FGF19

Summary

Gene Symbol: FGF19
Description: fibroblast growth factor 19
Alias: fibroblast growth factor 19, FGF-19
Species: human
Products:     FGF19

Top Publications

  1. Lin B, Wang M, Blackmore C, Desnoyers L. Liver-specific activities of FGF19 require Klotho beta. J Biol Chem. 2007;282:27277-84 pubmed
    ..b>FGF19 regulates bile acid homeostasis and gall bladder filling; FGF19 binds only to FGF receptor 4 (FGFR4), but its ..
  2. Katoh M, Katoh M. Evolutionary conservation of CCND1-ORAOV1-FGF19-FGF4 locus from zebrafish to human. Int J Mol Med. 2003;12:45-50 pubmed
    The CCND1-ORAOV1-FGF19-FGF4-FGF3-FLJ10261-FADD-PPFIA1-EMS1 locus on human chromosome 11q13 is frequently amplified in esophageal cancer, breast cancer, and bladder tumors...
  3. Wu X, Ge H, Lemon B, Vonderfecht S, Weiszmann J, Hecht R, et al. FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J Biol Chem. 2010;285:5165-70 pubmed publisher
    b>FGF19 and FGF21, unique members of the fibroblast growth factor (FGF) family, are hormones that regulate glucose, lipid, and energy homeostasis...
  4. Xie M, Holcomb I, Deuel B, Dowd P, Huang A, Vagts A, et al. FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4. Cytokine. 1999;11:729-35 pubmed
    ..FGF-19 message is expressed in several tissues including fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line. ..
  5. Mraz M, Lacinova Z, Kavalkova P, Haluzikova D, Trachta P, Drapalova J, et al. Serum concentrations of fibroblast growth factor 19 in patients with obesity and type 2 diabetes mellitus: the influence of acute hyperinsulinemia, very-low calorie diet and PPAR-? agonist treatment. Physiol Res. 2011;60:627-36 pubmed
    The aim of our study was to measure serum concentrations of fibroblast growth factor 19 (FGF-19) in patients with obesity (OB), obesity and type 2 diabetes mellitus (T2DM) and healthy subjects (C) at baseline and after selected ..
  6. Jansen P, van Werven J, Aarts E, Berends F, Janssen I, Stoker J, et al. Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery. Dig Dis. 2011;29:48-51 pubmed publisher
    ..the serum bile salts were slightly but significantly elevated, and the levels of the endocrine-acting fibroblast growth factor 19 (FGF19) and FGF21 were increased...
  7. Schreuder T, Marsman H, Lenicek M, van Werven J, Nederveen A, Jansen P, et al. The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. Am J Physiol Gastrointest Liver Physiol. 2010;298:G440-5 pubmed publisher
    Intestinal FGF19 has emerged as a novel endocrine regulator of hepatic bile salt and lipid metabolism. In patients with nonalcoholic fatty liver disease (NAFLD) hepatic lipid metabolism is deranged...
  8. Song K, Li T, Owsley E, Strom S, Chiang J. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology. 2009;49:297-305 pubmed publisher
    Mouse fibroblast growth factor 15 (FGF15) and human ortholog FGF19 have been identified as the bile acid-induced intestinal factors that mediate bile acid feedback inhibition of cholesterol 7alpha-hydroxylase gene (C YP7A1) transcription ..
  9. Tomlinson E, Fu L, John L, Hultgren B, Huang X, Renz M, et al. Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology. 2002;143:1741-7 pubmed
    ..The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4...

More Information

Publications100

  1. Holt J, Luo G, Billin A, Bisi J, McNeill Y, Kozarsky K, et al. Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis. Genes Dev. 2003;17:1581-91 pubmed
    ..This signaling cascade defines a novel mechanism for feedback repression of bile acid biosynthesis and underscores the vital role of FXR in the regulation of multiple pathways of cholesterol catabolism in the liver. ..
  2. Bhatnagar S, Damron H, Hillgartner F. Fibroblast growth factor-19, a novel factor that inhibits hepatic fatty acid synthesis. J Biol Chem. 2009;284:10023-33 pubmed publisher
    ..In summary, the inhibitory effect of FGF-19 on insulin activation of hepatic fatty acid synthesis constitutes a mechanism that would explain the beneficial effect of FGF-19 on metabolic syndrome. ..
  3. Fu L, John L, Adams S, Yu X, Tomlinson E, Renz M, et al. Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology. 2004;145:2594-603 pubmed
    ..In mice fed a high-fat diet, human fibroblast growth factor 19 (FGF19) increased metabolic rate [1.53 +/- 0.06 liters O(2)/h.kg(0.75) (vehicle) vs. 1.93 +/- 0...
