells...
  61. ncbi A potential screening tool for IPEX syndrome
    Meredith Lee Heltzer
    Division of Allergy and Immunology, Department of Pediatrics, University of Pennsylvania School of Medicine, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Dev Pathol 10:98-105. 2007
    ..tool that allows rapid identification of patients with IPEX syndrome using immunocytochemical staining of FOXP3+ cells in bowel biopsies...
  62. pmc Association between functional polymorphisms of Foxp3 gene and the occurrence of unexplained recurrent spontaneous abortion in a Chinese Han population
    Zaigui Wu
    Department of Obstetrics and Gynecology, the First Affiliated Hospital of Medical College, Sun Yat Sen University, Guangzhou, Guangdong, China
    Clin Dev Immunol 2012:896458. 2012
    ..It is well known that Forkhead box P3 (Foxp3) is a crucial regulatory factor for the development and function of Treg cells...
  63. pmc Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
    Barbara Ensoli
    National AIDS Center, Istituto Superiore di Sanita, Rome, Italy
    PLoS ONE 5:e13540. 2010
    ..In contrast, these changes were opposite, absent or partial in the OBS population. These findings support the use of Tat immunization to intensify HAART efficacy and to restore immune homeostasis...
  64. pmc Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome
    Laura Passerini
    San Raffaele Telethon Institute for Gene Therapy HSR TIGET, Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute, Milan, Italy
    Eur J Immunol 41:1120-31. 2011
    Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, ..
  65. doi Diverse foxp3 expression in children with type 1 diabetes and celiac disease
    Anna Kivling
    Division of Pediatrics and Diabetes Research Center, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Ann N Y Acad Sci 1150:273-7. 2008
    ..The mRNA expression of the Treg-associated marker FOXP3 was analyzed with multiplex real-time RT-PCR. Children with T1D showed both a low spontaneous (P < 0...
  66. doi Th17 transcription factor RORC2 is inversely correlated with FOXP3 expression in the joints of children with juvenile idiopathic arthritis
    Biagio Olivito
    Department of Paediatrics, Rheumatology and Immunology Unit, University of Florence, Anna Meyer Children s Hospital, Florence, Italy
    J Rheumatol 36:2017-24. 2009
    To investigate the relationship between interleukin 17 (IL-17) producing T cells (Th17) and CD4+CD25+FOXP3+ regulatory T cells (Tregs) in blood and synovial fluid (SF) of patients with juvenile idiopathic arthritis (JIA).
  67. pmc Rapid temporal control of Foxp3 protein degradation by sirtuin-1
    Jorg van Loosdregt
    Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e19047. 2011
    Maintenance of Foxp3 protein expression in regulatory T cells (Treg) is crucial for a balanced immune response...
  68. ncbi Genetic association study of FOXP3 polymorphisms in allergic rhinitis in a Chinese population
    Luo Zhang
    Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education of China, Beijing Institute of Otorhinolaryngology, Beijing 100005, People s Republic of China
    Hum Immunol 70:930-4. 2009
    The FOXP3 gene encodes a transcription factor thought to be essential for the development and function of regulatory T cells, which are prevailing mediators of immunological tolerance via suppression/modulation of both T helper (Th)-1 ..
  69. doi Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis
    Yasunori Ito
    Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Ann Allergy Asthma Immunol 103:160-5. 2009
    b>FOXP3-positive CD4+CD25+ T cells are known to have an immunoregulatory function by means of preventing T-cell reactivity to both self- and non-self-antigens...
  70. ncbi No association between variation of the FOXP3 gene and common type 1 diabetes in the Sardinian population
    Patrizia Zavattari
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Ospedale Microcitemico, Cagliari, Italy
    Diabetes 53:1911-4. 2004
    Mutations of the forkhead/winged helix transcription factor FOXP3 gene on chromosome Xp11...
  71. ncbi Adult T-cell leukemia/lymphoma cells from blood and skin tumors express cytotoxic T lymphocyte-associated antigen-4 and Foxp3 but lack suppressor activity toward autologous CD8+ T cells
    Takatoshi Shimauchi
    Department of Dermatology, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyusyu 807 8555, Japan
    Cancer Sci 99:98-106. 2008
    ..the expression of the Treg-associated molecule cytotoxic T lymphocyte-associated antigen (CTLA)-4 and Foxp3 was examined in freshly isolated circulating and skin-infiltrating tumor cells from 21 ATL patients with skin ..
  72. doi Genome-wide identification of human FOXP3 target genes in natural regulatory T cells
    Timothy J Sadlon
    Molecular Immunology Laboratory, Women s and Children s Health Research Institute, Women s and Children s Hospital, North Adelaide, South Australia, Australia
    J Immunol 185:1071-81. 2010
    The transcription factor FOXP3 is essential for the formation and function of regulatory T cells (Tregs), and Tregs are essential for maintaining immune homeostasis and tolerance...
  73. pmc Association of functional polymorphisms related to the transcriptional level of FOXP3 with prognosis of autoimmune thyroid diseases
    N Inoue
    Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Yamadaoka 1 7 Suita, Osaka, Japan
    Clin Exp Immunol 162:402-6. 2010
    ..Forkhead box P3 (FoxP3) is a crucial regulatory factor for the development and function of regulatory T (T(reg) ) cells, and deficiency ..
  74. pmc Foxp3 expression in human cancer cells
    Vaios Karanikas
    Cancer Immunology Unit, Department of Immunology and Histocompatibility, School of Medicine, University of Thessaly, University Hospital of Larissa, GR 411 10 Larissa, Greece
    J Transl Med 6:19. 2008
    Transcription factor forkhead box protein 3 (Foxp3) specifically characterizes the thymically derived naturally occurring regulatory T cells (Tregs)...
