Gene Symbol: FKBP2
Description: FK506 binding protein 2
Alias: FKBP-13, PPIase, peptidyl-prolyl cis-trans isomerase FKBP2, 13 kDa FK506-binding protein, 13 kDa FKBP, FK506 binding protein 2, 13kDa, FKBP-2, PPIase FKBP2, immunophilin FKBP13, proline isomerase, rapamycin-binding protein, rotamase
Species: human
Products:     FKBP2

Top Publications

  1. Jin Y, Albers M, Lane W, Bierer B, Schreiber S, Burakoff S. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. Proc Natl Acad Sci U S A. 1991;88:6677-81 pubmed
    ..The conserved residues that comprise the drug binding site and rotamase active site of FKBP-12 are completely conserved in FKBP-13...
  2. Nigam S, Jin Y, Jin M, Bush K, Bierer B, Burakoff S. Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum. Biochem J. 1993;294 ( Pt 2):511-5 pubmed
    The function of the immunophilins, FKBP 12 and FKBP 13, which are binding proteins for the immunosuppressant drug FK506 and rapamycin, remains poorly defined, although it has been suggested that immunophilins and immunophilin-like ..
  3. Walensky L, Gascard P, Fields M, Blackshaw S, Conboy J, Mohandas N, et al. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. J Cell Biol. 1998;141:143-53 pubmed
    ..1, named 4.1G, based on the interaction of its COOH-terminal domain (CTD) with the immunophilin FKBP13. The 129-amino acid peptide, designated 4.1G-CTD, is the first known physiologic binding target of FKBP13...
  4. Triplett J, Zhang Z, Sultana R, Cai J, Klein J, Büeler H, et al. Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease. J Neurochem. 2015;133:750-65 pubmed publisher
  5. Peng L, Jiang Q, Pan J, Deng C, Yu J, Wu X, et al. Involvement of polyphosphate kinase in virulence and stress tolerance of uropathogenic Proteus mirabilis. Med Microbiol Immunol. 2016;205:97-109 pubmed publisher
    ..As a whole, these results indicate that PPK is an important regulator and plays a crucial role in stress tolerance and virulence in uropathogenic P. mirabilis. ..
  6. Bezerra M, Arruda Alencar J, Martins J, Viana A, Viana Neto A, Rego J, et al. Major seminal plasma proteome of rabbits and associations with sperm quality. Theriogenology. 2019;128:156-166 pubmed publisher
    ..Moreover, finding seminal plasma proteins as indicators of semen parameters will improve assisted reproductive technologies. ..
  7. Pandya M, Liu H, Dangaria S, Zhu W, Li L, Pan S, et al. Integrative Temporo-Spatial, Mineralogic, Spectroscopic, and Proteomic Analysis of Postnatal Enamel Development in Teeth with Limited Growth. Front Physiol. 2017;8:793 pubmed publisher
    ..Together, this study provides a baseline for a comprehensive understanding of the mineralogic and proteomic events that contribute to the complexity of mammalian tooth enamel development...
  8. Keeney J, Forster S, Sultana R, Brewer L, Latimer C, Cai J, et al. Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline. Free Radic Biol Med. 2013;65:324-334 pubmed publisher
    ..Together, these results suggest that dietary VitD deficiency contributes to significant nitrosative stress in brain and may promote cognitive decline in middle-aged and elderly adults. ..
  9. Chaurasia N, Mishra Y, Chatterjee A, Rai R, Yadav S, Rai L. Overexpression of phytochelatin synthase (pcs) enhances abiotic stress tolerance by altering the proteome of transformed Anabaena sp. PCC 7120. Protoplasma. 2017;254:1715-1724 pubmed publisher
    ..Such recombinant strains have potential for future use as biofertilizer. ..

More Information

Publications109 found, 100 shown here

  1. Artier J, da Silva Zandonadi F, de Souza Carvalho F, Pauletti B, Leme A, Carnielli C, et al. Comparative proteomic analysis of Xanthomonas citri ssp. citri periplasmic proteins reveals changes in cellular envelope metabolism during in vitro pathogenicity induction. Mol Plant Pathol. 2018;19:143-157 pubmed publisher
    ..The results present new potential targets against XAC to be investigated in further functional studies...
  2. Song T, Yang M, Chen J, Huang L, Yin H, He T, et al. Prognosis of sepsis induced by cecal ligation and puncture in mice improved by anti-Clonorchis Sinensis cyclopholin a antibodies. Parasit Vectors. 2015;8:502 pubmed publisher
    ..Anti-CsCyPA antibodies could combine with MuCyPA and inhibit its peptidyl prolyl isomerase (PPIase) activity...
  3. Liu Y, Weng Y, Tsai H, Chen C, Lee D, Hsieh C, et al. Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells. Phytomedicine. 2018;46:184-192 pubmed publisher
    ..These findings indicate that PS may constitute a potential new alternative or complementary medicine for PC. ..
