FHIT

Summary

Gene Symbol: FHIT
Description: fragile histidine triad
Alias: AP3Aase, FRA3B, AP3A hydrolase, bis(5'-adenosyl)-triphosphatase, diadenosine 5',5'''-P1,P3-triphosphate hydrolase, dinucleosidetriphosphatase, tumor suppressor protein
Species: human

Top Publications

  1. ncbi Molecular analysis of the FHIT gene in human prostate cancer
    A Latil
    Laboratoire d oncogénétique, Centre Rene Huguenin, St Cloud, France
    Oncogene 16:1863-8. 1998
  2. ncbi Evidence that instability within the FRA3B region extends four megabases
    Nicole A Becker
    Department of Experimental Pathology, Mayo Foundation, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:8713-22. 2002
  3. ncbi Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans
    Albert M Levin
    Departments of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 16:1294-7. 2007
  4. ncbi Down-regulation of fragile histidine triad expression in prostate carcinoma
    Rebecca L Fouts
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 97:1447-52. 2003
  5. ncbi Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 78:73-8. 1998
  6. ncbi Use of monoclonal antibodies in the functional characterization of the Saccharomyces cerevisiae Sep1 protein
    A Holler
    Institute of General Microbiology, University of Bern, Switzerland
    Eur J Biochem 231:329-36. 1995
  7. ncbi Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Curr Gene Ther 4:53-63. 2004
  8. ncbi p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation
    T Cutilli
    Maxillofacial Institute Surgical Department, University of L Aquila, Italy
    J Chemother 10:411-7. 1998
  9. ncbi High-risk human papillomavirus, tumor suppressor protein p53 and mitomycin-C in invasive squamous cell carcinoma cervix
    S Rajaram
    Department of Obstetrics and Gynaecology, Guru Teg Bahadur Hospital, University College of Medical Sciences, Delhi 110 095, India
    Indian J Cancer 43:156-62. 2006
  10. ncbi Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA
    Raphael Stoll
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Biol 372:1227-45. 2007

Research Grants

  1. EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICA
    ELLEN RORKE; Fiscal Year: 2002
  2. Human Neurotropic JC Virus and CNS Diseases
    Kamel Khalili; Fiscal Year: 2006
  3. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El Dahr; Fiscal Year: 2010
  4. DEPENDENCE OF P53 ON THIOL MAINTENANCE PROTEINS
    Gary Merrill; Fiscal Year: 2001
  5. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2010
  6. Alteration of Rb in HTLV-1 transformed cells
    Fatah Kashanchi; Fiscal Year: 2005
  7. EXPRESSION OF MATRIX METALLOPROTEINASE AND P53
    Yubo Sun; Fiscal Year: 2004
  8. 12th International p53 Workshop
    Carol Prives; Fiscal Year: 2006
  9. Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor Suppression
    Peiqing Sun; Fiscal Year: 2010
  10. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    LAURIE GOODYEAR; Fiscal Year: 2009

Detail Information

Publications159 found, 100 shown here

  1. ncbi Molecular analysis of the FHIT gene in human prostate cancer
    A Latil
    Laboratoire d oncogénétique, Centre Rene Huguenin, St Cloud, France
    Oncogene 16:1863-8. 1998
    A variety of studies suggest that the FHIT gene, which encompasses the fragile site at 3p14.2, is a candidate tumor suppressor gene in several forms of human cancer...
  2. ncbi Evidence that instability within the FRA3B region extends four megabases
    Nicole A Becker
    Department of Experimental Pathology, Mayo Foundation, Rochester, Minnesota, MN 55905, USA
    Oncogene 21:8713-22. 2002
    b>FRA3B is the most frequently expressed common fragile site localized within human chromosomal band 3p14.2, which is frequently deleted in many different cancers, including cervical cancer...
  3. ncbi Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans
    Albert M Levin
    Departments of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Cancer Epidemiol Biomarkers Prev 16:1294-7. 2007
    ..Encompassing the most active fragile site in the human genome, FRA3B, FHIT has become the model fragile site-associated tumor suppressor gene...
  4. ncbi Down-regulation of fragile histidine triad expression in prostate carcinoma
    Rebecca L Fouts
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Cancer 97:1447-52. 2003
    ..The gene encompasses the common human chromosomal fragile site, the FRA3B locus at chromosome 3p14.2, and is expressed in most normal adult tissues and tumor cell lines...
  5. ncbi Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    Br J Cancer 78:73-8. 1998
    ..We have examined the status of p53 and K-ras genes and the presence of loss of heterozygosity (LOH) at the FHIT locus in a series of 35 lung adenocarcinomas that developed in subjects who had never smoked...
  6. ncbi Use of monoclonal antibodies in the functional characterization of the Saccharomyces cerevisiae Sep1 protein
    A Holler
    Institute of General Microbiology, University of Bern, Switzerland
    Eur J Biochem 231:329-36. 1995
    ..The implications of these data for the interpretation of proteins which promote homologous pairing of DNA are discussed, in particular in light of the reannealing activity of the p53 human tumor-suppressor protein...
  7. ncbi Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical School, Tochigi 329 0498, Japan
    Curr Gene Ther 4:53-63. 2004
    ..identified by positional cloning of the chromosome region spanning the carcinogen-sensitive, common fragile site, FRA3B at 3p14.2...
  8. ncbi p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation
    T Cutilli
    Maxillofacial Institute Surgical Department, University of L Aquila, Italy
    J Chemother 10:411-7. 1998
    The authors carried out immunohistochemical and genetic research on the tumor suppressor protein p53 and H-RAS oncogene in oromaxillofacial neoplasms...
  9. ncbi High-risk human papillomavirus, tumor suppressor protein p53 and mitomycin-C in invasive squamous cell carcinoma cervix
    S Rajaram
    Department of Obstetrics and Gynaecology, Guru Teg Bahadur Hospital, University College of Medical Sciences, Delhi 110 095, India
    Indian J Cancer 43:156-62. 2006
    ..Clinical data relating to human papillomavirus (HPV) infection and p53 status in cervical cancer has been sparse and confusing...
