FOXP1

Summary

Gene Symbol: FOXP1
Description: forkhead box P1
Alias: 12CC4, HSPC215, MFH, QRF1, hFKH1B, forkhead box protein P1, fork head-related protein like B, glutamine-rich factor 1, mac-1-regulated forkhead
Species: human
Products:     FOXP1

Top Publications

  1. Jiang W, Li L, Tang Y, Zhang W, Liu W, Li G. Expression of FOXP1 in mucosa-associated lymphoid tissue lymphoma suggests a large tumor cell transformation and predicts a poorer prognosis in the positive thyroid patients. Med Oncol. 2012;29:3352-9 pubmed publisher
    The forkhead box protein P1 (FOXP1) expression resulted from chromosome translocation was found in MALT lymphoma, and its nuclear expression in diffuse large B cell lymphoma has been believed to be a poor prognostic factor...
  2. Li S, Weidenfeld J, Morrisey E. Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol. 2004;24:809-22 pubmed
    b>Foxp1, Foxp2, and Foxp4 are large multidomain transcriptional regulators belonging to the family of winged-helix DNA binding proteins known as the Fox family...
  3. Vernes S, Macdermot K, Monaco A, Fisher S. Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia. Eur J Hum Genet. 2009;17:1354-8 pubmed publisher
    ..b>FOXP1, the most closely related member of this subgroup, can directly interact with FOXP2 and is co-expressed in neural ..
  4. Streubel B, Vinatzer U, Lamprecht A, Raderer M, Chott A. T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma. Leukemia. 2005;19:652-8 pubmed
    ..Long-distance inverse polymerase chain reaction identified FOXP1 as the partner gene on chromosome 3. To determine the frequency of the t(3;14)(p14...
  5. Shi C, Sakuma M, Mooroka T, Liscoe A, Gao H, CROCE K, et al. Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function. Blood. 2008;112:4699-711 pubmed publisher
    Down-regulation of the forkhead transcription factor Foxp1 by integrin engagement controls monocyte differentiation in vitro...
  6. Mullighan C, Goorha S, Radtke I, Miller C, Coustan Smith E, Dalton J, et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature. 2007;446:758-64 pubmed
    ..Moreover, these data demonstrate the power of high-resolution, genome-wide approaches to identify new molecular lesions in cancer. ..
  7. Haralambieva E, Adam P, Ventura R, Katzenberger T, Kalla J, Holler S, et al. Genetic rearrangement of FOXP1 is predominantly detected in a subset of diffuse large B-cell lymphomas with extranodal presentation. Leukemia. 2006;20:1300-3 pubmed
  8. Sagaert X, De Paepe P, Libbrecht L, Vanhentenrijk V, Verhoef G, Thomas J, et al. Forkhead box protein P1 expression in mucosa-associated lymphoid tissue lymphomas predicts poor prognosis and transformation to diffuse large B-cell lymphoma. J Clin Oncol. 2006;24:2490-7 pubmed
    Gene expression profiling studies have reported upregulated mRNA expression of forkhead box protein P1 (FOXP1) in response to normal B-cell activation and high expression in a poor prognosis subtype of diffuse large B-cell lymphoma (..
  9. Green M, Gandhi M, Courtney M, Marlton P, Griffiths L. Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFkappaB activity in Follicular Lymphoma. Leuk Res. 2009;33:1699-702 pubmed publisher
    b>FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFkappaB-responsive genes...

More Information

Publications89

  1. Xue Z, Zhao C, Chua G, Tan S, Tang X, Wong S, et al. Integrin alphaMbeta2 clustering triggers phosphorylation and activation of protein kinase C delta that regulates transcription factor Foxp1 expression in monocytes. J Immunol. 2010;184:3697-709 pubmed publisher
    ..It has been shown that alpha(M)beta(2) clustering regulates the expression the transcription factor Foxp1 that has a role in monocyte differentiation...
  2. Teramitsu I, Kudo L, London S, Geschwind D, White S. Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. J Neurosci. 2004;24:3152-63 pubmed
    ..Here, in situ hybridization analyses for FoxP1 and FoxP2 in a songbird reveal a corticostriatal expression pattern congruent with the abnormalities in brain ..
  3. Gabut M, Samavarchi Tehrani P, Wang X, Slobodeniuc V, O Hanlon D, Sung H, et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147:132-46 pubmed publisher
    ..cell (ESC)-specific AS event that changes the DNA-binding preference of the forkhead family transcription factor FOXP1. We show that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required ..