  4. Barutcuoglu B, Basol G, Cakir Y, Cetinkalp S, Parildar Z, Kabaroglu C, et al. Fibroblast growth factor-19 levels in type 2 diabetic patients with metabolic syndrome. Ann Clin Lab Sci. 2011;41:390-6 pubmed
    ..The negative relationship between FGF-19 and several known cardiovascular risk factors such as TG, log (TG/HDL-c), hsCRP and HbA1c in diabetic patients with MetS suggests that FGF-19 can be used as a contributing marker. ..
  5. Dostalova I, Kaválková P, Haluzikova D, Lacinova Z, Mraz M, Papezova H, et al. Plasma concentrations of fibroblast growth factors 19 and 21 in patients with anorexia nervosa. J Clin Endocrinol Metab. 2008;93:3627-32 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19) and FGF21 are novel metabolic regulators that improve insulin sensitivity and decrease adiposity in mice. However, little is known about the nutritional regulation of these factors in humans...
  6. Wu X, Lemon B, Li X, Gupte J, Weiszmann J, Stevens J, et al. C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors. J Biol Chem. 2008;283:33304-9 pubmed publisher
    b>FGF19 subfamily proteins (FGF19, FGF21, and FGF23) are unique members of fibroblast growth factors (FGFs) that regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis in an endocrine fashion...
  7. Kurosu H, Choi M, Ogawa Y, Dickson A, Goetz R, Eliseenkova A, et al. Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007;282:26687-95 pubmed
    The fibroblast growth factor (FGF) 19 subfamily of ligands, FGF19, FGF21, and FGF23, function as hormones that regulate bile acid, fatty acid, glucose, and phosphate metabolism in target organs through activating FGF receptors (FGFR1-4)...
  8. Wu X, Ge H, Gupte J, Weiszmann J, Shimamoto G, Stevens J, et al. Co-receptor requirements for fibroblast growth factor-19 signaling. J Biol Chem. 2007;282:29069-72 pubmed
    b>FGF19 is a unique member of the fibroblast growth factor (FGF) family of secreted proteins that regulates bile acid homeostasis and metabolic state in an endocrine fashion...
  9. Zhou M, Wang X, Phung V, Lindhout D, Mondal K, Hsu J, et al. Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19. Cancer Res. 2014;74:3306-16 pubmed publisher
    ..Although it is well established that FGF19 acts through the receptor complex FGFR4-?-Klotho (KLB) to regulate bile acid metabolism, FGF19 is also implicated ..
  10. Reiche M, Bachmann A, Lossner U, Bluher M, Stumvoll M, Fasshauer M. Fibroblast growth factor 19 serum levels: relation to renal function and metabolic parameters. Horm Metab Res. 2010;42:178-81 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19) was recently introduced as a novel metabolic regulator reversing diabetes mellitus, hepatic steatosis, hyperlipidemia, and adiposity...
  11. Kir S, Beddow S, Samuel V, Miller P, Previs S, Suino Powell K, et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science. 2011;331:1621-4 pubmed publisher
    ..We show that FGF19 stimulates hepatic protein and glycogen synthesis but does not induce lipogenesis...
  12. Nicholes K, Guillet S, Tomlinson E, Hillan K, Wright B, Frantz G, et al. A mouse model of hepatocellular carcinoma: ectopic expression of fibroblast growth factor 19 in skeletal muscle of transgenic mice. Am J Pathol. 2002;160:2295-307 pubmed
    ..In contrast, we describe here the formation of liver tumors in transgenic mice overexpressing human fibroblast growth factor 19 (FGF19) in skeletal muscle...
  13. Goetz R, Beenken A, Ibrahimi O, Kalinina J, Olsen S, Eliseenkova A, et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 2007;27:3417-28 pubmed
    Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis...
  14. Suzuki M, Uehara Y, Motomura Matsuzaka K, Oki J, Koyama Y, Kimura M, et al. betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol. 2008;22:1006-14 pubmed publisher
    ..It is thus suggested that betaKlotho expression is a crucial determinant of the FGF21 specificity of the target cells upon which it acts in an endocrine fashion. ..
  15. Shin D, Osborne T. FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem. 2009;284:11110-20 pubmed publisher
  16. Desnoyers L, Pai R, Ferrando R, Hotzel K, Le T, Ross J, et al. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene. 2008;27:85-97 pubmed
    Although fibroblast growth factor 19 (FGF19) can promote liver carcinogenesis in mice its involvement in human cancer is not well characterized...
  17. Ng K, Stoll B, Chacko S, Sáenz de Pipaón M, Lauridsen C, Gray M, et al. Vitamin E in New-Generation Lipid Emulsions Protects Against Parenteral Nutrition-Associated Liver Disease in Parenteral Nutrition-Fed Preterm Pigs. JPEN J Parenter Enteral Nutr. 2016;40:656-71 pubmed publisher
    ..05) and portal plasma FGF19 higher in the ILE, OV, and PS vs IL...
