FOXM1

Summary

Gene Symbol: FOXM1
Description: forkhead box M1
Alias: FKHL16, FOXM1A, FOXM1B, FOXM1C, HFH-11, HFH11, HNF-3, INS-1, MPHOSPH2, MPP-2, MPP2, PIG29, TRIDENT, forkhead box protein M1, Forkhead, drosophila, homolog-like 16, HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, a novel forkhead box M1 isoform FOXM1D, forkhead-related protein FKHL16, hepatocyte nuclear factor 3 forkhead homolog 11, transcription factor Trident, winged-helix factor from INS-1 cells
Species: human
Products:     FOXM1

Top Publications

  1. Wang I, Meliton L, Ren X, Zhang Y, Balli D, Snyder J, et al. Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis. PLoS ONE. 2009;4:e6609 pubmed publisher
    The Forkhead Box m1 (Foxm1) protein is induced in a majority of human non-small cell lung cancers and its expression is associated with poor prognosis...
  2. Dibb M, Han N, Choudhury J, Hayes S, Valentine H, West C, et al. The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma. Br J Cancer. 2012;107:1766-75 pubmed publisher
    The transcription factor FOXM1 is an important regulator of the cell cycle through controlling periodic gene expression during the G2 and M phases...
  3. Millour J, de Olano N, Horimoto Y, Monteiro L, Langer J, Aligue R, et al. ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. Mol Cancer Ther. 2011;10:1046-58 pubmed publisher
    In this report, we investigated the role and regulation of forkhead box M1 (FOXM1) in breast cancer and epirubicin resistance...
  4. Gialmanidis I, Bravou V, Amanetopoulou S, Varakis J, Kourea H, Papadaki H. Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas. Lung Cancer. 2009;66:64-74 pubmed publisher
    ..molecules in non-small cell lung carcinomas (NSCLC), as well as the involvement of the transcription factor FOXM1, that controls cell proliferation, in this process...
  5. Halasi M, Gartel A. Suppression of FOXM1 sensitizes human cancer cells to cell death induced by DNA-damage. PLoS ONE. 2012;7:e31761 pubmed publisher
    ..Following DNA damage FOXM1 protein levels are often elevated...
  6. Sullivan C, Liu Y, Shen J, Curtis A, Newman C, Hock J, et al. Novel interactions between FOXM1 and CDC25A regulate the cell cycle. PLoS ONE. 2012;7:e51277 pubmed publisher
    b>FOXM1 is a critical regulator of the G1/S and G2/M cell cycle transitions, as well as of the mitotic spindle assembly. Previous studies have suggested that FOXM1 regulates CDC25A gene transcription, but the mechanism remains unknown...
  7. Korver W, Roose J, Heinen K, Weghuis D, de Bruijn D, van Kessel A, et al. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. Genomics. 1997;46:435-42 pubmed
    We recently identified the winged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells...
  8. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon C, et al. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res. 2012;72:655-65 pubmed publisher
    ..We determined that levels of Cav-1 and the Forkhead transcription factor FoxM1 correlated directly in pancreatic cancer cells and tumor tissues...
  9. Christensen L, Joo J, Lee S, Wai D, Triche T, May W. FOXM1 is an oncogenic mediator in Ewing Sarcoma. PLoS ONE. 2013;8:e54556 pubmed publisher
    ..b>FOXM1 is a proliferation associated transcription factor which has increasingly been found to play a role in the ..

More Information

Publications113 found, 100 shown here

  1. Radhakrishnan S, Gartel A. FOXM1: the Achilles' heel of cancer?. Nat Rev Cancer. 2008;8:c1; author reply c2 pubmed publisher
  2. Li J, Wang Y, Luo J, Fu Z, Ying J, Yu Y, et al. miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells. FEBS Lett. 2012;586:3761-5 pubmed publisher
    ..In addition, we showed that Forkhead Box M1 (FOXM1) is a direct target of miR-134. Knockdown of FOXM1 reversed EMT resembling that of miR-134 overexpression...
  3. Monteiro L, Khongkow P, Kongsema M, Morris J, Man C, Weekes D, et al. The Forkhead Box M1 protein regulates BRIP1 expression and DNA damage repair in epirubicin treatment. Oncogene. 2013;32:4634-45 pubmed publisher
    b>FOXM1 is implicated in genotoxic drug resistance but its role and mechanism of action remain unclear...
  4. Ye H, Kelly T, Samadani U, Lim L, Rubio S, Overdier D, et al. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol Cell Biol. 1997;17:1626-41 pubmed
    ..These experiments show that the HFH-11 transcription factor is expressed in embryonic mesenchymal and epithelial cells and its expression is reactivated in these adult cell types by proliferative signals or oxidative stress. ..
