Gene Symbol: FLOT2
Description: flotillin 2
Alias: ECS-1, ECS1, ESA, ESA1, M17S1, flotillin-2, Flotillin 2 (epidermal surface antigen 1), epidermal surface antigen, membrane component chromosome 17 surface marker 1, membrane component, chromosome 17, surface marker 1 (35kD protein identified by monoclonal antibody ECS-1)
Species: human
Products:     FLOT2

Top Publications

  1. Stuermer C, Lang D, Kirsch F, Wiechers M, Deininger S, Plattner H. Glycosylphosphatidyl inositol-anchored proteins and fyn kinase assemble in noncaveolar plasma membrane microdomains defined by reggie-1 and -2. Mol Biol Cell. 2001;12:3031-45 pubmed
    ..Thus, reggie-1 and -2 define raft-related microdomain signaling centers in neurons and T cells, and the protein complex involved in signaling becomes subject to degradation. ..
  2. Hazarika P, McCarty M, Prieto V, George S, Babu D, Koul D, et al. Up-regulation of Flotillin-2 is associated with melanoma progression and modulates expression of the thrombin receptor protease activated receptor 1. Cancer Res. 2004;64:7361-9 pubmed
    b>Flotillin 2 (flot-2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways...
  3. Solis G, Schrock Y, Hülsbusch N, Wiechers M, Plattner H, Stuermer C. Reggies/flotillins regulate E-cadherin-mediated cell contact formation by affecting EGFR trafficking. Mol Biol Cell. 2012;23:1812-25 pubmed publisher
    ..Thus, by promoting EGFR internalization, reggies restrict the EGFR signaling involved in E-cadherin macropinocytosis and recycling and regulate AJ formation and dynamics and thereby cell adhesion. ..
  4. Pust S, Klokk T, Musa N, Jenstad M, Risberg B, Erikstein B, et al. Flotillins as regulators of ErbB2 levels in breast cancer. Oncogene. 2013;32:3443-51 pubmed publisher
    ..As a consequence, ErbB2-triggered downstream signalling is inhibited. Our data demonstrate a novel mechanism for interfering with ErbB2 signalling, which potentially can have clinical impact. ..
  5. Schroeder W, Stewart Galetka S, Mandavilli S, Parry D, Goldsmith L, Duvic M. Cloning and characterization of a novel epidermal cell surface antigen (ESA). J Biol Chem. 1994;269:19983-91 pubmed
    ..here the isolation and characterization of a cDNA that encodes a novel extracellular epidermal molecule, epidermal surface antigen (ESA), which is thought to play a role in intercellular epidermal adhesion...
  6. Volonte D, Galbiati F, Li S, Nishiyama K, Okamoto T, Lisanti M. Flotillins/cavatellins are differentially expressed in cells and tissues and form a hetero-oligomeric complex with caveolins in vivo. Characterization and epitope-mapping of a novel flotillin-1 monoclonal antibody probe. J Biol Chem. 1999;274:12702-9 pubmed
    ..As a consequence of these findings, we propose the term "cavatellins" be used (instead of flotillins) to describe this gene family. ..
  7. Hazarika P, Dham N, Patel P, Cho M, Weidner D, Goldsmith L, et al. Flotillin 2 is distinct from epidermal surface antigen (ESA) and is associated with filopodia formation. J Cell Biochem. 1999;75:147-59 pubmed
    ..keratinocytes, stains the intercellular glycocalyx with a pemphigus-like pattern and recognizes a 35-kDa epidermal surface antigen (ESA) on Western blotting of keratinocyte extracts...
  8. Doherty S, Prieto V, George S, Hazarika P, Duvic M. High flotillin-2 expression is associated with lymph node metastasis and Breslow depth in melanoma. Melanoma Res. 2006;16:461-3 pubmed
  9. Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, et al. Identification of flotillin-2, a major protein on lipid rafts, as a novel target of p53 family members. Mol Cancer Res. 2008;6:395-406 pubmed publisher
    ..Thus, in addition to direct transactivation, p53 family member genes enhance a set of cellular processes via lipid rafts. ..

More Information

Publications103 found, 100 shown here

  1. Rossy J, Schlicht D, Engelhardt B, Niggli V. Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod. PLoS ONE. 2009;4:e5403 pubmed publisher
    ..These results suggest that flotillin-rich actin-dependent membrane microdomains are importantly involved in neutrophil uropod formation and/or stabilization and organize uropod localization of PSGL-1. ..
  2. Solis G, Malaga Trillo E, Plattner H, Stuermer C. Cellular roles of the prion protein in association with reggie/flotillin microdomains. Front Biosci (Landmark Ed). 2010;15:1075-85 pubmed
  3. Zhu Z, Wang J, Sun Z, Sun X, Wang Z, Xu H. Flotillin2 expression correlates with HER2 levels and poor prognosis in gastric cancer. PLoS ONE. 2013;8:e62365 pubmed publisher
  4. Salzer U, Prohaska R. Stomatin, flotillin-1, and flotillin-2 are major integral proteins of erythrocyte lipid rafts. Blood. 2001;97:1141-3 pubmed
    ..Stomatin and the flotillins are present as independently organized high-order oligomers, suggesting that these complexes act as separate scaffolding components at the cytoplasmic face of erythrocyte lipid rafts...
