FHIT

Summary

Gene Symbol: FHIT
Description: fragile histidine triad
Alias: AP3Aase, FRA3B, AP3A hydrolase, bis(5'-adenosyl)-triphosphatase, diadenosine 5',5'''-P1,P3-triphosphate hydrolase, dinucleosidetriphosphatase, tumor suppressor protein
Species: human

Top Publications

  1. ncbi Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase
    L D Barnes
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284 7760, USA
    Biochemistry 35:11529-35. 1996
  2. ncbi The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    M Ohta
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Cell 84:587-97. 1996
  3. pmc Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts
    Min Shi
    Biostatistics Branch, NIEHS NIH, Durham, North Carolina, USA
    Am J Med Genet A 158:784-94. 2012
  4. ncbi Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors
    Ou Wang
    Key laboratory of Endocrine, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    Chin Med J (Engl) 125:2895-901. 2012
  5. ncbi Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells
    Velliyur K Gopalakrishnan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Pancreatology 3:293-302. 2003
  6. pmc Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma
    De Tao Yin
    Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P R China
    Int J Clin Exp Pathol 3:482-91. 2010
  7. ncbi Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma
    De Tao Yin
    Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Ann Clin Lab Sci 40:267-72. 2010
  8. ncbi FHIT promotes the apoptosis of QBC939 by reducing the expression of cyclin D1
    Qiang Huang
    Department of General Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China
    Hepatogastroenterology 58:713-8. 2011
  9. ncbi Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 56:3053-62. 2007
  10. doi Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
    Anne Letessier
    Institut Curie, Centre de Recherche, 26 Rue d Ulm, 75248 Paris, France
    Nature 470:120-3. 2011

Research Grants

Detail Information

Publications220 found, 100 shown here

  1. ncbi Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase
    L D Barnes
    Department of Biochemistry, University of Texas Health Science Center, San Antonio 78284 7760, USA
    Biochemistry 35:11529-35. 1996
    ..histidines are required for full activity, and the central histidine of the triad is absolutely essential for Ap3A hydrolase activity...
  2. ncbi The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers
    M Ohta
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania, USA
    Cell 84:587-97. 1996
    A 200-300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines...
  3. pmc Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts
    Min Shi
    Biostatistics Branch, NIEHS NIH, Durham, North Carolina, USA
    Am J Med Genet A 158:784-94. 2012
    ..Thus, the most promising SNPs identified by this study may still be worth further investigation...
  4. ncbi Expression of Ki-67, galectin-3, fragile histidine triad, and parafibromin in malignant and benign parathyroid tumors
    Ou Wang
    Key laboratory of Endocrine, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
    Chin Med J (Engl) 125:2895-901. 2012
    ..Our study aimed to investigate the differential expression of Ki-67, galectin-3, fragile histidine triad (FHIT) gene, and parafibromin in PC, parathyroid adenoma (PA), parathyroid hyperplasia (PH), and normal parathyroid (NP) ..
  5. ncbi Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells
    Velliyur K Gopalakrishnan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Pancreatology 3:293-302. 2003
    The human FHIT gene is altered or lost in many cancers and FHIT has been shown to be a tumor suppressor. However, the mechanism of tumor suppression by the FHIT gene remains unclear...
  6. pmc Association of the promoter methylation and protein expression of Fragile Histidine Triad (FHIT) gene with the progression of differentiated thyroid carcinoma
    De Tao Yin
    Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P R China
    Int J Clin Exp Pathol 3:482-91. 2010
    The role of aberrant methylation of fragile histidine triad (FHIT) promoters in the differentiated thyroid carcinoma (DTC) is not yet clear...
  7. ncbi Homozygous deletion but not mutation of exons 5 and 8 of the fragile histidine triad (FHIT) gene is associated with features of differentiated thyroid carcinoma
    De Tao Yin
    Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
    Ann Clin Lab Sci 40:267-72. 2010
    The fragile histidine triad (FHIT) gene encompasses the most common human fragile site, FRA3B at 3p14.2, a region that is involved in homozygous deletions in a variety of human tumors...
  8. ncbi FHIT promotes the apoptosis of QBC939 by reducing the expression of cyclin D1
    Qiang Huang
    Department of General Surgery, Affiliated Provincial Hospital of Anhui Medical University, Hefei, China
    Hepatogastroenterology 58:713-8. 2011
    The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene. Recent studies have found that FHIT protein is lost in digestive system neoplasms...
  9. ncbi Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations
    Evadnie Rampersaud
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, 660 West Redwood St, Room 494, Baltimore, MD 21201, USA
    Diabetes 56:3053-62. 2007
    ..We sought to identify type 2 diabetes susceptibility genes through a genome-wide association scan (GWAS) in the Amish...
  10. doi Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
    Anne Letessier
    Institut Curie, Centre de Recherche, 26 Rue d Ulm, 75248 Paris, France
    Nature 470:120-3. 2011
    ..Here we show, in contrast to this view, that the fragility of FRA3B--the most active common fragile site in human lymphocytes--does not rely on fork slowing or stalling but on a ..
  11. doi Pathology and biology associated with the fragile FHIT gene and gene product
    Joshua C Saldivar
    Integrated Biomedical Science Graduate Program, Ohio State University Medical Center, Columbus, Ohio, USA
    J Cell Biochem 109:858-65. 2010
    ..scientific publications after the discovery of the first gene at a chromosome fragile site, the FHIT gene at FRA3B, there are still questions to pursue concerning the selective advantage conferred to cells by loss of expression ..
  12. ncbi Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections
    Francesca Bianchi
    Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Cell Cycle 6:643-6. 2007
    The tumor suppressor gene FHIT is inactivated by genetic and epigenetic changes, i.e., loss of heterozygosity or promoter hypermethylation, in common human cancers...
  13. ncbi Structure and expression of the human FHIT gene in normal and tumor cells
    T Druck
    Department of Microbiology, Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 57:504-12. 1997
    ..2, the FRA3B common fragile region, and homozygous deletions in various cancer-derived cell lines...
  14. pmc Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells
    Francesco Trapasso
    Ohio State University, Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    J Biol Chem 283:13736-44. 2008
    b>Fhit protein is lost in most cancers, its restoration suppresses tumorigenicity, and virus-mediated FHIT gene therapy induces apoptosis and suppresses tumors in preclinical models...
  15. pmc Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis
    Alessandro Rimessi
    Department of Experimental and Diagnostic Medicine, Interdisciplinary Center for the Study of Inflammation, Emilia Romagna Laboratory BioPharmaNet Laboratory, University of Ferrara, 44100 Ferrara, Italy
    Proc Natl Acad Sci U S A 106:12753-8. 2009
    Despite the growing interest in the Fhit tumor suppressor protein, frequently deleted in human cancers, the mechanism of its powerful proapoptotic activity has remained elusive...
