Gene Symbol: fibrinogen
Description: fibrinogen alpha chain
Alias: Fib2, fibrinogen alpha chain, fibrinogen, A alpha polypeptide
Species: human
Products:     fibrinogen

Top Publications

  1. Alving B, Henschen A. Fibrinogen giessen I: a congenital homozygously expressed dysfibrinogenemia with A alpha 16 Arg----His substitution. Am J Hematol. 1987;25:479-82 pubmed
    ..The patients, both of whom have a bleeding diathesis, have amino acid substitutions in the fibrinogen molecule at A alpha 16 Arg----Cys and A alpha 19 Arg----Ser, respectively...
  2. Herrick S, Blanc Brude O, Gray A, Laurent G. Fibrinogen. Int J Biochem Cell Biol. 1999;31:741-6 pubmed
    b>Fibrinogen is a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots...
  3. Kotlin R, Blazek B, Suttnar J, Maly M, Kvasnicka J, Dyr J. Dysfibrinogenemia in childhood: two cases of congenital dysfibrinogens. Blood Coagul Fibrinolysis. 2010;21:640-8 pubmed publisher
    A 2-year-old asymptomatic boy and his relatives were investigated for a suspected fibrinogen mutation after coagulation tests revealed a decreased functional fibrinogen level (family A)...
  4. Doolittle R. Fibrinogen and fibrin. Annu Rev Biochem. 1984;53:195-229 pubmed
  5. Huang S, Cao Z, Chung D, Davie E. The role of betagamma and alphagamma complexes in the assembly of human fibrinogen. J Biol Chem. 1996;271:27942-7 pubmed
    The role of alphagamma and betagamma dimers as intermediates in the assembly of fibrinogen was examined in cell fusion experiments using stably transfected baby hamster kidney cell lines expressing one or combinations of fibrinogen chains...
  6. Tsurupa G, Medved L. Identification and characterization of novel tPA- and plasminogen-binding sites within fibrin(ogen) alpha C-domains. Biochemistry. 2001;40:801-8 pubmed
    ..These results indicate that the fibrinogen alphaC-domains contain novel high-affinity tPA- and Pg-binding sites that play an important role in the ..
  7. Redman C, Xia H. Fibrinogen biosynthesis. Assembly, intracellular degradation, and association with lipid synthesis and secretion. Ann N Y Acad Sci. 2001;936:480-95 pubmed
    Plasma fibrinogen is synthesized primarily in hepatocytes and assembly of the three component chains (A alpha, B beta, and gamma) into its final form as a six-chain dimer (A alpha, B beta, gamma)2 occurs rapidly in the lumen of the ..
  8. Tsurupa G, Tsonev L, Medved L. Structural organization of the fibrin(ogen) alpha C-domain. Biochemistry. 2002;41:6449-59 pubmed
    We hypothesized that the alpha C-domain of human fibrinogen (residues hA alpha 221-610) and of other species consists of a compact COOH-terminal region (hA alpha 392-610) and a flexible NH(2)-terminal connector region (hA alpha 221-391) ..
  9. Standeven K, Grant P, Carter A, Scheiner T, Weisel J, Ariens R. Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function. Circulation. 2003;107:2326-30 pubmed
    The fibrinogen Aalpha Thr312Ala polymorphism occurs within the alphaC domain of fibrinogen, which is important for lateral aggregation and factor XIII-induced cross-linking of fibrin fibers...

More Information

Publications118 found, 100 shown here

  1. Mannila M, Eriksson P, Lundman P, Samnegard A, Boquist S, Ericsson C, et al. Contribution of haplotypes across the fibrinogen gene cluster to variation in risk of myocardial infarction. Thromb Haemost. 2005;93:570-7 pubmed
    b>Fibrinogen has consistently been recognized as an independent predictor of myocardial infarction (MI)...
  2. Mannila M, Eriksson P, Ericsson C, Hamsten A, Silveira A. Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction. Thromb Haemost. 2006;95:420-7 pubmed
    An intricate interplay between the genes encoding fibrinogen gamma (FGG), alpha (FGA) and beta (FGB), coagulation factor XIII (F13A1) and interleukin 6 (IL6) and environmental factors is likely to influence plasma fibrinogen concentration,..
  3. Kardys I, Uitterlinden A, Hofman A, Witteman J, de Maat M. Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study. Thromb Haemost. 2007;97:288-95 pubmed
    Fibrin network structure has been correlated with coronary disease. Fibrinogen gamma and alpha (FGG and FGA) gene haplotypes (chromosome 4q28) may be associated with fibrin network structure, and thereby with rigidity of the fibrin clot ..
  4. Jacquemin B, Antoniades C, Nyberg F, Plana E, Müller M, Greven S, et al. Common genetic polymorphisms and haplotypes of fibrinogen alpha, beta, and gamma chains affect fibrinogen levels and the response to proinflammatory stimulation in myocardial infarction survivors: the AIRGENE study. J Am Coll Cardiol. 2008;52:941-52 pubmed publisher
    This study was designed to investigate whether single nucleotide polymorphisms (SNPs) and haplotypes of the fibrinogen gene-cluster (fibrinogen chains alpha [FGA], beta [FGB], and gamma [FGG]) could explain the inter- and intraindividual ..