  10. ncbi Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA
    Raphael Stoll
    Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Mol Biol 372:1227-45. 2007
    The zinc finger domain of the Wilms tumor suppressor protein (WT1) contains four canonical Cys(2)His(2) zinc fingers. WT1 binds preferentially to DNA sequences that are closely related to the EGR-1 consensus site...
  11. ncbi Common fragile sites, extremely large genes, neural development and cancer
    David I Smith
    Co head of the Ovarian Cancer Program, Mayo Clinic Cancer Center, Mayo Clinic College of Medicine, Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Rochester, MN 55905, USA
    Cancer Lett 232:48-57. 2006
    ..The first CFS to be cloned and characterized was FRA3B, the most active CFS in the human genome. Instability within this region extends for over 4...
  12. ncbi Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland
    Nazmiye Dincer
    Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey
    Oral Oncol 46:195-9. 2010
    ..FHIT and WWOX are tumor suppressor genes that encompass the FRA3B and FRA16D fragile sites at chromosomes 3p14.2 and 16q23.3, respectively...
  13. ncbi RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells
    Javier A Menendez
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Int J Mol Med 15:33-40. 2005
    ....
  14. ncbi Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH)
    E Guidi
    Department of Genetics and Microbiology A Buzzati Traverso, University of Pavia, Pavia, Italy
    Cytogenet Genome Res 120:173-7. 2008
    ..gene is a tumor suppressor gene known to be inactivated in many tumors including bladder tumors and is spanning FRA3B, a very active common fragile site in the human genome...
  15. ncbi Hepatitis C virus core protein inhibits tumor suppressor protein promyelocytic leukemia function in human hepatoma cells
    Kerstin Herzer
    I Medical Department, , Mainz, Germany
    Cancer Res 65:10830-7. 2005
    b>Tumor suppressor protein promyelocytic leukemia (PML) is implicated in apoptosis regulation and antiviral response...
  16. ncbi Protein phosphatase type 1-dependent dephosphorylation of the retinoblastoma tumor suppressor protein in ultraviolet-irradiated human skin and keratinocytes
    M J Edwards
    University of Wales Institute Cardiff, School of Applied Sciences, Llandaff Campus, Western Avenue, Cardiff, U K
    J Invest Dermatol 115:88-94. 2000
    ..serine/threonine phosphatase in the ultraviolet radiation-induced dephosphorylation of retinoblastoma tumor suppressor protein in human skin and cultured keratinocytes...
  17. ncbi Loss of FHIT expression in transitional cell carcinoma of the urinary bladder
    R Baffa
    Department of Urology, Kimmel Cancer Center, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Am J Pathol 156:419-24. 2000
    ..We recently cloned the tumor suppressor gene FHIT (fragile histidine triad) at 3p14...
  18. ncbi FHIT (fragile histidine triad) gene analysis in cervical intraepithelial neoplasia
    F S Liu
    Division of Gynecologic Oncology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
    Gynecol Oncol 82:283-90. 2001
    Recently a candidate tumor suppressor gene, FHIT (fragile histidine triad), was identified at chromosome 3p14.2. Abnormality of this gene has been observed in a variety of human tumors...
  19. ncbi Expression of Fhit, cell adhesion molecules and matrix metalloproteinases in atypical adenomatous hyperplasia and pulmonary adenocarcinoma
    Keith M Kerr
    Department of Pathology, Aberdeen University Medical School, Aberdeen, UK
    J Pathol 203:638-44. 2004
    ..We examined the expression of the putative tumour suppressor gene product Fhit, cell adhesion molecules CD44v6, E-cadherin and beta-catenin, and matrix metalloproteinase 2 and its inhibitor, ..
  20. ncbi High-affinity binding of tumor-suppressor protein p53 and HMGB1 to hemicatenated DNA loops
    Michal Stros
    Laboratory of Analysis of Chromosomal Proteins, Academy of Sciences of the Czech Republic, Institute of Biophysics, 612 65 Brno, Czech Republic
    Biochemistry 43:7215-25. 2004
    ..Only the full-length p53 can form stable ternary complexes with hcDNA and HMGB1. The possible biological relevance of p53 and HMGB1 binding to hemicatenanes is discussed...
  21. ncbi Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands
    H Nagel
    Department of Cytopathology, Georg August University of Gottingen, Robert Koch Straszligbeta e 40, D 37075 Gottingen, Germany
    Mol Pathol 56:226-31. 2003
    ..This study aimed to analyse the expression of putative tumour suppressor genes, FHIT and WT-1, and tumour rejection genes, BAGE, GAGE-1/2, MAGE-1, MAGE-3, and HAGE (which are reported to be important ..
  22. ncbi An FHIT tumor suppressor gene?
    M M Le Beau
    Section of Hematology Oncology, University of Chicago, Illinois 60637, USA
    Genes Chromosomes Cancer 21:281-9. 1998
    The FRA3B at 3p14.2 is the most common of the constitutive aphidicolin-inducible fragile sites. Using independent approaches, four groups of investigators have cloned and characterized this fragile site...
  23. ncbi Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats
    Toshifumi Tsujiuchi
    Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashihara, Nara, Japan
    Mol Carcinog 34:19-24. 2002
    The present study was conducted to assess whether Fhit gene alterations are a feature of hepatocellular carcinomas (HCCs) induced by N-nitrosodiethylamine (DEN) in male Fischer 344 rats...
  24. ncbi [Expression of nuclear factor-kappa-B/P65 and fragile histidine triad in colorectal carcinoma and clinical significance thereof]
    Yang Lu
    Department of Pathology, General Hospital of Chinese People s Liberation Army, Beijing 100853, China
    Zhonghua Yi Xue Za Zhi 88:610-4. 2008
    To investigate the expression of nuclear factor-kappa-B (NF-KB)/P65 and fragile histidine triad (FHIT) in colorectal carcinoma and clinical significance thereof.
