FOXC1

Summary

Gene Symbol: FOXC1
Description: forkhead box C1
Alias: ARA, ASGD3, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3, forkhead box protein C1, forkhead box C1 protein, forkhead, drosophila, homolog-like 7, forkhead-related activator 3, forkhead-related protein FKHL7, forkhead-related transcription factor 3, forkhead/winged helix-like transcription factor 7, myeloid factor-delta
Species: human
Products:     FOXC1

Top Publications

  1. Pierrou S, Hellqvist M, Samuelsson L, Enerback S, Carlsson P. Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending. EMBO J. 1994;13:5002-12 pubmed
    ..Applying a circular permutation assay, we show that binding of FREAC proteins to their cognate sites results in bending of the DNA at an angle of 80-90 degrees. ..
  2. Xu Z, Ding S, Zhou L, Xie H, Chen K, Zhang W, et al. FOXC1 contributes to microvascular invasion in primary hepatocellular carcinoma via regulating epithelial-mesenchymal transition. Int J Biol Sci. 2012;8:1130-41 pubmed
    ..the expression of 8 EMT-related transcription factors (TFs) in HCC patients with or without MVI and found that FOXC1 expression was significantly higher in patients with MVI than those without MVI (P < 0.05)...
  3. Honkanen R, Nishimura D, Swiderski R, Bennett S, Hong S, Kwon Y, et al. A family with Axenfeld-Rieger syndrome and Peters Anomaly caused by a point mutation (Phe112Ser) in the FOXC1 gene. Am J Ophthalmol. 2003;135:368-75 pubmed
    Mutations of the forkhead transcription factor gene FOXC1 result in anterior segment anomalies. No description of the spectrum of defects resulting from a single point mutation of this gene exists in the ophthalmology literature...
  4. Dejeux E, Rønneberg J, Solvang H, Bukholm I, Geisler S, Aas T, et al. DNA methylation profiling in doxorubicin treated primary locally advanced breast tumours identifies novel genes associated with survival and treatment response. Mol Cancer. 2010;9:68 pubmed publisher
    ..the methylation patterns in the promoter regions of 14 genes (ABCB1, ATM, BRCA1, CDH3, CDKN2A, CXCR4, ESR1, FBXW7, FOXC1, GSTP1, IGF2, HMLH1, PPP2R2B, and PTEN) in 75 well-described pre-treatment samples from locally advanced breast ..
  5. Panicker S, Sampath S, Mandal A, Reddy A, Ahmed N, Hasnain S. Novel mutation in FOXC1 wing region causing Axenfeld-Rieger anomaly. Invest Ophthalmol Vis Sci. 2002;43:3613-6 pubmed
    ..The FOXC1 gene was amplified from genomic DNA of members of an ARA-affected family and control subjects using four novel ..
  6. Wang W, McNatt L, Shepard A, Jacobson N, Nishimura D, Stone E, et al. Optimal procedure for extracting RNA from human ocular tissues and expression profiling of the congenital glaucoma gene FOXC1 using quantitative RT-PCR. Mol Vis. 2001;7:89-94 pubmed
    ..high quality RNA from human donor eyes and to determine the expression profile of the congenital glaucoma gene FOXC1 in human ocular tissues...
  7. Ito Y, Footz T, Murphy T, Courtens W, Walter M. Analyses of a novel L130F missense mutation in FOXC1. Arch Ophthalmol. 2007;125:128-35 pubmed
    To understand how the novel L130F mutation, found in 2 patients with Axenfeld-Rieger syndrome, disrupts function of the forkhead box C1 protein (FOXC1).
  8. Fuse N, Takahashi K, Yokokura S, Nishida K. Novel mutations in the FOXC1 gene in Japanese patients with Axenfeld-Rieger syndrome. Mol Vis. 2007;13:1005-9 pubmed
    Mutations in the forkhead transcription factor (FOXC1) gene have been shown to cause juvenile glaucoma associated with a variety of anterior-segment anomalies...
  9. Khan A, Aldahmesh M, Al Amri A. Heterozygous FOXC1 mutation (M161K) associated with congenital glaucoma and aniridia in an infant and a milder phenotype in her mother. Ophthalmic Genet. 2008;29:67-71 pubmed publisher
    ..Both parents and the infant underwent diagnostic FOXC1 DNA sequencing...

