Gene Symbol: FGF3
Description: fibroblast growth factor 3
Alias: HBGF-3, INT2, fibroblast growth factor 3, FGF-3, INT-2 proto-oncogene protein, V-INT2 murine mammary tumor virus integration site oncogene homolog, fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog), heparin-binding growth factor 3, murine mammary tumor virus integration site 2, mouse, oncogene INT2, proto-oncogene Int-2
Species: human
Products:     FGF3

Top Publications

  1. Ramsebner R, Ludwig M, Parzefall T, Lucas T, Baumgartner W, Bodamer O, et al. A FGF3 mutation associated with differential inner ear malformation, microtia, and microdontia. Laryngoscope. 2010;120:359-64 pubmed publisher
    ..Auditory investigations, computer tomography, and genetic sequencing of the fibroblast growth factor 3 (FGF3) gene were performed on a Somali family presenting with autosomal recessive, hearing impairment, ..
  2. Mansour S, Goddard J, Capecchi M. Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. Development. 1993;117:13-28 pubmed
    ..Thus, we conclude that even in a uniform genetic background, stochastic variation in the expression of a developmental circuit can result in dramatic differences in phenotypic consequences. ..
  3. Ornitz D, Xu J, Colvin J, McEwen D, MacArthur C, Coulier F, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996;271:15292-7 pubmed
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways. ..
  4. Tekin M, Hişmi B, Fitoz S, Ozdag H, Cengiz F, Sirmaci A, et al. Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. Am J Hum Genet. 2007;80:338-44 pubmed
    ..We later demonstrated three different homozygous mutations (p.S156P, p.R104X, and p.V206SfsX117) in the fibroblast growth factor 3 (FGF3) gene in affected members of these families, cosegregating with the autosomal recessive ..
  5. Gregory Evans C, Moosajee M, Hodges M, Mackay D, Game L, Vargesson N, et al. SNP genome scanning localizes oto-dental syndrome to chromosome 11q13 and microdeletions at this locus implicate FGF3 in dental and inner-ear disease and FADD in ocular coloboma. Hum Mol Genet. 2007;16:2482-93 pubmed
    ..The smallest 43 kb deletion resulted in the loss of only one gene, FGF3, which was also deleted in all other otodental families...
  6. Tekin M, Ozturkmen Akay H, Fitoz S, Birnbaum S, Cengiz F, Sennaroglu L, et al. Homozygous FGF3 mutations result in congenital deafness with inner ear agenesis, microtia, and microdontia. Clin Genet. 2008;73:554-65 pubmed publisher
    Homozygous mutations in the fibroblast growth factor 3 (FGF3) gene have recently been discovered in an autosomal recessive form of syndromic deafness characterized by complete labyrinthine aplasia (Michel aplasia), microtia, and ..
  7. Alsmadi O, Meyer B, Alkuraya F, Wakil S, Alkayal F, Al Saud H, et al. Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3). Eur J Hum Genet. 2009;17:14-21 pubmed publisher
    We identified a homozygous missense mutation (c.196G-->T) in fibroblast growth factor 3 (FGF3) in 21 affected individuals from a large extended consanguineous Saudi family, phenotypically characterized by autosomal recessive syndromic ..
  8. Motta G, Amaral M, Rezende E, Pitta R, Vieira T, Duarte M, et al. Evidence of genetic variations associated with rotator cuff disease. J Shoulder Elbow Surg. 2014;23:227-35 pubmed publisher
    ..polymorphisms within 6 genes involved in repair and degenerative processes (DEFB1, DENND2C, ESRRB, FGF3, FGF10, and FGFR1) were investigated in 410 patients, 203 with a diagnosis of RCD and 207 presenting with absence ..
  9. Liu F, Pogoda H, Pearson C, Ohyama K, Löhr H, Hammerschmidt M, et al. Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis. Development. 2013;140:1111-22 pubmed publisher
    ..Using ex vivo analyses in chick and in vivo analyses in mutant and transgenic zebrafish, we show that Fgf10 and Fgf3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons...

More Information

Publications103 found, 100 shown here

  1. Padanad M, Bhat N, Guo B, Riley B. Conditions that influence the response to Fgf during otic placode induction. Dev Biol. 2012;364:1-10 pubmed publisher
    ..Using heat shock-inducible transgenes to misexpress Fgf3 or Fgf8 in zebrafish, we found that the stage, distribution and level of misexpression strongly influence the ..