  16. pmc Fhit is a physiological target of the protein kinase Src
    Yuri Pekarsky
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 101:3775-9. 2004
    The FHIT gene is a tumor suppressor that is frequently inactivated by genomic alterations at chromosomal region 3p14.2...
  17. pmc FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
    Francesca Bianchi
    Molecular Biology Unit, Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, 20133 Milan, Italy
    Proc Natl Acad Sci U S A 103:18981-6. 2006
    The tumor suppressor gene FHIT is inactivated by genetic and epigenetic changes in the majority of common human cancers...
  18. ncbi The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression
    Luca Roz
    Department of Experimental Oncology, Istituto Nazionale Tumori, Via Venezian 1, Milan 20133, Italy
    Oncogene 23:9102-10. 2004
    The expression of the tumour suppressor protein fragile histidine triad (Fhit) is often impaired in many human cancers and its restoration in Fhit-negative cancer cell lines suppresses tumorigenicity and induces apoptosis...
  19. ncbi FRA3B and other common fragile sites: the weakest links
    K Huebner
    Kimmel Cancer Center, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
    Nat Rev Cancer 1:214-21. 2001
    ..The product of the fragile histidine triad (FHIT) gene, which encompasses this fragile site, is partially or entirely lost in most human cancers, indicating that it ..
  20. ncbi Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors
    Shantel Corbin
    Section of Hematology Oncology, and the Cancer Research Center, The University of Chicago, Illinois 60637, USA
    Cancer Res 62:3477-84. 2002
    The FRA3B, at 3p14.2, lies within the fragile histidine triad (FHIT) gene and is the most highly expressed of the common fragile sites observed when DNA replication is perturbed by aphidicolin...
  21. ncbi Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2
    F V Rassool
    Section of HematologysolidusOncology, The University of Chicago, Chicago, Illinois, 60637, USA
    Genomics 35:109-17. 1996
    ..2, a common fragile site (FRA3B)...
  22. ncbi Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma
    Yoshihiro Kameoka
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Aichi, Japan
    Oncogene 23:9148-54. 2004
    ..All of the deleted regions were located within the fragile histidine triad (FHIT) gene, and the most frequent region of loss was mapped to 0...
  23. ncbi Evidence that instability within the FRA3B region extends four megabases
    Nicole A Becker
    Department of Experimental Pathology, Mayo Foundation, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:8713-22. 2002
    b>FRA3B is the most frequently expressed common fragile site localized within human chromosomal band 3p14.2, which is frequently deleted in many different cancers, including cervical cancer...
  24. ncbi Phosphorylation of the human Fhit tumor suppressor on tyrosine 114 in Escherichia coli and unexpected steady state kinetics of the phosphorylated forms
    Preston N Garrison
    Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Biochemistry 44:6286-92. 2005
    The human tumor suppressor Fhit is a homodimeric histidine triad (HIT) protein of 147 amino acids which has Ap(3)A hydrolase activity...
  25. pmc Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic
    Ayumi Matsuyama
    Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 100:14988-93. 2003
    ..b>FRA3B, located at chromosome region 3p14...
  26. ncbi Down-regulation of fragile histidine triad expression in prostate carcinoma
    Rebecca L Fouts
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 97:1447-52. 2003
    ..The gene encompasses the common human chromosomal fragile site, the FRA3B locus at chromosome 3p14.2, and is expressed in most normal adult tissues and tumor cell lines...
  27. ncbi Correlation of intracellular diadenosine triphosphate (Ap3A) with apoptosis in Fhit-positive HEK293 cells
    David I Fisher
    Cell Regulation and Signalling Group, School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, UK
    Cancer Lett 259:186-91. 2008
    The pro-apoptotic Fhit tumor suppressor protein binds and hydrolyses diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) in vitro...
  28. ncbi Dose-dependent effect of FHIT-inducible expression in Calu-1 lung cancer cell line
    Andrea Cavazzoni
    Department of Experimental Medicine, University of Parma, Via Volturno 39, Parma 43100, Italy
    Oncogene 23:8439-46. 2004
    Abnormalities in the expression of the tumour suppressor fragile histidine triad (FHIT) gene have been reported in a variety of human tumours, including lung cancer and restoration of its expression in cancer cell lines resulted in the ..
  29. ncbi Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans
    Albert M Levin
    Departments of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 16:1294-7. 2007
    ..Encompassing the most active fragile site in the human genome, FRA3B, FHIT has become the model fragile site-associated tumor suppressor gene...
  30. ncbi Distribution of Fhit protein in rat tissues and its intracellular localization
    F Golebiowski
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Mol Cell Biochem 226:49-55. 2001
    ..The way in which Fhit exerts its tumor suppressor activity and the relationship of the Ap3A hydrolase activity to tumor suppression are not known...
  31. ncbi Loss of FHIT protein expression is a marker of adverse evolution in good prognosis localized breast cancer
    Christophe Ginestier
    Département d Oncologie Moléculaire, Institut Paoli Calmettes and U119 Inserm, IFR57, Marseille, France
    Int J Cancer 107:854-62. 2003
    The FHIT tumor suppressor gene, which encompasses the fragile site FRA3B at 3p14.2, is altered frequently in many types of human cancers...
  32. pmc Increased sensitivity to cisplatin in non-small cell lung cancer cell lines after FHIT gene transfer
    F Andriani
    Department of Experimental Oncology, Istituto Nazionale Tumori, Milan, Italy
    Neoplasia 8:9-17. 2006
    To evaluate the relevance of fragile histidine triad (FHIT) status in relation to drug treatment, we analyzed the sensitivity of the Fhit-negative non-small cell lung cancer (NSCLC) cell line NCI-H460 to different drugs, after treatment ..
  33. ncbi Molecular analysis of the FHIT gene in human prostate cancer
    A Latil
    Laboratoire d oncogénétique, Centre Rene Huguenin, St Cloud, France
    Oncogene 16:1863-8. 1998
    A variety of studies suggest that the FHIT gene, which encompasses the fragile site at 3p14.2, is a candidate tumor suppressor gene in several forms of human cancer...
  34. pmc Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit
    H C Pace
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 95:5484-9. 1998
    Alterations in the FHIT gene at 3p14.2 occur as early and frequent events in the development of several common human cancers...
  35. ncbi Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35
    Flavia Pichiorri
    Ohio State University Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    Clin Cancer Res 12:3494-501. 2006
    Expression of the FHIT protein is lost or reduced in most solid tumors and a significant fraction of hematopoietic malignancies...
  36. pmc Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions
    Flavia Pichiorri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University and Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    J Biol Chem 284:1040-9. 2009
    We have previously shown that Fhit tumor suppressor protein interacts with Hsp60 chaperone machinery and ferredoxin reductase (Fdxr) protein...