More Information

Publications79

  1. Weisschuh N, Wolf C, Wissinger B, Gramer E. A novel mutation in the FOXC1 gene in a family with Axenfeld-Rieger syndrome and Peters' anomaly. Clin Genet. 2008;74:476-80 pubmed publisher
    ..Five patients from a family with Peters' anomaly and ARS were screened for mutations in the PITX2, CYP1B1 and FOXC1 genes by direct sequencing...
  2. Nishimura D, Searby C, Alward W, Walton D, Craig J, Mackey D, et al. A spectrum of FOXC1 mutations suggests gene dosage as a mechanism for developmental defects of the anterior chamber of the eye. Am J Hum Genet. 2001;68:364-72 pubmed
    Mutations in the forkhead transcription-factor gene (FOXC1), have been shown to cause defects of the anterior chamber of the eye that are associated with developmental forms of glaucoma...
  3. Huang L, Chi J, Berry F, Footz T, Sharp M, Walter M. Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells. Invest Ophthalmol Vis Sci. 2008;49:5243-9 pubmed publisher
    Mutations in the human forkhead box C1 gene (FOXC1) cause Axenfeld-Rieger (AR) malformations, often leading to glaucoma. Understanding the function of FOXC1 necessitates characterizing the proteins that interact with FOXC1...
  4. Xia L, Huang W, Tian D, Zhu H, Qi X, Chen Z, et al. Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma. Hepatology. 2013;57:610-24 pubmed publisher
    ..Thus, it is critical to discover the mechanisms underlying HCC metastasis. Forkhead box C1 (FoxC1), a member of the Fox family of transcription factors, induces epithelial-mesenchymal transition (EMT) and ..
  5. Mears A, Mirzayans F, Gould D, Pearce W, Walter M. Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25. Am J Hum Genet. 1996;59:1321-7 pubmed
    Autosomal dominant iridogoniodysgenesis anomaly (IGDA) is characterized by iris hypoplasia and goniodysgenesis with frequent juvenile glaucoma...
  6. Ito Y, Footz T, Berry F, Mirzayans F, Yu M, Khan A, et al. Severe molecular defects of a novel FOXC1 W152G mutation result in aniridia. Invest Ophthalmol Vis Sci. 2009;50:3573-9 pubmed publisher
    b>FOXC1 mutations result in Axenfeld-Rieger syndrome, a disorder characterized by a broad spectrum of malformations of the anterior segment of the eye and an elevated risk for glaucoma...
  7. Strungaru M, Dinu I, Walter M. Genotype-phenotype correlations in Axenfeld-Rieger malformation and glaucoma patients with FOXC1 and PITX2 mutations. Invest Ophthalmol Vis Sci. 2007;48:228-37 pubmed
    To improve the understanding of Axenfeld-Rieger Malformation (ARM)-associated glaucoma and to determine the best glaucoma treatment for patients with ARM who have known genetic defects in FOXC1 or PITX2.
  8. Weisschuh N, Dressler P, Schuettauf F, Wolf C, Wissinger B, Gramer E. Novel mutations of FOXC1 and PITX2 in patients with Axenfeld-Rieger malformations. Invest Ophthalmol Vis Sci. 2006;47:3846-52 pubmed
    To determine the prevalence of FOXC1 and PITX2 mutations and to assess clinical phenotypes in a cohort of German patients with Axenfeld-Rieger malformations.
  9. Berry F, Lines M, Oas J, Footz T, Underhill D, Gage P, et al. Functional interactions between FOXC1 and PITX2 underlie the sensitivity to FOXC1 gene dose in Axenfeld-Rieger syndrome and anterior segment dysgenesis. Hum Mol Genet. 2006;15:905-19 pubmed
    Axenfeld-Rieger ocular dysgenesis is associated with mutations of the human PITX2 and FOXC1 genes, which encode transcription factors of the homeodomain and forkhead types, respectively...
  10. Nishimura D, Swiderski R, Alward W, Searby C, Patil S, Bennet S, et al. The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25. Nat Genet. 1998;19:140-7 pubmed
    ..One of these, FKHL7, encoding a forkhead transcription factor, is in close proximity to the breakpoint in the balanced translocation ..
