flotillin-1

Summary

Gene Symbol: flotillin-1
Description: flotillin 1
Alias: flotillin-1, integral membrane component of caveolae
Species: human
Products:     flotillin-1

Top Publications

  1. Bickel P, Scherer P, Schnitzer J, Oh P, Lisanti M, Lodish H. Flotillin and epidermal surface antigen define a new family of caveolae-associated integral membrane proteins. J Biol Chem. 1997;272:13793-802 pubmed
    ..Significantly, flotillin is a marker for the Triton-insoluble, buoyant membrane fraction in brain, where to date mRNA species for known caveolin gene family members have not been detected. ..
  2. Riento K, Frick M, Schafer I, Nichols B. Endocytosis of flotillin-1 and flotillin-2 is regulated by Fyn kinase. J Cell Sci. 2009;122:912-8 pubmed publisher
    ..Uptake of the GPI-linked protein CD59 is reduced by expression of the phenylalanine-mutated flotillins. These data establish uptake of flotillin microdomains as a tyrosine-kinase-regulated endocytic process. ..
  3. Frick M, Bright N, Riento K, Bray A, Merrified C, Nichols B. Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Curr Biol. 2007;17:1151-6 pubmed
    ..Key attributes of this machinery are the dependence on coassembly of both flotillins and the inference that flotillin microdomains can exist in either flat or invaginated states. ..
  4. Ge L, Qi W, Wang L, Miao H, Qu Y, Li B, et al. Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. Proc Natl Acad Sci U S A. 2011;108:551-6 pubmed publisher
  5. Lin C, Wu Z, Lin X, Yu C, Shi T, Zeng Y, et al. Knockdown of FLOT1 impairs cell proliferation and tumorigenicity in breast cancer through upregulation of FOXO3a. Clin Cancer Res. 2011;17:3089-99 pubmed publisher
    ..FLOT1 plays an important role in promoting proliferation and tumorigenesis of human breast cancer and may represent a novel prognostic biomarker and therapeutic target for the disease. ..
  6. Baumann C, Ribon V, Kanzaki M, Thurmond D, Mora S, Shigematsu S, et al. CAP defines a second signalling pathway required for insulin-stimulated glucose transport. Nature. 2000;407:202-7 pubmed
    ..Thus, localization of the Cbl-CAP complex to lipid rafts generates a pathway that is crucial in the regulation of glucose uptake. ..
  7. Babuke T, Ruonala M, Meister M, Amaddii M, Genzler C, Esposito A, et al. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell Signal. 2009;21:1287-97 pubmed publisher
    ..Based on our findings, we propose a model according to which reggie hetero-oligomers are dynamic, and changes in the size of the hetero-oligomers result in endocytosis of the complex from the plasma membrane. ..
  8. Glebov O, Bright N, Nichols B. Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat Cell Biol. 2006;8:46-54 pubmed
    ..We propose that flotillin-1 is one determinant of a clathrin-independent endocytic pathway in mammalian cells. ..
  9. Jacobowitz D, Kallarakal A. Flotillin-1 in the substantia nigra of the Parkinson brain and a predominant localization in catecholaminergic nerves in the rat brain. Neurotox Res. 2004;6:245-57 pubmed
    ..Development 124:577-87, 1997) which suggests that flotillin-1/reggie-2 might play a role in axonal growth from the remaining substantia nigra cells of the Parkinson brain. ..

More Information

Publications86

  1. Tomasovic A, Traub S, Tikkanen R. Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS ONE. 2012;7:e29739 pubmed publisher
  2. Pust S, Klokk T, Musa N, Jenstad M, Risberg B, Erikstein B, et al. Flotillins as regulators of ErbB2 levels in breast cancer. Oncogene. 2013;32:3443-51 pubmed publisher
    ..As a consequence, ErbB2-triggered downstream signalling is inhibited. Our data demonstrate a novel mechanism for interfering with ErbB2 signalling, which potentially can have clinical impact. ..
  3. Xiong P, Xiao L, Yang R, Guo Q, Zhao Y, Li W, et al. Flotillin-1 promotes cell growth and metastasis in oral squamous cell carcinoma. Neoplasma. 2013;60:395-405 pubmed publisher
    ..Our studies suggested that Flotillin-1 plays an important role in OSCC development, and might be a potential therapeutic target for OSCC. ..