  37. pmc Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9
    Y Shi
    Department of Biological and Medical Research MBC 03, King Faisal Specialist Hospital and Research Center, P O Box 3354, Riyadh 11211, Saudi Arabia
    Biochem J 352:443-8. 2000
    b>FHIT (fragile histidine triad), a candidate tumour suppressor gene, has recently been identified at chromosomal region 3p14.2, and deletions of the gene have been reported in many types of human cancer...
  38. ncbi Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells
    Masahiko Nishizaki
    Department of Thoracic and Cardiovascular Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:5745-52. 2004
    Aberrations of the tumor suppressor genes FHIT and p53 are frequently associated with a wide range of human cancers, including lung cancer...
  39. pmc Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma
    H Andachi
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Br J Cancer 87:441-5. 2002
    The Fragile Histidine Triad gene, encompassing the FRA3B fragile site at chromosome 3p14.2, is a candidate tumour suppressor gene involved in multiple tumour types including colorectal carcinomas...
  40. pmc Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 78:73-8. 1998
    ..We have examined the status of p53 and K-ras genes and the presence of loss of heterozygosity (LOH) at the FHIT locus in a series of 35 lung adenocarcinomas that developed in subjects who had never smoked...
  41. ncbi Use of monoclonal antibodies in the functional characterization of the Saccharomyces cerevisiae Sep1 protein
    A Holler
    Institute of General Microbiology, University of Bern, Switzerland
    Eur J Biochem 231:329-36. 1995
    ..The implications of these data for the interpretation of proteins which promote homologous pairing of DNA are discussed, in particular in light of the reannealing activity of the p53 human tumor-suppressor protein...
  42. ncbi Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Curr Gene Ther 4:53-63. 2004
    ..identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2...
  43. ncbi p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation
    T Cutilli
    Maxillofacial Institute Surgical Department, University of L Aquila, Italy
    J Chemother 10:411-7. 1998
    The authors carried out immunohistochemical and genetic research on the tumor suppressor protein p53 and H-RAS oncogene in oromaxillofacial neoplasms...
  44. ncbi High-risk human papillomavirus, tumor suppressor protein p53 and mitomycin-C in invasive squamous cell carcinoma cervix
    S Rajaram
    Department of Obstetrics and Gynaecology, Guru Teg Bahadur Hospital, University College of Medical Sciences, Delhi 110 095, India
    Indian J Cancer 43:156-62. 2006
    ..Clinical data relating to human papillomavirus (HPV) infection and p53 status in cervical cancer has been sparse and confusing...
  45. ncbi Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA
    Raphael Stoll
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Biol 372:1227-45. 2007
    The zinc finger domain of the Wilms tumor suppressor protein (WT1) contains four canonical Cys(2)His(2) zinc fingers. WT1 binds preferentially to DNA sequences that are closely related to the EGR-1 consensus site...
  46. ncbi Common fragile sites, extremely large genes, neural development and cancer
    David I Smith
    Co head of the Ovarian Cancer Program, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Rochester, MN 55905, USA
    Cancer Lett 232:48-57. 2006
    ..The first CFS to be cloned and characterized was FRA3B, the most active CFS in the human genome. Instability within this region extends for over 4...
  47. doi Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland
    Nazmiye Dincer
    Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey
    Oral Oncol 46:195-9. 2010
    ..FHIT and WWOX are tumor suppressor genes that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3, respectively...
  48. ncbi RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells
    Javier A Menendez
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Int J Mol Med 15:33-40. 2005
    ....
  49. doi Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH)
    E Guidi
    Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Pavia, Italy
    Cytogenet Genome Res 120:173-7. 2008
    ..gene is a tumor suppressor gene known to be inactivated in many tumors including bladder tumors and is spanning FRA3B, a very active common fragile site in the human genome...
  50. ncbi Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells
    Kerstin Herzer
    I Medical Department, , Mainz, Germany
    Cancer Res 65:10830-7. 2005
    b>Tumor suppressor protein promyelocytic leukemia (PML) is implicated in apoptosis regulation and antiviral response...
  51. ncbi Protein phosphatase type 1-dependent dephosphorylation of the retinoblastoma tumor suppressor protein in ultraviolet-irradiated human skin and keratinocytes
    M J Edwards
    University of Wales Institute Cardiff, School of Applied Sciences, Llandaff Campus, Western Avenue, Cardiff, U K
    J Invest Dermatol 115:88-94. 2000
    ..serine/threonine phosphatase in the ultraviolet radiation-induced dephosphorylation of retinoblastoma tumor suppressor protein in human skin and cultured keratinocytes...
  52. pmc Loss of FHIT expression in transitional cell carcinoma of the urinary bladder
    R Baffa
    Department of Urology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 156:419-24. 2000
    ..We recently cloned the tumor suppressor gene FHIT (fragile histidine triad) at 3p14...
  53. ncbi FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia
    F S Liu
    Division of Gynecologic Oncology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Gynecol Oncol 82:283-90. 2001
    Recently a candidate tumor suppressor gene, FHIT (fragile histidine triad), was identified at chromosome 3p14.2. Abnormality of this gene has been observed in a variety of human tumors...
  54. pmc Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands
    H Nagel
    Department of Cytopathology, Georg August University of Gottingen, Robert Koch Straszligbeta e 40, D 37075 Gottingen, Germany
    Mol Pathol 56:226-31. 2003
    ..This study aimed to analyse the expression of putative tumour suppressor genes, FHIT and WT-1, and tumour rejection genes, BAGE, GAGE-1/2, MAGE-1, MAGE-3, and HAGE (which are reported to be important ..
  55. ncbi High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, 612 65 Brno, Czech Republic
    Biochemistry 43:7215-25. 2004
    ..Only the full-length p53 can form stable ternary complexes with hcDNA and HMGB1. The possible biological relevance of p53 and HMGB1 binding to hemicatenanes is discussed...
  56. ncbi An FHIT tumor suppressor gene?
    M M Le Beau
    Section of Hematology Oncology, University of Chicago, Illinois 60637, USA
    Genes Chromosomes Cancer 21:281-9. 1998
    The FRA3B at 3p14.2 is the most common of the constitutive aphidicolin-inducible fragile sites. Using independent approaches, four groups of investigators have cloned and characterized this fragile site...
  57. ncbi Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinoma
    Keith M Kerr
    Department of Pathology, Aberdeen University Medical School, Aberdeen, UK
    J Pathol 203:638-44. 2004
    ..We examined the expression of the putative tumour suppressor gene product Fhit, cell adhesion molecules CD44v6, E-cadherin and beta-catenin, and matrix metalloproteinase 2 and its inhibitor, ..
  58. ncbi Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats
    Toshifumi Tsujiuchi
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Nara, Japan
    Mol Carcinog 34:19-24. 2002
    The present study was conducted to assess whether Fhit gene alterations are a feature of hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) in male Fischer 344 rats...
  59. ncbi Loss of FHIT expression in breast cancer is correlated with poor prognostic markers
    Banu Arun
    Division of Hematology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard 424, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1681-5. 2005
    The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene that is thought to be involved in the carcinogenesis of breast cancer...
