Gene Symbol: FGF7
Description: fibroblast growth factor 7
Alias: HBGF-7, KGF, fibroblast growth factor 7, FGF-7, heparin-binding growth factor 7, keratinocyte growth factor
Species: human
Products:     FGF7

Top Publications

  1. Danan C, Franco M, Jarreau P, Dassieu G, Chailley Heu B, Bourbon J, et al. High concentrations of keratinocyte growth factor in airways of premature infants predicted absence of bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2002;165:1384-7 pubmed
    Premature lungs are highly susceptible to lung injuries, leading to bronchopulmonary dysplasia (BPD). Keratinocyte growth factor (KGF) is produced by the developing lung and may reduce the risk of BPD by preventing injury to the lung ..
  2. Brehm J, Hagiwara K, Tesfaigzi Y, Bruse S, Mariani T, Bhattacharya S, et al. Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease. Thorax. 2011;66:1085-90 pubmed publisher
    ..the authors identified two single nucleotide polymorphisms (SNPs) in a novel gene (fibroblast growth factor-7 (FGF7)) that gained genome-wide significance by the false discovery rate method...
  3. Raffa S, Leone L, Scrofani C, Monini S, Torrisi M, Barbara M. Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF/FGF7 secretion. Histochem Cell Biol. 2012;138:251-69 pubmed publisher
    The keratinocyte growth factor (KGF/FGF7), produced by stromal cells, is a key paracrine mediator of epithelial proliferation, differentiation and migration...
  4. Berent Maoz B, Montecino Rodriguez E, Signer R, Dorshkind K. Fibroblast growth factor-7 partially reverses murine thymocyte progenitor aging by repression of Ink4a. Blood. 2012;119:5715-21 pubmed publisher
    ..of Ink4a in aged ETPs results in their partial rejuvenation and that this can be accomplished by in vivo fibroblast growth factor 7 administration...
  5. Rubin J, Osada H, Finch P, Taylor W, Rudikoff S, Aaronson S. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A. 1989;86:802-6 pubmed
    ..The factor, provisionally termed keratinocyte growth factor (KGF) because of its predominant activity on this cell type, was purified to homogeneity by a ..
  6. Werner S, Smola H, Liao X, Longaker M, Krieg T, Hofschneider P, et al. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science. 1994;266:819-22 pubmed
    The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes...
  7. Kovacs D, Falchi M, Cardinali G, Raffa S, Carducci M, Cota C, et al. Immunohistochemical analysis of keratinocyte growth factor and fibroblast growth factor 10 expression in psoriasis. Exp Dermatol. 2005;14:130-7 pubmed
    ..Few studies, however, have focused on the possible involvement of the keratinocyte growth factor (KGF/FGF-7) and the fibroblast growth factor 10 (FGF-10/KGF-2), which are secreted by fibroblasts and ..
  8. Bonay M, Boutten A, Leçon Malas V, Marchal J, Soler P, Fournier M, et al. Hepatocyte and keratinocyte growth factors and their receptors in human lung emphysema. BMC Pulm Med. 2005;5:13 pubmed
    ..expression of hepatocyte and keratinocyte growth factors or their respective receptors, c-met and keratinocyte growth factor receptor...
  9. Riley B, Mansilla M, Ma J, Daack Hirsch S, Maher B, Raffensperger L, et al. Impaired FGF signaling contributes to cleft lip and palate. Proc Natl Acad Sci U S A. 2007;104:4512-7 pubmed
    ..sequenced the coding regions and performed association testing on 12 genes (FGFR1, FGFR2, FGFR3, FGF2, FGF3, FGF4, FGF7, FGF8, FGF9, FGF10, FGF18, and NUDT6) and used protein structure analyses to predict the function of amino acid ..

More Information

Publications111 found, 100 shown here

  1. Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, Torrisi M, et al. Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes. Exp Cell Res. 2007;313:1758-77 pubmed
    b>Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR)...
  2. Belleudi F, Leone L, Nobili V, Raffa S, Francescangeli F, Maggio M, et al. Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways. Traffic. 2007;8:1854-72 pubmed
    The keratinocyte growth factor receptor (KGFR)/fibroblast growth factor receptor 2b is activated by high-affinity-specific interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/..
  3. Visco V, Bava F, d Alessandro F, Cavallini M, Ziparo V, Torrisi M. Human colon fibroblasts induce differentiation and proliferation of intestinal epithelial cells through the direct paracrine action of keratinocyte growth factor. J Cell Physiol. 2009;220:204-13 pubmed publisher
    The effects exerted by the keratinocyte growth factor (KGF) on intestinal epithelial cells cultured in vitro are influenced by cell confluence and differentiation through the modulation of keratinocyte growth factor receptor (KGFR) ..
  4. Teumer A, Rawal R, Homuth G, Ernst F, Heier M, Evert M, et al. Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk. Am J Hum Genet. 2011;88:664-73 pubmed publisher
    ..The third locus marks FGF7, which encodes fibroblast growth factor 7. Members of this protein family have been discussed as putative signal molecules involved in the ..
