Gene Symbol: follistatin
Description: follistatin
Alias: follistatin, activin-binding protein, follistatin isoform FST317
Species: human
Products:     follistatin

Top Publications

  1. Shimonaka M, Inouye S, Shimasaki S, Ling N. Follistatin binds to both activin and inhibin through the common subunit. Endocrinology. 1991;128:3313-5 pubmed
    Inhibin, activin, and follistatin are three families of polypeptides originally isolated and characterized from ovarian follicular fluid based on their modulation of FSH release from pituitary cell culture...
  2. Phillips D, de Kretser D. Follistatin: a multifunctional regulatory protein. Front Neuroendocrinol. 1998;19:287-322 pubmed
    b>Follistatin was first described in 1987 as a follicle-stimulating hormone inhibiting substance present in ovarian follicular fluid...
  3. Sidis Y, Mukherjee A, Keutmann H, Delbaere A, Sadatsuki M, Schneyer A. Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. Endocrinology. 2006;147:3586-97 pubmed
    b>Follistatin (FST) and FST-like-3 (FSTL3) are activin-binding and neutralization proteins that also bind myostatin...
  4. Petraglia F, Gallinelli A, Grande A, Florio P, Ferrari S, Genazzani A, et al. Local production and action of follistatin in human placenta. J Clin Endocrinol Metab. 1994;78:205-10 pubmed
    The aim of the present study was to investigate the possible production, localization, and action of follistatin in human placenta, fetal membranes (amnion, chorion), and maternal decidua...
  5. Schneyer A, Hall H, Lambert Messerlian G, Wang Q, Sluss P, Crowley W. Follistatin-activin complexes in human serum and follicular fluid differ immunologically and biochemically. Endocrinology. 1996;137:240-7 pubmed
    b>Follistatin (FS) is the principle high affinity activin-binding protein in tissues such as the pituitary and ovary as well as in serum...
  6. Bartholin L, Maguer Satta V, Hayette S, Martel S, Gadoux M, Corbo L, et al. Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function. Oncogene. 2002;21:2227-35 pubmed
    Signaling of TGFbeta family members such as activin is tightly regulated by soluble binding proteins. Follistatin binds to activin A with high affinity, and prevents activin binding to its own receptors, thereby blocking its signaling...
  7. Blount A, Schmidt K, Justice N, Vale W, Fischer W, Bilezikjian L. FoxL2 and Smad3 coordinately regulate follistatin gene transcription. J Biol Chem. 2009;284:7631-45 pubmed publisher
    b>Follistatin is a transcriptional target and a modulator of activin action. Through an autocrine/paracrine loop, activin controls follistatin levels and thus regulates its own bioavailability...
  8. Tumminello F, Badalamenti G, Fulfaro F, Incorvaia L, Crescimanno M, Flandina C, et al. Serum follistatin in patients with prostate cancer metastatic to the bone. Clin Exp Metastasis. 2010;27:549-55 pubmed publisher
    The clinical significance of circulating follistatin (FLST), an inhibitor of the multifunctional cytokine activin A (Act A), was investigated in patients with prostate cancer (PCa)...
  9. Sumitomo S, Inouye S, Liu X, Ling N, Shimasaki S. The heparin binding site of follistatin is involved in its interaction with activin. Biochem Biophys Res Commun. 1995;208:1-9 pubmed
    Whether the heparin-binding site of follistatin would interact with activin has been examined...

More Information

Publications117 found, 100 shown here

  1. Hashimoto O, Tsuchida K, Ushiro Y, Hosoi Y, Hoshi N, Sugino H, et al. cDNA cloning and expression of human activin betaE subunit. Mol Cell Endocrinol. 2002;194:117-22 pubmed
    ..We also found that the human activin betaE protein could bind to follistatin, an activin-binding protein...
  2. Schneyer A, Schoen A, Quigg A, Sidis Y. Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3/FSRP/FLRG). Endocrinology. 2003;144:1671-4 pubmed
    Modulation of activin and other TGF beta superfamily signaling is the primary mechanism of action for both follistatin (FS) and FS-like 3 (FSTL-3). However, most studies of these ligands use activin A due to its wide availability...
