fibronectin

Summary

Gene Symbol: fibronectin
Description: fibronectin 1
Alias: CIG, ED-B, FINC, FNZ, GFND, GFND2, LETS, MSF, SMDCF, fibronectin, cold-insoluble globulin, migration-stimulating factor
Species: human
Products:     fibronectin

Top Publications

  1. Zardi L, Carnemolla B, Siri A, Petersen T, Paolella G, Sebastio G, et al. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon. EMBO J. 1987;6:2337-42 pubmed
    Purification and amino acid sequence analysis of a proteolytic fragment of fibronectin (FN) from transformed human cells demonstrated that a high percentage of these FN molecules contains an extra amino acid sequence which is present ..
  2. Gutman A, Kornblihtt A. Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA. Proc Natl Acad Sci U S A. 1987;84:7179-82 pubmed
    We describe here a third region of variability in human fibronectin (FN) due to alternative RNA splicing. Two other positions of alternative splicing have been reported previously (ED and IIICS)...
  3. Garcia Pardo A, Rostagno A, Frangione B. Primary structure of human plasma fibronectin. Characterization of a 38 kDa domain containing the C-terminal heparin-binding site (Hep III site) and a region of molecular heterogeneity. Biochem J. 1987;241:923-8 pubmed
    The primary structure of a 38 kDa heparin-binding domain from human plasma fibronectin has been determined. This domain contains 380 residues arranged in three type-III homology regions of approx...
  4. Williams M, Phan I, Harvey T, Rostagno A, Gold L, Campbell I. Solution structure of a pair of fibronectin type 1 modules with fibrin binding activity. J Mol Biol. 1994;235:1302-11 pubmed
    The tertiary structure of the fourth and fifth type 1 module pair from the N terminus of human fibronectin, has been determined by two-dimensional homonuclear 1H nuclear magnetic resonance (NMR) spectroscopy...
  5. Leahy D, Aukhil I, Erickson H. 2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell. 1996;84:155-64 pubmed
    We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10)...
  6. Wann E, Gurusiddappa S, Hook M. The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen. J Biol Chem. 2000;275:13863-71 pubmed
    ..that mediate the adherence of the bacteria to host extracellular matrix components, such as collagen, fibronectin (Fn), and fibrinogen (Fg). Two Fn-binding MSCRAMMs, FnbpA and FnbpB, have been previously identified...
  7. Rybak J, Roesli C, Kaspar M, Villa A, Neri D. The extra-domain A of fibronectin is a vascular marker of solid tumors and metastases. Cancer Res. 2007;67:10948-57 pubmed
    ..In particular, we found that the alternatively spliced extra-domain A (EDA) of fibronectin is strongly expressed in the neovasculature of liver metastases, while being undetectable in most normal organs...
  8. Erat M, Slatter D, Lowe E, Millard C, Farndale R, Campbell I, et al. Identification and structural analysis of type I collagen sites in complex with fibronectin fragments. Proc Natl Acad Sci U S A. 2009;106:4195-200 pubmed publisher
    Collagen and fibronectin are major components of vertebrate extracellular matrices...
  9. Nakata K, Ujike H, Sakai A, Takaki M, Imamura T, Tanaka Y, et al. Association study between the fibronectin gene and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003;116B:41-4 pubmed
    b>Fibronectin is one of the cell adhesion proteins...

More Information

Publications75

  1. Norris N, Bingham R, Harris G, Speakman A, Jones R, Leech A, et al. Structural and functional analysis of the tandem ?-zipper interaction of a Streptococcal protein with human fibronectin. J Biol Chem. 2011;286:38311-20 pubmed publisher
    Bacterial fibronectin-binding proteins (FnBPs) contain a large intrinsically disordered region (IDR) that mediates adhesion of bacteria to host tissues, and invasion of host cells, through binding to fibronectin (Fn)...
  2. Lin Y, Greenwood A, Nicholson L, Sharma Y, McDonough S, Chang Y. Fibronectin binds to and induces conformational change in a disordered region of leptospiral immunoglobulin-like protein B. J Biol Chem. 2009;284:23547-57 pubmed publisher
    ..protein B) contributes to the binding of Leptospira to extracellular matrix proteins such as fibronectin (Fn), fibrinogen, laminin, and collagen...