  11. Saleem R, Banerjee Basu S, Berry F, Baxevanis A, Walter M. Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1. Hum Mol Genet. 2003;12:2993-3005 pubmed
    Five missense mutations (P79L, P79T, I91S, I91T and R127H) within the forkhead DNA-binding domain of the FOXC1 transcription factor, identified in patients with Axenfeld-Rieger (AR) malformations, were studied to identify the effects of ..
  12. Mirzayans F, Gould D, Heon E, Billingsley G, Cheung J, Mears A, et al. Axenfeld-Rieger syndrome resulting from mutation of the FKHL7 gene on chromosome 6p25. Eur J Hum Genet. 2000;8:71-4 pubmed
    Mutations in the forkhead-like 7 (FKHL7) gene have been recently shown to cause juvenile glaucoma and anterior segment anomalies...
  13. Saleem R, Banerjee Basu S, Berry F, Baxevanis A, Walter M. Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1. Am J Hum Genet. 2001;68:627-41 pubmed
    Five missense mutations of the winged-helix FOXC1 transcription factor, found in patients with Axenfeld-Rieger (AR) malformations, were investigated for their effects on FOXC1 structure and function...
  14. Wang L, Gu F, Liu C, Wang R, Li J, Xu J. High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma. Tumour Biol. 2013;34:853-8 pubmed publisher
    Accumulating evidence for overexpression of FOXC1 in various types of human cancer suggests that it plays a key role in tumor biology. However, little is known about the function of FOXC1 in pancreatic ductal adenocarcinoma (PDA)...
  15. Tumer Z, Bach Holm D. Axenfeld-Rieger syndrome and spectrum of PITX2 and FOXC1 mutations. Eur J Hum Genet. 2009;17:1527-39 pubmed publisher
    ..ARS shows genetic heterogeneity and mutations of the two genes, PITX2 and FOXC1, are known to be associated with the pathogenesis...
  16. Tamimi Y, Skarie J, Footz T, Berry F, Link B, Walter M. FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. Hum Mol Genet. 2006;15:3229-40 pubmed
    The forkhead C1 (FOXC1) transcription factor is involved in the development and regulation of several organs, including the eye, where FOXC1 alterations cause iris, trabecular meshwork and corneal anomalies...
  17. RAY P, Wang J, Qu Y, Sim M, Shamonki J, Bagaria S, et al. FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer. Cancer Res. 2010;70:3870-6 pubmed publisher
    ..Here, we report overexpression of the transcription factor FOXC1 as a consistent feature of BLBC compared with other molecular subtypes of breast cancer...
  18. Wang J, Ray P, Sim M, Zhou X, Lu K, Lee A, et al. FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-?B signaling. Oncogene. 2012;31:4798-802 pubmed publisher
    ..The forkhead box transcription factor FOXC1 has recently been identified as a critical functional biomarker for BLBC...
  19. Berry F, Skarie J, Mirzayans F, Fortin Y, Hudson T, Raymond V, et al. FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the transcriptional regulation of FOXO1A. Hum Mol Genet. 2008;17:490-505 pubmed
    Mutations in the human FOXC1 transcription factor gene underlie Axenfeld-Rieger (AR) syndrome, a disorder characterized by anterior segment malformations in the eye and glaucoma...
  20. Kawase C, Kawase K, Taniguchi T, Sugiyama K, Yamamoto T, Kitazawa Y, et al. Screening for mutations of Axenfeld-Rieger syndrome caused by FOXC1 gene in Japanese patients. J Glaucoma. 2001;10:477-82 pubmed
    Mutations in the forkhead transcription factor gene (FOXC1) have been recently shown to cause some cases of juvenile glaucoma associated with a variety of anterior-segment anomalies...
  21. Aldinger K, Lehmann O, Hudgins L, Chizhikov V, Bassuk A, Ades L, et al. FOXC1 is required for normal cerebellar development and is a major contributor to chromosome 6p25.3 Dandy-Walker malformation. Nat Genet. 2009;41:1037-42 pubmed publisher
    ..Here we characterize a second DWM-linked locus on 6p25.3, showing that deletions or duplications encompassing FOXC1 are associated with cerebellar and posterior fossa malformations including cerebellar vermis hypoplasia (CVH), ..