  75. pmc FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene
    Tao Zuo
    Program in Molecular, Cellular, and Developmental Biology and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, OH 43210, USA
    Cell 129:1275-86. 2007
    ..Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate...
  76. pmc Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development
    Marc A Gavin
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 103:6659-64. 2006
    Forkhead winged-helix transcription factor Foxp3 serves as the dedicated mediator of the genetic program governing CD25+CD4+ regulatory T cell (T(R)) development and function in mice...
  77. ncbi Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    L A Schubert
    Immunology Program, Virginia Mason Research Center, Seattle, Washington 98101, USA
    J Biol Chem 276:37672-9. 2001
    ..in these mice and in humans with mutations in the orthologous gene indicates that the foxp3 gene product, scurfin, is involved in the regulation of T cell activation and differentiation...
  78. pmc Foxp3 represses retroviral transcription by targeting both NF-kappaB and CREB pathways
    Christian Grant
    Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Pathog 2:e33. 2006
    Forkhead box (Fox)/winged-helix transcription factors regulate multiple aspects of immune responsiveness and Foxp3 is recognized as an essential functional marker of regulatory T cells...
  79. ncbi Secondary progressive in contrast to relapsing-remitting multiple sclerosis patients show a normal CD4+CD25+ regulatory T-cell function and FOXP3 expression
    Koen Venken
    Biomedisch Onderzoeksinstituut and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt University, Diepenbeek, Belgium
    J Neurosci Res 83:1432-46. 2006
    ..Consistently with the suppressive capacity, CD4(+)CD25(+) T cells from SP-MS patients showed normal levels of FOXP3 mRNA in contrast to RR-MS patients that had a reduced FOXP3 expression...
  80. pmc Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects
    S Alice Long
    Benaroya Research Institute at Virginia Mason, Seattle, Washington, USA
    Diabetes 59:407-15. 2010
    ..However, no link between IL-2 responsiveness and CD4(+)CD25(+)FOXP3(+) regulatory T-cells (Tregs) has been demonstrated in type 1 diabetic subjects despite the role of these IL-2-..
  81. pmc Effects of natalizumab treatment on Foxp3+ T regulatory cells
    Max Philipp Stenner
    Department of Neurology, Julius Maximilians University, Wuerzburg, Germany
    PLoS ONE 3:e3319. 2008
    ..Our objective was to study impacts of Natalizumab therapy on Foxp3+ T regulatory cells (Tregs) in multiple sclerosis (MS) patients.
  82. ncbi Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    Haruhiko Yagi
    Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Int Immunol 16:1643-56. 2004
    ..Recent studies with mice showed that Foxp3, which encodes the transcription factor Scurfin, is a master regulatory gene for the development and function of CD25(+)CD4(+) regulatory T cells...
  83. ncbi FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis
    Noritoshi Kobayashi
    Pathology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, and Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan
    Clin Cancer Res 13:902-11. 2007
    Tumor-infiltrating lymphocytes represent the host immune response to cancer. CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress the immune reaction...
  84. doi Malignant Tregs express low molecular splice forms of FOXP3 in Sézary syndrome
    T Krejsgaard
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Leukemia 22:2230-9. 2008
    ..Here, we study the regulatory T cell (Treg) function and the expression of FOXP3 in SS. We demonstrate that malignant T cells in 8 of 15 patients stain positive with an anti-FOXP3 antibody...
  85. ncbi Regulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1
    Nadia Ouaked
    Swiss Institute of Allergy and Asthma Research Davos, affiliated with the University of Zurich, Davos Platz, Switzerland
    J Immunol 182:1041-9. 2009
    ..The master regulator of T regulatory cell differentiation, the transcription factor FOXP3, is required for both their development and function...
  86. ncbi Phenotypic and functional analysis of CD4+ CD25- Foxp3+ T cells in patients with systemic lupus erythematosus
    Michael Bonelli
    Division of Rheumatology, Internal Medicine III, General Hospital of Vienna, Medical University of Vienna, Vienna, Austria
    J Immunol 182:1689-95. 2009
    CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) that specialize in the suppression of immune responses might be critically involved in the pathogenesis of autoimmune diseases...
  87. doi Intragraft FOXP3 protein or mRNA during acute renal allograft rejection correlates with inflammation, fibrosis, and poor renal outcome
    Unsal Yapici
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Transplantation 87:1377-80. 2009
    Forkhead box (FOXP3) is considered to be a specific marker for regulatory T cells...
  88. pmc IL-2 and IL-15 each mediate de novo induction of FOXP3 expression in human tumor antigen-specific CD8 T cells
    Mojgan Ahmadzadeh
    Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunother 30:294-302. 2007
    Although FOXP3 is primarily expressed by regulatory CD4 T cells (Treg) in vivo, polyclonal activation of human CD8 T cells can result in the expression of FOXP3 in a fraction of CD8 T cells...
  89. ncbi Paucity of FOXP3+ cells in skin and peripheral blood distinguishes Sézary syndrome from other cutaneous T-cell lymphomas
    C D Klemke
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Leukemia 20:1123-9. 2006
    ..In this study, we investigated cutaneous expression of the regulatory T-cell (T(reg)) marker FOXP3 in 30 CTCL patients...