  5. Cai Y, Wang W, Liang H, Sun L, Teitelbaum D, Yang H. Keratinocyte growth factor up-regulates Interleukin-7 expression following intestinal ischemia/reperfusion in vitro and in vivo. Int J Clin Exp Pathol. 2012;5:569-80 pubmed
    ..of neighboring intestinal intraepithelial lymphocytes (IEL) development and homeostasis, and IEL derived keratinocyte growth factor (KGF) promotes intestinal epithelial growth, which was regulated by EC-derived IL-7...
  6. Miki T, Bottaro D, Fleming T, Smith C, Burgess W, Chan A, et al. Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A. 1992;89:246-50 pubmed
    Expression cDNA cloning and structural analysis of the human keratinocyte growth factor receptor (KGFR) revealed identity with one of the fibroblast growth factor (FGF) receptors encoded by the bek gene (FGFR-2), except for a divergent ..
  7. Finch P, Rubin J, Miki T, Ron D, Aaronson S. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science. 1989;245:752-5 pubmed
    b>Keratinocyte growth factor (KGF) is a human mitogen that is specific for epithelial cells. The complementary DNA sequence of KGF demonstrates that it is a member of the fibroblast growth factor family...
  8. Ornitz D, Xu J, Colvin J, McEwen D, MacArthur C, Coulier F, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996;271:15292-7 pubmed
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways. ..
  9. Igarashi M, Finch P, Aaronson S. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J Biol Chem. 1998;273:13230-5 pubmed
    ..The predicted FGF-10 protein is most related to keratinocyte growth factor (KGF, or FGF-7)...
  10. Ware L, Matthay M. Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. Am J Physiol Lung Cell Mol Physiol. 2002;282:L924-40 pubmed
    A growing body of evidence indicates that the epithelial-specific growth factors keratinocyte growth factor (KGF), fibroblast growth factor (FGF)-10, and hepatocyte growth factor (HGF) play important roles in lung development, lung ..
  11. Kovacs D, Cota C, Cardinali G, Aspite N, Bolasco G, Amantea A, et al. Expression of keratinocyte growth factor and its receptor in clear cell acanthoma. Exp Dermatol. 2006;15:762-8 pubmed
    ..As it has been recently demonstrated that in psoriatic lesions the paracrine epithelial growth factors [keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)-7 and FGF-10] are involved in promoting and sustaining the ..
  12. Toyokawa T, Yashiro M, Hirakawa K. Co-expression of keratinocyte growth factor and K-sam is an independent prognostic factor in gastric carcinoma. Oncol Rep. 2009;21:875-80 pubmed
    b>Keratinocyte growth factor (KGF) from gastric fibroblasts have been reported to stimulate proliferation of scirrhous gastric cancer cells with K-samII amplification in a paracrine manner...
  13. Cheng C, Wang D, Kao M, Chen J. The growth-promoting effect of KGF on limbal epithelial cells is mediated by upregulation of DeltaNp63alpha through the p38 pathway. J Cell Sci. 2009;122:4473-80 pubmed publisher
    ..b>Keratinocyte growth factor (KGF) and hepatocyte growth factor (HGF) are two paracrine factors that regulate the proliferation, ..
  14. Sangild P, Ney D, Sigalet D, Vegge A, Burrin D. Animal models of gastrointestinal and liver diseases. Animal models of infant short bowel syndrome: translational relevance and challenges. Am J Physiol Gastrointest Liver Physiol. 2014;307:G1147-68 pubmed publisher
    ..g., glucagon-like peptide 2, growth hormone, insulin-like growth factor 1, epidermal growth factor, keratinocyte growth factor)...
  15. Xu W, Chen J, Liu X, Li H, Qi X, Guo X. Autologous bone marrow stromal cell transplantation as a treatment for acute radiation enteritis induced by a moderate dose of radiation in dogs. Transl Res. 2016;171:38-51 pubmed publisher
    ..of the anti-inflammatory cytokine interleukin-11 (IL10) and intestinal radioprotective factors, such as keratinocyte growth factor, basic fibroblast growth factor-2, and platelet-derived growth factor-B while reducing the serum level ..
  16. Panneerselvam L, Raghunath A, Perumal E. Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats. Int J Cardiol. 2017;229:96-101 pubmed publisher
    ..In order to study this, male Wistar rats were treated with single oral doses of 45 and 90mg/kgF- for 24h...
  17. Tarnawski A, Ahluwalia A. Molecular mechanisms of epithelial regeneration and neovascularization during healing of gastric and esophageal ulcers. Curr Med Chem. 2012;19:16-27 pubmed
    ..Esophageal ulcer healing follows similar pattern to gastric ulcer, but KGF and its receptor are the key players in regeneration of the epithelium...
  18. Utley S, James D, Mavila N, Nguyen M, Vendryes C, Salisbury S, et al. Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation. J Hepatol. 2014;60:1002-9 pubmed publisher
    ..phospho-Serine 552 (pSer552) β-Catenin in association with up-regulation of genes encoding the FGFR2IIIb ligands, Fgf7, Fgf10, and Fgf22...