  5. Frick M, Bright N, Riento K, Bray A, Merrified C, Nichols B. Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding. Curr Biol. 2007;17:1151-6 pubmed
    ..Key attributes of this machinery are the dependence on coassembly of both flotillins and the inference that flotillin microdomains can exist in either flat or invaginated states. ..
  6. Langhorst M, Solis G, Hannbeck S, Plattner H, Stuermer C. Linking membrane microdomains to the cytoskeleton: regulation of the lateral mobility of reggie-1/flotillin-2 by interaction with actin. FEBS Lett. 2007;581:4697-703 pubmed
  7. Langhorst M, Reuter A, Jaeger F, Wippich F, Luxenhofer G, Plattner H, et al. Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2. Eur J Cell Biol. 2008;87:211-26 pubmed publisher
    ..Thus, regulated vesicular cycling might be a general feature of SPFH protein-dependent trafficking. ..
  8. Schneider A, Rajendran L, Honsho M, Gralle M, Donnert G, Wouters F, et al. Flotillin-dependent clustering of the amyloid precursor protein regulates its endocytosis and amyloidogenic processing in neurons. J Neurosci. 2008;28:2874-82 pubmed publisher
    ..Together, our data suggest that cholesterol/flotillin-dependent clustering of APP may stimulate the internalization into a specialized clathrin-dependent endocytosis pathway to promote amyloidogenic processing. ..
  9. Ait Slimane T, Galmes R, Trugnan G, Maurice M. Basolateral internalization of GPI-anchored proteins occurs via a clathrin-independent flotillin-dependent pathway in polarized hepatic cells. Mol Biol Cell. 2009;20:3792-800 pubmed publisher
    ..The use of distinct endocytic pathways may explain, at least in part, the different rates of transcytosis between transmembrane and GPI-anchored proteins. ..
  10. Berger T, Ueda T, Arpaia E, Chio I, Shirdel E, Jurisica I, et al. Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model. Oncogene. 2013;32:4989-94 pubmed publisher
    ..Flotillin-2 (Flot2), together with flotillin-1, is a marker for lipid raft microdomains distinct from caveolar lipid rafts, and has ..
  11. Solomon S, Masilamani M, Rajendran L, Bastmeyer M, Stuermer C, Illges H. The lipid raft microdomain-associated protein reggie-1/flotillin-2 is expressed in human B cells and localized at the plasma membrane and centrosome in PBMCs. Immunobiology. 2002;205:108-19 pubmed
    ..Since reggie/flotillin proteins co-cluster with the T cell receptor and fyn kinases upon T cell stimulation, our findings of reggie-1/flotillin-2 in B cells suggest a similar role in B cell function. ..
  12. Babuke T, Ruonala M, Meister M, Amaddii M, Genzler C, Esposito A, et al. Hetero-oligomerization of reggie-1/flotillin-2 and reggie-2/flotillin-1 is required for their endocytosis. Cell Signal. 2009;21:1287-97 pubmed publisher
    ..Based on our findings, we propose a model according to which reggie hetero-oligomers are dynamic, and changes in the size of the hetero-oligomers result in endocytosis of the complex from the plasma membrane. ..
  13. Rajendran L, Beckmann J, Magenau A, Boneberg E, Gaus K, Viola A, et al. Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLoS ONE. 2009;4:e8290 pubmed publisher
    ..Based on our results, we propose that in hematopoietic cells, flotillins provide intrinsic cues that govern segregation of certain microdomain-associated molecules during immune cell polarization...
  14. Ge L, Qi W, Wang L, Miao H, Qu Y, Li B, et al. Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. Proc Natl Acad Sci U S A. 2011;108:551-6 pubmed publisher
  15. Solis G, Hülsbusch N, Radon Y, Katanaev V, Plattner H, Stuermer C. Reggies/flotillins interact with Rab11a and SNX4 at the tubulovesicular recycling compartment and function in transferrin receptor and E-cadherin trafficking. Mol Biol Cell. 2013;24:2689-702 pubmed publisher
    ..Together our results identify reggie-1 as a regulator of the Rab11a/SNX4-controlled sorting and recycling pathway, which is, like reggies, evolutionarily conserved. ..
  16. Wang X, Yang Q, Guo L, Li X, Zhao X, Song L, et al. Flotillin-2 is associated with breast cancer progression and poor survival outcomes. J Transl Med. 2013;11:190 pubmed publisher
    Flotillin-2 (FLOT2) has been implicated in several signaling pathways in tumor cells. Our study aimed to investigate the expression pattern and clinicopathological significance of FLOT2 in patients with breast cancer...
  17. Dimković N, Djukanović L, Marinković J, Djurić Å, Knežević V, Lazarević T, et al. Achievement of guideline targets in elderly patients on hemodialysis: a multicenter study. Int Urol Nephrol. 2015;47:1555-63 pubmed publisher
    ..They used ESA and phosphate binders less frequently than younger patients (p < 0.001 and p = 0.002)...