  25. ncbi Loss of FHIT expression in breast cancer is correlated with poor prognostic markers
    Banu Arun
    Division of Hematology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard 424, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 14:1681-5. 2005
    The fragile histidine triad (FHIT) gene is a putative tumor suppressor gene that is thought to be involved in the carcinogenesis of breast cancer...
  26. ncbi Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 20:87-94. 2005
    ..to address whether homozygous deletion (HZD) or transcriptional alterations of the fragile histidine triad (FHIT) gene play a role in the development and progression of hepatitis C virus-associated hepatocellular carcinoma (HCC).
  27. ncbi Protein expression profiling identifies cyclophilin A as a molecular target in Fhit-mediated tumor suppression
    Shuho Semba
    Comprehensive Cancer Center and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Room 455C, Wiseman Hall, 410 West 12th Avenue, Columbus, 43210, USA
    Mol Cancer Res 4:529-38. 2006
    Loss of fragile histidine triad (Fhit) expression is often associated with human malignancies, and Fhit functions as a tumor suppressor in controlling cell growth and apoptosis, although specific signal pathways are still undefined...
  28. ncbi Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles
    Cristina Uboldi
    Department of Genetics and Microbiology A, Buzzati Traverso, University of Pavia, Italy
    BMC Genomics 7:123. 2006
    ..FHIT is frequently hit by deletions caused by fragility at FRA3B, the most active of human common fragile sites, where FHIT lays...
  29. ncbi [Abnormal expression of fragile histidine triad (FHIT) and Mut S homolog 2 (MSH2) proteins in human sporadic colorectal carcinoma and their clinical significance]
    Cheng Cai Yao
    Department of Oncology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, 430071, PR China
    Ai Zheng 23:310-6. 2004
    Frequent loss of fragile histidine triad (FHIT) expression in human gastrointestinal tract carcinomas has been reported; however, there were divergent opinions regarding FHIT expression in colorectal carcinoma...
  30. ncbi Genetic deletions in sputum as diagnostic markers for early detection of stage I non-small cell lung cancer
    RuiYun Li
    Department of Surgery, The University of Maryland School of Medicine, 10 South Pine Street, Baltimore, MD 21201, USA
    Clin Cancer Res 13:482-7. 2007
    ..The aim of this study was to determine whether the genetic changes can be used as markers in sputum specimen for the early detection of lung cancer...
  31. ncbi Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers
    H C Pace
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Curr Biol 10:907-17. 2000
    The nucleotide-binding protein Fhit, among the earliest and most frequently inactivated proteins in lung cancer, suppresses tumor formation by inducing apoptosis...
  32. ncbi Abnormalities of fragile histidine triad genomic and complementary DNAs in cervical cancer: association with human papillomavirus type
    C Y Muller
    Department of Obstetrics and Gynecology, Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas 75235 9032, USA
    J Natl Cancer Inst 90:433-9. 1998
    Chromosome 3p14.2 contains FRA3B, the most active chromosome breakage site in the human genome. The fragile histidine triad (FHIT) gene, a putative tumor suppressor gene, overlaps FRA3B...
  33. ncbi Allelic imbalance and abnormal expression of FHIT in endemic nasopharyngeal carcinoma: association with clinicopathological features
    Yan Fei Deng
    Department of Otolaryngology, Zhongshan Hospital, Xiamen University, 209 Hubin South Road, Xiamen, Fujian, 361004, People s Republic of China
    Eur Arch Otorhinolaryngol 267:1933-41. 2010
    The FHIT gene is involved in the pathogenesis of many cancers...
  34. ncbi Direct interaction of the beta-domain of VHL tumor suppressor protein with the regulatory domain of atypical PKC isotypes
    H Okuda
    Department of Urology, Kochi Medical School, Kochi, 783 8505, Japan
    Biochem Biophys Res Commun 263:491-7. 1999
    VHL tumor suppressor protein contains two domains, alpha and beta. The alpha-domain is involved in the formation of a large protein complex suggested to be involved in ubiquitin-mediated protein degradation...
  35. ncbi Structural and biosensor analyses of a synthetic biotinylated peptide probe for the isolation of adenomatous polyposis coli tumor suppressor protein complexes
    J D Wade
    Howard Florey Institute, University of Melbourne, Victoria, Australia
    J Pept Res 58:204-12. 2001
    ..tumors stem from mutations in the gene coding for the production of the adenomatous polyposis coli (APC) tumor suppressor protein. This protein contains a coiled-coil N-terminal domain that is known to be responsible for ..
  36. ncbi Hsp90 chaperones wild-type p53 tumor suppressor protein
    Dawid Walerych
    International Institute of Molecular and Cell Biology in Warsaw, 02 109 Warsaw, Poland
    J Biol Chem 279:48836-45. 2004
    ..used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specific wild-type p53 ..
  37. ncbi The FHIT gene in oral squamous cell carcinoma: allelic imbalance is frequent but cDNA aberrations are uncommon
    S Pateromichelakis
    Department of Oral and Maxillofacial Surgery Molecular Oncology, Guy s, King s and St Thomas School of Dentistry, Caldecot Road, London, UK
    Oral Oncol 36:180-8. 2000
    The FHIT (fragile histidine triad) gene at chromosome 3p14.2 spans the FRA3B fragile site and encodes for a diadenosine triphosphate hydrolase-type protein...
  38. ncbi A novel approach to simultaneously scan genes at fragile sites
    Pascale Willem
    Department of Hematology and Molecular Medicine University of the Witwatersrand and the National Health Laboratory Services, Wits Medical School, 8 York road, 2193 Parktown, South Africa
    BMC Cancer 6:205. 2006
    ..The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing oxidoreductase (WWOX) genes respectively...
  39. ncbi Aberrations of the FHIT gene and Fhit protein in canine lymphoma cell lines
    Hiroko Hiraoka
    Laboratory of Veterinary Internal Medicine, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    J Vet Med Sci 71:769-77. 2009
    The fragile histidine triad (FHIT) gene is a tumor-associated gene, and aberrant FHIT gene and protein expression have been described in many types of human tumors...
