FKBP12

Summary

Gene Symbol: FKBP12
Description: FK506 binding protein 1A, 12kDa
Alias: FKBP-12, FKBP-1A, FKBP1, FKBP12, PKC12, PKCI2, PPIASE, 12 kDa FK506-binding protein, 12 kDa FKBP, FK506 binding protein12, FK506-binding protein 1, FK506-binding protein 12, FK506-binding protein 1A (12kD), FK506-binding protein, T-cell, 12-kD, FKBP12-Exip3, PPIase FKBP1A, immunophilin FKBP12, peptidyl-prolyl cis-trans isomerase FKBP1A, protein kinase C inhibitor 2, rotamase
Species: human

Top Publications

  1. ncbi The plasma FK506-binding protein 12 level is related to acute cellular rejection in small bowel transplantation
    K Tarumi
    Department of Laboratory Diagnosis, Sapporo Medical University School of Medicine, Japan
    Immunopharmacol Immunotoxicol 20:211-6. 1998
  2. ncbi Multimer formation by FKBP-12: roles for cysteine 23 and phenylalanine 36
    Barbara Schories
    Section of Cardiology, Department of Internal Medicine and Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    J Pept Sci 13:475-80. 2007
  3. ncbi FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury
    S F Sezen
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Int J Impot Res 14:506-12. 2002
  4. ncbi FKBP-type peptidyl-prolyl cis-trans isomerase from a sulfur-dependent hyperthermophilic archaeon, Thermococcus sp. KS-1
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 222:249-55. 1998
  5. ncbi Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum
    S K Nigam
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Biochem J 294:511-5. 1993
  6. ncbi Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins
    Anna Nilsson
    Laboratory for Biological and Medical Mass Spectrometry, Uppsala University, P O Box 583 Biomedical Centre, SE 75123 Uppsala, Sweden
    J Proteome Res 6:3952-61. 2007
  7. ncbi Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization
    Tao Xu
    Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA
    Nat Protoc 5:1831-43. 2010
  8. ncbi Non-FK506-binding protein-12 neuroimmunophilin ligands increase neurite elongation and accelerate nerve regeneration
    Bruce G Gold
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci Res 80:56-65. 2005
  9. ncbi Distribution of immunophilin FKBP-12 protein and mRNA within the mammalian cochlea and cochlear nucleus
    G Zajic
    Department of Neuroscience, Amgen Inc, Thousand Oaks, CA 91320 1789, USA
    Hear Res 159:125-31. 2001
  10. ncbi Expression of long- and short-type FK506 binding proteins in hyperthermophilic archaea
    Akira Ideno
    Marine Biotechnology Institute, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 292:57-63. 2002

Research Grants

  1. STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXES
    Jon Clardy; Fiscal Year: 1993
  2. FUNCTIONAL ANALYSIS OF ACTIVINS DURING DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2007
  3. MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASE
    Joseph Avruch; Fiscal Year: 2001
  4. Amide Acidity Analysis of Intrinsic and Ligand-induced Flexibility and Allostery
    GRISELDA HERNANDEZ; Fiscal Year: 2010
  5. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2004
  6. FKBP Interaction with RYR Calcium Channels in Heart
    Donald M Bers; Fiscal Year: 2010
  7. NOVEL PROBES FOR IMMUNOPHILIN MEDIATED CELL CONTROL
    TADEUSZ MOLINSKI; Fiscal Year: 2001
  8. Regulation of cardiac Ca2+ release channel
    Gerhard Meissner; Fiscal Year: 2006
  9. Communication between neighboring ryanodine receptor channels in skeletal muscle
    JULIO COPELLO; Fiscal Year: 2009
  10. Communication between neighboring ryanodine receptor channels in skeletal muscle
    Julio A Copello; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications166 found, 100 shown here

  1. ncbi The plasma FK506-binding protein 12 level is related to acute cellular rejection in small bowel transplantation
    K Tarumi
    Department of Laboratory Diagnosis, Sapporo Medical University School of Medicine, Japan
    Immunopharmacol Immunotoxicol 20:211-6. 1998
    Since FK506 binding protein (FKBP12) inhibits dose-dependently the immunosuppressive activity of FK506 in vitro, plasma FKBP12 levels were measured after rat small bowel transplantation (SBTx)...
  2. ncbi Multimer formation by FKBP-12: roles for cysteine 23 and phenylalanine 36
    Barbara Schories
    Section of Cardiology, Department of Internal Medicine and Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    J Pept Sci 13:475-80. 2007
    ..Additionally, FKBP-12 possesses cis-trans peptidylprolyl isomerase (rotamase) activity...
  3. ncbi FK506 binding protein 12 is expressed in rat penile innervation and upregulated after cavernous nerve injury
    S F Sezen
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Hospital, Baltimore, Maryland 21287 2411, USA
    Int J Impot Res 14:506-12. 2002
    ..function preservation after penile nerve injury, we demonstrated localizations of the immunophilin FK506 binding protein 12 (FKBP 12) in intact and injured rat penile nerves and correlated these findings with localizations of ..
  4. ncbi FKBP-type peptidyl-prolyl cis-trans isomerase from a sulfur-dependent hyperthermophilic archaeon, Thermococcus sp. KS-1
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 222:249-55. 1998
    A gene encoding an FK506 binding protein (FKBP)-type peptidyl-prolyl cis-trans isomerase (PPIase) was cloned from a hyperthermophilic archaeon, Thermococcus sp. KS-1, and sequenced...
  5. ncbi Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum
    S K Nigam
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Biochem J 294:511-5. 1993
    The function of the immunophilins, FKBP 12 and FKBP 13, which are binding proteins for the immunosuppressant drug FK506 and rapamycin, remains poorly defined, although it has been suggested that immunophilins and immunophilin-like ..
  6. ncbi Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins
    Anna Nilsson
    Laboratory for Biological and Medical Mass Spectrometry, Uppsala University, P O Box 583 Biomedical Centre, SE 75123 Uppsala, Sweden
    J Proteome Res 6:3952-61. 2007
    ..In conclusion, these data strongly suggests that FKBP-12 is altered in an experimental model of PD...