  18. Riwaldt S, Monici M, Graver Petersen A, Birk Jensen U, Evert K, Pantalone D, et al. Preparation of A Spaceflight: Apoptosis Search in Sutured Wound Healing Models. Int J Mol Sci. 2017;18: pubmed publisher
    To prepare the ESA (European Space Agency) spaceflight project "Wound healing and Sutures in Unloading Conditions", we studied mechanisms of apoptosis in wound healing models based on ex vivo skin tissue cultures, kept for 10 days alive ..
  19. You X, Xue Q, Fang Y, Liu Q, Zhang C, Zhao C, et al. Preventive effects of Ecliptae Herba extract and its component, ecliptasaponin A, on bleomycin-induced pulmonary fibrosis in mice. J Ethnopharmacol. 2015;175:172-80 pubmed publisher
    ..5, 1.25, 0.625 g/kg and eclipta saponin A (ESA) at 80 mg/kg once daily for 28 day...
  20. Silverberg D, Wexler D, Iaina A, Schwartz D. The correction of anemia in patients with the combination of chronic kidney disease and congestive heart failure may prevent progression of both conditions. Clin Exp Nephrol. 2009;13:101-106 pubmed publisher
    ..These studies frequently showed that erythropoietic stimulating agents (ESA) with oral or IV iron often resulted in improvement in left ventricular systolic and diastolic function, dilation, ..
  21. Serizawa K, Yogo K, Tashiro Y, Aizawa K, Kawasaki R, Hirata M, et al. Epoetin beta pegol prevents endothelial dysfunction as evaluated by flow-mediated dilation in chronic kidney disease rats. Eur J Pharmacol. 2015;767:10-6 pubmed publisher
    ..risk factors for cardiovascular events in CKD patients, and treatment with erythropoiesis-stimulating agent (ESA) has been reported to improve the quality of life in CKD patients...
  22. Tsuma Y, Mori J, Ota T, Kawabe Y, Morimoto H, Fukuhara S, et al. Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR/STAT pathway. Biochem Biophys Res Commun. 2018;: pubmed publisher
    ..Furthermore, the effect of long acting erythropoiesis stimulating agents (ESA) on metabolism has not been poorly understood...
  23. Zhang J, Xiong B, Qiu J, Tan Q, Zhang Y, Yang J, et al. [Effects of adipose-derived stem cells and endothelial cells on survival and neovascularization of fat tissue transplants]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018;32:1074-1080 pubmed publisher
    ..05),adscs 组及 adscs+ecs 组间比较差异无统计学意义( p>0.05)。. adscs 可提高移植脂肪存活率,且该促进作用可能与促进血管新生相关。. ..
  24. Lu J, Zhao X, Paiardini A, Lang Y, Bottillo I, Shao L. Familial hypomagnesaemia, Hypercalciuria and Nephrocalcinosis associated with a novel mutation of the highly conserved leucine residue 116 of Claudin 16 in a Chinese patient with a delayed diagnosis: a case report. BMC Nephrol. 2018;19:181 pubmed publisher
    ..first extracellular segment (ESC1) of claudin 16 might be essential for stabilization of the appropriately folded ECS1 structure and conservation of normal claudin 16 function...
  25. Nangaku M, Mimura I, Yamaguchi J, Higashijima Y, Wada T, Tanaka T. Role of uremic toxins in erythropoiesis-stimulating agent resistance in chronic kidney disease and dialysis patients. J Ren Nutr. 2015;25:160-3 pubmed publisher
    ..Although erythropoiesis-stimulating agent (ESA) resistance is generally defined as lack of responses to exogenous ESA administration, suppression of endogenous ..
  26. Lewis S, Brannan L, Guri A, Lu P, Hontecillas R, Bassaganya Riera J, et al. Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ. PLoS ONE. 2011;6:e24031 pubmed publisher
    ..With our combined methods, we have identified α-eleostearic acid (ESA) as a natural PPARγ agonist. Results of ligand-binding assays complemented the screening prediction...
  27. Rowe F, Noonan C. Botulinum toxin for the treatment of strabismus. Cochrane Database Syst Rev. 2012;:CD006499 pubmed publisher
    ..We manually searched the Australian Orthoptic Journal and British and Irish Orthoptic Journal and ESA, ISA and IOA conference proceedings...
  28. Tseng J, Yang C, Yang S, Lin J, Lin C, Jiang J. Circulating CD133(+)/ESA(+) cells in colorectal cancer patients. J Surg Res. 2015;199:362-70 pubmed publisher
    ..The status of tumor initiating cells was measured using the surface markers CD133 (prominin-1) and ESA (epithelial-specific antigen)...
  29. Park M, Kim N, Wu L, Yu G, Park K. Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells. Biochem Biophys Res Commun. 2016;476:237-244 pubmed publisher
    ..Our results suggest that flot-1 and -2 are partially involved in CME of M3R by facilitating its internalization. ..
  30. Jiu J, An X, Li J, Leng J, Lü W, Chen L, et al. Intense red up-conversion luminescence and dynamical processes observed in Sc2O3:Yb3+,Er3+ nanostructures. Dalton Trans. 2017;46:15954-15960 pubmed publisher
    ..e. excited-state absorption (ESA), two-step energy transfer up-conversion (ET) and non-multiphonon relaxation mechanism from the (2H..