  4. Liu D, Zheng S, Zheng G, Lv Q, Shen B, Yuan X, et al. Adaptation of the FK506 binding protein 1B to hibernation in bats. Cryobiology. 2018;83:1-8 pubmed publisher
    ..This study provides new insights into the molecular evolution of Fkbp1b in adaptation to bat hibernation. ..
  5. Geider K, Gernold M, Jock S, Wensing A, Völksch B, Gross J, et al. Unifying bacteria from decaying wood with various ubiquitous Gibbsiella species as G. acetica sp. nov. based on nucleotide sequence similarities and their acetic acid secretion. Microbiol Res. 2015;181:93-104 pubmed publisher
    ..Gibbsiella-specific PCR primers were designed from the proline isomerase and the levansucrase genes...
  6. Harrison O, Cagampang F, Ohri S, Torrens C, Salhiyyah K, Modi A, et al. Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease. J Cardiothorac Surg. 2018;13:76 pubmed publisher
    ..Ultimately, a more affordable 'off-the-shelf' follow-on blood assay could then be developed in place of SWATH-MS, for use in the healthcare setting. ..
  7. Jia T, Wang J, Chang W, Fan X, Sui X, Song F. Proteomics Analysis of E. angustifolia Seedlings Inoculated with Arbuscular Mycorrhizal Fungi under Salt Stress. Int J Mol Sci. 2019;20: pubmed publisher
    ..Moreover, AMF enhanced the synthesis of ATP and provided sufficient energy for plant cell activity. This study implied that symbiosis of halophytes and AMF has potential as an application for the improvement of saline-alkali soils. ..
  8. Rasch J, Ünal C, Klages A, Karsli Ü, Heinsohn N, Brouwer R, et al. Peptidyl-Prolyl-cis/trans-Isomerases Mip and PpiB of Legionella pneumophila Contribute to Surface Translocation, Growth at Suboptimal Temperature, and Infection. Infect Immun. 2019;87: pubmed publisher
    ..In L. pneumophila the surface-associated PPIase Mip was shown to facilitate the establishment of the intracellular infection cycle in its early stages...
  9. Westfalewicz B, Dietrich M, Słowińska M, Judycka S, Ciereszko A. Seasonal changes in the proteome of cryopreserved bull semen supernatant. Theriogenology. 2019;126:295-302 pubmed publisher
    ..The identification of proteins connected to the variability of semen quality during the year have provided new insight into understanding the mechanisms underlying the seasonality of cattle breeding. ..
  10. Caselli A, Paoli P, Santi A, Mugnaioni C, Toti A, Camici G, et al. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme. Biochim Biophys Acta. 2016;1864:1339-55 pubmed publisher
  11. Nath P, Dong G, Braiman A, Isakov N. In vivo regulation of human CrkII by cyclophilin A and FK506-binding protein. Biochem Biophys Res Commun. 2016;470:411-416 pubmed publisher
    ..FRET-based biosensor, supporting the accumulation of cis conformers of human CrkII1-236 in the presence of PPIase inhibitors...
  12. Kumar R, Moche M, Winblad B, Pavlov P. Combined x-ray crystallography and computational modeling approach to investigate the Hsp90 C-terminal peptide binding to FKBP51. Sci Rep. 2017;7:14288 pubmed publisher
    ..It consists of two FKBP12 like active peptidyl prolyl isomerase (PPIase) domains (an active FK1 and inactive FK2 domain) and one tetratricopeptide repeat (TPR) domain that mediates ..
  13. Dhamad A, Zhou Z, Zhou J, Du Y. Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ER?) and Biochemical Characterization of the ER?-Hsp70 Interaction. PLoS ONE. 2016;11:e0160312 pubmed publisher
    ..Further studies showed that significant portions of Hsp70-1 and Hsc70 were associated with transcriptionally active chromatin and inactive chromatin, and the two Hsps interacted with ER? in both forms of the chromatins in MCF7 cells. ..
  14. Rios Covian D, Sanchez B, Martinez N, Cuesta I, Hernández Barranco A, de los Reyes Gavilan C, et al. A proteomic approach towards understanding the cross talk between Bacteroides fragilis and Bifidobacterium longum in coculture. Can J Microbiol. 2016;62:623-8 pubmed publisher
    ..This study provides mechanistic data to deepen our understanding of the interaction between Bacteroides and Bifidobacterium intestinal populations. ..
  15. Li Q, Huang Z, Gao M, Cao W, Xiao Q, Luo H, et al. Blockade of Y177 and Nuclear Translocation of Bcr-Abl Inhibits Proliferation and Promotes Apoptosis in Chronic Myeloid Leukemia Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..In summary, our study provides a new targeted therapy for the CML patients even with Tyrosine Kinase Inhibitor (TKI)-resistance. ..
  16. Company R, Antúnez O, Cosson R, Serafim A, Shillito B, Cajaraville M, et al. Protein expression profiles in Bathymodiolus azoricus exposed to cadmium. Ecotoxicol Environ Saf. 2019;171:621-630 pubmed publisher
    ..It was also demonstrated that B. azoricus was well adapted to Cd contamination therefore B. azoricus from hydrothermal vent areas may be considered a good bioindicator. ..