  7. ncbi Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization
    Tao Xu
    Department of Molecular, Cellular and Developmental Biology, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA
    Nat Protoc 5:1831-43. 2010
    ..One chimera consists of a FK506-binding protein (FKBP12) fused to a cellular 'address' (nuclear localization signal or nuclear export sequence)...
  8. ncbi Non-FK506-binding protein-12 neuroimmunophilin ligands increase neurite elongation and accelerate nerve regeneration
    Bruce G Gold
    Department of Neurology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci Res 80:56-65. 2005
    ..Orally active non-FKBP-12 neuroimmunophilin ligands may be useful for the treatment of human neurological disorders without any potential side effects resulting from FKBP-12 binding...
  9. ncbi Distribution of immunophilin FKBP-12 protein and mRNA within the mammalian cochlea and cochlear nucleus
    G Zajic
    Department of Neuroscience, Amgen Inc, Thousand Oaks, CA 91320 1789, USA
    Hear Res 159:125-31. 2001
    ..FKBP-12 protein and mRNA were found to be abundant throughout rat and guinea pig cochlea and DCN...
  10. ncbi Expression of long- and short-type FK506 binding proteins in hyperthermophilic archaea
    Akira Ideno
    Marine Biotechnology Institute, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 292:57-63. 2002
    ..clarify the difference between their roles in archaeal cells, they were expressed in Escherichia coli, and their PPIase and chaperone-like protein-folding activities were investigated...
  11. ncbi Adenovirus-mediated FKBP12.6 overexpression induces hypertrophy and apoptosis in cultured neonatal cardiomyocytes
    Jian Zhong
    Department of Hypertension and Endocrinology, Daping Hospital, Center for Hypertension and Metabolic Diseases, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China
    Clin Exp Pharmacol Physiol 36:135-40. 2009
    ..Previous studies have focused mainly on FKBP12.6 deficiency and so the pathophysiological consequences of FKBP12.6 overexpression remain unclear...
  12. ncbi Orthotopic liver transplantation using low-dose tacrolimus and sirolimus
    V C McAlister
    Atlantic Canada Liver Transplantation Program, Dalhousie University, Halifax, Nova Scotia, Canada
    Liver Transpl 7:701-8. 2001
    ..A low-dose combination of SRL and TAC should be compared with conventional immunosuppression in a multicenter, randomized, controlled trial...
  13. ncbi Effects of ivermectin and midecamycin on ryanodine receptors and the Ca2+-ATPase in sarcoplasmic reticulum of rabbit and rat skeletal muscle
    G P Ahern
    Muscle Research Group, John Curtin School of Medical Research, PO Box 334, Canberra, ACT 2601, Australia
    J Physiol 514:313-26. 1999
    ..sarcoplasmic reticulum (SR) of skeletal muscle are regulated by the 12 kDa FK506- (or rapamycin-) binding protein (FKBP12)...
  14. ncbi FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle
    Debbi MacMillan
    Division of Physiology and Pharmacology, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Cell Calcium 43:539-49. 2008
    ..Release may be regulated by the RyR accessory FK506-binding protein (FKBP12) either directly, as a result of FKBP12 binding to RyR, or indirectly via modulation of the activity of the ..
  15. ncbi Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer
    Razvan L Cornea
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 285:19219-26. 2010
    The 12-kDa FK506-binding proteins (FKBP12 and FKBP12.6) are regulatory subunits of ryanodine receptor (RyR) Ca(2+) release channels...
  16. ncbi Archaeal peptidyl prolyl cis-trans isomerases (PPIases) update 2004
    Tadashi Maruyama
    Japan Marine Science and Technology Center, 2 15 Natsushima cho, Yokosuka shi, Kanagawa 237 0061, Japan
    Front Biosci 9:1680-720. 2004
    ..This is a cyclosporin A (CsA) sensitive CyP with a molecular weight of 19.4 kDa. The PPIase activity and CsA sensitivity of HbsCyP19 is higher at higher salt concentration in the medium...
  17. ncbi Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor
    Manjuli Rani Sharma
    Wadsworth Center, New York State Department of Health, School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Biophys J 90:164-72. 2006
    ..6-kDa isoform of the FK506-binding protein (FKBP12.6), whereas RyR2 from other species binds both FKBP12.6 and the closely related isoform FKBP12...
  18. ncbi A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus
    B M Benton
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202
    J Cell Biol 127:623-39. 1994
    The gene (FPR3) encoding a novel type of peptidylpropyl-cis-trans-isomerase (PPIase) was isolated during a search for previously unidentified nuclear proteins in Saccharomyces cerevisiae...
  19. ncbi Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility
    J Prestle
    Department of Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany
    Circ Res 88:188-94. 2001
    The FK506-binding protein FKBP12.6 is tightly associated with the cardiac sarcoplasmic reticulum (SR) Ca(2+)-release channel (ryanodine receptor type 2 [RyR2]), but the physiological function of FKBP12.6 is unclear...
  20. ncbi Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex
    G Wiederrecht
    Department of Immunology Research, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 267:21753-60. 1992
    ..upon calmodulin (CaM) for formation of the complex and demonstrates that the peptidyl-prolyl cis-trans isomerase (PPIase) activity of FKBP12 is not required for binding of FKBP12...
  21. ncbi Localization of the 12.6-kDa FK506-binding protein (FKBP12.6) binding site to the NH2-terminal domain of the cardiac Ca2+ release channel (ryanodine receptor)
    Haruko Masumiya
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 278:3786-92. 2003
    The 12.6-kDa FK506-binding protein (FKBP12.6) interacts with the cardiac ryanodine receptor (RyR2) and modulates its channel function. However, the molecular basis of FKBP12.6-RyR2 interaction is poorly understood...
  22. ncbi Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias
    Jianmin Xiao
    Libin Cardiovascular Institute of Alberta, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, T2N 4N1, Canada
    J Biol Chem 282:34828-38. 2007
    The 12.6-kDa FK506-binding protein (FKBP12.6) is considered to be a key regulator of the cardiac ryanodine receptor (RyR2), but its precise role in RyR2 function is complex and controversial...
  23. ncbi Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein
    Spyros Zissimopoulos
    Wales Heart Research Institute, Department of Cardiology, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 282:6976-83. 2007
    ..The FK506-binding protein (FKBP) is an important regulator of channel activity, and disruption of the RyR2-FKBP12.6 association has been implicated in cardiac disease...