  31. Akizawa T, Tsubakihara Y, Hirakata H, Watanabe Y, Hase H, Nishi S, et al. A prospective observational study of early intervention with erythropoietin therapy and renal survival in non-dialysis chronic kidney disease patients with anemia: JET-STREAM Study. Clin Exp Nephrol. 2016;20:885-895 pubmed publisher
    ..48; 95 % CI, 0.91-2.40; P = 0.11). Initiation of ESA therapy when Hb levels decreased below 11 g/dL but not below 10 g/dL could be more effective at reducing the risk ..
  32. Ramírez Uribe N, Hernández Martínez C, López Hernández G, Pérez García M, Ramírez Sánchez E, Espinosa Padilla S, et al. [Hematopoietic progenitors transplantation in a patient with chronic granulomatous disease in Mexico]. Rev Alerg Mex. 2016;63:95-103 pubmed
    ..el Instituto Nacional de Pediatría, a partir de 2009 se implementó un proyecto para facilitar el diagnóstico de esa enfermedad...
  33. Chiba Y, Sato S, Itamochi H, Suga Y, Fukagawa T, Oumi N, et al. Establishment and characterization of a novel uterine carcinosarcoma cell line, TU-ECS-1, with mutations of TP53 and KRAS. Hum Cell. 2017;30:140-148 pubmed publisher
    ..These results suggested that TU-ECS-1 cells might have both epithelial and mesenchymal characteristics. This cell line may be useful to study the carcinogenesis of UCS and contribute to the development of novel treatment strategies. ..
  34. Fernandez Letamendi N, Fernández Letamendi T, Montañes Gracia M, Recaséns Flores V. [Erythropoiesis stimulating agents: Literature review of uses and indications in advanced oncological and non-oncological disease in the elderly]. Rev Esp Geriatr Gerontol. 2018;53:223-228 pubmed publisher
    ..consensus guidelines on each of the following diseases in which could pose the treatment of anaemia associated with ESA. A review was also carried out on the main Spanish, European and American consensus guidelines regarding the ..
  35. Louw E, Chothia M. Residual renal function in chronic dialysis is not associated with reduced erythropoietin-stimulating agent dose requirements: a cross-sectional study. BMC Nephrol. 2017;18:336 pubmed publisher
    ..common problem in patients with end-stage kidney disease (ESKD) and the use of erythropoietin-stimulating agents (ESA) has revolutionised its treatment...
  36. Timpano M, Fontana D, Rolle L, Preto M, Falcone M, Sibona M, et al. [Sperm collection for medically assisted procreation in azoospermic patients]. Urologia. 2014;81 Suppl 23:S27-31 pubmed publisher
    ..methodologies and techniques, which can be divided into percutaneous techniques and open surgical (TeSE and ESA) or micro-surgical (micro-TeSE) techniques...
  37. Šimetić L, Zibar L. Laboratory use of hepcidin in renal transplant recipients. Biochem Med (Zagreb). 2016;26:34-52 pubmed publisher
    ..However, there is an association between higher doses of erythropoiesis-stimulating agents (ESA) and mortality in the posttransplant period and the assumption that hepcidin might play a role in ESA resistance in ..
  38. Ma J, Mewes J, Harris K, Dore T, Phillips D, Dreuw A. Unravelling the early photochemical behavior of (8-substituted-7-hydroxyquinolinyl)methyl acetates through electronic structure theory and ultrafast transient absorption spectroscopy. Phys Chem Chem Phys. 2017;19:1089-1096 pubmed publisher
    ..states involved in the photochemistry were identified by means of their characteristic excited state absorption (ESA) bands and from second order coupled-cluster (CC2) calculations...
  39. Santra S, Das D, Das N, Nanda K. An efficient on-board metal-free nanocatalyst for controlled room temperature hydrogen production. Chem Sci. 2017;8:2994-3001 pubmed publisher
    ..is essential for the hydrolysis for hydrogen production, but the overall activity is found to be enhanced with the ESA. A maximum value of 1066 ml g-1 min-1 as the turnover frequency is obtained which is moderate ..
  40. Di Iorio B, Di Micco L, Bruzzese D, Nardone L, Russo L, Formisano P, et al. Ultrapure dialysis water obtained with additional ultrafilter may reduce inflammation in patients on hemodialysis. J Nephrol. 2017;30:795-801 pubmed publisher
    ..inflammation and ameliorate hemoglobin levels, with a consequent reduction in erythropoietin-stimulating agents (ESA). An ultrafilter, composed of two serially positioned devices with polysulfone membranes of 2.0 and 1...
  41. Guillaume E, Comunale F, Do Khoa N, Planchon D, Bodin S, Gauthier Rouvière C. Flotillin microdomains stabilize cadherins at cell-cell junctions. J Cell Sci. 2013;126:5293-304 pubmed publisher
    ..Altogether, these data demonstrate that flotillin microdomains are required for cadherin stabilization at CCJs and for the formation of functional CCJs. ..
  42. Poonawalla I, Piller L, Lairson D, Chan W, Du X. Use of Hematopoietic Growth Factors and Risk of Thromboembolic and Pulmonary Toxicities in Elderly Patients with Advanced Ovarian Cancer. Womens Health Issues. 2016;26:574-83 pubmed publisher
    ..e., erythropoietin-stimulating agent [ESA] and/or colony-stimulating factor [CSF]) in a community-dwelling cohort of elderly patients with advanced ovarian ..