  4. Stuermer C, Lang D, Kirsch F, Wiechers M, Deininger S, Plattner H. Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. Mol Biol Cell. 2001;12:3031-45 pubmed
    ..Thus, reggie-1 and -2 define raft-related microdomain signaling centers in neurons and T cells, and the protein complex involved in signaling becomes subject to degradation. ..
  5. Santamaria A, Castellanos E, Gómez V, Benedit P, Renau Piqueras J, Morote J, et al. PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol. 2005;25:1900-11 pubmed
    ..These observations suggest that PTOV1 assists flotillin-1 in its translocation to the nucleus and that both proteins are required for cell proliferation. ..
  6. Edgar A, Polak J. Flotillin-1: gene structure: cDNA cloning from human lung and the identification of alternative polyadenylation signals. Int J Biochem Cell Biol. 2001;33:53-64 pubmed
    ..The long central alpha-helical domain may form a coiled-coil. We have isolated and characterised a cDNA encoding the human flotillin-1 gene, which may play an important role in raft formation. ..
  7. Rajendran L, Beckmann J, Magenau A, Boneberg E, Gaus K, Viola A, et al. Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLoS ONE. 2009;4:e8290 pubmed publisher
    ..Based on our results, we propose that in hematopoietic cells, flotillins provide intrinsic cues that govern segregation of certain microdomain-associated molecules during immune cell polarization...
  8. Sugawara Y, Nishii H, Takahashi T, Yamauchi J, Mizuno N, Tago K, et al. The lipid raft proteins flotillins/reggies interact with Galphaq and are involved in Gq-mediated p38 mitogen-activated protein kinase activation through tyrosine kinase. Cell Signal. 2007;19:1301-8 pubmed
    ..These lines of evidence suggested that a Gq-coupled receptor activates specifically p38 MAPK through lipid rafts and Src kinase activation, in which flotillins positively modulate the Gq signaling. ..
  9. Limpert A, Karlo J, Landreth G. Nerve growth factor stimulates the concentration of TrkA within lipid rafts and extracellular signal-regulated kinase activation through c-Cbl-associated protein. Mol Cell Biol. 2007;27:5686-98 pubmed
    ..These data provide a mechanism for the lipid raft localization of TrkA and establish the importance of the CAP adaptor protein for NGF activation of the ERKs and neuronal differentiation. ..
  10. Rossy J, Schlicht D, Engelhardt B, Niggli V. Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS ONE. 2009;4:e5403 pubmed publisher
    ..These results suggest that flotillin-rich actin-dependent membrane microdomains are importantly involved in neutrophil uropod formation and/or stabilization and organize uropod localization of PSGL-1. ..
  11. Salzer U, Prohaska R. Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. Blood. 2001;97:1141-3 pubmed
    ..Stomatin and the flotillins are present as independently organized high-order oligomers, suggesting that these complexes act as separate scaffolding components at the cytoplasmic face of erythrocyte lipid rafts...
  12. Amaddii M, Meister M, Banning A, Tomasovic A, Mooz J, Rajalingam K, et al. Flotillin-1/reggie-2 protein plays dual role in activation of receptor-tyrosine kinase/mitogen-activated protein kinase signaling. J Biol Chem. 2012;287:7265-78 pubmed publisher
    ..Furthermore, our results imply that other receptor-tyrosine kinases may also rely on flotillin-1 upon activation, thus suggesting a general role for flotillin-1 as a novel factor in receptor-tyrosine kinase/MAP kinase signaling. ..
  13. Li H, Wang R, Liu S, Zhang J, Luo J, Zhang B, et al. Abnormal expression of FLOT1 correlates with tumor progression and poor survival in patients with non-small cell lung cancer. Tumour Biol. 2014;35:3311-5 pubmed publisher
    ..Taken together, our findings indicate that FLOT1 may play an important role in NSCLC tumorigenesis. Further elucidation of the molecular mechanisms underlying the role of FLOT1 is warranted. ..
  14. Kimura A, Baumann C, Chiang S, Saltiel A. The sorbin homology domain: a motif for the targeting of proteins to lipid rafts. Proc Natl Acad Sci U S A. 2001;98:9098-103 pubmed
    ..These results suggest a mechanism for localization of signaling proteins to the lipid raft that mediates the compartmentalization of crucial signal transduction pathways. ..