  40. ncbi Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors
    J Louhelainen
    ICRF Cancer Medicine Research Unit, Cancer Research Building, St James s University Hospital, Leeds LS9 7TF, UK
    Int J Oncol 18:203-10. 2001
    ..The majority (4/5) of the patients had LOH at or close to the fragile histidine triad (FHIT) gene (3p14.2; D3S1300), which is a candidate tumor suppressor gene for many cancer types...
  41. ncbi Lung cancer susceptibility in Fhit-deficient mice is increased by Vhl haploinsufficiency
    Nicola Zanesi
    Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 65:6576-82. 2005
    The FHIT gene plays important roles in cancer development, including lung cancers, in which the Fhit protein is frequently lost...
  42. ncbi Influence of FHIT on benzo[a]pyrene-induced tumors and alopecia in mice: chemoprevention by budesonide and N-acetylcysteine
    Roumen Balansky
    Department of Health Sciences, University of Genoa, Via A Pastore 1, I 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 103:7823-8. 2006
    The FHIT gene has many hallmarks of a tumor-suppressor gene and is involved in a large variety of cancers...
  43. ncbi Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3
    Pawel Bieganowski
    Structural Biology and Bioinformatics Program, Kimmel Cancer Center, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:10852-60. 2002
    ..hydrolases and nucleotide transferases consists of a branch of proteins related to Hint and Aprataxin, a branch of Fhit-related hydrolases, and a branch of galactose-1-phosphate uridylyltransferase (GalT)-related transferases...
  44. ncbi FHIT mRNA expression in thymoma
    H Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Eur J Surg Oncol 29:904-7. 2003
    The FHIT gene is located at 3p14.2 a region frequently lost in multiple tumour types. Loss of FHIT expression has been found to occur frequently in multiple tumour types...
  45. ncbi Impaired replication dynamics at the FRA3B common fragile site
    Aparna Palakodeti
    Department of Medicine, Section of Hematology Oncology, The University of Chicago, Chicago, IL 60637, USA
    Hum Mol Genet 19:99-110. 2010
    ..replication stress, we examined replication dynamics within a 50 kb region of the most frequently expressed CFS, FRA3B. We mapped four origins of replication, ori 1-4, using two independent methods...
  46. ncbi Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic haemopoietic cells
    M Carapeti
    Department of Haematology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Br J Cancer 78:601-5. 1998
    Deletions and apparent transcriptional abnormalities of the FHIT gene at 3p14.2 have recently been reported in a wide variety of solid tumours...
  47. ncbi The murine Fhit gene is highly similar to its human orthologue and maps to a common fragile site region
    T W Glover
    Department of Pediatrics and Human Genetics, University of Michigan, Ann Arbor 48109, USA
    Cancer Res 58:3409-14. 1998
    ..exhibits both genomic deletions and aberrant transcripts in a variety of tumors and spans the common fragile site FRA3B. This fragile site extends over a broad region of several hundred kb within the FHIT gene and may account for its ..
  48. ncbi DNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area
    X Q Guo
    Department of Endoscopy, The 4th Affiliated Hospital, Hebei Medical University, China
    J Exp Clin Cancer Res 26:587-94. 2007
    ..The purpose of this study was to investigate aberrant promoter methylation of the p16 and FHIT genes in tissues and plasma and loss of protein expression in esophageal precancerous conditions (EPC) and ..
  49. ncbi A hybrid machine learning-based method for classifying the Cushing's Syndrome with comorbid adrenocortical lesions
    Jack Y Yang
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Genomics 9:S23. 2008
    ..as hTERT, PCNA and Ki-67 can be considered as cancer markers, while another set of antigens such as P27KIP1 and FHIT are possible markers for normal tissue...
  50. ncbi FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations
    A Marchetti
    Department of Oncology, University of Pisa, Italy
    J Pathol 184:240-6. 1998
    ..of 51 BACs, previously investigated for K-ras gene mutations, has evaluated the status of two other genes, p53 and FHIT, known to be frequently altered in non-small cell lung cancer...
  51. ncbi Chromosomal fragile sites FRA3B and FRA16D show correlated expression and association with failure of apoptosis in lymphocytes from patients with thyroid cancer
    Isabella Sbrana
    Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy
    Genes Chromosomes Cancer 45:429-36. 2006
    ..This appears to be the case for FRA3B and FRA16D, localized in two tumor-suppressor genes (FHIT and WWOX, respectively) that are altered by deletions or ..
  52. ncbi p53 and FHIT mutations and microsatellite alterations in malignancy-associated pleural effusion
    Jin Hwa Lee
    Department of Internal Medicine, Medical Research Center, Ewha Womans University Mokdong Hospital, 911 1 Mokdong Yangcheon gu, Seoul 158 710, South Korea
    Lung Cancer 44:33-42. 2004
    ..whether the genetic analysis of pleural fluid can be used to diagnose malignant effusion, we investigated p53 and FHIT mutations and microsatellite alterations (MA) in the pleural fluid of 40 patients with pleural effusion associated ..
  53. ncbi Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
    Martin F Arlt
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109 0618, USA
    Genes Chromosomes Cancer 33:82-92. 2002
    The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated FHIT gene...
  54. ncbi Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit
    T Shiraishi
    Kimmel Cancer Center, Jefferson Medical College, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:5722-7. 2001
    ..This study describes a comparison of orthologous fragile regions, the human FRA3B/FHIT and the murine Fra14A2/Fhit locus...
  55. ncbi The common fragile site FRA16D and its associated gene WWOX are highly conserved in the mouse at Fra8E1
    Kurt A Krummel
    Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
    Genes Chromosomes Cancer 34:154-67. 2002
    ..CFSs) have been cloned and characterized, including the two most frequently observed in the human population, FRA3B and FRA16D...
  56. ncbi Fragile histidine triad protein: structure, function, and its association with tumorogenesis
    Md Imtaiyaz Hassan
    Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India
    J Cancer Res Clin Oncol 136:333-50. 2010
    The human fragile histidine triad (FHIT) gene is a putative tumor suppressor gene, which is located at chromosome region 3p14.2...