  5. Peters A, Greven S, Heid I, Baldari F, Breitner S, Bellander T, et al. Fibrinogen genes modify the fibrinogen response to ambient particulate matter. Am J Respir Crit Care Med. 2009;179:484-91 pubmed publisher
    Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis...
  6. Siegerink B, Rosendaal F, Algra A. Genetic variation in fibrinogen; its relationship to fibrinogen levels and the risk of myocardial infarction and ischemic stroke. J Thromb Haemost. 2009;7:385-90 pubmed publisher common causes and reverse causation have been proposed as explanations for the association between high fibrinogen levels and cardiovascular disease...
  7. Kotlin R, Suttnar J, Cápová I, Hrachovinova I, Urbánková M, Dyr J. Fibrinogen Šumperk II: dysfibrinogenemia in an individual with two coding mutations. Am J Hematol. 2012;87:555-7 pubmed publisher
    b>Fibrinogen—a 340-kDa glycoprotein—plays a crucial role in blood coagulation, platelet aggregation, wound healing, and other physiological processes...
  8. Uitte de Willige S, de Visser M, Houwing Duistermaat J, Rosendaal F, Vos H, Bertina R. Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen gamma' levels. Blood. 2005;106:4176-83 pubmed
    We investigated the association between haplotypes of fibrinogen alpha (FGA), beta (FGB), and gamma (FGG), total fibrinogen levels, fibrinogen gamma' (gammaA/gamma' plus gamma'/gamma') levels, and risk for deep venous thrombosis...
  9. Mannila M, Eriksson P, Leander K, Wiman B, de Faire U, Hamsten A, et al. The association between fibrinogen haplotypes and myocardial infarction in men is partly mediated through pleiotropic effects on the serum IL-6 concentration. J Intern Med. 2007;261:138-47 pubmed
    b>Fibrinogen haplotypes have been associated with risk of myocardial infarction (MI), independently of plasma fibrinogen concentration, and experimental data indicate that fibrinogen exerts pleiotropic effects on interleukin 6 (IL-6) ..
  10. Suntharalingam J, Goldsmith K, Van Marion V, Long L, Treacy C, Dudbridge F, et al. Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension. Eur Respir J. 2008;31:736-41 pubmed
    ..inhibitor-1 4G/5G, tissue plasminogen activator 7351 cytosine (C)>thymidine (T), Factor XIII 100G>T, fibrinogen Aalpha substitution of threonine with alanine at position 312 (Thr312Ala), fibrinogen Bbeta substitution of ..
  11. Koch W, Hoppmann P, Biele J, Mueller J, Schomig A, Kastrati A. Fibrinogen genes and myocardial infarction: a haplotype analysis. Arterioscler Thromb Vasc Biol. 2008;28:758-63 pubmed publisher
    b>Fibrinogen has a role in inflammatory processes and participates in atherosclerotic plaque formation...
  12. Carty C, Cushman M, Jones D, Lange L, Hindorff L, Rice K, et al. Associations between common fibrinogen gene polymorphisms and cardiovascular disease in older adults. The Cardiovascular Health Study. Thromb Haemost. 2008;99:388-95 pubmed publisher
    Elevated plasma fibrinogen is a risk factor for cardiovascular disease (CVD), but associations between fibrinogen single nucleotide polymorphisms (SNPs) and disease risk are inconsistent...
  13. Casini A, Neerman Arbez M, Ariëns R, de Moerloose P. Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management. J Thromb Haemost. 2015;13:909-19 pubmed publisher
    Congenital dysfibrinogenemia is a qualitative congenital fibrinogen disorder characterized by normal antigen levels of a dysfunctional fibrinogen...
  14. Simurda T, Zolkova J, Snahnicanova Z, Loderer D, Skornova I, Sokol J, et al. Identification of Two Novel Fibrinogen B? Chain Mutations in Two Slovak Families with Quantitative Fibrinogen Disorders. Int J Mol Sci. 2017;19: pubmed publisher
    Congenital fibrinogen disorders are caused by mutations in one of the three fibrinogen genes that affect the synthesis, assembly, intracellular processing, stability or secretion of fibrinogen...
  15. Stephen J, Nampoothiri S, Vinayan K, Yesodharan D, Remesh P, Gahl W, et al. Cortical atrophy and hypofibrinogenemia due to FGG and TBCD mutations in a single family: a case report. BMC Med Genet. 2018;19:80 pubmed publisher
    ..Hereditary fibrinogen deficiencies result from mutations in the genes FGA, FGB, and FGG, encoding the three different polypeptide ..
  16. Asselta R, Platè M, Robusto M, Borhany M, Guella I, Soldà G, et al. Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency. Thromb Haemost. 2015;113:567-76 pubmed publisher
    b>Fibrinogen is a plasma glycoprotein mainly synthesised by hepatocytes and circulating as a 340-kDa hexamer consisting of two sets of three different polypeptide chains (Aα, Bβ, and γ, encoded by the FGA, FGB, and FGG gene, ..