  15. Kurrle N, Ockenga W, Meister M, Völlner F, Kühne S, John B, et al. Phosphatidylinositol 3-Kinase dependent upregulation of the epidermal growth factor receptor upon Flotillin-1 depletion in breast cancer cells. BMC Cancer. 2013;13:575 pubmed publisher
  16. Cremona M, Matthies H, Pau K, Bowton E, SPEED N, Lute B, et al. Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci. 2011;14:469-77 pubmed publisher
    ..In sum, our findings provide evidence for a critical role of Flot1-enriched membrane microdomains in PKC-triggered DAT endocytosis and the actions of amphetamine. ..
  17. Volonte D, Galbiati F, Li S, Nishiyama K, Okamoto T, Lisanti M. Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. J Biol Chem. 1999;274:12702-9 pubmed
    ..As a consequence of these findings, we propose the term "cavatellins" be used (instead of flotillins) to describe this gene family. ..
  18. Vassilieva E, Ivanov A, Nusrat A. Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells. Biochem Biophys Res Commun. 2009;379:460-5 pubmed publisher
    ..Our data suggest that flotillin-1 regulates caveolin-1 level by preventing its lysosomal degradation in intestinal epithelial cells. ..
  19. Gauss A, Buchholz I, Zahn A, Schmitz G, Stremmel W, Fuellekrug J, et al. Flotillin-2 expression in the human gut: from a cell model to human tissue in health and inflammatory bowel diseases. Int J Med Sci. 2013;10:1259-70 pubmed publisher
    ..By virtue of its abundant expression in enterocytes, flotillin-2 must have an essential function in intestinal physiology, especially in the colon. Yet our data could not link flotillin-2 to the pathogenesis of IBD. ..
  20. Asp N, Pust S, Sandvig K. Flotillin depletion affects ErbB protein levels in different human breast cancer cells. Biochim Biophys Acta. 2014;1843:1987-96 pubmed publisher
    ..Thus, flotillins are crucial regulators for oncogenic ErbB function and potential targets for cancer treatment. ..
  21. Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Kruger M, et al. The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Mol Biol Cell. 2011;22:202-15 pubmed publisher
    ..In sum, we identify the kinesin KIF9 and reggie/flotillin proteins as novel regulators of macrophage podosomes and show that their interaction is critical for the matrix-degrading ability of these structures. ..
  22. Yang P, Lu Z, Pan Q, Chen T, Feng X, Wang S, et al. MicroRNA-6809-5p mediates luteolin-induced anticancer effects against hepatoma by targeting flotillin 1. Phytomedicine. 2018;57:18-29 pubmed publisher
    ..reporter assay were utilized to confirm the binding of miR-6809-5p to the 3'-untranslated region (3'-UTR) of flotillin 1 (FLOT1)...
  23. Xu X, Wu J, Li S, Hu Z, Xu X, Zhu Y, et al. Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway. Mol Cancer. 2014;13:109 pubmed publisher
    ..These findings highlight an important role for miR-182-5p in the pathogenesis of RCC, and restoration of miR-182-5p could be considered as a potential therapeutic strategy for RCC therapy. ..
  24. Säälik P, Padari K, Niinep A, Lorents A, Hansen M, Jokitalo E, et al. Protein delivery with transportans is mediated by caveolae rather than flotillin-dependent pathways. Bioconjug Chem. 2009;20:877-87 pubmed publisher
    ..The participation of the caveolin-1-dependent pathway in CPP-mediated protein delivery was also corroborated by using caveolin-1 knockout mouse embryonic fibroblasts. ..
  25. Yu M, Liu H, Dong Z, Xiao J, Su B, Fan L, et al. The dynamics and endocytosis of Flot1 protein in response to flg22 in Arabidopsis. J Plant Physiol. 2017;215:73-84 pubmed publisher
    ..Taken together, these findings support the hypothesis that the changing of dynamics and oligomeric states can promote the endocytosis and degradation of Flot1 under flg22 treatment in plant cells. ..
  26. Hazarika P, Dham N, Patel P, Cho M, Weidner D, Goldsmith L, et al. Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. J Cell Biochem. 1999;75:147-59 pubmed
    ..Homology between the cDNA sequence has been reported with flotillin 1, a caveolae associated protein, as well as Reggie 1 and 2, neuronal proteins expressed during axonal ..