  4. Craig V, Cogliatti S, Imig J, Renner C, Neuenschwander S, Rehrauer H, et al. Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1. Blood. 2011;117:6227-36 pubmed publisher
    ..We could further attribute miR-34a's tumor-suppressive effects to deregulation of its target FoxP1. FoxP1 overexpression was detected in gDLBCL but not in gastric MALT lymphoma; FoxP1 knock-down efficiently ..
  5. Brown P, Ashe S, Leich E, Burek C, Barrans S, Fenton J, et al. Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL. Blood. 2008;111:2816-24 pubmed
    The FOXP1 forkhead transcription factor is targeted by recurrent chromosome translocations in several subtypes of B-cell non-Hodgkin lymphomas, where high-level FOXP1 protein expression has been linked to a poor prognosis...
  6. Tang B, Becanovic K, Desplats P, Spencer B, Hill A, Connolly C, et al. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Hum Mol Genet. 2012;21:3097-111 pubmed publisher
    b>Forkhead box protein p1 (Foxp1), a transcription factor showing highly enriched expression in the striatum, has been implicated in central nervous system (CNS) development, but its role in the mature brain is unknown...
  7. Hoeller S, Schneider A, Haralambieva E, Dirnhofer S, Tzankov A. FOXP1 protein overexpression is associated with inferior outcome in nodal diffuse large B-cell lymphomas with non-germinal centre phenotype, independent of gains and structural aberrations at 3p14.1. Histopathology. 2010;57:73-80 pubmed publisher
    To determine the molecular epidemiology and prognostic importance of structural and numeric FOXP1 gene aberrations with respect to BCL-6 gene and to FOXP1 protein expression in 389 diffuse large B-cell lymphomas (DLBCL) from the pre-..
  8. Goatly A, Bacon C, Nakamura S, Ye H, Kim I, Brown P, et al. FOXP1 abnormalities in lymphoma: translocation breakpoint mapping reveals insights into deregulated transcriptional control. Mod Pathol. 2008;21:902-11 pubmed publisher
    Deregulation of FOXP1 expression plays an important role in lymphoma development although the underlying molecular mechanism is poorly understood...
  9. Bates G, Fox S, Han C, Launchbury R, Leek R, Harris A, et al. Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas. Breast Cancer Res Treat. 2008;111:453-9 pubmed
    ..a correlation between estrogen receptor alpha (ERalpha) and the candidate tumour suppressor gene Forkhead Box P1 (FOXP1), whose nuclear protein expression in breast tumours was associated with improved patient survival...
  10. Sagardoy A, Martínez Ferrandis J, Roa S, Bunting K, Aznar M, Elemento O, et al. Downregulation of FOXP1 is required during germinal center B-cell function. Blood. 2013;121:4311-20 pubmed publisher
    ..b>FOXP1 is a transcription factor that regulates early B-cell development, but whether it plays a role in mature B cells ..
  11. Li C, Tucker P. DNA-binding properties and secondary structural model of the hepatocyte nuclear factor 3/fork head domain. Proc Natl Acad Sci U S A. 1993;90:11583-7 pubmed
    ..An aromatic kink and a third amphipathic helix comprise the center of the domain. At the C terminus, two variable-length loops flank a putative 7-amino acid helix followed by a short basic region. ..
  12. Wang B, Lin D, Li C, Tucker P. Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J Biol Chem. 2003;278:24259-68 pubmed
    ..We report here a structure/function analysis of the Foxp1 protein...
  13. Courts C, Brunn A, Montesinos Rongen M, Siemer D, Hans V, Paulus W, et al. Preferential expression of truncated isoforms of FOXP1 in primary central nervous system lymphoma. J Neuropathol Exp Neurol. 2009;68:972-6 pubmed publisher
    Forkhead box P1 (FOXP1) protein is a transcription factor involved in cell signaling and regulation of gene expression...
  14. Shi C, Zhang X, Chen Z, Sulaiman K, Feinberg M, Ballantyne C, et al. Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1. J Clin Invest. 2004;114:408-18 pubmed
    ..forkhead transcription factor (termed Mac-1-regulated forkhead [MFH] and found subsequently to be identical to Foxp1) that is downregulated in beta(2)-integrin Mac-1-clustered compared with Mac-1-nonclustered monocytic THP-1 cells...
  15. Levine D, Ek W, Zhang R, Liu X, Onstad L, Sather C, et al. A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus. Nat Genet. 2013;45:1487-93 pubmed publisher
    ..A third is at 3p14 (rs2687201: P = 5.5 × 10(-9)) near the transcription factor FOXP1, which regulates esophageal development...