  5. Myatt S, Kongsema M, Man C, Kelly D, Gomes A, Khongkow P, et al. SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene. 2014;33:4316-29 pubmed publisher
    The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis...
  6. Wang I, Chen Y, Hughes D, Ackerson T, Major M, Kalinichenko V, et al. FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem. 2008;283:20770-8 pubmed publisher
    The Forkhead box M1 (FoxM1) protein is a proliferation-specific transcription factor that plays a key role in controlling both the G(1)/S and G(2)/M transitions through the cell cycle and is essential for the development of various ..
  7. Balli D, Ustiyan V, Zhang Y, Wang I, Masino A, Ren X, et al. Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J. 2013;32:231-44 pubmed publisher
    ..Herein, we demonstrated the critical role of Forkhead Box M1 (Foxm1) transcription factor in radiation-induced pulmonary fibrosis...
  8. Zhao Y, Gao X, Zhao Y, Mirza M, Frey R, Kalinichenko V, et al. Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J Clin Invest. 2006;116:2333-43 pubmed
    ..To investigate the functional role of forkhead box M1 (FoxM1) in the mechanism of endothelial repair, we generated endothelial cell-restricted FoxM1-deficient mice (FoxM1 CKO ..
  9. Bellelli R, Castellone M, Garcia Rostan G, Ugolini C, Nucera C, Sadow P, et al. FOXM1 is a molecular determinant of the mitogenic and invasive phenotype of anaplastic thyroid carcinoma. Endocr Relat Cancer. 2012;19:695-710 pubmed publisher
    Anaplastic thyroid carcinoma (ATC) is a very aggressive thyroid cancer. forkhead box protein M1 (FOXM1) is a member of the forkhead box family of transcription factors involved in control of cell proliferation, chromosomal stability, ..
  10. Chen X, Müller G, Quaas M, Fischer M, Han N, Stutchbury B, et al. The forkhead transcription factor FOXM1 controls cell cycle-dependent gene expression through an atypical chromatin binding mechanism. Mol Cell Biol. 2013;33:227-36 pubmed publisher
    ..ChIP-seq) to investigate the genome-wide chromatin binding mechanisms used by the forkhead transcription factor FOXM1. In keeping with its previous association with cell cycle control, we demonstrate that FOXM1 binds and regulates a ..
  11. Lok G, Chan D, Liu V, Hui W, Leung T, Yao K, et al. Aberrant activation of ERK/FOXM1 signaling cascade triggers the cell migration/invasion in ovarian cancer cells. PLoS ONE. 2011;6:e23790 pubmed publisher
    ..001). Functionally, ectopic expression of FOXM1B remarkably enhanced cell migration/invasion, while FOXM1C not only increased cell proliferation but also promoted cell migration/invasion...
  12. Liu Y, Guo R, Liu L, Gao W, Zhu C, Wei J, et al. [Correlation between expression of forkhead box M1 (FOXM1) and clinicopathological features and prognosis in patients with non-small cell lung cancer (NSCLC)]. Zhonghua Zhong Liu Za Zhi. 2011;33:426-30 pubmed
    To investigate the expression of forkhead box M1 (FOXM1) and its correlation with clinicopathological features and prognosis in patients with non-small cell lung cancer (NSCLC)...
  13. Carr J, Park H, Wang Z, Kiefer M, Raychaudhuri P. FoxM1 mediates resistance to herceptin and paclitaxel. Cancer Res. 2010;70:5054-63 pubmed publisher
    ..In human breast cancer samples, overexpression of the oncogenic transcription factor FoxM1 has been suggested to be a marker of poor prognosis...
  14. Pandit B, Gartel A. FoxM1 knockdown sensitizes human cancer cells to proteasome inhibitor-induced apoptosis but not to autophagy. Cell Cycle. 2011;10:3269-73 pubmed publisher
    ..However, persistent stress can also promote extensive autophagy leading to cell death. Forkhead box M1 (FoxM1), an oncogenic transcription factor that is abundantly expressed in a wide range of human cancers...
  15. Madureira P, Varshochi R, Constantinidou D, Francis R, Coombes R, Yao K, et al. The Forkhead box M1 protein regulates the transcription of the estrogen receptor alpha in breast cancer cells. J Biol Chem. 2006;281:25167-76 pubmed
    In this study, we have identified the Forkhead transcription factor FoxM1 as a physiological regulator of estrogen receptor alpha (ERalpha) expression in breast carcinoma cells...
  16. Petrovic V, Costa R, Lau L, Raychaudhuri P, Tyner A. FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. J Biol Chem. 2008;283:453-60 pubmed
    The Forkhead box M1 (FoxM1) transcription factor is essential for cell cycle progression and mitosis...
