FNBP1

Summary

Gene Symbol: FNBP1
Description: formin binding protein 1
Alias: FBP17, formin-binding protein 1, formin-binding protein 17
Species: human
Products:     FNBP1

Top Publications

  1. Itoh T, Erdmann K, Roux A, Habermann B, Werner H, De Camilli P. Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins. Dev Cell. 2005;9:791-804 pubmed
    ..These results suggest a close interplay between the mechanisms that control actin dynamics and those that mediate plasma membrane invagination and fission. ..
  2. Takano K, Takano K, Toyooka K, Suetsugu S. EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization. EMBO J. 2008;27:2817-28 pubmed publisher
    ..Formin-binding protein 17 (FBP17) and Toca-1 contain EFC/F-BAR domains and bind to neural Wiskott-Aldrich syndrome protein (N-WASP), which links ..
  3. Kamioka Y, Fukuhara S, Sawa H, Nagashima K, Masuda M, Matsuda M, et al. A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem. 2004;279:40091-9 pubmed
    ..Here, we have investigated a new dynamin-associating molecule, formin-binding protein 17 (FBP17), involved in deforming the plasma membrane and in endocytosis...
  4. Shimada A, Niwa H, Tsujita K, Suetsugu S, Nitta K, Hanawa Suetsugu K, et al. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell. 2007;129:761-72 pubmed
    ..In the present study, we solved the crystal structures of the EFC domains of human FBP17 and CIP4...
  5. Kakimoto T, Katoh H, Negishi M. Identification of splicing variants of Rapostlin, a novel RND2 effector that interacts with neural Wiskott-Aldrich syndrome protein and induces neurite branching. J Biol Chem. 2004;279:14104-10 pubmed
    ..Therefore, we found that functionally different splicing variants of Rapostlin have different responses to Rnd2 in association with N-WASP. ..
  6. Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, Takenawa T. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol. 2006;172:269-79 pubmed
    ..domain is found in the pombe Cdc15 homology (PCH) protein family members, including formin-binding protein 17 (FBP17). However, the amino acid sequence homology extends beyond the FCH domain...
  7. Peterson J, Pitel B, Smoley S, Smadbeck J, Johnson S, Vasmatzis G, et al. Use of mate-pair sequencing to characterize a complex cryptic BCR/ABL1 rearrangement observed in a newly diagnosed case of chronic myeloid leukemia. Hum Pathol. 2018;: pubmed publisher
    ..myeloid leukemia with 2 cryptic insertional events resulting in BCR/ABL1 fusion on the derivative chromosome 9 and FNBP1/BCR fusion on the derivative chromosome 22...
  8. Chan Wah Hak L, Khan S, Di Meglio I, Law A, Lucken Ardjomande Häsler S, Quintaneiro L, et al. FBP17 and CIP4 recruit SHIP2 and lamellipodin to prime the plasma membrane for fast endophilin-mediated endocytosis. Nat Cell Biol. 2018;20:1023-1031 pubmed publisher
    ..Among them, FBP17 and CIP4 prime the membrane of resting cells for FEME by recruiting the 5'-lipid phosphatase SHIP2 and ..
  9. Suman P, Mishra S, Chander H. High expression of FBP17 in invasive breast cancer cells promotes invadopodia formation. Med Oncol. 2018;35:71 pubmed publisher
    ..In the present study, we address the role of another member (FBP17) of same family in the invasion breast cancer cells...

