Gene Symbol: FLJ10261
Description: anoctamin 1
Alias: DOG1, ORAOV2, TAOS2, TMEM16A, anoctamin-1, Ca2+-activated Cl- channel, anoctamin 1, calcium activated chloride channel, calcium activated chloride channel, discovered on gastrointestinal stromal tumors protein 1, oral cancer overexpressed 2, transmembrane protein 16A (eight membrane-spanning domains), tumor-amplified and overexpressed sequence 2
Species: human
Products:     FLJ10261

Top Publications

  1. Almaca J, Tian Y, Aldehni F, Ousingsawat J, Kongsuphol P, Rock J, et al. TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A. J Biol Chem. 2009;284:28571-8 pubmed publisher
    ..We show that the Ca(2+)-activated Cl(-) channel TMEM16A together with other TMEM16 proteins are activated by cell swelling through an autocrine mechanism that involves ..
  2. Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, et al. Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling. Proc Natl Acad Sci U S A. 2013;110:E1026-34 pubmed publisher
    The calcium-activated chloride channel anoctamin 1 (ANO1) is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer, but its functional role in tumorigenesis has remained unclear...
  3. Ubby I, Bussani E, Colonna A, Stacul G, Locatelli M, Scudieri P, et al. TMEM16A alternative splicing coordination in breast cancer. Mol Cancer. 2013;12:75 pubmed publisher
    b>TMEM16A, also known as Anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors...
  4. Simon S, Grabellus F, Ferrera L, Galietta L, Schwindenhammer B, Mühlenberg T, et al. DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors. Cancer Res. 2013;73:3661-70 pubmed publisher
    ..The calcium-dependent chloride channel DOG1 (ANO1/TMEM16A), which is strongly and specifically expressed in GIST, is used as a diagnostic marker to differentiate GIST from ..
  5. Duvvuri U, Shiwarski D, Xiao D, Bertrand C, Huang X, Edinger R, et al. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res. 2012;72:3270-81 pubmed publisher
    Frequent gene amplification of the receptor-activated calcium-dependent chloride channel TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its involvement in human tumorigenesis has not been previously studied...
  6. Ruiz C, Martins J, Rudin F, Schneider S, Dietsche T, Fischer C, et al. Enhanced expression of ANO1 in head and neck squamous cell carcinoma causes cell migration and correlates with poor prognosis. PLoS ONE. 2012;7:e43265 pubmed publisher
    ..Ano1 (Dog1) is an established and sensitive marker for the diagnosis of gastrointestinal stromal tumors (GIST) and has ..
  7. Mazzone A, Bernard C, Strege P, Beyder A, Galietta L, Pasricha P, et al. Altered expression of Ano1 variants in human diabetic gastroparesis. J Biol Chem. 2011;286:13393-403 pubmed publisher
    ..Changes in Ano1 expression in ICC may directly contribute to diabetic gastroparesis. ..
  8. Ferrera L, Scudieri P, Sondo E, Caputo A, Caci E, Zegarra Moran O, et al. A minimal isoform of the TMEM16A protein associated with chloride channel activity. Biochim Biophys Acta. 2011;1808:2214-23 pubmed publisher
    b>TMEM16A protein, also known as anoctamin-1, has been recently identified as an essential component of Ca(2+)-activated Cl(-) channels. We previously reported the existence of different TMEM16A isoforms generated by alternative splicing...
  9. Chenevert J, Duvvuri U, Chiosea S, Dacic S, Cieply K, Kim J, et al. DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol. 2012;25:919-29 pubmed publisher
    Anoctamin-1 (ANO1) (DOG1, TMEM16a) is a calcium-activated chloride channel initially described in gastrointestinal stromal tumors, but now known to be expressed in a variety of normal and tumor tissues including salivary tissue in murine ..

More Information


  1. Tien J, Lee H, Minor D, Jan Y, Jan L. Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A. 2013;110:6352-7 pubmed publisher
    Transmembrane proteins with unknown function 16 (TMEM16A) is a calcium-activated chloride channel (CaCC) important for neuronal, exocrine, and smooth muscle functions...
