Gene Symbol: FLNA
Description: filamin A
Alias: ABP-280, ABPX, CSBS, CVD1, FGS2, FLN, FLN-A, FLN1, FMD, MNS, NHBP, OPD, OPD1, OPD2, XLVD, XMVD, filamin-A, actin binding protein 280, alpha-filamin, endothelial actin-binding protein, filamin A, alpha, filamin-1, non-muscle filamin
Species: human
Products:     FLNA

Top Publications

  1. Garcia E, Stracher A, Jay D. Calcineurin dephosphorylates the C-terminal region of filamin in an important regulatory site: a possible mechanism for filamin mobilization and cell signaling. Arch Biochem Biophys. 2006;446:140-50 pubmed
  2. van der Ven P, Wiesner S, Salmikangas P, Auerbach D, Himmel M, Kempa S, et al. Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin. J Cell Biol. 2000;151:235-48 pubmed
    ..Since defects in the myotilin gene were recently reported to cause a form of autosomal dominant limb-girdle muscular dystrophy, our findings provide a further contribution to the molecular understanding of this disease. ..
  3. Sheen V, Dixon P, Fox J, Hong S, Kinton L, Sisodiya S, et al. Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females. Hum Mol Genet. 2001;10:1775-83 pubmed
    ..Previous analysis showed heterozygous mutations in the X-linked gene filamin 1 (FLN1), but examined only the first six (of 48) coding exons of the gene and hence did not assess the incidence ..
  4. Gorlin J, Henske E, Warren S, Kunst C, D Urso M, Palmieri G, et al. Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. Genomics. 1993;17:496-8 pubmed
    ..We have mapped the ABP-280 filamin gene (FLN) to Xq28 by Southern blot analysis of somatic cell hybrid lines, by fluorescence in situ hybridization, and through ..
  5. Nakamura F, Hartwig J, Stossel T, Szymanski P. Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J Biol Chem. 2005;280:32426-33 pubmed
    b>Filamin A (FLNa) cross-links actin filaments (F-actin) into three-dimensional gels in cells, attaches F-actin to membrane proteins, and is a scaffold that collects numerous and diverse proteins...
  6. Gorlin J, Yamin R, Egan S, Stewart M, Stossel T, Kwiatkowski D, et al. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol. 1990;111:1089-105 pubmed
    ..The large size of the leaves, their interruption by two hinges and flexible actin-binding site, facilitate cross-linking of widely dispersed actin filaments. ..
  7. Cooper J, Liu L, Woodruff E, Taylor H, Goodwin J, D Aquila R, et al. Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly. J Biol Chem. 2011;286:28498-510 pubmed publisher
    ..screening against a human cDNA library and identified the non-muscle actin filament cross-linking protein filamin A as a novel Gag binding partner...
  8. Liu G, Thomas L, Warren R, Enns C, Cunningham C, Hartwig J, et al. Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997;139:1719-33 pubmed
    ..The novel roles of ABP-280 and the cytoskeleton in the sorting of furin in the TGN/ endosomal system and the formation of proprotein processing compartments are discussed. ..
  9. Pentikäinen U, Ylanne J. The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin. J Mol Biol. 2009;393:644-57 pubmed publisher
    ..This observed force-induced conformational change can also be one of possible mechanisms involved in the regulation of integrin activation. ..

More Information


  1. Lad Y, Kiema T, Jiang P, Pentikainen O, Coles C, Campbell I, et al. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 2007;26:3993-4004 pubmed
    ..Here we report the 2.5 A resolution structure of a three-domain fragment of human filamin A (IgFLNa19-21)...
  2. Sheen V, Feng Y, Graham D, Takafuta T, Shapiro S, Walsh C. Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact. Hum Mol Genet. 2002;11:2845-54 pubmed
    Mutations in the X-linked gene Filamin A (FLNA) lead to the human neurological disorder, periventricular heterotopia (PH)...
  3. Ghosh S, Ahrens W, Phatak S, Hwang S, Schrum L, Bonkovsky H. Association of filamin A and vimentin with hepatitis C virus proteins in infected human hepatocytes. J Viral Hepat. 2011;18:e568-77 pubmed publisher
    ..Using proteomics, qRT-PCR, Western blot and immunofluorescence techniques, we revealed that filamin A (fila) and vimentin (vim) were prominently increased proteins in HCV-expressing human hepatoma cells compared ..
