FGF13

Summary

Gene Symbol: FGF13
Description: fibroblast growth factor 13
Alias: FGF-13, FGF2, FHF-2, FHF2, fibroblast growth factor 13, fibroblast growth factor homologous factor 2
Species: human
Products:     FGF13

Top Publications

  1. Munoz Sanjuan I, Smallwood P, Nathans J. Isoform diversity among fibroblast growth factor homologous factors is generated by alternative promoter usage and differential splicing. J Biol Chem. 2000;275:2589-97 pubmed
  2. Schoorlemmer J, Goldfarb M. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. J Biol Chem. 2002;277:49111-9 pubmed
    ..Binding of p38delta to IB2 is mediated by the carboxyl-terminal half of the scaffold (IB2(Delta1-436)). FHF2 also binds weakly to IB2(Delta1-436) and can thereby increase p38delta interaction with IB2(Delta1-436)...
  3. Wittmack E, Rush A, Craner M, Goldfarb M, Waxman S, Dib Hajj S. Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of dorsal root axons. J Neurosci. 2004;24:6765-75 pubmed
    ..b>FHF2 is abundantly expressed in the hippocampus and DRG neurons and colocalizes with Na(v)1...
  4. Kameyama H, Udagawa O, Hoshi T, Toukairin Y, Arai T, Nogami M. The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds. Leg Med (Tokyo). 2015;17:255-60 pubmed publisher
    ..Interestingly, lymphgangiogenic factors FOXC2, PROX1, and FGF2 also showed the statistically significant decreases...
  5. Chadid T, Morris A, Surowiec A, Robinson S, Sasaki M, Galipeau J, et al. Reversible secretome and signaling defects in diabetic mesenchymal stem cells from peripheral arterial disease patients. J Vasc Surg. 2018;68:137S-151S.e2 pubmed publisher
    ..kinases 1 and 2 expression in dMSCs under standard culture (5% fetal bovine serum plus fibroblast growth factor 2 [FGF2]), 5% human PL, or 5% fetal bovine serum plus EGF. Healthy donor MSCs were control cells...
  6. Guan G, Li R, Tang W, Liu T, Su Z, Wang Y, et al. Expression of RNA-binding motif 10 is associated with advanced tumor stage and malignant behaviors of lung adenocarcinoma cancer cells. Tumour Biol. 2017;39:1010428317691740 pubmed publisher
    ..Expression of FGF2, EGFR, WNT5A, NF-κB, and RAP1A was downregulated, whereas expression of AKT2, BIRC3, and JUN was upregulated...
  7. Singewald N, Schmuckermair C, Whittle N, Holmes A, Ressler K. Pharmacology of cognitive enhancers for exposure-based therapy of fear, anxiety and trauma-related disorders. Pharmacol Ther. 2015;149:150-90 pubmed publisher
    ..cannabinoids, neuropeptides (oxytocin, neuropeptides Y and S, opioids) and other targets (neurotrophins BDNF and FGF2, glucocorticoids, L-type-calcium channels, epigenetic modifications) as well as their downstream signaling pathways,..
  8. Davidov T, Nagar M, Kierson M, Chekmareva M, Chen C, Lu S, et al. Carbonic anhydrase 4 and crystallin α-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. J Surg Res. 2014;190:565-74 pubmed publisher
    ..glutamic oxaloacetic transaminase 1 (GOT1), trefoil factor 3 (TFF3), Friedreich Ataxia gene (X123), fibroblast growth factor 13 (FGF13), carbonic anhydrase 4 (CA4), crystallin alpha-B (CRYAB), peptidylprolyl isomerase F (PPIF), ..
  9. Negishi T, Matsumoto M, Kojima M, Asai R, Kanehira T, Sakaguchi F, et al. Diphenylarsinic Acid Induced Activation of Cultured Rat Cerebellar Astrocytes: Phosphorylation of Mitogen-Activated Protein Kinases, Upregulation of Transcription Factors, and Release of Brain-Active Cytokines. Toxicol Sci. 2016;150:74-83 pubmed publisher
    ..proteins (heme oxygenase-1 and heat shock protein 70), and induced the release of cytokines (MCP-1, adrenomedullin, FGF2, CXCL1, and IL-6)...

More Information

Publications145 found, 100 shown here

  1. Mitton K, Guzman A, Deshpande M, Byrd D, DeLooff C, Mkoyan K, et al. Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. Mol Vis. 2014;20:1527-44 pubmed
    ..The expression of Bdnf, Gdnf, Cntf, and Fgf2 was measured by quantitative PCR after single and multiple doses of VPA (intraperitoneal) in wild-type and Pde6b(..
  2. Mykhaylichenko V, Kubyshkin A, Samarin S, Fomochkina I, Anisimova L. Experimental induction of reparative morphogenesis and adaptive reserves in the ischemic myocardium using multipotent mesenchymal bone marrow-derived stem cells. Pathophysiology. 2016;23:95-104 pubmed publisher
    ..levels of nitric oxide, endothelin-1, vascular endothelial growth factor (VEGF), and fibroblast growth factor 2 (FGF2)...