  22. Berry F, Mirzayans F, Walter M. Regulation of FOXC1 stability and transcriptional activity by an epidermal growth factor-activated mitogen-activated protein kinase signaling cascade. J Biol Chem. 2006;281:10098-104 pubmed
    Mutations in the FOXC1 transcription factor gene result in Axenfeld Rieger malformations, a disorder that affects the anterior segment of the eye, the teeth, and craniofacial structures...
  23. Mears A, Jordan T, Mirzayans F, Dubois S, Kume T, Parlee M, et al. Mutations of the forkhead/winged-helix gene, FKHL7, in patients with Axenfeld-Rieger anomaly. Am J Hum Genet. 1998;63:1316-28 pubmed
    ..Abnormalities of this locus lead to glaucoma. FKHL7 (also called "FREAC3"), a member of the forkhead/winged-helix transcription-factor family, has also been mapped to 6p25...
  24. Berry F, Saleem R, Walter M. FOXC1 transcriptional regulation is mediated by N- and C-terminal activation domains and contains a phosphorylated transcriptional inhibitory domain. J Biol Chem. 2002;277:10292-7 pubmed
    Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma...
  25. Zhou Y, Kato H, Asanoma K, Kondo H, Arima T, Kato K, et al. Identification of FOXC1 as a TGF-beta1 responsive gene and its involvement in negative regulation of cell growth. Genomics. 2002;80:465-72 pubmed
    We cloned the forkhead box C1 (FOXC1) gene, a member of the forkhead/winged-helix transcription factor family, as a transforming growth factor-beta1 (TGF-beta1) responsive gene...
  26. Komatireddy S, Chakrabarti S, Mandal A, Reddy A, Sampath S, Panicker S, et al. Mutation spectrum of FOXC1 and clinical genetic heterogeneity of Axenfeld-Rieger anomaly in India. Mol Vis. 2003;9:43-8 pubmed
    ..Axenfeld-Rieger anomaly (ARA) is a form of anterior segment dysgenesis of the eye, mainly caused by mutations in the FOXC1 gene. We had earlier reported a novel mutation in the wing region of FOXC1 in an autosomal dominant family...
  27. Cella W, de Vasconcellos J, de Melo M, Kneipp B, Costa F, Longui C, et al. Structural assessment of PITX2, FOXC1, CYP1B1, and GJA1 genes in patients with Axenfeld-Rieger syndrome with developmental glaucoma. Invest Ophthalmol Vis Sci. 2006;47:1803-9 pubmed
    ..The PITX2 gene, on chromosome 4q25, and the FOXC1 gene, on chromosome 6p25, have been implicated in the different phenotypes of the syndrome through mutational ..
  28. Saleem R, Murphy T, Liebmann J, Walter M. Identification and analysis of a novel mutation in the FOXC1 forkhead domain. Invest Ophthalmol Vis Sci. 2003;44:4608-12 pubmed
    ..b>FOXC1 was amplified from a proband with Axenfeld-Rieger malformations and the proband's mother...
  29. D Haene B, Meire F, Claerhout I, Kroes H, Plomp A, Arens Y, et al. Expanding the spectrum of FOXC1 and PITX2 mutations and copy number changes in patients with anterior segment malformations. Invest Ophthalmol Vis Sci. 2011;52:324-33 pubmed publisher
    ..The main purpose of this study was to assess the proportion of FOXC1 and PITX2 mutations and copy number changes in 80 probands with ASD...
  30. Sizemore S, Keri R. The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression. J Biol Chem. 2012;287:24631-40 pubmed publisher
    ..Recently, FOXC1, a forkhead box transcription factor, was identified as a functionally important biomarker of breast cancer ..
  31. Saleem R, Banerjee Basu S, Murphy T, Baxevanis A, Walter M. Essential structural and functional determinants within the forkhead domain of FOXC1. Nucleic Acids Res. 2004;32:4182-93 pubmed
    The forkhead domain (FHD)-containing developmental transcription factor FOXC1 is mutated in patients presenting with Axenfeld-Rieger malformations...
