FOXI1

Summary

Gene Symbol: FOXI1
Description: forkhead box I1
Alias: FKH10, FKHL10, FREAC-6, FREAC6, HFH-3, HFH3, HNF-3/fork-head homolog 3, HNF-3/fork-head homolog-3, forkhead box protein I1, forkhead-like 10, forkhead-related activator 6, forkhead-related protein FKHL10, forkhead-related transcription factor 6, hepatocyte nuclear factor 3 forkhead homolog 3
Species: human

Top Publications

  1. ncbi The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney
    D G Overdier
    Department of Biochemistry, University of Illinois, Chicago, Illinois 60612 7334, USA
    J Biol Chem 272:13725-30. 1997
  2. doi Molecular and functional studies of 4 candidate loci in Pendred syndrome and nonsyndromic hearing loss
    Valentina Cirello
    Dept of Medical Sciences, Universita degli Studi, Milan, Italy
    Mol Cell Endocrinol 351:342-50. 2012
  3. pmc Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear
    Beatriz Lorente-Cánovas
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Dis Model Mech 6:434-42. 2013
  4. ncbi Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays
    Oliver Wessely
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Dev Biol 269:552-66. 2004
  5. doi Screening of SLC26A4, FOXI1, KCNJ10, and GJB2 in bilateral deafness patients with inner ear malformation
    Kaitian Chen
    Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat Sen University and Institute of Otorhinolaryngology, Sun Yat Sen University, Guangzhou, PR China
    Otolaryngol Head Neck Surg 146:972-8. 2012
  6. doi Conditions that influence the response to Fgf during otic placode induction
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 364:1-10. 2012
  7. doi Genetic diagnosis and cochlear implantation for patients with nonsyndromic hearing loss and enlarged vestibular aqueduct
    R Lai
    Institute of Otology, Department of Otolaryngology and Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, China
    J Laryngol Otol 126:349-55. 2012
  8. doi Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish
    Z Y Hu
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cell Death Dis 4:e900. 2013
  9. ncbi The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons
    Susie A Lee
    Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143 0446, USA
    Development 130:2669-79. 2003
  10. pmc A gene network that coordinates preplacodal competence and neural crest specification in zebrafish
    Neha Bhat
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 373:107-17. 2013

Research Grants

  1. GENETIC REGULATION OF INNER EAR FORMATION
    Monte Westerfield; Fiscal Year: 2010
  2. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2007
  3. Non-Syndromic Hearing Loss -- A Collaborative Study
    Richard Smith; Fiscal Year: 2007
  4. ACTIVE H+ TRANSPORT IN URINARY ACIDIFICATION
    Qais Al Awqati; Fiscal Year: 2006
  5. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir El Dahr; Fiscal Year: 2006
  6. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir El Dahr; Fiscal Year: 2007
  7. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El Dahr; Fiscal Year: 2010
  8. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
  9. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El Dahr; Fiscal Year: 2010
  10. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El Dahr; Fiscal Year: 2010

Scientific Experts

  • Birgitte Mønster Christensen
  • Silvia Dossena
  • Stefan Hans
  • Samir S El-Dahr
  • M Katoh
  • Qais Al-Awqati
  • Olivier Bricaud
  • Samir El Dahr
  • Qais Al Awqati
  • Samir S El Dahr
  • Richard Smith
  • Takahiro Ohyama
  • Monte Westerfield
  • Jizhou Yan
  • Bruce B Riley
  • Sandra Rodrigo Blomqvist
  • Neha Bhat
  • Mahesh S Padanad
  • Hilmar Vidarsson
  • Keely S Solomon
  • Sven Enerback
  • Shawn M Burgess
  • Alexei Nechiporuk