  27. Affentranger S, Martinelli S, Hahn J, Rossy J, Niggli V. Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes. BMC Cell Biol. 2011;12:28 pubmed publisher
    ..Our data also implicate flotillin-rich actin-dependent membrane microdomains in T-lymphocyte uropod formation. ..
  28. Ding Y, Jiang M, Jiang W, Su Y, Zhou H, Hu X, et al. Expression, purification, and characterization of recombinant human flotillin-1 in Escherichia coli. Protein Expr Purif. 2005;42:137-45 pubmed
    ..This is the first report describing expression, purification, and characterization of active recombinant raft specific protein in large quantity and highly purity, which would facilitate further research such as X-ray crystallography. ..
  29. Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, et al. Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis. J Clin Invest. 2016;126:4537-4553 pubmed publisher
    ..Moreover, they shed light on the understanding of vesicle trafficking in other stem cells and on the development of improved strategies for cancer treatment. ..
  30. Carignano H, Roldan D, Beribe M, Raschia M, Amadio A, Nani J, et al. Genome-wide scan for commons SNPs affecting bovine leukemia virus infection level in dairy cattle. BMC Genomics. 2018;19:142 pubmed publisher
    ..Data obtained represent a step forward to understand the biology of BLV-bovine interaction, and provide genetic information potentially applicable to selective breeding programs. ..
  31. Fork C, Hitzel J, Nichols B, Tikkanen R, Brandes R. Flotillin-1 facilitates toll-like receptor 3 signaling in human endothelial cells. Basic Res Cardiol. 2014;109:439 pubmed publisher
    ..Collectively, these data suggest that interaction between flotillin-1 and caveolin-1 may facilitate the transport of TLR3-ligands to its intracellular receptor and enables inflammatory TLR3 signaling. ..
  32. Liang Z, Wang X, Xu X, Xie B, Ji A, Meng S, et al. MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway. Mol Cancer. 2017;16:96 pubmed publisher
    ..miR-608 is a potential tumor suppressor in BCa, and the restoration of miR-608 might be a promising therapeutic option for BCa. ..
  33. Yu P, Yang Z, Jones J, Wang Z, Owens S, Mueller S, et al. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int. 2004;66:2167-80 pubmed
    ..The majority of hD1Rs are distributed in lipid rafts. Heterologously and endogenously expressed D1Rs in renal cells are associated with and regulated by caveolin-2. ..
  34. Baumann T, Affentranger S, Niggli V. Evidence for chemokine-mediated coalescence of preformed flotillin hetero-oligomers in human T-cells. J Biol Chem. 2012;287:39664-72 pubmed publisher
    ..Our results support predominant formation of flotillin-1 and -2 hetero-oligomers in resting and chemokine-stimulated human T-cells which may importantly contribute to structuring of the uropod. ..
  35. Li L, Luo J, Wang B, Wang D, Xie X, Yuan L, et al. Microrna-124 targets flotillin-1 to regulate proliferation and migration in breast cancer. Mol Cancer. 2013;12:163 pubmed publisher
    ..Our study demonstrated that miR-124 might be a tumor suppressor in breast cancer via the regulation of FLOT1. This microRNA could serve as a potential diagnostic marker and therapeutic target for breast cancer. ..
  36. Oeffner F, Moch C, Neundorf A, Hofmann J, Koch M, Grzeschik K. Novel interaction partners of Bardet-Biedl syndrome proteins. Cell Motil Cytoskeleton. 2008;65:143-55 pubmed
    ..Our work provides new insights into the understanding of BBS interactions and thus their biological function. ..
  37. Park M, Kim N, Wu L, Yu G, Park K. Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells. Biochem Biophys Res Commun. 2016;476:237-244 pubmed publisher
    ..Our results suggest that flot-1 and -2 are partially involved in CME of M3R by facilitating its internalization. ..
  38. Korhonen J, Puolakkainen M, Häivälä R, Penttilä T, Haveri A, Markkula E, et al. Flotillin-1 (Reggie-2) contributes to Chlamydia pneumoniae growth and is associated with bacterial inclusion. Infect Immun. 2012;80:1072-8 pubmed publisher
    ..These results suggest that flotillin-1 localizes to the C. pneumoniae inclusion membrane and plays an important role for intracellular growth of C. pneumoniae. ..