  4. Kato S, Ohtoko K, Ohtake H, Kimura T. Vector-capping: a simple method for preparing a high-quality full-length cDNA library. DNA Res. 2005;12:53-62 pubmed
    ..5 kbp can be cloned. This method will accelerate comprehensive gene analysis in a variety of eukaryotes. ..
  5. Ohta Y, Stossel T, Hartwig J. Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI). Cell. 1991;67:275-82 pubmed
    ..This finding suggests the existence of a pathway communicating a signal between a functional IgG receptor and intracellular components involved in the effector responses to Fc gamma RI-ligand interaction. ..
  6. Robertson S, Twigg S, Sutherland Smith A, Biancalana V, Gorlin R, Horn D, et al. Localized mutations in the gene encoding the cytoskeletal protein filamin A cause diverse malformations in humans. Nat Genet. 2003;33:487-91 pubmed
    Remodeling of the cytoskeleton is central to the modulation of cell shape and migration. Filamin A, encoded by the gene FLNA, is a widely expressed protein that regulates re-organization of the actin cytoskeleton by interacting with ..
  7. Seck T, Baron R, Horne W. Binding of filamin to the C-terminal tail of the calcitonin receptor controls recycling. J Biol Chem. 2003;278:10408-16 pubmed
  8. Velkova A, Carvalho M, Johnson J, Tavtigian S, Monteiro A. Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair. Cell Cycle. 2010;9:1421-33 pubmed
    ..Here we report the identification of the actin-binding protein Filamin A (FLNA) as BRCA1 partner and demonstrate that FLNA is required for efficient regulation of early stages of DNA ..
  9. Guerrini R, Mei D, Sisodiya S, Sicca F, Harding B, Takahashi Y, et al. Germline and mosaic mutations of FLN1 in men with periventricular heterotopia. Neurology. 2004;63:51-6 pubmed
    To describe the phenotypic spectrum and genetics of periventricular nodular heterotopia (PNH) caused by FLN1 mutations in four men...
  10. Leonardi A, Ellinger Ziegelbauer H, Franzoso G, Brown K, Siebenlist U. Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. J Biol Chem. 2000;275:271-8 pubmed
    ..Reintroduction of Filamin into these cells restores the TNF response. The data imply a role for Filamin in inflammatory signal transduction pathways. ..
  11. Enz R. The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7. FEBS Lett. 2002;514:184-8 pubmed
    ..Finally, co-expression of Filamin-A and mGluR7 splice variants was shown in brain regions. These findings suggest that Filamin-A may physically link metabotropic glutamate receptors to the actin cytoskeleton. ..
  12. Sverdlov M, Shinin V, Place A, Castellon M, Minshall R. Filamin A regulates caveolae internalization and trafficking in endothelial cells. Mol Biol Cell. 2009;20:4531-40 pubmed publisher
    ..In the present study, we test the hypothesis that interactions between F-actin cross-linking protein filamin A and caveolin-1 facilitate the internalization and trafficking of caveolae...
  13. Li M, Li C, Weingarten P, Bunzow J, Grandy D, Zhou Q. Association of dopamine D(3) receptors with actin-binding protein 280 (ABP-280). Biochem Pharmacol. 2002;63:859-63 pubmed
    ..Our results demonstrate a subtype-specific regulation of dopamine D(2)-family receptor signaling by the cytoskeletal protein ABP-280. ..
  14. Jimenez Baranda S, Gomez Mouton C, Rojas A, Martinez Prats L, Mira E, Ana Lacalle R, et al. Filamin-A regulates actin-dependent clustering of HIV receptors. Nat Cell Biol. 2007;9:838-46 pubmed
    ..Our results thus identify filamin-A as an adaptor protein that links HIV-1 receptors to the actin cytoskeleton remodelling machinery, which may facilitate virus infection. ..
  15. Zhu T, He H, Kole S, D Souza T, Agarwal R, Morin P, et al. Filamin A-mediated down-regulation of the exchange factor Ras-GRF1 correlates with decreased matrix metalloproteinase-9 expression in human melanoma cells. J Biol Chem. 2007;282:14816-26 pubmed
    The actin-binding protein filamin A (FLNa) is associated with diverse cellular processes such as cell motility and signaling through its scaffolding properties...