  • Hye Joo Kwon
  • Tao Yang
  • Andreas Fritz
  • Narges Aghaallaei
  • Priya Landa
  • Renfang Song
  • Yongchuan Chai
  • Beatriz Lorente-Cánovas
  • Z Y Hu
  • Atsushi Fujita
  • R Lai
  • Xuelong Wang
  • Valentina Cirello
  • Kaitian Chen
  • Ian K Quigley
  • Estelle Lopez
  • Stephen Mercer
  • Andres Moreno-Estrada
  • Chen Chi Wu
  • Laurence Jonard
  • Masahiro Esaki
  • Makoto Kunisada
  • Elly M Sweet
  • Karen P Steel
  • Jue Zeng
  • Shun Kuo Sun
  • Thomas Czerny
  • Sarah Hochmann
  • Bonny B Millimaki
  • Baubak Bajoghli
  • Tor Linbo
  • David W Raible
  • Sarah Pauley
  • Ingo Kurth
  • Melinda D Mackereth
  • Francois Jouret
  • Su Jin Kwak
  • Oliver Wessely
  • Bengt R Johansson
  • Malin Hulander
  • C Rodriguez-Antona
  • Susie A Lee
  • Robert M Nissen
  • Hongtae Kim
  • Zhiwu Huang
  • Lucy Jenkins
  • Zoe J Golder
  • Zheng Tao
  • J W Tong
  • Maria Bitner-Glindzicz
  • Fiona E Karet Frankl
  • Noriko Miyake
  • Y Han
  • Elizabeth E Norgett
  • Yun Li
  • Ihor V Yosypiv
  • Graeme Preston
  • J P Zhang
  • Hao Wu
  • W Qin
  • Ann Marie Differ
  • Neil Ingham
  • J Meng
  • Yoshinori Tsurusaki
  • Mitsuko Nakashima
  • Xiaohua Li
  • Lei Li

Detail Information

Publications64

  1. ncbi The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney
    D G Overdier
    Department of Biochemistry, University of Illinois, Chicago, Illinois 60612 7334, USA
    J Biol Chem 272:13725-30. 1997
    ..These putative HFH-3 target genes include the Na/K-ATPase, Na/H and anion exchangers, E-cadherin, and mineralocorticoid receptor genes as well as genes for the transcription factors HNF-1, vHNF-1, and HNF-4...
  2. doi Molecular and functional studies of 4 candidate loci in Pendred syndrome and nonsyndromic hearing loss
    Valentina Cirello
    Dept of Medical Sciences, Universita degli Studi, Milan, Italy
    Mol Cell Endocrinol 351:342-50. 2012
    ..PS or non-syndromic deafness were submitted to genetic/functional analyzes of SLC26A4, of its binding domain for FOXI1 (FOXI1-DBD), of the transcription activator FOXI1, and of the potassium channel KCNJ10...
  3. pmc Mice deficient in H+-ATPase a4 subunit have severe hearing impairment associated with enlarged endolymphatic compartments within the inner ear
    Beatriz Lorente-Cánovas
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Dis Model Mech 6:434-42. 2013
    ..A regulatory link between Atp6v0a4, Foxi1 and Pds has been reported and we found that the endolymphatic sac of Atp6v0a4(-/-) mice expresses both Foxi1 and ..
  4. ncbi Analysis of Spemann organizer formation in Xenopus embryos by cDNA macroarrays
    Oliver Wessely
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, CA 90095 1662, USA
    Dev Biol 269:552-66. 2004
    ..Ventral-specific abundant cDNAs included S10-40-H5, members of the Hyaluronan synthase family, Xvent-2 and XFD2/FoxI1. A differential probe of dorsal and ventral lips identified many more organizer-specific cDNAs than the screens ..
  5. doi Screening of SLC26A4, FOXI1, KCNJ10, and GJB2 in bilateral deafness patients with inner ear malformation
    Kaitian Chen
    Department of Otorhinolaryngology, The First Affiliated Hospital, Sun Yat Sen University and Institute of Otorhinolaryngology, Sun Yat Sen University, Guangzhou, PR China
    Otolaryngol Head Neck Surg 146:972-8. 2012
    ..SLC26A4 is considered to be the major involved gene. Recently, FOXI1 and KCNJ10 mutations have been linked to enlarged vestibular aqueducts and GJB2 mutations linked to temporal bone ..
  6. doi Conditions that influence the response to Fgf during otic placode induction
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 364:1-10. 2012
    ..Elevated Fgf also expands expression of the putative competence factor Foxi1, which is required for Fgf to expand other otic markers...