  3. Ogino H, Yano S, Kakiuchi S, Muguruma H, Ikuta K, Hanibuchi M, et al. Follistatin suppresses the production of experimental multiple-organ metastasis by small cell lung cancer cells in natural killer cell-depleted SCID mice. Clin Cancer Res. 2008;14:660-7 pubmed publisher
    b>Follistatin (FST), an inhibitor of activin, regulates a variety of biological functions, including cell proliferation, differentiation, and apoptosis. However, the role of FST in cancer metastasis is still unknown...
  4. Bloise E, Couto H, Massai L, Ciarmela P, Mencarelli M, Borges L, et al. Differential expression of follistatin and FLRG in human breast proliferative disorders. BMC Cancer. 2009;9:320 pubmed publisher
    ..b>Follistatin and follistatin- related gene (FLRG) bind and neutralize activins...
  5. Shimasaki S, Koga M, Esch F, Cooksey K, Mercado M, Koba A, et al. Primary structure of the human follistatin precursor and its genomic organization. Proc Natl Acad Sci U S A. 1988;85:4218-22 pubmed
    b>Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release...
  6. Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer Satta V, Rimokh R, et al. Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma. Eur J Endocrinol. 2004;151:251-7 pubmed
    ..In the present study we evaluated the expression of two inhibitory activin A ligands, follistatin and follistatin-related gene (FLRG), in endometrial adenocarcinoma and in age-matched healthy human endometrium...
  7. Torres P, Florio P, Ferreira M, Torricelli M, Reis F, Petraglia F. Deranged expression of follistatin and follistatin-like protein in women with ovarian endometriosis. Fertil Steril. 2007;88:200-5 pubmed
    To evaluate the messenger RNA (mRNA) expression and peptide localization of follistatin and follistatin-like protein (FLRG) in ovarian endometriosis, compared to healthy human endometrium...
  8. Michel U, Ebert S, Phillips D, Nau R. Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia. Eur J Endocrinol. 2003;148:559-64 pubmed
    ..Clinical data linking activin and its binding protein, follistatin (FS), are lacking. We measured serum levels of activin and FS in patients diagnosed with septicemia...
  9. Saito S, Sidis Y, Mukherjee A, Xia Y, Schneyer A. Differential biosynthesis and intracellular transport of follistatin isoforms and follistatin-like-3. Endocrinology. 2005;146:5052-62 pubmed
    b>Follistatin (FST) and FST-like-3 (FSTL3) are structurally related proteins that bind and neutralize activin and closely related members of the TGFbeta superfamily...
  10. Gao X, Hu H, Zhu J, Xu Z. Identification and characterization of follistatin as a novel angiogenin-binding protein. FEBS Lett. 2007;581:5505-10 pubmed
    ..In this study, follistatin was identified as a binding partner of angiogenin by a yeast two-hybrid screen and confirmed by a pull-down ..
  11. Flanagan J, Linder K, Mejhert N, Dungner E, Wahlen K, Decaunes P, et al. Role of follistatin in promoting adipogenesis in women. J Clin Endocrinol Metab. 2009;94:3003-9 pubmed publisher
    b>Follistatin is a glycoprotein that binds and neutralizes biological activities of TGFbeta superfamily members including activin and myostatin...
  12. Mehta N, Zhang D, Li R, Wang T, Gava A, Parthasarathy P, et al. Caveolin-1 regulation of Sp1 controls production of the antifibrotic protein follistatin in kidney mesangial cells. Cell Commun Signal. 2019;17:37 pubmed publisher regulating matrix production, we had identified significant upregulation of the antifibrotic protein follistatin in cav-1 knockout MC...
  13. Omar N, Rashed R, El Hazek R, El Sabbagh W, Rashed E, El Ghazaly M. Platelet-rich plasma-induced feedback inhibition of activin A/follistatin signaling: A mechanism for tumor-low risk skin rejuvenation in irradiated rats. J Photochem Photobiol B. 2018;180:17-24 pubmed publisher
    ..malignancies in light of the cross-talk between PRP and activin A type II receptors (ActR-IIA)/follistatin (FST) signaling pathways where the inflammatory responses at 2 different time points were evaluated...