  18. Gallot Y, Bohnert K, Straughn A, Xiong G, Hindi S, Kumar A. PERK regulates skeletal muscle mass and contractile function in adult mice. FASEB J. 2019;33:1946-1962 pubmed publisher
    ..of PERK also increases the activation of calpains and deregulates the gene expression of the members of the FGF19 subfamily...
  19. Lee J, Ong J, Vergnes L, de Aguiar Vallim T, Nolan J, Cantor R, et al. Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants. J Lipid Res. 2018;59:429-438 pubmed publisher
    ..This variant causes an H1721Q amino acid substitution that increases the levels of FGF19 protein secreted from cultured cells...
  20. Xiao Y, Zhou K, Lu Y, Yan W, Cai W, Wang Y. Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal failure via the alteration of FXR signaling. Exp Mol Med. 2018;50:155 pubmed publisher
    ..Correspondingly, the serum FGF19 levels decreased significantly in patients with cholestasis...
  21. Cai S, He H, Nguyen T, Mennone A, Boyer J. Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res. 2010;51:2265-74 pubmed publisher
    ..mRNA expression is greatly repressed by RA in both human hepatocytes and HepG2 cells where increased fibroblast growth factor 19 (FGF19) and small heterodimer partner (SHP) expressions were also observed, suggesting farnesoid X ..
  22. Gao Q, Wang Z, Duan M, Lin Y, Zhou X, Worthley D, et al. Cell Culture System for Analysis of Genetic Heterogeneity Within Hepatocellular Carcinomas and Response to Pharmacologic Agents. Gastroenterology. 2017;152:232-242.e4 pubmed publisher
    ..Genetic alterations that can be targeted by existing pharmacologic agents (such as those in FGF19, DDR2, PDGFRA, and TOP1) were identified in intratumor subregions from 4 HCCs and were associated with ..
  23. Hartmann P, Hochrath K, Horvath A, Chen P, Seebauer C, Llorente C, et al. Modulation of the intestinal bile acid-FXR-FGF15 axis improves alcoholic liver disease in mice. Hepatology. 2017;: pubmed publisher
    ..To link the beneficial metabolic effect to FGF15, a non-tumorigenic FGF19 variant - a human FGF15 ortholog - was overexpressed in mice using adeno-associated viruses...
  24. Krattinger R, Boström A, Lee S, Thasler W, Schioth H, Kullak Ublick G, et al. Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016;156:47-56 pubmed publisher
    ..g. SLCO1B1, SLC22A7, FGF19, CYP2E1, CYP1A2, APO family members and FOXO3...
  25. Mouzaki M, Wang A, Bandsma R, Comelli E, Arendt B, Zhang L, et al. Bile Acids and Dysbiosis in Non-Alcoholic Fatty Liver Disease. PLoS ONE. 2016;11:e0151829 pubmed publisher
    ..669, p<0.0001) and unconjugated CDCA (r = - 0.630, p<0.0001). FGF19 levels were not different between the groups (p = 0.114)...
  26. Escalona A, Muñoz R, Irribarra V, Solari S, Allende F, Francisco Miquel J. Bile acids synthesis decreases after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2016;12:763-769 pubmed publisher
    ..4±21.1, 4.9±8.2, 8.7±12.1, 13.8±12.9, and 18.8±16.8 ng/mL (P<.0001), respectively. Fibroblast growth factor 19 (FGF19) levels at baseline, 1, 3, 6, and 12 months were 71±33.3, 130.5±66.2, 117.8±57.2, 134...
  27. Kaválková P, Mraz M, Trachta P, Klouckova J, Cinkajzlova A, Lacinova Z, et al. Endocrine effects of duodenal-jejunal exclusion in obese patients with type 2 diabetes mellitus. J Endocrinol. 2016;231:11-22 pubmed publisher
    ..Serum concentrations of fibroblast growth factor 19 (FGF19) and bile acids markedly increased together with a tendency to restoration of postprandial peak ..
  28. Mertens K, Kalsbeek A, Soeters M, Eggink H. Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System. Front Neurosci. 2017;11:617 pubmed publisher
    ..Activation of intestinal FXR and TGR5 receptors can result in the release of fibroblast growth factor 19 (FGF19) and glucagon-like peptide 1 (GLP-1), both capable of signaling to the CNS...
  29. Yang C, Jin C, Li X, Wang F, McKeehan W, Luo Y. Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB. PLoS ONE. 2012;7:e33870 pubmed publisher
    Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes...