  19. Huang H, Chan Y, Wu C, Chen J. Tilapia Piscidin 4 (TP4) Stimulates Cell Proliferation and Wound Closure in MRSA-Infected Wounds in Mice. Mar Drugs. 2015;13:2813-33 pubmed publisher
    ..In vitro, TP4 stimulated cell proliferation and activated collagen I, collagen III, and keratinocyte growth factor (KGF) gene expression in Hs-68 cells, which induces keratin production by HaCaT cells...
  20. Zaleska M, Olszewski W. Serum Immune Proteins in Limb Lymphedema Reflecting Tissue Processes Caused by Lymph Stasis and Chronic Dermato-lymphangio-adenitis (Cellulitis). Lymphat Res Biol. 2017;15:246-251 pubmed publisher
    ..box 1 (HMGB1), and serpin, (2) cell growth regulating factors such as cortisol, human growth hormone, keratinocyte growth factor, and insulin-like growth factor (IGF), and (3) angiogenic and growth factors such as angiopoetins 1 and ..
  21. Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, et al. Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol. 2016;56:24-41 pubmed publisher
    ..proliferation and hair follicle development in adult but not new born Lama5Ker5 skin, including KGF, EGF and KGF-2...
  22. Stone M, Zhao Y, Robert Smith J, Weiss M, Kron I, Laubach V, et al. Mesenchymal stromal cell-derived extracellular vesicles attenuate lung ischemia-reperfusion injury and enhance reconditioning of donor lungs after circulatory death. Respir Res. 2017;18:212 pubmed publisher
    ..A significant decrease in proinflammatory cytokines (IL-17, TNF-α, CXCL1 and HMGB1) and upregulation of keratinocyte growth factor, prostaglandin E2 and IL-10 occurred in the BAL fluid from MSC or EV-treated mice after IR compared to ..
  23. Salem A, Mistry H, Backen A, Hodgson C, Koh P, Dean E, et al. Cell Death, Inflammation, Tumor Burden, and Proliferation Blood Biomarkers Predict Lung Cancer Radiotherapy Response and Correlate With Tumor Volume and Proliferation Imaging. Clin Lung Cancer. 2018;19:239-248.e7 pubmed publisher
    ..75-0.78). Chemotherapy (P < .001) and baseline keratinocyte growth factor (P = ...
  24. Mao X, Gauche C, Coughtrie M, Bui C, Gulberti S, Merhi Soussi F, et al. The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer. Oncogene. 2016;35:5043-55 pubmed publisher
  25. Park S, Kim D, Kim S, Lorz L, Choi E, Lim H, et al. Loliolide Presents Antiapoptosis and Antiscratching Effects in Human Keratinocytes. Int J Mol Sci. 2019;20: pubmed publisher
    ..growth factor receptor signaling pathway (PI3K, AKT) and migration factors, such as K6, K16, and K17; keratinocyte growth factor; and inflammatory cytokines, such as interleukin (IL)-1, IL-17, and IL-22 expressed during the cellular ..
  26. Uzunhan Y, Bernard O, Marchant D, Dard N, Vanneaux V, Larghero J, et al. Mesenchymal stem cells protect from hypoxia-induced alveolar epithelial-mesenchymal transition. Am J Physiol Lung Cell Mol Physiol. 2016;310:L439-51 pubmed publisher
    ..Finally, incubation with human recombinant KGF at a concentration similar to what was measured in hMSC-conditioned media restored the expression of TTF-1 and ..
  27. Colby J, Abdulnour R, Sham H, Dalli J, Colas R, Winkler J, et al. Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016;186:1801-1813 pubmed publisher
    ..Increases in lung epithelial cell proliferation and bronchoalveolar lavage fluid levels of keratinocyte growth factor were observed with AT-RvD3, which also promoted cutaneous re-epithelialization...
  28. Heer R, Collins A, Robson C, Shenton B, Leung H. KGF suppresses alpha2beta1 integrin function and promotes differentiation of the transient amplifying population in human prostatic epithelium. J Cell Sci. 2006;119:1416-24 pubmed
    ..b>Keratinocyte growth factor (KGF), a stromal-derived growth factor, has previously been implicated in prostate organogenesis using ..
  29. Tong T, Kim N, Park T. Topical Application of Oleuropein Induces Anagen Hair Growth in Telogen Mouse Skin. PLoS ONE. 2015;10:e0129578 pubmed publisher
    ..The oleuropein-treated mouse skin showed substantial upregulation of Wnt10b, FZDR1, LRP5, LEF1, Cyc-D1, IGF-1, KGF, HGF, and VEGF mRNA expression and β-catenin protein expression...
  30. Seo S, Kim C, Seo J, Kim D, Lee C. Does Superficial Medial Collateral Ligament Release in Open-Wedge High Tibial Osteotomy for Varus Osteoarthritic Knees Increase Valgus Laxity?. Am J Sports Med. 2016;44:908-15 pubmed publisher
    ..To assess the medial laxity of knee joint, medial joint space opening (MJO) was measured while valgus stress of 15 kgf was loaded on the knee joint...