  16. Anilkumar G, Rajasekaran S, Wang S, Hankinson O, Bander N, Rajasekaran A. Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity. Cancer Res. 2003;63:2645-8 pubmed
    ..Cancer Res., 58: 4055-4060, 1998). In this study we demonstrate that filamin A, an actin cross-linking protein, associates with the cytoplasmic tail of PSMA and that this association of PSMA ..
  17. Nakamura F, Heikkinen O, Pentikainen O, Osborn T, Kasza K, Weitz D, et al. Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS ONE. 2009;4:e4928 pubmed publisher
    Mutations in filamin A (FLNa), an essential cytoskeletal protein with multiple binding partners, cause developmental anomalies in humans...
  18. Tigges U, Koch B, Wissing J, Jockusch B, Ziegler W. The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha. J Biol Chem. 2003;278:23561-9 pubmed
    b>Filamin A is an established structural component of cell-matrix adhesion sites. In addition, it serves as a scaffold for the subcellular targeting of different signaling molecules...
  19. Loo D, Kanner S, Aruffo A. Filamin binds to the cytoplasmic domain of the beta1-integrin. Identification of amino acids responsible for this interaction. J Biol Chem. 1998;273:23304-12 pubmed
  20. Calderwood D, Huttenlocher A, Kiosses W, Rose D, Woodside D, Schwartz M, et al. Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. Nat Cell Biol. 2001;3:1060-8 pubmed
    ..Thus, tight filamin binding restricts integrin-dependent cell migration by inhibiting transient membrane protrusion and cell polarization. ..
  21. Kim K, Gainetdinov R, Laporte S, Caron M, Barak L. G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. J Biol Chem. 2005;280:12774-80 pubmed
    ..in HEK-293 cells show that in the absence of agonist the D3R immunoprecipitates in a complex containing both filamin A and beta-arrestin2...
  22. Sheen V, Jansen A, Chen M, Parrini E, Morgan T, Ravenscroft R, et al. Filamin A mutations cause periventricular heterotopia with Ehlers-Danlos syndrome. Neurology. 2005;64:254-62 pubmed
    ..Western blotting evaluated for loss of filamin A (FLNA) protein and Southern blotting assessed for any potential chromosome rearrangement in this region...
  23. Ott I, Fischer E, Miyagi Y, Mueller B, Ruf W. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280. J Cell Biol. 1998;140:1241-53 pubmed
    ..The specific interaction of the TF cytoplasmic domain with ABP-280 provides a molecular pathway by which TF supports tumor cell metastasis and vascular remodeling. ..
  24. Nakamura F, Osborn T, Hartemink C, Hartwig J, Stossel T. Structural basis of filamin A functions. J Cell Biol. 2007;179:1011-25 pubmed
    b>Filamin A (FLNa) can effect orthogonal branching of F-actin and bind many cellular constituents...
  25. Chakarova C, Wehnert M, Uhl K, Sakthivel S, Vosberg H, van der Ven P, et al. Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family. Hum Genet. 2000;107:597-611 pubmed
    The genomic structure of the filamin gene paralogues FLNB and FLNC was determined and related to FLNA. FLNB consists of 45 exons and 44 introns and spans approximately 80 kb of genomic DNA...
  26. Shifrin Y, Arora P, Ohta Y, Calderwood D, McCulloch C. The role of FilGAP-filamin A interactions in mechanoprotection. Mol Biol Cell. 2009;20:1269-79 pubmed publisher
    ..b>Filamin A (FLNa) may protect cells from mechanically induced death by mechanisms that are not yet defined...
  27. Feng S, Reséndiz J, Lu X, Kroll M. Filamin A binding to the cytoplasmic tail of glycoprotein Ibalpha regulates von Willebrand factor-induced platelet activation. Blood. 2003;102:2122-9 pubmed
    We examined the hypothesis that filamin A binding to the cytoplasmic tail of platelet glycoprotein Ibalpha (GpIbalpha) is regulated by pathologic shear stress and modulates von Willebrand factor (VWF)-induced platelet activation...
  28. Chen H, Kolahi K, Mofrad M. Phosphorylation facilitates the integrin binding of filamin under force. Biophys J. 2009;97:3095-104 pubmed publisher
    ..We believe the results of this study implicate filamin-A as a tunable mechanosensor, where its sensitivity can be modulated by the degree of phosphorylation. ..