  7. doi Genetic diagnosis and cochlear implantation for patients with nonsyndromic hearing loss and enlarged vestibular aqueduct
    R Lai
    Institute of Otology, Department of Otolaryngology and Head and Neck Surgery, Second Xiangya Hospital, Central South University, Changsha, China
    J Laryngol Otol 126:349-55. 2012
    ..To review the genotype and cochlear implantation outcome of patients with nonsyndromic hearing loss and enlarged vestibular aqueduct...
  8. doi Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish
    Z Y Hu
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Cell Death Dis 4:e900. 2013
    ..Mil) dysregulation also caused abnormal expression of hearing-associated genes, including hmx2, fgf3, fgf8a, foxi1, otop1, pax2.1 and tmieb during zebrafish organogenesis...
  9. ncbi The zebrafish forkhead transcription factor Foxi1 specifies epibranchial placode-derived sensory neurons
    Susie A Lee
    Department of Biopharmaceutical Sciences, University of California, San Francisco, CA 94143 0446, USA
    Development 130:2669-79. 2003
    ..which epibranchial placodes are defective, disrupts the fork headrelated, winged helix domain-containing protein Foxi1. Foxi1 is expressed in lateral placodal progenitor cells...
  10. pmc A gene network that coordinates preplacodal competence and neural crest specification in zebrafish
    Neha Bhat
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 373:107-17. 2013
    ..Elevated Bmp establishes preplacodal competence throughout the ventral ectoderm by coinducing Tfap2a, Tfap2c, Foxi1 and Gata3...
  11. pmc Lack of significant association between mutations of KCNJ10 or FOXI1 and SLC26A4 mutations in Pendred syndrome/enlarged vestibular aqueducts
    Priya Landa
    North East Thames Regional Genetics Service Laboratory, Great Ormond Street Hospital for Children NHS Foundation Trust, 37 Queen Square, York House, London WC1N 3BH, UK
    BMC Med Genet 14:85. 2013
    ..Two genes, KCNJ10, encoding an inwardly rectifying potassium channel and FOXI1, a transcriptional factor gene, are thought to play a role in the disease phenotypes.
  12. doi Molecular etiology of hearing impairment associated with nonsyndromic enlarged vestibular aqueduct in East China
    Yongchuan Chai
    Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Am J Med Genet A 161:2226-33. 2013
    Recessive mutations in SLC26A4 and in rarer cases double heterozygous mutations of FOXI1/SLC26A4 and KCNJ10/SLC26A4 lead to hearing impairment associated with enlarged vestibular aqueduct (EVA), the most common inner ear malformation...
  13. pmc Identification of early requirements for preplacodal ectoderm and sensory organ development
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, United States of America
    PLoS Genet 6:e1001133. 2010
    ..Initially, Bmp is required before gastrulation to co-induce four transcription factors, Tfap2a, Tfap2c, Foxi1, and Gata3, which establish preplacodal competence throughout the nonneural ectoderm...
  14. doi A unique case of de novo 5q33.3-q34 triplication with uniparental isodisomy of 5q34-qter
    Atsushi Fujita
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Am J Med Genet A 161:1904-9. 2013
    ..3-q34, with the exception of hearing loss. The FOXI1 gene, which causes autosomal recessive deafness (OMIM 600791, DFNB4) when mutated, was contained within the ..
  15. ncbi Identification of the elements regulating the expression of the phospholipase C delta1
    Hongtae Kim
    Neuroscience Genome Research Center, The Catholic University of Korea, Seoul
    Mol Cells 14:29-34. 2002
    ..3' deletion constructs of the PLC-delta1 promoter and electronic mobility shift assays suggested that the E-box and HFH3 binding sites are cell-type specific elements, and that Sp-1 is a major transcriptional activator of a majority of ..
  16. pmc Deletion of the prorenin receptor from the ureteric bud causes renal hypodysplasia
    Renfang Song
    Department of Pediatrics, Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana, United States of America
    PLoS ONE 8:e63835. 2013
    ..had marked kidney hypoplasia, widespread apoptosis of medullary collecting duct cells and decreased expression of Foxi1, AE1 and H(+)-ATPase α4 mRNA...