  17. Yi H, Xu D, Wu X, Xu F, Lin L, Zhou H. Isosteviol protects free fatty acid- and high fat diet-induced hepatic injury via modulating PKC-β/p66Shc/ROS and ER stress pathways. Antioxid Redox Signal. 2018;: pubmed publisher
    ..Conclusion: ISV prevents FFA/HFD-induced hepatic injury through modulating PKC-β/p66Shc/oxidative and ER stress pathways. ISV represents a promising therapeutic agent for NAFLD in the future. ..
  18. Iridoy M, Zubiri I, Zelaya M, Martínez L, Ausín K, Lachén Montes M, et al. Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). Int J Mol Sci. 2018;20: pubmed publisher
  19. Bonner J, Boulianne G. Diverse structures, functions and uses of FK506 binding proteins. Cell Signal. 2017;38:97-105 pubmed publisher
    ..FKBPs show peptidylprolyl cis/trans isomerase (PPIase) activity and have been shown to affect a wide range of cellular processes including protein folding, receptor ..
  20. Hu Y, Romão E, Vertommen D, Vincke C, Morales Yánez F, Gutierrez C, et al. Generation of Nanobodies against SlyD and development of tools to eliminate this bacterial contaminant from recombinant proteins. Protein Expr Purif. 2017;137:64-76 pubmed publisher
    ..Both methods allow us to prepare a recombinant protein sample where the SlyD contaminant was quantitatively eliminated. ..
  21. Cheng S, Luo M, Ding C, Peng C, Lv Z, Tong R, et al. Downregulation of Peptidylprolyl isomerase A promotes cell death and enhances doxorubicin-induced apoptosis in hepatocellular carcinoma. Gene. 2016;591:236-244 pubmed publisher
    ..In summary, our results indicate that PPIA may play a pivotal role in HCC by regulating cell growth and could serve as a novel marker and therapeutic molecular target for HCC patients. ..
  22. Du J, Hincke M, Rose Martel M, Hennequet Antier C, Brionne A, Cogburn L, et al. Identifying specific proteins involved in eggshell membrane formation using gene expression analysis and bioinformatics. BMC Genomics. 2015;16:792 pubmed publisher
  23. Krapp S, Schuy C, Greiner E, Stephan I, Alberter B, Funk C, et al. Begomoviral Movement Protein Effects in Human and Plant Cells: Towards New Potential Interaction Partners. Viruses. 2017;9: pubmed publisher
    ..Possible roles of these putative interaction partners in the begomoviral life cycle and cytoskeletal association modes are discussed. ..
  24. Ali L, Spiess M, Wobser D, Rodriguez M, Blum H, Sakιnç T. Identification and functional characterization of the putative polysaccharide biosynthesis protein (CapD) of Enterococcus faecium U0317. Infect Genet Evol. 2016;37:215-24 pubmed publisher
    ..faecium infections. ..
  25. Koch M, Mitulovic G, Hanzal E, Umek W, Seyfert S, Mohr T, et al. Urinary proteomic pattern in female stress urinary incontinence: a pilot study. Int Urogynecol J. 2016;27:1729-1734 pubmed
  26. Hassan A, Naz A, Obaid A, Paracha R, Naz K, Awan F, et al. Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets. BMC Genomics. 2016;17:732 pubmed publisher
    ..baumannii strains. The scarcity of effective antibiotics and the global expansion of sequencing data making this approach desirable in the development of effective vaccines against A. baumannii and other bacterial pathogens. ..
  27. Hanes S. Prolyl isomerases in gene transcription. Biochim Biophys Acta. 2015;1850:2017-34 pubmed publisher
    ..Members of each family of PPIase (cyclophilins, FKBPs, and parvulins) regulate gene transcription at multiple levels...
  28. Bermúdez Cruz R, Fonseca Liñán R, Grijalva Contreras L, Mendoza Hernandez G, Ortega Pierres M. Proteomic analysis and immunodetection of antigens from early developmental stages of Trichinella spiralis. Vet Parasitol. 2016;231:22-31 pubmed publisher
    ..spiralis or re-infected with this parasite, provides information that may lead to alternatives in the design of vaccines against this parasite or for modulation of immune responses. ..
  29. Dongsheng Z, Zhiguang F, Junfeng J, Zifan L, Li W. Cyclophilin A Aggravates Collagen-Induced Arthritis via Promoting Classically Activated Macrophages. Inflammation. 2017;40:1761-1772 pubmed publisher
    ..transcriptional activity of NF-?B, the pivotal transcriptional factor regulating M1 polarization, dependent of its PPIase activity...
  30. Nevers Q, Ruiz I, Ahnou N, Donati F, Brillet R, Softic L, et al. Characterization of the Anti-Hepatitis C Virus Activity of New Nonpeptidic Small-Molecule Cyclophilin Inhibitors with the Potential for Broad Anti-Flaviviridae Activity. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..studies revealed that the SMCypI bound to cyclophilin A in competition with cyclosporine (CsA), inhibited its PPIase activity, and disrupted the CypA-nonstructural protein 5A (NS5A) interaction...