  39. Koh M, Yong H, Kim E, Son H, Jeon Y, Hwang J, et al. A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness. Int J Cancer. 2016;138:1232-45 pubmed publisher
    ..001). Our findings provide insight into the molecular basis of Ras isoform-specific interplay with flotillin-1, leading to tumorigenicity and aggressiveness of breast cancer. ..
  40. Jerman S, Ward H, Lee R, Lopes C, Fry A, Macdougall M, et al. OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts. PLoS ONE. 2014;9:e106330 pubmed publisher
    ..Together, these data suggest that polycystins are necessary for assembly of a novel flotillin-containing ciliary signaling complex and provide a molecular rationale for the common renal pathologies caused by OFD1 and PKD mutations. ..
  41. Joe M, Sohn S, Choi Y, Park H, Kee C. Identification of flotillin-1 as a protein interacting with myocilin: implications for the pathogenesis of primary open-angle glaucoma. Biochem Biophys Res Commun. 2005;336:1201-6 pubmed
    ..Although the physiological significance of the interaction has yet to be elucidated, our results showed that the alteration of the interaction by mutations in MYOC might be a key factor of the pathogenesis of POAG. ..
  42. Butz H, Szabó P, Khella H, Nofech Mozes R, Patocs A, Yousef G. miRNA-target network reveals miR-124as a key miRNA contributing to clear cell renal cell carcinoma aggressive behaviour by targeting CAV1 and FLOT1. Oncotarget. 2015;6:12543-57 pubmed
    ..Restoration of the levels of these miRNAs could be considered as a potential therapeutic strategy for ccRCC. ..
  43. Ogura M, Yamaki J, Homma M, Homma Y. Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species. FEBS Lett. 2014;588:2837-43 pubmed publisher
    ..Our findings suggest a critical role of flotillin-1 in ROS production mediated by c-Src. ..
  44. Chen K, Wu Q, Hu K, Yang C, Wu X, Cheung P, et al. Suppression of Hepatic FLOT1 (Flotillin-1) by Type 2 Diabetes Mellitus Impairs the Disposal of Remnant Lipoproteins via Syndecan-1. Arterioscler Thromb Vasc Biol. 2018;38:102-113 pubmed publisher
    ..FLOT1 is a novel participant in the disposal of harmful C-TRLs via syndecan-1. Low expression of FLOT1 in T2DM liver may contribute to metabolic dyslipoproteinemia. ..
  45. Tomiyama A, Uekita T, Kamata R, Sasaki K, Takita J, Ohira M, et al. Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association. Cancer Res. 2014;74:3790-801 pubmed publisher
    ..Taken together, our findings suggest that attenuation of FLOT1-ALK binding drives malignant phenotypes of neuroblastoma by activating ALK signaling. ..
  46. Cao S, Cui Y, Xiao H, Mai M, Wang C, Xie S, et al. Upregulation of flotillin-1 promotes invasion and metastasis by activating TGF-β signaling in nasopharyngeal carcinoma. Oncotarget. 2016;7:4252-64 pubmed publisher
    ..Our findings present new evidence that FLOT1 plays an important role in promoting aggressive behavior of NPC and provide new insights into the regulatory mechanism of TGF-β signaling. ..
  47. Johansson E, Jonson I, Bosaeus M, Jennische E. Identification of flotillin-1 as an interacting protein for antisecretory factor. Regul Pept. 2008;146:303-9 pubmed publisher
    ..Intracellular AF may affect secretory processes by regulating the localization of signal proteins to lipid rafts. ..
  48. Bohl C, Abrahamyan L, Wood C. Human Ubc9 is involved in intracellular HIV-1 Env stability after trafficking out of the trans-Golgi network in a Gag dependent manner. PLoS ONE. 2013;8:e69359 pubmed publisher
    ..This study provides further insight in the processing and packaging of the HIV-1 gp120 into mature HIV-1 virions...
  49. Yang F, Zhang H, Zhang H, Chen S, Yan Y, Zheng J. MiR-506 is down-regulated in clear cell renal cell carcinoma and inhibits cell growth and metastasis via targeting FLOT1. PLoS ONE. 2015;10:e0120258 pubmed publisher
    ..Rescue of FLOT1 expression partially restored the effects of miR-506. miR-506 exerts its anti-cancer function by directly targeting FLOT1 in renal cancer, indicating a potential novel therapeutic role in renal cancer treatment. ..