  17. doi Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage
    Stefan Hans
    Technische Universitat Dresden, Biotechnology Center and DFG Center for Regenerative Therapies Dresden Cluster of Excellence, Tatzberg 47 49, Dresden, Germany
    Development 140:1936-45. 2013
    ..In zebrafish, the otic-epibranchial progenitor domain (OEPD) is induced by Fgf signaling in a Foxi1- and Dlx3b/4b-dependent manner, but the functional differences of Foxi1 and Dlx3b/4b in subsequent cell fate ..
  18. pmc Two origins of blastemal progenitors define blastemal regeneration of zebrafish lower jaw
    Xuelong Wang
    Institute for Marine Biosystems and Neurosciences, Institutes of Marine Sciences, Shanghai Ocean University, Shanghai, China
    PLoS ONE 7:e45380. 2012
    ..These cells are transformed into two populations of blastemal progenitors: foxi1-expression and isl1-expression, before giving rise to cartilage, bone, and muscle...
  19. pmc Transcriptional control of terminal nephron differentiation
    Samir S El-Dahr
    Section of Pediatric Nephrology, Department of Pediatrics, SL 37, Tulane Univ Health Sciences Center, 1430 Tulane Ave, New Orleans, LA 70112, USA
    Am J Physiol Renal Physiol 294:F1273-8. 2008
    ..nuclear factor-1beta) promote the terminal epithelial differentiation fate, others (Notch, Brn-1, IRX, KLF4, and Foxi1) tend to regulate differentiation of specific nephron segments and individual cell types...
  20. pmc Mechanism of development of ionocytes rich in vacuolar-type H(+)-ATPase in the skin of zebrafish larvae
    Masahiro Esaki
    Department of Biological Sciences, Tokyo Institute of Technology, Midori ku, Yokohama, Japan
    Dev Biol 329:116-29. 2009
    ..In the present study, we analyzed a zebrafish mutant, quadro (quo), deficient in foxi1 gene expression and found that foxi1 is essential for development of an MRC subpopulation rich in vacuolar-type H(+..
  21. pmc Requirement for Shh and Fox family genes at different stages in sweat gland development
    Makoto Kunisada
    Laboratory of Genetics, National Institute on Aging, National Institutes of Health, NIH Biomedical Research Center, Baltimore, MD 21224, USA
    Hum Mol Genet 18:1769-78. 2009
    ..During the further development of sweat gland secretory portions, Foxa1 and Foxi1, not at all expressed in hair follicles, were progressively up-regulated in WT but not in Tabby footpads...
  22. doi Phenotypic analyses and mutation screening of the SLC26A4 and FOXI1 genes in 101 Taiwanese families with bilateral nonsyndromic enlarged vestibular aqueduct (DFNB4) or Pendred syndrome
    Chen Chi Wu
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan
    Audiol Neurootol 15:57-66. 2010
    ..we screened related genomic fragments, including the SLC26A4 coding regions, the SLC26A4 promoter and the FOXI1 transcription factor gene, in 101 Taiwanese families, and analyzed their phenotypic and genotypic results...
  23. doi Screening of SLC26A4, FOXI1 and KCNJ10 genes in unilateral hearing impairment with ipsilateral enlarged vestibular aqueduct
    Laurence Jonard
    AP HP, Centre de Référence des Surdités Généttiques, Hopital Armand Trousseau, Paris, France
    Int J Pediatr Otorhinolaryngol 74:1049-53. 2010
    ..To investigate the implication of SLC26A4, FOXI and KCNJ10 genes in unilateral hearing impairment associated with ipsilateral inner ear malformation (Enlargement of the vestibular aqueduct and/or Mondini dysplasia)...
  24. pmc The forkhead transcription factor Foxi1 is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney and epididymis
    Hilmar Vidarsson
    Center of Medical Genetics, Institute of Biomedicine, The Sahlgrenska Academy, Goteborg University, Goteborg, Sweden
    PLoS ONE 4:e4471. 2009
    ..that expression of four such subunits A1, B1, E2 and a4 all co-localize with the forkhead transcription factor Foxi1 in a subset of epithelial cells at these three locations...