  3. Tassi E, Lai E, Li L, Solis G, Chen Y, Kietzman W, et al. Blood Pressure Control by a Secreted FGFBP1 (Fibroblast Growth Factor-Binding Protein). Hypertension. 2018;71:160-167 pubmed publisher
    ..Furthermore, AngII-mediated constriction of renal afferent arterioles is abolished in FGF2-/- mice but can be restored by add-back of FGF2 plus BP1 proteins...
  4. Sato S, Shinohara S, Hayashi S, Morizumi S, Abe S, Okazaki H, et al. Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity. Respir Res. 2017;18:172 pubmed publisher
    ..Human fibrocytes produced PDGF, FGF2, and VEGF-A...
  5. Osadnik T, Strzelczyk J, Lekston A, Reguła R, Bujak K, Fronczek M, et al. The association of functional polymorphisms in genes encoding growth factors for endothelial cells and smooth muscle cells with the severity of coronary artery disease. BMC Cardiovasc Disord. 2016;16:218 pubmed
    ..analyze the relationships between functional polymorphisms in genes encoding basic fibroblast growth factor (bFGF, FGF2), epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), platelet derived growth factor-B (PDGFB), ..
  6. Xiao L, Esliger A, Hurley M. Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro. J Bone Miner Res. 2013;28:35-45 pubmed publisher
    ..Our results suggest that phosphate-independent effects of HMW isoforms in vitro may be directly mediated in part via FGF23 and that HMW isoforms signal via FGF23/FGFR/MAPK to inhibit bone formation in vitro. ..
  7. Tobias I, Brooks C, Teichroeb J, Villagómez D, Hess D, Séguin C, et al. Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naïve Pluripotency. Stem Cells Dev. 2016;25:1208-22 pubmed publisher
    ..Herein, we converted leukemia inhibitory factor (LIF)-dependent and fibroblast growth factor 2 (FGF2)-dependent canine embryonic stem cells (cESCs) resembling primed PSCs toward a naïve pluripotent state using LIF ..
  8. Irwin L, Byers D. Novel odors affect gene expression for cytokines and proteinases in the rat amygdala and hippocampus. Brain Res. 2012;1489:1-7 pubmed publisher
    ..amygdala significant up-regulation of interleukin-1 receptor 1 (IL1r1), interleukin-4 receptor (IL4r), fibroblast growth factor 13 (FGF13), and cathepsin-H (CtsH) was observed in males in response to the odor of cornnuts only...
  9. Khan S, Villalobos M, Choron R, Chang S, Brown S, Carpenter J, et al. Fibroblast growth factor and vascular endothelial growth factor play a critical role in endotheliogenesis from human adipose-derived stem cells. J Vasc Surg. 2017;65:1483-1492 pubmed publisher
    ..Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF) play a major role in angiogenesis and wound healing...
  10. Kim J, Kim S, Han I, Sim S, Ahn M, Ryu J. Proliferation of Prostate Stromal Cell Induced by Benign Prostatic Hyperplasia Epithelial Cell Stimulated With Trichomonas vaginalis via Crosstalk With Mast Cell. Prostate. 2016;76:1431-44 pubmed publisher
    ..Moreover, the expression of FGF2, cyclin D1, and Bcl-2 was increased in the proliferated stromal cells stimulated with M-TCM...
  11. Minhas G, Prabhakar S, Morishita R, Shimamura M, Bansal R, Anand A. Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia-reperfusion injury in mice. Mol Cell Biochem. 2017;429:123-136 pubmed publisher
    ..The neurotrophic factors such as BDNF and FGF2 showed enhanced expression in the retina...
  12. Gurung S, Deane J, Darzi S, Werkmeister J, Gargett C. In Vivo Survival of Human Endometrial Mesenchymal Stem Cells Transplanted Under the Kidney Capsule of Immunocompromised Mice. Stem Cells Dev. 2018;27:35-43 pubmed publisher
    ..cell sorting and cultured until passage 6 in 5% O2 in serum-free medium with fibroblast growth factor 2 (FGF2) and epidermal growth factor (EGF)...
  13. Wang Z, Wang Y, Yang T, Li J, Yang X. Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice. Stem Cell Res Ther. 2017;8:11 pubmed publisher
    ..MenSCs and CM derived from these cells exerted protective effects on damaged ovaries partially by secreting FGF2. MenSCs repair ovarian injury, improve ovarian function, and stimulate regeneration, suggesting that ..
  14. Quinn K, Prosser S, Kane K, Ashley R. Inhibition of chemokine (C-X-C motif) receptor four (CXCR4) at the fetal-maternal interface during early gestation in sheep: alterations in expression of chemokines, angiogenic factors and their receptors. J Anim Sci. 2017;95:1144-11153 pubmed publisher
    ..VEGF), kinase insert domain receptor (KDR), fms related tyrosine kinase 1 (FLT1), fibroblast growth factor 2 (FGF2), angiopoietin 1 (ANGPT1), hypoxia inducible factor 1 ? subunit (HIF1A), CXCL12, and its corresponding receptors (..