  31. Kanzaki Y, Onoue F, Ishikawa F, Ide T. Telomerase rescues the expression levels of keratinocyte growth factor and insulin-like growth factor-II in senescent human fibroblasts. Exp Cell Res. 2002;279:321-9 pubmed
    ..The expression levels of KGF and IGF-II were decreased with proliferative aging but not by growth arrest of young cells...
  32. West D, Rees C, Duchesne L, Patey S, Terry C, Turnbull J, et al. Interactions of multiple heparin binding growth factors with neuropilin-1 and potentiation of the activity of fibroblast growth factor-2. J Biol Chem. 2005;280:13457-64 pubmed
    ..Npn-1 was also found to potentiate the growth stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins. ..
  33. Chen N, Hu Y, Li W, Eisinger M, Seiberg M, Lin C. The role of keratinocyte growth factor in melanogenesis: a possible mechanism for the initiation of solar lentigines. Exp Dermatol. 2010;19:865-72 pubmed publisher
    ..Ultraviolet B (UVB) stimulates keratinocytes to produce interlukin-1 alpha (IL-1?), which then induces keratinocyte growth factor (KGF) secretion; therefore, we examined their possible roles in the induction of SLs...
  34. Moore D, Hammer J, Akhtari R, Beck J, Sanders S, Kryscio R. Squeeze Me if You Can: Variability in Force Requirements to Extract a Drop From Common Glaucoma Bottles. J Glaucoma. 2016;25:780-4 pubmed publisher
    ..There was significant variability across the designs, with roughly a 7-fold (0.67 to 4.49 kgf) and 4-fold (0.81 to 3...
  35. Jampa Ngern S, Viravaidya Pasuwat K, Suvanasuthi S, Khantachawana A. Effect of laser diode light irradiation on growth capability of human hair follicle dermal papilla cells. Conf Proc IEEE Eng Med Biol Soc. 2017;2017:3592-3595 pubmed publisher
    ..5 J/cm2, and 1 J/cm2 light was used, while an increase in the level of fibroblast growth factor 7 (Fgf7) gene was observed with light irradiation at 0.5 J/cm2, 1 J/cm2, 2...
  36. Mahlapuu M, Enerback S, Carlsson P. Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations. Development. 2001;128:2397-406 pubmed
    ..Fibroblast growth factor (FGF) 10 and FGF7 both decrease Foxf1 expression and we speculate that this is mediated by transcriptional activation of epithelial ..
  37. Suyama Y, Kubota Y, Yamashiro T, Ninomiya T, Koji T, Shirasuna K. Expression of keratinocyte growth factor and its receptor in odontogenic keratocysts. J Oral Pathol Med. 2009;38:476-80 pubmed
    ..b>Keratinocyte growth factor (KGF) interacts with its specific receptor (KGFR), and elicits the proliferation and/or differentiation ..
  38. Jarosz M, Robbez Masson L, Chioni A, Cross B, Rosewell I, Grose R. Fibroblast growth factor 22 is not essential for skin development and repair but plays a role in tumorigenesis. PLoS ONE. 2012;7:e39436 pubmed publisher
    ..Of the 22 mammalian FGFs, FGF22, a member of the FGF7/10/22 subfamily, has been shown to have a clear role in synaptogenesis, but its roles in other tissues have not ..
  39. Jiang L, Zhang S, Dong C, Chen B, Feng J, Peng W, et al. Genome-wide identification, phylogeny, and expression of fibroblast growth genes in common carp. Gene. 2016;578:225-31 pubmed publisher
    ..genomes, we found that eight FGFs in common carp have undergone gene duplications, including FGF6a, FGF6b, FGF7, FGF8b, FGF10a, FGF11b, FGF13a, and FGF18b...
  40. Wood L, Blagojevic Bucknall M, Stynes S, D Cruz D, Mullis R, Whittle R, et al. Impairment-targeted exercises for older adults with knee pain: a proof-of-principle study (TargET-Knee-Pain). BMC Musculoskelet Disord. 2016;17:47 pubmed publisher
    ..9 KgF (95 % CI 0.1, 7.8). Changes in knee flexion ROM (2.1° (-2.3, 6.5)) and single-leg balance time (-2.4 s (-4.5, 6...
  41. Vasconcelos K, Dias J, Bastone A, Vieira R, Andrade A, Perracini M, et al. Handgrip Strength Cutoff Points to Identify Mobility Limitation in Community-dwelling Older People and Associated Factors. J Nutr Health Aging. 2016;20:306-15 pubmed publisher
    ..8 kgf for men (sensitivity 69%, specificity 73%) and 17.4 kgf (sensitivity 60%, specificity 66%) for women...
  42. Offiah I, Didangelos A, Dawes J, Cartwright R, Khullar V, Bradbury E, et al. The Expression of Inflammatory Mediators in Bladder Pain Syndrome. Eur Urol. 2016;70:283-90 pubmed publisher
    ..Analysis revealed 15 differentially expressed genes, confirmed in a replication study. FGF7 and CCL21 correlated significantly with clinical outcomes...