  30. Tamimi Y, Skarie J, Footz T, Berry F, Link B, Walter M. FGF19 is a target for FOXC1 regulation in ciliary body-derived cells. Hum Mol Genet. 2006;15:3229-40 pubmed
    ..nickel agarose chromatin enrichment with human anterior segment cells, we previously identified the fibroblast growth factor 19 (FGF19) locus as a gene potentially regulated by FOXC1...
  31. Vijayvargiya P, Camilleri M. Update on Bile Acid Malabsorption: Finally Ready for Prime Time?. Curr Gastroenterol Rep. 2018;20:10 pubmed publisher
    ..testing-new diagnostic tests have been launched in the USA (serum C4 and fecal 48-h BA excretion); stimulated FGF19 has higher detection of BAM compared to fasting sample alone...
  32. Miyata M, Hata T, Yamakawa H, Kagawa T, Yoshinari K, Yamazoe Y. Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19. J Steroid Biochem Mol Biol. 2012;132:41-7 pubmed publisher
    The intestinal endocrine hormone human fibroblast growth factor 19 (FGF19) is involved in the regulation of not only hepatic bile acid metabolism but also carbohydrate and lipid metabolism...
  33. Shimizu M, Li J, Maruyama R, Inoue J, Sato R. FGF19 (fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress. Biochem J. 2013;450:221-9 pubmed publisher
    FGF19 (fibroblast growth factor 19), expressed in the small intestine, acts as an enterohepatic hormone by mediating inhibitory effects on the bile acid synthetic pathway and regulating carbohydrate and lipid metabolism...
  34. Guan D, Zhao L, Chen D, Yu B, Yu J. Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state. J Transl Med. 2016;14:63 pubmed publisher
    Fibroblast growth factor (FGF) 15/19 and FGF21 are two atypical members of FGF19 subfamily that function as hormones...
  35. Zweers S, de Vries E, Lenicek M, Tolenaars D, de Waart D, Koelfat K, et al. Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge. Hepatol Int. 2017;11:132-140 pubmed publisher
    ..b>Fibroblast growth factor 19 (FGF19) is a bile salt-induced enterokine with hepatoprotective potential as it suppresses de novo bile ..
  36. Sachdev S, Wang Q, Billington C, Connett J, Ahmed L, Inabnet W, et al. FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes. Obes Surg. 2016;26:957-65 pubmed publisher
    This study aims to quantify changes in fibroblast growth factor 19 (FGF19) and bile acids (BAs) in patients with uncontrolled type 2 diabetes randomized to Roux-en-Y gastric bypass (RYGB) vs intensive medical management (IMM) and matched ..
  37. Donate Correa J, Martín Núñez E, Delgado N, de Fuentes M, Arduan A, Mora Fernández C, et al. Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes. Cytokine Growth Factor Rev. 2016;28:71-7 pubmed publisher
    ..More specifically, FGF19 and FGF21 signaling pathways have been linked to different glucose metabolic processes, including hepatic glucose ..
  38. Harrison S, Rinella M, Abdelmalek M, Trotter J, Paredes A, Arnold H, et al. NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial. Lancet. 2018;391:1174-1185 pubmed publisher
    ..b>FGF19 is a hormone that regulates bile acid synthesis and glucose homoeostasis...
  39. Barrera F, Azócar L, Molina H, Schalper K, Ocares M, Liberona J, et al. Effect of cholecystectomy on bile acid synthesis and circulating levels of fibroblast growth factor 19. Ann Hepatol. 2015;14:710-21 pubmed
    Background and rationale for the study. FGF19/15 is a gut-derived hormone presumably governing bile acid (BA) synthesis and gallbladder (GB) refilling...
  40. Upadhyay P, Gardi N, Desai S, Chandrani P, Joshi A, Dharavath B, et al. Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases. Oral Oncol. 2017;73:56-64 pubmed publisher
    ..Similarly, significant gains at genomic locus 11q13.3 (CCND1, FGF19, ORAOV1, FADD), 5p15.33 (SHANK2, MMP16, TERT), and 8q24.3 (BOP1); and, losses at 5q22.2 (APC), 6q25...
  41. Hyeon J, Ahn S, Lee J, Song D, Park C. Expression of fibroblast growth factor 19 is associated with recurrence and poor prognosis of hepatocellular carcinoma. Dig Dis Sci. 2013;58:1916-22 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19)-mediated activation of mitogen-activated protein kinase and the ?-catenin pathway may be involved in the development and progression of hepatocellular carcinoma...
  42. Martinez Ferre A, Lloret Quesada C, Prakash N, Wurst W, Rubenstein J, Martinez S. Fgf15 regulates thalamic development by controlling the expression of proneural genes. Brain Struct Funct. 2016;221:3095-109 pubmed publisher
    ..Fgf15, the mouse gene orthologous of human, chick, and zebrafish Fgf19, is induced by Shh signal and expressed in the diencephalic alar plate progenitors during histogenetic ..