  90. doi Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes
    Srinath Sanda
    Benaroya Research Institute and the University of Washington School of Medicine, 1201 9th Avenue, Seattle, WA 98101, USA
    Clin Immunol 127:138-43. 2008
    ..Newly diagnosed children had higher levels of FoxP3 expression in CD4 CD25 double positive cells (56.1%+/-24.9 vs. 24.9%+/-24.6 p=0...
  91. ncbi Isoform-specific inhibition of ROR alpha-mediated transcriptional activation by human FOXP3
    Jianguang Du
    Immunology Program, Benaroya Research Institute, Seattle, WA 98101, USA
    J Immunol 180:4785-92. 2008
    b>FOXP3 is a forkhead family transcriptional repressor important for the development and function of CD4(+)CD25(+) regulatory T cells. In humans, FOXP3 is expressed as two isoforms, a full-length form and a smaller form lacking exon 2...
  92. ncbi Molecular mechanisms underlying FOXP3 induction in human T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research, Obere Str 22, CH 7270 Davos, Switzerland
    J Immunol 176:3593-602. 2006
    b>FOXP3 is playing an essential role for T regulatory cells and is involved in the molecular mechanisms controlling immune tolerance...
  93. pmc The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
    Sarah E Allan
    Department of Surgery, University of British Columbia, and Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada
    J Clin Invest 115:3276-84. 2005
    ..Recently, it was shown that the transcription factor FOXP3 is necessary and sufficient for the generation of CD4+ CD25+ Tregs in mice...
  94. doi Foxp3 expression on normal and leukemic CD4+CD25+ T cells implicated in human T-cell leukemia virus type-1 is inconsistent with Treg cells
    Masaki Abe
    Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Eur J Haematol 81:209-17. 2008
    b>Foxp3 is a master gene of Treg cells, a novel subset of CD4(+) T cells primarily expressing CD25...
  95. ncbi No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
    Todd Brusko
    Department of Pathology, College of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0275, USA
    Diabetes 56:604-12. 2007
    ..investigations by the addition of a more lineage-specific marker for Tregs, transcription factor forkhead box P3 (FOXP3), in subjects with type 1 diabetes, their first-degree relatives, and healthy control subjects...
  96. ncbi The regulation of Foxp3 expression in regulatory CD4(+)CD25(+)T cells: multiple pathways on the road
    Lianjun Zhang
    Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
    J Cell Physiol 211:590-7. 2007
    ..b>Foxp3, a recently identified member of the forkhead transcription factors, serves as a master regulator for the ..
  97. ncbi IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression
    Alessandra Fragale
    Department of Infectious, Parasitic and Immunomediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Immunol 181:1673-82. 2008
    ..report that IRF-1 negatively regulates CD4(+)CD25(+) Treg cell development and function by specifically repressing Foxp3 expression...
  98. ncbi CD4+ CD25+ FoxP3+ T-cell infiltration and heme oxygenase-1 expression correlate with tumor grade in human gliomas
    Abdeljabar El Andaloussi
    Division of Neurosurgery, The University of Chicago, MC 3026, Chicago, IL, 60637, USA
    J Neurooncol 83:145-52. 2007
    ..in heme catabolism, has also been shown to accumulate during glioma progression and to play a critical role in FoxP3 mediated immune suppression...
  99. pmc JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    T A Chatila
    Department of Pediatrics, and Department of Pathology and Immunology and the Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 106:R75-81. 2000
    ..The other mutation involves an in-frame, 3-bp deletion that is predicted to impair the function of a leucine zipper dimerization domain. Our results point to a critical role for JM2 in self tolerance and Th cell differentiation...
  100. ncbi Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells
    Jun Wang
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Immunol 37:129-38. 2007
    b>Foxp3 plays a key role in CD4+ CD25+ T(reg) cell function in mice and represents a specific marker for these cells...
  101. ncbi A functional polymorphism in the promoter/enhancer region of the FOXP3/Scurfin gene associated with type 1 diabetes
    Wafaa M Bassuny
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582, Fukuoka, Japan
    Immunogenetics 55:149-56. 2003
    FOXP3/Scurfin, a member of forkhead/winged-helix proteins, is involved in the regulation of T-cell activation, and essential for normal immune homeostasis. The FOXP3/Scurfin gene is located on chromosome Xp11...

Research Grants128 found, 100 shown here

  1. TREATMENT OF AUTOIMMUNITY WITH REGULATORY T LYMPHOCYTES
    Terrence L Geiger; Fiscal Year: 2010
    ..cells can be modulated by different forms of regulatory T lymphocytes (Treg), most prominently Treg expressing the Foxp3 transcription factor...
  2. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  3. Epigenetic Regulation of Acute Lung Injury Resolution
    Benjamin Singer; Fiscal Year: 2013
    ..In Specific Aim 2, the effect of DNA methyltransferase inhibition on a critical Treg gene (Foxp3) will be determined following lung injury using chromatin immunoprecipitation and real-time PCR...
  4. Role of natural indoles in experimental autoimmune encephalomyelitis
    Mitzi Nagarkatti; Fiscal Year: 2013
    ..by downregulation of Th1 and Th17 cell responses against myelin antigens and upregulation of Th2 and FoxP3+ Tregs...
  5. AhR activation in Th17 and Treg cell differentiation
    Liang Zhou; Fiscal Year: 2013
    ..ROR?t and Foxp3 have been shown to be the key transcription factors in specifying differentiation programs of Th17 and Treg ..
  6. Elucidation of the transcriptional network underlying the Th17 lineage program
    Dan Littman; Fiscal Year: 2013
    ..RORyt is also often co-expressed with the regulatory T (Treg) cell- specifying factor Foxp3, which restrains Th17 cell differentiation...