  2. Hu Z, Zhang Q, Qin W, Tong J, Zhao Q, Han Y, et al. Gene miles-apart is required for formation of otic vesicle and hair cells in zebrafish. Cell Death Dis. 2013;4:e900 pubmed publisher
    ..Miles-apart (Mil) dysregulation also caused abnormal expression of hearing-associated genes, including hmx2, fgf3, fgf8a, foxi1, otop1, pax2.1 and tmieb during zebrafish organogenesis...
  3. McCarroll M, Nechiporuk A. Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PLoS ONE. 2013;8:e85087 pubmed publisher
    ..We discovered that two Fgf ligands, Fgf3 and Fgf10a, cooperate to promote EB placode development...
  4. Sweet E, Vemaraju S, Riley B. Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear. Dev Biol. 2011;358:113-21 pubmed publisher
    ..However, co-misexpression of atoh1a with fgf3, fgf8 or sox2, genes normally acting in the same gene network with atoh1a, stimulated sensory development in all ..
  5. Maulding K, Padanad M, Dong J, Riley B. Mesodermal Fgf10b cooperates with other fibroblast growth factors during induction of otic and epibranchial placodes in zebrafish. Dev Dyn. 2014;243:1275-85 pubmed publisher
    ..is known about epibranchial induction, the process of otic induction in highly conserved, with important roles for Fgf3 and Fgf8 reported in all species examined...
  6. Choe S, Zhang X, Hirsch N, Straubhaar J, SAGERSTROM C. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Dev Biol. 2011;358:356-67 pubmed publisher
    ..Furthermore, ppp1r14al is essential for establishment of the earliest hindbrain signaling-center in rhombomere 4 by regulating expression of fgf3.
  7. Zheng M, Li Y, Jiang B, Tu H, Tang W, Yang J, et al. Clinical Utility of Cerebrospinal Fluid Cell-Free DNA as Liquid Biopsy for Leptomeningeal Metastases in ALK-Rearranged NSCLC. J Thorac Oncol. 2019;14:924-932 pubmed publisher
    ..Multiple copy number variants were mainly found in CSF, including in EGFR, cyclin D1 gene (CCND1), fibroblast growth factor 3 gene (FGF3), and fibroblast growth factor 4 gene (FGF4)...
  8. Miyake A, Chitose T, Kamei E, Murakami A, Nakayama Y, Konishi M, et al. Fgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain. PLoS ONE. 2014;9:e110836 pubmed publisher
    ..of fgf16 in the forebrain was down-regulated by the inhibition of Hh and Fgf19 signaling, but not by that of Fgf3/Fgf8 signaling...
  9. Urness L, Wang X, Doan H, Shumway N, Noyes C, Gutierrez Magana E, et al. Spatial and temporal inhibition of FGFR2b ligands reveals continuous requirements and novel targets in mouse inner ear morphogenesis. Development. 2018;145: pubmed publisher
    ..The FGFR2b ligands FGF3 and FGF10 are expressed throughout otic development and are required individually for normal morphogenesis, but ..
  10. Vieira A, D Souza R, Mues G, Deeley K, Hsin H, Küchler E, et al. Candidate gene studies in hypodontia suggest role for FGF3. Eur Arch Paediatr Dent. 2013;14:405-10 pubmed publisher
    ..In the Turkish cohort (n = 51 parent-affected child trios) the most significant results were as follows: FGF3 rs1893047, p = 0.08; GLI3 rs929387, p = 0.03; GLI3 haplotype rs929387-rs846266, p = 0...
  11. Divya S, Hatha A. Screening of tropical estuarine water in south-west coast of India reveals emergence of ARGs-harboring hypervirulent Escherichia coli of global significance. Int J Hyg Environ Health. 2019;222:235-248 pubmed publisher
    ..blaCTX-M, tetA, tetB, sul1, sul2, strA, aphA2, catI, dhfr1, and dhfr7), integrase (int1, int2, and int3), Shiga toxin genes (stx1 and stx2) and extraintestinal virulence genes (papAH, papC, sfa/focDE, kpsMT II,..
  12. Singh A, Tekin M, Falcone M, Kapoor S. Delayed presentation of rickets in a child with labyrinthine aplasia, microtia and microdontia (LAMM) syndrome. Indian Pediatr. 2014;51:919-20 pubmed
    ..Homozygous novel missense mutation in fibroblast growth factor 3. LAMM syndrome and hypophosphatemic rickets may be associated.