  32. Chakrabarti S, Kaur K, Rao K, Mandal A, Kaur I, Parikh R, et al. The transcription factor gene FOXC1 exhibits a limited role in primary congenital glaucoma. Invest Ophthalmol Vis Sci. 2009;50:75-83 pubmed publisher
    ..This study was conducted to explore the role of FOXC1, which is involved in anterior segment dysgenesis, in PCG...
  33. Lehmann O, Ebenezer N, Jordan T, Fox M, Ocaka L, Payne A, et al. Chromosomal duplication involving the forkhead transcription factor gene FOXC1 causes iris hypoplasia and glaucoma. Am J Hum Genet. 2000;67:1129-35 pubmed
    The forkhead transcription factor gene FOXC1 (formerly FKHL7) is responsible for a number of glaucoma phenotypes in families in which the disease maps to 6p25, although mutations have not been found in all families in which the disease ..
  34. Murphy T, Saleem R, Footz T, Ritch R, McGillivray B, Walter M. The wing 2 region of the FOXC1 forkhead domain is necessary for normal DNA-binding and transactivation functions. Invest Ophthalmol Vis Sci. 2004;45:2531-8 pubmed
    To determine the biochemical defects that underlie Axenfeld-Rieger malformations, to determine a functional role for wing 2 in FOXC1, and to understand how mutations in this region disrupt FOXC1 function.
  35. Mortemousque B, Amati Bonneau P, Couture F, Graffan R, Dubois S, Colin J, et al. Axenfeld-Rieger anomaly: a novel mutation in the forkhead box C1 (FOXC1) gene in a 4-generation family. Arch Ophthalmol. 2004;122:1527-33 pubmed
    ..DNA was tested for linkage to the IRID1 locus at chromosome 6p25, a known locus for ARA/Rieger syndrome...
  36. Visentin S, Vicentin D, Magrini G, Santandreu F, Disalvo L, Sala M, et al. Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. Early Hum Dev. 2016;100:11-5 pubmed publisher
    ..infant formulas based on cow milk fat, vegetable oils and different docosahexaenoic (DHA) and arachidonic (ARA) acid content on red blood cell membrane fatty acid composition, and determine the percent saturated fatty acid (..
  37. Weng X, Gaur G, Neethirajan S. Rapid Detection of Food Allergens by Microfluidics ELISA-Based Optical Sensor. Biosensors (Basel). 2016;6:24 pubmed publisher
    ..with a custom-designed optical sensor was developed for the quantitative analysis of the proteins wheat gluten and Ara h 1. The developed microfluidic ELISA biosensor reduced the total assay time from hours (up to 3...
  38. Fleckenstein Elsen M, Dinnies D, Jelenik T, Roden M, Romacho T, Eckel J. Eicosapentaenoic acid and arachidonic acid differentially regulate adipogenesis, acquisition of a brite phenotype and mitochondrial function in primary human adipocytes. Mol Nutr Food Res. 2016;60:2065-75 pubmed publisher
    ..were treated with n-3 PUFAs (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA) or n-6 PUFA (arachidonic acid, ARA) during differentiation, and adipogenesis, white and brite gene expression markers, mitochondrial content and ..
  39. Miller L, Jorgensen M, Kaplan J, Seeds M, Rahbar E, Morgan T, et al. Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav. 2016;156:71-8 pubmed publisher
    ..There was a marked reduction in the ratio of n-6 LC-PUFAs, arachidonic acid (ARA) and adrenic acid (ADR), relative to the n-3 LC-PUFA, docosahexaenoic acid (DHA), in temporal cortex lipids from ..
  40. Song M, Lim S, Wang J, Kim H. The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice. Int J Mol Sci. 2018;19: pubmed publisher
    ..previous studies, we found that the root of Atractylodes macrocephala Koidzumi (Atractylodis Rhizoma Alba, ARA) increased energy metabolism in C2C12 cells...
  41. Lewis C, Hedberg Buenz A, DeLuca A, Stone E, Alward W, Fingert J. Primary congenital and developmental glaucomas. Hum Mol Genet. 2017;26:R28-R36 pubmed publisher
    ..Axenfeld-Rieger syndrome is caused by mutations in PITX2 or FOXC1 and aniridia is caused by PAX6 mutations...