  16. Han S, Wu X, Wan L, Zeng Q, Li J, Liu Z. FOXP1 expression predicts polymorphic histology and poor prognosis in gastric mucosa-associated lymphoid tissue lymphomas. Dig Surg. 2009;26:156-62 pubmed publisher
    RATIONALE/HYPOTHESIS: Forkhead box protein P1 (FOXP1) is one member of the forkhead box protein P (FOXP) subfamily, which are transcription factors that mediate signaling and affect gene regulation, and elevated expression of FOXP1 has ..
  17. Banham A, Connors J, Brown P, Cordell J, Ott G, Sreenivasan G, et al. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res. 2005;11:1065-72 pubmed
    Gene expression profiling studies have reported up-regulated mRNA expression of the FOXP1 forkhead transcription factor in response to normal B-cell activation and high expression in a poor prognosis subtype of diffuse large B-cell ..
  18. Zhai L, Zhao Y, Ye S, Huang H, Tian Y, Wu Q, et al. Expression of PIK3CA and FOXP1 in gastric and intestinal non-Hodgkin's lymphoma of mucosa-associated lymphoid tissue type. Tumour Biol. 2011;32:913-20 pubmed publisher
    ..Recently, it has been demonstrated that karyotypic alterations involving the PIK3CA and FOXP1 genes of chromosome 3 occur in MALT lymphoma...
  19. Espinet B, Garcia Herrera A, Gallardo F, Baro C, Salgado R, Servitje O, et al. FOXP1 molecular cytogenetics and protein expression analyses in primary cutaneous large B cell lymphoma, leg-type. Histol Histopathol. 2011;26:213-21 pubmed publisher
    b>FOXP1 protein is expressed in normal activated B cells and overexpressed in a subset of diffuse large B-cell lymphomas, including primary cutaneous large B-cell lymphomas (PCLBCL), leg type...
  20. Banham A, Beasley N, Campo E, Fernandez P, Fidler C, Gatter K, et al. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res. 2001;61:8820-9 pubmed
    ..cloned cDNAs encoding its antigenic target and identified this protein as a novel putative transcription factor, FOXP1. The FOXP1 protein sequence contains predicted domains characteristic of transcription factors, including a winged ..
  21. Zhang Y, Zhang S, Wang X, Liu J, Yang L, He S, et al. Prognostic significance of FOXP1 as an oncogene in hepatocellular carcinoma. J Clin Pathol. 2012;65:528-33 pubmed publisher
    Forkhead Box P1 (FOXP1) has been described as both a tumour suppressor candidate and a potential oncogene...
  22. Schrimpf R, Gottschalk M, Metzger J, Martinsson G, Sieme H, Distl O. Screening of whole genome sequences identified high-impact variants for stallion fertility. BMC Genomics. 2016;17:288 pubmed publisher
    ..For 9 high-impact variants within the genes CFTR, OVGP1, FBXO43, TSSK6, PKD1, FOXP1, TCP11, SPATA31E1 and NOTCH1 (g...
  23. Vanacker L, Smeets D, Hoorens A, Teugels E, Algaba R, Dehou M, et al. Mixed adenoneuroendocrine carcinoma of the colon: molecular pathogenesis and treatment. Anticancer Res. 2014;34:5517-21 pubmed
    ..coli (APC), Kirsten rat sarcoma viral oncogene homolog (KRAS), B-cell CLL/lymphoma 9 (BCL9) and Forkhead Box P1 (FOXP1) genes...
  24. Sollis E, Graham S, Vino A, Froehlich H, Vreeburg M, Dimitropoulou D, et al. Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder. Hum Mol Genet. 2016;25:546-57 pubmed publisher
    De novo disruptions of the neural transcription factor FOXP1 are a recently discovered, rare cause of sporadic intellectual disability (ID)...
  25. Fox S, Brown P, Han C, Ashe S, Leek R, Harris A, et al. Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. Clin Cancer Res. 2004;10:3521-7 pubmed
    The FOXP1 protein belongs to a functionally diverse family of winged-helix or forkhead transcription factors that have diverse roles in cellular proliferation, differentiation, and neoplastic transformation...
  26. Oskay Halacli S. FOXP1 enhances tumor cell migration by repression of NFAT1 transcriptional activity in MDA-MB-231 cells. Cell Biol Int. 2017;41:102-110 pubmed publisher
    Until now, forkhead box P1 (FOXP1) has been identified as a tumor suppressor in several correlation studies in breast cancer...