  2. Katoh M, Katoh M. Identification and characterization of TMEM16E and TMEM16F genes in silico. Int J Oncol. 2004;24:1345-9 pubmed
    TMEM16A (FLJ10261 or ORAOV2) gene within the CCND1-FGF4-EMS1 amplicon at human chromosome 11q13.3 encodes transmembrane protein homologous to TMEM16B (C12orf3), TMEM16C (C11orf25), and TMEM16D (FLJ34272)...
  3. Tian Y, Schreiber R, Kunzelmann K. Anoctamins are a family of Ca2+-activated Cl- channels. J Cell Sci. 2012;125:4991-8 pubmed publisher
    b>Anoctamin 1 (Ano1; TMEM16A) and anoctamin 2 (Ano2; TMEM16B) are novel Cl(-) channels transiently activated by an increase in intracellular Ca(2+)...
  4. Wong N, Shelley Fraser G. Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour. Histopathology. 2010;57:250-8 pubmed publisher
    b>DOG1 and protein kinase C (PKC) theta are both sensitive immunohistochemical markers of gastrointestinal stromal tumour (GIST)...
  5. Namkung W, Phuan P, Verkman A. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J Biol Chem. 2011;286:2365-74 pubmed publisher
    b>TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC). We developed pharmacological tools to investigate the contribution of TMEM16A to CaCC conductance in human airway and intestinal epithelial cells...
  6. Yang Y, Cho H, Koo J, Tak M, Cho Y, Shim W, et al. TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature. 2008;455:1210-5 pubmed publisher
    ..Here we show that transmembrane protein 16A (TMEM16A, which we also call anoctamin 1 (ANO1)) is a bona fide Ca(2+)-activated chloride channel that is activated by intracellular Ca(2+) and Ca(2+)-..
  7. Gomez Pinilla P, Gibbons S, Bardsley M, Lorincz A, Pozo M, Pasricha P, et al. Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1370-81 pubmed publisher
    ..No other molecular marker currently exists to independently identify ICC. The expression of ANO1 (DOG1, TMEM16A), a Ca(2+)-activated Cl(-) channel, in gastrointestinal stromal tumors suggests it may be useful as an ICC marker...
  8. Tian Y, Schreiber R, Wanitchakool P, Kongsuphol P, Sousa M, Uliyakina I, et al. Control of TMEM16A by INO-4995 and other inositolphosphates. Br J Pharmacol. 2013;168:253-65 pubmed publisher
    ..Cl(-) secretion (CaCC) in airways and other tissues is due to activation of the Cl(-) channel TMEM16A (anoctamin 1)...
  9. Dutta A, Khimji A, Kresge C, Bugde A, Dougherty M, Esser V, et al. Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium. J Biol Chem. 2011;286:766-76 pubmed publisher
    ..The present studies in human, mouse, and rat BECs provide evidence that TMEM16A is the operative channel and contributes to Ca(2+)-activated Cl(-) secretion in response to extracellular ..
  10. Ríos Moreno M, Jaramillo S, Pereira Gallardo S, Vallejo A, Mora M, Garcia Escudero A, et al. Gastrointestinal stromal tumors (GISTs): CD117, DOG-1 and PKC? expression. Is there any advantage in using several markers?. Pathol Res Pract. 2012;208:74-81 pubmed publisher
    ..Expression of CD117, DOG1 and PKC? was investigated immunohistochemically in a series of 99 paraffin-embedded GISTs in order to determine the ..
  11. Hartzell H, Yu K, Xiao Q, Chien L, Qu Z. Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels. J Physiol. 2009;587:2127-39 pubmed publisher
    ..Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects. ..
  12. Hwang D, Qian X, Hornick J. DOG1 antibody is a highly sensitive and specific marker for gastrointestinal stromal tumors in cytology cell blocks. Am J Clin Pathol. 2011;135:448-53 pubmed publisher
    ..b>DOG1 has been found to be a specific and sensitive marker for GISTs on surgical material...
  13. Miettinen M, Wang Z, Lasota J. DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases. Am J Surg Pathol. 2009;33:1401-8 pubmed publisher
    ..GISTs of different sites and histologic subtypes, and 672 other tumors and normal tissues for discovered on GIST-1 (DOG1) clone K9, a newly introduced immunohistochemical marker, a chloride channel protein...