  43. Kim Y, Kim H, Kwon Y, Ryu D, Lee M, Park K, et al. Association between Vitamin D Deficiency and Anemia in Patients with End-Stage Renal Disease: A Cross-Sectional Study. Yonsei Med J. 2016;57:1159-64 pubmed publisher
    ..Using multivariate regression models, 25(OH)D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH)D3: ?=0.263, p<0...
  44. Gong X, Gu X, Chen Y, Zhu H, Xia Z, Li J, et al. Chronic preclinical safety evaluation of EPO-018B, a pegylated peptidic erythropoiesis-stimulating agent in monkeys and rats. Toxicol Appl Pharmacol. 2016;307:45-61 pubmed publisher
    EPO-018B, a synthetic peptide-based erythropoiesis stimulating agent (ESA), is mainly designed for treatment of anemia caused by chronic renal failure and chemotherapy against cancer...
  45. Han J, Lachance C, Ricketts M, McCullough C, Gerace M, Black B, et al. The scaffolding protein JADE1 physically links the acetyltransferase subunit HBO1 with its histone H3-H4 substrate. J Biol Chem. 2018;293:4498-4509 pubmed publisher
    ..histone acetyltransferase (HAT) complex that also contains inhibitor of growth family member (ING) 4/5, MYST/Esa1-associated factor (MEAF) 6, and the scaffolding proteins Jade family PHD finger (JADE) 1/2/3 or bromodomain and PHD ..
  46. Lamoureux Lamarche C, Vasiliadis H. Lifetime traumatic events, health-related quality of life, and satisfaction with life in older adults. Qual Life Res. 2017;26:2683-2692 pubmed publisher
    ..Data used came from the ESA-Services study (2011-2013) and included a large convenience sample of 1811 older adults...
  47. Radić J, Basic Jukic N, Vujicic B, Klarić D, Radulović G, Jakić M, et al. Anemia Is Correlated with Malnutrition and Inflammation in Croatian Peritoneal Dialysis Patients: A Multicenter Nationwide Study. Perit Dial Int. 2017;37:472-475 pubmed publisher
    ..Statistically significant correlations between MIS and erythropoietin weekly dose per kg of body weight (ESA weekly dose), hemoglobin (Hb), and erythrocytes were found (r = 0.439, p < 0.001; r = -0...
  48. Kihara M, Matsuo Tezuka Y, Noguchi Sasaki M, Yorozu K, Kurasawa M, Shimonaka Y, et al. Visualization of 57Fe-Labeled Heme Isotopic Fine Structure and Localization of Regions of Erythroblast Maturation in Mouse Spleen by MALDI FTICR-MS Imaging. J Am Soc Mass Spectrom. 2017;28:2469-2475 pubmed publisher
    ..E.R.A.), or methoxy-polyethylene glycol-modified epoetin beta, is a long-acting erythropoiesis stimulating agent (ESA) that effectively maintains hemoglobin levels...
  49. Rajasekharan S, Vercruysse C, Martens L, Verbeeck R. Effect of Exposed Surface Area, Volume and Environmental pH on the Calcium Ion Release of Three Commercially Available Tricalcium Silicate Based Dental Cements. Materials (Basel). 2018;11: pubmed publisher
    ..The aim of this study was to determine the effect of volume (Vol), exposed surface area (ESA) and pH of surrounding medium on calcium ion release...
  50. Nassif M, Patel J, Shuster J, Raymer D, Jackups R, Novak E, et al. Clinical outcomes with use of erythropoiesis stimulating agents in patients with the HeartMate II left ventricular assist device. JACC Heart Fail. 2015;3:146-53 pubmed publisher
    This study evaluated clinical outcomes associated with erythropoiesis stimulating agent (ESA) use in left ventricular assist devices (LVAD)-supported patients...
  51. Kawahara K, Minakuchi J, Yokota N, Suekane H, Tsuchida K, Kawashima S. Treatment of renal anaemia with erythropoiesis-stimulating agents in predialysis chronic kidney disease patients: Haemoglobin profile during the 6 months before initiation of dialysis. Nephrology (Carlton). 2015;20 Suppl 4:29-32 pubmed publisher
    ..dialysis at Kawashima Hospital between 1 January 2009 and 28 February 2015 and who received only one kind of ESA for at least 6 months before initiation of dialysis...
  52. Kuwahara M, Arai Y, Takehara E, Sasaki Y, Yoshimine T, Kusaka K, et al. Early response to erythropoiesis-stimulating agents in non-dialysis chronic kidney disease patients. Clin Exp Nephrol. 2016;20:585-594 pubmed publisher
    ..After the initial 12-week administration of ESAs, ΔHb/ESA dose/kg was calculated as an index of efficacy of each ESA...
  53. Yousaf F, Spinowitz B. Hypoxia-Inducible Factor Stabilizers: a New Avenue for Reducing BP While Helping Hemoglobin?. Curr Hypertens Rep. 2016;18:23 pubmed publisher
    ..Erythropoiesis-stimulating agents (ESA) are the mainstay of anemia management but their use is limited due to the associated cardiovascular adverse events...