  27. Li J, Hou J, Li L, Wang Y. Immunohistochemical subtypes of diffuse large B-cell lymphoma in the head and neck region. Genet Mol Res. 2015;14:3889-96 pubmed publisher
    ..mutated melanoma-associated antigen 1 (MUM1), germinal center B-cell-expressed transcript 1 (GCET1), forkhead box protein P1 (FOXP1), and LIM do-main only 2 (LMO2)...
  28. Li S, Koziol White C, Jude J, Jiang M, Zhao H, Cao G, et al. Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness. J Clin Invest. 2016;126:1978-82 pubmed publisher
    ..Here, we have shown that loss of the transcription factors forkhead box P1 (Foxp1) and Foxp4, which are critical for lung epithelial development, in the adult airway epithelium evokes a non-Th2 ..
  29. Zhao J, Li H, Zhou R, Ma G, Dekker J, Tucker H, et al. Foxp1 Regulates the Proliferation of Hair Follicle Stem Cells in Response to Oxidative Stress during Hair Cycling. PLoS ONE. 2015;10:e0131674 pubmed publisher
    ..However, the mechanisms controlling the pace of HFSC proliferation remain unclear. Here we revealed that Foxp1, a transcriptional factor, was dynamically relocated from the nucleus to the cytoplasm of HFSCs in phase ..
  30. van Keimpema M, Grüneberg L, Mokry M, van Boxtel R, van Zelm M, Coffer P, et al. The forkhead transcription factor FOXP1 represses human plasma cell differentiation. Blood. 2015;126:2098-109 pubmed publisher
    Expression of the forkhead transcription factor FOXP1 is essential for early B-cell development, whereas downregulation of FOXP1 at the germinal center (GC) stage is required for GC B-cell function...
  31. Hamdan F, Daoud H, Rochefort D, Piton A, Gauthier J, Langlois M, et al. De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment. Am J Hum Genet. 2010;87:671-8 pubmed publisher
    ..FOXP2 and its closest homolog, FOXP1, are coexpressed in brain regions that are important for language and cooperatively regulate developmental ..
  32. Middelkamp S, van Heesch S, Braat A, de Ligt J, van Iterson M, Simonis M, et al. Molecular dissection of germline chromothripsis in a developmental context using patient-derived iPS cells. Genome Med. 2017;9:9 pubmed publisher
    ..We find that three of these genes (FOXP1, DPYD, and TWIST1) are both associated with developmental disorders and differentially expressed in the patient...
  33. Chu Y, Chang C, Shiu J, Chang Y, Chen C, Chuang W. Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding. Protein Sci. 2011;20:908-24 pubmed publisher
    b>FOXP1 belongs to the P-subfamily of forkhead transcription factors and contains a conserved forkhead DNA-binding domain...
  34. Mukaigasa K, Sakuma C, Okada T, Homma S, Shimada T, Nishiyama K, et al. Motor neurons with limb-innervating character in the cervical spinal cord are sculpted by apoptosis based on the Hox code in chick embryo. Development. 2017;144:4645-4657 pubmed publisher
    ..in normal or apoptosis-inhibited chick embryos, we found that this apoptotic population is distinguishable by Foxp1 expression...
  35. Myers A, du Souich C, Yang C, Borovik L, Mwenifumbo J, Rupps R, et al. FOXP1 haploinsufficiency: Phenotypes beyond behavior and intellectual disability?. Am J Med Genet A. 2017;173:3172-3181 pubmed publisher
    ..In humans FOXP1 mutations have been associated with language and speech defects, intellectual disability, autism spectrum disorder,..
  36. Gadage V, Kembhavi S, Kumar P, Shet T. Primary cardiac diffuse large B-cell lymphoma with activated B-cell-like phenotype. Indian J Pathol Microbiol. 2011;54:591-3 pubmed publisher
    ..Histology revealed a large cell population diffusely and strongly expressing CD45, CD20, MUM1/IRF4 and FOXP1 hinting at an activated B-cell (ABC)-like phenotype...
  37. Grant A, Sabri A, Abid A, Abderrahmani Rhorfi I, Benkirane M, Souhi H, et al. A genome-wide association study of pulmonary tuberculosis in Morocco. Hum Genet. 2016;135:299-307 pubmed publisher
    ..4 × 10(-5)): rs358793 and rs17590261 were intergenic, while rs6786408 and rs916943 were located in introns of FOXP1 and AGMO, respectively...