  25. pmc African signatures of recent positive selection in human FOXI1
    Andres Moreno-Estrada
    Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Institut de Biologia Evolutiva UPF CSIC, Parc de Recerca Biomedica de Barcelona, 08003 Barcelona, Spain
    BMC Evol Biol 10:267. 2010
    The human FOXI1 gene codes for a transcription factor involved in the physiology of the inner ear, testis, and kidney. Using three interspecies comparisons, it has been suggested that this may be a gene under human-specific selection...
  26. doi Variants in CFTR untranslated regions are associated with congenital bilateral absence of the vas deferens
    Estelle Lopez
    Université Montpellier1, UFR de Medecine, Montpellier, France
    J Med Genet 48:152-9. 2011
    ..Despite extensive testing for point mutations and large rearrangements, a small proportion of alleles still remains unidentified in CBAVD patients...
  27. pmc Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24
    Mahesh S Padanad
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 351:90-8. 2011
    ..In zebrafish, both are initiated by localized Fgf signaling plus the ubiquitous competence factor Foxi1, and both express pax8 and sox3 in response...
  28. doi Identification of SLC26A4 mutations in patients with hearing loss and enlarged vestibular aqueduct using high-resolution melting curve analysis
    Stephen Mercer
    Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville, Melbourne, Australia
    Genet Test Mol Biomarkers 15:365-8. 2011
    ..We also used this approach to scan for mutations in KCNJ10 and FOXI1, two genes reported to play a role in the pathogenesis of Pendred syndrome and enlarged vestibular aqueduct...
  29. doi Using a yeast inverse one-hybrid system to identify functional binding sites of transcription factors
    Jizhou Yan
    Institute for Marine Biosystem and Neurosciences, Department of Hydrobiology, Shanghai Ocean University, College of Fisheries and Life Sciences, Lingang New City, Shanghai, China
    Methods Mol Biol 786:275-90. 2012
    ..g., zebrafish FoxI1. The bound fragments in hundreds of positive clones are sequenced and retested for their binding activities using ..
  30. doi Molecular and functional characterization of human pendrin and its allelic variants
    Silvia Dossena
    Institute of Pharmacology and Toxicology, Paracelsus Medical University, Salzburg, Austria
    Cell Physiol Biochem 28:451-66. 2011
    ..the pendrin coding region, such as its promoter region and/or the coding regions of functionally related genes (FOXI1, KCNJ10), should be taken into account...
  31. pmc Specification of ion transport cells in the Xenopus larval skin
    Ian K Quigley
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Development 138:705-14. 2011
    ..Like PSCs in other species, we show that the expression of these genes is likely to be driven by an ortholog of foxi1, which is also sufficient to promote the formation of PSC precursors...
  32. ncbi Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma
    C Rodriguez-Antona
    Departamento de Bioquimica, Facultad de Medicina, Universidad de Valencia, Valencia, Spain
    Mol Pharmacol 63:1180-9. 2003
    ..These findings revealed that C/EBP alpha and HNF-3 gamma cooperatively regulate CYP3A4 expression in hepatic cells by a mechanism that probably involves chromatin remodeling...
  33. pmc Genome wide screens in yeast to identify potential binding sites and target genes of DNA-binding proteins
    Jue Zeng
    Division of Hematology Oncology, Department of Medicine, University of California, Irvine, CA, USA
    Nucleic Acids Res 36:e8. 2008
    ..The experimental approach was validated with the tumor suppressor protein p53 and the forkhead protein FoxI1 using genomic libraries for zebrafish and mouse generated by shotgun cloning of short genomic fragments...
  34. ncbi Distinct roles of Fgf8, Foxi1, Dlx3b and Pax8/2 during otic vesicle induction and maintenance in medaka
    Narges Aghaallaei
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinarplatz 1, A 1210 Vienna, Austria
    Dev Biol 307:408-20. 2007
    ..We demonstrate that misexpression of Fgf8, Dlx3b and Foxi1 during early gastrulation is sufficient to produce ectopic otic vesicles...
  35. ncbi Changes in retinoic acid signaling alter otic patterning
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 134:2449-58. 2007
    ..Excess RA leads to ectopic foxi1 expression throughout the entire preplacodal domain. Foxi1 provides competence to adopt an otic fate...