  7. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2012
    ..PROJECT 1 Principal Investigator: Dieter Jaeger, PhD Title: The Role of Mouse Motor Thalamus Relaying Basal Ganglia Outflow Description (provided by ..
  8. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..PROJECT 1 Principal Investigator: Dieter Jaeger, PhD Title: The Role of Mouse Motor Thalamus Relaying Basal Ganglia Outflow Description (provided by ..
  9. Selective MicoRNA modification to enhance regulatory T cell function in IBD
    Colm Collins; Fiscal Year: 2013
    ..e. TNF[unreadable]ARE) that recapitulates many features of Crohn's disease;demonstrated expansion of CD4+CD25+Foxp3+ regulatory T cells (Tregs) in the inflamed ileum along the disease timecourse by both flow cytometry and RT-PCR...
  10. Mechanisms controlling Foxp3 expression and regulatory T cell homeostasis
    Ye Zheng; Fiscal Year: 2013
    ..One of the milestones in Treg biology field was the identification of transcription factor Foxp3 as an essential regulator of Treg development and function...
  11. Consequences of Aging on Immune Response and Transplant Outcome
    STEFAN GUNTHER TULLIUS; Fiscal Year: 2013
    ..At the same time, we observed a well preserved suppressor function of old alloantigen-specific CD4+CD25+FoxP3+ T cells...
  12. T lymphocyte-induced glial activation during CNS immune reconstitution disease
    James R Lokensgard; Fiscal Year: 2013
    ..We will then determine how Foxp3(+) regulatory T-cell (Treg) dysregulation contributes to CNS-IRD...
  13. Intestinal Antigen Presenting Cells and Mucosal Immunity
    Timothy L Denning; Fiscal Year: 2013
    ..that steady state CX3CR1-expressing LP macrophages are major producers of IL-10 and are adept at promoting Foxp3+ Treg cell differentiation in an IL-10- and retinoic acid-dependent manner...
  14. Therapeutic Immunoregulation Mediated by TGF-beta-induced iTregs in Autoimmune Ar
    Song Guo Zheng; Fiscal Year: 2013
    ..nTreg or iTregs will be sorted or induced from DBA/1 Foxp3-GFP knock-in mice or Foxp3-GFP/IL-17-RFP double knock-in mice...
  15. CD8 T Cells in Rheumatoid Arthritis
    Cornelia M Weyand; Fiscal Year: 2013
    ..Specific Aim 1 is designed to examine the transcriptional regulation of FOXP3 in successful and failed induction of CD8+CCR7+ Tregs and to investigate how Rapamycin-modulated signaling ..
  16. Anti-PV1 Therapy for Pancreatic Cancer
    RADU VIRGIL STAN; Fiscal Year: 2013
    ..Accordingly, PV1 blockade results in decreases in intratumoral regulatory T cells (CD4+FoxP3+) and myeloid cells (CD11b+Gr-1+), as well as concomitant increases in CD8 and CD4 helper T cells...
  17. Understanding Protective Immunoregulatory Mechanisms in the Infant Lung
    Prabir Ray; Fiscal Year: 2013
    ..Our preliminary data show the presence of Tregs co- expressing Foxp3 and GATA-3 in RSV infected lungs, which is attenuated in IL-4R-deficient mice...
  18. Progranulin Intervention in Inflammatory Bowel Diseases
    Chuanju Liu; Fiscal Year: 2013
    ..In addition, PGRN antagonizes TNF[unreadable]- mediated down-regulation of Treg suppressive function and Foxp3 expression;in vivo treatment with PGRN selectively stimulates IL-10 production in Treg cells and PGRN-stimulated ..
  19. Immune mechanisms of CAM intervention in autoimmunity
    BRIAN CALVIN ASTRY; Fiscal Year: 2013
    ..reduction of IL- 17 response is owing to an altered balance between CD4+ T helper 17 (Th17) and CD4+CD25+Foxp3+ T regulatory cells (Treg), which is influenced in part by altered processing and presentation of the disease- ..
  20. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2010
    ..of Treg have been identified, the best characterized ones, including subsets that express the transcription factor Foxp3, and ones that produce IL-10, will be studied in the proposed experiments...
  21. Induction and maintenance of regulatory T cells
    Mitchell Kronenberg; Fiscal Year: 2013
    ..of Treg have been identified, the best characterized ones, including subsets that express the transcription factor Foxp3, and ones that produce IL-10, will be studied in the proposed experiments...
  22. Reconstitution of Regulatory T Cells After Stem Cell Transplantation
    ROBERT JON SOIFFER; Fiscal Year: 2013
    ..Expanded Treg express FoxP3 and retain functional suppressive activity...
  23. Inducible Regulatory T Cells for the Prevention and Treatment of Acute GVHD
    Margaret L Macmillan; Fiscal Year: 2013
    ..are a subset of CD4+ T cells that co-express high levels of the IL-2Ra chain (CD25) and the transcription factor, FoxP3. Adoptive transfer of natural Tregs (nTregs, CD4+CD25brFoxP3+) that arise in the thymus have already been shown to ..
  24. Novel Therapies to Improve Renal and Cardiac Allograft Outcomes
    Anil Chandraker; Fiscal Year: 2013
    ..The primary end point is percentage of CD4+CD25+FOXP3+ Tregs in the peripheral blood at 6 months post-transplant...