  15. de Assuncao T, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto D, et al. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J Biol Chem. 2014;289:15798-809 pubmed publisher
    ..In this study, we identified SK1 as a target of the canonical FGF2/FGF receptor 1 activation pathway in endothelial cells and sought to identify novel transcriptional pathways that ..
  16. Berger C, Boggavarapu N, Menezes J, Lalitkumar P, Gemzell Danielsson K. Effects of ulipristal acetate on human embryo attachment and endometrial cell gene expression in an in vitro co-culture system. Hum Reprod. 2015;30:800-11 pubmed publisher
    ..025) had a significant up-regulation and 4 genes, namely HAND2 (P = 0.003), OPN (P = 0.003), CALCR (P = 0.016) and FGF2 (P = 0.023) were down-regulated with the exposure of UPA, compared with control group...
  17. Kawanishi Y, Nakasa T, Shoji T, Hamanishi M, Shimizu R, Kamei N, et al. Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model. Arthritis Res Ther. 2014;16:488 pubmed publisher
    ..Collagen type 2 alpha 1 (Col2a1), Vascular endothelial growth factor (VEGF), and Fibroblast growth factor-2 (FGF2) in the miR-210 group was significantly higher than that in the control...
  18. Lim W, Bae H, Bazer F, Song G. Stimulatory effects of fibroblast growth factor 2 on proliferation and migration of uterine luminal epithelial cells during early pregnancy. Biol Reprod. 2017;96:185-198 pubmed publisher
    Fibroblast growth factor 2 (FGF2) is a mitogen that induces proliferation, differentiation, and migration of cells, as well as angiogenesis and carcinogenesis via autocrine or paracrine actions...
  19. Zhang X, Li S, Li M, Huang H, Li J, Zhou C. Hypoxia-inducible factor-1? mediates the toll-like receptor 4 signaling pathway leading to anti-tumor effects in human hepatocellular carcinoma cells under hypoxic conditions. Oncol Lett. 2016;12:1034-1040 pubmed
    ..EGF), hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2), were examined using quantitative polymerase chain reaction and immunoblotting...
  20. Tawiah A, Moreau F, Kumar M, Tiwari S, Falguera J, Chadee K. High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors. Am J Pathol. 2018;188:2025-2041 pubmed publisher
    ..wounds faster than HT29-H cells by producing significantly higher amounts of fibroblast growth factor (FGF) 1, FGF2, vascular endothelial growth factor-C, and matrix metallopeptidase 1...
  21. Homer Bouthiette C, Doetschman T, Xiao L, Hurley M. Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis. J Biol Chem. 2014;289:36303-14 pubmed publisher
    We previously reported that targeted overexpression of the fibroblast growth factor 2 (FGF2) high molecular weight (HMW) isoforms in osteoblastic lineage cells in mice resulted in phenotypic changes, including dwarfism, rickets, ..
  22. Le Blanc S, Simann M, Jakob F, Schütze N, Schilling T. Fibroblast growth factors 1 and 2 inhibit adipogenesis of human bone marrow stromal cells in 3D collagen gels. Exp Cell Res. 2015;338:136-48 pubmed publisher
    ..Fibroblast growth factors 1 (FGF1) and 2 (FGF2) play important roles in several cellular processes including differentiation...
  23. Nasrabadi D, Rezaeiani S, Eslaminejad M, Shabani A. Improved Protocol for Chondrogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells -Effect of PTHrP and FGF-2 on TGFβ1/BMP2-Induced Chondrocytes Hypertrophy. Stem Cell Rev. 2018;14:755-766 pubmed publisher
    ..bone morphogenetic protein 2 (BMP2), parathyroid hormone related protein (PTHrP), and fibroblast growth factor 2 (FGF2) according to a defined program...
  24. Muscatello L, Benazzi C, Dittmer K, Thompson K, Murgiano L, Drögemüller C, et al. Ellis-van Creveld Syndrome in Grey Alpine Cattle: Morphologic, Immunophenotypic, and Molecular Characterization. Vet Pathol. 2015;52:957-66 pubmed publisher
    ..b>FGF2 was expressed in chondrocytes of all growth plate zones in the control calves but was lost in most EvC cases...
  25. Wang X, Zhang Y, Zhou L, Wei R, Dong L. Comparison of fibrin glue and Vicryl sutures in conjunctival autografting for pterygium surgery. Mol Vis. 2017;23:275-285 pubmed
    ..reports, five inflammatory cytokines, including hepatocyte growth factor (HGF), fibroblast growth factor 2 (FGF2), transforming growth factor-β1 (TGF-β1), matrix metalloproteinase 2 (MMP2), and tumor necrosis factor-α (..