  17. Ivaskevicius V, Ruhl H, Detarsio G, Biswas A, Gupta S, Davoli M, et al. A novel missense mutation in the FGB gene (p.Gly302Arg) leading to afibrinogenemia. Predicted structure and function consequences. Hamostaseologie. 2016;36:S34-S38 pubmed
    Afibrinogenemia represents the rarest form of fibrinogen deficiency. Causative missense mutations occur rarely and may improve the understanding of fibrinogen structure and function...
  18. Liu F, Zhao C, Liu L, Ding H, Huo R, Shi Z. Peptidome profiling of umbilical cord plasma associated with gestational diabetes-induced fetal macrosomia. J Proteomics. 2016;139:38-44 pubmed publisher
    ..7Da differentially expressed between GDM cases and compared controls. A precursor protein of 1077.2Da was fibrinogen alpha chain (FGA), which was also identified in the Ai et al...
  19. Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
    ..Data are available via ProteomeXchange with identifier PXD005953. ..
  20. Chukkapalli S, Velsko I, Rivera Kweh M, Zheng D, Lucas A, Kesavalu L. Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice. PLoS ONE. 2015;10:e0143291 pubmed publisher
    ..This study demonstrates unique differences in the host immune response to a polybacterial periodontal infection with atherosclerotic lesion progression in a mouse model. ..
  21. Bin Q, Liang F, Ou D, Cui H, Luo J. Two symptomatic cases of dysfibrinogenemia in China: one with gamma-chain Arg275Cys mutation and another without detectable mutation in fibrinogen genes. Blood Coagul Fibrinolysis. 2015;26:564-71 pubmed publisher
    ..b>Fibrinogen genes, including FGA, FGB and FGG of all participants were PCR-amplified, followed by direct sequencing...
  22. Jiang L, Zhang Q, Xu W, Zhang Y. [Mutation analysis of a FGG gene causing hereditary abnormal fibrinogen]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:812-814 pubmed publisher
    ..of 5 people) of prothrombin time(PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen activity (Fg: C), D-dimer (D-D), fibrinogen and fibrin degradation products (FDPs), plasminogen activity (PLG: A)..
  23. Wang Y, Ding H, Hao X, Zhu L, Yang L, Jin Y, et al. [Congenital hypofibrinogenemia associated with a novel mutation in FGG gene]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:331-4 pubmed publisher
    ..The activity of fibrinogen (Fg:C) and fibrinogen antigen (Fg:Ag) were measured respectively with the Clauss method and immunoturbidimetry...
  24. Yan J, Deng D, Deng X, Luo M, Cheng P, Liao L, et al. [Analysis of a family with congenital dysfibrinogenemia caused by an Arg275His mutation in the gamma chain of fibrinogen]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016;33:160-3 pubmed publisher
    ..Plasma fibrinogen was extracted and analyzed with SDS-PAGE electrophoresis...
  25. Zhang Y, Liu S, Zhang Z, Tao X, Peng X, Kong Y. [Genetic Analysis of A Case of Congenital Dysfibrinogenemia Caused by Arg16His Mutation in Exon 2 of FGA]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1514-1517 pubmed publisher
    ..The quality and quantity of fibrinogen in plasma were determined by Clauss and electrophoresis, respectively...
  26. Duan B, Bai J, Qiu J, Wang J, Tong C, Wang X, et al. Histone-lysine N-methyltransferase SETD7 is a potential serum biomarker for colorectal cancer patients. EBioMedicine. 2018;37:134-143 pubmed publisher
    ..Knockdown of SETD7 inhibited cancer cell proliferation, induced G1/S cell cycle arrest and increased apoptosis. Our data indicate that SETD7 could serve as a potential diagnostic and prognostic biomarker for CRC. ..
  27. Ward Caviness C, Huffman J, Evertt K, Germain M, van Dongen J, Hill W, et al. DNA methylation age is associated with an altered hemostatic profile in a multi-ethnic meta-analysis. Blood. 2018;: pubmed publisher
    ..For fibrinogen, we used European and African-ancestry participants who were meta-analyzed separately and combined via a random ..
  28. Cote D, Smith T, Sandler C, Gupta T, Bale T, Bi W, et al. Functional Gonadotroph Adenomas: Case Series and Report of Literature. Neurosurgery. 2016;79:823-831 pubmed
    ..FGA, functional gonadotroph adenomaFSH, follicle-stimulating hormoneLH, luteinizing hormoneTSH, thyroid-stimulating hormone. ..
  29. Francesco F, Cervone A. Metabolic alterations associated with first and second generation antipsychotics: an twenty-years open study. Psychiatr Danub. 2014;26 Suppl 1:184-7 pubmed
    ..Optimal monitoring should include assessments of fasting glucose, lipids, cholesterol, and blood pressure. ..
  30. Shlebak A, Katsarou A, Adams G, Fernando F. A novel mutation in exon 2 of FGB caused by c.221G>T † substitution, predicting the replacement of the native Arginine at position 74 with a Leucine (p.Arg74Leu † ) in a proband from a Kurdish family with dysfibrinogenaemia and familial venous and. J Thromb Thrombolysis. 2017;43:263-270 pubmed publisher
    Dysfibrinogenaemias may present in either congenital or acquired form and are disorders of fibrinogen structure which may or may not be associated with abnormal function...