  25. A Comparative Genomics and Transgenic Approach to Regulation of IL-10 Expression.
    Jay H Bream; Fiscal Year: 2013
    ..Il10-/- mice from LPS toxicity and colitis which was associated with hIL-10 production from macrophages and CD4+FoxP3+ Tregs respectively. Interestingly, the hIL10BAC did not restore susceptibility to persistent L...
  26. A Multidisciplinary and Translational Approach to Hepatobiliary Malignancy
    David R Nelson; Fiscal Year: 2013
    ..response to HCC, which is characterized by impaired CD response, increased populations of circulating CD4+CD25+ FoxP3 regulatory T cells (Treg) and soluble CD25...
  27. Autoimmune Encephalomyelitis And Regulatory T Cells
    Youhai H Chen; Fiscal Year: 2013
    ..The objectives of this proposal are to (i) determine how c-Rel turns on Foxp3 gene to initiate Treg cell differentiation, (ii) determine how Foxp3 terminates c-Rel activity to stabilize Treg ..
  28. Control of Airway Tolerance
    Michael Croft; Fiscal Year: 2013
    ..We have shown in a mouse model of asthma that inhalation of pure protein antigen induces two iTreg populations, Foxp3+LAP- and Foxp3-LAP+ CD4 cells, that both can suppress Th2-driven allergic lung inflammation and protect against ..
  29. Vitamin A and acquired immune privilege
    Randolph J Noelle; Fiscal Year: 2013
    ..We have identified multiple genetic models where RA signaling in T cells, CD4+ T cells and Foxp3+ T cells can be specifically manipulated in vivo to causally implicate RA-dependent T cell signaling and ..
  30. Engineering DNA nanoparticles to create immune tolerance
    ANDREW LEE MELLOR; Fiscal Year: 2013
    ..IDO, and DCs expressing IDO suppress T cell responses, in part by stabilizing the default regulatory phenotypes of Foxp3-lineage CD4 T cells (Tregs). Thus reagents that induce IDO and activate Tregs may ameliorate autoimmune diseases...
  31. Extracellular matrix and the function and stability of FoxP3+ regulatory T-cells
    Paul L Bollyky; Fiscal Year: 2013
    ..a component of the extracellular matrix (ECM) of injured and healing tissues, in the function and stability of Foxp3+ regulatory T-cells (Treg), a T-cell subset critical to the maintenance of immune tolerance...
  32. The immunobiology of CD4+ CD25+ T regulatory cells
    Thomas R Malek; Fiscal Year: 2011
    ..these issues we propose the following specific aims:1) To further characterize the relevance of TCR diversity in Foxp3+ regulatory T cells by evaluating the efficacy and durability of Treg cells with limited diversity to suppress ..
  33. IL-2-dependent mechanisms in T1D
    Thomas R Malek; Fiscal Year: 2013
    ..However, other than induction of Foxp3 and CD25, little is known concerning the mechanisms activated in Tregs by weak IL-2R signaling...
  34. TLR2 and the Tubercle Granuloma
    Padmini Salgame; Fiscal Year: 2013
    ..The infected lungs of TLR2KO mice exhibited enhanced inflammation associated with reduced infiltration of FoxP3[+] T regulatory cells (Tregs) into the lung, while lungs from infected WT animals had resolved their inflammation ..
  35. Immune regulation and co-stimulation in treatment outcome of chronic hepatitis B
    Kyong Mi Chang; Fiscal Year: 2013
    ..Based on published literature and our own preliminary data implicating immune regulatory (FoxP3+ Tregs, IL-10) and costimulatory (PD-1) pathways in chronic viral infections including HBV, we hypothesize that ..
  36. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2010
    ..PROJECT 1 Principal Investigator: Dieter Jaeger, PhD Title: The Role of Mouse Motor Thalamus Relaying Basal Ganglia Outflow Description (provided by ..
  37. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2009
    ..Perhaps more importantly, CD4+ iNKT cells preferentially express FOXP3 (the focus of Project 3) and secrete an as of yet to be identified factor that induces myeloid DC differentiation...
  38. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2009
    ..Perhaps more importantly, CD4+ iNKT cells preferentially express FOXP3 (the focus of Project 3) and secrete an as of yet to be identified factor that induces myeloid DC differentiation...
  39. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2007
    ..Perhaps more importantly, CD4+ iNKT cells preferentially express FOXP3 (the focus of Project 3) and secrete an as of yet to be identified factor that induces myeloid DC differentiation...
  40. Reversal of CMV-specific immune deficits in patients with glioblastoma
    Duane Anthony Mitchell; Fiscal Year: 2013
    ..in vitro using pp65 RNA pulsed DCs coupled with addition of exogenous IL-2 or through the removal of CD4+CD25+FOXP3+ regulatory T cells (Tregs) prior to stimulation...
  41. Innate/Adaptive Immune Interactions in Gut Inflammation
    Lloyd F Mayer; Fiscal Year: 2012
    ..In the first project the focus is on assessing the role of a newly defined population that expresses both FoxP3 and IL-17 in Crohn's disease tissues and may represent the previously undescribed interface between Tregs and ..
  42. BCL11B in Immune Regulation
    Dorina Avram; Fiscal Year: 2013
    ..The transcriptio factor Foxp3 is crucial for Treg cell development and function, and mutations at the Foxp3 locus cause lymphoproliferative ..
  43. Innate/Adaptive Immune Interactions in Gut Inflammation
    Sergio A Lira; Fiscal Year: 2013
    ..In the first project the focus is on assessing the role of a newly defined population that expresses both FoxP3 and IL-17 in Crohn's disease tissues and may represent the previously undescribed interface between Tregs and ..