  31. Zhang H, Wang J, Li S, Wang S, Liu M, Wang W, et al. Molecular cloning, expression, purification and functional characterization of an antifungal cyclophilin protein from Panax ginseng. Biomed Rep. 2017;7:527-531 pubmed publisher
    ..In addition, pgCyP showed high PPIase activity...
  32. Leung A, Jardim F, Savic N, Monneau Y, González Romero R, Gudavicius G, et al. Basic surface features of nuclear FKBPs facilitate chromatin binding. Sci Rep. 2017;7:3795 pubmed publisher
    ..discovered that consists of an N-terminal nucleoplasmin-like (NPL) domain and a C-terminal FKBP peptidyl-proline isomerase domain. Saccharomyces cerevisiae Fpr4 is one such protein...
  33. Vijayan R, Subbarao N, Manoharan N. In Silico Analysis of Conformational Changes Induced by Normal and Mutation of Macrophage Infectivity Potentiator Catalytic Residues and its Interactions with Rapamycin. Interdiscip Sci. 2015;7:326-33 pubmed publisher
    ..Mip exhibits peptidyl prolyl cis-trans isomerase (PPIase) activity, which can be inhibited by rapamycin and FK506...
  34. Ruer Laventie J, Simoni L, Schickel J, Soley A, Duval M, Knapp A, et al. Overexpression of Fkbp11, a feature of lupus B cells, leads to B cell tolerance breakdown and initiates plasma cell differentiation. Immun Inflamm Dis. 2015;3:265-79 pubmed publisher
  35. Ghartey Kwansah G, Li Z, Feng R, Wang L, Zhou X, Chen F, et al. Comparative analysis of FKBP family protein: evaluation, structure, and function in mammals and Drosophila melanogaster. BMC Dev Biol. 2018;18:7 pubmed publisher
    ..2) The known FKBPs contain FK domains, that is, a prolyl cis/trans isomerase (PPIase) domain that mediates immune suppression through inhibition of calcineurin...
  36. Storer Samaniego C, Suh J, Chattopadhyay A, Olivares K, Guy N, Sivils J, et al. The FKBP52 Cochaperone Acts in Synergy with β-Catenin to Potentiate Androgen Receptor Signaling. PLoS ONE. 2015;10:e0134015 pubmed publisher
    ..Our data suggest that co-regulation of AR by FKBP52 and β-catenin does not require FKBP52 PPIase catalytic activity, nor FKBP52 binding to Hsp90...
  37. Huang C, Hsu S. NMR assignments of the peptidyl-prolyl cis-trans isomerase domain of trigger factor from E. coli. Biomol NMR Assign. 2016;10:149-52 pubmed publisher
    ..Within the SBD, a peptidyl-prolyl cis-trans isomerase (PPIase) domain is inserted leading to an unusual domain insertion, which may provide stabilizing effect to the highly ..
  38. Dawar F, Tu J, Xiong Y, Lan J, Dong X, Liu X, et al. Chemotactic Activity of Cyclophilin A in the Skin Mucus of Yellow Catfish (Pelteobagrus fulvidraco) and Its Active Site for Chemotaxis. Int J Mol Sci. 2016;17: pubmed publisher
    ..enzymes, including cyclophilin A (CypA), a multi-functional protein with peptidyl-prolyl cis/trans isomerase (PPIase) activity. Beside various other immunological functions, CypA induces leucocytes migration in vitro in teleost...
  39. Leong K, Cheng C, Wong C, Ng I, Kwong Y, Tse E. miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression. Oncotarget. 2017;8:11343-11355 pubmed publisher
    PIN1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that regulates multiple signaling pathways to control cell fate and is found to be over-expressed in cancers, including hepatocellular carcinoma (HCC)...
  40. Liao X, Zhang A, Zheng M, Li M, Chen C, Xu H, et al. Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways. Sci Rep. 2017;7:43639 pubmed publisher
    ..signaling mechanism in cancer is proline-directed phosphorylation, which is further regulated by the unique proline isomerase Pin1...
  41. Blundell K, Pal M, Roe S, Pearl L, Prodromou C. The structure of FKBP38 in complex with the MEEVD tetratricopeptide binding-motif of Hsp90. PLoS ONE. 2017;12:e0173543 pubmed publisher
    ..In contrast FKBP8 failed to bind intact Hsp70. The PPIase domain was not essential for the interaction with Hsp90 and binding was completely encompassed by the TPR domain ..
  42. Kallscheuer N, Bott M, van Ooyen J, Polen T. Single-Domain Peptidyl-Prolyl cis/trans Isomerase FkpA from Corynebacterium glutamicum Improves the Biomass Yield at Increased Growth Temperatures. Appl Environ Microbiol. 2015;81:7839-50 pubmed publisher
    ..In C. glutamicum, a predicted single-domain FK-506 (tacrolimus) binding protein (FKBP)-type PPIase (FkpA) is encoded directly downstream of gltA, which encodes citrate synthase (CS)...