  29. Ohta Y, Suzuki N, Nakamura S, Hartwig J, Stossel T. The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A. 1999;96:2122-8 pubmed
    ..Either a dominant negative RalA construct or the RalA-binding domain of filamin 1 specifically block Cdc42-induced filopod formation, but a Cdc42 inhibitor does not impair RalA's effects, which, ..
  30. Williamson D, Pikovski I, Cranmer S, Mangin P, Mistry N, Domagala T, et al. Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear. J Biol Chem. 2002;277:2151-9 pubmed
    ..These studies define a critical role for amino acids within the 557-579 sequence of GPIbalpha for interaction with filamin-1. ..
  31. Hjälm G, MacLeod R, Kifor O, Chattopadhyay N, Brown E. Filamin-A binds to the carboxyl-terminal tail of the calcium-sensing receptor, an interaction that participates in CaR-mediated activation of mitogen-activated protein kinase. J Biol Chem. 2001;276:34880-7 pubmed
    ..Therefore, the binding of the CaR's COOH-terminal tail to filamin-A may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CaR-mediated activation of MAPK. ..
  32. Scott M, Pierotti V, Storez H, Lindberg E, Thuret A, Muntaner O, et al. Cooperative regulation of extracellular signal-regulated kinase activation and cell shape change by filamin A and beta-arrestins. Mol Cell Biol. 2006;26:3432-45 pubmed
    ..Here, we identify the actin-binding and scaffolding protein filamin A (FLNA) as a betaarr-binding partner using Son of sevenless recruitment system screening, a classical yeast two-..
  33. Cukier I, Li Y, Lee J. Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin. FEBS Lett. 2007;581:1661-72 pubmed
    ..In this report. we show that human cyclin B1 binds the actin cross-linking protein Filamin-A (FLNa). The proteins co-immunoprecipitate and co-localize in mitotic human cells...
  34. Onoprishvili I, Ali S, Andria M, Shpigel A, Simon E. Filamin A mutant lacking actin-binding domain restores mu opioid receptor regulation in melanoma cells. Neurochem Res. 2008;33:2054-61 pubmed publisher
    We have previously reported that the protein filamin A (FLA) binds to the carboxyl tail of the mu opioid receptor (MOPr)...
  35. Zhang M, Breitwieser G. High affinity interaction with filamin A protects against calcium-sensing receptor degradation. J Biol Chem. 2005;280:11140-6 pubmed
    ..MAPK pathway activation requires the cytoskeletal scaffold protein filamin A. Here we examine the interactions of CaR with filamin A in HEK-293 and M2 or A7 melanoma cells to determine how ..
  36. Travis M, van der Flier A, Kammerer R, Mould A, Sonnenberg A, Humphries M. Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation. FEBS Lett. 2004;569:185-90 pubmed
    ..Here, using the interaction between recombinant fragments from the C-terminus of filamin A and the cytoplasmic tail of integrin beta 7 as a model, we report a negative regulatory role for filamin ..
  37. Zenker M, Rauch A, Winterpacht A, Tagariello A, Kraus C, Rupprecht T, et al. A dual phenotype of periventricular nodular heterotopia and frontometaphyseal dysplasia in one patient caused by a single FLNA mutation leading to two functionally different aberrant transcripts. Am J Hum Genet. 2004;74:731-7 pubmed
    ..We propose that the dual phenotype is caused by two functionally different, aberrant filamin A proteins and therefore represents an exceptional model case of allelic gain-of-function and loss-of-function ..
  38. Kim H, Nakamura F, Lee W, Shifrin Y, Arora P, McCulloch C. Filamin A is required for vimentin-mediated cell adhesion and spreading. Am J Physiol Cell Physiol. 2010;298:C221-36 pubmed publisher
    ..We examined the interaction of the intermediate filament protein vimentin with the actin cross-linking protein filamin A in regulation of spreading in HEK-293 and 3T3 cells...
  39. Woo M, Ohta Y, Rabinovitz I, Stossel T, Blenis J. Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol Cell Biol. 2004;24:3025-35 pubmed
    ..Here we report the characterization of the cytoskeletal protein filamin A (FLNa) as a membrane-associated RSK target...