  26. Ono K, Karolak M, Ndong J, Wang W, Yang X, Elefteriou F. The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation. Hum Mol Genet. 2013;22:3048-62 pubmed publisher
    ..Using wildtype (WT) and Nf1(-/-) chondrocyte cultures in vitro, we show that FGF2 pulse-stimulation triggers rapid ERK1/2 phosphorylation in both genotypes, but that return to the basal level is ..
  27. Schmitt L, Amann P, Marquardt Y, Heise R, Czaja K, Gerber P, et al. Molecular effects of fractional ablative erbium:YAG laser treatment with multiple stacked pulses on standardized human three-dimensional organotypic skin models. Lasers Med Sci. 2017;32:805-814 pubmed publisher
    ..and resulted in an upregulation of genes, such as collagen-1A2, collagen-5A2, and collagen-6A2, as well as FGF2. Histologically, all treatment settings resulted in a complete regeneration of the epidermis 3 days after ..
  28. Swartz E, Baek J, Pribadi M, Wojta K, Almeida S, Karydas A, et al. A Novel Protocol for Directed Differentiation of C9orf72-Associated Human Induced Pluripotent Stem Cells Into Contractile Skeletal Myotubes. Stem Cells Transl Med. 2016;5:1461-1472 pubmed publisher
    ..synthase kinase 3β (GSK3β) with addition of bone morphogenic protein 4 (BMP4) and fibroblast growth factor 2 (FGF2), we report up to 64% conversion of iPSCs into the myogenic program by day 36 as indicated by MYOG+ cell ..
  29. Chang Y, Tseng C, Tannenberg P, Eriksson L, Yuan K, de Jesus Perez V, et al. Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension. Cardiovasc Res. 2015;107:20-31 pubmed publisher
    ..It binds growth factors, including FGF2, and either restricts or promotes cell proliferation...
  30. Zhou C, Zou Q, Li H, Wang R, Liu A, Magness R, et al. Preeclampsia Downregulates MicroRNAs in Fetal Endothelial Cells: Roles of miR-29a/c-3p in Endothelial Function. J Clin Endocrinol Metab. 2017;102:3470-3479 pubmed publisher
    ..endothelial cells and disturbs the vascular endothelial growth factor A (VEGFA)- and fibroblast growth factor 2 (FGF2)-induced endothelial function...
  31. Park J, Kim H, Uh K, Choi K, Kim H, Lee T, et al. Primed pluripotent cell lines derived from various embryonic origins and somatic cells in pig. PLoS ONE. 2013;8:e52481 pubmed publisher
    ..Our results show that these cell lines demonstrate the expression of genes associated with the Activin/Nodal and FGF2 pathways along with the expression of pluripotent markers Oct4, Sox2, Nanog, SSEA4, TRA 1-60 and TRA 1-81...
  32. Kwon M, Proost N, Song J, Sutherland K, Zevenhoven J, Berns A. Paracrine signaling between tumor subclones of mouse SCLC: a critical role of ETS transcription factor Pea3 in facilitating metastasis. Genes Dev. 2015;29:1587-92 pubmed publisher
    ..We further show evidence that paracrine signaling via fibroblast growth factor 2 (Fgf2) and Mapk between these diverged tumor subclones causes enhanced expression of the Pea3 (polyomavirus enhancer ..
  33. Baum P, Vogt M, Gass P, Unsicker K, Von Bohlen Und Halbach O. FGF-2 deficiency causes dysregulation of Arhgef6 and downstream targets in the cerebral cortex accompanied by altered neurite outgrowth and dendritic spine morphology. Int J Dev Neurosci. 2016;50:55-64 pubmed publisher
    ..Since Arhgef6 is localized to dendritic spines, we next analyzed dendritic spines of adult FGF2(-/-) and control mouse cortices...
  34. Osteil P, Moulin A, Santamaria C, Joly T, Jouneau L, Aubry M, et al. A Panel of Embryonic Stem Cell Lines Reveals the Variety and Dynamic of Pluripotent States in Rabbits. Stem Cell Reports. 2016;7:383-398 pubmed publisher
    ..On single-cell dissociation and culture in fibroblast growth factor 2 (FGF2)-free, serum-supplemented medium, rabbit ICMs gave rise to ESC lines lacking the DNA-damage checkpoint in the G1 ..
  35. Mishra S, Thakur N, Somal A, Parmar M, Reshma R, Rajesh G, et al. Expression and localization of fibroblast growth factor (FGF) family in buffalo ovarian follicle during different stages of development and modulatory role of FGF2 on steroidogenesis and survival of cultured buffalo granulosa cells. Res Vet Sci. 2016;108:98-111 pubmed publisher
    ..the expression and localization of FGF and its functional receptors in the follicle of buffalo and the treatment of FGF2 on mRNA expression of CYP19A1 (aromatase), PCNA, and BAX (BCL-2 associated X protein) in cultured buffalo granulosa ..