  43. Zhou M, Luo J, Chen M, Yang H, Learned R, Depaoli A, et al. Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15. J Hepatol. 2017;66:1182-1192 pubmed publisher
    ..Activation of the nuclear receptor, FXR, leads to the production of a hormone called fibroblast growth factor 19 (FGF19) and subsequently regulation of multiple metabolic processes...
  44. Zweers S, Booij K, Komuta M, Roskams T, Gouma D, Jansen P, et al. The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract. Hepatology. 2012;55:575-83 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19) plays a crucial role in the negative feedback regulation of bile salt synthesis...
  45. Nishimura T, Utsunomiya Y, Hoshikawa M, Ohuchi H, Itoh N. Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain. Biochim Biophys Acta. 1999;1444:148-51 pubmed
  46. Alisi A, Ceccarelli S, Panera N, Prono F, Petrini S, De Stefanis C, et al. Association between Serum Atypical Fibroblast Growth Factors 21 and 19 and Pediatric Nonalcoholic Fatty Liver Disease. PLoS ONE. 2013;8:e67160 pubmed publisher
    ..Contradictory findings are available about the association of FGF21 and FGF19 with nonalcoholic fatty liver disease (NAFLD) in humans...
  47. van Nierop F, Kulik W, Endert E, Schaap F, Olde Damink S, Romijn J, et al. Effects of acute dietary weight loss on postprandial plasma bile acid responses in obese insulin resistant subjects. Clin Nutr. 2017;36:1615-1620 pubmed publisher
    ..We measured postprandial plasma levels of glucose, insulin, BA and the BA-induced enterokine fibroblast growth factor 19 (FGF19). The VLCD decreased weight by 4.5 ± 2.3 kg (p < 0.0001) within 14 days...
  48. Mazidi M, de Caravatto P, Speakman J, Cohen R. Mechanisms of Action of Surgical Interventions on Weight-Related Diseases: the Potential Role of Bile Acids. Obes Surg. 2017;27:826-836 pubmed publisher
    ..acids after surgery may play a major role through activation of the farnesoid X receptor A (FXRA), the fibroblast growth factor 19 (FGF19), and the G protein-coupled bile acid receptor (TGR5)...
  49. Milkiewicz M, Klak M, Kempińska Podhorodecka A, Wiechowska Kozlowska A, Urasinska E, Blatkiewicz M, et al. Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis. Sci Rep. 2016;6:39573 pubmed publisher
    ..An intestinal fibroblast growth factor (FGF19) protein expression was significantly enhanced in ascending colon...
  50. de Boer J, Schonewille M, Boesjes M, Wolters H, Bloks V, Bos T, et al. Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. Gastroenterology. 2017;152:1126-1138.e6 pubmed publisher
    ..In mice, we found TICE to be regulated by intestinal FXR via induction of its target gene Fgf15 (FGF19 in rats and human beings)...
  51. Motylewska E, Stepien T, Borkowska M, Kuzdak K, Siejka A, Komorowski J, et al. Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer. Cytokine. 2018;105:32-36 pubmed publisher
    ..as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19)...
  52. Alvarez Sola G, Uriarte I, Latasa M, Jiménez M, Barcena Varela M, Santamaría E, et al. Engineered fibroblast growth factor 19 protects from acetaminophen-induced liver injury and stimulates aged liver regeneration in mice. Cell Death Dis. 2017;8:e3083 pubmed publisher
    ..b>Fibroblast growth factor 19 (FGF19, rodent FGF15) is an enterokine that regulates liver bile acid and lipid metabolism, and ..
  53. Docherty N, le Roux C. Physiological adaptations following Roux-en-Y gastric bypass and the identification of targets for bariatric mimetic pharmacotherapy. Curr Opin Pharmacol. 2015;25:23-9 pubmed publisher
    ..These are (1) exaggerated post-prandial gut hormone responses; (2) local increases in undiluted bile in the gut lumen and augmented circulating bile acid and FGF19 concentrations and (3) compositional changes in the gut microbiota.
  54. Wang S, Zhao D, Tian R, Shi H, Chen X, Liu W, et al. FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion. Oncol Res. 2016;23:197-203 pubmed publisher
    ..Since patients are often diagnosed at a late stage, very few effective therapies are left in the arsenal. FGF19, as a hormone, has been reported to promote tumor growth in various types of cancer; however, its function in ..
  55. Ross J, Gay L, Nozad S, Wang K, Ali S, Boguniewicz A, et al. Clinically advanced and metastatic pure mucinous carcinoma of the breast: a comprehensive genomic profiling study. Breast Cancer Res Treat. 2016;155:405-13 pubmed publisher
    ..005). Other frequently altered genes of interest in pmucBC were CCND1 and the FGF3/FGF4/FGF19 amplicon (27 %), often co-amplified together...