  14. George L, Mitra A, Thimraj T, Irmler M, Vishweswaraiah S, Lunding L, et al. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017;18:152 pubmed publisher
    ..Noteworthy genes selected as candidates for their consistent expression include: Wnt inhibitor factor 1 (Wif1), follistatin (Fst), chitinase-like 1 (Chil1), and Chil3...
  15. Su H, Liao J, Wang Y, Chen K, Lin C, Lee I, et al. Exogenous GDF11 attenuates non-canonical TGF-β signaling to protect the heart from acute myocardial ischemia-reperfusion injury. Basic Res Cardiol. 2019;114:20 pubmed publisher
    ..Notably, pretreatment with the activin-binding protein, follistatin (FST), inhibited the cardioprotective effects of GDF11 by blocking its activation of Smad2/3 signaling and its ..
  16. Boerboom D, Kumar V, Boyer A, Wang Y, Lambrot R, Zhou X, et al. β-catenin stabilization in gonadotropes impairs FSH synthesis in male mice in vivo. Endocrinology. 2015;156:323-33 pubmed publisher
    ..This selective regulation of FSH suggested an alteration in the activin/inhibin/follistatin system...
  17. Nicolas N, Muir J, Hayward S, Chen J, Stanton P, Gregorevic P, et al. Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin. Reproduction. 2017;154:293-305 pubmed publisher
    ..Consequently, we examined the development of EAO in mice with elevated levels of follistatin, an endogenous activin antagonist, as a potential therapeutic approach to testicular inflammation...
  18. Kong B, Hudson N, Seo D, Lee S, Khatri B, Lassiter K, et al. RNA sequencing for global gene expression associated with muscle growth in a single male modern broiler line compared to a foundational Barred Plymouth Rock chicken line. BMC Genomics. 2017;18:82 pubmed publisher
    ..Upstream and network analyses revealed that the MSTN (myostatin) -FST (follistatin) interactions and inhibition of AR (androgen receptor) were predicted to be effective regulatory factors for DE ..
  19. Kalinkovich A, Livshits G. Sarcopenia--The search for emerging biomarkers. Ageing Res Rev. 2015;22:58-71 pubmed publisher
    ..of muscle growth such as bone morphogenetic proteins (BMPs), brain-derived neurotrophic factor (BDNF), follistatin (FST) and irisin, and negative regulators including TGFβ, myostatin, activins A and B, and growth and ..
  20. Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk M, Schneyer A. Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity. Am J Physiol Endocrinol Metab. 2012;303:E587-96 pubmed publisher
    ..However, BBKO islets were more sensitive to activin A, myostatin (MSTN), and follistatin (FST) treatments, so that activin A and FST inhibited and MSTN enhanced glucose stimulated insulin secretion...
  21. O Connell A, McNatty K, Hurst P, Spencer T, Bazer F, Reader K, et al. Activin A and follistatin during the oestrous cycle and early pregnancy in ewes. J Endocrinol. 2016;228:193-203 pubmed publisher
    ..Therefore, the aim of the current study was to determine whether the concentrations of activin A and follistatin (FST), an activin-binding protein, differed between ewes with a lifetime history of enhanced or reduced ..
  22. Fortin J, Ongaro L, Li Y, Tran S, Lamba P, Wang Y, et al. Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?. Mol Endocrinol. 2015;29:963-77 pubmed publisher
    ..activins also stimulate the transcription of the GnRH receptor (Gnrhr) and the activin antagonist, follistatin (Fst)...
  23. Zhao C, Qiao C, Tang R, Jiang J, Li J, Martin C, et al. Overcoming Insulin Insufficiency by Forced Follistatin Expression in β-cells of db/db Mice. Mol Ther. 2015;23:866-874 pubmed publisher
    ..We describe a therapeutic strategy to preserve β-cell function by overexpression of follistatin (FST) using an AAV vector (AAV8-Ins-FST) in diabetic mouse model...
  24. Cash J, Angerman E, Kattamuri C, Nolan K, Zhao H, Sidis Y, et al. Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. J Biol Chem. 2012;287:1043-53 pubmed publisher
    ..One form of regulation is through inhibition by extracellular antagonists such as the follistatin (Fst)-type proteins...