  3. Caicedo Carvajal C, Shinbrot T, Foty R. Alpha5beta1 integrin-fibronectin interactions specify liquid to solid phase transition of 3D cellular aggregates. PLoS ONE. 2010;5:e11830 pubmed publisher
    ..Integrin alpha5beta1 and soluble fibronectin (sFN) are key players in cell-ECM force generation and in ECM polymerization...
  4. Giannini R, Faviana P, Cavinato T, Elisei R, Pacini F, Berti P, et al. Galectin-3 and oncofetal-fibronectin expression in thyroid neoplasia as assessed by reverse transcription-polymerase chain reaction and immunochemistry in cytologic and pathologic specimens. Thyroid. 2003;13:765-70 pubmed
    Oncofetal fibronectin (onfFN) and galectin-3 (Gale-3) have been proposed as possible tools for the preoperative diagnosis of thyroid carcinomas, based on the finding that the expression of both onfFN and Gale-3 are significantly ..
  5. Kenny H, Kaur S, Coussens L, Lengyel E. The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin. J Clin Invest. 2008;118:1367-79 pubmed publisher
    ..MMP-2 enhanced peritoneal adhesion of OvCa cells through cleavage of ECM proteins fibronectin (FN) and vitronectin (Vn) into small fragments and increased binding of OvCa cells to these FN and Vn fragments ..
  6. Cho J, Mosher D. Role of fibronectin assembly in platelet thrombus formation. J Thromb Haemost. 2006;4:1461-9 pubmed
    b>Fibronectin is a component of subendothelial matrices and abundant in plasma. A role of fibronectin in thrombogenesis has been suspected for three decades...
  7. Kay R, Ellis I, Jones S, Perrier S, Florence M, Schor A, et al. The expression of migration stimulating factor, a potent oncofetal cytokine, is uniquely controlled by 3'-untranslated region-dependent nuclear sequestration of its precursor messenger RNA. Cancer Res. 2005;65:10742-9 pubmed
    b>Migration stimulating factor (MSF) is a truncated oncofetal fibronectin isoform expressed by fetal and tumor-associated cells. MSF mRNA is distinguished from other fibronectin isoforms by its size (2...
  8. Siemianowicz K, Gminski J, Francuz T, Syzdol M, Polanska D, Machalski M, et al. Fibronectin gene polymorphism in patients with lung cancer. Oncol Rep. 2001;8:1289-92 pubmed
    b>Fibronectin (FN) is a glycoprotein component of connective tissue. It is involved in cancer progression. FN plays a role in non-neoplasmatic lung pathology in which fibronectin gene polymorphisms (RFLPs) have been studied...
  9. Ding Y, Gelfenbeyn K, Freire de Lima L, Handa K, Hakomori S. Induction of epithelial-mesenchymal transition with O-glycosylated oncofetal fibronectin. FEBS Lett. 2012;586:1813-20 pubmed publisher
    ..We previously found that fibronectin (FN) carrying O-GalNAc at a specific site is selectively expressed in cancer and fetal cells/tissues, and ..
  10. Katagiri Y, Brew S, Ingham K. All six modules of the gelatin-binding domain of fibronectin are required for full affinity. J Biol Chem. 2003;278:11897-902 pubmed
    The gelatin-binding sites of fibronectin are confined to a 42-kDa region having four type I and two type II modules in the following order: I(6)-II(1)-II(2)-I(7)-I(8)-I(9)...
  11. Schwarz Linek U, Werner J, Pickford A, Gurusiddappa S, Kim J, Pilka E, et al. Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper. Nature. 2003;423:177-81 pubmed
    Staphylococcus aureus and Streptococcus pyogenes, two important human pathogens, target host fibronectin (Fn) in their adhesion to and invasion of host cells...
  12. Bingham R, Rudiño Piñera E, Meenan N, Schwarz Linek U, Turkenburg J, Hook M, et al. Crystal structures of fibronectin-binding sites from Staphylococcus aureus FnBPA in complex with fibronectin domains. Proc Natl Acad Sci U S A. 2008;105:12254-8 pubmed publisher
    Staphylococcus aureus can adhere to and invade endothelial cells by binding to the human protein fibronectin (Fn). FnBPA and FnBPB, cell wall-attached proteins from S...