  40. Nakamura F, Stossel T, Hartwig J. The filamins: organizers of cell structure and function. Cell Adh Migr. 2011;5:160-9 pubmed
    b>Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975...
  41. D Addario M, Arora P, Ellen R, McCulloch C. Interaction of p38 and Sp1 in a mechanical force-induced, beta 1 integrin-mediated transcriptional circuit that regulates the actin-binding protein filamin-A. J Biol Chem. 2002;277:47541-50 pubmed
  42. Castoria G, D Amato L, Ciociola A, Giovannelli P, Giraldi T, Sepe L, et al. Androgen-induced cell migration: role of androgen receptor/filamin A association. PLoS ONE. 2011;6:e17218 pubmed publisher
    ..migration and observed that challenging NIH3T3 cells with 10 nM R1881 rapidly induces interaction of AR with filamin A (FlnA) at cytoskeleton. AR/FlnA complex recruits integrin beta 1, thus activating its dependent cascade...
  43. Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T, et al. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997;272:2620-8 pubmed
    ..ABP-280 participates in TNF-alpha signal transduction to SAPKs, in part through the binding of SEK-1. ..
  44. Thelin W, Chen Y, Gentzsch M, Kreda S, Sallee J, Scarlett C, et al. Direct interaction with filamins modulates the stability and plasma membrane expression of CFTR. J Clin Invest. 2007;117:364-74 pubmed
    ..In addition, we elucidate the molecular defect associated with the S13F mutation. ..
  45. Kainulainen T, Pender A, D Addario M, Feng Y, Lekic P, McCulloch C. Cell death and mechanoprotection by filamin a in connective tissues after challenge by applied tensile forces. J Biol Chem. 2002;277:21998-2009 pubmed
    ..There was a rapid (<10-s) decrease in plasma membrane potential after force application, which, in filamin A-deficient melanoma cells, contributed to irreversible cell depolarization...
  46. Beekman J, van der Poel C, van der Linden J, van den Berg D, van den Berghe P, van de Winkel J, et al. Filamin A stabilizes Fc gamma RI surface expression and prevents its lysosomal routing. J Immunol. 2008;180:3938-45 pubmed
    b>Filamin A, or actin-binding protein 280, is a ubiquitously expressed cytosolic protein that interacts with intracellular domains of multiple receptors to control their subcellular distribution, and signaling capacity...
  47. Fox J. Identification of actin-binding protein as the protein linking the membrane skeleton to glycoproteins on platelet plasma membranes. J Biol Chem. 1985;260:11970-7 pubmed
  48. Sole G, Coupry I, Rooryck C, Guerineau E, Martins F, Devés S, et al. Bilateral periventricular nodular heterotopia in France: frequency of mutations in FLNA, phenotypic heterogeneity and spectrum of mutations. J Neurol Neurosurg Psychiatry. 2009;80:1394-8 pubmed publisher
    ..Mutations in FLNA, encoding filamin A, are responsible for the X linked dominant form of BPNH (FLNA-BPNH)...
  49. Vadlamudi R, Li F, Adam L, Nguyen D, Ohta Y, Stossel T, et al. Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol. 2002;4:681-90 pubmed
    ..Here we identify filamin FLNa as a Pak1-interacting protein through a yeast two-hybrid screen using the amino terminus of Pak1 as a bait...
  50. Lin R, Karpa K, Kabbani N, Goldman Rakic P, Levenson R. Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A. Proc Natl Acad Sci U S A. 2001;98:5258-63 pubmed
    ..loop of the D2S and D3 dopamine receptors as bait to screen a human brain cDNA library, we identified filamin A (FLN-A) as a protein that interacts with both the D2 and D3 subtypes...
  51. Stahlhut M, van Deurs B. Identification of filamin as a novel ligand for caveolin-1: evidence for the organization of caveolin-1-associated membrane domains by the actin cytoskeleton. Mol Biol Cell. 2000;11:325-37 pubmed
    ..The actin network, therefore, seems to be directly involved in the spatial organization of caveolin-1-associated membrane domains. ..