  38. Rousso D, Qiao M, Kagan R, Yamagata M, Palmiter R, Sanes J. Two Pairs of ON and OFF Retinal Ganglion Cells Are Defined by Intersectional Patterns of Transcription Factor Expression. Cell Rep. 2016;15:1930-44 pubmed publisher
    ..Intersectional expression of Foxp1 and Brn3 transcription factors divides F-RGCs into four types, comprising two pairs, each composed of closely ..
  39. Xiao J, He B, Zou Y, Chen X, Lu X, Xie M, et al. Prognostic value of decreased FOXP1 protein expression in various tumors: a systematic review and meta-analysis. Sci Rep. 2016;6:30437 pubmed publisher
    The prognostic value of forkhead box protein P1 (FOXP1) protein expression in tumors remains controversial...
  40. Bosch M, Akhter A, Chen B, Mansoor A, LeBrun D, Good D, et al. A bioclinical prognostic model using MYC and BCL2 predicts outcome in relapsed/refractory diffuse large B-cell lymphoma. Haematologica. 2018;103:288-296 pubmed publisher
    ..was available to create tissue microarrays and perform immunohistochemistry staining for CD10, BCL6, MUM1/IRF4, FOXP1, LMO2, BCL2, MYC, P53 and phosphoSTAT3 (pySTAT3) expression...
  41. Petrakis G, Kostopoulos I, Venizelos I, Lambropoulou M, Vouras K, Vakalopoulou S, et al. Expression of the activation markers Blimp1, Foxp1 and pStat3 in extranodal diffuse large B-cell lymphomas. Histol Histopathol. 2017;32:825-834 pubmed publisher
    ..In this study, we investigated the expression of three activation markers, Blimp1, Foxp1 and pStat3, in a cohort of 35 extranodal DLBCLs homogeneously treated with R-CHOP...
  42. Bai S, Kerppola T. Opposing roles of FoxP1 and Nfat3 in transcriptional control of cardiomyocyte hypertrophy. Mol Cell Biol. 2011;31:3068-80 pubmed publisher
    ..We investigated FoxP1 interaction with Nfat3 (Nfatc4) and their effects on transcription of hypertrophy-associated genes in neonatal rat ..
  43. Cesario J, Almaidhan A, Jeong J. Expression of forkhead box transcription factor genes Foxp1 and Foxp2 during jaw development. Gene Expr Patterns. 2016;20:111-9 pubmed publisher
    ..regulators of oral development, repressed the expression of the genes encoding forkhead box transcription factors, Foxp1 and Foxp2, in the oral region...
  44. O Sullivan A, Eivers S, Mulvaney E, Kinsella B. Regulated expression of the TPβ isoform of the human T prostanoid receptor by the tumour suppressors FOXP1 and NKX3.1: Implications for the role of thromboxane in prostate cancer. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3153-3169 pubmed publisher
    ..Furthermore, the tumour suppressors FOXP1 and NKX3...
  45. Bidkhori G, Narimani Z, Hosseini Ashtiani S, Moeini A, Nowzari Dalini A, Masoudi Nejad A. Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinoma. PLoS ONE. 2013;8:e67552 pubmed publisher
    ..The genes EGFR, PIK3CA, TAF15, XIAP, VAPB, Appl1, Rab5a, ARF4, CLPTM1L, SP4, ZNF124, LPP, FOXP1, SOX18, MSX2, NFE2L2, SMARCC1, TRA2B, CBX3, PRPF6, ATP6V1C1, MYBBP1A, MACF1, GRM2, TBXA2R, PRKAR2A, PTK2, PGF and ..
  46. Bieniek Kobuszewska M, Panasiewicz G, Lipka A, Majewska M, Szafranska B. Novel SNPs and InDels discovered in two promoter regions of porcine pregnancy-associated glycoprotein 2-like subfamily (pPAG2-Ls) in crossbreed pigs. Funct Integr Genomics. 2016;16:705-715 pubmed
    ..software, revealed a total of 28 transcription factor binding sites (TFBS) and 10 TFBS (AP-1, CCAAT, CHOP:C, FOXP1, LSF, MRF-2, Myc, NF1, NF-Y, TGIF) within SNPs in the core sequences...