  25. Wang Z, Niu W, Wang Y, Teng Z, Wen J, Xia G, et al. Follistatin288 Regulates Germ Cell Cyst Breakdown and Primordial Follicle Assembly in the Mouse Ovary. PLoS ONE. 2015;10:e0129643 pubmed publisher
    ..The role of FST288, the strongest ACT-neutralizing isoform of follistatin (FST), during cyst breakdown and primordial follicle formation in the fetal mice ovary was assessed using an in ..
  26. Zhang L, Liu K, Han B, Xu Z, Gao X. The emerging role of follistatin under stresses and its implications in diseases. Gene. 2018;639:111-116 pubmed publisher
    b>Follistatin (FST), a single-chain glycosylated protein, is expressed in various tissues...
  27. Kusama K, Bai R, Ideta A, Aoyagi Y, Okuda K, Imakawa K. Regulation of epithelial to mesenchymal transition in bovine conceptuses through the interaction between follistatin and activin A. Mol Cell Endocrinol. 2016;434:81-92 pubmed publisher
    ..The iTRAQ analysis demonstrated that follistatin (FST), an inhibitor of activin A, increased in P20 UF...
  28. Budzynska B, Michalak A, Frankowska M, Kaszubska K, Biała G. Acute behavioral effects of co-administration of mephedrone and MDMA in mice. Pharmacol Rep. 2017;69:199-205 pubmed publisher
  29. Johansson M, Quintela M, Laurila A. Genetic divergence and isolation by thermal environment in geothermal populations of an aquatic invertebrate. J Evol Biol. 2016;29:1701-12 pubmed publisher
    ..Our results emphasize the influence of environmental temperature on the genetic structure of populations and suggest local thermal adaptation in these geothermal habitats. ..
  30. Afsar T, Razak S, Khan M, Almajwal A. Anti-depressant and anxiolytic potential of Acacia hydaspica R. Parker aerial parts extract: Modulation of brain antioxidant enzyme status. BMC Complement Altern Med. 2017;17:228 pubmed publisher
    ..hydaspica. The present study revealed that A. hydaspica exerts an antidepressant and anxiolytic effect by improving brain antioxidant status. The observed activities might be due to the presence of diverse phytochemicals. ..
  31. Liu Y, Zhou X, Yang L, Wang H, Zhang Y, Pu J, et al. Social defeat stress causes depression-like behavior with metabolite changes in the prefrontal cortex of rats. PLoS ONE. 2017;12:e0176725 pubmed publisher
    ..Particularly, lipid metabolism, amino acid metabolism, and energy metabolism were significantly perturbed. The results of this study suggest that repeated social defeat can lead to metabolic changes and depression-like behavior in rats. ..
  32. Li Y, Liu X, Chen Z, Song D, Yang J, Zuo X, et al. Effect of follistatin on pre-implantational development of pig parthenogenetic embryos. Anim Sci J. 2017;: pubmed publisher
    The present study was designed to explore effects of follistatin (FST) on pre-implantational development of parthenogenetically activated embryos (PAEs) in pigs...
  33. Qi C, Shu Y, Chen F, Ding Y, Zhou J. Sensitivity during the forced swim test is a key factor in evaluating the antidepressant effects of abscisic acid in mice. Behav Brain Res. 2016;300:106-13 pubmed publisher
    ..Our results show that ABA has antidepressant effects in SIM substrain and suggest that mice with learned helplessness might be more suitable for screening potential antidepressant drugs. ..
  34. Collison F, Park J, Fishman G, McAnany J, Stone E. Full-Field Pupillary Light Responses, Luminance Thresholds, and Light Discomfort Thresholds in CEP290 Leber Congenital Amaurosis Patients. Invest Ophthalmol Vis Sci. 2015;56:7130-6 pubmed publisher
    ..The LDT elevations for the patients are somewhat paradoxical, given their subjective perception of photoaversion. Relative aversion to short-wavelength light suggests influence from melanopsin on LDTs in these patients. ..
  35. Khammanivong A, Sorenson B, Ross K, Dickerson E, Hasina R, Lingen M, et al. Involvement of calprotectin (S100A8/A9) in molecular pathways associated with HNSCC. Oncotarget. 2016;7:14029-47 pubmed publisher
    ..Our findings strongly suggest that downregulation of S100A8/A9 through epigenetic mechanisms may contribute to increased proliferation, malignant transformation, and disease progression in HNSCC. ..