  36. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004
    ..further provide evidence that pax8 expression and pax2a expression are regulated by two independent factors, Foxi1 and Dlx3b, respectively. Combined loss of both factors eliminates all indications of otic specification...
  37. ncbi Expression of mouse Foxi class genes in early craniofacial development
    Takahiro Ohyama
    Gonda Department of Cell and Molecular Biology, House Ear Institute, 2100 West 3rd Street, Los Angeles, CA 90057, USA
    Dev Dyn 231:640-6. 2004
    ..Its expression becomes restricted to the ectoderm and the endoderm of the branchial pouches at E10.5. Foxi1 expression is first detected in the endolymphatic duct in the otic vesicle at E10.5...
  38. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
    ..In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest-acting genes in this process...
  39. pmc Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1
    Sandra Rodrigo Blomqvist
    Medical Genetics, Department of Medical Biochemistry, Institute of Anatomy and Cell Biology, Goteborg University, Sweden
    J Clin Invest 113:1560-70. 2004
    While macro- and microscopic kidney development appear to proceed normally in mice that lack Foxi1, electron microscopy reveals an altered ultrastructure of cells lining the distal nephron...
  40. pmc A fork in the road of cell differentiation in the kidney tubule
    Qais Al-Awqati
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:1528-30. 2004
    ..In this issue, Blomqvist et al. find that mice lacking Foxi1 have no intercalated cells in the kidney...
  41. ncbi Expression and phylogenetic analyses of three zebrafish FoxI class genes
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 228:301-7. 2003
    ..We have reported previously the identification of zebrafish foxi1, which is required for otic placode and jaw development...
  42. ncbi Zebrafish foxi one modulates cellular responses to Fgf signaling required for the integrity of ear and jaw patterning
    Robert M Nissen
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Development 130:2543-54. 2003
    ..We identified foxi one (foo), the zebrafish ortholog of Foxi1 (FREAC6, FKHL10, HFH-3, Fkh10) and a member of the forkhead domain transcriptional regulator family, as the gene mutated ..
  43. ncbi Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice
    Malin Hulander
    Medical Genetics, Department of Medical Biochemistry, Institute of Anatomy and Cell Biology, Goteborg University, Box 440, SE 405 30 Goteborg, Sweden
    Development 130:2013-25. 2003
    Mice that lack the winged helix/forkhead gene Foxi1 (also known as Fkh10) are deaf and display shaker/waltzer behavior, an indication of disturbed balance. While Foxi1 is expressed in the entire otic vesicle at E9...
  44. ncbi Zebrafish foxi1 mediates otic placode formation and jaw development
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 130:929-40. 2003
    ..We show that hearsay disrupts foxi1, a forkhead domain-containing gene, which is expressed in otic precursor cells before placodes become visible; ..
  45. ncbi The winged helix transcription factor Fkh10 is required for normal development of the inner ear
    M Hulander
    Department of Molecular Biology, The Lundberg Laboratory, Goteborg University, Sweden
    Nat Genet 20:374-6. 1998
    ..These findings implicate Fkh10 as an early regulator necessary for development of both cochlea and vestibulum and identify its human homologue FKHL10 as a previously unknown candidate deafness gene at 5q34.
  46. ncbi Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)
    C Larsson
    Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden
    Genomics 30:464-9. 1995
    ..HGMW-approved symbols FKHL5, FKHL7, FKHL8, FKHL9 and FKHL10). We also report the sequence and the chromosomal position of a novel human forkhead gene, freac-8 (FKHL12)...
  47. pmc Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
    S Pierrou
    Department of Molecular Biology, Goteborg University, Sweden
    EMBO J 13:5002-12. 1994
    ..Applying a circular permutation assay, we show that binding of FREAC proteins to their cognate sites results in bending of the DNA at an angle of 80-90 degrees...