  13. Smith M, Gourdon D, Little W, Kubow K, Eguiluz R, Luna Morris S, et al. Force-induced unfolding of fibronectin in the extracellular matrix of living cells. PLoS Biol. 2007;5:e268 pubmed
    Whether mechanically unfolded fibronectin (Fn) is present within native extracellular matrix fibrils is controversial...
  14. Kim J, Singvall J, Schwarz Linek U, Johnson B, Potts J, Hook M. BBK32, a fibronectin binding MSCRAMM from Borrelia burgdorferi, contains a disordered region that undergoes a conformational change on ligand binding. J Biol Chem. 2004;279:41706-14 pubmed
    BBK32 is a fibronectin-binding lipoprotein on Borrelia burgdorferi, the causative agent of Lyme disease...
  15. Orem C, Celik S, Orem A, Calapoglu M, Erdol C. Increased plasma fibronectin levels in patients with acute myocardial infarction complicated with left ventricular thrombus. Thromb Res. 2002;105:37-41 pubmed
    b>Fibronectin is a polymorphic and multifunctional glycoprotein that plays a wide-ranging role in hemostasis...
  16. Graille M, Pagano M, Rose T, Ravaux M, van Tilbeurgh H. Zinc induces structural reorganization of gelatin binding domain from human fibronectin and affects collagen binding. Structure. 2010;18:710-8 pubmed publisher
    ..GBD; 6F(I)-1F(II)-2F(II)-7F(I)-8F(I)-9F(I)), which also corresponds to the C-terminal half of the migration stimulating factor, a Fn splice variant expressed in human breast cancers...
  17. Takano T, Ito Y, Matsuzuka F, Miya A, Kobayashi K, Yoshida H, et al. Expression of oncofetal fibronectin mRNA in thyroid anaplastic carcinoma. Jpn J Clin Oncol. 2007;37:647-51 pubmed
    Oncofetal fibronectin (onfFN) is a fetal protein, the expression of which is observed in papillary thyroid carcinomas but not in follicular tumors or in normal thyroid...
  18. Schwarz Linek U, Pilka E, Pickford A, Kim J, Hook M, Campbell I, et al. High affinity streptococcal binding to human fibronectin requires specific recognition of sequential F1 modules. J Biol Chem. 2004;279:39017-25 pubmed
    b>Fibronectin (Fn) binding by the Streptococcus pyogenes protein SfbI has been shown to trigger integrin-dependent internalization of this pathogen by human epithelial and endothelial cells...
  19. Trial J, Rubio J, Birdsall H, Rodriguez Barradas M, Rossen R. Monocyte activation by circulating fibronectin fragments in HIV-1-infected patients. J Immunol. 2004;173:2190-8 pubmed
    ..Plasma from 63% of patients but none from normal controls contained 110-120 kDa fibronectin fragments (FNf). Presence of FNf did not reflect poor adherence to therapy...
  20. Onaran M, Yilmaz A, Sen I, Ergun M, Camtosun A, Kupeli B, et al. A HindIII polymorphism of fibronectin gene is associated with nephrolithiasis. Urology. 2009;74:1004-7 pubmed publisher
    To evaluate the association between fibronectin gene (FN1) polymorphisms and calcium oxalate nephrolithiasis as a genetic risk factor...
  21. Park J, Katagiri T, Chung S, Kijima K, Nakamura Y. Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. Neoplasia. 2011;13:320-6 pubmed
    ..As one of the critical O-glycan substrates, we identified fibronectin that was O-glycosylated in vivo and thereby stabilized by GALNT6...
  22. Abe Y, Bui Thanh N, Ballantyne C, Burns A. Extra domain A and type III connecting segment of fibronectin in assembly and cleavage. Biochem Biophys Res Commun. 2005;338:1640-7 pubmed
    To determine the role of the extra domain A (EDA) and type III connecting segment (IIICS) of fibronectin in fiber assembly, topographical distribution and proteolytic cleavage, eight full-length human fibronectin cDNA variants (aa0, aa64,..