  13. Goldshmit Y, Tang J, Siegel A, Nguyen P, Kaslin J, Currie P, et al. Different Fgfs have distinct roles in regulating neurogenesis after spinal cord injury in zebrafish. Neural Dev. 2018;13:24 pubmed publisher
    ..b>Fgf3 drives neurogenesis of Islet1 expressing motor neuron subtypes and mediate axonogenesis in cMet expressing motor ..
  14. Findlay J, Middleton M, Tomlinson I. A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. Ann Oncol. 2015;26:624-44 pubmed publisher
    ..associations were seen for six tumor variants (mutant TP53 and PIK3CA, copy number gain of ERBB2/HER2, CCND1 and FGF3, and chromosomal instability/ploidy) and seven germline polymorphisms: ERCC1 rs3212986, ERCC2 rs1799793, TP53 ..
  15. Parker Manuel R, Grevelding C, Gelmedin V. Cryptic 3' mRNA processing signals hinder the expression of Schistosoma mansoni integrins in yeast. Mol Biochem Parasitol. 2015;199:51-7 pubmed publisher
    ..by a stronger promoter, this enabled Smα-Int1 to be expressed as well, but the remaining integrins, Smα-Int2-4, still could not be expressed...
  16. Yadetie F, Zhang X, Hanna E, Aranguren Abadía L, Eide M, Blaser N, et al. RNA-Seq analysis of transcriptome responses in Atlantic cod (Gadus morhua) precision-cut liver slices exposed to benzo[a]pyrene and 17?-ethynylestradiol. Aquat Toxicol. 2018;201:174-186 pubmed publisher
    ..Interestingly, two genes coding for fibroblast growth factor 3 (Fgf3) and fibroblast growth factor 4 (Fgf4) were up-regulated by EE2 in this study...
  17. Huang D, Bastani A, Anderson W, Crabtree J, Kleiman S, Jones S. Communication and bed reservation: Decreasing the length of stay for emergency department trauma patients. Am J Emerg Med. 2018;36:1874-1879 pubmed publisher
    ..Second, a bed intervention [INT2], which reserved two temporary beds for trauma patients, was added...
  18. Rashid H, Ma C, Chen H, Wang H, Hassan M, Sinha K, et al. Sp7 and Runx2 molecular complex synergistically regulate expression of target genes. Connect Tissue Res. 2014;55 Suppl 1:83-7 pubmed publisher
    ..We selected promoters of osteocalcin (OC), a marker of mature osteoblast and fibroblast growth factor 3 (FGF3), a signaling molecule that determine the fate of embryonic ecto-mesenchyme...
  19. Lee Y, Gajdosik M, Josic D, Clifton J, Logothetis C, Yu Lee L, et al. Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment. Mol Cell Proteomics. 2015;14:471-83 pubmed publisher
    ..conditioned media of isolated PCa-118b tumor cells, and identified 26 secretory proteins, such as TGF-β2, GDF15, FGF3, FGF19, CXCL1, galectins, and β2-microglobulin, which represent both novel and previously published secreted ..
  20. Wu B, Wen S, Hwang S, Huang C, Kuan Y. Control of Wnt5b secretion by Wntless modulates chondrogenic cell proliferation through fine-tuning fgf3 expression. J Cell Sci. 2015;128:2328-39 pubmed publisher
    ..Here, we investigated the Wnt-mediated craniofacial cartilage development in zebrafish and found that fgf3 expression in the pharyngeal pouches is differentially reduced along the anteroposterior axis in wnt5b mutants and ..
  21. Bhowmick T, Kirn T, Hetherington F, Takavarasha S, Sandhu S, Gandhi S, et al. Collaboration between an antimicrobial stewardship team and the microbiology laboratory can shorten time to directed antibiotic therapy for methicillin-susceptible staphylococcal bacteremia and to discontinuation of antibiotics for coagulase-negative. Diagn Microbiol Infect Dis. 2018;92:214-219 pubmed publisher
    ..introduced rapid phenotypic identification and direct susceptibility testing (INT1), later replaced by PCR (INT2)...
