Gene Symbol: FNBP1L
Description: formin binding protein 1 like
Alias: C1orf39, TOCA1, formin-binding protein 1-like, toca-1, transducer of Cdc42-dependent actin assembly 1, transducer of Cdc42-dependent actin assembly protein 1
Species: human
Products:     FNBP1L

Top Publications

  1. Ho H, Rohatgi R, Lebensohn A, Li J, Gygi S, Kirschner M. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 2004;118:203-16 pubmed publisher
    ..These findings represent a significantly revised view of Cdc42-signaling and shed light on the pathogenesis of Wiskott-Aldrich syndrome...
  2. Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol. 2006;172:269-79 pubmed
    ..Furthermore, knockdown of endogenous FBP17 and CIP4 impaired endocytosis. Our data indicate that PCH protein family members couple membrane deformation to actin cytoskeleton reorganization in various cellular processes. ..
  3. Bu W, Chou A, Lim K, Sudhaharan T, Ahmed S. The Toca-1-N-WASP complex links filopodial formation to endocytosis. J Biol Chem. 2009;284:11622-36 pubmed publisher
    ..Taken together, these data suggest that the Toca-1-N-WASP complex can link filopodial formation to endocytosis. ..
  4. Hu J, Mukhopadhyay A, Craig A. Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness. J Biol Chem. 2011;286:2261-72 pubmed publisher
    ..Taken together, these results implicate Toca-1 in coordinating actin assembly within filopodia and lamellipodia to promote EGF-induced cell migration and invasion. ..
  5. Giuliani C, Troglio F, Bai Z, Patel F, Zucconi A, Malabarba M, et al. Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet. 2009;5:e1000675 pubmed publisher
    ..Thus, we propose that TOCA proteins control tissues morphogenesis by coordinating Clathrin-dependent membrane trafficking with WAVE and N-WASP-dependent actin-dynamics. ..
  6. Itoh T, Erdmann K, Roux A, Habermann B, Werner H, De Camilli P. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. Dev Cell. 2005;9:791-804 pubmed
    ..These results suggest a close interplay between the mechanisms that control actin dynamics and those that mediate plasma membrane invagination and fission. ..
  7. Hong K, Kim S, Zhang X, Park S. Interactions among the variants of insulin-related genes and nutrients increase the risk of type 2 diabetes. Nutr Res. 2018;51:82-92 pubmed publisher
    ..The best model included six SNPs, FNBP1L-rs4847428, FNBP1L-rs23766, GLIS3-rs2027393, GLIS3-rs3892354, GLIS3-rs486163 and DLC1-rs17093957...
  8. Kleino I, Järviluoma A, Hepojoki J, Huovila A, Saksela K. Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions. PLoS ONE. 2015;10:e0121301 pubmed publisher
    ..Novel SH3 interactions revealed in this study include TOCA1 and CIP4 as preferred partners of ADAM8, and RIMBP1 as a partner of ADAM19...
  9. Lu Y, Ye Y, Bao W, Yang Q, Wang J, Liu Z, et al. Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing. Kidney Int. 2017;92:1119-1129 pubmed publisher
    ..HAUS8, RAB3B, LPIN2, GOLIM4, CERS6, ARHGEF18, ARPC1A, SRGAP1, ITGB5, ILDR2, MPP5, TSC22D1, DNAJC11, SEPT10, MOCS2, FNBP1L, and TMOD3) or significant downregulation of CD2AP and synaptopodin (IFT80, MYOM2, ANXA4, CYB5R4, GPC1, ZNF277, ..