  24. ncbi Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes
    Xu Zhang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Cardiovasc Res 84:253-62. 2009
    ..and cardiac contractility has been functionally linked to phosphorylation-dependent dissociation of FK506 binding protein 12.6 (FKBP12.6) regulatory proteins from ryanodine receptors subtype 2 (RYR2). We used FKBP12...
  25. ncbi Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure
    M Yano
    Second Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Circulation 102:2131-6. 2000
    ..Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506-binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-induced heart failure.
  26. ncbi Interaction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domain
    Spyros Zissimopoulos
    Wales Heart Research Institute, Department of Cardiology, University of Wales College of Medicine, Cardiff CF14 4XN, UK
    J Biol Chem 280:5475-85. 2005
    ..Evidence for an interaction between RyR and FKBP is well documented, both in skeletal muscle (RyR1-FKBP12) and in cardiac muscle (RyR2-FKBP12.6), however definition of the FKBP-binding site remains elusive...
  27. ncbi FK506 binding protein from the hyperthermophilic archaeon Pyrococcus horikoshii suppresses the aggregation of proteins in Escherichia coli
    Akira Ideno
    Marine Biotechnology Institute Co, Ltd, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 000, Japan
    Appl Environ Microbiol 68:464-9. 2002
    The 29-kDa FK506 binding protein (FKBP) gene is the only peptidyl-prolyl cis-trans isomerase (PPIase) gene in the genome of Pyrococcus horikoshii...
  28. ncbi FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae
    J Heitman
    Department of Biochemistry, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 88:1948-52. 1991
    ..In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-trans isomerase). Cyclosporin A acts similarly on a different proline rotamase, cyclophilin...
  29. ncbi Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6
    Spyros Zissimopoulos
    Wales Heart Research Institute, Department of Cardiology, Wales College of Medicine, Cardiff University, UK
    Cell Biochem Biophys 43:203-19. 2005
    The immunophilin, FK506-binding protein (FKBP12), is an essential component of the ryanodine receptor channel complex of skeletal muscle (RyR1) and modulates intracellular calcium signaling from the endoplasmic reticulum...
  30. ncbi In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6
    Christopher H George
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK
    Biochem J 370:579-89. 2003
    ..The precise mode of interaction and modulation of the cardiac RyR (RyR2) channel by FKBP12/FKBP12.6 remains to be fully defined...
  31. ncbi A role for schwann cells in the neuroregenerative effects of a non-immunosuppressive fk506 derivative, jnj460
    R B Birge
    Laboratory of Molecular Oncology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuroscience 124:351-66. 2004
    ..Here we characterize a new immunophilin ligand that interacts with both FK506 binding protein 12 (FKBP12) and FKBP52, and demonstrate that JNJ460 induces neurite outgrowth from freshly explanted dorsal ..
  32. ncbi Functional identification of distinct sets of antitumor activities mediated by the FKBP gene family
    Sylvia Fong
    California Pacific Medical Research Institute, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 100:14253-8. 2003
    ..Furthermore, identifying gene regulatory networks that function to control tumor progression may permit more accurate modeling of the complex molecular mechanisms of this disease...
  33. ncbi FK506-binding protein-type peptidyl-prolyl cis-trans isomerase from a halophilic archaeum, Halobacterium cutirubrum
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, 026 0001, Iwate, Japan
    Gene 256:319-26. 2000
    ..archaeum, Halobacterium cutirubrum, has been shown to have a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase)...
  34. ncbi FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro
    M Furutani
    Kamaishi Laboratories, Marine Biotechnology Institute Co Ltd, 3 75 1 Heita Kamaishi, Iwate 026 0001, Japan
    Biochemistry 39:453-62. 2000
    ..MTFK exhibited FK506 sensitive PPIase (peptidyl prolyl cis-trans isomerase) activity which accelerated the speed of ribonuclease T1 refolding, which is ..
  35. ncbi Cyclic ADP-ribose binds to FK506-binding protein 12.6 to release Ca2+ from islet microsomes
    N Noguchi
    Department of Biochemistry, Tohoku University School of Medicine, Sendai 980 77, Miyagi, Japan
    J Biol Chem 272:3133-6. 1997
    ..cADPR as well as FK506 bound to FK506-binding protein 12.6 (FKBP12.6), which we also found occurs naturally in islet microsomes...
  36. ncbi Immunophilins in nervous system degeneration and regeneration
    M Avramut
    Department of Pathology, School of Medicine, University of Pittsburgh, S 433 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Top Med Chem 3:1376-82. 2003
    ..The latter are designated according to their molecular weight: FKBP12, 25, 52 etc. FKBP levels in the rat brain are up to 50 times higher than in the immune system...
  37. ncbi Identification of homologs for thioredoxin, peptidyl prolyl cis-trans isomerase, and glycerophosphodiester phosphodiesterase in outer membrane fractions from Treponema pallidum, the syphilis spirochete
    D V Shevchenko
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Infect Immun 65:4179-89. 1997
    ..At the same time, however, these findings also raise important issues regarding the use of OM preparations for identifying rare OM proteins of T. pallidum...
  38. ncbi Conditional transgenesis using Dimerizable Cre (DiCre)
    Nicolas Jullien
    ICNE UMR 6544 Centre National de Recherche Scientifique CNRS, Université de Méditerranée, Marseille, France
    PLoS ONE 2:e1355. 2007
    ..It is based on splitting Cre into two inactive moieties and fusing them to FKBP12 (FK506-binding protein) and FRB (binding domain of the FKBP12-rapamycin associated protein), respectively...
  39. ncbi Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein
    B Chambraud
    Institut National de la Santé et de la Recherche Médicale U488 and Collège de France, 80 rue du General Leclerc, 94276 Bicêtre Cedex, France
    Proc Natl Acad Sci U S A 96:2104-9. 1999
    ..immunophilin that, although sharing high structural and functional homologies in its amino-terminal domain with FKBP12 (FKBP1), does not have immunosuppressant activity when complexed with FK506, unlike FKBP12...
  40. ncbi Wheat FKBP73 functions in vitro as a molecular chaperone independently of its peptidyl prolyl cis-trans isomerase activity
    Isaac Kurek
    Dep artment of Plant Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Planta 215:119-26. 2002
    ..In vitro studies indicated that wFKBP73 possesses PPIase activity, binds calmodulin and forms a heterocomplex with mammalian p23 and wheat Hsp90 in wheat-germ lysate...