  57. ncbi [Expression of fragile histidine triad (FHIT) protein and its significance in diagnosing classical Hodgkin lymphoma]
    Po Zhao
    Department of Pathology, General Hospital of Chinese People s Liberation Army, Beijing 100853, China
    Zhonghua Bing Li Xue Za Zhi 35:289-91. 2006
    To study the expression of FHIT protein and its potential application in diagnosing classic Hodgkin lymphoma.
  58. ncbi The von Hippel-Lindau tumor suppressor protein
    M Ivan
    Howard Hughes Medical Institute, Dana-Farber Cancer Institute and Brigham and Womens Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 11:27-34. 2001
    The von Hippel-Lindau tumor suppressor protein (pVHL) has been shown to bind directly to the alpha subunits of the heterodimeric transcription factor HIF (hypoxia inducible factor)...
  59. ncbi A Fhit-ing role in the DNA damage checkpoint response
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
    Cell Cycle 6:1044-8. 2007
    ..Finally, results of a recent study have suggested that the DNA damage-susceptible FRA3B/FHIT chromosome fragile region, paradoxically, encodes a protein, Fhit, that is necessary for protecting cells ..
  60. ncbi Lack of association of fragile histidine triad (FHIT) polymorphisms with lung cancer in the Korean population
    Hae Yun Jung
    Department of Internal Medicine and Brain Korea 21 Project for Biomedical Science, Genomic Research Center for Lung and Breast Ovarian Cancers, Korea University College of Medicine, 126 1, Anam Dong 5Ga, Sungbuk Gu, Seoul 136 705, Korea
    J Hum Genet 52:668-74. 2007
    The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer...
  61. ncbi Aberrant methylation of tumor suppressor genes in patients with refractory anemia with ring sideroblasts
    Ana Valencia
    Department of Hematology, Hospital Universitario La Fe, Avda Campanar 21, 46009 Valencia, Spain valencia
    Leuk Res 35:479-83. 2011
    ..The genes methylated were CDKN2B (20%), RASSF1 (18%), RARB (10%), CDH13 (7.5%) and FHIT (5%)...
  62. ncbi Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
    ..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects...
  63. ncbi Loss expression of active fragile sites genes associated with the severity of breast epithelial abnormalities
    Tian Tian Wang
    Department of General Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China
    Chin Med J (Engl) 121:1969-74. 2008
    WWOX and FHIT are two candidate tumor suppressor genes located in active fragile sites, the damage of which has been associated with the development of breast cancer...
  64. ncbi Promoter methylation profile in gallbladder cancer
    Juan Carlos Roa
    Department of Pathology, Faculty of Medicine, Universidad de La Frontera, Manuel Montt 112, Temuco, 478 1176, Chile
    J Gastroenterol 41:269-75. 2006
    ..Our objective was to analyze the methylation pattern of some of the genes involved in carcinogenesis of the gallbladder, examining the immunohistochemical expression of proteins, clinical features, and patient survival time...
  65. ncbi Fragile histidine triad gene inactivation in lung cancer: the European Early Lung Cancer project
    Carla Verri
    Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
    Am J Respir Crit Care Med 179:396-401. 2009
    Fragile histidine triad (FHIT) is a tumor suppressor gene involved in the pathogenesis of lung cancer.
  66. ncbi Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit
    Bartosz Ferens
    Department of Biotechnology, Division of Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Kladki 24, 80 822 Gdansk, Poland
    Cancer Lett 280:101-9. 2009
    The tumor suppressor Fhit protein lost in many human pre-malignant tissues, possesses diadenosine triphosphate activity regulated by a photosensitizer, protoporphyrin IX (PpIX) in vitro...
  67. ncbi [Expressions of FHIT and PTEN and their significance in prostate cancer]
    Qin Xiao
    Department of Pathology, Northern Jiangsu People s Hospital, Yangzhou, Jiangsu 225001, China
    Zhonghua Nan Ke Xue 17:136-9. 2011
    To investigate the expressions of the FHIT and PTEN genes and their significance in prostate cancer.
  68. ncbi microRNA-143 protects cells from DNA damage-induced killing by downregulating FHIT expression
    Yu Xiang Lin
    Department of Medical Molecular Biology, Beijing Institute of Biotechnology, China
    Cancer Biother Radiopharm 26:365-72. 2011
    ..Recent studies suggest roles of miRNAs in carcinogenesis. Fragile histidine triad (FHIT) gene deletion, methylation, and reduced Fhit protein expression occur in about 70% of human epithelial tumors and ..
  69. ncbi Clinicopathological significance of FHIT protein expression in gastric adenocarcinoma patients
    Po Zhao
    Department of Pathology, Chinese People s Liberation Army General Hospital, Beijing 100853, China
    World J Gastroenterol 11:5735-8. 2005
    To investigate the expression of fragile histidine triad (FHIT) protein, and the possible relationship between FHIT expression and clinicopathological indices in gastric carcinoma.
  70. ncbi FHIT gene expression is repressed by mitogenic signaling through the PI3K/AKT/FOXO pathway
    Kevin Kelley
    Wright State University, Boonshoft School of Medicine, Biochemistry and Molecular Biology Department, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USA
    Am J Cancer Res 1:62-70. 2011
    The Fragile Histidine Triad gene or FHIT functions as tumor suppressor in many epithelial cell types...
  71. ncbi The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer
    Christine H Holschneider
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1740, USA
    Clin Cancer Res 11:5756-63. 2005
    ..hypothesized that reduced FHIT protein expression, homozygous deletions (HD) or hemizygous deletions (HemiD) and microsatellite alterations (MA) at the FHIT/FRA3B locus occur more commonly in cervical cancers of smokers than nonsmokers.
  72. ncbi Prevention of urinary bladder cancer in the FHIT knock-out mouse with Rofecoxib, a Cox-2 inhibitor
    Domenico D'Arca
    Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Urol Oncol 28:189-94. 2010
    ..COX-2 inhibitor, rofecoxib, in the development of urinary bladder cancer, we studied the effect of this drug in heterozygous and nullizygous fragile histidine triad (FHIT) gene-deficient mice in a chemically induced carcinogenesis model.