  17. Lin M, Guo L, Liu H, Du J, Yang J, Zhang L, et al. Nuclear accumulation of glioma-associated oncogene 2 protein and enhanced expression of forkhead-box transcription factor M1 protein in human hepatocellular carcinoma. Histol Histopathol. 2010;25:1269-75 pubmed publisher
    ..in the development and progression of hepatocellular carcinoma (HCC), we investigated the expression of Gli2 and FoxM1 (forkhead-box transcription factor M1) which is one of the Gli downstream target genes modulating cell cycle ..
  18. Okada K, Fujiwara Y, Takahashi T, Nakamura Y, Takiguchi S, Nakajima K, et al. Overexpression of forkhead box M1 transcription factor (FOXM1) is a potential prognostic marker and enhances chemoresistance for docetaxel in gastric cancer. Ann Surg Oncol. 2013;20:1035-43 pubmed publisher
    Mammalian forkhead box transcription factor 1 (FoxM1) has been overexpressed and correlated with pathogenesis in a variety of human malignancies...
  19. Wang Z, Park H, Carr J, Chen Y, Zheng Y, Li J, et al. FoxM1 in tumorigenicity of the neuroblastoma cells and renewal of the neural progenitors. Cancer Res. 2011;71:4292-302 pubmed publisher
    ..These tumors also overexpress the Forkhead box transcription factor FoxM1. In this study, we investigated the roles of FoxM1 in the tumorigenicity of neuroblastoma...
  20. Halasi M, Gartel A. FOX(M1) news--it is cancer. Mol Cancer Ther. 2013;12:245-54 pubmed publisher
    b>FOXM1 is an oncogenic transcription factor of the Forkhead family and it has a well-defined role in cell proliferation and cell-cycle progression...
  21. McGovern U, Francis R, Peck B, Guest S, Wang J, Myatt S, et al. Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer. Mol Cancer Ther. 2009;8:582-91 pubmed publisher
    ..In this study, we investigated the role and regulation of FOXM1 in response to gefitinib treatment in breast cancer...
  22. Hui M, Chan K, Luk J, Lee N, Chung Y, Cheung L, et al. Cytoplasmic Forkhead box M1 (FoxM1) in esophageal squamous cell carcinoma significantly correlates with pathological disease stage. World J Surg. 2012;36:90-7 pubmed publisher
    ..This study aims to investigate the clinical correlation between Forkhead box M1 (FoxM1)and patients' parameters in ESCC...
  23. Koo C, Muir K, Lam E. FOXM1: From cancer initiation to progression and treatment. Biochim Biophys Acta. 2012;1819:28-37 pubmed publisher
    The Forkhead box protein M1 (FOXM1) transcription factor is a regulator of myriad biological processes, including cell proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue homeostasis, angiogenesis and ..
  24. Zhang N, Wei P, Gong A, Chiu W, Lee H, Colman H, et al. FoxM1 promotes ?-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesis. Cancer Cell. 2011;20:427-42 pubmed publisher
    ..Here, we report that FoxM1 is a downstream component of Wnt signaling and is critical for ?-catenin transcriptional function in tumor cells...
  25. Xu N, Zhang X, Wang X, Ge H, Wang X, Garfield D, et al. FoxM1 mediated resistance to gefitinib in non-small-cell lung cancer cells. Acta Pharmacol Sin. 2012;33:675-81 pubmed publisher
    ..b>FoxM1 is upregulated in NSCLC and associated with a poor prognosis in NSCLC patients...
  26. Sanders D, Ross Innes C, Beraldi D, Carroll J, Balasubramanian S. Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells. Genome Biol. 2013;14:R6 pubmed publisher
    The forkhead transcription factor FOXM1 is a key regulator of the cell cycle. It is frequently over-expressed in cancer and is emerging as an important therapeutic target...
  27. Cai Y, Balli D, Ustiyan V, Fulford L, Hiller A, Misetic V, et al. Foxm1 expression in prostate epithelial cells is essential for prostate carcinogenesis. J Biol Chem. 2013;288:22527-41 pubmed publisher
    ..The Foxm1 transcription factor is highly up-regulated in tumor cells, inflammatory cells, and cells of tumor ..
  28. Zhang Y, Zhang N, Dai B, Liu M, Sawaya R, Xie K, et al. FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells. Cancer Res. 2008;68:8733-42 pubmed publisher
    We previously found that FoxM1B is overexpressed in human glioblastomas and that forced FoxM1B expression in anaplastic astrocytoma cells leads to the formation of highly angiogenic glioblastoma in nude mice...