  31. Zhang Y, Kim D, Jung Y, Kim Y, Lee Y, Kim J, et al. Inverse agonist of ERR? reduces cannabinoid receptor type 1-mediated induction of fibrinogen synthesis in mice with a high-fat diet-intoxicated liver. Arch Toxicol. 2018;92:2885-2896 pubmed publisher
    Upon liver intoxication with malnutrition or high-fat diet feeding, fibrinogen is synthesized by hepatocytes and secreted into the blood in human and mouse...
  32. Wang D, Gopinath S, Lagacé R, Norona W, Hennessy L, Short M, et al. Developmental validation of the GlobalFiler(®) Express PCR Amplification Kit: A 6-dye multiplex assay for the direct amplification of reference samples. Forensic Sci Int Genet. 2015;19:148-155 pubmed publisher
    ..The validation results demonstrate that the 24-locus multiplex kit is a robust and reliable identification assay as required for forensic DNA typing and databasing. ..
  33. Verdoux H, Pambrun E, Tournier M, Bezin J, Pariente A. Antipsychotic long-acting injections: A community-based study from 2007 to 2014 of prescribing trends and characteristics associated with initiation. Schizophr Res. 2016;178:58-63 pubmed publisher
    ..It is of interest to explore whether similar prescribing trends are observed in other countries and to further assess the effectiveness of new LAIs in real-life conditions. ..
  34. Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, et al. An A alpha Ser-434 to N-glycosylated Asn substitution in a dysfibrinogen, fibrinogen Caracas II, characterized by impaired fibrin gel formation. J Biol Chem. 1991;266:11575-81 pubmed
    ..a unique N-glycosylated Asn substitution for a Ser at position 434 of the A alpha chain of an abnormal fibrinogen designated fibrinogen Caracas II. This dysfibrinogen was characterized by impaired fibrin monomer aggregation...
  35. Itarte E, Plana M, Guasch M, Martos C. Phosphorylation of fibrinogen by casein kinase 1. Biochem Biophys Res Commun. 1983;117:631-6 pubmed
    Casein kinase 1 phosphorylated human fibrinogen, in a reaction that did not use GTP as phosphoryl donor and was neither stimulated by cyclic AMP or Ca2+, nor inhibited by the cyclic AMP-dependent protein kinase inhibitor protein...
  36. Asselta R, Duga S, Spena S, Santagostino E, Peyvandi F, Piseddu G, et al. Congenital afibrinogenemia: mutations leading to premature termination codons in fibrinogen A alpha-chain gene are not associated with the decay of the mutant mRNAs. Blood. 2001;98:3685-92 pubmed
    ..with autosomal recessive inheritance, characterized by the complete absence or extremely reduced levels of fibrinogen in patients' plasma and platelets...
  37. Serpell L, Benson M, Liepnieks J, Fraser P. Structural analyses of fibrinogen amyloid fibrils. Amyloid. 2007;14:199-203 pubmed
    Hereditary fibrinogen amyloidosis is characterized by deposition of amyloid fibrils in renal glomeruli. The subunit protein of the amyloid fibrils is a proteolytic fragment of the fibrinogen Aalpha-chain...
  38. Lange L, Reiner A, Carty C, Jenny N, Cushman M, Lange E. Common genetic variants associated with plasma fibrin D-dimer concentration in older European- and African-American adults. J Thromb Haemost. 2008;6:654-9 pubmed publisher
    ..Several fibrinogen gene polymorphisms, including the Thr312Ala Aalpha chain variant and the FGG-10034 C/T variant, were associated ..
  39. Jacewicz R, Markiewicz B, Wojtkiewicz R, Jedrzejczyk M, Berent J. Population database on: D1S1656, D2S441, D2S1338, D3S1358, D8S1179, D10S1248, D22S1045, D12S391, D16S539, D18S51, D19S433, D21S11, FGA, TH01, vWA loci included in NGM system based on one thousand unrelated individuals from Lodz region of Central Pola. Arch Med Sadowej Kryminol. 2016;66:83-94 pubmed publisher
    ..Porównanie mi?dzypopulacyjne przeprowadzone metod? „najbli?szego s?siada" oraz skalowania wielowymiarowego zobrazowa?o genetyczne dystanse dziel?ce badan? polsk? populacj? od innych populacji Polski, Europy i ?wiata. ..
  40. Wu C, Chung A. Potential role of entactin in hemostasis. Specific interaction of entactin with fibrinogen A alpha and B beta chains. J Biol Chem. 1991;266:18802-7 pubmed
    ..We have demonstrated, for the first time, that entactin interacts with fibrinogen in a specific manner. Entactin binding sites have been localized to the A alpha and B beta chains of fibrinogen...
  41. Ni F, Konishi Y, Frazier R, Scheraga H, Lord S. High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen. Biochemistry. 1989;28:3082-94 pubmed
    The interaction of the following human fibrinogen-like peptides with bovine thrombin was studied by use of one- and two-dimensional NMR techniques in aqueous solution: Ala(1)-Asp-Ser-Gly-Glu-Gly-Asp-Phe(8)-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg(..