  73. ncbi Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions
    Flavia Pichiorri
    Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University and Comprehensive Cancer Center, Columbus, Ohio 43210, USA
    J Biol Chem 284:1040-9. 2009
    We have previously shown that Fhit tumor suppressor protein interacts with Hsp60 chaperone machinery and ferredoxin reductase (Fdxr) protein...
  74. ncbi [Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues]
    Xiaomin Yin
    Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 35:572-5. 2010
    To determine the role of fragile histidine triad (FHIT) and MDM2 in carcinogenesis of oral submucous fibrosis (OSF).
  75. ncbi [Mutation and abnormal expression of FHIT gene in hypopharyngeal carcinoma]
    Hao Wu
    Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:245-8, 253. 2009
    To analyze the mutation and abnormal expression of the FHIT gene in human hypopharyngeal carcinoma.
  76. ncbi Expression of Fhit, Mlh1, p16INK4A and E-cadherin in early gastric neoplasia: Correlation with histological grade and gastric phenotype
    Akihito Hara
    Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Oncol Rep 18:553-9. 2007
    ..The protein expression of 4 TSGs including Fhit, Mlh1, p16INK4A and E-cadherin was examined using immunohistochemical methods in 103 early gastric neoplasias, ..
  77. ncbi Microsatellite analysis of induced sputum DNA in patients with lung cancer in heavy smokers and in healthy subjects
    A Castagnaro
    Department of Clinical Science, Section of Respiratory Medicine, University of Parma, Parma, Italy
    Exp Lung Res 33:289-301. 2007
    Abnormality in the fragile histidine triade (FHIT), a candidate tumor suppressor gene located in chromosome region 3 (3p14.2), has been frequently found in multiple tumor types, including lung cancer...
  78. ncbi Genetic polymorphisms of methylenetetrahydrofolate reductase and promoter methylation of MGMT and FHIT genes in diffuse large B cell lymphoma risk in Middle East
    Abdul K Siraj
    Department of Human Cancer Genomic Research Centre, King Fahad National Center for Children s Cancer and Research, Riyadh, Saudi Arabia
    Ann Hematol 86:887-95. 2007
    ..The O6 methylguanine DNA methyltransferase (MGMT) and fragile histidine triad (FHIT) genes are transcriptionally silenced by promoter hypermethylation in DLBCL...
  79. ncbi Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer
    Matthias Woenckhaus
    Department of Pathology, University of Regensburg, D 93053 Regensburg, Germany
    Hum Pathol 39:126-36. 2008
    ..dickkopf, Xenopus, homolog of 3 (DKK3 gene), fibroblast growth factor receptor 3 (FGFR3), fragile histidine triad (FHIT), tumor protein p53 (TP53), mucin1 (MUC1), topoisomerase II alpha (TOP2A), and glutathione S-transferase-Pi (GST) ..
  80. ncbi [Alteration of methylation status of fragile histidine triad gene promoter in patients with myelodysplastic syndrome]
    Dong ming Yao
    The Affiliated People s Hospital, Jiangsu University, Zhengjiang, Jiangsu, People s Republic of China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:36-9. 2008
    To study the methylation status of fragile histidine triad (FHIT) gene promoter in patients with myelodysplastic syndrome (MDS) and its clinical relevance.
  81. ncbi Fhit modulates the DNA damage checkpoint response
    Hideshi Ishii
    Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan
    Cancer Res 66:11287-92. 2006
    In preneoplastic lesions, the DNA damage checkpoint is induced and loss of heterozygosity at the FRA3B/FHIT common chromosome fragile region precedes or is coincident with activation of the checkpoint response in these early stages...
  82. ncbi [Effect of 5-Aza-dC on FHIT gene expression in hepatocellular carcinoma cell line HepG2]
    Hong Li Li
    Medicine Research Experiment Center of Science Research, Weifang Medical College, Weifang, Shandong, 261042, PR China
    Ai Zheng 28:967-71. 2009
    b>FHIT gene methylation leads to down-regulation of its expression in hepatocellular carcinoma (HCC) cells...
  83. ncbi Alterations of FHIT gene and P16 gene in nickel transformed human bronchial epithelial cells
    Wei dong Ji
    Institute for Chemical Carcinogenesis, Guangzhou Medical College, Guangzhou 510182, Guangdong, China
    Biomed Environ Sci 19:277-84. 2006
    To study the alterations of FHIT gene and P16 gene in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide using an immortal human bronchial epithelial cell line, and to explore the molecular ..
  84. ncbi Fragile histidine triad (FHIT) gene is overexpressed in colorectal cancer
    P M Wierzbicki
    Department of Histology, Medical University of Gdansk, Gdansk, Poland
    J Physiol Pharmacol 60:63-70. 2009
    FHIT gene, mapped at FRA3B site, encodes human diadenosine triphosphate hydrolase involved in the regulation of cell cycle and nucleotide metabolism...
  85. ncbi Aberrant FHIT protein expression in classical Hodgkin's lymphoma: a potential marker
    Po Zhao
    Department of Pathology, General Hospital of Chinese People s Liberation Army, Beijing, People s Republic of China
    Pathology 38:399-402. 2006
    The fragile histidine triad (FHIT) gene is frequently inactivated in human cancers; however, the FHIT gene remains unexplored in Hodgkin's lymphoma...
  86. ncbi Analysis of FHIT allelic imbalance/loss of heterozygosity and FHIT expression in cutaneous squamous cell carcinomas
    Sarah E Gray
    Pathology Department, Molecular Oncology Laboratory, Royal College of Surgeons in Ireland, Dublin, Ireland
    J Cutan Pathol 35:816-25. 2008
    Aberrations of the tumor suppressor gene, the fragile histidine triad gene (FHIT), have been reported in a wide variety of human cancers including cervical carcinoma, oral squamous cell carcinoma (SCC) and oesophageal SCC...