  23. Telci D, Wang Z, Li X, Verderio E, Humphries M, Baccarini M, et al. Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. J Biol Chem. 2008;283:20937-47 pubmed publisher
    Heterotropic association of tissue transglutaminase (TG2) with extracellular matrix-associated fibronectin (FN) can restore the adhesion of fibroblasts when the integrin-mediated direct binding to FN is impaired using RGD-containing ..
  24. Schor S, Ellis I, Jones S, Baillie R, Seneviratne K, Clausen J, et al. Migration-stimulating factor: a genetically truncated onco-fetal fibronectin isoform expressed by carcinoma and tumor-associated stromal cells. Cancer Res. 2003;63:8827-36 pubmed
    ..A 2.2-kb full-length MSF cDNA has been cloned and shown to be a truncated isoform of fibronectin generated from its primary gene transcript by a hitherto unrecognized intron read-through mechanism...
  25. Akimov S, Belkin A. Cell-surface transglutaminase promotes fibronectin assembly via interaction with the gelatin-binding domain of fibronectin: a role in TGFbeta-dependent matrix deposition. J Cell Sci. 2001;114:2989-3000 pubmed
    Assembly of fibronectin into a fibrillar matrix is critical for regulation of cell growth and migration, embryogenesis and wound healing...
  26. Millard C, Campbell I, Pickford A. Gelatin binding to the 8F19F1 module pair of human fibronectin requires site-specific N-glycosylation. FEBS Lett. 2005;579:4529-34 pubmed
    The gelatin (denatured collagen) binding domain of the extracellular matrix protein fibronectin contains three potential N-glycosylation sites...
  27. Schor S, Schor A. Phenotypic and genetic alterations in mammary stroma: implications for tumour progression. Breast Cancer Res. 2001;3:373-9 pubmed
    ..full-length form of the molecule, and (2) indicating that a previously identified motogenic factor (migration stimulating factor [MSF]) produced by foetal and cancer patient fibroblasts is a genetically generated truncated isoform ..
  28. Liu W, Cheng S, Asa S, Ezzat S. The melanoma-associated antigen A3 mediates fibronectin-controlled cancer progression and metastasis. Cancer Res. 2008;68:8104-12 pubmed publisher
    Tumor cells frequently exhibit decreased adhesiveness due to failure to deposit stromal fibronectin (FN), permitting more rapid proliferation, migration, invasion, and metastasis...
  29. Veevers Lowe J, Ball S, Shuttleworth A, Kielty C. Mesenchymal stem cell migration is regulated by fibronectin through ?5?1-integrin-mediated activation of PDGFR-? and potentiation of growth factor signals. J Cell Sci. 2011;124:1288-300 pubmed publisher
    ..Cell adhesion to fibronectin induced ?5?1-integrin-dependent phosphorylation of PDGFR-? in the absence of growth factor stimulation...
  30. Pickford A, Smith S, Staunton D, Boyd J, Campbell I. The hairpin structure of the (6)F1(1)F2(2)F2 fragment from human fibronectin enhances gelatin binding. EMBO J. 2001;20:1519-29 pubmed
    The solution structure of the (6)F1(1)F2(2)F2 fragment from the gelatin-binding region of fibronectin has been determined (Protein Data Bank entry codes 1e88 and 1e8b)...
  31. Garcia A, Schwarzbauer J, Boettiger D. Distinct activation states of alpha5beta1 integrin show differential binding to RGD and synergy domains of fibronectin. Biochemistry. 2002;41:9063-9 pubmed
    ..integrin can occupy several distinct conformational states which support different strengths of binding to fibronectin [García, A. J., et al. (1998) J. Biol. Chem. 273, 34710-34715]...
  32. Soikkeli J, Podlasz P, Yin M, Nummela P, Jahkola T, Virolainen S, et al. Metastatic outgrowth encompasses COL-I, FN1, and POSTN up-regulation and assembly to fibrillar networks regulating cell adhesion, migration, and growth. Am J Pathol. 2010;177:387-403 pubmed publisher
  33. Zoppi N, Ritelli M, Colombi M. Type III and V collagens modulate the expression and assembly of EDA(+) fibronectin in the extracellular matrix of defective Ehlers-Danlos syndrome fibroblasts. Biochim Biophys Acta. 2012;1820:1576-87 pubmed publisher
    Alternative splicing of EDA fibronectin (FN) region is a cell type- and development-regulated mechanism controlled by pathological processes, growth factors and extracellular matrix (ECM)...