  29. Alvarez Fernandez M, Halim V, Krenning L, Aprelia M, Mohammed S, Heck A, et al. Recovery from a DNA-damage-induced G2 arrest requires Cdk-dependent activation of FoxM1. EMBO Rep. 2010;11:452-8 pubmed publisher
    ..We have shown recently that Cdk activity is required for activation of the Forkhead transcription factor FoxM1, an important regulator of gene expression in the G2 phase of the cell cycle...
  30. Mirza M, Sun Y, Zhao Y, Potula H, Frey R, Vogel S, et al. FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression. J Exp Med. 2010;207:1675-85 pubmed publisher
    ..The forkhead transcription factor FoxM1 is essential for endothelial proliferation after vascular injury...
  31. Xia L, Mo P, Huang W, Zhang L, Wang Y, Zhu H, et al. The TNF-?/ROS/HIF-1-induced upregulation of FoxMI expression promotes HCC proliferation and resistance to apoptosis. Carcinogenesis. 2012;33:2250-9 pubmed publisher
    The proliferation-specific transcription factor Forkhead box M1 (FoxM1) acts as a master regulator of cancer cell growth and survival and plays an important role in the development of hepatocellular carcinoma...
  32. Kong X, Li L, Li Z, Le X, Huang C, Jia Z, et al. Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res. 2013;73:3987-96 pubmed publisher
    ..We identified five FOXM1 isoforms present in pancreatic cancer: FOXM1a, FOXM1b, and FOXM1c along with two isoforms tentatively designated as FOXM1b1 and FOXM1b2 because they were ..
  33. Laoukili J, Alvarez M, Meijer L, Stahl M, Mohammed S, Kleij L, et al. Activation of FoxM1 during G2 requires cyclin A/Cdk-dependent relief of autorepression by the FoxM1 N-terminal domain. Mol Cell Biol. 2008;28:3076-87 pubmed publisher
    The Forkhead transcription factor FoxM1 is an important regulator of gene expression during the G(2) phase...
  34. Bhat U, Halasi M, Gartel A. Thiazole antibiotics target FoxM1 and induce apoptosis in human cancer cells. PLoS ONE. 2009;4:e5592 pubmed publisher
    Forkhead box M1 (FoxM1) oncogenic transcription factor represents an attractive therapeutic target in the fight against cancer, because it is overexpressed in a majority of human tumors...
  35. Uddin S, Hussain A, Ahmed M, Siddiqui K, Al Dayel F, Bavi P, et al. Overexpression of FoxM1 offers a promising therapeutic target in diffuse large B-cell lymphoma. Haematologica. 2012;97:1092-100 pubmed publisher
    b>FoxM1 has been shown to play a critical role in the pathogenesis of various epithelial malignancies. However, its role in lymphoid malignancies has not been fully clarified...
  36. Qian J, Luo Y, Gu X, Zhan W, Wang X. Twist1 promotes gastric cancer cell proliferation through up-regulation of FoxM1. PLoS ONE. 2013;8:e77625 pubmed publisher
    ..In the present study, we show that Twist 1 overexpression leads to a significant up-regulation of FoxM1, which plays a key role in cell cycle progression in gastric cancer cells...
  37. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen J, et al. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008;10:1076-82 pubmed publisher
    ..Here we report that Forkhead Box M1 (FoxM1), a substrate of Plk1, controls a transcriptional programme that mediates Plk1-dependent regulation of cell-cycle ..
  38. Chen W, Yuan K, Tao Z, Xiao B. Deletion of Forkhead Box M1 transcription factor reduces malignancy in laryngeal squamous carcinoma cells. Asian Pac J Cancer Prev. 2011;12:1785-8 pubmed
    The transcription factor, Forkhead Box M1 (FoxM1), has a specific expression pattern during the cell cycle...
  39. Wu X, Chen Y, Liu D, Sha J, Xuan H, Bo J, et al. Increased expression of forkhead box M1 protein is associated with poor prognosis in clear cell renal cell carcinoma. Med Oncol. 2013;30:346 pubmed publisher
    b>Forkhead box protein M1 (FoxM1) is crucial in the regulation of various biological processes, including cell proliferation, organogenesis, and angiogenesis. Overexpression of FoxM1 is associated with carcinogenesis...
  40. Khongkow P, Karunarathna U, Khongkow M, Gong C, Gomes A, Yague E, et al. FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance. Oncogene. 2014;33:4144-55 pubmed publisher
    b>FOXM1 is implicated in genotoxic drug resistance but its mechanism of action remains elusive...
  41. Teh M, Wong S, Neill G, Ghali L, Philpott M, Quinn A. FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res. 2002;62:4773-80 pubmed
    ..isoforms (a, b, and c) were detected in human skin and cultured keratinocytes, and the transcriptionally active FOXM1b isoform was found to be up-regulated in BCCs...