  54. Warady B, Barcia J, Benador N, Jankauskiene A, Olson K, Podracka L, et al. De novo weekly and biweekly darbepoetin alfa dosing in pediatric patients with chronic kidney disease. Pediatr Nephrol. 2018;33:125-137 pubmed publisher
    Darbepoetin alfa is a commonly prescribed erythropoiesis-stimulating agent (ESA) for correcting anemia in pediatric chronic kidney disease (CKD) patients. However, little information exists on its use in ESA-naïve patients...
  55. Altieri F, Filacchione G, Capaccioni F, Carli C, Dami M, Tommasi L, et al. The pre-launch characterization of SIMBIO-SYS/VIHI imaging spectrometer for the BepiColombo mission to Mercury. II. Spectral calibrations. Rev Sci Instrum. 2017;88:094503 pubmed publisher
    ..and near Infrared Hyperspectral Imager (VIHI) is the VIS-IR spectrometer with imaging capabilities aboard the ESA BepiColombo mission to Mercury...
  56. Stephens J, Emerson L, Spry L, Caloyeras J, Anderson E, Reitan J, et al. Time savings of weekly versus three-times-per-week administration of erythropoiesis stimulating agents in United States dialysis patients. Curr Med Res Opin. 2016;32:313-20 pubmed publisher
    Previous research suggests that erythropoiesis stimulating agent (ESA) administration in dialysis is a time-consuming task and switching to less frequently dosed ESAs may offer operational efficiencies...
  57. Faridi N, Bathaie S, Abroun S, Farzaneh P, Karbasian H, Tamanoi F, et al. Isolation and characterization of the primary epithelial breast cancer cells and the adjacent normal epithelial cells from Iranian women's breast cancer tumors. Cytotechnology. 2018;70:625-639 pubmed publisher
    ..the positive immunoreactivity of the isolated epithelial cells against CD24 and Epithelial Specific Antigen (ESA/EpCAM), while they displayed a concomitant low expression of CD44 and CD49f...
  58. Yan Y, Yang F, Zhang H, Che J, Zheng J. Up-regulation of flotillin-2 is associated with renal cell carcinoma progression. Tumour Biol. 2014;35:10479-86 pubmed publisher
    Flotillin-2 (FLOT2) is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathway...
  59. Houston B, Jayakar J, Wells R, Lenis M, Zhang L, Zhu N, et al. A predictive model of response to erythropoietin stimulating agents in myelodysplastic syndrome: from the Canadian MDS patient registry. Ann Hematol. 2017;96:2025-2029 pubmed publisher
    ..in a larger cohort and determine if other variables such as IPSS/IPSS-R, ferritin, LDH, and a novel European ESA response score (Santini 2013) were of prognostic importance...
  60. Liu W, Liu X, Wang L, Zhu B, Zhang C, Jia W, et al. PLCD3, a flotillin2-interacting protein, is involved in proliferation, migration and invasion of nasopharyngeal carcinoma cells. Oncol Rep. 2018;39:45-52 pubmed publisher
    ..In our previous study, we demonstrated that flotillin2 (Flot2) plays a pro-neoplastic role in NPC and is involved in tumour progression and metastasis...
  61. Robinson B, Larkina M, Bieber B, Kleophas W, Li Y, Locatelli F, et al. Evaluating the effectiveness of IV iron dosing for anemia management in common clinical practice: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). BMC Nephrol. 2017;18:330 pubmed publisher
    ..to gain insight into optimal IV iron dosing by estimating the effects of IV iron doses on Hgb, TSAT, ferritin, and ESA dose in common clinical practice...
  62. Li Y, Wang J, Liu Y, Qiu L, Li J, Hu H, et al. Esculentoside A specifically binds to ribosomal protein S3a and impairs LPS-induced signaling in macrophages. Int Immunopharmacol. 2018;54:254-260 pubmed publisher
    Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, is reported as a potent suppressor of pro-inflammatory functions of macrophages...
  63. Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Kruger M, et al. The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Mol Biol Cell. 2011;22:202-15 pubmed publisher
    ..In sum, we identify the kinesin KIF9 and reggie/flotillin proteins as novel regulators of macrophage podosomes and show that their interaction is critical for the matrix-degrading ability of these structures. ..
  64. Li Y, Martin B, Cravatt B, Hofmann S. DHHC5 protein palmitoylates flotillin-2 and is rapidly degraded on induction of neuronal differentiation in cultured cells. J Biol Chem. 2012;287:523-30 pubmed publisher
    ..These findings suggest that protein palmitoylation can be regulated through changes in DHHC PAT levels in response to differentiation signals. ..
  65. Afsar B. The relationship between depressive symptoms and erythropoietin resistance in stable hemodialysis patients with adequate iron stores. Int J Artif Organs. 2013;36:314-9 pubmed publisher
    ..In the current study, the relationship between depressive symptoms and EPO resistance as evaluated by erythropoiesis stimulating agent (ESA) hyporesponsiveness index (EHRI) was analyzed. ?