  36. Li Y, Wang Y, Xuan C, Li Y, Piao L, Li J, et al. Role of the Lateral Habenula in Pain-Associated Depression. Front Behav Neurosci. 2017;11:31 pubmed publisher
    ..Furthermore, we showed that increases in the LHb-DRN pathway activity were a common neurobiological mechanisms for pain and depression, which may explain the coexistence of pain and depression. ..
  37. Yang X, Lou H, Sun J, Zhu Y, Xue X, Hong X. Temporal Genetic Dynamics of an Invasive Species, Frankliniella occidentalis (Pergande), in an Early Phase of Establishment. Sci Rep. 2015;5:11877 pubmed publisher
    ..Our results showed that the invasive populations of F. occidentalis in China can maintain temporal stability in genetic composition at an early phase of establishment despite having lower genetic diversity than in their native range. ..
  38. Gutierrez A, Yáñez J, Davidson W. Evidence of recent signatures of selection during domestication in an Atlantic salmon population. Mar Genomics. 2016;26:41-50 pubmed publisher
    ..This study provides clear evidence of the presence of signatures of selection and domestication in a farmed Atlantic salmon population. ..
  39. Nakamura T, Jimenez Rojo L, Koyama E, Pacifici M, de Vega S, Iwamoto M, et al. Epiprofin Regulates Enamel Formation and Tooth Morphogenesis by Controlling Epithelial-Mesenchymal Interactions During Tooth Development. J Bone Miner Res. 2017;32:601-610 pubmed publisher
    ..By contrast, ameloblasts and enamel were found only on the labial side in wild-type mice, as Follistatin (Fst) expressed in the lingual side inhibits BMP4 signaling necessary for ameloblast differentiation...
  40. Li M, Jiang Z, Song L, Quan Z, Yu H. Antidepressant and anxiolytic-like behavioral effects of erucamide, a bioactive fatty acid amide, involving the hypothalamus-pituitary-adrenal axis in mice. Neurosci Lett. 2017;640:6-12 pubmed publisher
  41. Reis F, Luisi S, Abrao M, Rocha A, Vigano P, Rezende C, et al. Diagnostic value of serum activin A and follistatin levels in women with peritoneal, ovarian and deep infiltrating endometriosis. Hum Reprod. 2012;27:1445-50 pubmed publisher
    Activin A is a growth factor, produced by the endometrium, whose actions are modulated by the binding protein follistatin. Both proteins are detectable in the peripheral serum and their concentrations may be increased in women with ..
  42. Zhu J, Yu D, Xu X. The phylogeographic structure of Hydrilla verticillata (Hydrocharitaceae) in China and its implications for the biogeographic history of this worldwide-distributed submerged macrophyte. BMC Evol Biol. 2015;15:95 pubmed publisher
    ..Our findings also provide useful information for the management of invasive Hydrilla in North America. ..
  43. Malyarchuk B, Litvinov A, Derenko M, Skonieczna K, Grzybowski T, Grosheva A, et al. Mitogenomic diversity in Russians and Poles. Forensic Sci Int Genet. 2017;30:51-56 pubmed publisher
    ..3kya (95% CI: 2.9-5.8kya), i.e. in the Bronze Age. This expansion strongly correlates with the Kurgan model established by archaeologists and confirmed by paleogeneticists. ..
  44. Datta Mannan A, Yaden B, Krishnan V, Jones B, Croy J. An engineered human follistatin variant: insights into the pharmacokinetic and pharmocodynamic relationships of a novel molecule with broad therapeutic potential. J Pharmacol Exp Ther. 2013;344:616-23 pubmed publisher
    Human follistatin is a regulatory glycoprotein with widespread biologic functions, including antiinflammatory activities, wound-healing properties, and muscle-stimulating effects...
  45. Jastrzębska Więsek M, Siwek A, Partyka A, Szewczyk B, Sowa Kućma M, Wasik A, et al. Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1079-88 pubmed publisher
    ..The obtained findings suggest that EMD 386088 produces antidepressant-like activity after systemic acute and chronic administration which may result from direct stimulation of 5-HT6 receptors. ..