  52. Fiori J, Zhu T, O Connell M, Hoek K, Indig F, Frank B, et al. Filamin A modulates kinase activation and intracellular trafficking of epidermal growth factor receptors in human melanoma cells. Endocrinology. 2009;150:2551-60 pubmed publisher
    The actin-binding protein filamin A (FLNa) affects the intracellular trafficking of various classes of receptors and has a potential role in oncogenesis...
  53. Ithychanda S, Hsu D, Li H, Yan L, Liu D, Liu D, et al. Identification and characterization of multiple similar ligand-binding repeats in filamin: implication on filamin-mediated receptor clustering and cross-talk. J Biol Chem. 2009;284:35113-21 pubmed publisher
  54. Ravid D, Chuderland D, Landsman L, Lavie Y, Reich R, Liscovitch M. Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration. Exp Cell Res. 2008;314:2762-73 pubmed publisher
    ..and mass spectrometry, that the major protein in the pp340 band is the actin filament cross-linking protein filamin A. The identity of pp340 as filamin A was confirmed by immunoprecipitation of pp340 with specific filamin A ..
  55. Berry F, O Neill M, Coca Prados M, Walter M. FOXC1 transcriptional regulatory activity is impaired by PBX1 in a filamin A-mediated manner. Mol Cell Biol. 2005;25:1415-24 pubmed
    ..Here we demonstrate that FOXC1 interacts with the actin-binding protein filamin A (FLNA)...
  56. Ohta Y, Hartwig J, Stossel T. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol. 2006;8:803-14 pubmed
    FilGAP is a newly recognized filamin A (FLNa)-binding RhoGTPase-activating protein...
  57. van Der Flier A, Sonnenberg A. Structural and functional aspects of filamins. Biochim Biophys Acta. 2001;1538:99-117 pubmed
    ..In this review aspects of filamin structure, its splice variants, binding partners and biological function will be discussed. ..
  58. Dyson J, O Malley C, Becanovic J, Munday A, Berndt M, Coghill I, et al. The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin. J Cell Biol. 2001;155:1065-79 pubmed
    ..In addition, both filamin A and B specifically interacted with SHIP-2 in this assay...
  59. Cho E, Cho D, Park J, Kurose H, Caron M, Kim K. Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor. Mol Endocrinol. 2007;21:2242-54 pubmed
    ..A continuous interaction with the actin-binding protein 280 (filamin A), which was previously known to interact with D(3)R, is required for PMA-induced D(3)R sequestration...
  60. Petrecca K, Miller D, Shrier A. Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. J Neurosci. 2000;20:8736-44 pubmed
    ..2 and the actin cytoskeleton, and that this interaction is essential for the generation of appropriate Kv4.2 current densities. ..
  61. Stossel T, Condeelis J, Cooley L, Hartwig J, Noegel A, Schleicher M, et al. Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol. 2001;2:138-45 pubmed
    ..They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins. ..
  62. Xu Y, Bismar T, Su J, Xu B, Kristiansen G, Varga Z, et al. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010;207:2421-37 pubmed publisher
    The actin cross-linking protein filamin A (FLNa) functions as a scaffolding protein and couples cell cytoskeleton to extracellular matrix and integrin receptor signaling...
  63. Minsaas L, Planaguma J, Madziva M, Krakstad B, Masià Balagué M, Katz A, et al. Filamin a binds to CCR2B and regulates its internalization. PLoS ONE. 2010;5:e12212 pubmed publisher
    ..Employing the yeast two-hybrid system, we identified the actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B...
  64. Awata H, Huang C, Handlogten M, Miller R. Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. J Biol Chem. 2001;276:34871-9 pubmed
  65. Alper O, Stetler Stevenson W, Harris L, Leitner W, Ozdemirli M, Hartmann D, et al. Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. Cancer Sci. 2009;100:1748-56 pubmed publisher
    ..Additional novel cancer biomarkers have been identified and are being developed alongside Alper-p280 for use in diagnosis of breast carcinoma and high-grade astrocytoma, and for use in the evaluation of therapeutic responses. ..
  66. Onoprishvili I, Andria M, Kramer H, Ancevska Taneva N, Hiller J, Simon E. Interaction between the mu opioid receptor and filamin A is involved in receptor regulation and trafficking. Mol Pharmacol. 2003;64:1092-100 pubmed
    The carboxyl tail of the human mu opioid receptor was shown to bind the carboxyl terminal region of human filamin A, a protein known to couple membrane proteins to actin...