  56. Jones S. Physiology of FGF15/19. Adv Exp Med Biol. 2012;728:171-82 pubmed publisher
    ..will review the various biological actions of the mouse fibroblast growth factor 15 (Fgf15) and human fibroblast growth factor 19 (FGF19)...
  57. Wang J, Lee C, Lee W, Lee I, Lin S, Lee W, et al. Factors associated with fibroblast growth factor 19 increment after oral glucose loading in patients who were previously admitted for coronary angiography. Clin Chim Acta. 2015;450:237-42 pubmed publisher
    We investigated factors associated with fibroblast growth factor 19 (FGF-19) increment after oral glucose loading (OGL) in human subjects...
  58. Unal H, Demiralay E, Tepeoğlu M, Fidan C, Kilickap S. Lack of relationships between FGF19 staining pattern, lymph node metastasis and locally invasive characteristics of the tumor in colorectal cancers. Asian Pac J Cancer Prev. 2013;14:3151-4 pubmed
    ..Tumor tissue samples were stained with an immunohistochemistry method for FGF 19 evaluation and the staining pattern was statistically compared with the above mentioned characteristics of the ..
  59. Borup C, Wildt S, Rumessen J, Bouchelouche P, Graff J, Damgaard M, et al. Chenodeoxycholic acid stimulated fibroblast growth factor 19 response - a potential biochemical test for bile acid diarrhoea. Aliment Pharmacol Ther. 2017;45:1433-1442 pubmed publisher
    Bile acid diarrhoea is underdiagnosed and better diagnostic tests are needed. Fasting serum fibroblast growth factor-19 (FGF19) has insufficient diagnostic value, but this may be improved by stimulation.
  60. Turnbull C, Ahmed S, Morrison J, Pernet D, Renwick A, Maranian M, et al. Genome-wide association study identifies five new breast cancer susceptibility loci. Nat Genet. 2010;42:504-7 pubmed publisher
  61. Pattni S, Brydon W, Dew T, Johnston I, Nolan J, Srinivas M, et al. Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT retention. Aliment Pharmacol Ther. 2013;38:967-76 pubmed publisher
    ..with bile acid diarrhoea have lower median levels compared with healthy controls, of the ileal hormone fibroblast growth factor 19 (FGF19), which regulates bile acid synthesis...
  62. Roesch S, Styer A, Wood G, Kosak Z, Seiler J, Benotti P, et al. Perturbations of fibroblast growth factors 19 and 21 in type 2 diabetes. PLoS ONE. 2015;10:e0116928 pubmed publisher
    Fibroblast growth factors 19 and 21 (FGF19 and FGF21) have been implicated, independently, in type 2 diabetes (T2D) but it is not known if their circulating levels correlate with each other or whether the associated hepatic signaling ..
  63. Schaap F, van der Gaag N, Gouma D, Jansen P. High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology. 2009;49:1228-35 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19) is an endocrine factor produced by the small intestine in response to uptake of luminal bile salts...
  64. Zhang J, Li H, Zhou H, Fang L, Xu J, Yan H, et al. Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose. Sci Rep. 2017;7:6042 pubmed publisher
    The gut-derived hormone Fibroblast growth factor 19 (FGF19) could regulate glucose metabolism and is induced by bile acids (BAs) through activating Farnesoid X Receptor (FXR)...
  65. You M, Zhou Z, Daniels M, Jogasuria A. Endocrine Adiponectin-FGF15/19 Axis in Ethanol-Induced Inflammation and Alcoholic Liver Injury. Gene Expr. 2017;: pubmed publisher
    ..Adiponectin is a hormone secreted from adipocytes. Fibroblast growth factor (FGF) 15 (human homolog, FGF19) is an ileum-derived hormone...
  66. Tiong K, Tan B, Choo H, Chung F, Hii L, Tan S, et al. Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival. Oncotarget. 2016;7:57633-57650 pubmed publisher
    ..Importantly, a subset of basal-like breast cancer cells also secrete fibroblast growth factor 19 (FGF19), a canonical ligand specific for FGFR4...
  67. Gao L, Shay C, Lv F, Wang X, Teng Y. Implications of FGF19 on sorafenib-mediated nitric oxide production in hepatocellular carcinoma cells - a short report. Cell Oncol (Dordr). 2018;41:85-91 pubmed publisher
    ..Previous work has shown that fibroblast growth factor 19 (FGF19), an oncogenic driver, acts as a negative regulator of the therapeutic efficacy of the tyrosine ..
  68. Zhang X, Kong M, Zhang Z, Xu S, Yan F, Wei L, et al. FGF19 genetic amplification as a potential therapeutic target in lung squamous cell carcinomas. Thorac Cancer. 2017;8:655-665 pubmed publisher
    Although FGF19 gene aberrations are associated with carcinogenesis and progression in human cancers, the roles of FGF19 genetic amplification and expression in Chinese patients with lung squamous cell carcinoma (LSCC) and FGF19 ..