  50. Hagedorn M, Soldati T. Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection. Cell Microbiol. 2007;9:2716-33 pubmed publisher
    ..marinum. Conversely, the absence of the small GTPase RacH renders the host more susceptible to M. marinum proliferation but inhibits its cell-to-cell spreading...
  51. Chen T, Liu P, Ruan C, Chiu L, Kung F. The intracellular domain of amyloid precursor protein interacts with flotillin-1, a lipid raft protein. Biochem Biophys Res Commun. 2006;342:266-72 pubmed
  52. Gómez V, Sesé M, Santamaria A, Martinez J, Castellanos E, Soler M, et al. Regulation of aurora B kinase by the lipid raft protein flotillin-1. J Biol Chem. 2010;285:20683-90 pubmed publisher
    ..These observations are the first evidence for a function of Flotillin-1 outside of lipid rafts and suggest its critical role in the maintenance of a pool of active Aurora B. ..
  53. Haglund K, Ivankovic Dikic I, Shimokawa N, Kruh G, Dikic I. Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. J Cell Sci. 2004;117:2557-68 pubmed
    ..Our results indicate that recruitment of Pyk2/Cbl complexes to lipid rafts participates in growth factor-induced regulation of the actin cytoskeleton in growing neurites. ..
  54. Walton J, Frey H, Vandre D, Kwiek J, Ishikawa T, Takizawa T, et al. Expression of flotillins in the human placenta: potential implications for placental transcytosis. Histochem Cell Biol. 2013;139:487-500 pubmed publisher
    ..These findings suggest that flotillin-dependent endocytosis is unlikely to be a major pathway in the ST, but may be important in the CT and endothelium. ..
  55. Girardot N, Allinquant B, Duyckaerts C. [Lipid rafts, flotillin-1 and Alzheimer disease]. J Soc Biol. 2003;197:223-9 pubmed
    ..Our data suggest that the A beta peptide, which is poorly soluble in water, is actually linked with cholesterol, possibly from cellular membranes, in the extracellular space. ..
  56. Nebl T, Pestonjamasp K, Leszyk J, Crowley J, Oh S, Luna E. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002;277:43399-409 pubmed
    ..Other DRM-H components include lipid raft-associated integral membrane proteins (stomatin, flotillin 1, and flotillin 2), extracellular surface-bound and glycophosphatidylinositol-anchored proteins (IgM, membrane-..
  57. Zhang S, Wang C, Shi L, Li X, Zhou J, Song L, et al. High Expression of FLOT1 Is Associated with Progression and Poor Prognosis in Hepatocellular Carcinoma. PLoS ONE. 2013;8:e64709 pubmed publisher
    ..Our study demonstrated FLOT1 is associated with aggressive characteristics of HCC, and suggested the possibility of its use as a prognostic marker in patients with HCC. ..
  58. Ren K, Gao C, Zhang J, Wang K, Xu Y, Wang S, et al. Flotillin-1 mediates PrPc endocytosis in the cultured cells during Cu²? stimulation through molecular interaction. Mol Neurobiol. 2013;48:631-46 pubmed publisher
  59. Hahn S, Trendelenburg G, Scharf M, Denno Y, Brakopp S, Teegen B, et al. Identification of the flotillin-1/2 heterocomplex as a target of autoantibodies in bona fide multiple sclerosis. J Neuroinflammation. 2017;14:123 pubmed publisher
    ..Autoantibodies against the flotillin-1/2 heterocomplex, a peripheral membrane protein that is involved in axon outgrowth and regeneration of the optic nerve, are present in 1-2% of patients with bona fide MS. ..
  60. Haritunians T, Taylor K, Targan S, Dubinsky M, Ippoliti A, Kwon S, et al. Genetic predictors of medically refractory ulcerative colitis. Inflamm Bowel Dis. 2010;16:1830-40 pubmed publisher
    ..Furthermore, discovery of genetic processes underlying disease severity may help to identify pathways for novel therapeutic intervention in severe UC. ..
  61. Ruiz A, Hill M, Schmitt K, Stephens E. Membrane raft association of the Vpu protein of human immunodeficiency virus type 1 correlates with enhanced virus release. Virology. 2010;408:89-102 pubmed publisher
    ..Finally, we present data showing that raft association-defective transmembrane mutants of Vpu have impaired enhanced virus release function, but still maintain the ability to down-regulate CD4. ..