  60. ncbi Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 20:87-94. 2005
    ..to address whether homozygous deletion (HZD) or transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCC).
  61. ncbi [Expression of nuclear factor-kappa-B/P65 and fragile histidine triad in colorectal carcinoma and clinical significance thereof]
    Yang Lu
    Department of Pathology, General Hospital of Chinese People s Liberation Army, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 88:610-4. 2008
    To investigate the expression of nuclear factor-kappa-B (NF-KB)/P65 and fragile histidine triad (FHIT) in colorectal carcinoma and clinical significance thereof.
  62. ncbi Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer
    RuiYun Li
    Department of Surgery, The University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
    Clin Cancer Res 13:482-7. 2007
    ..The aim of this study was to determine whether the genetic changes can be used as markers in sputum specimen for the early detection of lung cancer...
  63. ncbi Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression
    Shuho Semba
    Comprehensive Cancer Center and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Room 455C, Wiseman Hall, 410 West 12th Avenue, Columbus, 43210, USA
    Mol Cancer Res 4:529-38. 2006
    Loss of fragile histidine triad (Fhit) expression is often associated with human malignancies, and Fhit functions as a tumor suppressor in controlling cell growth and apoptosis, although specific signal pathways are still undefined...
  64. pmc Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles
    Cristina Uboldi
    Department of Genetics and Microbiology A, Buzzati Traverso, University of Pavia, Italy
    BMC Genomics 7:123. 2006
    ..FHIT is frequently hit by deletions caused by fragility at FRA3B, the most active of human common fragile sites, where FHIT lays...
  65. ncbi [Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
    Cheng Cai Yao
    Department of Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, 430071, PR China
    Ai Zheng 23:310-6. 2004
    Frequent loss of fragile histidine triad (FHIT) expression in human gastrointestinal tract carcinomas has been reported; however, there were divergent opinions regarding FHIT expression in colorectal carcinoma...
  66. doi Allelic imbalance and abnormal expression of FHIT in endemic nasopharyngeal carcinoma: association with clinicopathological features
    Yan Fei Deng
    Department of Otolaryngology, Zhongshan Hospital, Xiamen University, 209 Hubin South Road, Xiamen, Fujian, 361004, People s Republic of China
    Eur Arch Otorhinolaryngol 267:1933-41. 2010
    The FHIT gene is involved in the pathogenesis of many cancers...
  67. ncbi Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type
    C Y Muller
    Department of Obstetrics and Gynecology, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    J Natl Cancer Inst 90:433-9. 1998
    Chromosome 3p14.2 contains FRA3B, the most active chromosome breakage site in the human genome. The fragile histidine triad (FHIT) gene, a putative tumor suppressor gene, overlaps FRA3B...
  68. ncbi Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
    H Okuda
    Department of Urology, Kochi Medical School, Kochi, 783 8505, Japan
    Biochem Biophys Res Commun 263:491-7. 1999
    VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggested to be involved in ubiquitin-mediated protein degradation...
  69. ncbi Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency
    Nicola Zanesi
    Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:6576-82. 2005
    The FHIT gene plays important roles in cancer development, including lung cancers, in which the Fhit protein is frequently lost...
  70. pmc A novel approach to simultaneously scan genes at fragile sites
    Pascale Willem
    Department of Hematology and Molecular Medicine University of the Witwatersrand and the National Health Laboratory Services, Wits Medical School, 8 York road, 2193 Parktown, South Africa
    BMC Cancer 6:205. 2006
    ..The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively...
  71. ncbi Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines
    Hiroko Hiraoka
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 71:769-77. 2009
    The fragile histidine triad (FHIT) gene is a tumor-associated gene, and aberrant FHIT gene and protein expression have been described in many types of human tumors...
  72. ncbi Hsp90 chaperones wild-type p53 tumor suppressor protein
    Dawid Walerych
    International Institute of Molecular and Cell Biology in Warsaw, 02 109 Warsaw, Poland
    J Biol Chem 279:48836-45. 2004
    ..used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 ..
  73. ncbi The FHIT gene in oral squamous cell carcinoma: allelic imbalance is frequent but cDNA aberrations are uncommon
    S Pateromichelakis
    Department of Oral and Maxillofacial Surgery Molecular Oncology, Guy s, King s and St Thomas School of Dentistry, Caldecot Road, London, UK
    Oral Oncol 36:180-8. 2000
    The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein...
  74. pmc Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine
    Roumen Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 103:7823-8. 2006
    The FHIT gene has many hallmarks of a tumor-suppressor gene and is involved in a large variety of cancers...
  75. ncbi Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors
    J Louhelainen
    ICRF Cancer Medicine Research Unit, Cancer Research Building, St James s University Hospital, Leeds LS9 7TF, UK
    Int J Oncol 18:203-10. 2001
    ..The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FHIT) gene (3p14.2; D3S1300), which is a candidate tumor suppressor gene for many cancer types...
  76. ncbi Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes
    J D Wade
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    J Pept Res 58:204-12. 2001
    ..tumors stem from mutations in the gene coding for the production of the adenomatous polyposis coli (APC) tumor suppressor protein. This protein contains a coiled-coil N-terminal domain that is known to be responsible for ..
  77. ncbi FHIT mRNA expression in thymoma
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Eur J Surg Oncol 29:904-7. 2003
    The FHIT gene is located at 3p14.2 a region frequently lost in multiple tumour types. Loss of FHIT expression has been found to occur frequently in multiple tumour types...
  78. pmc Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10852-60. 2002
    ..hydrolases and nucleotide transferases consists of a branch of proteins related to Hint and Aprataxin, a branch of Fhit-related hydrolases, and a branch of galactose-1-phosphate uridylyltransferase (GalT)-related transferases...
  79. ncbi DNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area
    X Q Guo
    Department of Endoscopy, The 4th Affiliated Hospital, Hebei Medical University, China
    J Exp Clin Cancer Res 26:587-94. 2007
    ..The purpose of this study was to investigate aberrant promoter methylation of the p16 and FHIT genes in tissues and plasma and loss of protein expression in esophageal precancerous conditions (EPC) and ..
  80. pmc A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions
    Jack Y Yang
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Genomics 9:S23. 2008
    ..as hTERT, PCNA and Ki-67 can be considered as cancer markers, while another set of antigens such as P27KIP1 and FHIT are possible markers for normal tissue...
  81. ncbi FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    J Pathol 184:240-6. 1998
    ..of 51 BACs, previously investigated for K-ras gene mutations, has evaluated the status of two other genes, p53 and FHIT, known to be frequently altered in non-small cell lung cancer...
  82. ncbi The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region
    T W Glover
    Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor 48109, USA
    Cancer Res 58:3409-14. 1998
    ..exhibits both genomic deletions and aberrant transcripts in a variety of tumors and spans the common fragile site FRA3B. This fragile site extends over a broad region of several hundred kb within the FHIT gene and may account for its ..