  42. Kwok J, Peck B, Monteiro L, Schwenen H, Millour J, Coombes R, et al. FOXM1 confers acquired cisplatin resistance in breast cancer cells. Mol Cancer Res. 2010;8:24-34 pubmed publisher
    The transcription factor Forkhead box M1 (FOXM1) is a key regulator of cell proliferation and is overexpressed in many forms of primary cancers, leading to uncontrolled cell division and genomic instability...
  43. Gemenetzidis E, Elena Costea D, Parkinson E, Waseem A, Wan H, Teh M. Induction of human epithelial stem/progenitor expansion by FOXM1. Cancer Res. 2010;70:9515-26 pubmed publisher
    ..The frequent, and often early, upregulation of the FOXM1 transcription factor in the majority of human cancers suggests that it may participate in the initiation of human ..
  44. Wang I, Chen Y, Hughes D, Petrovic V, Major M, Park H, et al. Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase. Mol Cell Biol. 2005;25:10875-94 pubmed
    The Forkhead box m1 (Foxm1) gene is critical for G(1)/S transition and essential for mitotic progression. However, the transcriptional mechanisms downstream of FoxM1 that control these cell cycle events remain to be determined...
  45. Park H, Costa R, Lau L, Tyner A, Raychaudhuri P. Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Mol Cell Biol. 2008;28:5162-71 pubmed publisher
    The forkhead box M1 (FoxM1) transcription factor is overexpressed in many cancers, and in mouse models it is required for tumor progression. FoxM1 activates expression of the cell cycle genes required for both S and M phase progression...
  46. Nakamura S, Hirano I, Okinaka K, Takemura T, Yokota D, Ono T, et al. The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia. Carcinogenesis. 2010;31:2012-21 pubmed publisher
    ..The FOXM1 messenger RNA (mRNA) expressed in AML cell lines was predominantly the FOXM1B isoform, and its levels were significantly higher than in normal high aldehyde dehydrogenase activity (ALDH(hi)) ..
  47. Sun H, Teng M, Liu J, Jin D, Wu J, Yan D, et al. FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria. Cancer Lett. 2011;306:214-22 pubmed publisher
    ..In the present study, Forkhead box M1 (FOXM1) expression and its prognostic role have been investigated in hepatocellular carcinoma (HCC) treated by orthotopic ..
  48. Raychaudhuri P, Park H. FoxM1: a master regulator of tumor metastasis. Cancer Res. 2011;71:4329-33 pubmed publisher
    The FoxM1 transcription factor gene is overexpressed in cancer. Its expression is stimulated by oncogenic signaling pathways and reactive oxygen species. It is also a target of regulation by the tumor suppressor genes...
  49. Priller M, Pöschl J, Abrão L, Von Bueren A, Cho Y, Rutkowski S, et al. Expression of FoxM1 is required for the proliferation of medulloblastoma cells and indicates worse survival of patients. Clin Cancer Res. 2011;17:6791-801 pubmed publisher
    The transcription factor Forkhead box M1 (FoxM1) is a key regulator of cell-cycle progression...
  50. Bhat U, Jagadeeswaran R, Halasi M, Gartel A. Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells. J Biol Chem. 2011;286:41425-33 pubmed publisher
    Using mass spectrometric analysis we found that oncogenic transcription factor FOXM1 that is overexpressed in a majority of human cancers interacts with multifunctional protein NPM, which is also overexpressed in a variety of human ..
  51. Bektas N, Haaf A, Veeck J, Wild P, Lüscher Firzlaff J, Hartmann A, et al. Tight correlation between expression of the Forkhead transcription factor FOXM1 and HER2 in human breast cancer. BMC Cancer. 2008;8:42 pubmed publisher
    b>FOXM1 regulates expression of cell cycle related genes that are essential for progression into DNA replication and mitosis...
  52. Xia L, Huang W, Wang B, Liu M, Zhang Q, Yan W, et al. Transcriptional up-regulation of FoxM1 in response to hypoxia is mediated by HIF-1. J Cell Biochem. 2009;106:247-56 pubmed publisher
    The proliferation-specific Forkhead box M1 (FoxM1) transcription factor is overexpressed in cancer cells and acts as an important regulator of cancer cell growth and survival...
  53. Yu J, Deshmukh H, Payton J, Dunham C, Scheithauer B, Tihan T, et al. Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor. Clin Cancer Res. 2011;17:1924-34 pubmed publisher
    ..To identify survival-associated genomic biomarkers, we performed high-resolution array-based comparative genomic hybridization (aCGH) on a large set of MPNSTs...
  54. Karadedou C, Gomes A, Chen J, Petkovic M, Ho K, Zwolinska A, et al. FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene. 2012;31:1845-58 pubmed publisher
    ..expression experiments showed that FOXO3a represses the proximal VEGF promoter, whereas another Forkhead member, FOXM1, induces VEGF expression...