  48. ncbi Human FOX gene family (Review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 25:1495-500. 2004
    ..foxd2, foxd3, foxd4, foxd5 (foxd4l1), foxd6 (foxd4l3), foxe1, foxe2, foxe3, foxf1, foxf2, foxg1 (foxg1b), foxh1, foxi1, foxj1, foxj2, foxj3, foxk1, foxk2, foxl1, foxl2, foxm1, foxn1, foxn2 (htlf), foxn3 (ches1), foxn4, foxn5 (foxr1), ..
  49. ncbi Zebrafish pax8 is required for otic placode induction and plays a redundant role with Pax2 genes in the maintenance of the otic placode
    Melinda D Mackereth
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 132:371-82. 2005
    ..In contrast, the phenotype caused by disrupting foxi1, which is required for pax8 expression, was not enhanced by simultaneously disrupting pax8...
  50. ncbi Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 132:3717-30. 2005
    ..Surprisingly, ectodermal foxi1 expression, a marker for the epibranchial placode precursors, is present in both endoderm-deficient embryos and ..
  51. pmc Transcriptional control of SLC26A4 is involved in Pendred syndrome and nonsyndromic enlargement of vestibular aqueduct (DFNB4)
    Tao Yang
    Department of Otolaryngology Head and Neck, University of Iowa, Iowa City, IA 52242, USA
    Am J Hum Genet 80:1055-63. 2007
    ..We have identified and characterized a key transcriptional regulatory element in the SLC26A4 promoter that binds FOXI1, a transcriptional activator of SLC26A4. In nine patients with PS or nonsyndromic EVA, a novel c...
  52. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all ..
  53. ncbi Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent
    Shun Kuo Sun
    Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 303:675-86. 2007
    ..However, the forkhead factor, Foxi1, is required for both otic and epibranchial placode development...
  54. ncbi Specification of epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 134:611-23. 2007
    ..Here, we show that zebrafish embryos mutant for fgf3 and fgf8 do not express early EB placode markers, including foxi1 and pax2a...
  55. ncbi Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch
    Bonny B Millimaki
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Development 134:295-305. 2007
    ..Fgf3 and Fgf8 are upstream activators of atoh1 genes during both phases, and foxi1, pax8 and dlx genes regulate atoh1b in the preplacode...
  56. ncbi The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear
    Olivier Bricaud
    Leslie and Susan Gonda Goldschmied Cell and Molecular Biology Department, House Ear Institute, Los Angeles, California 90057, USA
    J Neurosci 26:10438-51. 2006
    ..Furthermore, six1 expression appears to be regulated by pax2b and also by foxi1 (forkhead box I1) as expected for an early inducer of the otic placode...
  57. ncbi Expression of marker genes during early ear development in medaka
    Sarah Hochmann
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinarplatz 1, A 1210 Vienna, Austria
    Gene Expr Patterns 7:355-62. 2007
    ..Further investigations on the molecular level identified in zebrafish Fgf3, Fgf8, Foxi1, Pax8, Dlx3b and Dlx4b genes as key players during the induction phase...
  58. pmc Epididymal expression of the forkhead transcription factor Foxi1 is required for male fertility
    Sandra Rodrigo Blomqvist
    Center of Medical Genetics, Institute of Biomedicine, Goteborg University, Goteborg, Sweden
    EMBO J 25:4131-41. 2006
    ..This depends on active proton secretion into the epididymal lumen. We have identified Foxi1 as an important regulator of gene expression in narrow and clear cells-the major proton secretory cells of ..
  59. ncbi Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear
    Sarah Pauley
    Creighton University, Department of Biomedical Sciences, Omaha, Nebraska 68178, USA
    Dev Dyn 235:2470-82. 2006
    ..Several Fox genes (Foxi1, Foxg1) are expressed in the developing otocyst of both zebrafish and mammals...
  60. pmc The forkhead transcription factor FoxI1 remains bound to condensed mitotic chromosomes and stably remodels chromatin structure
    Jizhou Yan
    National Human Genome Research Institute, Genome Technology Branch, NIH, Bldg 50, Rm 5537, 50 South Dr, Bethesda, MD 20892, USA
    Mol Cell Biol 26:155-68. 2006
    ..We created a stable cell line expressing FoxI1-green fluorescent protein (GFP) or FoxI1-V5 fusion proteins under control of the reverse tetracycline-controlled ..