  42. Adams G, Snieder H, McKie V, Clair B, Brambilla D, Adams R, et al. Genetic risk factors for cerebrovascular disease in children with sickle cell disease: design of a case-control association study and genomewide screen. BMC Med Genet. 2003;4:6 pubmed
    ..The polymorphisms include mutations in coagulation factor genes (Factor V, Prothrombin, Fibrinogen, Factor VII, Factor XIII, PAI-1), platelet activation/function (GpIIb/IIIa, GpIb IX-V, GpIa/IIa), vascular ..
  43. Galanakis D, Neerman Arbez M, Scheiner T, Henschen A, Hubbs D, Nagaswami C, et al. Homophenotypic Aalpha R16H fibrinogen (Kingsport): uniquely altered polymerization associated with slower fibrinopeptide A than fibrinopeptide B release. Blood Coagul Fibrinolysis. 2007;18:731-7 pubmed
    ..analyses revealed unimpaired fibrin repolymerization, and abnormal thrombin-induced polymerization (1-7 mumol/l fibrinogen, > 96% coagulable), consisting of a prolonged lag time, slow rate, and abnormal clot turbidity maxima, all ..
  44. Kielmas M, Szewczuk Z, Stefanowicz P. A study on human serum albumin influence on glycation of fibrinogen. Biochem Biophys Res Commun. 2013;439:78-83 pubmed publisher
    ..The aim of our study was to test the influence of human serum albumin (HSA) on glycation of fibrinogen. The isotopic labeling using [(13)C6] glucose combined with LC-MS were applied as tool for identification ..
  45. Koopman J, Haverkate F, Grimbergen J, Lord S, Mosesson M, DiOrio J, et al. Molecular basis for fibrinogen Dusart (A alpha 554 Arg-->Cys) and its association with abnormal fibrin polymerization and thrombophilia. J Clin Invest. 1993;91:1637-43 pubmed
    The molecular defect in the abnormal fibrinogen Dusart (Paris V) that is associated with thrombophilia was determined by sequence analysis of genomic DNA that had been amplified using the polymerase chain reaction...
  46. Le Gal G, Delahousse B, Lacut K, Malaviolle V, Regina S, Blouch M, et al. Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism. Thromb Res. 2007;121:333-8 pubmed
    b>Fibrinogen Aalpha-Thr312Ala and Factor XIII Val34Leu polymorphisms have been shown to modify fibrin clot structure and function...
  47. Pruissen D, Rosendaal F, Gorter J, Garcia A, Kappelle L, Algra A. Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin. J Neurol. 2007;254:1660-5 pubmed
    ..AB0 blood group and 11 haemostatic genetic variants were investigated. The Thr312Ala variant of the alpha fibrinogen gene was associated with a decreased bleeding risk (odds ratio (OR) 0...
  48. Eriksson M, Schönland S, Bergner R, Hegenbart U, Lohse P, Schmidt H, et al. Three German fibrinogen Aalpha-chain amyloidosis patients with the p.Glu526Val mutation. Virchows Arch. 2008;453:25-31 pubmed publisher
    Plasma protein fibrinogen variants cause fibrinogen A alpha-chain (AFib) amyloidosis, which presents with hypertension, proteinuria, and azotemia. Six AFib mutations have been reported thus far...
  49. Kotlin R, Reicheltová Z, Maly M, Suttnar J, Sobotková A, Salaj P, et al. Two cases of congenital dysfibrinogenemia associated with thrombosis - Fibrinogen Praha III and Fibrinogen Plzen. Thromb Haemost. 2009;102:479-86 pubmed publisher
    Congenital dysfibrinogenemia is a rare disease characterised by inherited abnormality in the fibrinogen molecule, resulting in functional defects...
  50. Gorski M, Lotta L, Pappalardo E, de Haan H, Passamonti S, van Hylckama Vlieg A, et al. Single Nucleotide Variant rs2232710 in the Protein Z-Dependent Protease Inhibitor (ZPI, SERPINA10) Gene Is Not Associated with Deep Vein Thrombosis. PLoS ONE. 2016;11:e0151347 pubmed publisher
  51. Yang C, Ba H, Tan X, Zhao H, Zhang S, Yu H. [Association of aggressive behaviors of schizophrenia with short tandem repeats loci]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:901-904 pubmed publisher
    ..0001), with the OR being 1.81 (95%CI: 1.22-2.67) and 4.33 (95%CI: 1.95-9.59), respectively. Penta D may be associated with aggressive behaviors of schizophrenia. Allele 10 and genotypes 10-12 of Penta D may confer a risk for the disease. ..
  52. Hawiger J, Timmons S, Kloczewiak M, Strong D, Doolittle R. gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors. Proc Natl Acad Sci U S A. 1982;79:2068-71 pubmed
    b>Fibrinogen, a clottable plasma protein, agglutinates both prokaryotic cells (e.g., staphylococci) and eukaryotic cell fragments (e.g., platelets) through interaction with specific receptors...
  53. Zhang J, Redman C. Fibrinogen assembly and secretion. Role of intrachain disulfide loops. J Biol Chem. 1996;271:30083-8 pubmed
    Human fibrinogen is a homodimer composed of three different (Aalpha, Bbeta, gamma) polypeptide chains. The chains are linked by 29 inter- and intrachain disulfide bonds...