  34. Fattorusso R, Pellecchia M, Viti F, Neri P, Neri D, Wuthrich K. NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure. 1999;7:381-90 pubmed
    ..marker of angiogenesis, consists of 91 amino acid residues that are inserted by alternative splicing into the fibronectin (FN) molecule...
  35. Torre D, Pugliese A, Ferrario G, Marietti G, Forno B, Zeroli C. Interaction of human plasma fibronectin with viral proteins of human immunodeficiency virus. FEMS Immunol Med Microbiol. 1994;8:127-31 pubmed
    b>Fibronectin (FN) is present in soluble and matrix forms in various body fluids and tissues, and has been shown to bind to several pathogens, including viruses...
  36. Tellier M, Greco G, Klotman M, Mosoian A, Cara A, Arap W, et al. Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. J Immunol. 2000;164:3236-45 pubmed
    ..b>Fibronectin is a major component of the extracellular matrix in lymph node tissue, the main site of HIV deposition and ..
  37. Bennett E, Hassan H, Mandel U, Hollingsworth M, Akisawa N, Ikematsu Y, et al. Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy. J Biol Chem. 1999;274:25362-70 pubmed
    ..expressed in WI38 fibroblast cells, indicating that GalNAc-T6 represents a candidate for synthesis of oncofetal fibronectin. The results demonstrate the existence of genetic redundancy of a polypeptide GalNAc-transferase that does not ..
  38. Sharma A, Askari J, Humphries M, Jones E, Stuart D. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. EMBO J. 1999;18:1468-79 pubmed
    The crystal structure of human fibronectin (FN) type III repeats 12-14 reveals the primary heparin-binding site, a clump of positively charged residues in FN13, and a putative minor site approximately 60 A away in FN14...
  39. Wen L, Liu Y, Jiang C, Zeng S, Su Y, Wu W, et al. Comparative Proteomic Profiling and Biomarker Identification of Traditional Chinese Medicine-Based HIV/AIDS Syndromes. Sci Rep. 2018;8:4187 pubmed publisher
  40. Zito G, Richiusa P, Bommarito A, Carissimi E, Russo L, Coppola A, et al. In vitro identification and characterization of CD133(pos) cancer stem-like cells in anaplastic thyroid carcinoma cell lines. PLoS ONE. 2008;3:e3544 pubmed publisher
    ..ARO and KAT-4 were also positive for fetal marker oncofetal fibronectin and negative for thyrocyte-specific differentiating markers thyroglobulin, thyroperoxidase and sodium/iodide ..
  41. Fan L, Wang Q, Liu R, Zong M, He D, Zhang H, et al. Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther. 2012;14:R266 pubmed publisher
    ..This study aimed to investigate the pathogenic role of citrullinated fibronectin (cFn) in RA...
  42. Caluwaerts S. Nubia's mother: being pregnant in the time of experimental vaccines and therapeutics for Ebola. Reprod Health. 2017;14:157 pubmed publisher
    During the 2014-2016 Ebola epidemic, Médecins Sans Frontières (MSF) treated Ebola-positive pregnant women in its Ebola Treatment Centers (ETCs)...
  43. Lee K, Tsai S, Chiu Y, Ho M. Can student self-ratings be compared with peer ratings? A study of measurement invariance of multisource feedback. Adv Health Sci Educ Theory Pract. 2016;21:401-13 pubmed publisher
    ..In medical education, multi-source feedback (MSF) is utilized to assess core competencies, including the professionalism...
  44. Hong H, Zhou T, Fang S, Jia M, Xu Z, Dai Z, et al. Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin. Breast Cancer Res Treat. 2014;148:61-72 pubmed publisher
    ..The metastatic-related molecules including EMT makers, fibronectin, and p-AKT and p-ERK were detected by qRT-PCR, Western blot, and Fluorescent immunocytochemistry...