  22. Worst T, Weis C, Stöhr R, Bertz S, Eckstein M, Otto W, et al. CDKN2A as transcriptomic marker for muscle-invasive bladder cancer risk stratification and therapy decision-making. Sci Rep. 2018;8:14383 pubmed publisher
    ..are described as progression markers of non-muscle invasive bladder cancer and to be associated with fibroblast growth factor 3 (FGFR3) mutations...
  23. Xiao L, Kumazawa Y, Okamura H. Cell death, cavitation and spontaneous multi-differentiation of dental pulp stem cells-derived spheroids in vitro: a journey to survival and organogenesis. Biol Cell. 2014;106:405-19 pubmed publisher
    ..Marker analysis showed that cavitation-related molecules BMP7 and FGF3 expressed on the wall of the cavity in the spheroids, suggesting that the cavitation was functional, whereas ..
  24. Chao W, Zhang Y, Chai L, Wang H. Transcriptomics provides mechanistic indicators of fluoride toxicology on endochondral ossification in the hind limb of Bufo gargarizans. Aquat Toxicol. 2018;201:138-150 pubmed publisher
    ..Besides, 10?mg F/L treatment could down-regulate Ihh, Sox9, D2, D3, TR?, TR?, Wnt10, FGF3 and BMP6 expression, while up-regulate ObRb and HHAT mRNA expression in the hind limb of B. gargarizans...
  25. McCullough K, Daskalakis N, Gafford G, Morrison F, Ressler K. Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction. Transl Psychiatry. 2018;8:164 pubmed publisher
    ..Differentially expressed transcripts with potentially targetable gene products include Npy5r, Rxrg, Adora2a, Sst5r, Fgf3, Erbb4, Fkbp14, Dlk1, and Ssh3...
  26. Li L, Guo C, Fan S, Lv J, Zhang Y, Xu Y, et al. Dynamic transport of antibiotics and antibiotic resistance genes under different treatment processes in a typical pharmaceutical wastewater treatment plant. Environ Sci Pollut Res Int. 2018;25:30191-30198 pubmed publisher
    ..resistance genes (ARGs) (tetB, tetW, sul1, sul2, gyrA, qepA, ermB, and ermF), and two mobile elements (int1 and int2) were investigated in a typical pharmaceutical plant...
  27. Schulze K, Imbeaud S, Letouzé E, Alexandrov L, Calderaro J, Rebouissou S, et al. Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets. Nat Genet. 2015;47:505-511 pubmed publisher
    ..Analyses according to tumor stage progression identified TERT promoter mutation as an early event, whereas FGF3, FGF4, FGF19 or CCND1 amplification and TP53 and CDKN2A alterations appeared at more advanced stages in aggressive ..
  28. Xu R, Chen W, Zhang Z, Qiu Y, Wang Y, Zhang B, et al. Integrated data analysis identifies potential inducers and pathways during the endothelial differentiation of bone-marrow stromal cells by DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine. Gene. 2018;657:9-18 pubmed publisher
    ..VEGFA, ANGPT2, FGF2, FGF9 and ETS1) which were directly upregulated by 5-aza-dC and five indirect factors (FGF1, FGF3, ETS2, ETV1 and ETV4) were identified...
  29. Teerlink C, Cannon Albright L, Tashjian R. Significant association of full-thickness rotator cuff tears and estrogen-related receptor-β (ESRRB). J Shoulder Elbow Surg. 2015;24:e31-5 pubmed publisher
    ..Model Association (GEMMA) software at 69 SNPs that fell within 20 kb of 6 candidate genes (DEFB1, DENND2C, ESRRB, FGF3, FGF10, and FGFR1)...
  30. Soria J, DeBraud F, Bahleda R, Adamo B, Andre F, Dienstmann R, et al. Phase I/IIa study evaluating the safety, efficacy, pharmacokinetics, and pharmacodynamics of lucitanib in advanced solid tumors. Ann Oncol. 2014;25:2244-51 pubmed publisher
    ..There are no approved drugs for molecularly defined FGF-aberrant (FGFR1- or FGF3/4/19-amplified) tumors...
  31. Kwon H, Park E, Jia S, Liu H, Lan Y, Jiang R. Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice. J Dent Res. 2015;94:1113-9 pubmed publisher
    ..the Msx1 and Runx2 transcription factors are required for activation of odontogenic signals, including Bmp4 and Fgf3, in the early tooth mesenchyme to drive tooth morphogenesis through the bud-to-cap transition and that Runx2 acts ..