  43. Naveen V, Chu C, Chen B, Tsai Y, Hsiao C, Sun Y. Helicobacter pylori cell binding factor 2: Insights into domain motion. J Struct Biol. 2016;194:90-101 pubmed publisher
    ..HpCBF2 possesses PPIase activity and could act as a periplasmic chaperone to regulate outer membrane protein assembly...
  44. Gouiaa S, Khoudi H. Co-expression of vacuolar Na(+)/H(+) antiporter and H(+)-pyrophosphatase with an IRES-mediated dicistronic vector improves salinity tolerance and enhances potassium biofortification of tomato. Phytochemistry. 2015;117:537-46 pubmed publisher
    ..tomato plants over-expressing a Na(+)-K(+)/H(+) exchanger gene (TNHXS1), singly or with H(+)-pyrophosphatase (H(+)-PPiase) gene using a bicistronic construct...
  45. Xi W, Gong X, Yang Q, Yu H, Liou Y. Pin1At regulates PIN1 polar localization and root gravitropism. Nat Commun. 2016;7:10430 pubmed publisher
    ..Thus, Pin1At mediates the conformational dynamics of PIN1 and affects PID- and PP2A-mediated regulation of PIN1 polar localization, which correlates with the regulation of root gravitropism. ..
  46. Caporale A, Mascanzoni F, Farina B, Sturlese M, Di Sorbo G, Fattorusso R, et al. FRET-Protease-Coupled Peptidyl-Prolyl cis-trans Isomerase Assay: New Internally Quenched Fluorogenic Substrates for High-Throughput Screening. J Biomol Screen. 2016;21:701-12 pubmed publisher
    ..Due to its simplicity and precision in the determination of extent of inhibition and reaction rates required for kinetic analysis, this assay offers many advantages over other commonly used assays. ..
  47. Xi L, Wang Y, He Q, Zhang Q, Du L. Interaction between Pin1 and its natural product inhibitor epigallocatechin-3-gallate by spectroscopy and molecular dynamics simulations. Spectrochim Acta A Mol Biomol Spectrosc. 2016;169:134-43 pubmed publisher
    ..The binding model at atomic-level revealed that EGCG was bound to the Glu12, Lys13, Arg14, Met15 and Arg17 in WW domain. Furthermore, EGCG could also interact with Arg69, Asp112, Cys113 and Ser114 in PPIase domain.
  48. Bae J, Noh S, Kim K, Jang K, Park H, Chung M, et al. PIN1 in hepatocellular carcinoma is associated with TP53 gene status. Oncol Rep. 2016;36:2405-11 pubmed publisher
    ..In particular, interaction of PIN1 with mutant TP53 can act as a tumor promoter and increase its oncogenic activities in HCC. ..
  49. Romano S, Xiao Y, Nakaya M, D Angelillo A, Chang M, Jin J, et al. FKBP51 employs both scaffold and isomerase functions to promote NF-κB activation in melanoma. Nucleic Acids Res. 2015;43:6983-93 pubmed publisher
    ..Interestingly, both FKBP51 TPR and PPIase domains are required for its interaction with TRAF2 and IKKγ, whereas only the TPR domain is involved in ..
  50. Kim G, Kim J, Choi H. Peptidyl-Prolyl cis/trans Isomerase NIMA-Interacting 1 as a Therapeutic Target in Hepatocellular Carcinoma. Biol Pharm Bull. 2015;38:975-9 pubmed publisher
    ..A better understanding of the role of PIN1 in the pathogenesis of hepatocellular carcinoma may lead to the identification of molecular targets for prevention and therapeutic intervention. ..
  51. Wang J, Tochio N, Kawasaki R, Tamari Y, Xu N, Uewaki J, et al. Allosteric Breakage of the Hydrogen Bond within the Dual-Histidine Motif in the Active Site of Human Pin1 PPIase. Biochemistry. 2015;54:5242-53 pubmed publisher
    ..isomerase NIMA-interacting 1 (Pin1) is the phosphorylation-dependent cis-trans peptidyl-prolyl isomerase (PPIase) that specifically targets phosphorylated Ser/Thr-Pro motifs...
  52. Xu M, Cheung C, Chow C, Lun S, Cheung S, Lo K. Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma. PLoS ONE. 2016;11:e0156833 pubmed publisher
    ..Our findings inform the development of novel treatments targeting PIN1 for NPC patients. ..
  53. Wang X, Mahoney B, Zhang M, Zintsmaster J, Peng J. Negative Regulation of Peptidyl-Prolyl Isomerase Activity by Interdomain Contact in Human Pin1. Structure. 2015;23:2224-2233 pubmed publisher
    ..linked domains: an N-terminal WW domain for substrate binding and a larger C-terminal peptidyl-prolyl isomerase (PPIase) domain...
  54. Wang J, Feng Y, Wang C, Srinivas S, Chen C, Liao H, et al. Pathogenic Streptococcus strains employ novel escape strategy to inhibit bacteriostatic effect mediated by mammalian peptidoglycan recognition protein. Cell Microbiol. 2017;19: pubmed publisher
    ..island contains type-IV secretion system, which contains a genomic island type-IVC secretion system and a novel PPIase molecule, SP1...