  41. ncbi Systemic treatment with GPI 1046 improves spatial memory and reverses cholinergic neuron atrophy in the medial septal nucleus of aged mice
    H Sauer
    Guilford Pharmaceuticals, 6611 Tributary Street, Baltimore, MD 21224, USA
    Brain Res 842:109-18. 1999
    Systemic treatment with GPI 1046, a non-immunosuppressive ligand of the immunophilin FKBP12 (FK-506-binding protein 12 kDa), has previously been shown to promote morphological recovery of the nigrostriatal dopaminergic projection after ..
  42. ncbi Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain
    S Brecht
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany
    Neuroscience 120:1037-48. 2003
    ..Following transient focal ischemia, we have analyzed the expression of FKBP12, 52 and 65 and the total FKBP enzyme activity...
  43. ncbi A novel role for the immunophilin FKBP52 in copper transport
    Reiko Sanokawa-Akakura
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Biol Chem 279:27845-8. 2004
    FK506-binding protein 52 (FKBP52) is an immunophilin that possesses peptidylprolyl cis/trans-isomerase (PPIase) activity and is a component of a subclass of steroid hormone receptor complexes...
  44. ncbi FKBP family proteins: immunophilins with versatile biological functions
    Cong Bao Kang
    School of Biological Science, Nanyang Technological University, Singapore, Singapore
    Neurosignals 16:318-25. 2008
    ..of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity...
  45. ncbi The 28.3 kDa FK506 binding protein from a thermophilic archaeum, Methanobacterium thermoautotrophicum, protects the denaturation of proteins in vitro
    A Ideno
    Marine Biotechnology Institute Co, Ltd, Kamaishi, Iwate, Japan Sekisui Chemical Co, Ltd, Minase Research Institute, Osaka, Japan
    Eur J Biochem 267:3139-49. 2000
    Two families of FK506 binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) have been found in Archaea. One is the 16-18 kDa short type FKBP family, and another is the 26-30 kDa long type FKBP family...
  46. ncbi Cryoelectron microscopy resolves FK506-binding protein sites on the skeletal muscle ryanodine receptor
    T Wagenknecht
    Wadsworth Center for Laboratories and Research, New York State Department of Health, State University of New York at Albany 12201 0509, USA
    Biophys J 70:1709-15. 1996
    A 12-kDa immunophilin (FKBP12) is an integral component of the skeletal muscle ryanodine receptor (RyR). The RyR is a hetero-oligomeric complex with structural formula (FKBP)4(Ryr1)4, where Ryr1 is the 565-kDa product of the Ryr1 gene...
  47. ncbi FK506-binding protein of the hyperthermophilic archaeum, Thermococcus sp. KS-1, a cold-shock-inducible peptidyl-prolyl cis-trans isomerase with activities to trap and refold denatured proteins
    A Ideno
    Marine Biotechnology Institute Co Ltd, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Biochem J 357:465-71. 2001
    The FK506 (tacrolimus)-binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) in the hyperthermophilic archaeum Thermococcus sp...
  48. ncbi Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria
    J U Rahfeld
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Kurt Mothes Strasse 3, D 06120 Halle Saale, Germany
    J Biol Chem 271:22130-8. 1996
    We identified a periplasmic peptidyl-prolyl cis/trans-isomerase (PPIase) of the (FK506-binding protein (FKBP) type in Escherichia coli (FK506 represents a natural peptidomacrolide containing an acylated pipecolic acid residue)...
  49. ncbi Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate
    Cahyo Budiman
    Department of Material and Life Science, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan
    FEBS J 276:4091-101. 2009
    ..SIB1 is a homodimeric protein with peptidyl prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) activity. Each monomer consists of 205 amino acid residues...
  50. ncbi The effect of FK506 on transforming growth factor beta signaling and apoptosis in chronic lymphocytic leukemia B cells
    Simona Romano
    Department of Biochemistry and Medical Biotechnologies, Federico II University, Via Pansini, 5 80131, Naples, Italy
    Haematologica 93:1039-48. 2008
    ..Recent findings of over-activation of the TGF-beta signal in FKBP12-knockout mouse prompted us to investigate whether FK506, the canonical ligand of FKBP, can activate the TGF-beta ..
  51. ncbi SUMO-conjugating enzyme (Sce) and FK506-binding protein (FKBP) encoding rice (Oryza sativa L.) genes: genome-wide analysis, expression studies and evidence for their involvement in abiotic stress response
    Neha Nigam
    Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India
    Mol Genet Genomics 279:371-83. 2008
    ..of two major stress proteins namely SUMO-conjugating enzyme (Sce) and peptidyl prolyl cis-trans isomerase (PPIase) in rice (Oryza sativa L.)...
  52. ncbi Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein
    J Ma
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    Biophys J 69:2398-404. 1995
    The cytosolic receptor for immunosuppressant drugs, FK506 binding protein (FKBP12), maintains a tight association with ryanodine receptors of sarcoplasmic reticulum (SR) membrane in skeletal muscle...
  53. ncbi FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506
    Xuehong Xu
    Herman B Wells Center for Pediatric Research, Riley Hospital for Children, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Transplantation 73:1835-8. 2002
    ..Several FKBP family members such as FKBP12, FKBP12.6, and FKBP51 are expressed in T cells...
  54. ncbi The Escherichia coli FKBP-type PPIase SlyD is required for the stabilization of the E lysis protein of bacteriophage phi X174
    Thomas G Bernhardt
    Department of Biochemistry and Biophysics, Texas A and M University, 77843 2128, USA
    Mol Microbiol 45:99-108. 2002
    ..The slyD gene encodes a FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)...
  55. ncbi Functional conservation of phosphorylation-specific prolyl isomerases in plants
    J L Yao
    Horticulture and Food Research Institute of New Zealand, Private Bag, 92169 Auckland, New Zealand
    J Biol Chem 276:13517-23. 2001
    The phosphorylation-specific peptidyl prolyl cis/trans isomerase (PPIase) Pin1 in humans and its homologues in yeast and animal species play an important role in cell cycle regulation...