  47. Zou Y, Gong N, Cui Y, Wang X, Cui A, Chen Q, et al. Forkhead Box P1 (FOXP1) Transcription Factor Regulates Hepatic Glucose Homeostasis. J Biol Chem. 2015;290:30607-15 pubmed publisher
    ..Here we show that FOXP1, a transcriptional repressor, plays a key role in the regulation of systemic glucose homeostasis...
  48. Li X, Xiao J, Fröhlich H, Tu X, Li L, Xu Y, et al. Foxp1 regulates cortical radial migration and neuronal morphogenesis in developing cerebral cortex. PLoS ONE. 2015;10:e0127671 pubmed publisher
    b>FOXP1 is a member of FOXP subfamily transcription factors. Mutations in FOXP1 gene have been found in various development-related cognitive disorders...
  49. Chang S, Mislankar M, Misra C, Huang N, DaJusta D, Harrison S, et al. Genetic abnormalities in FOXP1 are associated with congenital heart defects. Hum Mutat. 2013;34:1226-30 pubmed publisher
    ..3 Mb monoallelic deletion on chromosome 3p14.1. The deletion encompassed the first four exons of FOXP1, a gene critical for normal heart development that represses cardiomyocyte proliferation and expression of Nkx2.5...
  50. Fu L, Girling J, Rogers P. Expression of Fox head protein 1 in human eutopic endometrium and endometriosis. Reprod Sci. 2008;15:243-52 pubmed publisher
    The objective of this study is to examine the localization and expression of FOXP1 in human endometrium during the menstrual cycle and in endometriotic lesions and endometrial adenocarcinoma...
  51. Baro C, Espinet B, Salido M, Colomo L, Luño E, Florensa L, et al. FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ hybridization and immunohistochemistry approach. Histol Histopathol. 2009;24:1399-404 pubmed publisher
    ..b>FOXP1 is a transcriptional regulator of B lymphopoiesis that is deregulated in some types of NHL...
  52. Gascoyne D, Lyne L, Spearman H, Buffa F, Soilleux E, Banham A. Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D. Endocrinology. 2017;158:503-515 pubmed publisher
    ..Here, immunophenotyping and FOXP1 expression profiling identified plasmablastic characteristics in DLBCL cell lines HLY-1 and SU-DHL-9, associated ..
  53. L Abbate A, Lo Cunsolo C, Macri E, Iuzzolino P, Mecucci C, Doglioni C, et al. FOXP1 and TP63 involvement in the progression of myelodysplastic syndrome with 5q- and additional cytogenetic abnormalities. BMC Cancer. 2014;14:396 pubmed publisher
    ..In particular, balanced alterations involving TP63 and FOXP1 genes were never reported in the literature...
  54. Romero M, Gapihan G, Castro Vega L, Acevedo A, Wang L, Li Z, et al. Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting. Oncotarget. 2017;8:16243-16258 pubmed publisher
    ..A combination of in silico prediction and transcriptomic analyses enabled us to identify FOXP1 as a main miR-92a target gene in PMBL, a result so far not established...
  55. Braccioli L, Vervoort S, Adolfs Y, Heijnen C, Basak O, Pasterkamp R, et al. FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression. Stem Cell Reports. 2017;9:1530-1545 pubmed publisher
    Mutations in FOXP1 have been linked to neurodevelopmental disorders including intellectual disability and autism; however, the underlying molecular mechanisms remain ill-defined...
  56. Cui R, Guan Y, Sun C, Chen L, Bao Y, Li G, et al. A tumor-suppressive microRNA, miR-504, inhibits cell proliferation and promotes apoptosis by targeting FOXP1 in human glioma. Cancer Lett. 2016;374:1-11 pubmed publisher
    ..Furthermore, we identified forkhead box protein P1 (FOXP1) as a direct target of miR-504 using microarray analysis and a luciferase assay...
  57. Asgari M, Wang W, Ioannidis N, Itnyre J, Hoffmann T, Jorgenson E, et al. Identification of Susceptibility Loci for Cutaneous Squamous Cell Carcinoma. J Invest Dermatol. 2016;136:930-937 pubmed publisher
    ..SNPs at the remaining three loci include an intronic SNP in FOXP1 at locus 3p13, an intergenic SNP at 3q28 near TP63, and an intergenic SNP at 9p22 near BNC2...
  58. Bot P, Grundmann S, Goumans M, de Kleijn D, Moll F, de Boer O, et al. Forkhead box protein P1 as a downstream target of transforming growth factor-? induces collagen synthesis and correlates with a more stable plaque phenotype. Atherosclerosis. 2011;218:33-43 pubmed publisher
    ..The forkhead box transcription factor FoxP1 modulates monocyte differentiation...