  45. Labasque M, Devaux J, Leveque C, Faivre Sarrailh C. Fibronectin type III-like domains of neurofascin-186 protein mediate gliomedin binding and its clustering at the developing nodes of Ranvier. J Biol Chem. 2011;286:42426-34 pubmed publisher
    ..Here, we report that fibronectin type III-like (FnIII) domains of both Ig-CAMs mediate their interaction with Gldn in pulldown and cell binding ..
  46. McArthur C, Wang Y, Heruth D, Gustafson S. Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53. Arch Oral Biol. 2001;46:545-55 pubmed
    ..Tat-amplified transcription of the major basement membrane protein laminin, as well as of fibronectin, collagen I and III, and c-myc oncogene was demonstrated...
  47. Trache A, Trzeciakowski J, Gardiner L, Sun Z, Muthuchamy M, Guo M, et al. Histamine effects on endothelial cell fibronectin interaction studied by atomic force microscopy. Biophys J. 2005;89:2888-98 pubmed
    ..AFM probes were labeled with fibronectin and used to measure binding strength between alpha5beta1 integrin and fibronectin by quantifying the force ..
  48. Shimomura Y, Ando H, Furugori K, Kajiyama H, Suzuki M, Iwase A, et al. Possible involvement of crosstalk cell-adhesion mechanism by endometrial CD26/dipeptidyl peptidase IV and embryonal fibronectin in human blastocyst implantation. Mol Hum Reprod. 2006;12:491-5 pubmed
    ..7-fold, P < 0.05). The second part of the present study was to show the expression of fibronectin, a CD26 ligand, in human preimplantation embryos, using the same donated resources...
  49. Lu Y, Ye Y, Yang Q, Shi S. Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes. Kidney Int. 2017;92:504-513 pubmed publisher
    ..Thus, single mesangial cell RNA-seq analysis has provided insights into the functions and underlying mechanisms of mesangial cells. ..
  50. Dalton A, Shlamkovitch T, Papo N, Barton W. Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin. PLoS ONE. 2016;11:e0163732 pubmed publisher
    ..association is significantly enhanced in the presence of the extracellular component and integrin ligand fibronectin. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further ..
  51. Oshima M, Hamba H, Sadr A, Nikaido T, Tagami J. Effect of polymer-based desensitizer with sodium fluoride on prevention of root dentin demineralization. Am J Dent. 2015;28:123-7 pubmed
    ..and 1% oxalic acid (MSO); and MS Coat F containing MS polymer, 1% oxalic acid and 3,000 ppm sodium fluoride (MSF). A window of the dentin surface was treated with each solution...
  52. Peters N, Berg C. Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary. Dev Biol. 2016;409:39-54 pubmed publisher
    ..This genetically tractable system lets us assess the relative contributions that coordinated changes in cell shape, adhesion, orientation, and migration ..
  53. Zhao J, Zhang Y, Sisler J, Shaffer J, Leonard S, Morris A, et al. Assessment of reactive oxygen species generated by electronic cigarettes using acellular and cellular approaches. J Hazard Mater. 2018;344:549-557 pubmed publisher
    ..Reactive oxygen species (ROS) are likely present in e-cig emission and can play an important role in e-cig toxicity. However, e-cig ROS generation is poorly documented...
  54. Kato S, Ohtoko K, Ohtake H, Kimura T. Vector-capping: a simple method for preparing a high-quality full-length cDNA library. DNA Res. 2005;12:53-62 pubmed
    ..5 kbp can be cloned. This method will accelerate comprehensive gene analysis in a variety of eukaryotes. ..
  55. Ito Y, Iwashita J, Kudoh A, Kuramata C, Murata J. MUC5B mucin production is upregulated by fibronectin and laminin in human lung epithelial cells via the integrin and ERK dependent pathway. Biosci Biotechnol Biochem. 2015;79:1794-801 pubmed publisher
    ..We found that MUC5B production in NCI-H292 cells cultured on fibronectin or laminin increased by 4-5-fold, with the increase occurring in a dose- and time-dependent manner...
  56. Makogonenko E, Ingham K, Medved L. Interaction of the fibronectin COOH-terminal Fib-2 regions with fibrin: further characterization and localization of the Fib-2-binding sites. Biochemistry. 2007;46:5418-26 pubmed
    Incorporation of fibronectin into fibrin clots is important for the formation of a provisional matrix that promotes cell adhesion and migration during wound healing...