  69. Hao Y, Zhou J, Zhou M, Ma X, Lu Z, Gao M, et al. Serum levels of fibroblast growth factor 19 are inversely associated with coronary artery disease in chinese individuals. PLoS ONE. 2013;8:e72345 pubmed publisher
    The fibroblast growth factor 19 (FGF19) has been implicated in recent studies as a potential regulator of glucose and lipid metabolism, which may lead to atherosclerosis...
  70. Harmer N, Pellegrini L, Chirgadze D, Fernandez Recio J, Blundell T. The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity. Biochemistry. 2004;43:629-40 pubmed
    ..b>FGF19, one of the most divergent human FGFs, is unique in binding solely to one receptor, FGFR4...
  71. Slijepcevic D, Roscam Abbing R, Katafuchi T, Blank A, Donkers J, Van Hoppe S, et al. Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice. Hepatology. 2017;66:1631-1643 pubmed publisher
    ..Effects of fibroblast growth factor 19 (FGF19) on hepatic transporter mRNA levels were assessed in rat hepatoma cells and in mice by peptide ..
  72. Arab J, Cabrera D, Arrese M. Bile Acids in Cholestasis and its Treatment. Ann Hepatol. 2017;16:47-51 pubmed publisher
    ..BA such as the conjugation-resistant nor- ursodeoxycholic acid, nuclear receptors (FXR, PPAR-alpha) agonists, FGF19 analogues, inhibitors of the apical sodium-dependent bile acid transporter [ASBT] and modulators of the ..
  73. Picard A, Soyer J, Berney X, Tarussio D, Quenneville S, Jan M, et al. A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion. Cell Rep. 2016;17:1795-1806 pubmed publisher
    ..Intracerebroventricular injection of FGF19, the human ortholog of Fgf15, reduced activation by neuroglucopenia of dorsal vagal complex neurons, of the ..
  74. Dixon P, Wadsworth C, Chambers J, Donnelly J, Cooley S, Buckley R, et al. A comprehensive analysis of common genetic variation around six candidate loci for intrahepatic cholestasis of pregnancy. Am J Gastroenterol. 2014;109:76-84 pubmed publisher
    ..around candidate loci with biological plausibility for a role in ICP (ABCB4, ABCB11, ABCC2, ATP8B1, NR1H4, and FGF19)...
  75. Hu X, Xiong Q, Xu Y, Zhang X, Pan X, Ma X, et al. Association of serum fibroblast growth factor 19 levels with visceral fat accumulation is independent of glucose tolerance status. Nutr Metab Cardiovasc Dis. 2018;28:119-125 pubmed publisher
    ..This study aimed to investigate the association of serum FGF19 levels with obesity and visceral fat accumulation in a Chinese population with differing glucose tolerance status...
  76. Tan Q, Li F, Wang G, Xia W, Li Z, Niu X, et al. Identification of FGF19 as a prognostic marker and potential driver gene of lung squamous cell carcinomas in Chinese smoking patients. Oncotarget. 2016;7:18394-402 pubmed publisher
    ..Importantly, an amplification region containing FGF19, FGF3, FGF4 and CCND1 was found five-times more frequent in S-LSCC than in NS-LSCC...
  77. Koelfat K, Bloemen J, Jansen P, Dejong C, Schaap F, Olde Damink S. The portal-drained viscera release fibroblast growth factor 19 in humans. Physiol Rep. 2016;4: pubmed publisher
    b>Fibroblast growth factor 19 (FGF19) is an ileum-derived endrocrine factor that is produced in response to transepithelial bile salt flux. FGF19 represses bile salt synthesis in the liver...
  78. Mena Bares L, Carmona Asenjo E, García Sánchez M, Moreno Ortega E, Maza Muret F, Guiote Moreno M, et al. 75SeHCAT scan in bile acid malabsorption in chronic diarrhoea. Rev Esp Med Nucl Imagen Mol. 2017;36:37-47 pubmed publisher
    ..that it's not available in all countries, so other diagnostic methods have appeared, such as serum measurement of FGF19 and C4, however they are significantly more complex and costly...
  79. Appleby R, Nolan J, Johnston I, Pattni S, Fox J, Walters J. Novel associations of bile acid diarrhoea with fatty liver disease and gallstones: a cohort retrospective analysis. BMJ Open Gastroenterol. 2017;4:e000178 pubmed publisher
    ..Previous studies have identified associations with low levels of the ileal hormone fibroblast growth factor 19 (FGF19), obesity and hypertriglyceridaemia...