  59. Horn D, Kapeller J, Rivera Brugués N, Moog U, Lorenz Depiereux B, Eck S, et al. Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits. Hum Mutat. 2010;31:E1851-60 pubmed publisher
    ..These studies revealed three heterozygous overlapping deletions solely affecting the forkhead box P1 (FOXP1) gene. All three patients had moderate mental retardation and significant language and speech deficits...
  60. Medina E, Córdova C, Villalobos P, Reyes J, Komives E, Ramírez Sarmiento C, et al. Three-Dimensional Domain Swapping Changes the Folding Mechanism of the Forkhead Domain of FoxP1. Biophys J. 2016;110:2349-2360 pubmed publisher
    ..Here, we explore the equilibrium folding and binding mechanism of the forkhead domain of wild-type FoxP1, and of two mutants that hinder DNA-binding (R53H) and domain swapping (A39P), using size-exclusion chromatography,..
  61. Brown P, Wong K, Felce S, Lyne L, Spearman H, Soilleux E, et al. FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas. Leukemia. 2016;30:605-16 pubmed publisher
    The FOXP1 (forkhead box P1) transcription factor is a marker of poor prognosis in diffuse large B-cell lymphoma (DLBCL)...
  62. Chen R, Davis L, Guter S, Wei Q, Jacob S, Potter M, et al. Leveraging blood serotonin as an endophenotype to identify de novo and rare variants involved in autism. Mol Autism. 2017;8:14 pubmed publisher
    ..novo loss of function mutations and discovered evidence supporting two other known genes with recurrent DNVs (FOXP1 and KDM5B)...
  63. Katoh M, Katoh M. Human FOX gene family (Review). Int J Oncol. 2004;25:1495-500 pubmed
    ..FOXN3 (CHES1), FOXN4, FOXN5 (FOXR1), FOXN6 (FOXR2), FOXO1 (FOXO1A), FOXO2 (FOXO6), FOXO3 (FOXO3A), FOXO4 (MLLT7), FOXP1, FOXP2, FOXP3, FOXP4, and FOXQ1. FOXE3-FOXD2 (1p33), FOXQ1-FOXF2-FOXC1 (6p25.3), and FOXF1-FOXC2-FOXL1 (16q24...
  64. Meerschaut I, Rochefort D, Revencu N, Pètre J, Corsello C, Rouleau G, et al. FOXP1-related intellectual disability syndrome: a recognisable entity. J Med Genet. 2017;54:613-623 pubmed publisher
    Mutations in forkhead box protein P1 (FOXP1) cause intellectual disability (ID) and specific language impairment (SLI), with or without autistic features (MIM: 613670)...
  65. Mottok A, Jurinovic V, Farinha P, Rosenwald A, Leich E, Ott G, et al. FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab-containing regimens. Blood. 2017;: pubmed publisher
    ..We focused on FOXP1 and assessed its protein expression by immunohistochemistry (IHC) in a total of 763 tissue biopsies...
  66. Ijichi N, Ikeda K, Horie Inoue K, Inoue S. FOXP1 and estrogen signaling in breast cancer. Vitam Horm. 2013;93:203-12 pubmed publisher
    ..immunohistochemical analysis of breast cancer specimens has revealed that nuclear immunoreactivities of FOXP1 as well as those of FOXA1 are positively correlated with hormone receptor status, including ER? and progesterone ..
  67. Hu Z, Zhu L, Tan M, Cai M, Deng L, Yu G, et al. The expression and correlation between the transcription factor FOXP1 and estrogen receptors in epithelial ovarian cancer. Biochimie. 2015;109:42-8 pubmed publisher
    Estrogen plays an important role in the progression of ovarian cancer in humans. FOXP1 belongs to the forkhead/winged-helix transcription factor family, and previous research indicated that FOXP1 functioned as a tumor suppressor gene...
  68. Becker J, May A, Gerges C, Anders M, Veits L, Weise K, et al. Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma. Cancer Med. 2015;4:1700-4 pubmed publisher
    ..They identified genome-wide significant association for variants at three genes, namely CRTC1, FOXP1, and BARX1...
  69. Naudin C, Hattabi A, Michelet F, Miri Nezhad A, Benyoucef A, Pflumio F, et al. PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells. Blood. 2017;129:2493-2506 pubmed publisher
    ..Through a proteomic approach, we identified the FOXP1 transcription factor as a new target of PUM1/2...