  55. Liu M, Dai B, Kang S, Ban K, Huang F, Lang F, et al. FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells. Cancer Res. 2006;66:3593-602 pubmed
    ..In the present study, we found that FoxM1B was the predominant FoxM1 isoform expressed in human glioma but not in normal brain tissue...
  56. Yang D, Son C, Lee S, Choi P, Lee K, Roh M. Forkhead box M1 expression in pulmonary squamous cell carcinoma: correlation with clinicopathologic features and its prognostic significance. Hum Pathol. 2009;40:464-70 pubmed publisher
    Forkhead box M1 (FoxM1) transcription factor has been shown to play important roles in regulating the expression of genes that are involved in cell proliferation, differentiation, and transformation by promoting both G(1)/S and G(2)/M ..
  57. Wu Q, Liu C, Tai M, Liu D, Lei L, Wang R, et al. Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro. Acta Pharmacol Sin. 2010;31:361-6 pubmed publisher
    To investigate the effects of small interfering RNA (siRNA) knockdown of forkhead box M1 (FoxM1) on the proliferation and invasion capacities of human hepatocellular carcinoma MHCC-97H cells in vitro...
  58. Uddin S, Ahmed M, Hussain A, Abubaker J, Al Sanea N, AbdulJabbar A, et al. Genome-wide expression analysis of Middle Eastern colorectal cancer reveals FOXM1 as a novel target for cancer therapy. Am J Pathol. 2011;178:537-47 pubmed publisher
    ..Among the up-regulated genes, forkhead box M1 (FOXM1) has been shown to play a critical role in pathogenesis of various malignancies...
  59. Ahmed M, Uddin S, Hussain A, Alyan A, Jehan Z, Al Dayel F, et al. FoxM1 and its association with matrix metalloproteinases (MMP) signaling pathway in papillary thyroid carcinoma. J Clin Endocrinol Metab. 2012;97:E1-E13 pubmed publisher
    Forkhead boxM1 (FoxM1) transcription factor has been shown to promote pathogenesis of several malignancies. FoxM1 has also been shown to be associated with matrix metalloproteinases (MMP) in various cancers...
  60. Xia J, Wang H, Liang L, Peng B, Wu Z, Chen L, et al. Overexpression of FOXM1 is associated with poor prognosis and clinicopathologic stage of pancreatic ductal adenocarcinoma. Pancreas. 2012;41:629-35 pubmed publisher
    Oncogenic transcription factor forkhead box M1 (FoxM1)-related clinicopathologic characteristics and prognosis of patients with pancreatic ductal adenocarcinoma (PDA) have not been identified...
  61. Carr J, Kiefer M, Park H, Li J, Wang Z, Fontanarosa J, et al. FoxM1 regulates mammary luminal cell fate. Cell Rep. 2012;1:715-29 pubmed publisher
    Elevated expression of FoxM1 in breast cancer correlates with an undifferentiated tumor phenotype and a negative clinical outcome. However, a role for FoxM1 in regulating mammary differentiation was not known...
  62. Yao K, Sha M, Lu Z, Wong G. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. J Biol Chem. 1997;272:19827-36 pubmed
    ..of human WIN has been previously isolated as a putative phosphorylation substrate, MPM2-reactive phosphoprotein 2 (MPP2); WIN may be regulated by phosphorylation...
  63. Wonsey D, Follettie M. Loss of the forkhead transcription factor FoxM1 causes centrosome amplification and mitotic catastrophe. Cancer Res. 2005;65:5181-9 pubmed
    Expression of the forkhead transcription factor FoxM1 correlates with proliferative status in a variety of normal and transformed cell types...
  64. Kim I, Ackerson T, Ramakrishna S, Tretiakova M, Wang I, Kalin T, et al. The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res. 2006;66:2153-61 pubmed
    The proliferation-specific Forkhead Box m1 (Foxm1 or Foxm1b) transcription factor (previously called HFH-11B, Trident, Win, or MPP2) regulates expression of cell cycle genes essential for progression into DNA replication and mitosis...
  65. Wierstra I, Alves J. Transcription factor FOXM1c is repressed by RB and activated by cyclin D1/Cdk4. Biol Chem. 2006;387:949-62 pubmed
    The proliferation-stimulating transactivator FOXM1c (MPP2) is repressed by RB and activated by cyclin D1/Cdk4 and therefore behaves like E2F...
  66. Chen Y, Dominguez Brauer C, Wang Z, Asara J, Costa R, Tyner A, et al. A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. J Biol Chem. 2009;284:30695-707 pubmed publisher
    The Forkhead box M1 (FoxM1) transcription factor is critical for expression of the genes essential for G(1)/S transition and mitotic progression...