  46. Francuski L, Milankov V, Ludoški J, Krtinić B, Lundström J, Kemenesi G, et al. Genetic and phenotypic variation in central and northern European populations of Aedes (Aedimorphus) vexans (Meigen, 1830) (Diptera, Culicidae). J Vector Ecol. 2016;41:160-71 pubmed publisher
    ..vexans. We discussed data considering population structure in the light of vector control strategies of the mosquito from public health importance. ..
  47. Siddiqui P, Khan A, Uddin N, Khaliq S, Rasheed M, Nawaz S, et al. Antidepressant-like deliverables from the sea: evidence on the efficacy of three different brown seaweeds via involvement of monoaminergic system. Biosci Biotechnol Biochem. 2017;81:1369-1378 pubmed publisher
    ..It may be concluded that the extracts of SS, SM, and NZ produces antidepressant-like activity via modulation of brain monoaminergic system in a rat model. ..
  48. Wang G, He Z, Zhu H, Gao Y, Zhao Y, Yang H, et al. Involvement of serotonergic, noradrenergic and dopaminergic systems in the antidepressant-like effect of ginsenoside Rb1, a major active ingredient of Panax ginseng C.A. Meyer. J Ethnopharmacol. 2017;204:118-124 pubmed publisher
  49. Falcon E, Browne C, Leon R, Fleites V, Sweeney R, Kirby L, et al. Antidepressant-like Effects of Buprenorphine are Mediated by Kappa Opioid Receptors. Neuropsychopharmacology. 2016;41:2344-51 pubmed publisher
    ..The KOR was identified as a key player mediating the effects of BPN in tests sensitive to antidepressant drugs in mice. These studies support further development of BPN as a novel antidepressant. ..
  50. Muñoz N, Qi X, Li M, Xie M, Gao Y, Cheung M, et al. Improvement in nitrogen fixation capacity could be part of the domestication process in soybean. Heredity (Edinb). 2016;117:84-93 pubmed publisher
  51. Ishola I, Akinleye M, Oduola M, Adeyemi O. Roles of monoaminergic, antioxidant defense and neuroendocrine systems in antidepressant-like effect of Cnestis ferruginea Vahl ex DC (Connaraceae) in rats. Biomed Pharmacother. 2016;83:340-348 pubmed publisher
    ..These results suggest that the antidepressant-like effect of C. ferruginea involved enhancement of monoamines and antioxidant as well as normalization of neuroendocrine systems. ..
  52. Tao L, Huang M, Saroj Thapa -, Wang J, Wu S, He F, et al. Effects of macrophage migration inhibitory factor on cardiac reperfusion injury in mice with depression induced by constant-darkness. J Affect Disord. 2018;229:403-409 pubmed publisher
    ..05). DD-induced depression might cause decreased expression of MIF in the heart, resulting in downregulation of MIF-AMPK signaling and a subsequent adverse outcome after a cardiac I/R injury. ..
  53. Urbanek M, Legro R, Driscoll D, Azziz R, Ehrmann D, Norman R, et al. Thirty-seven candidate genes for polycystic ovary syndrome: strongest evidence for linkage is with follistatin. Proc Natl Acad Sci U S A. 1999;96:8573-8 pubmed
    ..The strongest evidence for linkage was with the follistatin gene, for which affected sisters showed increased identity by descent (72%; chi(2) = 12.97; nominal P = 3...
  54. Muzio L, Brambilla V, Calcaterra L, D Adamo P, Martino G, Benedetti F. Increased neuroplasticity and hippocampal microglia activation in a mice model of rapid antidepressant treatment. Behav Brain Res. 2016;311:392-402 pubmed publisher
    ..Increased Arc/Arg3.1 suggests however increased neuroplasticity, which could be common to all fast-acting antidepressants, and possibly occurring in other brain areas. ..
  55. Jiang N, Fan L, Yang Y, Liu X, Lin H, Gao L, et al. [Antidepressant effects of the extract of Dendrobium nobile Lindl on chronic unpredictable mild stress-induced depressive mice]. Sheng Li Xue Bao. 2017;69:159-166 pubmed
    ..01). These findings indicate that the extract of DNL has an antidepressant-like effect on CUMS-induced depressive mice and its mechanism may be related to the changes in DA and 5-HT in the hippocampus and cortex. ..