More Information

Publications30

  1. ZEGERS M, Friedl P. Translating Membrane Tension into Cytoskeletal Action by FBP17. Dev Cell. 2015;33:628-30 pubmed publisher
    ..They identify FBP17 as a multifunctional adaptor that senses membrane curvature and delivers feedback to actin dynamics and directed ..
  2. Xiao S, Tong C, Yang Y, Wu M. Mitotic Cortical Waves Predict Future Division Sites by Encoding Positional and Size Information. Dev Cell. 2017;43:493-506.e3 pubmed publisher
    ..Here, we show that concentric target or spiral waves of active Cdc42 and the F-BAR protein FBP17 are invoked in adherent cells at the onset of mitosis...
  3. Tsujita K, Kondo A, Kurisu S, Hasegawa J, Itoh T, Takenawa T. Antagonistic regulation of F-BAR protein assemblies controls actin polymerization during podosome formation. J Cell Sci. 2013;126:2267-78 pubmed publisher
    b>FBP17, an F-BAR domain protein, has emerged as a crucial factor linking the plasma membrane to WASP-mediated actin polymerization...
  4. Tsujita K, Takenawa T, Itoh T. Feedback regulation between plasma membrane tension and membrane-bending proteins organizes cell polarity during leading edge formation. Nat Cell Biol. 2015;17:749-58 pubmed publisher
    ..However, how membrane tension regulates actin assembly is unknown. Here, we demonstrate that FBP17, a membrane-bending protein and an activator of WASP/N-WASP-dependent actin nucleation, is a PM tension sensor ..
  5. Fuchs U, Rehkamp G, Slany R, Follo M, Borkhardt A. The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. FEBS Lett. 2003;554:10-6 pubmed
    ..We previously identified the formin-binding protein 17 (FBP17) as such an MLL fusion partner...
  6. Morin F, Vannier B, Houdart F, Regnacq M, Berges T, Voisin P. A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins. Mol Vis. 2003;9:449-59 pubmed
    ..A clone was isolated twice, that consisted essentially of the SH3 domain of the formin-binding protein 17 (FBP17). This interaction was confirmed by GST pull-down...
  7. Katoh M, Katoh M. FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 domains. Int J Mol Med. 2003;11:791-7 pubmed
    ..The region corresponding to codon 227-345 of FNBP2 was conserved among FNBP2 family proteins as well as FNBP1 and TRIP10 proteins...
  8. Serebriiskii I, Mitina O, Pugacheva E, Benevolenskaya E, Kotova E, Toby G, et al. Detection of peptides, proteins, and drugs that selectively interact with protein targets. Genome Res. 2002;12:1785-91 pubmed
  9. Aspenstrom P, Richnau N, Johansson A. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. Exp Cell Res. 2006;312:2180-94 pubmed
    ..Taken together, our data indicate that DAAM1 communicates with Rho GTPases, CIP4 and Src in the regulation of the signalling pathways that co-ordinate the dynamics of the actin filament system. ..
  10. Wu M, Huang B, Graham M, Raimondi A, Heuser J, Zhuang X, et al. Coupling between clathrin-dependent endocytic budding and F-BAR-dependent tubulation in a cell-free system. Nat Cell Biol. 2010;12:902-8 pubmed publisher
    ..including subdiffraction-limit imaging by stochastic optical reconstruction microscopy (STORM), revealed F-BAR (FBP17) domain coated tubules nucleated by clathrin-coated buds when fission was blocked by GTPgammaS...
  11. Ghadimi M, Sanzenbacher R, Thiede B, Wenzel J, Jing Q, Plomann M, et al. Identification of interaction partners of the cytosolic polyproline region of CD95 ligand (CD178). FEBS Lett. 2002;519:50-8 pubmed
    ..The determined peptide mass fingerprints correspond to Grb2, actin, beta-tubulin, formin binding protein 17 (FBP17) and PACSIN2...
  12. Tsuboi S, Takada H, Hara T, Mochizuki N, Funyu T, Saitoh H, et al. FBP17 Mediates a Common Molecular Step in the Formation of Podosomes and Phagocytic Cups in Macrophages. J Biol Chem. 2009;284:8548-56 pubmed publisher
    ..Here we have demonstrated that formin-binding protein 17 (FBP17) recruits WASP, WASP-interacting protein (WIP), and dynamin-2 to the plasma membrane and that this recruitment is ..
  13. Richnau N, Aspenstrom P. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1. J Biol Chem. 2001;276:35060-70 pubmed
  14. Qian J, Chen W, Lettau M, Podda G, Zörnig M, Kabelitz D, et al. Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL. Cell Signal. 2006;18:1327-37 pubmed
    ..Members of this protein family are characterized by a similar domain structure and include FBP17, PACSIN1-3, CD2BP1, CIP4, Rho-GAP C1 and several hypothetical proteins...
  15. Zhou F, Zhang W, Chen G, Zhao W, Cao X, Chen Y, et al. Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma. Cancer Immunol Immunother. 2006;55:910-7 pubmed
    ..In summary, the antigens identified in this study may be potential candidates for diagnosis and targets for immunotherapy in MM. ..
  16. Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M. Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. J Biol Chem. 2002;277:45428-34 pubmed
    ..Therefore, Rapostlin is the first effector of Rnd2, regulating neurite branch formation. ..
  17. Fuchs U, Rehkamp G, Haas O, Slany R, Konig M, Bojesen S, et al. The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. Proc Natl Acad Sci U S A. 2001;98:8756-61 pubmed
    ..partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL...
  18. Wakita Y, Kakimoto T, Katoh H, Negishi M. The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons. J Biol Chem. 2011;286:32672-83 pubmed publisher
    ..Among them, Rapostlin/formin-binding protein 17 (FBP17) has attracted increasing attention as a critical coordinator of endocytosis...
  19. Xiong D, Xiao S, Guo S, Lin Q, Nakatsu F, Wu M. Frequency and amplitude control of cortical oscillations by phosphoinositide waves. Nat Chem Biol. 2016;12:159-66 pubmed publisher
  20. Larocca M, Shanks R, Tian L, Nelson D, Stewart D, Goldenring J. AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus. Mol Biol Cell. 2004;15:2771-81 pubmed publisher
    ..and pull-down assays, we found that AKAP350 interacts with a family of structurally related proteins, including FBP17, FBP17b, and cdc42 interacting protein 4 (CIP4)...
  21. Yang Y, Xiong D, Pipathsouk A, Weiner O, Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Dev Cell. 2017;43:507-521.e4 pubmed publisher
    ..onset of clathrin waves, but not individual endocytic events, requires feedback from downstream factors, including FBP17, Cdc42, and N-WASP...