  43. de Bessa Garcia S, Pavanelli A, Cruz E Melo N, Nagai M. Prostate apoptosis response 4 (PAR4) expression modulates WNT signaling pathways in MCF7 breast cancer cells: A possible mechanism underlying PAR4-mediated docetaxel chemosensitivity. Int J Mol Med. 2017;39:809-818 pubmed publisher
    ..Upregulation of FGF7, LEF1 and TWIST1 indicated activation of the WNT/??catenin pathway...
  44. Turczyk L, Kitowska K, Mieszkowska M, Mieczkowski K, Czaplinska D, Piasecka D, et al. FGFR2-Driven Signaling Counteracts Tamoxifen Effect on ER?-Positive Breast Cancer Cells. Neoplasia. 2017;19:791-804 pubmed publisher
    ..of tamoxifen, FGFs (Fibroblast Growth Factors) promote BCa cell growth with the strongest effect being produced by FGF7. FGFR2 was identified as a mediator of FGF7 action and the FGFR2-induced signaling was found to underlie cancer-..
  45. Mattei M, Delapeyriere O, Bresnick J, Dickson C, Birnbaum D, Mason I. Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively. Mamm Genome. 1995;6:196-7 pubmed
  46. Narita K, Fujii T, Ishiwata T, Yamamoto T, Kawamoto Y, Kawahara K, et al. Keratinocyte growth factor induces vascular endothelial growth factor-A expression in colorectal cancer cells. Int J Oncol. 2009;34:355-60 pubmed
    b>Keratinocyte growth factor (KGF), which is also called fibroblast growth factor (FGF)-7, belongs to the FGF family...
  47. Panwar D, Rawal L, Sehgal N, Ali S. Cross Talk between KGF and KITLG Proteins Implicated with Ovarian Folliculogenesis in Buffalo Bubalus bubalis. PLoS ONE. 2015;10:e0127993 pubmed publisher
    Molecular interactions between mesenchymal-derived Keratinocyte growth factor (KGF) and Kit ligand (KITLG) are essential for follicular development. These factors are expressed by theca and granulosa cells...
  48. Hong L, Han Y, Liu J, Fan D. Keratinocyte growth factor receptor: a therapeutic target in solid cancer. Expert Opin Ther Targets. 2015;19:1411-8 pubmed publisher
    ..b>Keratinocyte growth factor receptor (KGFR) is a receptor tyrosine kinase that is primarily localized on epithelial cells...
  49. Yin J, Sheng B, Pu A, Han B, Yang K, Wang Q, et al. Keratinocyte Growth Factor Regulation of Aryl Hydrocarbon Receptor Activation in Colorectal Cancer Cells. Dig Dis Sci. 2016;61:444-52 pubmed publisher
    b>Keratinocyte growth factor (KGF) stimulates normal growth, development and intestinal epithelial cell proliferation. Cyclin D1 promotes the cell cycle by inhibiting retinoblastoma protein (RB1)...
  50. Jiang Y, Ju Z, Zhang J, Liu X, Tian J, Mu G. Effects of insulin-like growth factor 2 and its receptor expressions on corneal repair. Int J Clin Exp Pathol. 2015;8:10185-91 pubmed
    ..growth factor (EGF), fibroblast growth factor-β (FGF-β), heparin-like growth factor (HGF), keratinocyte growth factor (KGF), transforming growth factor-β1 (TGF-β1), IGF-1 and IGF-2...
  51. Wakame K, Okawa H, Komatsu K, Nakata A, Sato K, Ingawa H, et al. Immunopotentiator from Pantoea agglomerans 1 (IP-PA1) Promotes Murine Hair Growth and Human Dermal Papilla Cell Gene Expression. Anticancer Res. 2016;36:3687-92 pubmed
    ..05). An underlying mechanism of gene expression by which IP-PA1 promotes hair growth was suggested to be different from that of medicine and traditional hair tonics, such as minoxidil and adenosine. ..
  52. Devalliere J, Dooley K, Hu Y, Kelangi S, Uygun B, Yarmush M. Co-delivery of a growth factor and a tissue-protective molecule using elastin biopolymers accelerates wound healing in diabetic mice. Biomaterials. 2017;141:149-160 pubmed publisher
    ..Here, we re-engineered keratinocyte growth factor (KGF) and the cellular protective peptide ARA290 into a protein polymer suspension with the purpose of ..
  53. Belleudi F, Purpura V, Caputo S, Torrisi M. FGF7/KGF regulates autophagy in keratinocytes: A novel dual role in the induction of both assembly and turnover of autophagosomes. Autophagy. 2014;10:803-21 pubmed publisher
    ..Here we investigated the autophagic role of FGF7/KGF, an important player in epithelial cell protection and differentiation...
  54. Iwamoto U, Hori H, Takami Y, Tokushima Y, Shinzato M, Yasutake M, et al. A novel cell-containing device for regenerative medicine: biodegradable nonwoven filters with peripheral blood cells promote wound healing. J Artif Organs. 2015;18:315-21 pubmed publisher
    ..The m-PBCs captured on the PLA filters enhanced keratinocyte growth factor (FGF-7) and TGF-β1 productions in vitro, which may be related to wound healing...