  83. pmc Impaired replication dynamics at the FRA3B common fragile site
    Aparna Palakodeti
    Department of Medicine, Section of Hematology Oncology, The University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 19:99-110. 2010
    ..replication stress, we examined replication dynamics within a 50 kb region of the most frequently expressed CFS, FRA3B. We mapped four origins of replication, ori 1-4, using two independent methods...
  84. ncbi p53 and FHIT mutations and microsatellite alterations in malignancy-associated pleural effusion
    Jin Hwa Lee
    Department of Internal Medicine, Medical Research Center, Ewha Womans University Mokdong Hospital, 911 1 Mokdong Yangcheon gu, Seoul 158 710, South Korea
    Lung Cancer 44:33-42. 2004
    ..whether the genetic analysis of pleural fluid can be used to diagnose malignant effusion, we investigated p53 and FHIT mutations and microsatellite alterations (MA) in the pleural fluid of 40 patients with pleural effusion associated ..
  85. pmc Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic haemopoietic cells
    M Carapeti
    Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Br J Cancer 78:601-5. 1998
    Deletions and apparent transcriptional abnormalities of the FHIT gene at 3p14.2 have recently been reported in a wide variety of solid tumours...
  86. ncbi Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer
    Isabella Sbrana
    Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy
    Genes Chromosomes Cancer 45:429-36. 2006
    ..This appears to be the case for FRA3B and FRA16D, localized in two tumor-suppressor genes (FHIT and WWOX, respectively) that are altered by deletions or ..
  87. ncbi The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1
    Kurt A Krummel
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 34:154-67. 2002
    ..CFSs) have been cloned and characterized, including the two most frequently observed in the human population, FRA3B and FRA16D...
  88. pmc Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit
    T Shiraishi
    Kimmel Cancer Center, Jefferson Medical College, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:5722-7. 2001
    ..This study describes a comparison of orthologous fragile regions, the human FRA3B/FHIT and the murine Fra14A2/Fhit locus...
  89. ncbi Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
    Martin F Arlt
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genes Chromosomes Cancer 33:82-92. 2002
    The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated FHIT gene...
  90. doi Fragile histidine triad protein: structure, function, and its association with tumorogenesis
    Md Imtaiyaz Hassan
    Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India
    J Cancer Res Clin Oncol 136:333-50. 2010
    The human fragile histidine triad (FHIT) gene is a putative tumor suppressor gene, which is located at chromosome region 3p14.2...
  91. ncbi [Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma]
    Po Zhao
    Department of Pathology, General Hospital of Chinese People s Liberation Army, Beijing 100853, China
    Zhonghua Bing Li Xue Za Zhi 35:289-91. 2006
    To study the expression of FHIT protein and its potential application in diagnosing classic Hodgkin lymphoma.
  92. ncbi The von Hippel-Lindau tumor suppressor protein
    M Ivan
    Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Womens Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 11:27-34. 2001
    The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor)...
  93. ncbi A Fhit-ing role in the DNA damage checkpoint response
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
    Cell Cycle 6:1044-8. 2007
    ..Finally, results of a recent study have suggested that the DNA damage-susceptible FRA3B/FHIT chromosome fragile region, paradoxically, encodes a protein, Fhit, that is necessary for protecting cells ..
  94. doi DNA methylation profile in diffuse type gastric cancer: evidence for hypermethylation of the BRCA1 promoter region in early-onset gastric carcinogenesis
    Carolina Bernal
    Departmento Anatomía Patológica, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Biol Res 41:303-15. 2008
    ..The most frequent methylated genes were FHIT, E-cadherin, BRCA1 and APC (>50%), followed by p14, p16, p15, p73, MGMT and SEMA3B (20-49%)...
  95. doi Apoptotic markers in a prostate cancer cell line: effect of ellagic acid
    Luca Vanella
    Department of Drug Science, Section of Biochemistry, University of Catania, I 95125 Catania, Italy
    Oncol Rep 30:2804-10. 2013
    ..EA treatment resulted in the increased expression of the tumor suppressor protein p21 and increased the percentage of apoptotic cells...
  96. pmc Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins
    Hiren Banerjee
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry New Jersey Medical School, Newark, New Jersey 07103, USA
    RNA 15:1554-64. 2009
    A new member of the FHIT protein family, designated HIT-45, has been identified in the African trypanosome Trypanosoma brucei...
  97. doi GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1α destabilization
    Qian Liu
    Department of Histology and Embryology, Key Laboratory of the Ministry of Education for Experimental Teratology, Shandong University School of Medicine, Jinan, Shandong, China
    Carcinogenesis 34:1728-36. 2013
    ..associated with retinoid-interferon-induced mortality-19 (GRIM-19), which was previously identified as a tumor suppressor protein associated with growth inhibition and cell apoptosis, contributes to the switch between oxidative and ..
  98. pmc The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein
    Hiroaki Iwasa
    From the Department of Medical Biochemistry and
    J Biol Chem 288:30320-9. 2013
    ..Together with the previous reports regarding RASSF1A and RASSF3, the stabilization of p53 may be the common function of the C-terminal RASSF proteins. ..
  99. doi Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study
    Brian Weiss
    Division of Oncology, Cincinnati Children s Hospital Medical Center, Cancer and Blood Diseases Institute, Cincinnati, Ohio B W, J P Division of Genetics, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio E S Division of Clinical Pharmacology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio A V National Cancer Institute, Pediatric Oncology Branch, Bethesda, Maryland B C W, E D, P W Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama B K Department of Preventitive Medicine, University of Alabama at Birmingham, Birmingham, Alabama A C Department of Neurology, Boston Children s Hospital, Boston, Massachusetts N U Department of Neurology, Washington University, St Louis, Missouri D H G Children s National Health System, Center for Neuroscience and Behavioral Medicine, Washington, DC R J P Division of Oncology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania M J F Division of Genetics, Primary Children s Hospital, Salt Lake City, Utah D V Division of Neurology, The University of Chicago Medicine Comer Children s Hospital, Chicago, British Columbia
    Neuro Oncol 17:596-603. 2015
    ..Converging evidence has demonstrated that the NF1 tumor suppressor protein, neurofibromin, negatively regulates activity in the mammalian Target of Rapamycin pathway.
  100. doi Enlightened protein: Fhit tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction
    Joanna Zawacka-Pankau
    Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80 822 Gdansk, Poland
    Toxicol Appl Pharmacol 241:246-52. 2009
    The Fhit tumor suppressor protein possesses Ap(3)A (diadenosine triphosphate - ApppA) hydrolytic activity in vitro and its gene is found inactive in many pre-malignant states due to gene inactivation...
  101. doi Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells
    Wayne Chris Hawkes
    USDA Agricultural Research Service, Western Human Nutrition Research Center, University of California at Davis, Davis, California 95616, USA
    J Cell Biochem 113:61-9. 2012
    ..b>Tumor suppressor protein p53 is a master regulator of cell cycle progression and is the most frequently mutated gene in human ..