  36. İlgen U, Yayla M, Duzgun N. Low serum fibroblast growth factor 2 levels not accompanied by increased serum pentraxin 3 levels in patients with systemic sclerosis. Clin Rheumatol. 2017;36:367-372 pubmed publisher
    There are scarce clinical data regarding serum pentraxin 3 (PTX3) and fibroblast growth factor 2 (FGF2) in patients with systemic sclerosis (SSc). Study was conducted to evaluate serum levels in our SSc cohort...
  37. Tourville T, Poynter M, Desarno M, Struglics A, Beynnon B. Relationship between synovial fluid ARGS-aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross-sectional study. J Orthop Res. 2015;33:1796-803 pubmed publisher
    ..Statistically significant relationships were found between ARGS and basic fibroblast growth factor (FGF2) (p=0.03) and TIMP-3 (p=0.01)...
  38. Yabe S, Alexenko A, Amita M, Yang Y, Schust D, Sadovsky Y, et al. Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas. Proc Natl Acad Sci U S A. 2016;113:E2598-607 pubmed publisher
    ..exposure to bone morphogenetic protein-4 (BMP-4) and two small compounds, an activin A signaling inhibitor and a FGF2 signaling inhibitor (BMP4/A83-01/PD173074; BAP treatment)...
  39. Zhu H, Bai W, Liu J, Zheng Z, Guan H, Zhou Q, et al. Up-regulation of FGFBP1 signaling contributes to miR-146a-induced angiogenesis in human umbilical vein endothelial cells. Sci Rep. 2016;6:25272 pubmed publisher
    ..miR-146a over expression resulted in up-regulation of angiogenesis and cytokine activity associated genes including FGF2. Further a combination of bioinformatics and experimental analyses demonstrated the CREB3L1 as a bona fide ..
  40. Thimraj T, Birru R, Mitra A, Schulz H, Leikauf G, Ganguly K. Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular. Lung. 2017;195:263-270 pubmed publisher
    ..WNT signaling target, lymphoid enhancer binding factor 1 (Lef1), also increased along with its downstream targets Fgf2, Fgf7, and Fgf10 in the lungs of Sod3-/- mice...
  41. Steringer J, Nickel W. A direct gateway into the extracellular space: Unconventional secretion of FGF2 through self-sustained plasma membrane pores. Semin Cell Dev Biol. 2018;83:3-7 pubmed publisher
    ..Here we focus on the type I pathway with Fibroblast Growth Factor 2 (FGF2) being the most prominent example...
  42. Chan W, Howe K, Clegg J, Guimond S, Price D, Turnbull J, et al. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PLoS ONE. 2015;10:e0130147 pubmed publisher
    ..In the developing mouse telencephalon Fgf2 signaling regulates proliferation and neurogenesis...
  43. Choi J, Yoon H, Lee K, Choi Y, Yang S, Kim I, et al. Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration. J Control Release. 2016;222:107-15 pubmed publisher
    ..such as insulin-like growth factors (IGFs), hepatocyte growth factor (HGF), fibroblast growth factor-2 (FGF2), and platelet-derived growth factor-AA (PDGF-AA)...
  44. Shigetani Y, Wakamatsu Y, Tachibana T, Okabe M. Conversion of neural plate explants to pre-placodal ectoderm-like tissue in vitro. Biochem Biophys Res Commun. 2016;477:807-813 pubmed publisher
    ..We therefore examined the effect of FGF2 along with BMP4 on the rostral neural plate explants and found that the explants became the simple squamous ..
  45. Li S, Hwu Y, Lu C, Chang H, Hsieh C, Lee R. VEGF and FGF2 Improve Revascularization, Survival, and Oocyte Quality of Cryopreserved, Subcutaneously-Transplanted Mouse Ovarian Tissues. Int J Mol Sci. 2016;17: pubmed publisher
    ..to investigate the effect of the vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) on revascularization, survival, and oocyte quality of cryopreserved, subcutaneously-transplanted mouse ovarian ..
  46. Park S, Arrell D, Reyes S, Park E, Terzic A. Conventional and unconventional secretory proteins expressed with silkworm bombyxin signal peptide display functional fidelity. Sci Rep. 2017;7:14499 pubmed publisher
    ..Human fibroblast growth factor 2 (FGF2) and insulin-like growth factor 1 (IGF1), are canonical prototypes secreted by the unconventional and conventional ..
  47. Fűri I, Kalmár A, Wichmann B, Spisák S, Schöller A, Barták B, et al. Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line. PLoS ONE. 2015;10:e0131699 pubmed publisher
    ..g. MYD88, IRAK2, NFκB, IL8, IL-1β), STING pathway (ADAR, IRF7, CXCL10, CASP1) and the FGF2 gene...
  48. Hurley M, Adams D, Wang L, Jiang X, Burt P, Du E, et al. Accelerated fracture healing in transgenic mice overexpressing an anabolic isoform of fibroblast growth factor 2. J Cell Biochem. 2016;117:599-611 pubmed publisher
    The effect of targeted expression of an anabolic isoform of basic fibroblast growth factor (FGF2) in osteoblastic lineage on tibial fracture healing was assessed in mice. Closed fracture of the tibiae was performed in Col3...