  67. Wang I, Zhang Y, Snyder J, Sutherland M, Burhans M, Shannon J, et al. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol. 2010;347:301-14 pubmed publisher
    ..Foxm1 (previously called Foxm1b, HFH-11B, Trident, Win, or MPP2) is expressed in multiple cell types and plays important roles in cellular proliferation, ..
  68. Jiang L, Wang P, Deng B, Huang C, Tang W, Lu H, et al. Overexpression of Forkhead Box M1 transcription factor and nuclear factor-?B in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. Hum Pathol. 2011;42:1185-93 pubmed publisher
  69. Alvarez Fernandez M, Halim V, Aprelia M, Laoukili J, Mohammed S, Medema R. Protein phosphatase 2A (B55?) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation. J Biol Chem. 2011;286:33029-36 pubmed publisher
    The forkhead transcription factor FoxM1 controls expression of a large number of genes that are specifically expressed during the G(2) phase of the cell cycle...
  70. Teh M, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta A, et al. FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. PLoS ONE. 2012;7:e34329 pubmed publisher
    The oncogene FOXM1 has been implicated in all major types of human cancer. We recently showed that aberrant FOXM1 expression causes stem cell compartment expansion resulting in the initiation of hyperplasia...
  71. Park Y, Jung S, Jennings N, Rodriguez Aguayo C, Peng G, Lee S, et al. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis. 2012;33:1843-53 pubmed publisher
    ..Our results revealed that Forkhead box protein M1 (FOXM1) is the top-ranked survival-associated transcription factor in patients with triple-negative ..
  72. Xia L, Huang W, Tian D, Zhu H, Zhang Y, Hu H, et al. Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma. J Hepatol. 2012;57:600-12 pubmed publisher
    Forkhead box M1 (FoxM1) is a master regulator of tumor metastasis that plays an important role in the development of hepatocellular carcinoma (HCC)...
  73. Mencalha A, Binato R, Ferreira G, Du Rocher B, Abdelhay E. Forkhead box M1 (FoxM1) gene is a new STAT3 transcriptional factor target and is essential for proliferation, survival and DNA repair of K562 cell line. PLoS ONE. 2012;7:e48160 pubmed publisher
    ..However, the role of FoxM1, the signaling involved in its activation and its role in leukemia are poorly known...
  74. Yang C, Chen H, Yu L, Shan L, Xie L, Hu J, et al. Inhibition of FOXM1 transcription factor suppresses cell proliferation and tumor growth of breast cancer. Cancer Gene Ther. 2013;20:117-24 pubmed publisher
    The forkhead box M1 (FOXM1) transcription factor regulates the expression of genes essential for cell proliferation and transformation and is implicated in tumorigenesis and tumor progression...
  75. Kambach D, Sodi V, Lelkes P, Azizkhan Clifford J, Reginato M. ErbB2, FoxM1 and 14-3-3? prime breast cancer cells for invasion in response to ionizing radiation. Oncogene. 2014;33:589-98 pubmed publisher
    ..Activation of ErbB2-dependent signaling results in upregulation of the forkhead family transcription factor, FoxM1, and its transcriptional targets, including matrix metalloproteinase 2 (MMP2)...
  76. Xu N, Jia D, Chen W, Wang H, Liu F, Ge H, et al. FoxM1 is associated with poor prognosis of non-small cell lung cancer patients through promoting tumor metastasis. PLoS ONE. 2013;8:e59412 pubmed publisher
    b>FoxM1 has been reported to be important in initiation and progression of various tumors. However, whether FoxM1 has any indication for prognosis in non-small cell lung cancer patients remains unclear...
  77. Grant G, Brooks L, Zhang X, Mahoney J, Martyanov V, Wood T, et al. Identification of cell cycle-regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors. Mol Biol Cell. 2013;24:3634-50 pubmed publisher
    ..We identify genomic loci bound by the G2/M transcription factor FOXM1 by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) and associate these with cell ..
  78. Laoukili J, Kooistra M, Bras A, Kauw J, Kerkhoven R, Morrison A, et al. FoxM1 is required for execution of the mitotic programme and chromosome stability. Nat Cell Biol. 2005;7:126-36 pubmed
    ..Here we show that the Forkhead transcription factor FoxM1 regulates expression of many G2-specific genes and is essential for chromosome stability...
  79. Laoukili J, Stahl M, Medema R. FoxM1: at the crossroads of ageing and cancer. Biochim Biophys Acta. 2007;1775:92-102 pubmed
    ..Here we review the current knowledge of the role played by FoxM1 in these various processes...
  80. Wierstra I, Alves J. FOXM1, a typical proliferation-associated transcription factor. Biol Chem. 2007;388:1257-74 pubmed
    b>FOXM1 is a typical proliferation-associated transcription factor: it stimulates proliferation by promoting S-phase entry as well as M-phase entry and is involved in proper execution of mitosis...