  42. Mao L, Lei J, Schoemaker M, Ma B, Zhong Y, Lambers T, et al. Long-chain polyunsaturated fatty acids and extensively hydrolyzed casein-induced browning in a Ucp-1 reporter mouse model of obesity. Food Funct. 2018;9:2362-2373 pubmed publisher
    ..Here, browning-inducing effects of long-chain polyunsaturated fatty acids, e.g., arachidonic acid (ARA)/docosahexaenoic acid (DHA) and extensively hydrolyzed casein (eHC) were investigated in uncoupling protein 1 (Ucp-..
  43. Sakoguchi H, Yoshihara A, Shintani T, Okuma K, Izumori K, Sato M. Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide. Bioorg Med Chem Lett. 2016;26:726-729 pubmed publisher
    ..Among these stereoisomers, the rare sugar D-arabinose (D-Ara) showed particularly strong growth inhibition. The IC50 value for D-Ara was estimated to be 7...
  44. Nian Q, Chi J, Xiao Q, Wei C, Costeas P, Yang Z, et al. SPARC ectopic overexpression inhibits growth and promotes programmed cell death in acute myeloid leukemia transformed from myelodysplastic syndrome cells, alone and in combination with Ara-C treatment. Oncol Rep. 2015;34:1406-14 pubmed publisher
    ..cells were then assessed for proliferation and cell death following treatment with low-dose cytosine arabinoside (Ara‑C)...
  45. Tan R, Markus H. Monogenic causes of stroke: now and the future. J Neurol. 2015;262:2601-16 pubmed publisher
    ..retinal vasculopathy with cerebral leukodystrophy, collagen type IV α1 and α2 gene-related arteriopathy and FOXC1 deletion related arteriopathy...
  46. Patil S, Ogunniyi A, Calatroni A, Tadigotla V, Ruiter B, Ma A, et al. Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J Allergy Clin Immunol. 2015;136:125-134.e12 pubmed publisher
    ..We used a fluorescent Ara h 2 multimer for affinity selection of Ara h 2-specific B cells and subsequent single-cell immunoglobulin ..
  47. Rhodes L, Martin E, Segar H, Miller D, Buechlein A, Rusch D, et al. Dual regulation by microRNA-200b-3p and microRNA-200b-5p in the inhibition of epithelial-to-mesenchymal transition in triple-negative breast cancer. Oncotarget. 2015;6:16638-52 pubmed
    ..Enhanced expression of genes associated with a mesenchymal transition includes ZEB1/2, TWIST, and FOXC1. miRNAs are known regulators of gene expression and altered miRNA expression is known to enhance EMT in breast ..
  48. Hu J, Hong X, Li Z, Lu Q. Acute monocytic leukaemia with t(11; 12) (p15; q13) chromosomal changes: A case report and literature review. Oncol Lett. 2015;10:2307-2310 pubmed
    ..5% of cells, and premonocytes accounted for 49.0%. This patient strongly responded to idarubicin and Ara-c (cytarabine) chemotherapy, which rapidly eliminated the leukaemia cell clones...
  49. Rad A, Eftestøl T, Irusta U, Kvaløy J, Wik L, Kramer Johansen J, et al. An automatic system for the comprehensive retrospective analysis of cardiac rhythms in resuscitation episodes. Resuscitation. 2018;122:6-12 pubmed publisher
    An automatic resuscitation rhythm annotator (ARA) would facilitate and enhance retrospective analysis of resuscitation data, contributing to a better understanding of the interplay between therapy and patient response...
  50. Hu Y, Sheng Y, Yu M, Li K, Ren G, Xu X, et al. Antioxidant activity of Inonotus obliquus polysaccharide and its amelioration for chronic pancreatitis in mice. Int J Biol Macromol. 2016;87:348-56 pubmed publisher
    ..3% and 81.3% respectively at a concentration of 5 mg/mL. IOP was composed of Man, Rha, Glu, Gal, Xyl and Ara in a molar ratio of 9.81:3.6:29.1:20.5:21.6:5.4 respectively...
  51. Sperr W, Herndlhofer S, Gleixner K, Girschikofsky M, Weltermann A, Machherndl Spandl S, et al. Intensive consolidation with G-CSF support: Tolerability, safety, reduced hospitalization, and efficacy in acute myeloid leukemia patients ?60 years. Am J Hematol. 2017;92:E567-E574 pubmed publisher
    ..study was to evaluate the efficacy and feasibility of intensified consolidation therapy employing fludarabine and ARA-C in cycle 1 and intermediate-dose ARA-C (IDAC) in cycles 2 through 4, in elderly acute myeloid leukemia (AML) ..