  57. Hershberger A, Cyders M. "Essentially, All Models are Wrong, but Some Are Useful": A Preliminary Conceptual Model Of Co-Occurring E-Cig and Alcohol Use. Curr Addict Rep. 2017;4:200-208 pubmed publisher
    As prevalence rates of electronic cigarette (e-cig) use increase, researchers and clinicians should not only be paying careful attention to the direct health effects of e-cigs, but also the potential impact e-cigs may have on alcohol use ..
  58. Hamsten C, Wiklundh E, Grönlund H, Schwenk J, Uhlen M, Eklund A, et al. Elevated levels of FN1 and CCL2 in bronchoalveolar lavage fluid from sarcoidosis patients. Respir Res. 2016;17:69 pubmed publisher
    ..Out of these, fibronectin (FN1) and C-C motif chemokine 2 (CCL2) revealed the strongest associations...
  59. Shinde A, Kelsh R, Peters J, Sekiguchi K, Van De Water L, McKeown Longo P. The ?4?1 integrin and the EDA domain of fibronectin regulate a profibrotic phenotype in dermal fibroblasts. Matrix Biol. 2015;41:26-35 pubmed publisher
    Prompt deposition of fibronectin-rich extracellular matrix is a critical feature of normal development and the host-response to injury. Fibronectin isoforms that include the EDA and EDB domains are prominent in these fibronectin matrices...
  60. Goldberg M, Han Y, Yan C, Shaw M, Garner W. TNF-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing. J Invest Dermatol. 2007;127:2645-55 pubmed
    ..myofibroblast (fibroproliferative) phenotypic genes, for example, alpha-SMA, collagen type 1A, and fibronectin at the mRNA level. TNF-alpha suppresses TGF-beta1-induced gene expression by affecting its mRNA stability...
  61. Esnault S, Malter J. Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins. J Immunol. 2003;171:6780-7 pubmed
    ..Cytokine release by Eos is preceded by GM-CSF mRNA stabilization induced by TNF-alpha plus fibronectin. Hyaluronic acid (HA) is a major extracellular matrix proteoglycan, which also accumulates in the lung during ..
  62. Jun H, Jung Y, Choi B. Inflammasome activators induce fibronectin expression and release in macrophages. Cell Microbiol. 2017;19: pubmed publisher
    Extracellular fibronectin (Fn) can activate pro-inflammatory pathways and serves as an endogenous danger signalling molecule; thus, it has been suggested as a biomarker for several diseases...
  63. Duskova E, Hnilicová J, Stanek D. CRE promoter sites modulate alternative splicing via p300-mediated histone acetylation. RNA Biol. 2014;11:865-74 pubmed publisher
    ..acetyltransferase p300 in alternative splicing and showed that knockdown of p300 promotes inclusion of the fibronectin (FN1) alternative EDB exon. p300 associates with CRE sites in the promoter via the CREB transcription factor...
  64. L Heureux D, Rothman V, Tuszynski G. The interaction of angiocidin with tissue transglutaminase. Exp Mol Pathol. 2010;88:15-25 pubmed publisher
    ..angiocidin inhibited cell migration in contrast to monomeric angiocidin and inhibited localization of fibronectin (FN), a pro-tumorigenic matrix protein, into the extracellular matrix (ECM) of tumor and HUVE cells...
  65. Tommasi S, Bates S, Behar R, Talbot P, Besaratinia A. Limited mutagenicity of electronic cigarettes in mouse or human cells in vitro. Lung Cancer. 2017;112:41-46 pubmed publisher
    Electronic cigarettes (e-cig), which are promoted as safe alternatives to tobacco cigarettes or as aides to smoking cessation, are becoming increasingly popular among adult chronic smokers and adolescents experimenting with tobacco ..
  66. Schmidt D, Kao W. The interrelated role of fibronectin and interleukin-1 in biomaterial-modulated macrophage function. Biomaterials. 2007;28:371-82 pubmed
    ..The extracellular matrix (ECM) protein fibronectin (FN) is recognized by macrophages and frequently used in biomaterial modification to elicit greater cellular ..