More Information


  1. Park S, Choi Y, Jung N, Kim J, Oh S, Yu Y, et al. Autophagy induction in the skeletal myogenic differentiation of human tonsil-derived mesenchymal stem cells. Int J Mol Med. 2017;39:831-840 pubmed publisher
    ..In particular, we selected FNBP1L, which among the upregulated genes is essential for antibacterial autophagy, since autophagy is related to SKM ..
  2. Ouellette M, Martin E, Lacoste Caron G, Hamiche K, Jenna S. Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans. J Mol Cell Biol. 2016;8:313-27 pubmed publisher
    ..in an antagonistic manner with the CDC-42's effector WSP-1/N-WASP and the CDC-42-binding proteins TOCA-1/2/TOCA1. RGA-7 is recruited to spatially distinct locations at junctions between adjacent leading cells, where it promotes ..
  3. Watson J, Nietlispach D, Owen D, Mott H. (1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1. Biomol NMR Assign. 2016;10:407-11 pubmed publisher
    b>TOCA1 is a downstream effector protein of the small GTPase, Cdc42. It is a multi-domain protein that includes a membrane binding F-BAR domain, a homology region 1 (HR1) domain, which binds selectively to active Cdc42 and an SH3 domain...
  4. Chander H, Truesdell P, Meens J, Craig A. Transducer of Cdc42-dependent actin assembly promotes breast cancer invasion and metastasis. Oncogene. 2013;32:3080-90 pubmed publisher
    ..Taken together, our results identify Toca-1 as a proinvasive protein in breast adenocarcinoma and a potential therapeutic target to limit tumor metastasis. ..
  5. Watson J, Fox H, Nietlispach D, Gallop J, Owen D, Mott H. Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES. J Biol Chem. 2016;291:13875-90 pubmed publisher
    Transducer of Cdc42-dependent actin assembly protein 1 (TOCA1) is an effector of the Rho family small G protein Cdc42...
  6. Benyamin B, Pourcain B, Davis O, Davies G, Hansell N, Brion M, et al. Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry. 2014;19:253-8 pubmed publisher
    ..9 × 10(-15), 0.014 and 0.028). FNBP1L, previously reported to be the most significantly associated gene for adult intelligence, was also significantly ..
  7. Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, et al. miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics. Nat Cell Biol. 2012;14:697-706 pubmed publisher
    ..Gene expression analysis further identified ARP2, TOCA1, ABLIM1 and ABLIM3 as its targets in ciliation-related actin dynamics...
  8. Katoh M, Katoh M. Identification and characterization of human FNBP1L gene in silico. Int J Mol Med. 2004;13:157-62 pubmed
    ..Here, we identified and characterized the FNBP1-like (FNBP1L) gene by using bioinformatics. Human FLJ20275 (NM_017737.1) and mouse 2610318I01Rik (NM_153118...
  9. Bu W, Lim K, Yu Y, Chou A, Sudhaharan T, Ahmed S. Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. PLoS ONE. 2010;5:e12153 pubmed publisher
    ..Thus Cdc42 may influence endocytic membrane trafficking by regulating the formation and activity of the Toca-1/N-WASP complex. ..
  10. Aspenstrom P, Richnau N, Johansson A. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 2006;312:2180-94 pubmed
    ..Taken together, our data indicate that DAAM1 communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system. ..
  11. Kakimoto T, Katoh H, Negishi M. Regulation of neuronal morphology by Toca-1, an F-BAR/EFC protein that induces plasma membrane invagination. J Biol Chem. 2006;281:29042-53 pubmed
    ..These results suggest that a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP. ..
  12. Kovacs E, Makar R, Gertler F. Tuba stimulates intracellular N-WASP-dependent actin assembly. J Cell Sci. 2006;119:2715-26 pubmed
    ..These results suggest first that Tuba-stimulated dorsal ruffling might represent a novel mechanism for the coordination of N-WASP-dependent cytoskeletal rearrangements and second that Tuba function is implicated in motility processes. ..
  13. Chander H, Brien C, Truesdell P, Watt K, Meens J, Schick C, et al. Toca-1 is suppressed by p53 to limit breast cancer cell invasion and tumor metastasis. Breast Cancer Res. 2014;16:3413 pubmed publisher
    ..ChIP assays revealed p53 binding within intron 2 of toca1, and reduced histone acetylation within its promoter region upon p53 upregulation or activation...
  14. Huett A, Ng A, Cao Z, Kuballa P, Komatsu M, Daly M, et al. A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy. J Immunol. 2009;182:4917-30 pubmed publisher
    ..We selected one of these membrane interactors, FNBP1L (formin binding protein 1-like), an F-BAR-containing protein (also termed Toca-1), for further study based upon a ..
  15. Leung Y, Ally S, Goldberg M. Bacterial actin assembly requires toca-1 to relieve N-wasp autoinhibition. Cell Host Microbe. 2008;3:39-47 pubmed publisher
    ..flexneri type III secretion effectors. Thus, S. flexneri independently hijacks two nodes of the N-WASP actin assembly pathway to initiate localized actin tail assembly. ..