  87. ncbi Decreased fragile histidine triad gene messenger RNA expression in lung cancer
    Hidefumi Sasaki
    Department of Surgery II, Nagoya City University Medical School, Nagoya, Japan
    Clin Lung Cancer 7:412-6. 2006
    The fragile histidine triad (FHIT) gene is located at 3p14.2, a region frequently lost in various tumor types. Lack of FHIT expression has been found to occur frequently in multiple tumor types including lung cancer...
  88. ncbi Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma
    Po Zhao
    Department of Pathology, Chinese People s Liberation Army PLA General Hospital, Beijing, China
    Acta Oncol 47:1557-63. 2008
    This is the first study to explore the relationship between the expression of fragile histidine triad, FHIT and cyclin D1 proteins, and the clinicopathological significance of the two proteins in Chinese patients with cholangiocarcinoma.
  89. ncbi Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site
    Anne Letessier
    Institut Curie, Centre de Recherche, 26 Rue d Ulm, 75248 Paris, France
    Nature 470:120-3. 2011
    ..Here we show, in contrast to this view, that the fragility of FRA3B--the most active common fragile site in human lymphocytes--does not rely on fork slowing or stalling but on a ..
  90. ncbi A possible involvement of aberrant expression of the FHIT gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix
    S Nakagawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Japan
    Br J Cancer 79:589-94. 1999
    To investigate involvement of an aberrant expression of the FHIT (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase ..
  91. ncbi Aberrations in the fragile histidine triad (FHIT) gene in idiopathic pulmonary fibrosis
    K Uematsu
    The Fourth Department of Medicine, Nippon Medical School, Tokyo 113 8603, Japan
    Cancer Res 61:8527-33. 2001
    ..from microdissected tissues; fluorescent in situ hybridization (FISH) analysis of the fragile histidine triad (FHIT) gene and immunohistochemical analysis of Fhit protein expression in samples of metaplasias and bronchiolar ..
  92. ncbi Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma
    Q Yang
    Department of General Surgery, Affiliated Kihoku Hospital, Wakayama Medical University, 649 7113 Katuragi cho, Japan
    Clin Cancer Res 7:3869-73. 2001
    The fragile histidine triad (Fhit) gene, which is frequently lost in many cancers, was identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2...
  93. ncbi Decreased FHIT protein expression correlates with a worse prognosis in patients with diffuse large B-cell lymphoma
    Po Min Chen
    Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No 201 Shih Pai Road, Section 2, Taipei 112, Taiwan, R O C
    Oncol Rep 11:349-56. 2004
    This study was conducted to evaluate the expression of the presumptive tumor suppressor gene, FHIT (fragile histidine triad) and its clinical significance in non-Hodgkin's lymphoma (NHL)...
  94. ncbi Fhit protein expression in endometrial cancers: no correlation with histological grade
    P Hadaczek
    Department of Genetics and Pathology, Pomeranian Academy of Medicine, Szczecin
    Pol J Pathol 52:199-203. 2001
    The genes specifically involved in endometrial cancers have not yet been discovered. The FHIT gene, a tumour suppressor located at 3p14.2, is altered in many human tumours, including those derived from the female genital tract...
  95. ncbi [Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549]
    Yun Wang
    Department of Thoraco Cardiac Surgery, West China Hospital, Basic Medical College, Cancer Institute, West China Hospital Sichuan University, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:225-9. 2002
    To explore the role of fragile histidine triad(FHIT) gene in the proliferation, apoptosis and tumorigenesis of human lung cancer cells.
  96. ncbi Loss of Fhit expression as a potential marker of malignant progression in preinvasive squamous cervical cancer
    David Butler
    Department of Pathology, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland
    Gynecol Oncol 86:144-9. 2002
    ..the same cases of squamous cervical neoplasia and microinvasive carcinoma (MICA) we found an association between FHIT gene deletion and infection with high-risk HPV (HR HPV)...
  97. ncbi Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma
    Tamotsu Kuroki
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 63:3724-8. 2003
    ..retinoic acid receptor beta (RAR-beta), RAS association domain family 1A (RASSF1A), and fragile histidine triad (FHIT) genes in 22 esophageal squamous cell carcinoma cell lines and 47 primary tumors and corresponding noncancerous ..
  98. ncbi Deletion of the FHIT gene in human colorectal cancer is independent of high-risk HPV infection
    Hong Gang Yu
    Department of Gastroentrerology, Renmin Hospital of Wuhan University, 430060 Wuhan, China
    Int J Colorectal Dis 17:396-401. 2002
    The fragile histidine triad (FHIT) gene, which is frequently lost in many cancers, has been identified as a candidate tumor suppressor gene at chromosome 3p locus 14.2...
  99. ncbi No relationship is indicated between FHIT expression and clinicopathologic prognostic parameters in early stage cervical carcinoma
    C Baykal
    SSK Ankara Maternity Hospital Gynecologic Oncology Clinic, Turkey
    Int J Gynecol Cancer 13:192-6. 2003
    In this study we investigated FHIT (Fragile Histidine Triad) protein alterations in cervical carcinomas to assess the relation of this gene with cervical cancer...
  100. ncbi Abnormal FHIT gene transcript and c-myc and c-erbB2 amplification in breast cancer
    Renata Kowara
    Department of Molecular Medicine, Medical University of Gdansk, Poland
    Acta Biochim Pol 49:341-50. 2002
    ..for ways to improve the characterization of breast cancer we examined the relationship between the status of the FHIT gene transcript and amplification of c-myc and the c-erbB2 oncogene...
  101. ncbi Loss of fragile histidine triad expression in colorectal carcinoma
    Po Zhao
    Department of Pathology, Chinese General Hospital of the People s Liberation Army, Beijing 100853, China
    Zhonghua Bing Li Xue Za Zhi 31:124-7. 2002
    To investigate the expression of fragile histidine triad (FHIT) gene protein, FHIT and the possible relationship between FHIT expression and clinicopathological indices in colorectal carcinoma.

Research Grants67

  1. EFFECTS OF BENZO[A]PYRENE IN TRANSGENIC MODEL OF CERVICA
    ELLEN RORKE; Fiscal Year: 2002
    ..E6 and E7, that are required for cell immortalization, E6 causes degradation of the cell cycle checkpoint/tumor suppressor protein, p53...