  55. Cahoon L, Freitag N. Identification of Conserved and Species-Specific Functions of the Listeria monocytogenes PrsA2 Secretion Chaperone. Infect Immun. 2015;83:4028-41 pubmed publisher
  56. Pratt A, Dewage S, Pang A, Biswas T, Barnard Britson S, Cisneros G, et al. Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis. J Struct Biol. 2015;192:76-87 pubmed publisher
    ..We determined a series of crystal structures of the PPiase from Mycobacterium tuberculosis (Mtb PPiase) bound to catalytic metals, inorganic pyrophosphate (PPi; the reaction ..
  57. Tanaka Y, Amano A, Morisaki M, Sato Y, Sasaki T. Cellular peptidyl-prolyl cis/trans isomerase Pin1 facilitates replication of feline coronavirus. Antiviral Res. 2016;126:1-7 pubmed publisher
    ..Both Cyp and FKBP have peptidyl-prolyl cis-trans isomerase (PPIase) activity...
  58. Feng D, Yao J, Wang G, Li Z, Zu G, Li Y, et al. Inhibition of p66Shc-mediated mitochondrial apoptosis via targeting prolyl-isomerase Pin1 attenuates intestinal ischemia/reperfusion injury in rats. Clin Sci (Lond). 2017;131:759-773 pubmed publisher
    ..This may represent a novel prophylactic target for intestinal I/R injury. ..
  59. Kaur G, Singh S, Singh H, Chawla M, Dutta T, Kaur H, et al. Characterization of Peptidyl-Prolyl Cis-Trans Isomerase- and Calmodulin-Binding Activity of a Cytosolic Arabidopsis thaliana Cyclophilin AtCyp19-3. PLoS ONE. 2015;10:e0136692 pubmed publisher
    ..which demonstrated that this protein is enzymatically active and possesses peptidyl-prolyl cis-trans isomerase (PPIase) activity that is specifically inhibited by CsA with an inhibition constant (Ki) of 18.75 nM...
  60. Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, et al. The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci Rep. 2017;7:613 pubmed publisher
    ..inhibition of the chaperone activity of Hsp90 and Hsp70 and of the peptidyl-prolyl cis/trans isomerase (PPIase) activity of Cyps and FKBPs protected cells from intoxication with diphtheria toxin and inhibited the pH-dependent ..
  61. Chen Y, Terajima M, Banerjee P, Guo H, Liu X, Yu J, et al. FKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch. Sci Rep. 2017;7:46021 pubmed publisher
    ..Here, we postulated that peptidyl prolyl isomerase (PPIase) activity of FKBP65 positively modulates LH2 enzymatic activity and is critical for the formation of hydroxylysine-..
  62. Baker J, Shelton L, Zheng D, Favretto F, Nordhues B, Darling A, et al. Human cyclophilin 40 unravels neurotoxic amyloids. PLoS Biol. 2017;15:e2001336 pubmed publisher
    ..Here we show that cyclophilin 40 (CyP40), a PPIase, dissolves tau amyloids in vitro...
  63. Gjaltema R, van der Stoel M, Boersema M, Bank R. Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2. Proc Natl Acad Sci U S A. 2016;113:7142-7 pubmed publisher
    ..BS results from mutations in the genes coding for lysyl hydroxylase (LH) 2 or peptidyl-prolyl cis-trans isomerase (PPIase) FKBP65...
  64. Casado Vela J, Matthiesen R, Sellés S, Naranjo J. Protein-Protein Interactions: Gene Acronym Redundancies and Current Limitations Precluding Automated Data Integration. Proteomes. 2013;1:3-24 pubmed publisher
    ..Three human proteins (choline kinase, PPIase and uromodulin) and three different web-based data search engines focused on protein interaction data retrieval (..
  65. Cehofski L, Kruse A, Magnusdottir S, Alsing A, Nielsen J, Kirkeby S, et al. Dexamethasone intravitreal implant downregulates PDGFR-α and upregulates caveolin-1 in experimental branch retinal vein occlusion. Exp Eye Res. 2018;171:174-182 pubmed publisher
    ..DEX implant intervention may inhibit PDGF signaling by decreasing the retinal level of PDGFR-α while an increased content of caveolin-1 may help maintain the integrity of the blood-retinal barrier. ..
  66. Neye H, Verspohl E. The FK506 binding protein 13 kDa (FKBP13) interacts with the C-chain of complement C1q. BMC Pharmacol. 2004;4:19 pubmed publisher
  67. Haokip N, Naorem A. Functional characterisation of parvulin-type peptidyl prolyl cis-trans isomerase, PinA in Dictyostelium discoideum. Biochem Biophys Res Commun. 2017;482:208-214 pubmed publisher
    ..We conclude that PinA is required for normal growth as well as development in D. discoideum. ..
  68. Han H, Choi B, Surh Y. Dual Roles of Pin1 in Cancer Development and Progression. Curr Pharm Des. 2017;23:4422-4425 pubmed publisher
    Pin1 is a unique peptidyl-prolyl cis/trans isomerase (PPIase) that catalyzes the cis/trans isomerization of peptidyl-prolyl peptide bonds of its substrate proteins by binding to their specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) ..