  49. La Venuta G, Zeitler M, Steringer J, Müller H, Nickel W. The Startling Properties of Fibroblast Growth Factor 2: How to Exit Mammalian Cells without a Signal Peptide at Hand. J Biol Chem. 2015;290:27015-20 pubmed publisher
    ..Here, we focus on unconventional secretion of fibroblast growth factor 2 (FGF2), a secretory mechanism that is based upon direct protein translocation across plasma membranes...
  50. Spiller K, Wrona E, Romero Torres S, Pallotta I, Graney P, Witherel C, et al. Differential gene expression in human, murine, and cell line-derived macrophages upon polarization. Exp Cell Res. 2016;347:1-13 pubmed publisher
    ..to commonly used phenotype markers like CCR7 and genes associated with angiogenesis and tissue regeneration like FGF2 and MMP9...
  51. Ozkaya H, Comunoglu N, Keskin F, Oz B, Haliloglu O, Tanriover N, et al. Locally produced estrogen through aromatization might enhance tissue expression of pituitary tumor transforming gene and fibroblast growth factor 2 in growth hormone-secreting adenomas. Endocrine. 2016;52:632-40 pubmed publisher
    ..estrogen receptor β (ERβ), pituitary tumor transforming gene (PTTG), and fibroblast growth factor 2 (FGF2) expressions in GH-secreting adenomas, and investigate their correlation with clinical, pathologic, and radiologic ..
  52. Bečić T, Kero D, Vukojevic K, Mardešić S, Saraga Babic M. Growth factors FGF8 and FGF2 and their receptor FGFR1, transcriptional factors Msx-1 and MSX-2, and apoptotic factors p19 and RIP5 participate in the early human limb development. Acta Histochem. 2018;120:205-214 pubmed publisher
    The expression pattern of fibroblast growth factors FGF8 and FGF2 and their receptor FGFR1, transcription factors MSX-1 and MSX-2, as well as cell proliferation (Ki-67) and cell death associated caspase-3, p19 and RIP5 factors were ..
  53. Ling L, Tan S, Goh T, Cheung E, Nurcombe V, Van Wijnen A, et al. Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy. Mol Cancer. 2015;14:136 pubmed publisher
    ..Furthermore, IMB-R1 blocks the interaction of FGF2 with FGFR1, the kinase activity of FGFR1 and activation of intracellular FGFR signaling...
  54. Lüttgenau J, Möller B, Kradolfer D, Wellnitz O, Bruckmaier R, Miyamoto A, et al. Lipopolysaccharide enhances apoptosis of corpus luteum in isolated perfused bovine ovaries in vitro. Reproduction. 2016;151:17-28 pubmed publisher
    ..receptors for LPS (TLR2, -4) and LH (LHCGR); the cytokine TNFA; steroidogenic (STAR, HSD3B), angiogenic (VEGFA121, FGF2), and vasoactive (EDN1) factors; and factors of prostaglandin synthesis (PGES, PGFS, PTGFR) and apoptosis (CASP3, -..
  55. Ueno N, Shimizu A, Kanai M, Iwaya Y, Ueda S, Nakayama J, et al. Enhanced Expression of Fibroblast Growth Factor Receptor 3 IIIc Promotes Human Esophageal Carcinoma Cell Proliferation. J Histochem Cytochem. 2016;64:7-17 pubmed publisher
    ..EC-GI-10 cells and ESCC from patients with EC showed endogenous expression of FGF2, a specific ligand for FGFR3IIIc, suggesting that the upregulated expression of FGFR3IIIc may create autocrine FGF ..
  56. Litvin Y, Turner C, Ríos M, Maras P, Chaudhury S, Baker M, et al. Fibroblast growth factor 2 alters the oxytocin receptor in a developmental model of anxiety-like behavior in male rat pups. Horm Behav. 2016;86:64-70 pubmed publisher
    ..known to regulate social and anxiety-like behaviors throughout life: oxytocin (OT) and fibroblast growth factor 2 (FGF2)...
  57. Kikuchi S, Chen L, Xiong K, Saito Y, Azuma N, Tang G, et al. Smooth muscle cells of human veins show an increased response to injury at valve sites. J Vasc Surg. 2018;67:1556-1570.e9 pubmed publisher
    ..8-fold of control, respectively; P < .001; n = 7 pairs of cells). Blockade of fibroblast growth factor 2 (FGF2) inhibited the increased responses of valve SMCs but had no effect on nonvalve SMCs...
  58. Yang J, Zhang D, Yu Y, Zhang R, Hu X, Huang H, et al. Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway. Cell Cycle. 2015;14:3318-30 pubmed publisher
    Fibroblast growth factors (FGF1, FGF2 and FGF4) and fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3 and FGFR4) have been reported to be expressed in preimplantation embryos and be required for their development...