  55. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..5 and E14.5. During this period, Fgf5, Fgf6, Fgf7, Fgf9, Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, ..
  56. Bi Z, Zhou Q, Geng Y, Zhang H. Human umbilical cord mesenchymal stem cells ameliorate experimental cirrhosis through activation of keratinocyte growth factor by suppressing microRNA-199. Eur Rev Med Pharmacol Sci. 2016;20:4905-4912 pubmed
    b>Keratinocyte growth factor (KGF) has a demonstrated role in the prevention of cirrhosis during liver regeneration...
  57. Spiry C, Bacle G, Marteau E, Charruau B, Laulan J. Radiocarpal dislocations and fracture-dislocations: Injury types and long-term outcomes. Orthop Traumatol Surg Res. 2018;104:261-266 pubmed publisher
    ..The good functional outcomes and absence of osteoarthritis can be attributed to the effective reduction and radiocarpal stabilization, along with the absence of radial and intracarpal marginal fractures. IV, retrospective. ..
  58. Yasuhara T, Okamoto A, Kitagawa T, Nikaido T, Yoshimura T, Yanaihara N, et al. FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer. Int J Oncol. 2005;26:1209-16 pubmed
    ..7-kb sequence, which contained the FGF7 [keratinocyte growth factor (KGF)]-like gene including exons 2 and 3. FISH analysis showed that the 57...
  59. Cardinali G, Bolasco G, Aspite N, Lucania G, Lotti L, Torrisi M, et al. Melanosome transfer promoted by keratinocyte growth factor in light and dark skin-derived keratinocytes. J Invest Dermatol. 2008;128:558-67 pubmed
    ..Among them, the keratinocyte growth factor (KGF/FGF7) promotes melanosome transfer acting on the recipient keratinocytes through stimulation of the ..
  60. Canady J, Arndt S, Karrer S, Bosserhoff A. Increased KGF expression promotes fibroblast activation in a double paracrine manner resulting in cutaneous fibrosis. J Invest Dermatol. 2013;133:647-657 pubmed publisher
    ..We examined keratinocyte growth factor (KGF), a crucial molecule in fibroblast-keratinocyte cross talk, exemplarily in keloid and scleroderma, ..
  61. Durak H, Atmaca S, Karayiğit M, Yarım M. Effect of Mitomycin C on bFGF, TGF-β1, KGF-1 Expressions after Myringotomy: An Animal Study. J Int Adv Otol. 2015;11:188-91 pubmed publisher
    ..expressions of transforming growth factor-β1 (TGF-β1), basic fibroblast growth factor (bFGF), and keratinocyte growth factor-1 (KGF-1) in TM epithelia, fibroblasts, and macrophages were performed by immunohistochemical staining ..
  62. Bernard O, Jeny F, Uzunhan Y, Dondi E, Terfous R, Label R, et al. Mesenchymal stem cells reduce hypoxia-induced apoptosis in alveolar epithelial cells by modulating HIF and ROS hypoxic signalings. Am J Physiol Lung Cell Mol Physiol. 2017;:ajplung.00153.2017 pubmed publisher
    ..The paracrine protective effect of hMSC was partly dependent on Keratinocyte Growth Factor and Hepatocyte Growth Factor secretion, preventing ROS and HIF-1? accumulation.
  63. Putnins E, Sanaie A, Wu Q, Firth J. Induction of keratinocyte growth factor 1 Expression by lipopolysaccharide is regulated by CD-14 and toll-like receptors 2 and 4. Infect Immun. 2002;70:6541-8 pubmed
    ..b>Keratinocyte growth factor 1, an epithelium-specific growth factor, is expressed by gingival fibroblasts, and its expression is ..
  64. Guo L, Degenstein L, Fuchs E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev. 1996;10:165-75 pubmed
    Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF7), is synthesized by skin fibroblasts. However, its mitogenic activity is on skin keratinocytes, where it is the most potent growth factor identified thus far...
  65. Graeff R, Wang G, McCray P. KGF and FGF-10 stimulate liquid secretion in human fetal lung. Pediatr Res. 1999;46:523-9 pubmed
    ..fetal lung liquid secretion are poorly understood; however, recent studies in murine models show that keratinocyte growth factor (KGF, FGF-7) and fibroblast growth factor 10 (FGF-10) stimulate liquid secretion...
  66. Parrott J, Kim G, Mosher R, Skinner M. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Mol Cell Endocrinol. 2000;167:77-87 pubmed
    The current study investigates the expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium (OSE) and ovarian cancer tissues. Ovarian tumors are primarily derived from the OSE...
  67. Kirfel G, Borm B, Rigort A, Herzog V. The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes. Eur J Cell Biol. 2002;81:664-76 pubmed
    ..the secretory N-terminal portion of the beta-amyloid precursor protein (sAPP) has been identified as a keratinocyte growth factor. Hence, in this study we analysed whether sAPP stimulates also keratinocyte migration employing the ..
  68. Grøn B, Stoltze K, Andersson A, Dabelsteen E. Oral fibroblasts produce more HGF and KGF than skin fibroblasts in response to co-culture with keratinocytes. APMIS. 2002;110:892-8 pubmed
    The production of hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) in subepithelial fibroblasts from buccal mucosa, periodontal ligament, and skin was determined after co-culture with keratinocytes...