  56. Frezzetti D, Gallo M, Roma C, D Alessio A, Maiello M, Bevilacqua S, et al. Vascular Endothelial Growth Factor A Regulates the Secretion of Different Angiogenic Factors in Lung Cancer Cells. J Cell Physiol. 2016;231:1514-21 pubmed publisher
    ..of VEGFA itself but also significantly induced the secretion of a variety of angiogenic factors, including follistatin (FST), hepatocyte growth factor (HGF), angiopoietin-2 (ANGPT2), granulocyte-colony stimulating factor (G-CSF), ..
  57. Yanagida S, Motomura K, Ohashi A, Hiraoka K, Miura T, Kanba S. Effect of acute imipramine administration on the pattern of forced swim-induced c-Fos expression in the mouse brain. Neurosci Lett. 2016;629:119-124 pubmed publisher
    ..The present results suggest that the activation of several regions in the lateral septum and the hypothalamus underlies antidepressant-like effect in the mouse FST. ..
  58. Sorbolini S, Gaspa G, Steri R, Dimauro C, Cellesi M, Stella A, et al. Use of canonical discriminant analysis to study signatures of selection in cattle. Genet Sel Evol. 2016;48:58 pubmed publisher
    ..The genes that were highlighted in the canonical discriminant analysis were in concordance with those obtained using the FST index. ..
  59. Ostadhadi S, Akbarian R, Norouzi Javidan A, Nikoui V, Zolfaghari S, Chamanara M, et al. Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effects of gabapentin in mouse forced swimming test. Can J Physiol Pharmacol. 2017;95:795-802 pubmed publisher
    ..None of the treatments had any impact on the locomotor movement. Our study, for the first time, revealed that antidepressant-like effect of gabapentin in mice is mediated by blocking the KATP channels. ..
  60. Maina F, Bouchet S, Marla S, Hu Z, Wang J, Mamadou A, et al. Population genomics of sorghum (Sorghum bicolor) across diverse agroclimatic zones of Niger. Genome. 2018;: pubmed publisher
    ..These findings could facilitate genomics-assisted breeding of locally-adapted and farmer-preferred sorghum varieties for Niger. ..
  61. Yao Y, Zhao W, Shang X. Development of polymorphic microsatellite markers of Obolodiplosis robiniae (Haldeman) (Diptera: Cecidomyiidae), a North American pest invading Asia. J Insect Sci. 2015;15: pubmed publisher
    ..These markers represent a useful tool to design strategies for integrated pest management and in the study of population evolution in this important introduced pest. ..
  62. Sun W, Dong H, Gao Y, Su Q, Qian H, Bai H, et al. Genetic variation and geographic differentiation among populations of the nonmigratory agricultural pest Oedaleus infernalis (Orthoptera: Acridoidea) in China. J Insect Sci. 2015;15: pubmed publisher
    ..No significant correlation was found between the genetic distance and geographical distance. Overall, our results suggest that the geographical distance plays an unimpeded role in the gene flow among O. infernalis populations. ..
  63. Pesarico A, Stangherlin E, Rosa S, Mantovani A, Zeni G, Nogueira C. Contribution of NMDA, GABAA and GABAB receptors and l-arginine-NO-cGMP, MEK1/2 and CaMK-II pathways in the antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice. Eur J Pharmacol. 2016;782:6-13 pubmed publisher
    ..The results suggest a contribution of NMDA, GABAA and GABAB receptors and l-arginine-NO-cGMP pathway in the antidepressant-like action of FDPI in mice, and this effect is related to CaMK-II and MEK 1/2 activation. ..
  64. Bonilla Jaime H, Guadarrama Cruz G, Alarcon Aguilar F, Limón Morales O, Vazquez Palacios G. Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. J Nat Med. 2015;69:463-70 pubmed publisher
    ..lucida could be modulating the release/reuptake of serotonin. ..