Research Grants73

  1. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..tumor suppressor genes involved in renal carcinogenesis is tuberous sclerosis gene (TSC2), which encodes tumor suppressor protein, tuberin. Eker rats harboring mutations in TSC2 develop spontaneous renal tumors at a very high incidence...
  2. Biology of the Myb-MuvB Oncoprotein Tumor Suppressor Protein Complex
    JOSEPH STEVEN LIPSICK; Fiscal Year: 2013
    ..A better understanding of the precise structures that mediate this interaction may lead to the development of new small molecules that will be useful in the treatment of breast cancers with increased levels of B-Myb. ..
  3. Regulation of tumorigenic spliced isoforms in cancer
    Aixa Tapia Santos; Fiscal Year: 2010
    ..The Murine Double Minute 2 (MDM2) protein negatively regulates the tumor suppressor protein p53 and its over expression results in transformation of cells...
  4. Mechanism of Dnmt1 Up-regulation by Fhit Loss
    CHARLES M BRENNER; Fiscal Year: 2012
    ..Whereas the FHIT gene has been defined as a gene that causes programmed cell death when reintroduced to cancer cells, normal ..
  5. Role of MDM2 in Cell Proliferation and Tumorigenesis
    Zhi Xiong Jim Xiao; Fiscal Year: 2010
    ..Specific Aim 2 is to investigate the roles of MDMx and tumor suppressor protein ARF in modulation of MDM2-Rb and Specific aim 3 is to examine the role of MDM2-Rb in tumorigenesis in ..
  6. EARLY DETECTION OF URINARY BLADDER CANCER
    Bogdan Czerniak; Fiscal Year: 2009
    ..chromosomal segregation and centrosome function and more recently to be capable of destabilizing the p53 tumor suppressor protein. In this grant we propose the following major groups of studies: (1) Perform functional analyses and ..
  7. Cell-cell adhesion and signal transduction
    Valeri Vasioukhin; Fiscal Year: 2012
    ..Despite these phenotypic correlations, it is still unclear whether 1E- catenin is a tumor suppressor protein. In this application we propose to determine potential tumor-suppressor role of 1E-catenin using stem ..
  8. FOXO1 Inhibition in Genotoxic Stress Response and Prostate Cancer Survival
    Haojie Huang; Fiscal Year: 2013
    ..of the forkhead transcription factor FOXO1 induces apoptosis in PCa cells, suggesting that FOXO1 is a tumor suppressor protein. This notion is further supported by recent findings from our laboratory, as well as our colleagues',..
  9. Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor Suppression
    Peiqing Sun; Fiscal Year: 2012
    ..ras-induced senescence and tumor suppression both in vitro and in vivo, and that PRAK is likely to be a tumor suppressor protein. Our preliminary data reveal that PRAK directly interacts with a multifunctional histone ..
  10. HYPOXIA AND GENE REPRESSION
    Amato J Giaccia; Fiscal Year: 2013
    ..The tumor suppressor protein p53 induces rapid apoptosis in response to oxygen concentrations that induce an S-phase arrest...
  11. Epigenetic Regulation of Epstein-Barr Virus Latency Programs
    Paul M Lieberman; Fiscal Year: 2013
    ..We focus on the control of the major latency promoters Cp and Qp, and how they are regulated by the tumor suppressor protein Rb (aim1), the viral- encoded origin binding protein EBNA1 (aim 2), and the chromatin boundary factor ..
  12. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The most essential human tumor suppressor protein p53 is mutated in more than 50% of the human cancers...
  13. p53 Acetylation as a Mechanism in Chemoprevention by Aspirin
    JAYARAMA B GUNAJE; Fiscal Year: 2010
    ..studies, we have obtained the first and strong evidence for a dose- and time-dependent acetylation of p53 tumor suppressor protein by aspirin in MDA-MB-231 human breast cancer cells, several cancer cells belonging to different tumor ..
  14. TERMINAL DIFFERENTIATION OF THE RENAL EPITHELIUM
    Samir S El-Dahr; Fiscal Year: 2012
    ..The tumor suppressor protein, p53, is a member of a family of transcription factors that regulate cellular growth, differentiation, ..
  15. Indolecarbinol target proteins and anti-cancer signaling in human melanoma cells
    Gary L Firestone; Fiscal Year: 2013
    ..that I3C induces a G1 cell cycle arrest and inhibits cell survival signaling by stabilizing the PTEN tumor suppressor protein levels, which through its dual lipid/protein phosphatase activity then disrupts the Akt signaling network ..
  16. PROPERTIES AND REGULATION OF P53 IN TUMOR CELLS
    Carol Prives; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor protein is likely the most well studied mammalian transcription factor...
  17. Regulation of p53 Transcription by Viral Oncoproteins &Covalent Modifications
    Cheng Ming Chiang; Fiscal Year: 2012
    p53 is a tumor suppressor protein that functions as a cellular genome guardian. Under normal growth conditions, p53 is kept at low levels due to a fast protein turnover rate...
  18. Mechanisms of Mitotic Recombination
    JEFF JOSEPH SEKELSKY; Fiscal Year: 2013
    ..our understanding of mechanisms through which mitotic crossovers are generated and how cells employ the tumor suppressor protein BLM and other proteins to prevent mitotic crossing over, and how putative Holliday junction resolvases ..
  19. Polyoma Virus Disrupts ARF Signaling to p53
    Michael Fried; Fiscal Year: 2011
    ..by applicant): Unscheduled growth signals stimulated by a number of activated oncogenes induce the ARF tumor suppressor protein. ARF can activate a p53 response resulting in cell cycle arrest or apoptotic cell death...
  20. p53-Regulation in Liver Regeneration
    MICHELLE ANN BARTON; Fiscal Year: 2012
    ..We hypothesize that critical functions of the p53 tumor suppressor protein, in promoting cell cycle arrest and apoptosis, must be blocked or attenuated in response to partial ..
  21. CELL CYCLE CHECKPOINT CONTROL IN RESPONSE TO DNA DAMAGE
    Nancy C Walworth; Fiscal Year: 2011
    ..domain homology with mammalian RbBP2, a protein identified by virtue of its ability to bind the tumor suppressor protein Rb and with PLU-1, the product of a gene that is up regulated in breast cancer cells...
  22. Alcohol and PAH-induced carcinogenesis
    Jagat J Mukherjee; Fiscal Year: 2013
    ..Previously we observed accumulation of p53 tumor suppressor protein and G1->S cell cycle arrest as well as cell transformation in response to BPDE treatment of JB6 cells...
  23. Transcriptional regulation of apoptosis
    James J Manfredi; Fiscal Year: 2013
    ..Depending upon particular cellular conditions, the tumor suppressor protein p53 induces growth arrest or mediates an apoptotic response...