  44. Regulation of Th17 cells by the Fyn Tyrosine Kinase
    Paul L Stein; Fiscal Year: 2013
    ..Furthermore a higher proportion of cells express Foxp3, a marker of immunosuppressive Treg cells...
  45. Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant
    WAYNE WILLIAM contact HANCOCK; Fiscal Year: 2010
    ..We will focus on CD4+CD25+Foxp3+ T regulatory (Treg) cell function in pediatric liver and kidney transplant recipients since these cells are ..
  46. Calcineurin Inhibitor Minimization And Foxp3+ Tregs Post-Transplant
    Wayne Hancock; Fiscal Year: 2009
    ..We will focus on CD4+CD25+Foxp3+ T regulatory (Treg) cell function in pediatric liver and kidney transplant recipients since these cells are ..
  47. Mechanisms of Regulatory B Cell Function
    Bonnie N Dittel; Fiscal Year: 2013
    ..recently discovered that Breg control both the onset and severity of EAE by the homeostatic maintenance of CD4+Foxp3+ T regulatory cell (Treg) numbers...
  48. ECM Costimulation of Immunoregulatory Pathways in Airway Inflammation
    Paul L Bollyky; Fiscal Year: 2013
    ..This immune dysregulation has been attributed to reduced numbers and function of regulatory T-cells, including FoxP3+ regulatory T-cells (Treg) and IL-10 producing TR1...
  49. Characterization of Human Regulatory T cell-induced Dendritic Cells
    MICHAEL ALONSO; Fiscal Year: 2010
    CD4+CD25+Foxp3+ T regulatory cells (Tregs) and dendritic cells (DCs) are central to the immunosuppressive environment characteristic of many types of cancer including breast cancer...
  50. Characterization of Human Regulatory T cell-induced Dendritic Cells
    MICHAEL ALONSO; Fiscal Year: 2009
    CD4+CD25+Foxp3+ T regulatory cells (Tregs) and dendritic cells (DCs) are central to the immunosuppressive environment characteristic of many types of cancer including breast cancer...
  51. Lineage Specific Effects of IL10 In Autoimmunity
    Terrence L Geiger; Fiscal Year: 2013
    ..In preliminary studies, we analyzed deficiency of IL10R? on T cells, Foxp3+ regulatory T cells, B cells and macrophage in a model autoimmune disease, experimental allergic encephalomyelitis ..
  52. Novel Mechanisms of Tolerance Resistance
    Laurence A Turka; Fiscal Year: 2013
    ..Using combinations of physiologic MHC mismatched models, foxp3 reporter mice, and TCR transgenic mice which allow for cell fate tracking, we will test differential requirements ..
  53. Development and specificity of endogeneous tumor-infiltrating regulatory T cells
    PETER AIDAN SAVAGE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Foxp3+ regulatory T cels ("Tregs") are critical for the regulation of immune homeostasis, organ-specific tolerance, and inflammation...
  54. IL-2/Treg-based immunity to TB and AIDS-related TB
    Zheng W Chen; Fiscal Year: 2013
    ..We have recently shown that IL-2 treatment of macaques can induce remarkable expansion of CD4+CD25(high)Foxp3+ T regulatory cells (Treg) in systemic and respiratory sites, and more importantly confers apparent homeostatic ..
  55. VISTA, a novel checkpoint that suppresses anti-tumor T cell responses
    Li Wang; Fiscal Year: 2013
    ..2) Determine the role of VISTA on the development and function of Foxp3+CD4+ Tregs...
  56. Regulatory T cells dictate immunity during persistent Salmonella infection
    Sing Sing Way; Fiscal Year: 2012
    ..studies indicate regulatory T cells (Tregs) that comprise a distinct lineage of CD4+ T cells characterized by Foxp3-expression play critical roles in dictating the balance between immune activation and bacterial persistence...
  57. Sodium Chloride Induced Dysregulation of CD4+CD25+ Regulatory T Cells in Patients
    AMANDA HERNANDEZ; Fiscal Year: 2013
    ..by applicant): Multiple sclerosis (MS) is thought to be an autoimmune disease with losses of functional CD4+FoxP3+ regulatory T cells allowing activated autoreactive T cells to initiate CNS damage...
  58. ASTHMA CONTROL VARIABILITY DURING PREGNANCY
    TIMOTHY PARKER; Fiscal Year: 2013
    ..b>Foxp3 is the primary gene responsible for Treg regulation...
  59. ASTHMA CONTROL VARIABILITY DURING PREGNANCY
    David Lynch; Fiscal Year: 2013
    ..b>Foxp3 is the primary gene responsible for Treg regulation...
  60. TREATMENT OF AUTOIMMUNITY WITH REGULATORY T LYMPHOCYTES
    Terrence L Geiger; Fiscal Year: 2013
    ..cells can be modulated by different forms of regulatory T lymphocytes (Treg), most prominently Treg expressing the Foxp3 transcription factor...
  61. TREATMENT OF AUTOIMMUNITY WITH REGULATORY T LYMPHOCYTES
    Terrence Geiger; Fiscal Year: 2009
    ..cells can be modulated by different forms of regulatory T lymphocytes (Treg), most prominently Treg expressing the Foxp3 transcription factor...
  62. Control of Treg exhaustion by OX40
    Xian Chang Li; Fiscal Year: 2013
    ..This is a sober reminder that there remain significant barriers to graft acceptance. We recently discovered that Foxp3+ Tregs, a cell type dedicated to immune regulation and also critically involved in transplant tolerance, can be ..