  61. ncbi Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis
    Francois Jouret
    Division of Nephrology, Universite Catholique de Louvain, 10 Avenue Hippocrate, Brussels, Belgium B 1200
    J Am Soc Nephrol 16:3235-46. 2005
    ..expression of IC-specific a4, B1, G3, and C2 subunits, after the induction of the forkhead transcription factor Foxi1. From E15.5, Foxi1 mRNA was detected in IC, where it co-distributed with B1 in late nephrogenesis...
  62. pmc The forkhead transcription factor Foxi1 directly activates the AE4 promoter
    Ingo Kurth
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Butenfeld 42, 22529 Hamburg, Germany
    Biochem J 393:277-83. 2006
    ..Mice with a targeted disruption of the gene for the forkhead transcription factor Foxi1 display renal tubular acidosis due to an intercalated cell-differentiation defect...
  63. pmc Identification of nine tissue-specific transcription factors of the hepatocyte nuclear factor 3/forkhead DNA-binding-domain family
    D E Clevidence
    Department of Biochemistry M C 536, University of Illinois College of Medicine, Chicago 60612
    Proc Natl Acad Sci U S A 90:3948-52. 1993
    ..The HNF-3/fkh motif therefore comprises a large gene family of transcription factors that play a role in tissue-specific gene regulation and development...

Research Grants42

  1. GENETIC REGULATION OF INNER EAR FORMATION
    Monte Westerfield; Fiscal Year: 2010
    ..and that the Fgf and Bmp signaling pathways converge on a set of transcription factors, notably Dlx3b, Sox9a, and Foxi1, that mediate induction and differentiation of the otic primordium...
  2. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2007
    ..In addition, recent studies have shown that zebrafish foxi1 is required for otic and jaw development...
  3. Non-Syndromic Hearing Loss -- A Collaborative Study
    Richard Smith; Fiscal Year: 2007
    ..ARNSD genes; (2) To define genotype-phenotype associations in persons with DFNB1 deafness; (3) To study Pendred syndrome as a complex disease, focusing on the role of FOXI1 and its interacting partners in the Pendred syndrome phenotype.
  4. ACTIVE H+ TRANSPORT IN URINARY ACIDIFICATION
    Qais Al Awqati; Fiscal Year: 2006
    ..These studies should define the function of this critical new protein in differentiation of the kidney tubule, in acid base balance and in early embryonic development. ..
  5. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir El Dahr; Fiscal Year: 2006
    ..The results should advance our understanding of the transcriptional program of epithelial cell differentiation and elucidate a novel function for p53 in regulating epithelial cell differentiation in the kidney. ..
  6. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir El Dahr; Fiscal Year: 2007
    ..We anticipate that new pathogenetic paradigms and therapeutic strategies will emerge from our studies that can hopefully be applied for the treatment of renal dysgenesis. ..
  7. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El Dahr; Fiscal Year: 2010
    ....
  8. Histone Deacetylases and Kidney Development
    Samir S El Dahr; Fiscal Year: 2010
    ..Thus, understanding the epigenetic regulation of kidney development may open new avenues to the treatment or prevention of kidney and urinary tract malformations and kidney failure. ..
  9. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El Dahr; Fiscal Year: 2010
    ..g., BdkrB2-/-) interacts with a defined embryonic stressor (gestational salt) to alter the regulation of kidney development may open new avenues to the treatment or prevention of kidney and urinary tract malformations. ..
  10. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El Dahr; Fiscal Year: 2010
    ....
  11. Histone Deacetylases and Kidney Development
    Samir El Dahr; Fiscal Year: 2009
    ..Thus, understanding the epigenetic regulation of kidney development may open new avenues to the treatment or prevention of kidney and urinary tract malformations and kidney failure. ..
  12. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir El Dahr; Fiscal Year: 2009
    ....
  13. ACTIVE H+ TRANSPORT IN URINARY ACIDIFICATION
    Qais Al Awqati; Fiscal Year: 2002
    ....
  14. INDUCIBLE DYSPLASTIC NEPHROPATHY IN B2-DEFICENT MICE
    Samir El Dahr; Fiscal Year: 2003
    ....