  24. ROLE OF CELL CYCLE PROTEINS IN HIV ENCEPHALITIS
    KELLY L JORDANSCIUTTO; Fiscal Year: 2013
    ..Activity of the E2F family is repressed by direct interaction with the Retinoblastoma tumor suppressor protein, pRb, and its family members, an interaction that is disrupted when pRb is hyperphosphorylated...
  25. The Role of RB Family Proteins in an S Phase-Dependent Erythroid Commitment Step
    Merav Socolovsky; Fiscal Year: 2013
    ..1 and S phase progression. Here we propose that the tumor suppressor protein pRb, and its family members, p107 and p130, mediate the antagonistic interactions between PU...
  26. FHIT Gene Therapy in Cancer Prevention and Treatment
    Carlo M Croce; Fiscal Year: 2011
    b>FHIT Gene Therapy in Cancer Prevention and Treatment. We have developed murine upper digestive tract cancer models induced by oral /V-nitrosomethylbenzylamine(NMBA) or 4-nitroquinoline 1-oxide (NQO) treatment...
  27. Reactivation of the p53-mediated pro-Apoptotic Pathway Using Stapled Peptides
    Federico Bernal; Fiscal Year: 2009
    ..Among these, the BCL-2 family of pro- and anti-apoptotic proteins, as well as the p53 tumor suppressor protein, stand out due to their essential roles in triggering apoptosis and cell cycle arrest in response to ..
  28. Transcriptional dynamics and cellular function of p53 pulses
    Jeremy Purvis; Fiscal Year: 2012
    ..When DNA damage occurs, the tumor suppressor protein p53 orchestrates a complex network of signaling pathways that either halts progression through the cell ..
  29. Functional analysis of a putative ATM/ATR substrate RFWD3
    Yi Wang; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The tumor suppressor protein p53 is a key regulator of cell cycle arrest, apoptosis and genomic stability. Mutations of p53 that compromise its function occur in 50% of human cancers...
  30. SOMATIC CELL CYCLE REGULATION BY PHOSPHORYLATION
    TONY R HUNTER; Fiscal Year: 2013
    ..We will study the function of the CtIP tumor suppressor protein, conserved in all eukaryotes...
  31. The Function of RASSF1A in T Cells
    JOANNE PRATT; Fiscal Year: 2009
    ..Several lines of evidence have established a role for Ras association family (RASSF) member RASSF1A as a tumor suppressor protein. (1) RASSF1A has been shown to play a key role in tumor necrosis factor-1 (TNF1) induced programmed cell ..
  32. Mechanisms of Mitotic Recombination
    JEFF JOSEPH SEKELSKY; Fiscal Year: 2010
    ..These studies will enhance our understanding of mechanisms of mitotic crossing over and the role that the important tumor suppressor protein BLM plays in preventing mitotic crossing over.
  33. DNA Recombinational Repair: Role of the p53 Tumor Suppressor Protein
    Simon N Powell; Fiscal Year: 2010
    ....
  34. RNA localization and tumor suppression by APC
    Stavroula Mili; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Loss of the tumor suppressor protein APC is the main cause of colorectal cancer. APC has a well-known role in regulating the transcription factor beta-catenin...
  35. Cell Polarity in Self-renewal and Differentiation of Stem/Progenitor Cells
    Valeri Vasioukhin; Fiscal Year: 2012
    ..Knowledge obtained during this study will help to develop new therapies for treatment of tissue injury, degenerative diseases and cancer. ..
  36. Role of BRCA1 and its association protein CtlP in DNA double-strand break repair
    Xiaohua Wu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The breast cancer tumor suppressor protein BRCA1 participates in multiple aspects of DNA damage responses...
  37. A Functional Census of p53 Cancer and Suppressor Mutants
    Richard H Lathrop; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The transcription factor p53 is a central tumor suppressor protein that controls DNA repair, cell cycle arrest, and apoptosis...
  38. The Combinatorial Effect of p53 Dynamics and Modifications on Cell Fate Decisions
    Sheng Hong Chen; Fiscal Year: 2013
    ..The tumor suppressor protein p53 responds to a wide variety of stresses including DNA damage, hypoxia and hormonal signaling to ..
  39. Modulation of p53 induction by targeting cap-dependent translation in cancer
    Da Qing Yang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The p53 tumor suppressor protein protects cells against malignant transformation through induction of either cell cycle arrest or apoptosis...
  40. The role of a novel BRCA1 associated complex in DNA damage response and tumor sup
    Bin Wang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The hereditary breast and ovarian tumor suppressor protein BRCA1 plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability...
  41. Role of Estrogen Receptor alpha-p53 Interaction in Resistance to Tamoxifen Therap
    Swati Kulkarni; Fiscal Year: 2010
    ..ER mediates effects of estrogen in promoting proliferation of breast cancer cells. Tumor suppressor protein p53 guards against tumorigenesis by mediating cell cycle arrest and/or apoptosis in response to various ..
  42. Modeling The Etiology of P53 Mutated Cancer Cells
    Carl G Maki; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inactivation of the p53 tumor suppressor protein is considered essential for the development of most or all human cancers. Over 50% of cancers harbor TP53 mutations that destroy p53 function...
  43. FHIT GENE ALTERATIONS IN CERVICAL CANCER PATHOGENESIS
    KATHLEEN CHO; Fiscal Year: 2000
    ..Two-color fluorescence in situ hybridization will be used to identify HPV integration in the FRA3B/FHIT locus in primary tumors and cell lines...
  44. MECHANISMS OF GASTROINTESTINAL GROWTH AND TRANSFORMATION
    Juanita L Merchant; Fiscal Year: 2013
    ..funding cycle, we found that the zinc finger transcription factor ZBP-89 interacts directly with the tumor suppressor protein ataxia telangiectasia mutated (ATM) in response to histone deacetylase inhibition (HDACi), e.g...
  45. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..Hence, not too surprising, vinculin exhibits properties of a tumor suppressor protein. The activity of vinculin is controlled by regulating auto-inhibitory or `self'interactions between ..
  46. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El-Dahr; Fiscal Year: 2013
    ..A physiological cross-talk operates between the tumor suppressor protein, p53, and the BdkrB2 during renal organogenesis...
  47. Cytoglobin: A stress-responsive hemoprotein modulating cardiomyocyte survival
    Pradeep P A Mammen; Fiscal Year: 2013
    ..extensive evidence that Cygb is also directly involved in regulating the transcriptional activity of the tumor suppressor protein p53...
  48. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2013
    ..We have shown recently that high glucose- as well as TGF[unreadable]-induced downregulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) contributes to renal cell hypetrophy and ..
  49. Cell Survival and Death in Oxidant Lung Injury
    MICHAEL A O'REILLY; Fiscal Year: 2013
    ..Like hyperoxia, damage to mitochondrial or nuclear DNA stimulated expression of the tumor suppressor protein p53...