  69. Wang G, Shen J, Sun J, Jiang Z, Fan J, Wang H, et al. Cyclophilin A Maintains Glioma-Initiating Cell Stemness by Regulating Wnt/?-Catenin Signaling. Clin Cancer Res. 2017;23:6640-6649 pubmed publisher
    ..Cyclophilin A (CypA) is a cytosolic protein that belongs to the peptidyl-prolyl isomerase (PPIase) family and the major intracellular target of the immunosuppressive drug cyclosporin A (CsA)...
  70. Galat A. Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities. Biomolecules. 2017;7: pubmed publisher
    ..These three attributes enhance binding of PPIase/pharmacophore complexes to diverse intracellular entities, some of which perturb signalization pathways causing ..
  71. Geitner A, Weininger U, Paulsen H, Balbach J, Kovermann M. Structure based insights into dynamics and function of two domain SlpA from Escherichia coli. Biochemistry. 2017;: pubmed publisher
    ..It forms a prominent aromatic stacking with F15, one of the key residues for PPIase activity, thus giving a possible explanation for the inherently low PPIase activity of SlpA...
  72. Liao P, Zeng S, Zhou X, Chen T, Zhou F, Cao B, et al. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding. Mol Cell. 2017;68:1134-1146.e6 pubmed publisher
    ..As a result, p53-RS interacts with c-Myc and enhances c-Myc-dependent rDNA transcription key for ribosomal biogenesis. These results unveil a CDK4-PIN1-p53-RS-c-Myc pathway as a novel mechanism for the GOF of p53-RS in HCC. ..
  73. Hendrickson B, Zhang W, Craig R, Jin Y, Bierer B, Burakoff S, et al. Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. Gene. 1993;134:271-5 pubmed
    ..FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized...
  74. Geisler M, Kolukisaoglu H, Bouchard R, Billion K, Berger J, Saal B, et al. TWISTED DWARF1, a unique plasma membrane-anchored immunophilin-like protein, interacts with Arabidopsis multidrug resistance-like transporters AtPGP1 and AtPGP19. Mol Biol Cell. 2003;14:4238-49 pubmed
    ..Heterologously expressed TWD1 does not exhibit cis-trans-peptidylprolyl isomerase (PPIase) activity and does not complement yeast FKBP12 mutants, suggesting that TWD1 acts indirectly via protein-protein ..
  75. Ernst K, Schnell L, Barth H. Host Cell Chaperones Hsp70/Hsp90 and Peptidyl-Prolyl Cis/Trans Isomerases Are Required for the Membrane Translocation of Bacterial ADP-Ribosylating Toxins. Curr Top Microbiol Immunol. 2017;406:163-198 pubmed publisher
    ..cell chaperones including Hsp90 and protein-folding helper enzymes of the peptidyl-prolyl cis/trans isomerase (PPIase) type facilitate this membrane translocation of the unfolded A-domain for ADP-ribosylating toxins but not for ..
  76. Wang L, Wang X, Ren Z, Tang W, Zou Q, Wang J, et al. Oxidative Folding of Conopeptides Modified by Conus Protein Disulfide Isomerase. Protein J. 2017;36:407-416 pubmed publisher
    ..Thus, conus protein disulfide isomerase functions not only as an enzyme that catalyses oxidative process but also a fusion partner in recombinant conotoxin expression. ..
  77. Kozlov G, Muñoz Escobar J, Castro K, Gehring K. Mapping the ER Interactome: The P Domains of Calnexin and Calreticulin as Plurivalent Adapters for Foldases and Chaperones. Structure. 2017;25:1415-1422.e3 pubmed publisher
    ..The structural diversity of the accessory factors suggests that these chaperones became specialized for glycoprotein folding through convergent evolution of their P-domain binding sites. ..
  78. Skagia A, Vezyri E, Grados K, Venieraki A, Karpusas M, Katinakis P, et al. Structure-Function Analysis of the Periplasmic Escherichia coli Cyclophilin PpiA in Relation to Biofilm Formation. J Mol Microbiol Biotechnol. 2017;27:228-236 pubmed publisher
    ..Cyclophilin PpiA, present in the periplasm of gram-negative bacteria, possesses PPIase activity but its physiological functions are still not clearly defined...
  79. Ojima Kato T, Yamamoto N, Nagai S, Shima K, Akiyama Y, Ota J, et al. Application of proteotyping Strain Solution™ ver. 2 software and theoretically calculated mass database in MALDI-TOF MS typing of Salmonella serotype. Appl Microbiol Biotechnol. 2017;101:8557-8569 pubmed publisher
    ..L17, L21, L25, and S7, Mn-cofactor-containing superoxide dismutase (SodA), peptidyl-prolyl cis-trans isomerase C (PPIase C), and protein Gns, and uncharacterized proteins YibT, YaiA, and YciF, that can allow serotyping of Salmonella...