  54. Everse S, Spraggon G, Veerapandian L, Riley M, Doolittle R. Crystal structure of fragment double-D from human fibrin with two different bound ligands. Biochemistry. 1998;37:8637-42 pubmed
    ..Additionally, we have found that the beta-chain domain, like its gamma-chain counterpart, binds calcium. ..
  55. Sivalingam V, Patel B. Familial mutations in fibrinogen A? (FGA) chain identified in renal amyloidosis increase in vitro amyloidogenicity of FGA fragment. Biochimie. 2016;127:44-9 pubmed publisher
    ..Aggregation of several proteins such as immunoglobulin light chain, fibrinogen A? chain (FGA) and lysozyme have been found to be associated with renal amyloidosis...
  56. Hong T, Shen D, Chen X, Wu X, Hua D. Preoperative plasma fibrinogen, but not D-dimer might represent a prognostic factor in non-metastatic colorectal cancer: A prospective cohort study. Cancer Biomark. 2017;19:103-111 pubmed publisher
    ..We conducted a prospective cohort study to validate the prognostic significance of three hemostasis parameters - fibrinogen, fibrin degradation products (FDPs) and D-dimer - in non-metastatic colorectal cancer patients treated with ..
  57. Sheen C, Brennan S, Jabado N, George P. Fibrinogen Montreal: a novel missense mutation (Aa D496N) associated with hypofibrinogenaemia. Thromb Haemost. 2006;96:231-2 pubmed
  58. Wypasek E, Stepien E, Pieculewicz M, Podolec P, Undas A. Factor XIII Val34Leu polymorphism and ischaemic stroke in patients with patent foramen ovale. Thromb Haemost. 2009;102:1280-2 pubmed publisher
  59. Jozwiak Bebenista M, Jasińska Stroschein M, Kowalczyk E. The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77:205-213 pubmed
    ..The results of the present paper confirm the findings that BDNF may represent the key target for olanzapine and PACAP. ..
  60. Blanquet M, Petersen J, Palla A, Veraguth D, Weber K, Straumann D, et al. Vestibulo-cochlear function in inflammatory neuropathies. Clin Neurophysiol. 2018;129:863-873 pubmed publisher
    ..While our data does not support routine vestibular testing in inflammatory neuropathies, this may be considered in selected cases. ..
  61. Collen A, Maas A, Kooistra T, Lupu F, Grimbergen J, Haas F, et al. Aberrant fibrin formation and cross-linking of fibrinogen Nieuwegein, a variant with a shortened Aalpha-chain, alters endothelial capillary tube formation. Blood. 2001;97:973-80 pubmed
    A congenital dysfibrinogenemia, fibrinogen(Nieuwegein), was discovered in a young man without any thromboembolic complications or bleeding...
  62. Shattil S. Integrins and Src: dynamic duo of adhesion signaling. Trends Cell Biol. 2005;15:399-403 pubmed
    ..Here, the biochemical basis for and biological significance of this integrin-SFK interaction is summarized, and I propose a general mechanism for initiation of outside-in integrin signaling. ..
  63. Rubattu S, Speranza R, Ferrari M, Evangelista A, Beccia M, Stanzione R, et al. A role of TNF-alpha gene variant on juvenile ischemic stroke: a case-control study. Eur J Neurol. 2005;12:989-93 pubmed
    ..The whole population was screened for polymorphisms belonging to genes encoding FII, FV, alpha-fibrinogen, beta-fibrinogen, GP IIb/IIIa, tumor necrosis factor (TNF)-alpha, interleukin 1-beta...
  64. Bamford C, Fenno J, Jenkinson H, Dymock D. The chymotrypsin-like protease complex of Treponema denticola ATCC 35405 mediates fibrinogen adherence and degradation. Infect Immun. 2007;75:4364-72 pubmed
    ..T. denticola bacteria interact with a range of host tissue proteins, including fibronectin, laminin, and fibrinogen. The latter localizes in the extracellular matrix where tissue damage has occurred, and interactions with ..
  65. de Moerloose P, Casini A, Neerman Arbez M. Congenital fibrinogen disorders: an update. Semin Thromb Hemost. 2013;39:585-95 pubmed publisher
    Hereditary fibrinogen abnormalities comprise two classes of plasma fibrinogen defects: Type I, afibrinogenemia or hypofibrinogenemia, which has absent or low plasma fibrinogen antigen levels (quantitative fibrinogen deficiencies), and ..
  66. Tamura T, Arai S, Nagaya H, Mizuguchi J, Wada I. Stepwise assembly of fibrinogen is assisted by the endoplasmic reticulum lectin-chaperone system in HepG2 cells. PLoS ONE. 2013;8:e74580 pubmed publisher
    ..Here, we show that the maturation of fibrinogen, a hexameric secretory protein (two trimers from ?, ? and ? subunits), occurs in a stepwise manner...
  67. Brennan S, Laurie A, Mo A, Grigg A. Novel fibrinogen mutations (Aα17Gly→Cys and Aα381Ser→Phe) occurring with a 312Thr→Ala polymorphism: allelic phase assigned by direct mass measurement. Blood Coagul Fibrinolysis. 2015;26:882-6 pubmed publisher
    ..Functional fibrinogen abnormalities can be benign or may lead to bleeding or thrombotic conditions...