  14. Hwang S, Blair P, Britton F, O Driscoll K, Hennig G, Bayguinov Y, et al. Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles. J Physiol. 2009;587:4887-904 pubmed publisher
    ..We investigated the expression and function of a new class of CaCC, anoctamin 1 (ANO1), encoded by Tmem16a, which was discovered to be highly expressed in ICC in a microarray screen...
  15. Novelli M, Rossi S, Rodriguez Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57:259-70 pubmed publisher
    ..Immunohistochemistry with a panel of antibodies [CD117, DOG1, protein kinase C (PKC)-theta, nestin, CD34, smooth muscle actin (SMA), desmin, S100 and CD171] was performed on ..
  16. Forrest A, Joyce T, Huebner M, Ayon R, Wiwchar M, Joyce J, et al. Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol. 2012;303:C1229-43 pubmed publisher
    ..analysis revealed that the alterations in I(Cl(Ca)) were accompanied by parallel changes in the expression of TMEM16A, a gene recently shown to encode for Cl(Ca) channels...
  17. Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, Sondo E, et al. TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science. 2008;322:590-4 pubmed publisher
    ..Transfection of epithelial cells with specific small interfering RNA against each of these proteins shows that TMEM16A, a member of a family of putative plasma membrane proteins with unknown function, is associated with calcium-..
  18. Ferrera L, Caputo A, Ubby I, Bussani E, Zegarra Moran O, Ravazzolo R, et al. Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem. 2009;284:33360-8 pubmed publisher
    Expression of TMEM16A protein is associated with the activity of Ca(2+)-activated Cl(-) channels. TMEM16A primary transcript undergoes alternative splicing. thus resulting in the generation of multiple isoforms...
  19. Scudieri P, Sondo E, Ferrera L, Galietta L. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Exp Physiol. 2012;97:177-83 pubmed publisher
    ..Recently, the question of the molecular identity of CaCCs has apparently been resolved with the identification of TMEM16A protein (also known as anoctamin-1)...
  20. Ousingsawat J, Kongsuphol P, Schreiber R, Kunzelmann K. CFTR and TMEM16A are separate but functionally related Cl- channels. Cell Physiol Biochem. 2011;28:715-24 pubmed publisher
    ..Recent findings showing that TMEM16A forms the essential part of CaCC, prompted us to examine whether CFTR controls TMEM16A...
  21. Davis A, Shi J, Pritchard H, Chadha P, Leblanc N, Vasilikostas G, et al. Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01. Br J Pharmacol. 2013;168:773-84 pubmed publisher
    T16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular ..
  22. Liegl B, Hornick J, Corless C, Fletcher C. Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Am J Surg Pathol. 2009;33:437-46 pubmed publisher
    ..b>DOG1.1 is a recently described mouse monoclonal antibody reported to have superior sensitivity and specificity compared ..
  23. Perez Cornejo P, Gokhale A, Duran C, Cui Y, Xiao Q, Hartzell H, et al. Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A. 2012;109:10376-81 pubmed publisher
    The newly discovered Ca(2+)-activated Cl(-) channel (CaCC), Anoctamin 1 (Ano1 or TMEM16A), has been implicated in vital physiological functions including epithelial fluid secretion, gut motility, and smooth muscle tone...
  24. Katoh M, Katoh M. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol. 2003;22:1375-81 pubmed
    ..1) derived from the uncharacterized FLJ10261 gene. Here, we characterized the FLJ10261 gene by using bioinformatics. NM_018043...
  25. Scudieri P, Sondo E, Caci E, Ravazzolo R, Galietta L. TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels. Biochem J. 2013;452:443-55 pubmed publisher
    b>TMEM16A and TMEM16B proteins are CaCCs (Ca2+-activated Cl- channels) with eight putative transmembrane segments...
  26. Stanich J, Gibbons S, Eisenman S, Bardsley M, Rock J, Harfe B, et al. Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol. 2011;301:G1044-51 pubmed publisher
    ..These data led us to conclude that Ano1 regulates proliferation at the G(1)/S transition of the cell cycle and may play a role in tumorigenesis...