  32. Koo S, Hill J, Hwang C, Lin Z, Millen K, Wu D. Lmx1a maintains proper neurogenic, sensory, and non-sensory domains in the mammalian inner ear. Dev Biol. 2009;333:14-25 pubmed publisher
    ..most likely disrupted as well, based on the increased numbers of vestibular neuroblasts and ectopic expression of Fgf3, which normally is associated specifically with the vestibular neurogenic region...
  33. Yamada T, Abei M, Danjoh I, Shirota R, Yamashita T, Hyodo I, et al. Identification of a unique hepatocellular carcinoma line, Li-7, with CD13(+) cancer stem cells hierarchy and population change upon its differentiation during culture and effects of sorafenib. BMC Cancer. 2015;15:260 pubmed publisher
    ..selectively targeted the CD166(-) fraction, including CD13(+) CSCs, which exhibited higher mRNA expression for FGF3 and FGF4, candidate biomarkers for sorafenib...
  34. Urness L, Wang X, Shibata S, Ohyama T, Mansour S. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015;400:59-71 pubmed publisher
    ..Fgf10, in addition to Fgf3, is necessary for the earliest stage of otic placode induction, but continued expression of Fgf10 in the developing ..
  35. Natarajan M, Kumar D, Mandal J, Biswal N, Stephen S. A study of virulence and antimicrobial resistance pattern in diarrhoeagenic Escherichia coli isolated from diarrhoeal stool specimens from children and adults in a tertiary hospital, Puducherry, India. J Health Popul Nutr. 2018;37:17 pubmed publisher
    ..None harbored qnrA, qnrC, qepA, tetE, tetC, tetY, ermA, mcr1, int2, and int3 genes...
  36. Koch P, Löhr H, Driever W. A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons. PLoS ONE. 2014;9:e113829 pubmed publisher
    ..dopaminergic differentiation, mRNA levels for several components of the FGF signaling pathway, including Fgf3, FGF receptors, and FGF target genes, are increased...
  37. Salem M, Puccini A, Xiu J, Raghavan D, Lenz H, Korn W, et al. Comparative Molecular Analyses of Esophageal Squamous Cell Carcinoma, Esophageal Adenocarcinoma, and Gastric Adenocarcinoma. Oncologist. 2018;23:1319-1327 pubmed publisher
    ..7% vs. 7.5% vs. 7.7%, p < .0001). We observed that FGF3, FGF4, FGF19, CCND1 (co-localized on 11q13), and FGFR1 were significantly more ..
  38. Tan Q, Li F, Wang G, Xia W, Li Z, Niu X, et al. Identification of FGF19 as a prognostic marker and potential driver gene of lung squamous cell carcinomas in Chinese smoking patients. Oncotarget. 2016;7:18394-402 pubmed publisher
    ..Importantly, an amplification region containing FGF19, FGF3, FGF4 and CCND1 was found five-times more frequent in S-LSCC than in NS-LSCC...
  39. Dabija D, Gao C, Edwards T, Kuhn J, Jain N. Genetic and familial predisposition to rotator cuff disease: a systematic review. J Shoulder Elbow Surg. 2017;26:1103-1112 pubmed publisher
    ..predisposition to rotator cuff disease exists and found significant association of haplotypes in DEFB1, FGFR1, FGF3, ESRRB, and FGF10 and 2 single-nucleotide polymorphisms within SAP30BP and SASH1...
  40. Yoo C, Kang J, Kim D, Kim K, Ryoo B, Hong S, et al. Multiplexed gene expression profiling identifies the FGFR4 pathway as a novel biomarker in intrahepatic cholangiocarcinoma. Oncotarget. 2017;8:38592-38601 pubmed publisher
    ..This included 10 FGF pathway genes (e.g. FGFR1-4, KLB, FGF3, 4, 19, 21, and 23), 19 distal marker genes (e.g. CYP7A1 and CYP17A1), 31 genes relevant to HCC and iCCA (e.g...
  41. Li Y, Sun C, Yates E, Jiang C, Wilkinson M, Fernig D. Heparin binding preference and structures in the fibroblast growth factor family parallel their evolutionary diversification. Open Biol. 2016;6: pubmed publisher
    ..Here, we measure the binding preferences of six FGFs (FGF3, FGF4, FGF6, FGF10, FGF17, FGF20) for a library of modified heparins, representing structures in HS, and model ..