  68. Li Z, Zhang Y, Jiang Z, Jin X, Zhang K, Wang X, et al. Hijacking of the nucleolar protein fibrillarin by TGB1 is required for cell-to-cell movement of Barley stripe mosaic virus. Mol Plant Pathol. 2017;: pubmed publisher
    ..that TGB1 interacts directly with the glycine-arginine-rich (GAR) domain of the nucleolar protein fibrillarin (Fib2)...
  69. Siebenlist K, Prchal J, Mosesson M. Fibrinogen Birmingham: a heterozygous dysfibrinogenemia (A alpha 16 Arg----His) containing heterodimeric molecules. Blood. 1988;71:613-8 pubmed
    b>Fibrinogen was isolated from the plasma of a 25-year-old female with a history of mild bleeding and several recent moderate to severe hemorrhagic episodes...
  70. Kotschy D, Kotschy M, Socha P, Masłowski L, Kwapisz J, Żuk N, et al. Tissue factor and other hemostatic parameters in patients with advanced peripheral artery disease after endovascular revascularization - search for hemostatic factors which indicate restenosis. Adv Clin Exp Med. 2015;24:93-8 pubmed publisher
    ..of tissue factor (TF), tissue factor pathway inhibitor (TFPI), thrombin-antithrombin (TAT) complexes, fibrinogen and D-dimers in the blood of patients with PAD after peripheral endovascular revascularization of the lower legs ..
  71. Reber P, Furlan M, Beck E, Barbui T. Fibrinogen Bergamo III and fibrinogen Torino: two further variants with hereditary molecular defects in fibrinopeptide A. Thromb Res. 1987;46:163-7 pubmed
  72. Wierzbicka I, Kowalska M, Lasz E, Farrell D, Budzynski A, Niewiarowski S. Interaction of beta 3 integrin-derived peptides 214-218 and 217-231 with alpha IIb beta 3 complex and with fibrinogen A alpha-chain. Thromb Res. 1997;85:115-26 pubmed
    ..3 integrin-derived peptides 214-218 and 217-231 have been shown previously to inhibit platelet aggregation and fibrinogen binding to platelets and to purified receptor...
  73. Menegatti M, Asselta R, Duga S, Malcovati M, Bucciarelli P, Mannucci P, et al. Identification of four novel polymorphisms in the Aalpha and gamma fibrinogen genes and analysis of association with plasma levels of the protein. Thromb Res. 2001;103:299-307 pubmed
    Four novel polymorphisms were identified in the fibrinogen gene cluster...
  74. Margaglione M, Vecchione G, Santacroce R, D Angelo F, Casetta B, Papa M, et al. A frameshift mutation in the human fibrinogen Aalpha-chain gene (Aalpha(499)Ala frameshift stop) leading to dysfibrinogen San Giovanni Rotondo. Thromb Haemost. 2001;86:1483-8 pubmed
    We have investigated a 53-yr-old asymptomatic white man with decreased functional, but not immunologic, fibrinogen plasma levels together with prolonged thrombin and reptilase times, detected through routine coagulation studies prior to a ..
  75. Mathonnet F, Peltier J, Detruit H, de Raucourt E, Alvarez J, Mazmanian G, et al. Fibrinogen Saint-Germain I: a case of the heterozygous Aalpha GLY 12 --> VAL fibrinogen variant. Blood Coagul Fibrinolysis. 2002;13:149-53 pubmed
    A fibrinogen variant was suspected based on the results of routine coagulation tests in a 2-year-old asymptomatic child...
  76. Kathiresan S, Yang Q, Larson M, Camargo A, Tofler G, Hirschhorn J, et al. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006;26:1405-12 pubmed
    ..In a reference panel, we characterized LD structure at the fibrinogen gene cluster (fibrinogen-beta[FGB], FGA, and FGG), factor VII (F7), and tissue plasminogen activator (PLAT) loci...
  77. Jones J, McGonigle N, McAnespie M, Cran G, Graham A. Plasma fibrinogen and serum C-reactive protein are associated with non-small cell lung cancer. Lung Cancer. 2006;53:97-101 pubmed
    There is an association between coagulation and lung cancer. Therefore, pre-operative plasma fibrinogen and serum C-reactive protein (CRP) concentration were assessed to determine their association with tumour characteristics and to ..
  78. Tsurupa G, Yakovlev S, Pechik I, Lamanuzzi L, Angles Cano E, Medved L. Interaction of fibrin(ogen) with apolipoprotein(a): further characterization and identification of a novel lysine-dependent apolipoprotein(a)-binding site within the gamma chain 287-411 region. Biochemistry. 2006;45:10624-32 pubmed
    ..The experiments revealed that the apo(a)-binding site, identified previously within fibrinogen gamma chain residues 207-235 [Klose, R., et al. (2000) J. Biol. Chem...
  79. Lord S. Fibrinogen and fibrin: scaffold proteins in hemostasis. Curr Opin Hematol. 2007;14:236-41 pubmed
    Elevated fibrinogen is a cardiovascular risk factor. Recent work provides a rationale for this risk, as abnormal fibrin clot structure, strength and stability correlates with coronary artery disease...