  56. ncbi Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus
    Christian Löw
    Institut fur Physik, Biophysik, Martin Luther Universitat Halle Wittenberg, D 06099 Halle Saale, Germany
    J Mol Biol 398:375-90. 2010
    SlyD (sensitive to lysis D; product of the slyD gene) is a prolyl isomerase [peptidyl-prolyl cis/trans isomerase (PPIase)] of the FK506 binding protein (FKBP) type with chaperone properties...
  57. ncbi NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein
    Martin Vogtherr
    Institut für Organische Chemie der Universität Frankfurt, Marie Curie Str 11, 60439 Frankfurt, Germany
    J Mol Biol 318:1097-115. 2002
    We have solved the solution structure of the peptidyl-prolyl cis-trans isomerase (PPIase) domain of the trigger factor from Mycoplasma genitalium by homo- and heteronuclear NMR spectroscopy...
  58. ncbi Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain
    Mario D Galigniana
    Department of Pharmacology, The University of Michigan Medical School, Ann Arbor, Michigan 48109 0632, USA
    Biochemistry 41:13602-10. 2002
    ..FKBP52 has also been shown to interact either directly or indirectly via its peptidylprolyl isomerase (PPIase) domain with cytoplasmic dynein, a motor protein involved in retrograde transport of vesicles toward the nucleus...
  59. ncbi Peptidylprolyl cis/trans isomerases (immunophilins): biological diversity--targets--functions
    Andrzej Galat
    Departement d Ingenierie et d Etudes des Proteines, DSV CEA, CE Saclay, F 91191 Gif sur Yvette Cedex, France
    Curr Top Med Chem 3:1315-47. 2003
    Information recovered from genome sequencing projects, multiple sequence alignments, structural analyses of PPIase and published records were used in deciphering the biological diversity, functions and targets of four groups of proteins ..
  60. ncbi Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human cancer cells
    Brian K Law
    Department of Cancer Biology Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Mol Cell Biol 22:8184-98. 2002
    ..growth arrest could not be explained by increases in TGF-beta receptor levels or rapamycin-induced dissociation of FKBP12 from the TGF-beta type I receptor...
  61. ncbi Heart-selective expression of the chicken FK506-binding protein (FKBP) 12.6 gene during embryonic development
    Shigenobu Yazawa
    United Graduate School of Agricultural Science, Gifu University, Gifu, Japan
    Dev Dyn 226:33-41. 2003
    b>FKBP12.6, a member of the family of FK506-binding proteins, selectively associates with the cardiac isoform of the ryanodine receptor and thereby stabilizes this Ca(2+) release channel. A chicken FKBP12.6 (chFKBP12...
  62. ncbi Expression of FKBP12 in benign and malignant vascular endothelium: an immunohistochemical study on conventional sections and tissue microarrays
    John P T Higgins
    Department of Pathology, Stanford University School of Medicine, California, USA
    Am J Surg Pathol 27:58-64. 2003
    b>FKBP12 is a cytosolic FK506 binding protein that interacts with calcineurin and thereby mediates the immunosuppressive effects of FK506...
  63. ncbi Osmolyte effects on kinetics of FKBP12 C22A folding coupled with prolyl isomerization
    Andrew T Russo
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 5 154 MRB, Galveston, TX 77555 1052, USA
    J Mol Biol 330:851-66. 2003
    Unfolding and refolding kinetics of human FKBP12 C22A were monitored by fluorescence emission over a wide range of urea concentration in the presence and absence of protecting osmolytes glycerol, proline, sarcosine and trimethylamine-N-..
  64. ncbi Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells
    Aimee L Edinger
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cancer Res 63:8451-60. 2003
    ..Here, we show that the FKBP12/rapamycin complex is an essentially irreversible inhibitor of mTOR kinase activity in vitro...
  65. ncbi Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    D D Sarbassov
    Whitehead Institute for Biomedical Research, Department of Biology, Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, MA 02142, USA
    Curr Biol 14:1296-302. 2004
    ..mTOR complex contains GbetaL but not raptor and it neither regulates the mTOR effector S6K1 nor is it bound by FKBP12-rapamycin...
  66. ncbi Neointimal expression of rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics
    Gerhard Bauriedel
    Department of Internal Medicine II Cardiology, University of Bonn, Bonn, Germany
    J Vasc Res 45:173-8. 2008
    ..Therefore, we determined the presence and tem- porospatial expression pattern of FKBP12, the primary intracellular receptor of rapamycin, in rat carotid arteries after balloon injury, as well as in ..
  67. ncbi Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent
    Roger G Ptak
    Southern Research Institute, Frederick, Maryland 21701, USA
    Antimicrob Agents Chemother 52:1302-17. 2008
    ..capacity but a high inhibitory potency against cyclophilin A (CypA)-associated cis-trans prolyl isomerase (PPIase) activity...
  68. ncbi FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T
    Melanie Gerard
    Laboratory of Biomolecular Dynamics, K U Leuven, Flanders, Belgium
    J Neurochem 106:121-33. 2008
    ..In this paper, we investigated in detail the effect of FKBP12 on early aggregation and on fibril formation of wild-type, A53T and A30P alpha-SYN...
  69. ncbi Role of the Botrytis cinerea FKBP12 ortholog in pathogenic development and in sulfur regulation
    Heber Gamboa Meléndez
    Laboratoire de Génomique Fonctionnelle des Champignons Pathogènes des Plantes, UMR 5240 CNRS UCB INSA Bayer CropScience, Domaine Scientifique de la Doua, Université Lyon I, Bat Lwoff, RDC, Villeurbanne, France
    Fungal Genet Biol 46:308-20. 2009
    The functional characterization of the FKBP12 encoding gene from the phytopathogenic fungus Botrytis cinerea was carried out. B. cinerea genome sequence owns a single ortholog, named BcFKBP12, encoding a FK506-binding protein of 12kDa...
  70. ncbi Cytosolic Aryl sulfotransferase 4A1 interacts with the peptidyl prolyl cis-trans isomerase Pin1
    Deanne J Mitchell
    School of Biomedical Sciences, University of Queensland, St Lucia, QLD, Australia
    Mol Pharmacol 76:388-95. 2009
    ..These modifications may also be important for enzyme activity, which explains why specific substrates for SULT4A1 have not yet been identified...