  80. Sawey E, Chanrion M, Cai C, Wu G, Zhang J, Zender L, et al. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell. 2011;19:347-58 pubmed publisher
    ..3, FGF19. Although it is widely assumed that CCND1 is the main driving oncogene of this common amplicon (15% frequency ..
  81. Teng Y, Zhao H, Gao L, Zhang W, Shull A, Shay C. FGF19 Protects Hepatocellular Carcinoma Cells against Endoplasmic Reticulum Stress via Activation of FGFR4-GSK3β-Nrf2 Signaling. Cancer Res. 2017;77:6215-6225 pubmed publisher
    ..In this study, we show that the fibroblast growth factor FGF19, a gene frequently amplified in hepatocellular carcinoma (HCC), facilitates a survival response to ER stress...
  82. Buhmeida A, Dallol A, Merdad A, Al Maghrabi J, Gari M, Abu Elmagd M, et al. High fibroblast growth factor 19 (FGF19) expression predicts worse prognosis in invasive ductal carcinoma of breast. Tumour Biol. 2014;35:2817-24 pubmed publisher
    ..Aberrant expression of metabolic effectors such as fibroblast growth factor 19 (FGF19) could be therefore associated with the disease...
  83. Li Y, Zhang W, Doughtie A, Cui G, Li X, Pandit H, et al. Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma. Oncotarget. 2016;7:52329-52339 pubmed publisher
    Human fibroblast growth factor 19 (FGF19), its receptor (FGFR4) and EpCAM play an important role in cell proliferation, differentiation, motility, and overexpression have been linked to hepatocellular carcinoma (HCC)...
  84. Wang D, Zhu W, Li J, An C, Wang Z. Serum concentrations of fibroblast growth factors 19 and 21 in women with gestational diabetes mellitus: association with insulin resistance, adiponectin, and polycystic ovary syndrome history. PLoS ONE. 2013;8:e81190 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19) and FGF21 are considered to be novel adipokines that improve glucose tolerance and insulin sensitivity...
  85. Degirolamo C, Sabbà C, Moschetta A. Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov. 2016;15:51-69 pubmed publisher
    The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and ..
  86. Fang Q, Li H, Song Q, Yang W, Hou X, Ma X, et al. Serum fibroblast growth factor 19 levels are decreased in Chinese subjects with impaired fasting glucose and inversely associated with fasting plasma glucose levels. Diabetes Care. 2013;36:2810-4 pubmed publisher
    b>Fibroblast growth factor 19 (FGF19), a hormone secreted from the small intestine, has recently been shown to stimulate glycogen synthesis and inhibit gluconeogenesis through insulin-independent pathways...
  87. Nakamura M, Uehara Y, Asada M, Suzuki M, Imamura T. Sulfated glycosaminoglycan-assisted receptor specificity of human fibroblast growth factor (FGF) 19 signaling in a mouse system is different from that in a human system. J Biomol Screen. 2013;18:321-30 pubmed publisher
    The endocrine action of human (h) intestine-derived fibroblast growth factor 19 (hFGF19) toward liver cells necessitates a highly specific recognition system...
  88. Vijayvargiya P, Camilleri M, Carlson P, Lueke A, O NEILL J, Burton D, et al. Performance characteristics of serum C4 and FGF19 measurements to exclude the diagnosis of bile acid diarrhoea in IBS-diarrhoea and functional diarrhoea. Aliment Pharmacol Ther. 2017;46:581-588 pubmed publisher
    The serum biomarkers, elevated 7?C4 (C4) and decreased FGF19, have been proposed as screening tests for bile acid diarrhoea.
  89. Chennamsetty I, Claudel T, Kostner K, Trauner M, Kostner G. FGF19 signaling cascade suppresses APOA gene expression. Arterioscler Thromb Vasc Biol. 2012;32:1220-7 pubmed publisher
    ..Transgenic human APOA mice (tg-APO mice) were injected with 1 mg/kg of recombinant human fibroblast growth factor 19 (FGF19). This led to a significant reduction of plasma APOA and hepatic expression of APOA...
  90. Li Z, Lin B, Lin G, Wu Y, Jie Y, Li X, et al. Circulating FGF19 closely correlates with bile acid synthesis and cholestasis in patients with primary biliary cirrhosis. PLoS ONE. 2017;12:e0178580 pubmed publisher
    Bile acid (BA) synthesis in the liver is regulated by Fibroblast Growth Factor 19 (FGF19) secreted from the ileum as an enterohepatic feedback mechanism...
  91. Wunsch E, Milkiewicz M, Wasik U, Trottier J, Kempińska Podhorodecka A, Elias E, et al. Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease. Sci Rep. 2015;5:13462 pubmed publisher
    ..Whether fibroblast growth factor 19 (FGF19) or farnesoid X receptor (FXR) dependent signaling are involved in the regulation of BA ..