  70. Luo X, Yang Z, Liu X, Liu Z, Miao X, Li D, et al. The clinicopathological significance of forkhead box P1 and forkhead box O3a in pancreatic ductal adenocarcinomas. Tumour Biol. 2017;39:1010428317699129 pubmed publisher
    ..6568-0.742). Loss of forkhead box P1 and forkhead box O3a protein expression is associated with carcinogenesis, progression, and poor prognosis in patients with pancreatic ductal adenocarcinomas. ..
  71. Hieronymus H, Iaquinta P, Wongvipat J, Gopalan A, Murali R, Mao N, et al. Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis. Nat Commun. 2017;8:1081 pubmed publisher
    A multigenic locus at 3p13-14, spanning FOXP1 to SHQ1, is commonly deleted in prostate cancer and lost broadly in a range of cancers but has unknown significance to oncogenesis or prognosis...
  72. Smith J, Avery C, Evans D, Nalls M, Meng Y, Smith E, et al. Impact of ancestry and common genetic variants on QT interval in African Americans. Circ Cardiovasc Genet. 2012;5:647-55 pubmed publisher
    ..In addition, our genome-wide association study extends the association of polymorphisms at several loci associated with repolarization in individuals of European ancestry to include individuals of African ancestry. ..
  73. Xing T, Du L, Zhuang X, Zhang L, Hao J, Wang J. Upregulation of microRNA-206 induces apoptosis of vascular smooth muscle cells and decreases risk of atherosclerosis through modulating FOXP1. Exp Ther Med. 2017;14:4097-4103 pubmed publisher
    ..function of microRNA-206 (miR-206) and the regulatory association between miR-206 and its potential target gene, FOXP1, in vascular smooth muscle cells (VSMCs)...
  74. Borovecki A, Korac P, Ventura R, Perisa M, Banham A, Dominis M. MALT1, BCL10 and FOXP1 in salivary gland mucosa-associated lymphoid tissue lymphomas. Pathol Int. 2007;57:47-51 pubmed
    ..lymphoid tissue (MALT lymphoma) pathogenesis, 17 salivary gland MALT lymphoma cases were analyzed for MALT1 and FOXP1 translocations...
  75. Shi B, Geng J, Wang Y, Wei H, Walters B, Li W, et al. Foxp1 Negatively Regulates T Follicular Helper Cell Differentiation and Germinal Center Responses by Controlling Cell Migration and CTLA-4. J Immunol. 2018;200:586-594 pubmed publisher
    ..Our previous work has shown that transcription factor Foxp1 is a critical negative regulator of Tfh cell differentiation...
  76. Yamamoto K, Ito S, Hanafusa H, Shimizu K, Ouchida M. Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression. PLoS ONE. 2015;10:e0137887 pubmed publisher
    ..Finally, FOXP1, TP53INP1, TNFAIP3, and TUSC2 were identified as miR-19a targets...
  77. Sin C, Li H, Crawford D. Transcriptional regulation by FOXP1, FOXP2, and FOXP4 dimerization. J Mol Neurosci. 2015;55:437-48 pubmed publisher
    b>FOXP1, FOXP2, and FOXP4 are three members of the FOXP gene subfamily of transcription factors involved in the development of the central nervous system...
  78. Rouhigharabaei L, Finalet Ferreiro J, Tousseyn T, van der Krogt J, Put N, Haralambieva E, et al. Non-IG aberrations of FOXP1 in B-cell malignancies lead to an aberrant expression of N-truncated isoforms of FOXP1. PLoS ONE. 2014;9:e85851 pubmed publisher
    The transcription factor FOXP1 is implicated in the pathogenesis of B-cell lymphomas through chromosomal translocations involving either immunoglobulin heavy chain (IGH) locus or non-IG sequences...
  79. Chen Z, Xiao Y, Zhang J, Li J, Liu Y, Zhao Y, et al. Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. PLoS ONE. 2011;6:e20475 pubmed publisher
    ..By RT-PCR, Western blot and immunofluorescence, we found that transcription factors E2A, FOXO1 and FOXP1 were expressed and localized to the nuclei of these cancer cells...
  80. Kim Y, Wu Q, Chen J, Xuan Z, Jung Y, Zhang M, et al. The transcriptome of human CD34+ hematopoietic stem-progenitor cells. Proc Natl Acad Sci U S A. 2009;106:8278-83 pubmed publisher
    ..The data generated from our study provide a comprehensive and uniform resource for studying hematopoiesis and stem cell biology. ..