  80. Ono M, Matsubara J, Honda K, Sakuma T, Hashiguchi T, Nose H, et al. Prolyl 4-hydroxylation of alpha-fibrinogen: a novel protein modification revealed by plasma proteomics. J Biol Chem. 2009;284:29041-9 pubmed publisher
    ..Here, we describe successful detection of novel prolyl hydroxylation of alpha-fibrinogen using 2DICAL, based on comparison of plasma samples of 38 pancreatic cancer patients and 39 healthy subjects...
  81. Galanakis D, Mosesson M. Human fibrinogen heterogeneities: determination of the major Aalpha chain derivatives in blood. Thromb Res. 1983;31:403-13 pubmed
    Most plasma fibrinogen molecules, when analyzed by Na Dod SO4 polyacrylamide gel electrophoresis migrate in three major positions, designated bands I, II, and III, respectively...
  82. Bahadori B, Uitz E, Dehchamani D, Pilger E, Renner W. The fibrinogen gamma 10034C>T polymorphism is not associated with Peripheral Arterial Disease. Thromb Res. 2010;126:350-2 pubmed publisher
    Conversion of fibrinogen to fibrin plays an essential role in hemostasis and results in stabilization of the fibrin clot...
  83. Smith N, Huffman J, Strachan D, Huang J, Dehghan A, Trompet S, et al. Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011;123:1864-72 pubmed publisher
    ..7 kb downstream of F5, coagulation factor V. At 4q32, rs13109457 (P=2.9×10(-18)) was located between 2 fibrinogen genes: 10.4 kb downstream from FGG and 3.0 kb upstream from FGA. Variants were associated with a 0.099-, 0...
  84. Alves C, Konstantopoulos K. PDGF suppresses the sulfation of CD44v and potentiates CD44v-mediated binding of colon carcinoma cells to fibrin under flow. PLoS ONE. 2012;7:e41472 pubmed publisher
    ..Collectively, these data offer a novel perspective into the mechanism by which PGDF regulates CD44-dependent binding of metastatic colon carcinoma cells to fibrin(ogen). ..
  85. Westbury S, Duval C, Philippou H, Brown R, Lee K, Murden S, et al. Partial deletion of the ?C-domain in the Fibrinogen Perth variant is associated with thrombosis, increased clot strength and delayed fibrinolysis. Thromb Haemost. 2013;110:1135-44 pubmed publisher
    Genetic fibrinogen (FGN) variants that are associated with bleeding or thrombosis may be informative about fibrin polymerisation, structure and fibrinolysis...
  86. Quinn T, Alghamdi J, Padmanabhan S, Porteous D, Smith B, Hocking L, et al. Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age (Dordr). 2015;37:9820 pubmed publisher
    ..Our chosen blood factors and associated polymorphisms were D-dimer [rs12029080], fibrinogen [rs1800789], plasminogen activator inhibitor [rs2227631], and von Willebrand factor [rs1063857]...
  87. Zhang J, Nancy Xiaonan Y, Zhang J, Zhou M. Age stereotypes, flexible goal adjustment, and well-being among Chinese older adults. Psychol Health Med. 2018;23:210-215 pubmed publisher
    ..Tailored interventions to modify aging perceptions and to enhance coping flexibility competence might be helpful for promoting the well-being of older adults. ..
  88. Watt K, Cottrell B, Strong D, Doolittle R. Amino acid sequence studies on the alpha chain of human fibrinogen. Overlapping sequences providing the complete sequence. Biochemistry. 1979;18:5410-6 pubmed
    The complete amino acid sequence of the alpha chain of human fibrinogen has been determined. It contains 610 amino acid residues and has a calculated molecular weight of 66,124...
  89. Blomback B, Hessel B, Hogg D. Disulfide bridges in nh2 -terminal part of human fibrinogen. Thromb Res. 1976;8:639-58 pubmed
  90. Koopman J, Haverkate F, Grimbergen J, Egbring R, Lord S. Fibrinogen Marburg: a homozygous case of dysfibrinogenemia, lacking amino acids A alpha 461-610 (Lys 461 AAA-->stop TAA). Blood. 1992;80:1972-9 pubmed
    In the A alpha-chain gene coding for an abnormal fibrinogen (fibrinogen Marburg) we identified a single base substitution (A-->T) that changes the codon A alpha 461 AAA (Lys) to TAA (Stop)...
  91. Maekawa H, Yamazumi K, Muramatsu S, Kaneko M, Hirata H, Takahashi N, et al. Fibrinogen Lima: a homozygous dysfibrinogen with an A alpha-arginine-141 to serine substitution associated with extra N-glycosylation at A alpha-asparagine-139. Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation cataly. J Clin Invest. 1992;90:67-76 pubmed
    An A alpha-arginine-141 to serine substitution has been identified in a homozygous dysfibrinogen, fibrinogen Lima, associated with impaired fibrin polymerization...
  92. Everse S, Spraggon G, Veerapandian L, Doolittle R. Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. Biochemistry. 1999;38:2941-6 pubmed
    ..Additionally, in the absence of the peptide ligand GPRPam, GHRPam binds to the gamma-chain pocket, a new calcium-binding site being formed concomitantly. ..