  71. ncbi Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins
    Helena Safavi-Hemami
    Department of Biochemistry and Molecular Biology, The Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 3010 Victoria, Australia
    J Biol Chem 285:12735-46. 2010
    ..To identify whether PPIase-associated cis-trans isomerization of these residues affects the oxidative folding of conotoxins, we identified, ..
  72. ncbi Molecular consequences of the ACVR1(R206H) mutation of fibrodysplasia ossificans progressiva
    Gin Ah Song
    Department of Molecular Genetics, BK21 Program, School of Dentistry and Dental Research Institute, Seoul National University, Seoul 110 749, Korea
    J Biol Chem 285:22542-53. 2010
    ..The R206H mutant showed a decreased binding affinity for FKBP1A/FKBP12, a known safeguard molecule against the leakage of transforming growth factor (TGF)-beta or BMP signaling...
  73. ncbi Cyclophilin A is involved in functional expression of the Na(+)-Ca(2+) exchanger NCX1
    Benayahu Elbaz
    Department of Biochemistry and Molecular Biology, Hebrew University Hadassah Medical School, P O Box 12272, Jerusalem 91120, Israel
    Biochemistry 49:7634-42. 2010
    ..make up a class of proteins that are involved in protein folding via their peptidyl prolyl cis-trans isomerase (PPIase) and chaperone domains. They are also the cellular receptors of cyclosporin A (CsA)...
  74. ncbi Multi-timescale dynamics study of FKBP12 along the rapamycin-mTOR binding coordinate
    Paul J Sapienza
    Division of Medicinal Chemistry and Natural Products, University of North Carolina, Chapel Hill, NC 27599, USA
    J Mol Biol 405:378-94. 2011
    ..FKBP12 (FK506 binding protein 12) is a prolyl cis-trans isomerase and a drug target...
  75. ncbi Sildenafil and FDP-Sr attenuate diabetic cardiomyopathy by suppressing abnormal expression of myocardial CASQ2, FKBP12.6, and SERCA2a in rats
    Yu Si Cheng
    The Faculty of Pharmacy, China Pharmaceutical University, Nanjing, China
    Acta Pharmacol Sin 32:441-8. 2011
    To study whether calcium-modulating proteins CASQ2, FKBP12.6 and SERCA2a participate in diabetic cardiomyopathy, and whether the beneficial actions of testosterone, sildenafil or fructose diphosphate Sr (FDP-Sr) in the treatment of ..
  76. ncbi Down-regulation of FKBP12.6 and SERCA2a contributes to acute heart failure in septic shock and is related to an up-regulated endothelin signalling pathway
    Hai Bo He
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China
    J Pharm Pharmacol 59:977-84. 2007
    ..It is hypothesized that AHF is linked to down-regulation of FKBP12.6 (calstabin 2) and SERCA2a (sarco/endoplasmic reticulum Ca2+ ATPase 2a), which may be mediated by an activated ..
  77. ncbi Saccharomyces cerevisiae FKBP12 binds Arabidopsis thaliana TOR and its expression in plants leads to rapamycin susceptibility
    Rodnay Sormani
    DSV DEVM Laboratoire de Génétique et de Biophysique des Plantes, UMR 6191 CNRS CEA Université de la Méditerranée, Faculte des Sciences de Luminy, Marseille France
    BMC Plant Biol 7:26. 2007
    ..be inactivated by the antibiotic rapamycin following the formation of a ternary complex between TOR, rapamycin and FKBP12 proteins. The TOR protein is also found in higher plants despite the fact that they are rapamycin insensitive...
  78. ncbi An assay for the determination of sirolimus levels in the lymphocyte of transplant patients
    M Masri
    Transmedical Research Institute, Beirut, Lebanon
    Transplant Proc 39:1204-6. 2007
    Both tacrolimus (TAC) and sirolimus (SRL) bind to the same immunophilin FKBP12; however, their mechanisms of action are distinct. SRL inhibits mammalian target of rapamycin (TOR), which is an enzyme critical to the immune function...
  79. ncbi Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
    Kathryn E Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:12288-93. 2004
    ....
  80. ncbi Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency
    Wei Tang
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    FASEB J 18:1597-9. 2004
    The immunophilin FKBP12 binds the skeletal muscle Ca2+ release channel or ryanodine receptor (RyR1), but the functional consequences of this interaction are not known...
  81. ncbi The crystal structure of ribosomal chaperone trigger factor from Vibrio cholerae
    Anthony V Ludlam
    Department of Biological Chemistry, Medical School and Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 101:13436-41. 2004
    ..The chaperone has a peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the rate-limiting proline isomerization in the protein-folding process...
  82. ncbi FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation
    Miguel Arevalo-Rodriguez
    Department of Molecular Genetics and Microbiology, Box 3546, 322 CARL Building, Research Dr, Duke University Medical Center, Durham, NC 27710, USA
    Eukaryot Cell 3:1287-96. 2004
    b>FKBP12 is a conserved member of the prolyl-isomerase enzyme family and serves as the intracellular receptor for FK506 that mediates immunosuppression in mammals and antimicrobial actions in fungi...
  83. ncbi The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner
    Chaitali Basak
    Department of Chemistry, Bose Institute, Kolkata, India
    J Immunol 174:5672-80. 2005
    ....
  84. ncbi Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells
    Sven Eyckerman
    Flanders Interuniversity Institute for Biotechnology, VIB09, Department of Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, A Baertsoenkaai 3, B 9000 Ghent, Belgium
    Nat Methods 2:427-33. 2005
    ..protein-protein interaction trap (MAPPIT) screens were developed to monitor interactions between the erythropoietin receptor (EpoR) and suppressors of cytokine signaling (SOCS) proteins, between FKBP12 and ALK4, and between MDM2 and p53.
  85. ncbi Effects of FK506 on ca release channels (review)
    Terutaka Ozawa
    Department of Physiology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Perspect Medicin Chem 2:51-5. 2008
    ..In T-lymphocytes, FK506 binds to the intracellular receptor, a 12-kDa FK506-binding protein (FKBP12). The FK506-FKBP12 complex binds to the phosphatase calcineurin (CN) and inhibits the activity of CN...