  52. Hopkins A, Coatham M, Berry F. FOXC1 Regulates FGFR1 Isoform Switching to Promote Invasion Following TGF?-Induced EMT. Mol Cancer Res. 2017;15:1341-1353 pubmed publisher
    ..Elevated expression of the FOXC1 transcription factor has been detected in several metastatic cancers that have undergone EMT...
  53. Martinez Glez V, Lorda Sanchez I, Ramirez J, Ruiz Barnes P, Rodriguez de Alba M, Diego Alvarez D, et al. Clinical presentation of a variant of Axenfeld-Rieger syndrome associated with subtelomeric 6p deletion. Eur J Med Genet. 2007;50:120-7 pubmed
    ..We describe a 6pter deletion detected by SNP genotyping and confirmed by FISH and MLPA involving the FOXC1 gene in a patient with ocular and systemic findings that fit perfectly with the variant mentioned above...
  54. Jensen T, RAY T, Wang J, Li X, Naritoku W, Han B, et al. Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay. J Natl Cancer Inst. 2015;107: pubmed publisher
    ..We postulated that elevated expression of Forkhead Box transcription factor C1 (FOXC1) is a simple and accurate diagnostic biomarker for BLBC...
  55. Qu Y, Zhang H, Zhang X, Jiang H. Arachidonic acid attenuates brain damage in a rat model of ischemia/reperfusion by inhibiting inflammatory response and oxidative stress. Hum Exp Toxicol. 2017;:960327117692134 pubmed publisher
    The aim of the present study was to study the effects of arachidonic acid (ARA) in a rat brain ischemia/reperfusion model induced by middle cerebral artery occlusion (MCAO)...
  56. Abaza Y, M Kantarjian H, Faderl S, Jabbour E, Jain N, Thomas D, et al. Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma. Am J Hematol. 2017;: pubmed publisher
    Nelarabine, a water soluble prodrug of 9-?-D-arabinofuranosylguanine (ara-G), is a T-cell specific purine nucleoside analogue...
  57. Guo Y, Yan S, Gong J, Jin L, Shi B. The Protective Effect of Selenium on Bovine Mammary Epithelial Cell Injury Caused by Depression of Thioredoxin Reductase. Biol Trace Elem Res. 2018;184:75-82 pubmed publisher
    ..our results indicated that Se treatment resulted in lower intracellular accumulation of arachidonic acid (ARA) and 15-hydroperoxyeicosatetraenoic acid (15-HPETE) due to suppressed expression of cytosolic phospholipase A2<..
  58. Park S, Jamshidi Y, Vaideanu D, Fraser S, Sowden J. Common TGF?2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma. Mol Vis. 2012;18:1526-39 pubmed
    ..An obvious group of genes to test as susceptibility factors for POAG are the developmental genes forkhead box C1 (FOXC1), transforming growth factor-beta 2 (TGF?2), and bone morphogenic protein 4 (BMP4)...
  59. Souzeau E, Siggs O, Zhou T, Galanopoulos A, Hodson T, Taranath D, et al. Glaucoma spectrum and age-related prevalence of individuals with FOXC1 and PITX2 variants. Eur J Hum Genet. 2017;25:839-847 pubmed publisher
    Variation in FOXC1 and PITX2 is associated with Axenfeld-Rieger syndrome, characterised by structural defects of the anterior chamber of the eye and a range of systemic features...
  60. Jordan T, Ebenezer N, Manners R, McGill J, Bhattacharya S. Familial glaucoma iridogoniodysplasia maps to a 6p25 region implicated in primary congenital glaucoma and iridogoniodysgenesis anomaly. Am J Hum Genet. 1997;61:882-8 pubmed
    ..This may indicate the presence of a common causative gene or, alternatively, a cluster of genes involved in eye development/function. ..
  61. Wei L, Zhou R, Xu H, Wang J, Yuan M. High expression of FOXC1 is associated with poor clinical outcome in non-small cell lung cancer patients. Tumour Biol. 2013;34:941-6 pubmed publisher
    The aim of this study was to detect FOXC1 expression in human non-small cell lung cancer (NSCLC) and to analyze its association with prognosis of NSCLC patients...