  65. Gonzalez Aldaco K, Rebello Pinho J, Roman S, Gleyzer K, Fierro N, Oyakawa L, et al. Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico. PLoS ONE. 2016;11:e0146258 pubmed publisher
    ..The T/G/ΔG high-risk haplotype predominated in Amerindians and the beneficial alternative haplotype in Mestizos. The C/T/TT haplotype was associated with SC and less liver damage in chronically infected Mestizo patients. ..
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    ..Thus, it is assumed that the antidepressant activity of liquiritigenin might be attributed to its anti-inflammatory property and BDNF/TrkB signaling pathway. ..
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    We examined associations among myostatin (MSTN) 2379 A > G and 163 G > A and follistatin (FST) -5003 A > T and -833 G > T single nucleotide polymorphisms (SNP) on the muscle size and the strength response to resistance ..
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    ..Thus, it was supposed that liquiritigenin might be useful for the treatment of chronic depression possibly through PI3K/Akt/mTOR mediated BDNF/TrkB pathway. ..
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    ..Concluding, FSL rats present with cognitive deficits and depressive-like behaviors that are reversed by acute and chronic GM treatment, similar to that of IMI. ..
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    ..In summary, our data suggest that integrin alpha6beta4 confers a motile and invasive phenotype to breast carcinoma cells by regulating proinvasive and prometastatic gene expression. ..
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    b>Follistatin levels have recently been considered as a marker for inflammation...
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    ..The antidepressant-like effects seen with the 5-HT1A agonist alone treatment in FSL but not in SD rats may instead involve significant increases in the FGFR1-5-HT1A complexes of the CA2 and CA3 areas of the hippocampus...
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    The Activin A-Follistatin system has emerged as an important regulator of lipid and glucose metabolism with possible repercussions on fetal growth...
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    ..Our results suggest that distinct properties in regulation of mTOR phosphorylation and synaptic protein expression may underlie the differential effectiveness of ketamine and memantine in their antidepressant responses. ..
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    b>Follistatin (FST), which was first found in the follicles of cattle and pigs, has been shown to be an essential regulator for muscle development...
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    ..Pairwise genetic differences Fst values (-0.00091 to 0.05873) and the analysis by STRUCTURE indicated that Chinese populations have good internal consistency. ..
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    ..In addition, both positive artificial selection and the relaxation of functional constraints appeared to play important roles in the degeneration of flyability in domestic geese. ..
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    ..Variation of these F-statistics is small and even minimized for FST under Wahlund effects as compared to null alleles. I finally propose a determination key to interpret data with heterozygote deficits...
  86. Bondestam J, Horelli Kuitunen N, Hilden K, Ritvos O, Aaltonen J. Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. Cytogenet Cell Genet. 1999;87:219-20 pubmed
  87. Zhang X, Wang L, Xiong L, Huang F, Xue H. Timosaponin B-III exhibits antidepressive activity in a mouse model of postpartum depression by the regulation of inflammatory cytokines, BNDF signaling and synaptic plasticity. Exp Ther Med. 2017;14:3856-3861 pubmed publisher
    ..01). Thus, TB-III exhibited a protective effect against depression in PPD and such effects may have been mediated via the regulation of inflammatory cytokines, the BNDF signaling pathway and synaptic plasticity-related proteins...
  88. Zabkiewicz C, Resaul J, Hargest R, Jiang W, Ye L. Increased Expression of Follistatin in Breast Cancer Reduces Invasiveness and Clinically Correlates with Better Survival. Cancer Genomics Proteomics. 2017;14:241-251 pubmed
    Activin and its antagonist follistatin (FST) have been implicated in several solid tumours. This study investigated the role of FST in breast cancer...
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    ..Our findings provide a genome-wide selection signature draft for DB and SF, and establish a resource that can be exploited in chicken breeding programs to manipulate the genes that underlie desired phenotypes...
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    ..None of the treatments affected locomotor activity in open field test (OFT). These results together, suggest that the SeTACN antidepressant-like effect is mediate, at least in parts, by serotonergic system...
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    ..Our goal was to determine the spatial and temporal expression of inhibin/activin subunits; the binding protein, follistatin; and activin receptors in the human fetal palate...
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    ..Intracerebroventricular infusion of RvD1 or RvD2 did not affect locomotor activity. These results demonstrate that RvD1 and RvD2 produce rapid and sustained antidepressant effects in the CUS model. ..