  66. Xie G, Li J, Chen J, Tang X, Wu S, Liao C. Knockdown of flotillin-2 impairs the proliferation of breast cancer cells through modulation of Akt/FOXO signaling. Oncol Rep. 2015;33:2285-90 pubmed publisher
    ..Flotillin-2 (FLOT2), a marker of lipid rafts, is involved in the progression of cancer, yet the precise mechanism remains unclear...
  67. Perez Garcia R, Varas J, Cives A, Martin Malo A, Aljama P, Ramos R, et al. Increased mortality in haemodialysis patients administered high doses of erythropoiesis-stimulating agents: a propensity score-matched analysis. Nephrol Dial Transplant. 2017;: pubmed publisher
    ..The issue of ESA safety has been raised in multiple studies, with correlates derived for elevated cancer incidence and mortality...
  68. Kubheka G, Sanusi K, Mack J, Nyokong T. Optical limiting properties of 3,5-dipyrenylvinyleneBODIPY dyes at 532nm. Spectrochim Acta A Mol Biomol Spectrosc. 2018;191:357-364 pubmed publisher
    ..to incident pulsed laser light that is consistent with a two photon absorption-assisted excited state absorption (ESA) mechanism in CH2Cl2 solution and when the dyes are embedded in poly(bisphenol carbonate A) (..
  69. Wang Y, Yao W, Guo L, Xi H, Li S, Wang Z. Expression of flotillin-2 in human non-small cell lung cancer and its correlation with tumor progression and patient survival. Int J Clin Exp Pathol. 2015;8:601-7 pubmed
    Recent studies have revealed that flotillin-2 (FLOT2) played important roles in cancer progression...
  70. Wen Q, Wang W, Chu S, Luo J, Chen L, Xie G, et al. Flot-2 Expression Correlates with EGFR Levels and Poor Prognosis in Surgically Resected Non-Small Cell Lung Cancer. PLoS ONE. 2015;10:e0132190 pubmed publisher
    We previously reported that expression of Flotillin 2 (Flot-2), a protein isolated from caveolae/lipid raft domains, increased significantly in nasopharyngeal carcinoma (NPC) compared with normal tissues...
  71. Saglimbene V, Palmer S, Ruospo M, Natale P, Craig J, Strippoli G. Continuous erythropoiesis receptor activator (CERA) for the anaemia of chronic kidney disease. Cochrane Database Syst Rev. 2017;8:CD009904 pubmed publisher
    Continuous erythropoiesis receptor activator (CERA) is a newer, longer acting ESA which might be preferred to other ESAs (epoetin or darbepoetin) based on its lower frequency of administration...
  72. Modrek S, Sieverding M. Mother, Daughter, Doctor: Medical Professionals and Mothers' Decision Making About Female Genital Cutting in Egypt. Int Perspect Sex Reprod Health. 2016;42:81-92 pubmed publisher
    ..por profesionales médicos o el grado en el que tales profesionales pueden influir en las decisiones relativas a esa práctica...
  73. Gao Q, Zribi M, Escorihuela M, Baghdadi N. Synergetic Use of Sentinel-1 and Sentinel-2 Data for Soil Moisture Mapping at 100 m Resolution. Sensors (Basel). 2017;17: pubmed publisher
    The recent deployment of ESA's Sentinel operational satellites has established a new paradigm for remote sensing applications...
  74. Kuykendall A, Talati C, Al Ali N, Sweet K, Padron E, Sallman D, et al. The Treatment Landscape of Myelofibrosis Before and After Ruxolitinib Approval. Clin Lymphoma Myeloma Leuk. 2017;17:e45-e53 pubmed publisher
    ..symptoms and/or splenomegaly, increased use of ruxolitinib was associated with decreased use of first-line ESA (P = .03) or thalidomide (P = .03)...
  75. Korzeniewski B. Contribution of proton leak to oxygen consumption in skeletal muscle during intense exercise is very low despite large contribution at rest. PLoS ONE. 2017;12:e0185991 pubmed publisher
    ..oxidative ATP supply and [Formula: see text] related to it, was mostly stimulated by high each-step activation (ESA) of OXPHOS complexes...
  76. Lemmerz C, Lux O, Reitebuch O, Witschas B, Wührer C. Frequency and timing stability of an airborne injection-seeded Nd:YAG laser system for direct-detection wind lidar. Appl Opt. 2017;56:9057-9068 pubmed publisher
    ..laser deployed in the airborne demonstrator Doppler wind lidar for the Aeolus mission of the European Space Agency (ESA)...
  77. Schroeder W, Siciliano M, Stewart Galetka S, Duvic M. The human gene for an epidermal surface antigen (M17S1) is located at 17q11-12. Genomics. 1991;11:481-2 pubmed
  78. Nebl T, Pestonjamasp K, Leszyk J, Crowley J, Oh S, Luna E. Proteomic analysis of a detergent-resistant membrane skeleton from neutrophil plasma membranes. J Biol Chem. 2002;277:43399-409 pubmed
    ..Other DRM-H components include lipid raft-associated integral membrane proteins (stomatin, flotillin 1, and flotillin 2), extracellular surface-bound and glycophosphatidylinositol-anchored proteins (IgM, membrane-type 6 matrix ..