  42. Chen J, Wei X, Liu Y, Ying G, Liu S, He L, et al. Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands: Optimization of wetland substrates and hydraulic loading. Sci Total Environ. 2016;565:240-248 pubmed publisher
    ..and qnrS) and four chloramphenicol resistance genes (cmlA, fexA, fexB and floR)) and two integrase genes (int1 and int2) were positively detected in the domestic wastewaters...
  43. Yoshida H, Okada M, Takebayashi Suzuki K, Ueno N, Suzuki A. Involvement of JunB Proto-Oncogene in Tail Formation During Early Xenopus Embryogenesis. Zoolog Sci. 2016;33:282-9 pubmed publisher
    ..of Xenopus embryos, overexpression of JunB increased the expression of tailbud and posterior marker genes including fgf3, xbra (t) and wnt8...
  44. Kaibori M, Sakai K, Ishizaki M, Matsushima H, De Velasco M, Matsui K, et al. Increased FGF19 copy number is frequently detected in hepatocellular carcinoma with a complete response after sorafenib treatment. Oncotarget. 2016;7:49091-49098 pubmed publisher
    ..We previously reported that fibroblast growth factor 3 and 4 (FGF3/FGF4) amplification is a predictor of a response to sorafenib...
  45. Coelho R, Gonçalves R, Villas Boas R, Bonato L, Quinelato V, Pinheiro A, et al. Haplotypes in BMP4 and FGF Genes Increase the Risk of Peri-Implantitis. Braz Dent J. 2016;27:367-74 pubmed publisher
    ..The aim of this study was to analyze the correlation between BMP4, FGF3, FGF10 and FGFR1 genes and peri-implant bone loss...
  46. Dos Santos Í, Jorge E, Copola A, Bertassoli B, Góes A, Silva G. FGF2, FGF3 and FGF4 expression pattern during molars odontogenesis in Didelphis albiventris. Acta Histochem. 2017;119:129-141 pubmed publisher
    ..postnatals were used to characterize the main stages of their molars development; and also to establish FGF2, FGF3 and FGF4 expression pattern. D...
  47. Olaya Sánchez D, Sánchez Guardado L, Ohta S, Chapman S, Schoenwolf G, Puelles L, et al. Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear. Brain Struct Funct. 2017;222:131-149 pubmed publisher
    ..b>FGF3 and FGF16 are excellent candidates to govern these developmental events...
  48. Patikas D, Mersmann F, Bohm S, Schroll A, Marzilger R, Arampatzis A. Soleus H-reflex modulation during balance recovery after forward falling. Muscle Nerve. 2016;54:952-958 pubmed publisher
    ..force at 15% and 30% of body weight, respectively), with no release (Int0) and at 2 different intervals (Int1, Int2) after the release (?45 and ?65 ms, respectively)...
  49. Shibata E, Yokota Y, Horita N, Kudo A, Abe G, Kawakami K, et al. Fgf signalling controls diverse aspects of fin regeneration. Development. 2016;143:2920-9 pubmed publisher
    ..Here, we performed comprehensive expression analyses and identified fgf20a and fgf3/10a as major Fgf ligands in the wound epidermis and blastema, respectively...
  50. Guffanti F, Chilà R, Bello E, Zucchetti M, Zangarini M, Ceriani L, et al. In Vitro and In Vivo Activity of Lucitanib in FGFR1/2 Amplified or Mutated Cancer Models. Neoplasia. 2017;19:35-42 pubmed publisher
    ..activity in a phase I/II clinical study, with objective RECIST responses in breast cancer patients with FGFR1 or FGF3/4/19 gene amplification, as well as in patients anticipated to benefit from anti-angiogenic agents...
  51. Anderson M, Southon E, Tessarollo L, Lewandoski M. Fgf3-Fgf4-cis: A new mouse line for studying Fgf functions during mouse development. Genesis. 2016;54:91-8 pubmed publisher
    ..Such analysis has revealed that multiple Fgfs sometimes function redundantly. Exploring such redundancy between Fgf3 and Fgf4 is currently impossible because both genes are located on chromosome 7, about 18...
  52. Zhang Y, Hu J, Zhang J, Zhou X, Li X, Gu C, et al. Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia. Nat Commun. 2016;7:10605 pubmed publisher
    ..The above 13 associated loci, harboured by candidates of ROBO1, GATA3, GBX2, FGF3, NRP2, EDNRB, SHROOM3, SEMA7A, PLCD3, KLF12 and EPAS1, are found to be enriched for genes involved in neural crest ..