  50. Genome maintenance functions of CREB/ATF transcription factors
    RANDAL SCOT TIBBETTS; Fiscal Year: 2013
    ..discovered that CREB is regulated by the ATM (ataxia-telangiectasia-mutated) protein kinase, which is a tumor suppressor protein that functions as master regulator of the DNA damage response (DDR)...
  51. The RAN GTPase
    Ian G Macara; Fiscal Year: 2013
    ..Other interesting targets for methylation by NRMT include the tumor suppressor protein RB. Silencing of NRMT causes mitotic defects...
  52. Mechanism of PCNA Polyubiquitination
    CHRISTOPHER EDWARD BERNDSEN; Fiscal Year: 2010
    ..Ectopic expression of HLTF in colon cancer cells reduced tumor growth suggesting HLTF is a tumor suppressor protein. The functions of HLTF and SHPRH are likely linked to their role in polyubiquitination of PCNA and the ..
  53. Targeting the ARF/CtBP Axis in Pancreatic Cancer
    Steven R Grossman; Fiscal Year: 2010
    ..Pancreatic cancers, which are among the deadliest of human cancers, often lose the function of a key tumor suppressor protein called ARF...
  54. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2012
    ..The tumor suppressor protein LKB1 has recently been identified as an upstream kinase for AMPK and 12 other AMPK-related proteins...
  55. Role of p53 family in neuropathogenesis in AIDS
    Bassel E Sawaya; Fiscal Year: 2012
    ..Recent evidence indicates that the p53 tumor suppressor protein and its related family member, p73, play an essential role in regulating neuronal loss/apoptosis...
  56. RECEPTOR-TARGETED COPPER RADIOPHARMACEUTICALS FOR CANCER IMAGING AND THERAPY
    Carolyn J Anderson; Fiscal Year: 2012
    ..Our second hypothesis is that the tumor suppressor protein p53 is involved in the trafficking of 64Cu to tumor cell nuclei, and this may enhance tumor cell killing (..
  57. Fhit as modulator of Chk1 termination and response to DNA-damaging agents
    JOSHUA SALDIVAR; Fiscal Year: 2012
    ..Loss of expression of the Fhit tumor suppressor protein enhances the ability of cancer cells to survive extensive DNA damage, even the damage caused by ..
  58. REDOX REGULATION OF TUMOR SUPPRESSION BY MNSOD
    Daret K St Clair; Fiscal Year: 2012
    ..found that by modulating the interaction between an essential antioxidant enzyme, MnSOD, and a key tumor suppressor protein, p53, the incidence of skin tumors can be drastically reduced...
  59. Mechansims of Lung Carcinogenesis Induced by Asbestos and Cigarette Smoke
    Deborah E Sullivan; Fiscal Year: 2012
    ..is that cigarette smoke augments the pro-neoplastic effects of asbestos and that inhibition of the p53 tumor suppressor protein enhances inflammation and dysregulates proliferation of BASCs thereby increasing the synergistic effects ..
  60. Caveolin 1: a novel modulator of the PP2A/ATM/p53 pathway
    Ferruccio Galbiati; Fiscal Year: 2013
    ..Premature senescence is believed to contribute to genotoxic stress-induced emphysema. The tumor suppressor protein p53 is a key regulator of premature senescence and is activated by the ataxia-telangiectasia mutated (ATM)..
  61. Development of Small Molecule Crm-1 Inhibitor for Pancreatic Cancer Therapy
    Ramzi M Mohammad; Fiscal Year: 2013
    ..Among the target of CRM-1 is the tumor suppressor protein (TSP) prostate apoptosis response-4 (Par-4)...
  62. Regulation of Skeletal Muscle LKB1
    WILLIAM WINDER; Fiscal Year: 2010
    ..in our laboratory that will enable elucidation of roles and mechanisms of activation and actions of the tumor suppressor protein, LKB1, in skeletal muscle...
  63. REGULATION OF THE P53 TUMOR SUPPRESSOR PROTEIN
    Carol Prives; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Understanding how the p53 tumor suppressor protein works to prevent oncogenesis is a subject of widespread interest...
  64. CHROMOSOME BREAKPOINTS, RENAL & SMALL CELL LUNG CANCER
    David Smith; Fiscal Year: 2000
    DESCRIPTION (Adapted from the Investigator's Abstract): FRA3B, at chromosomal band 3p14.2, is the most active common fragile site in the human genome...
  65. EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICA
    ELLEN RORKE; Fiscal Year: 2002
    ..E6 and E7, that are required for cell immortalization, E6 causes degradation of the cell cycle checkpoint/tumor suppressor protein, p53...
  66. Human Neurotropic JC Virus and CNS Diseases
    Kamel Khalili; Fiscal Year: 2006
    ..lytic cycle and possesses the ability to interact with several important cellular proteins including the tumor suppressor protein, p53, pointing to the oncogenic potential of this virus...
  67. GASTRIC CANCER INDUCED BY H PYLORI IN P27 DEFICIENT MICE
    Steven Moss; Fiscal Year: 2009
    ..pylori decreases gastric epithelial cell p27 protein expression, (ii) p27 has the properties of a tumor suppressor protein, and (iii) low expression of p27 in gastric cancers is associated with poor prognosis...
  68. DEPENDENCE OF P53 ON THIOL MAINTENANCE PROTEINS
    Gary Merrill; Fiscal Year: 2001
    Stimulation of transcription by the human tumor suppressor protein p53 is compromised in yeast lacking the enzyme thioredoxin reductase (Trr1). The result suggests that p53 is prone to oxidative inactivation...
  69. Alteration of Rb in HTLV-1 transformed cells
    Fatah Kashanchi; Fiscal Year: 2005
    ..A significant regulator of the G1 restriction point in eukaryotic cells is the tumor suppressor protein retinoblastoma (Rb)...
  70. EXPRESSION OF MATRIX METALLOPROTEINASE AND P53
    Yubo Sun; Fiscal Year: 2004
    ..My specific research interest is to study the role of tumor suppressor protein and proto-oncogene proteins in the regulation of gene expression of MMPs and TIMPs and in the regulation ..
  71. 12th International p53 Workshop
    Carol Prives; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): The p53 tumor suppressor protein plays pivotal roles in tumor suppression and its gene is the most frequently mutated in human cancers...
  72. Study of a FACTp140-SSRP1-associated p53 Kinase
    Hua Lu; Fiscal Year: 2006
    ..this proposal is to understand the molecular and biochemical basis underlying the regulation of the p53 tumor suppressor protein in mammalian systems...
  73. A High-Throughput Assay for DNA Repair Activity in the Presence of AberrantBRCA1
    JAMES MATTHEW FORD; Fiscal Year: 2010
    ..BRCA1, a 220kD tumor suppressor protein, has been implicated in preventing breast cancer by maintaining genetic stability through its ability to ..