  62. Kim G, Ki C, Seo S, Yoo J, Han Y, Chung I, et al. A novel forkhead box C1 gene mutation in a Korean family with Axenfeld-Rieger syndrome. Mol Vis. 2013;19:935-43 pubmed
    To report a case series of patients with novel forkhead box CI (FOXC1) mutations in a Korean family with Axenfeld-Rieger syndrome (ARS).
  63. Pan F, Yao J, Chen Y, Zhou C, Geng P, Mao H, et al. A novel long non-coding RNA FOXCUT and mRNA FOXC1 pair promote progression and predict poor prognosis in esophageal squamous cell carcinoma. Int J Clin Exp Pathol. 2014;7:2838-49 pubmed
    ..Here, we showed that a novel long non-coding RNA FOXCUT (FOXC1 promoter upstream transcript) and its neighboring gene FOXC1 played a similar important role in the oncogenesis ..
  64. Wiggs J, Pasquale L. Genetics of glaucoma. Hum Mol Genet. 2017;26:R21-R27 pubmed publisher
    ..novel loci for POAG (primary-open-angle glaucoma) (ABCA1, AFAP1, GMDS, PMM2, TGFBR3, FNDC3B, ARHGEF12, GAS7, FOXC1, ATXN2, TXNRD2); PACG (primary angle-closure glaucoma (EPDR1, CHAT, GLIS3, FERMT2, DPM2-FAM102); and exfoliation ..
  65. Martin G, Chung S, Landrock D, Landrock K, Huang H, Dangott L, et al. FABP-1 gene ablation impacts brain endocannabinoid system in male mice. J Neurochem. 2016;138:407-22 pubmed publisher
    Liver fatty acid-binding protein (FABP1, L-FABP) has high affinity for and enhances uptake of arachidonic acid (ARA, C20:4, n-6) which, when esterified to phospholipids, is the requisite precursor for synthesis of endocannabinoids (EC) ..
  66. Chang J, Le K, Song X, Jiao K, Zeng X, Ling X, et al. Scale-up cultivation enhanced arachidonic acid accumulation by red microalgae Porphyridium purpureum. Bioprocess Biosyst Eng. 2017;40:1763-1773 pubmed publisher
    ..different scale-up conditions for further development and commercialization of microalgae-derived PUFAs such as ARA and EPA...
  67. van der Merwe E, Kidson S. Wholemount imaging reveals abnormalities of the aqueous outflow pathway and corneal vascularity in Foxc1 and Bmp4 heterozygous mice. Exp Eye Res. 2016;146:293-303 pubmed publisher
    Mutations in the FOXC1/Foxc1 gene in humans and mice and Bmp4 in mice are associated with congenital anterior segment dysgenesis (ASD) and the development of the aqueous outflow structures throughout the limbus...
  68. Han B, Qu Y, Jin Y, Yu Y, Deng N, Wawrowsky K, et al. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep. 2015;13:1046-58 pubmed publisher
    The mesoderm- and epithelial-mesenchymal transition-associated transcription factor FOXC1 is specifically overexpressed in basal-like breast cancer (BLBC), but its biochemical function is not understood...
  69. Berker N, Alanay Y, Elgin U, Volkan Salanci B, Simsek T, Akarsu N, et al. A new autosomal dominant Peters' anomaly phenotype expanding the anterior segment dysgenesis spectrum. Acta Ophthalmol. 2009;87:52-7 pubmed publisher
    ..family with PA were extensively phenotyped and linkage analysis of candidate genes, namely, PAX6, PITX2, FOXC1, CYP1B1 and MAF, was performed. The complete pedigree consisted of 38 members, 19 of whom were affected...
  70. Yang H, Lee Y, Joo C, Moon J, Mok J, Park M. A Family with Axenfeld-Rieger Syndrome: Report of the Clinical and Genetic Findings. Korean J Ophthalmol. 2015;29:249-55 pubmed publisher
    ..1362_1364insCGG and c.1142_1144insGGC were identified in forkhead box C1 in four affected family members. This study may help to understand clinical findings and prognosis for patients with Axenfeld-Rieger syndrome. ..