  86. ncbi Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii
    Jose L Crespo
    Instituto de Bioquimica Vegetal y Fotosintesis, Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, Centro de Investigaciones Cientificas Isla de la Cartuja, 41092 Seville, Spain
    Plant Physiol 139:1736-49. 2005
    The macrolide rapamycin specifically binds the 12-kD FK506-binding protein (FKBP12), and this complex potently inhibits the target of rapamycin (TOR) kinase...
  87. ncbi A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats
    Min You Qi
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China
    J Cardiovasc Pharmacol 47:729-35. 2006
    ..However, an implication of a down-regulation of FK506-binding protein or calstabin-2 (FKBP12.6) is undefined. It was hypothesized that the down-regulation of FKBP12...
  88. ncbi Abrupt changes in FKBP12.6 and SERCA2a expression contribute to sudden occurrence of ventricular fibrillation on reperfusion and are prevented by CPU86017
    Tao Na
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, China
    Acta Pharmacol Sin 28:773-82. 2007
    ..We aimed to study whether changes in the expression of FKBP12.6 and SERCA2a and the endothelin (ET) system on reperfusion against ischemia were related to the rapid occurrence ..
  89. ncbi Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis
    Yusuke Nakatsu
    From the Department of Medical Science, Graduate School of Medicine, University of Hiroshima, 1 2 3 Kasumi, Minami Ku, Hiroshima City, Hiroshima 734 8553, Japan
    J Biol Chem 286:20812-22. 2011
    ..Taken together, these observations indicate that Pin1 binds to IRS-1 and thereby markedly enhances insulin action, essential for adipogenesis...
  90. ncbi Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin
    C P Connern
    Department of Biochemistry, School of Medical Sciences, University of Bristol, U K
    Biochem J 284:381-5. 1992
    1. Rat liver mitochondrial matrix peptidyl-prolyl cis-trans-isomerase (PPIase) has been purified. The major form of the enzyme has a molecular mass of 18.6 kDa, with a minor active component of 17.6 kDa. 2...
  91. ncbi Genomic characterization of the human peptidyl-prolyl-cis-trans-isomerase, mitochondrial precursor gene: assessment of its role in familial dilated cardiomyopathy
    K R Bowles
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    Hum Genet 105:582-6. 1999
    ..DNA analysis of the entire PPIF coding region (including the intron-exon boundaries) of two affected and one unaffected family member revealed no mutations, therefore excluding this gene as the cause of FDCM in this family...
  92. ncbi Oxygen stress increases prolyl cis/trans isomerase activity and expression of cyclophilin 18 in rabbit blastocysts
    A N Santos
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, D 06097 Halle Saale, Germany
    Biol Reprod 62:1-7. 2000
    The peptidyl-prolyl cis/trans isomerase (PPIase) activity and the expression of cyclophilins were studied in 6-day-old rabbit preimplantation embryos cultured under physiological and increased oxygen concentrations of 5% and 20% O(2), ..
  93. ncbi An inositolphosphate-binding immunophilin, IPBP12
    E B Cunningham
    Department of Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark, NJ 07103 2714, USA
    Blood 94:2778-89. 1999
    ..However, unlike the cytosolic FKBP12, the isomerase activity of this membrane-associated immunophilin is strongly inhibited by nanomolar concentrations ..
  94. ncbi Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    J Choi
    Department of Chemistry, Baker Laboratory, Cornell University, Ithaca, NY 14853 1301, USA
    Science 273:239-42. 1996
    Rapamycin, a potent immunosuppressive agent, binds two proteins: the FK506-binding protein (FKBP12) and the FKBP-rapamycin-associated protein (FRAP)...
  95. ncbi Immunophilin FK506-binding protein 52 (not FK506-binding protein 12) mediates the neurotrophic action of FK506
    B G Gold
    Center for Research on Occupational and Environmental Toxicology, Oregon Health Sciences University, Portland, Oregon
    J Pharmacol Exp Ther 289:1202-10. 1999
    ..Components of steroid receptor complexes represent novel targets for the rational design of new neurotrophic drugs...
  96. ncbi Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase
    K J Dolinski
    Department of Genetics, Pharmacology and Cancer Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 151:935-44. 1999
    The immunosuppressive drugs FK506 and rapamycin bind to the cellular protein FKBP12, and the resulting FKBP12-drug complexes inhibit signal transduction...
  97. ncbi Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture
    R L Brooksbank
    Department of Physiology, University of the Witwatersrand Medical School, Parktown, Johannesburg, South Africa
    Anesthesiology 89:693-8. 1998
    b>FKBP12 is a protein that is closely associated with the ryanodine receptor type 1 of skeletal muscle and modulates Ca2+ release by the channel...
  98. ncbi FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain
    A M Cameron
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:27582-8. 1997
    The immunophilin FKBP12 is one of the most abundant and conserved proteins in biology...
  99. ncbi The human PIN1 peptidyl-prolyl cis/trans isomerase gene maps to human chromosome 19p13 and the closely related PIN1L gene to 1p31
    H D Campbell
    Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia
    Genomics 44:157-62. 1997
    ..The protein encoded by PIN1L may have some functional role or alternatively PIN1L may be a transcribed pseudogene...
  100. ncbi FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity
    M E Cardenas
    Department of Genetics, Durham, NC 27710, USA
    EMBO J 14:5892-907. 1995
    In complex with the immunophilin FKBP12, the natural product rapamycin inhibits signal transduction events required for G1 to S phase cell cycle progression in yeast and mammalian cells...
  101. ncbi An 11.8 kDa proteolytic fragment of the E. coli trigger factor represents the domain carrying the peptidyl-prolyl cis/trans isomerase activity
    G Stoller
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle S, Germany
    FEBS Lett 384:117-22. 1996
    The 48 kDa trigger factor (TF) of E. coli was shown to be a peptidyl-prolyl cis/trans isomerase (PPIase). Its location on a ribosomal particle is unique among the PPIases described so far, and suggests a role in de novo protein folding...

Research Grants90

  1. STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXES
    Jon Clardy; Fiscal Year: 1993
    ..The structures of the complexes would be important for basic science and would provide much needed information on the pathway of cytoplasmic signal transduction...
  2. FUNCTIONAL ANALYSIS OF ACTIVINS DURING DEVELOPMENT
    Martin Matzuk; Fiscal Year: 2007
    ..an activin binding protein (follistatin), activin receptor type II, a downstream receptor binding protein (FKBP 12), and SMADS...