  63. ApoVax104-HPV as a Novel Vaccine for Cervical Cancer
    KATHRYN MACLEOD; Fiscal Year: 2009
    ..further augmenting adaptive immunity, and most importantly iiii) overcomes the suppressive function of CD4+CD25+FoxP3+ T regulatory (Treg) cells...
  64. Expansion of alloantigen reactive Tregs for transplantation tolerance
    Nagendra Singh; Fiscal Year: 2010
    A small subset of T lymphocytes expresses FoxP3 and is called as regulatory T cells or Tregs. Transplantation of various organs is often required to treat many human diseases or disease-related complications...
  65. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2009
    ..Interleukin-17 (IL-17)-producing T helper 17 (Th17) cells and forkhead box P3 (FOXP3)-positive regulatory T cells (hereafter called FOXP3+ Treg) play major roles in autoimmunity and inflammation...
  66. Studying the effects of vitamin D on FOXP3 and IL-17 expression in human CD4+ T c
    Insoo Kang; Fiscal Year: 2010
    ..Interleukin-17 (IL-17)-producing T helper 17 (Th17) cells and forkhead box P3 (FOXP3)-positive regulatory T cells (hereafter called FOXP3+ Treg) play major roles in autoimmunity and inflammation...
  67. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2013
    ..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
  68. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
    ..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
  69. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    DAVID WILLIAM SCOTT; Fiscal Year: 2010
    ..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
  70. Immunotherapy for Chronic Myelogenous Leukemia
    Emmanuel Katsanis; Fiscal Year: 2009
    ..vivo and in vitro, and (2) determine whether these drugs influence the conversion CD4+CD25- T cells into CD4+CD25+FoxP3+ Treg. 2. Determine the molecular mechanisms underlying BCR-ABL tyrosine kinase inhibitor suppression of Treg...
  71. Immunotherapy for Chronic Myelogenous Leukemia
    Emmanuel Katsanis; Fiscal Year: 2010
    ..vivo and in vitro, and (2) determine whether these drugs influence the conversion CD4+CD25- T cells into CD4+CD25+FoxP3+ Treg. 2. Determine the molecular mechanisms underlying BCR-ABL tyrosine kinase inhibitor suppression of Treg...
  72. GENE THERAPEUTIC APPROACH FOR TOLERANCE INDUCTION
    David Scott; Fiscal Year: 2009
    ..Importantly, we found that CD25+, FoxP3+ regulatory T cells were required for both the induction and maintenance of tolerance in this system...
  73. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2012
    Abstract Background: The X-linked gene FOXP3 is a member of the forkhead-box/winged-helix transcription factor family and responsible for X-linked IPEX (Immunodysregulation, Polyendocrinopathy, and Enteropathy, Xlinked) syndrome in mice ..
  74. Regulatory T cells in American Tegumentary Leishmaniasis
    Alejandro Llanos; Fiscal Year: 2010
    ..is conditioned by T-regulatory cells (Tregs), a special subset of CD4+ lymphocytes, which express CD25 and FoxP3 as observed in murine models, where Tregs role in suppressing immunity against Leishmania infection has been well ..
  75. Regulatory T cells in American Tegumentary Leishmaniasis
    Alejandro Llanos; Fiscal Year: 2009
    ..is conditioned by T-regulatory cells (Tregs), a special subset of CD4+ lymphocytes, which express CD25 and FoxP3 as observed in murine models, where Tregs role in suppressing immunity against Leishmania infection has been well ..
  76. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2011
    ..Also, stronger immunoreactivity of Foxp3, IL-10 and CD25 with preponderance of CD4? T cells in carotid plaques of asymptomatic than symptomatic patients...
  77. APOPTOSIS OF SMOOTH MUSCLE CELLS IN CAROTID PLAQUES
    Devendra K Agrawal; Fiscal Year: 2010
    ..Also, stronger immunoreactivity of Foxp3, IL-10 and CD25 with preponderance of CD4? T cells in carotid plaques of asymptomatic than symptomatic patients...
  78. Analyzing The Joint Susceptibility Genes for Autoimmune Thyroiditis and Diabetes
    Yaron Tomer; Fiscal Year: 2009
    ..Specific Aim 2: To dissect the mechanisms by which CTLA-4 & FOXP3 variants predispose to APS3v: (1) CTLA-4: we will test whether a 3'UTR microsatellite predisposes to APS3v by ..
  79. T Cell Tolerance & Autoimmunity to Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2010
    ..these T cells depends on the level of antigen presentation in the recipients and that the in vivo cues promoting Foxp3+ regulatory T cells in this system differ from those previously described...
  80. Immunoregulation and immunotherapy of breast cancer
    Robert Vonderheide; Fiscal Year: 2009
    ..a single infusion of the anti-CD25 monoclonal antibody (mAb) daclizumab resulted in prolonged depletion of CD4+ Foxp3+ CD25+ Tregs in patients at a level not previously achievable...
  81. T Cell Tolerance & Autoimmunity to Nuclear Antigen La
    A Darise Farris; Fiscal Year: 2009
    ..these T cells depends on the level of antigen presentation in the recipients and that the in vivo cues promoting Foxp3+ regulatory T cells in this system differ from those previously described...
  82. Immunoregulation and immunotherapy of breast cancer
    Robert H Vonderheide; Fiscal Year: 2010
    ..a single infusion of the anti-CD25 monoclonal antibody (mAb) daclizumab resulted in prolonged depletion of CD4+ Foxp3+ CD25+ Tregs in patients at a level not previously achievable...