  2. Human Neurotropic JC Virus and CNS Diseases
    Kamel Khalili; Fiscal Year: 2006
    ..lytic cycle and possesses the ability to interact with several important cellular proteins including the tumor suppressor protein, p53, pointing to the oncogenic potential of this virus...
  3. Inducible Dysplastic Nephropathy in B2-Deficient Mice
    Samir S El Dahr; Fiscal Year: 2010
    ..A physiological cross-talk operates between the tumor suppressor protein, p53, and the BdkrB2 during renal organogenesis...
  4. DEPENDENCE OF P53 ON THIOL MAINTENANCE PROTEINS
    Gary Merrill; Fiscal Year: 2001
    Stimulation of transcription by the human tumor suppressor protein p53 is compromised in yeast lacking the enzyme thioredoxin reductase (Trr1). The result suggests that p53 is prone to oxidative inactivation...
  5. Mechanism of Renal Cell Injury in Diabetes
    Goutam Ghosh Choudhury; Fiscal Year: 2010
    ..We have shown recently that high glucose- as well as TGF-induced downregulation of tumor suppressor protein PTEN (phosphatase and tensin homolog deleted on chromosome ten) contributes to renal cell hypetrophy and ..
  6. Alteration of Rb in HTLV-1 transformed cells
    Fatah Kashanchi; Fiscal Year: 2005
    ..A significant regulator of the G1 restriction point in eukaryotic cells is the tumor suppressor protein retinoblastoma (Rb)...
  7. EXPRESSION OF MATRIX METALLOPROTEINASE AND P53
    Yubo Sun; Fiscal Year: 2004
    ..My specific research interest is to study the role of tumor suppressor protein and proto-oncogene proteins in the regulation of gene expression of MMPs and TIMPs and in the regulation ..
  8. 12th International p53 Workshop
    Carol Prives; Fiscal Year: 2006
    The p53 tumor suppressor protein plays pivotal roles in tumor suppression and its gene is the most frequently mutated in human cancers...
  9. Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor Suppression
    Peiqing Sun; Fiscal Year: 2010
    ..ras-induced senescence and tumor suppression both in vitro and in vivo, and that PRAK is likely to be a tumor suppressor protein. Our preliminary data reveal that PRAK directly interacts with a multifunctional histone ..
  10. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    LAURIE GOODYEAR; Fiscal Year: 2009
    ..The tumor suppressor protein LKB1 has recently been identified as an upstream kinase for AMPK and 12 other AMPK-related proteins...
  11. Study of a FACTp140-SSRP1-associated p53 Kinase
    Hua Lu; Fiscal Year: 2006
    ..this proposal is to understand the molecular and biochemical basis underlying the regulation of the p53 tumor suppressor protein in mammalian systems...
  12. Exercise Regulation of Glucose Metabolism in Skeletal Muscle
    Laurie J Goodyear; Fiscal Year: 2010
    ..The tumor suppressor protein LKB1 has recently been identified as an upstream kinase for AMPK and 12 other AMPK-related proteins...
  13. Biology of the Myb-MuvB Oncoprotein-Tumor Suppressor Protein Complex
    JOSEPH STEVEN LIPSICK; Fiscal Year: 2010
    ....
  14. Molecular Basis of Aneuploidy
    Debananda Pati; Fiscal Year: 2009
    ..While tumor suppressor protein p53 and steroid hormones such as androgens have long been implicated in the development of osteosarcoma ..
  15. MECHANISMS OF ENZYMATIC REACTIONS
    PERRY FREY; Fiscal Year: 2002
    ..uridlyltransferase (Ga1T), galactokinase (Ga1K), dTDP-glucose 4,6-dehydratase (dehydratase) and human Fhit, a putative tumor suppressor...
  16. Structure-Function of Protein Deacetylases
    Ronen Marmorstein; Fiscal Year: 2007
    ..to HDACs have more recently been shown to deacetylate non-histone protein targets in vivo such as the p53 tumor suppressor protein for DNA repair regulation and alpha-tubulin for maintenance of cell integrity, suggesting that these ..
  17. FUNCTIONAL AND STRUCTURAL ANALYSIS OF HIT PROTEINS
    Charles Brenner; Fiscal Year: 2006
    ..The Fhit branch of the HIT superfamily contains enzymes that hydrolyze diadenosine polyphosphates (ApnA)...
  18. p38 MAPK in Ras-induced Senescence and Transformation
    Peiqing Sun; Fiscal Year: 2010
    ..senescence operates in vivo to suppress cancer development in murine models, and that PRAK is a tumor suppressor protein that is inactivated in certain types of human cancer...
  19. Characterization of WWOX, the Cancer Gene Spanning FRA16D
    CLAUDIO MARCELO ALDAZ; Fiscal Year: 2010
    ..We identified that the WWOX tumor suppressor protein physically interacts with and represses RUNX2 transcriptional activity...
  20. PROPERTIES AND REGULATION OF P53 IN TUMOR CELLS
    Carol Prives; Fiscal Year: 2010
    The p53 tumor suppressor protein is likely the most well studied mammalian transcription factor...
  21. ANTIAPOPTOTIC MECHANISMS IN PROSTATE CANCER
    ALBERT BALDWIN; Fiscal Year: 2002
    ..CWR22R tumors displayed elevated Bcl-2 and c-Myc proteins as well as cytoplasmic localization of the tumor suppressor protein p53...
  22. FOXO1 Inhibition in Genotoxic Stress Response and Prostate Cancer Survival
    Haojie Huang; Fiscal Year: 2010
    ..of the forkhead transcription factor FOXO1 induces apoptosis in PCa cells, suggesting that FOXO1 is a tumor suppressor protein. This notion is further supported by recent findings from our laboratory, as well as our colleagues',..
  23. Chemical Modulators for p53 Functions in Transcriptional Regulation
    SYED S MUJTABA; Fiscal Year: 2010
    The most essential human tumor suppressor protein p53 is mutated in more than 50% of the human cancers...