  27. Pan Y, Xu Y, Wang Z, Fang Y, Shen J. Overexpression of MexAB-OprM efflux pump in carbapenem-resistant Pseudomonas aeruginosa. Arch Microbiol. 2016;198:565-71 pubmed publisher
    ..In conclusion, overexpression of efflux pump MexAB-OprM plays an important role in carbapenem-resistant P. aeruginosa. The mutations of regulatory genes may be a main factor contributing to overexpression of MexAB-OprM. ..
  28. Dev J, Park D, Fu Q, Chen J, Ha H, Ghantous F, et al. Structural basis for membrane anchoring of HIV-1 envelope spike. Science. 2016;353:172-175 pubmed publisher
    ..These results show how a TM domain anchors, stabilizes, and modulates a viral envelope spike and suggest that its influence on Env conformation is an important consideration for HIV-1 immunogen design. ..
  29. Amelina H, Subramaniam S, Moiseeva V, Armstrong C, Pearson S, Tomita K. Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation. BMC Biol. 2015;13:37 pubmed publisher
    ..Thus, Rap1 is able to retain bouquet formation under heavily phosphorylated status. ..
  30. Rajavel M, Philip B, Buehrer B, Errede B, Levin D. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol. 1999;19:3969-76 pubmed
    ..We conclude that Hcs77 is dedicated to signaling cell wall stress during vegetative growth and that Mid2 participates in this signaling, but its primary role is in signaling wall stress during pheromone-induced morphogenesis...
  31. Leser G, Lamb R. Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane. J Virol. 2017;91: pubmed publisher
    ..HA and NA, while raft associated, reside in distinct domains, reflecting their distributions in the viral membrane. ..
  32. Bradford A, Terris J, Ecelbarger C, Klein J, Sands J, Chou C, et al. 97- and 117-kDa forms of collecting duct urea transporter UT-A1 are due to different states of glycosylation. Am J Physiol Renal Physiol. 2001;281:F133-43 pubmed
    ..We conclude that UT-A1 is a glycoprotein and that the two monomeric forms (97 and 117 kDa) in inner medullary collecting duct are the consequence of different states of glycosylation...
  33. Williamson Y, Whitmon J, West Deadwyler R, Moura H, Woolfitt A, Rees J, et al. Surfaceome Analysis Protocol for the Identification of Novel Bordetella pertussis Antigens. Methods Mol Biol. 2018;1722:3-20 pubmed publisher
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    ..The current study further supports this estimate by invalidating key results from papers that were published in Cell These findings suggest that more than 3000 publications based on APP and APP/PS overexpression must be reevaluated. ..
  35. Sampaio N, Eriksson E, Schofield L. Plasmodium falciparum PfEMP1 Modulates Monocyte/Macrophage Transcription Factor Activation and Cytokine and Chemokine Responses. Infect Immun. 2018;86: pubmed publisher
    ..Therefore, these findings describe a potential molecular basis for immune suppression by P. falciparum. ..
  36. McDonald S, Fleming K. Negative Charge Neutralization in the Loops and Turns of Outer Membrane Phospholipase A Impacts Folding Hysteresis at Neutral pH. Biochemistry. 2016;55:6133-6137 pubmed
    ..Overall, our study suggests that negative charges impact the folding hysteresis in outer membrane proteins and their neutralization may aid in protein engineering applications. ..
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    ..Taken together, our data suggest that the HpnN transporter is critical for multidrug resistance and cell wall remodeling in Burkholderia. ..
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    ..These methods are briefly reviewed in this chapter. ..
  39. Webb C, Lithgow T. Identification of BamC on the Surface of E. coli. Methods Mol Biol. 2015;1329:215-25 pubmed publisher
    ..This chapter explores the structure and topology of BamC, using a range of biochemical techniques to probe the topology and surface exposure. ..
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    ..A similar effect is also observed in plants expressing VAP27 RNAi. Taken together, these data indicate that VAP27 proteins used at EPCSs are essential for normal ER-cytoskeleton interaction and for plant development. ..
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    ..DNA entrapment and further DNase digestion assays demonstrated ability for pDNA protection by the nanoparticles against enzymatic digestion. ..