  62. Ren K, Wang K, Xu Y, Li L, Zhang J, Wang H, et al. [Study on the correlation between membrane protein Flotillin-1 and PrPc endocytosis]. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2012;26:435-8 pubmed
    ..The membrane-associated protein Flotillin-1 has the relationship with the endocytosis of PrPc. ..
  63. Arkhipova K, Sheyderman A, Laktionov K, Mochalnikova V, Zborovskaya I. Simultaneous expression of flotillin-1, flotillin-2, stomatin and caveolin-1 in non-small cell lung cancer and soft tissue sarcomas. BMC Cancer. 2014;14:100 pubmed publisher
    ..We also suggest the existence of some relationship between the expression of these proteins. ..
  64. Hwangbo C, Tae N, Lee S, Kim O, Park O, Kim J, et al. Syntenin regulates TGF-β1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-β type I receptor internalization. Oncogene. 2016;35:389-401 pubmed publisher
  65. Wakasugi K, Nakano T, Kitatsuji C, Morishima I. Human neuroglobin interacts with flotillin-1, a lipid raft microdomain-associated protein. Biochem Biophys Res Commun. 2004;318:453-60 pubmed
    ..Since Galpha exists within lipid rafts critical for signal transduction and flotillin-1 recruits signaling proteins to lipid rafts, flotillin-1 might recruit Ngb to lipid rafts as a means of preventing neuronal death. ..
  66. Meister M, Zuk A, Tikkanen R. Role of dynamin and clathrin in the cellular trafficking of flotillins. FEBS J. 2014;281:2956-76 pubmed publisher
    ..These data show that clathrin and dynamin are required for the endosomal sorting of flotillins, and the study provides a mechanistic dissection of the thus far poorly characterized endosomal trafficking of flotillins. ..
  67. Rhee H, Ji L, Kim S, Lee J. Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin?dependent pathway. Int J Mol Med. 2013;32:1126-36 pubmed publisher
  68. Yang Q, Zhu M, Wang Z, Li H, Zhou W, Xiao X, et al. 4.1N is involved in a flotillin-1/?-catenin/Wnt pathway and suppresses cell proliferation and migration in non-small cell lung cancer cell lines. Tumour Biol. 2016;37:12713-12723 pubmed
    ..1N is involved in the suppression of cell proliferation and migration through a flotillin-1/?-catenin/Wnt pathway. Taken together, the findings of this study help to elucidate the novel tumor suppressor role of 4.1N in NSCLC. ..
  69. Kim J, Yoon J, Kim Y. HIV-1 Tat interacts with and regulates the localization and processing of amyloid precursor protein. PLoS ONE. 2013;8:e77972 pubmed publisher
    ..These results suggest that HIV-1 Tat may contribute to HAND by interacting with and modifying APP processing, thereby increasing A? production. ..
  70. Hashimoto N, Hamamura K, Kotani N, Furukawa K, Kaneko K, Honke K, et al. Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering. Proteomics. 2012;12:3154-63 pubmed publisher
    ..Representative examples of GD3-associated molecules such as neogenin and MCAM were shown...
  71. Kasper J, Hermanns M, Bantz C, Koshkina O, Lang T, Maskos M, et al. Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins. Arch Toxicol. 2013;87:1053-65 pubmed publisher
    ..Additionally, the viability of aSNP-exposed cells was reduced in these cells. These findings indicate a contribution of flotillins in as yet unknown (clathrin or caveolae-independent) endocytosis mechanisms and (or) endosomal storage. ..
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    ..We have identified flotillin 1 and 2 as new partners of the cadherin complexes...
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    ..FLOT1 expression is associated with cN0 TSCC progression and may be valuable for the prognostic evaluation of cN0 TSCC. ..
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    ..It is concluded that ABCA1 forms a complex with syntaxin 13 and flotillin-1, residing at the plasma membrane and in phagosomes that are partially located in raft microdomains. ..
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    ..These findings indicate S100A11, combined with LASP1, plays a critical role in promoting CRC metastasis via its subcellular effectors, FLOT1 and histone H1. ..
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    ..Given that many viruses utilize cellular lipid microdomains for viral entry and assembly, it is plausible that lipid-enriched domains provide microenvironments where TRIM5? recognizes retroviral components. ..