  81. Laoukili J, Alvarez Fernandez M, Stahl M, Medema R. FoxM1 is degraded at mitotic exit in a Cdh1-dependent manner. Cell Cycle. 2008;7:2720-6 pubmed
    The Forkhead transcription factor FoxM1 is required for the timely expression of many mitotic regulators, such as Cyclin B, Plk1, Aurora B and Cdc25B...
  82. Francis R, Myatt S, Krol J, Hartman J, Peck B, McGovern U, et al. FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer. Int J Oncol. 2009;35:57-68 pubmed
    ..We investigated the relationship between HER2 and the transcription factor FoxM1 in breast cancer...
  83. Chen C, Chien C, Huang C, Hwang C, Chuang H, Fang F, et al. Expression of FLJ10540 is correlated with aggressiveness of oral cavity squamous cell carcinoma by stimulating cell migration and invasion through increased FOXM1 and MMP-2 activity. Oncogene. 2009;28:2723-37 pubmed publisher
    ..One of the upstream regulators of MMP-2 is FOXM1, which is overexpressed in a microarray dataset of OCSCC...
  84. Waseem A, Ali M, Odell E, Fortune F, Teh M. Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol. 2010;46:536-42 pubmed publisher
    We recently showed that upregulation of a key oncogene FOXM1 precedes head and neck squamous cell carcinoma (HNSCC) malignancy...
  85. Huynh K, Soh J, Dash R, Sarkar D, Fisher P, Kang D. FOXM1 expression mediates growth suppression during terminal differentiation of HO-1 human metastatic melanoma cells. J Cell Physiol. 2011;226:194-204 pubmed publisher
    ..During this process, the transcription factor FOXM1 is down-regulated potentially inhibiting transactivation of target genes including those involved in G(2)/M ..
  86. Sun H, Li M, Lu J, Yan D, Zhou C, Fan J, et al. Overexpression of Forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma. Oncol Rep. 2011;25:1533-9 pubmed publisher
    The aim of this study was to detect the expression of the Forkhead box M1 (FOXM1) protein in human hepatocellular carcinoma (HCC) and to associate FOXM1 expression with clinicopathological features of the patients, and predict the ..
  87. Chu X, Zhu Z, Chen L, Wang J, Su Q, Yang J, et al. FOXM1 expression correlates with tumor invasion and a poor prognosis of colorectal cancer. Acta Histochem. 2012;114:755-62 pubmed publisher
    b>FOXM1, a member of the Forkhead Box (Fox) family of transcription factors, plays a critical role in tumor development and metastasis...
  88. de Olano N, Koo C, Monteiro L, Pinto P, Gomes A, Aligue R, et al. The p38 MAPK-MK2 axis regulates E2F1 and FOXM1 expression after epirubicin treatment. Mol Cancer Res. 2012;10:1189-202 pubmed
    E2F1 is responsible for the regulation of FOXM1 expression, which plays a key role in epirubicin resistance. Here, we examined the role and regulation of E2F1 in response to epirubicin in cancer cells...
  89. Xue Y, Xiao R, Long D, Zou X, Wang X, Zhang G, et al. Overexpression of FoxM1 is associated with tumor progression in patients with clear cell renal cell carcinoma. J Transl Med. 2012;10:200 pubmed publisher
    Fork head box M1 (FoxM1) is a proliferation-associated transcription factor essential for cell cycle progression...
  90. Xu N, Wu S, Wang H, Wang Q, Bai C. Involvement of FoxM1 in non-small cell lung cancer recurrence. Asian Pac J Cancer Prev. 2012;13:4739-43 pubmed
    ..This study set out to assess the role of FoxM1 in the recurrence of non-small cell lung cancer...
  91. Qu K, Xu X, Liu C, Wu Q, Wei J, Meng F, et al. Negative regulation of transcription factor FoxM1 by p53 enhances oxaliplatin-induced senescence in hepatocellular carcinoma. Cancer Lett. 2013;331:105-14 pubmed publisher
    Previous studies have demonstrated the involvement of transcriptional factor forkhead box M1 (FoxM1) in cellular senescence of hepatocellular carcinoma (HCC)...
  92. Schimmel J, Eifler K, Sigurðsson J, Cuijpers S, Hendriks I, Verlaan de Vries M, et al. Uncovering SUMOylation dynamics during cell-cycle progression reveals FoxM1 as a key mitotic SUMO target protein. Mol Cell. 2014;53:1053-66 pubmed publisher
    ..this and identified 593 proteins to be SUMO-2 modified, including the Forkhead box transcription factor M1 (FoxM1), a key regulator of cell-cycle progression and chromosome segregation...