  69. Hyland P, McKeown S, Mackenzie I, Irwin C. Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004;33:391-7 pubmed
    Epithelial proliferation is a histological characteristic of drug-induced gingival overgrowth. Keratinocyte growth factor (KGF) and scatter factor (SF) are fibroblast-derived growth factors with potent mitogenic and motogenic effects on ..
  70. Chang Y, Wang J, Lu X, Thewke D, Mason R. KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells. J Lipid Res. 2005;46:2624-35 pubmed
    Lipid synthesis is required for cell growth and is subject to pharmacologic regulation. Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a pulmonary epithelial cancer cell line, but the signaling ..
  71. Zheng C, Cotrim A, Sunshine A, Sugito T, Liu L, Sowers A, et al. Prevention of radiation-induced oral mucositis after adenoviral vector-mediated transfer of the keratinocyte growth factor cDNA to mouse submandibular glands. Clin Cancer Res. 2009;15:4641-8 pubmed publisher
    The study aims to evaluate if human keratinocyte growth factor (hKGF), secreted after transduction of murine salivary glands with adenoviral vectors, can prevent oral mucositis resulting from radiation...
  72. Aguilar S, Scotton C, McNulty K, Nye E, Stamp G, Laurent G, et al. Bone marrow stem cells expressing keratinocyte growth factor via an inducible lentivirus protects against bleomycin-induced pulmonary fibrosis. PLoS ONE. 2009;4:e8013 pubmed publisher
    ..b>Keratinocyte Growth Factor (KGF, also known as FGF-7) is a critical mediator of pulmonary epithelial repair through stimulation of ..
  73. Lin C, Hu Y, Rossetti D, Chen N, David C, Slominski A, et al. Immuno-histochemical evaluation of solar lentigines: The association of KGF/KGFR and other factors with lesion development. J Dermatol Sci. 2010;59:91-7 pubmed publisher
    ..Our earlier data show that keratinocyte growth factor (KGF) induces hyperpigmentary lesions with histological resemblance to SLs...
  74. Xu S, Kuang J, Liu J, Ma C, Feng Y, Su Z. Association between fibroblast growth factor 7 and the risk of chronic obstructive pulmonary disease. Acta Pharmacol Sin. 2012;33:998-1003 pubmed publisher
    b>Fibroblast growth factor 7 (FGF7) is involved in a number of physiological and pathological processes, including lung disease...
  75. Ishino R, Minami K, Tanaka S, Nagai M, Matsui K, Hasegawa N, et al. FGF7 supports hematopoietic stem and progenitor cells and niche-dependent myeloblastoma cells via autocrine action on bone marrow stromal cells in vitro. Biochem Biophys Res Commun. 2013;440:125-31 pubmed publisher
    ..In this study, we show that fibroblast growth factor (FGF7) may be a novel niche factor for HSPC support and leukemic growth...
  76. Xu H, Xu J, Zhang S, Zhu Q, Jin B, ZhuGe D, et al. Temperature-sensitive heparin-modified poloxamer hydrogel with affinity to KGF facilitate the morphologic and functional recovery of the injured rat uterus. Drug Deliv. 2017;24:867-881 pubmed publisher
    ..There is still lack of an effective therapeutic strategy to prevent occurrence of IUA. Keratinocyte growth factor (KGF) is a potent repair factor for epithelial tissues...
  77. Zhang C, Li L, Feng K, Fan D, Xue W, Lü J. 'Repair' Treg Cells in Tissue Injury. Cell Physiol Biochem. 2017;43:2155-2169 pubmed publisher
    ..Epidermal growth factor receptor, amphiregulin, CD73/CD39 and keratinocyte growth factor are important repair factors that are produced or expressed by repair Tregs; these factors coordinate ..
  78. Ito K, Hosoda K, Shimizu M, Ikemoto S, Nagura T, Seki H, et al. Three-dimensional innate mobility of the human foot bones under axial loading using biplane X-ray fluoroscopy. R Soc Open Sci. 2017;4:171086 pubmed publisher
    ..Five cadaver feet were axially loaded up to 588?N (60?kgf), and radiographic images were captured using a biplane X-ray fluoroscopy system...
  79. Izawa K, Kasahara Y, Hiraki K, Hirano Y, Watanabe S. Relation between the Disability of the Arm, Shoulder and Hand Score and Muscle Strength in Post-Cardiac Surgery Patients. Diseases. 2017;5: pubmed publisher
    ..5 ± 13.7%). Respective handgrip strength, knee extensor muscle strength, and DASH score were 27.4 ± 8.3 kgf, 1.6 ± 0.4 Nm/kg, and 13.3 ± 12.3, respectively...
  80. Kanai M, Rosenberg I, Podolsky D. Cytokine regulation of fibroblast growth factor receptor 3 IIIb in intestinal epithelial cells. Am J Physiol. 1997;272:G885-93 pubmed
    ..Regulated expression of FGFR3 IIIb was associated with acquisition of the differentiated state. Keratinocyte growth factor (KGF), a ligand of another member of the FGF receptor family, enhanced expression of FGFR3 IIIb, but ..