  59. Ji Q, Xu X, Xu Y, Fan Z, Kang L, Li L, et al. miR-105/Runx2 axis mediates FGF2-induced ADAMTS expression in osteoarthritis cartilage. J Mol Med (Berl). 2016;94:681-94 pubmed publisher
    Fibroblast growth factor 2 (FGF2) plays an important role in the development of osteoarthritis (OA) through the regulation of cartilage degradation. However, the molecular mechanism underlying FGF2-induced OA is poorly characterized...
  60. Becquart P, Cruel M, Hoc T, Sudre L, Pernelle K, Bizios R, et al. Human mesenchymal stem cell responses to hydrostatic pressure and shear stress. Eur Cell Mater. 2016;31:160-73 pubmed
    ..The present study is the first to report that PGTS2, IER3, EGR1, IGF1, IGFBP1, ITGB1, VEGFA and FGF2 are involved in the response of hMSCs to ISS...
  61. Li X, Wang Z, Jiang Z, Guo J, Zhang Y, Li C, et al. Regulation of seminiferous tubule-associated stem Leydig cells in adult rat testes. Proc Natl Acad Sci U S A. 2016;113:2666-71 pubmed publisher
    ..Leydig cells was stimulated by paracrine factors including Desert hedgehog (DHH), basic fibroblast growth factor (FGF2), platelet-derived growth factor (PDGF), and activin...
  62. Traer E, Martinez J, Javidi Sharifi N, Agarwal A, Dunlap J, English I, et al. FGF2 from Marrow Microenvironment Promotes Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia. Cancer Res. 2016;76:6471-6482 pubmed publisher
    ..model of resistance whereby extrinsic microenvironmental proteins FLT3 ligand (FL) and fibroblast growth factor 2 (FGF2) protect FLT3-ITD+ MOLM14 cells from AC220, providing time for subsequent accumulation of ligand-independent ..
  63. Sadakata T, Shinoda Y, Ishizaki Y, Furuichi T. Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways. Neurosci Lett. 2017;639:88-93 pubmed publisher
    ..The expression levels of exocytosis-related genes (Stx5a, Syt6), genes encoding secretory (Fgf2, Fgf4, Edn2) and synaptic proteins (Grin2b, Gabbr1), neurotrophin signaling-associated genes (Sos1, Shc1, Traf6, ..
  64. Krishnapati L, Ghaskadbi S. Insulin induces the expression of FGF2 but does not synergize with it during angiogenesis. Microvasc Res. 2016;103:55-63 pubmed publisher
    ..Absence of combinatorial effect between insulin, FGF-2 and VEGF during angiogenesis was also demonstrated using CAM assay. ..
  65. Kingma S, Wagemans T, IJlst L, Bronckers A, van Kuppevelt T, Everts V, et al. Altered interaction and distribution of glycosaminoglycans and growth factors in mucopolysaccharidosis type I bone disease. Bone. 2016;88:92-100 pubmed publisher
    ..In this study, binding between GAGs from MPS I chondrocytes and fibroblast growth factor 2 (FGF2) was not significantly different from binding of FGF2 to GAGs from control chondrocytes...
  66. Prieto Vila M, Yan T, Calle A, Nair N, Hurley L, Kasai T, et al. iPSC-derived cancer stem cells provide a model of tumor vasculature. Am J Cancer Res. 2016;6:1906-1921 pubmed
    ..The angiogenic factors such as VEGF-A and FGF2 were expressed predominantly in the cancer stem cells subpopulation of miPS-LLCcm cells...
  67. Burel S, Coyan F, Lorenzini M, Meyer M, Lichti C, BROWN J, et al. C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation. J Biol Chem. 2017;292:17431-17448 pubmed publisher
    ..We then tested the hypothesis that phosphorylation at these two sites impairs fibroblast growth factor 13 (FGF13)-dependent regulation of NaV1.5 channel inactivation...
  68. Chen J, Cui L, Yuan J, Zhang Y, Sang H. Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124. Biochem Biophys Res Commun. 2017;494:126-132 pubmed publisher
    ..validation experiments revealed that circWDR77 regulated VSMCs proliferation and migration via targeting miR-124/FGF2. Taken together, present study firstly reveals the circRNAs expression profiles in high glucose induced VSMCs and ..
  69. Eigner K, Filik Y, Mark F, Schütz B, Klambauer G, Moriggl R, et al. The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone. Sci Rep. 2017;7:17498 pubmed publisher
    ..Using whole-genome expression analysis, we show that the UPR is an inducer of FGF1 and FGF2 expression and cell migration...
  70. Echeverri Ruiz N, Haynes T, Landers J, Woods J, Gemma M, Hughes M, et al. A biochemical basis for induction of retina regeneration by antioxidants. Dev Biol. 2018;433:394-403 pubmed publisher
    ..stem/progenitor cells present in the ciliary margin (CM) of the eye only if a source of exogenous factors, such as FGF2, is present...