  67. Klaile E, Müller M, Kannicht C, Singer B, Lucka L. CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration. J Cell Sci. 2005;118:5513-24 pubmed
    The carcinoembryonic antigen-related cell adhesion molecule CEACAM1 (CD66a) and the scaffolding protein filamin A have both been implicated in tumor cell migration...
  68. Robertson S, Jenkins Z, Morgan T, Ades L, Aftimos S, Boute O, et al. Frontometaphyseal dysplasia: mutations in FLNA and phenotypic diversity. Am J Med Genet A. 2006;140:1726-36 pubmed
    ..leading to substitutions in the actin-binding domain and within filamin repeats 9, 10, 14, 16, 22, and 23 of filamin A in 13/23 (57%) of individuals in this cohort...
  69. Tavano R, Contento R, Baranda S, Soligo M, Tuosto L, Manes S, et al. CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse. Nat Cell Biol. 2006;8:1270-6 pubmed
    ..We identified the actin-binding protein Filamin-A (FLNa) as a novel molecular partner of CD28...
  70. Wang Y, Kreisberg J, Bedolla R, Mikhailova M, deVere White R, Ghosh P. A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene. 2007;26:6061-70 pubmed
    ..This study investigates a novel role for filamin A (FlnA), a 280 kDa cytoskeletal protein (consisting of an actin-binding domain (ABD) followed by 24 sequential ..
  71. Ueda K, Ohta Y, Hosoya H. The carboxy-terminal pleckstrin homology domain of ROCK interacts with filamin-A. Biochem Biophys Res Commun. 2003;301:886-90 pubmed
    ..We also determined that the PH domain of ROCK binds to the carboxy-terminal region of filamin-A containing the last 24th repeat. ROCK co-localized with filamin-A at the protrusive cell membranes of HeLa cells. ..
  72. van der Flier A, Kuikman I, Kramer D, Geerts D, Kreft M, Takafuta T, et al. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J Cell Biol. 2002;156:361-76 pubmed
    ..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins. ..
  73. Loy C, Sim K, Yong E. Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions. Proc Natl Acad Sci U S A. 2003;100:4562-7 pubmed
    ..We have characterized a negative regulatory domain in the AR hinge region, which interacted with filamin A (FLNa), an actin-binding cytoskeletal protein...
  74. Kyndt F, Gueffet J, Probst V, Jaafar P, Legendre A, Le Bouffant F, et al. Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy. Circulation. 2007;115:40-9 pubmed
    ..5-Mb region. A standard positional cloning approach identified a P637Q mutation in the filamin A (FLNA) gene in all affected members...
  75. Bellanger J, Astier C, Sardet C, Ohta Y, Stossel T, Debant A. The Rac1- and RhoG-specific GEF domain of Trio targets filamin to remodel cytoskeletal actin. Nat Cell Biol. 2000;2:888-92 pubmed
    ..In addition, Trio GEFD1 exchange activity is not affected by filamin binding. Our results indicate that filamin, as a molecular target of Trio, may be a scaffold for the spatial organization of Rho-GTPase-mediated signalling pathways. ..
  76. Muriel O, Echarri A, Hellriegel C, Pavón D, Beccari L, Del Pozo M. Phosphorylated filamin A regulates actin-linked caveolae dynamics. J Cell Sci. 2011;124:2763-76 pubmed publisher
    ..Here, we report that filamin A is required to maintain the F-actin-dependent linear distribution of caveolin-1...
  77. Fox J, Lamperti E, Eksioglu Y, Hong S, Feng Y, Graham D, et al. Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia. Neuron. 1998;21:1315-25 pubmed
    ..We have identified the PH gene as filamin 1 (FLN1), which encodes an actin-cross-linking phosphoprotein that transduces ligand-receptor binding into actin ..
  78. Zhang W, Han S, McKeel D, Goate A, Wu J. Interaction of presenilins with the filamin family of actin-binding proteins. J Neurosci. 1998;18:914-22 pubmed
    ..These results provide a new basis for understanding the function of presenilin proteins and further implicate cytoskeletal elements in AD pathogenesis. ..
  79. Maestrini E, Patrosso C, Mancini M, Rivella S, Rocchi M, Repetto M, et al. Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7. Hum Mol Genet. 1993;2:761-6 pubmed