  3. MOLECULAR BASIS OF CELL GROWTH CONTROL BY THE TOR KINASE
    Joseph Avruch; Fiscal Year: 2001
    ..These studies will define a new signal transduction pathway controlling cell growth in lymphoid and other cells. ..
  4. Amide Acidity Analysis of Intrinsic and Ligand-induced Flexibility and Allostery
    GRISELDA HERNANDEZ; Fiscal Year: 2010
    ..Our studies develop a novel approach to characterizing these motions within the pharmaceutical targets FKBP12 and the PDZ domains of syntenin which play central roles in acute heart failure and melanoma metastasis, ..
  5. FRAP AND THE RAPAMYCIN SENSITIVE SIGNALING PATHWAY
    Jie Chen; Fiscal Year: 2004
    ..A working hypothesis for the current research is that the human protein FRAP (FKBP 12-rapamycin-associated protein), a member of the recently discovered family of phosphatidylinositol kinase (PIK)-..
  6. FKBP Interaction with RYR Calcium Channels in Heart
    Donald M Bers; Fiscal Year: 2010
    ..b>FKBP12 and FKBP12.6 are small proteins that bind tightly with RyR1 and RyR2, respectively...
  7. NOVEL PROBES FOR IMMUNOPHILIN MEDIATED CELL CONTROL
    TADEUSZ MOLINSKI; Fiscal Year: 2001
    ..b>FKBP12 is a protein physically associated with the ryanodine receptor that affects Ca2+ transport across SR/ER...
  8. Regulation of cardiac Ca2+ release channel
    Gerhard Meissner; Fiscal Year: 2006
    ..6 kDa FK506 binding protein (FKBP12.6) subunits...
  9. Communication between neighboring ryanodine receptor channels in skeletal muscle
    JULIO COPELLO; Fiscal Year: 2009
    ..aim is subdivided in three sub-Aims: A) Define the role of ATP/Mg2+ in RyR1 coordination; B) Define the role of Ca2+ in coordinated gating; and C) Define the role of FKBP12 (Calstabilinl) and other ancillary proteins.
  10. Communication between neighboring ryanodine receptor channels in skeletal muscle
    Julio A Copello; Fiscal Year: 2010
    ..This aim is subdivided in three sub-Aims: A) Define the role of ATP/Mg2+ in RyR1 coordination;B) Define the role of Ca2+ in coordinated gating;and C) Define the role of FKBP12 (Calstabilinl) and other ancillary proteins.
  11. MODULATION OF SARCOPLASMIC RETICULUM CALCIUM RELEASE
    SUSAN L contact HAMILTON; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): FKBP12 is a small immunophilin that binds with high affinity to sarcoplasmic reticulum Ca2+ release channels (ryanodine receptors, RyRs) and transforming growth factor 21 receptors (T2I RI)...
  12. MODULATION OF SARCOPLASMIC RETICULUM CALCIUM RELEASE
    Susan Hamilton; Fiscal Year: 2009
    b>FKBP12 is a small immunophilin that binds with high affinity to sarcoplasmic reticulum Ca2+ release channels (ryanodine receptors, RyRs) and transforming growth factor 21 receptors (T2I RI)...
  13. STRUCTURES OF IMMUNOPHILINS AND THEIR COMPLEXES
    Jon Clardy; Fiscal Year: 1999
    ..Specific aims towards this goal include: 1) Structures of FKBP12 complexes that define the binding and effector regions of FK506-like materials and the effector region of ..
  14. IMMUNOSUPPRESSANT TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 1999
    ..in which the drugs diffuse into the cell, associate with an immunophilin protein, cyclophilin A for CsA and FKBP12 for FK506/rapamycin, and are toxic to other proteins...
  15. G PROTEINS AND OPIOID RECEPTOR FUNCTIONS
    Ping Yee Law; Fiscal Year: 2007
    ..g., the FK506 binding protein FKBP12 that interacted specifically with the carboxyl tail domains of MOR (mu-opioid receptor)...
  16. QUADRUPOLE TIME OF FLIGHT MASS SPECTROMETER
    Gary Nelsestuen; Fiscal Year: 2001
    ..Telomeres," "Molecular biology of mosquitoes," "Cytoskeleton- based transport within the cell," "Study of FK506 Binding Protein 12 (FKBP12) in muscle," "Vitamin K-dependent proteins. Porins of pathogenic E...
  17. NOVEL ANTIFUNGAL DRUG TARGETS IN CRYPTOCOCCUS NEOFORMANS
    Joseph Heitman; Fiscal Year: 2005
    ..In studies supported by this award, we have identified the fungal drug target proteins, including FKBP12, the Tor1 kinase, and two cyclophilin A homologs...
  18. STRUCTURAL ANALYSIS OF THE CA++ RELEASE CHANNEL
    Susan Hamilton; Fiscal Year: 1999
    ..showing the images of closed and open Ca-release channels and Ca-release channels treated with rapamycin to remove FKBP12. Extensive biochemical evidence is also presented for peptide mapping and immunochemical identification and ..
  19. CARDIAC AND SKELETAL MUSCLE CALCIUM RELEASE CHANNELS
    Andrew Marks; Fiscal Year: 2006
    ..of identifying functional domains of the channels and in understanding the role of the FK506 binding protein (FKBP12/12.6) in regulating RyR function. Significant new findings and preliminary data include: 1) FKBP12/12...
  20. THE ROLE OF PIN1 IN MITOSIS WITH DESIGNED INHIBITORS
    FELICIA ETZKORN; Fiscal Year: 2002
    ..the folding process is accelerated by the peptidyl-prolyl isomerase (PPIase enzymes)...
  21. ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITING
    Joseph Heitman; Fiscal Year: 2005
    ..we have identified fungal homologs of the mammalian target proteins calcineurin A, calcineurin B, cyclophilin A, FKBP12, TOR1, and TOR2...
  22. Bone Morphogenic Protein Signaling Pathways in Uterine Biology
    Martin M Matzuk; Fiscal Year: 2010
    ..with mutations in activin subunits, a ligand binding protein (follistatin), a downstream receptor-binding protein (FKBP12), several SMADs, and multiple BMP/activin/myostatin receptors...