  79. Meister M, Zuk A, Tikkanen R. Role of dynamin and clathrin in the cellular trafficking of flotillins. FEBS J. 2014;281:2956-76 pubmed publisher
    ..These data show that clathrin and dynamin are required for the endosomal sorting of flotillins, and the study provides a mechanistic dissection of the thus far poorly characterized endosomal trafficking of flotillins. ..
  80. Kim Y, Lee H, Jung D, Kim J, Song S. The DNA aptamer binds stemness-enriched cancer cells in pancreatic cancer. J Mol Recognit. 2017;30: pubmed publisher
    ..The colocalization of CD44, CD24, ESA, and CD133 was also observed in the aptamer-positive cells by confocal microscopy...
  81. Matamoros V, Rodriguez Y. Influence of seasonality and vegetation on the attenuation of emerging contaminants in wastewater effluent-dominated streams. A preliminary study. Chemosphere. 2017;186:269-277 pubmed publisher
    ..The attenuation of ECs 1 km downstream ranged from no removal to up to 80% (48% on average)...
  82. Massamba V, Vasiliadis H, Preville M. Determinants of follow-up care associated with incident antidepressant use in older adults. BMC Res Notes. 2017;10:419 pubmed publisher
    ..The study included secondary analyses of data collected in the Étude sur la Santé des Aînés (ESA) Services study on older adults recruited while consulting in primary care clinics in one of the largest health ..
  83. Kandil O, Gamil I, Hendawy S, Medhat F, El Habit O. Efficacy of glutathione-S-transferase purified antigen of the gastro-intestinal nematode Haemonchus contortus in diagnosis of sheep haemonchosis. J Parasit Dis. 2017;41:968-975 pubmed publisher
    ..Different H. contortus antigens; crude somatic antigen (CSA), excretory/secretory antigen (ESA), crude larval antigen (CLA), glutathione-S-transferase antigen (GST) and recombinant protein (rhcp 26/23) were ..
  84. Khan S, Mazumdar S. Theory of Transient Excited State Absorptions in Pentacene and Derivatives: The Triplet-Triplet Biexciton Versus Free Triplets. J Phys Chem Lett. 2017;: pubmed publisher
    ..We predict additional weak ESA from the triplet-triplet, but not from the triplet, at still lower energy.
  85. O Hara M, Murray N, Carter J, Kellogg C, Link J. Hydroxamate column-based purification of zirconium-89 (89Zr) using an automated fluidic platform. Appl Radiat Isot. 2018;132:85-94 pubmed publisher
    ..The effective specific activity (ESA) ranged between 44(7) and 109(22) TBq·mmole-1, while the bindable metals concentration, a metric ..
  86. Su Y, Lai H, Chang Y, Chen G, Lee J. Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J. 2011;30:3186-99 pubmed publisher
  87. Roger S, Tio M, Park H, Choong H, Goh B, Cushway T, et al. Intravenous iron and erythropoiesis-stimulating agents in haemodialysis: A systematic review and meta-analysis. Nephrology (Carlton). 2017;22:969-976 pubmed publisher
    ..Intravenous iron is used to optimize ESA response and reduces ESA doses in haemodialysis patients; this meta-analysis evaluates the magnitude of this effect.
  88. García de Lorenzo Y Mateos A. Seventh Jesús Culebras Lecture. Systemic inflammatory response and multi organic dysfunction/failure following aggression: metabolic implications. Nutr Hosp. 2017;34:244-250 pubmed publisher
    ..Como resultado de esa compleja respuesta metabólica, el control de la utilización de los sustratos energéticos está solo parcialmente ..
  89. Carbonnelle D, Luu T, Chaillou C, Huvelin J, Bard J, Nazih H. LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells. Anticancer Res. 2017;37:4067-4073 pubmed
    ..T0901317 on integrity of MCF-7 lipid rafts was examined by studying the expression of rafts marker flotillin-2 (FLOT2) and DHHC5, which palmitoylates FLOT2, and by studying the expression of phospho-Akt...
  90. Bowman D, Asher J, Fischer S, Cramer C, Govind N. Excited-state absorption in tetrapyridyl porphyrins: comparing real-time and quadratic-response time-dependent density functional theory. Phys Chem Chem Phys. 2017;19:27452-27462 pubmed publisher
    ..and B bands of the ground-state absorption (GSA), which has been attributed to increased excited-state absorption (ESA) relative to GSA...
  91. Desharnais P, Naud J, Ayotte C. Immunomagnetic beads-based isolation of erythropoietins from urine and blood for sports anti-doping control. Drug Test Anal. 2017;: pubmed publisher
    According to the World Anti-Doping Agency (WADA) technical document for erythropoiesis stimulating agents (ESA) analysis (TD2014EPO), double-blotting of serum/plasma samples is mandatory for all analysis by isoelectric focusing (IEF) and ..
  92. Reyero Saavedra M, Qiao Z, Sánchez Correa M, Díaz Pineda M, Reyes J, Covarrubias A, et al. Gene Silencing of Argonaute5 Negatively Affects the Establishment of the Legume-Rhizobia Symbiosis. Genes (Basel). 2017;8: pubmed publisher
    ..critical symbiotic genes: Nuclear Factor Y-B (NF-YB), Nodule Inception (NIN) and Flotillin2 (FLOT2)...