  81. Lu Y, Pan Z, Devaux Y, Ray P. p21-activated protein kinase 4 (PAK4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death. J Biol Chem. 2003;278:10374-80 pubmed
    b>Keratinocyte growth factor (KGF), a member of the fibroblast growth factor (FGF) family (also known as FGF-7), is an important protective factor for epithelial cells...
  82. Carpenter T, Ellis B, Insogna K, Philbrick W, Sterpka J, Shimkets R. Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors. J Clin Endocrinol Metab. 2005;90:1012-20 pubmed
    ..Testing of identified candidates revealed that one protein, fibroblast growth factor 7 (FGF7), was a potent and direct inhibitor of phosphate uptake in vitro...
  83. Marchand Adam S, Plantier L, Bernuau D, Legrand A, Cohen M, Marchal J, et al. Keratinocyte growth factor expression by fibroblasts in pulmonary fibrosis: poor response to interleukin-1beta. Am J Respir Cell Mol Biol. 2005;32:470-7 pubmed
    b>Keratinocyte growth factor (KGF) is secreted by fibroblasts and protects from pulmonary fibrosis in animal models. Interleukin (IL)-1beta is the most potent inducer of KGF in fibroblasts, acting through the c-Jun pathway...
  84. Kovacs D, Raffa S, Flori E, Aspite N, Briganti S, Cardinali G, et al. Keratinocyte growth factor down-regulates intracellular ROS production induced by UVB. J Dermatol Sci. 2009;54:106-13 pubmed publisher
    ..b>Keratinocyte growth factor (KGF/FGF7), a member of the fibroblast growth factor family, promotes epithelial growth and ..
  85. Sun Z, Yu X, Wu W, Jia D, Chen Y, Ji L, et al. Fibroblast growth factor 7 inhibits cholesterol 7?-hydroxylase gene expression in hepatocytes. Biochem Biophys Res Commun. 2012;423:775-80 pubmed publisher
    ..Transcription of the CYP7A1 gene is regulated by bile acids, nuclear receptors and cytokines. Fibroblast growth factor 7 (FGF7) secreted from activated hepatic stellate cells (HSC) during chronic liver fibrosis regulates ..
  86. Yokley B, Selby S, Posch P. A stimulation-dependent alternate core promoter links lymphotoxin ? expression with TGF-?1 and fibroblast growth factor-7 signaling in primary human T cells. J Immunol. 2013;190:4573-84 pubmed publisher
  87. Nakao Y, Mitsuyasu T, Kawano S, Nakamura N, Kanda S, Nakamura S. Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway. Int J Oncol. 2013;43:1377-84 pubmed publisher
    ..Fibroblast growth factor (FGF) 3, FGF7 and FGF10, which are expressed by the neural crest-derived ectomesenchymal cells, induce the proliferation of ..
  88. Jeon Y, Kook S, Rho S, Lim S, Choi K, Kim H, et al. Fibroblast growth factor-7 facilitates osteogenic differentiation of embryonic stem cells through the activation of ERK/Runx2 signaling. Mol Cell Biochem. 2013;382:37-45 pubmed publisher
    Fibroblast growth factor-7 (FGF7) is known to regulate proliferation and differentiation of cells; however, little information is available on how FGF7 affects the differentiation of embryonic stem cells (ESCs)...
  89. Zhang Q, Wang P, Shao M, Chen S, Xu Z, Xu F, et al. Clinicopathological correlation of keratinocyte growth factor and matrix metalloproteinase-9 expression in human gastric cancer. Tumori. 2015;101:566-71 pubmed publisher
    b>Keratinocyte growth factor (KGF) is reported to be implicated in the growth of some cancer cells. Matrix metalloproteinase 9 (MMP-9) is thought to enhance the tumor invasion and metastasis ability...
  90. Dial C, Tune M, Doerschuk C, Mock J. Foxp3+ Regulatory T Cell Expression of Keratinocyte Growth Factor Enhances Lung Epithelial Proliferation. Am J Respir Cell Mol Biol. 2017;57:162-173 pubmed publisher
    ..of Treg-specific expression of a growth factor that is known to be important in lung repair, keratinocyte growth factor (kgf)...
  91. Huang T, Wang L, Liu D, Li P, Xiong H, Zhuang L, et al. FGF7/FGFR2 signal promotes invasion and migration in human gastric cancer through upregulation of thrombospondin-1. Int J Oncol. 2017;50:1501-1512 pubmed publisher
    Fibroblast growth factor 7 (FGF7) is a mesenchyme-specific heparin-binding growth factor that binds FGF receptor 2 (FGFR2) to regulate numerous cellular and physiological processes...
  92. Winkles J, Alberts G, Chedid M, Taylor W, Demartino S, Rubin J. Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries. J Cell Physiol. 1997;173:380-6 pubmed
    b>Keratinocyte growth factor (KGF) is a secreted member of the fibroblast growth factor (FGF) family of heparin-binding proteins...