  83. Tolerance Through Induction of Regulatory T Cells
    David Rothstein; Fiscal Year: 2006
    ..Moreover, CTLA-4 upregulation is accompanied by induction of Foxp3, a transcription factor key for Treg development...
  84. Therapeutic immunoregulation mediated by TGF-??-induced iTregs in autoimmune arth
    Song Guo Zheng; Fiscal Year: 2010
    ..nTreg or iTregs will be sorted or induced from DBA/1 Foxp3-GFP knock-in mice or Foxp3-GFP/IL-17-RFP double knock-in mice...
  85. Regulatory T cells in B cell lymphoma
    Hyam Levitsky; Fiscal Year: 2009
    ..Although several cell types are capable of suppressing tumor-specific immunity, a subset of CD4+CD25+foxp3+ T cells appears to be among the most potent inhibitors of immune effector function...
  86. Regulatory T cells in B cell lymphoma
    HYAM ISAAC LEVITSKY; Fiscal Year: 2010
    ..Although several cell types are capable of suppressing tumor-specific immunity, a subset of CD4+CD25+foxp3+ T cells appears to be among the most potent inhibitors of immune effector function...
  87. CD4+CD25+ Treg cells regulate microglia and provide neuroprotection in ALS
    Weihua Zhao; Fiscal Year: 2010
    ..Moreover, CD4+CD25+Foxp3+ Treg cells expanded during slower disease progression phase of disease...
  88. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2010
    ..dysregulation and systemic autoimmunity because the obligatory function of this cytokine is to maintain CD4+ CD25+ FoxP3+ regulatory T-lymphocytes (Treg)...
  89. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    KAREN COATS; Fiscal Year: 2009
    ..cells will be identified in placental sections by immunofluorescent labeling with antibodies to CD4, CD25, and FoxP3. Confocal microscopy will be used to quantify these cells...
  90. Interleukin-2 and autoimmune disease
    ABUL ABBAS; Fiscal Year: 2009
    ..dysregulation and systemic autoimmunity because the obligatory function of this cytokine is to maintain CD4+ CD25+ FoxP3+ regulatory T-lymphocytes (Treg)...
  91. Interleukin-2 and autoimmune disease
    Abul K Abbas; Fiscal Year: 2011
    ..dysregulation and systemic autoimmunity because the obligatory function of this cytokine is to maintain CD4+ CD25+ FoxP3+ regulatory T-lymphocytes (Treg)...
  92. Placental Treg Activation and Pregnancy Outcome in the FIV-infected Cat Model
    GREGORY TODD PHARR; Fiscal Year: 2010
    ..cells will be identified in placental sections by immunofluorescent labeling with antibodies to CD4, CD25, and FoxP3. Confocal microscopy will be used to quantify these cells...
  93. Analyzing The Joint Susceptibility Genes for Autoimmune Thyroiditis and Diabetes
    Yaron Tomer; Fiscal Year: 2010
    ..Specific Aim 2: To dissect the mechanisms by which CTLA-4 &FOXP3 variants predispose to APS3v: (1) CTLA-4: we will test whether a 3'UTR microsatellite predisposes to APS3v by ..
  94. Role of miRNA in lung damage during TB and TB/AIDS Co-infection
    Deepak Kaushal; Fiscal Year: 2010
    ..Regulators of the granulomatous immune response include FoxP3+ regulatory T cells, IL10 and IL27...
  95. T-cell mediated immunity in chlamydia genital infection
    Kathleen Kelly; Fiscal Year: 2009
    ..We have identified CD4+FoxP3+Tregs and CD8+CXCR5+Tregs that appear in overlapping but different locations during chlamydial genital infection ..
  96. T-cell mediated immunity in chlamydia genital infection
    Kathleen A Kelly; Fiscal Year: 2010
    ..We have identified CD4+FoxP3+Tregs and CD8+CXCR5+Tregs that appear in overlapping but different locations during chlamydial genital infection ..
  97. Mechanisms of Acceptance in Mouse Renal Allografts
    Robert B Colvin; Fiscal Year: 2010
    This proposal addresses the need for definitive evidence on the role of Foxp3+/T regulatory cells in the acceptance of physiologically relevant full MHC incompatible organ grafts in various settings of operational tolerance...
  98. Immunization against Atherosclerosis
    AOSHUANG contact CHEN; Fiscal Year: 2011
    ..Importantly, CD4+CD25+Foxp3+ regulatory T cells (Treg), a subset of T cells that function to suppress the response of Teff, have been shown to ..
  99. Importance of CD5 for the function of regulatory T cells
    Subbarao Bondada; Fiscal Year: 2009
    ..They are characterized by expression of a transcription factor Foxp3 and CD25, while being quiescent. In cell transfer models T-Regs have been shown to potently suppress IBD...
  100. Regulation of Phosphoprotein Signalling in CD4+ and DN iNKT Cell Subsets
    Samuel Wilson; Fiscal Year: 2007
    ..In addition, a bias towards proinflammatory DN iNKT cells and the a failure of CD4+ iNKT cells to up regulate Foxp3 and potentially other immunoregulatory genes might contribute to the progression to type 1 diabetes...
  101. Induction and function of regulatory T cells
    Jonathan Bromberg; Fiscal Year: 2007
    ..Among the regulatory T cells that have been described are anergic CD4+CD25+ Treg. These cells express the Foxp3 transcription factor, which is to date the most specific marker for cells that possess the Treg suppressive ..