  80. Zhu Y, Gong Y, Li A, Chen M, Kang D, Liu J, et al. Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases. Proteomics Clin Appl. 2017;: pubmed publisher
    ..pylori gene, peptidylprolyl isomerase-FK506 binding protein (PPIase-FKBP), and showed that PPIase-FKBP was capable of inducing oncogenic transformation of gastric epithelial cells...
  81. DiLella A, Hawkins A, Craig R, Schreiber S, Griffin C. Chromosomal band assignments of the genes encoding human FKBP12 and FKBP13. Biochem Biophys Res Commun. 1992;189:819-23 pubmed
    Human FKBP12 and FKBP13 are encoded by distinct genes designated FKBP1 and FKBP2, respectively. Human FKBP1 was previously characterized. The characterization of human FKBP2 is described...
  82. Arié J, Sassoon N, Betton J. Chaperone function of FkpA, a heat shock prolyl isomerase, in the periplasm of Escherichia coli. Mol Microbiol. 2001;39:199-210 pubmed
    ..Here, we show that FkpA, a heat shock periplasmic peptidyl-prolyl cis/trans isomerase (PPIase), suppresses the formation of inclusion bodies from a defective-folding variant of the maltose-binding protein, ..
  83. Padilla P, Chang M, Pacheco Rodriguez G, Adamik R, Moss J, Vaughan M. Interaction of FK506-binding protein 13 with brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1): effects of FK506. Proc Natl Acad Sci U S A. 2003;100:2322-7 pubmed
    ..These findings are consistent with a role for FKBP13 and FK506 in vesicular trafficking, influencing ARF activity through their guanine nucleotide-exchange proteins. ..
  84. Schülke J, Wochnik G, Lang Rollin I, Gassen N, Knapp R, Berning B, et al. Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors. PLoS ONE. 2010;5:e11717 pubmed publisher
    ..The differential effects of the TPR proteins on steroid receptors bear on all physiological processes related to steroid hormone activity. ..
  85. Rogals M, Greenwood A, Kwon J, Lu K, Nicholson L. Neighboring phosphoSer-Pro motifs in the undefined domain of IRAK1 impart bivalent advantage for Pin1 binding. FEBS J. 2016;283:4528-4548 pubmed publisher
    The peptidyl prolyl isomerase Pin1 has two domains that are considered to be its binding (WW) and catalytic (PPIase) domains, both of which interact with phosphorylated Ser/Thr-Pro motifs...
  86. Qiao X, Liu Y, Luo L, Chen L, Zhao C, Ai X. Effects of naturally occurring charged mutations on the structure, stability, and binding of the Pin1 WW domain. Biochem Biophys Res Commun. 2017;487:470-476 pubmed publisher
    ..Considering that the WW domain participates in the catalytic activity of the Pin1 isomerase, our study represents a novel approach for studying Pin1 function through the analysis of its naturally occurring mutants. ..
  87. Csizmok V, Montecchio M, Lin H, Tyers M, Sunnerhagen M, Forman Kay J. Multivalent Interactions with Fbw7 and Pin1 Facilitate Recognition of c-Jun by the SCFFbw7 Ubiquitin Ligase. Structure. 2018;26:28-39.e2 pubmed publisher
    ..We show that the Pin1 WW and PPIase domains interact in a dynamic complex with multiply phosphorylated c-Jun...
  88. Caraveo G, Soste M, Cappelleti V, Fanning S, van Rossum D, Whitesell L, et al. FKBP12 contributes to ?-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome. Proc Natl Acad Sci U S A. 2017;114:E11313-E11322 pubmed publisher
    ..can be inhibited with Tacrolimus through the recruitment and inhibition of the 12-kDa cis-trans proline isomerase FK506-binding protein (FKBP12)...
  89. Splinter D, Razafsky D, Schlager M, Serra Marques A, Grigoriev I, Demmers J, et al. BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012;23:4226-41 pubmed publisher
    ..Our results demonstrate that dynein recruitment to cargo requires concerted action of multiple dynein cofactors...
  90. Villmow M, Baumann M, Malesevic M, Sachs R, Hause G, Fändrich M, et al. Inhibition of A?(1-40) fibril formation by cyclophilins. Biochem J. 2016;473:1355-68 pubmed publisher
  91. Oh Y, Jeong K, Kim K, Lee Y, Jeong S, Kim S, et al. Cyclophilin B protects SH-SY5Y human neuroblastoma cells against MPP(+)-induced neurotoxicity via JNK pathway. Biochem Biophys Res Commun. 2016;478:1396-402 pubmed publisher
    ..CypB has peptidyl-prolyl cis-trans isomerase (PPIase) activity...
  92. Seufert F, Kuhn M, Hein M, Weiwad M, Vivoli M, Norville I, et al. Development, synthesis and structure-activity-relationships of inhibitors of the macrophage infectivity potentiator (Mip) proteins of Legionella pneumophila and Burkholderia pseudomallei. Bioorg Med Chem. 2016;24:5134-5147 pubmed publisher
    ..The Mip proteins of B. pseudomallei and L. pneumophila exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity and belong to the PPIase superfamily...