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    ..These findings provided new insights into PC therapies. Our study also supplies a new method to study other high molecular membrane proteins. ..
  43. Okahashi N, Nakata M, Kuwata H, Kawabata S. Streptococcus oralis Induces Lysosomal Impairment of Macrophages via Bacterial Hydrogen Peroxide. Infect Immun. 2016;84:2042-2050 pubmed publisher
    ..These results suggest that streptococcal H2O2 induces cell death with lysosomal destruction and then the released lysosomal cathepsins contribute to the detachment of the dead cells. ..
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    ..These results highlight the indispensable role of solid-state NMR to simultaneously determine membrane protein structures and characterize the membrane curvature in which these protein structures exist. ..
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    ..We further put forward the idea to make use of current data on phosphorylation sites of peroxisomal and peroxisome-associated proteins reported in advanced large-scale phosphoproteomic studies. ..
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    ..Our results highlight LUBAC as a novel potential therapeutic target in EBV-associated lymphoproliferative disorders. ..
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    ..The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/...
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    ..Therefore, the interaction between SelK and p97(VCP) is SelS-dependent, and the resulting ERAD complex (SelS-p97(VCP)-SelK) plays an important role in ERAD and ER stress. ..
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    ..Together, these data suggest that NCgl2760/Rv0227c plays a critical role in the elongation of the mannan backbone of mycobacterial and corynebacterial LM, further highlighting the complexity of lipoglycan pathways of Corynebacterineae. ..
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    ..In conclusion, inhibition of ATP11B expression could serve as a therapeutic strategy to overcome cisplatin resistance. ..
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    ..Recovery of Cl- via NKCC1 might have additional consequences on shaping the waveforms of slow waves via Na+ entry into microdomains. ..
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    ..We estimated that our method could predict correct folds for 1,345-1,871 reviewed human multi-pass MPs including a few hundred new folds, which shall facilitate the discovery of drugs targeting at MPs. ..
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    ..More recently, transmembrane protein with unknown function 16A (TMEM16A), hypothesized to be a candidate calcium?activated Cl? channel, has been found to be overexpressed in a number of ..
  62. Shin S, Lee D, Gil H, Kim B, Choe J, Kim J, et al. Agerarin, identified from Ageratum houstonianum, stimulates circadian CLOCK-mediated aquaporin-3 gene expression in HaCaT keratinocytes. Sci Rep. 2017;7:11175 pubmed publisher
    ..In conclusion, agerarin is a bioactive compound in AHE responsible for CLOCK-mediated AQP3 expression in keratinocytes. ..
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    ..Extension of this methodology to other disease-related or pharmacologically important membrane proteins may yield new protein biomarkers for personalized diagnostics...
  66. Lai S, Gu Z, Zhao M, Li X, Ma Y, Luo L, et al. Toxic effect of acrylamide on the development of hippocampal neurons of weaning rats. Neural Regen Res. 2017;12:1648-1654 pubmed publisher
    ..These data suggest that acrylamide exerts dose-dependent toxic effects on the growth and development of hippocampal neurons of weaning rats...
  67. Ghaedi K, Tamura S, Okumoto K, Matsuzono Y, Fujiki Y. The peroxin pex3p initiates membrane assembly in peroxisome biogenesis. Mol Biol Cell. 2000;11:2085-102 pubmed
    ..Thus, Pex3p assembles membrane vesicles before the matrix proteins are translocated. ..
  68. Akpalo H, Lange C, Zustin J. Discovered on gastrointestinal stromal tumour 1 (DOG1): a useful immunohistochemical marker for diagnosing chondroblastoma. Histopathology. 2012;60:1099-106 pubmed publisher
    ..Nine chondroblastomas were analysed using immunohistochemical antibodies [CD34, ?-smooth muscle actin (?-SMA), DOG1, CD117, AE1/AE3 and CD163]...
  69. Arbo B, Hoppe J, Rodrigues K, Garcia Segura L, Salbego C, Ribeiro M. 4'-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures. J Steroid Biochem Mol Biol. 2017;171:281-287 pubmed publisher
    ..In summary, our results show that 4'-CD is neuroprotective against A? by a mechanism involving the modulation of SOD protein expression. ..
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