  53. Anderson M, Schimmang T, Lewandoski M. An FGF3-BMP Signaling Axis Regulates Caudal Neural Tube Closure, Neural Crest Specification and Anterior-Posterior Axis Extension. PLoS Genet. 2016;12:e1006018 pubmed publisher
    ..Here, we analyze the posterior axis truncation of mouse Fgf3 null homozygotes and demonstrate that the earliest role of PSM-derived FGF3 is to regulate BMP signals in the ..
  54. Javle M, Churi C, Kang H, Shroff R, Janku F, Surapaneni R, et al. HER2/neu-directed therapy for biliary tract cancer. J Hematol Oncol. 2015;8:58 pubmed publisher
    ..One patient developed HER2/neu amplification as a secondary event after FGFR-directed therapy for FGF3-TACC3 gene fusion...
  55. Rataj Baniowska M, Niewiadomska Cimicka A, Paschaki M, Szyszka Niagolov M, Carramolino L, Torres M, et al. Retinoic Acid Receptor β Controls Development of Striatonigral Projection Neurons through FGF-Dependent and Meis1-Dependent Mechanisms. J Neurosci. 2015;35:14467-75 pubmed publisher
    ..Reduced expression of Fgf3 in the subventricular zone of the lateral ganglionic eminence (LGE) at embryonic day 13...
  56. Ross J, Gay L, Nozad S, Wang K, Ali S, Boguniewicz A, et al. Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study. Breast Cancer Res Treat. 2016;155:405-13 pubmed publisher
    ..005). Other frequently altered genes of interest in pmucBC were CCND1 and the FGF3/FGF4/FGF19 amplicon (27 %), often co-amplified together...
  57. Rubbini D, Robert Moreno Ã, Hoijman E, Alsina B. Retinoic Acid Signaling Mediates Hair Cell Regeneration by Repressing p27kip and sox2 in Supporting Cells. J Neurosci. 2015;35:15752-66 pubmed publisher
    ..Moreover, in neuromast, RA pathway regulates the transcription of p27(kip) and sox2 in supporting cells but not fgf3. Finally, genetic cell-lineage tracing using Kaede photoconversion demonstrates that de novo hair cells derive from ..
  58. Goedert L, Pereira C, Roszik J, Plaça J, Cardoso C, Chen G, et al. RMEL3, a novel BRAFV600E-associated long noncoding RNA, is required for MAPK and PI3K signaling in melanoma. Oncotarget. 2016;7:36711-36718 pubmed publisher
    ..RMEL3 knockdown led to downregulation of activators or effectors of these pathways, including FGF2, FGF3, DUSP6, ITGB3 and GNG2...
  59. Hanker A, Garrett J, Estrada M, Moore P, Ericsson P, Koch J, et al. HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2. Clin Cancer Res. 2017;23:4323-4334 pubmed publisher
    ..b>Results: LTR tumors exhibited an increase in FGF3/4/19 copy number, together with an increase in FGFR phosphorylation, marked stromal changes in the tumor ..
  60. Casey G, Smith R, McGillivray D, Peters G, Dickson C. Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene. Mol Cell Biol. 1986;6:502-10 pubmed
    ..By a combination of in situ hybridization of metaphase chromosomes and somatic cell genetics, the human int-2 gene was mapped to chromosome 11, band q13. ..
  61. Moffa A, Ethier S. Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. J Cell Physiol. 2007;210:720-31 pubmed
    ..We therefore conclude that aberrant expression of alternatively spliced isoforms of FGFR2 with the C3 carboxyl terminus in the SUM-52 breast cancer cells results in sustained activation of signal transduction leading to transformation. ..
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    ..Binding of the Grb2/Sos complex to phosphorylated Shc and pp90 may therefore be the key link between FGFR1 and the Ras signaling pathway, mito-genesis, and neuronal differentiation. ..
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    ..Here, we report that alterations in dosage of the Fgf3 gene cause morphological changes in both genetically engineered mutant mice and in human patients...
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    Recessive mutations of fibroblast growth factor 3 (FGF3) can cause LAMM syndrome (OMIM 610706), characterized by fully penetrant complete labyrinthine aplasia, microtia and microdontia...
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