  71. Okada T, Murata K, Hirose R, Matsuda C, Komatsu T, Ikekita M, et al. Upregulated expression of FGF13/FHF2 mediates resistance to platinum drugs in cervical cancer cells. Sci Rep. 2013;3:2899 pubmed publisher
    Cancer cells often develop drug resistance. In cisplatin-resistant HeLa cisR cells, fibroblast growth factor 13 (FGF13/FHF2) gene and protein expression was strongly upregulated, and intracellular platinum concentrations were kept low...
  72. Xie Q, McGreal R, Harris R, Gao C, Liu W, Reneker L, et al. Regulation of c-Maf and αA-Crystallin in Ocular Lens by Fibroblast Growth Factor Signaling. J Biol Chem. 2016;291:3947-58 pubmed publisher
    ..expression of αA-crystallin (Cryaa) through binding to its promoter and distal enhancer, DCR1, both activated by FGF2 in cell culture...
  73. Burnsed O, Schwartz Z, Marchand K, Hyzy S, Olivares Navarrete R, Boyan B. Hydrogels derived from cartilage matrices promote induction of human mesenchymal stem cell chondrogenic differentiation. Acta Biomater. 2016;43:139-149 pubmed publisher
    ..ECM had increased expression of chondrocyte markers and decreased secretion of angiogenic factors VEGF-A and FGF2 in comparison to MSCs cultured on tissue culture polystyrene (TCPS) at one week...
  74. Strunz C, Roggério A, Cruz P, Pacanaro A, Salemi V, Benvenuti L, et al. Down-regulation of fibroblast growth factor 2 and its co-receptors heparan sulfate proteoglycans by resveratrol underlies the improvement of cardiac dysfunction in experimental diabetes. J Nutr Biochem. 2017;40:219-227 pubmed publisher
    Cardiac remodeling in diabetes involves cardiac hypertrophy and fibrosis, and fibroblast growth factor 2 (FGF2) is an important mediator of this process...
  75. Mishra S, Bharati J, Rajesh G, Chauhan V, Taru Sharma G, Bag S, et al. Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA) synergistically promote steroidogenesis and survival of cultured buffalo granulosa cells. Anim Reprod Sci. 2017;179:88-97 pubmed publisher
    The present study investigated the combined effect of fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGF-A) on estradiol (E2) secretion and relative abundance of mRNA for aromatase enzyme (CYP19A1),..
  76. Marei H, El Gamal A, Althani A, Afifi N, Abd Elmaksoud A, Farag A, et al. Cholinergic and dopaminergic neuronal differentiation of human adipose tissue derived mesenchymal stem cells. J Cell Physiol. 2018;233:936-945 pubmed publisher
    ..induction of MSCs in vitro by growth factors including epidermal growth factor (EGF) and fibroblast growth factor (FGF2) causes them to differentiate into neural like cells...
  77. Wang F, Yang L, Sun J, Zheng J, Shi L, Zhang G, et al. Tumor suppressors microRNA-302d and microRNA-16 inhibit human glioblastoma multiforme by targeting NF-κB and FGF2. Mol Biosyst. 2017;13:1345-1354 pubmed publisher
    ..MiR-302d and miR-16 inhibited the expressions of p65 and FGF2, respectively, by binding to the 3'-UTR of their mRNAs...
  78. Ren G, Lutz I, Railton P, Wiley J, McAllister J, Powell J, et al. Serum and synovial fluid cytokine profiling in hip osteoarthritis: distinct from knee osteoarthritis and correlated with pain. BMC Musculoskelet Disord. 2018;19:39 pubmed publisher
    ..The three cohorts showed distinct serum cytokine profiles. EGF, FGF2, MCP3, MIP1?, and IL8 were differentially expressed between hip and knee OA cohorts; while FGF2, GRO, IL8, MCP1, ..
  79. Abu Amero K, Kondkar A, Alorainy I, Khan A, Al Enazy L, Oystreck D, et al. Xq26.3 microdeletion in a male with Wildervanck Syndrome. Ophthalmic Genet. 2014;35:18-24 pubmed publisher
    ..This deletion encompassed only one gene, Fibroblast Growth Factor Homologous Factor 13 (FGF13), which encodes a 216-amino acid protein that acts intracellularly in neurons throughout brain development...
  80. Yu L, Toriseva M, Tuomala M, Seikkula H, Elo T, Tuomela J, et al. Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy. Int J Cancer. 2016;139:140-52 pubmed publisher
    ..Mining of public database suggests that FGF13 (FHF2) mRNA expression is altered in over 30% of PCa cases...
  81. Nishino J, Yamazaki M, Kawai M, Tachikawa K, Yamamoto K, Miyagawa K, et al. Extracellular Phosphate Induces the Expression of Dentin Matrix Protein 1 Through the FGF Receptor in Osteoblasts. J Cell Biochem. 2017;118:1151-1163 pubmed publisher
    ..Pi induced the phosphorylation of ERK1/2 and up-regulated the expression of Dmp1, fibroblast growth factor 2 (Fgf2), and Fgf receptor 1 (Fgfr1)...
  82. Nakachi I, Helfrich B, Spillman M, Mickler E, Olson C, Rice J, et al. PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines. Clin Transl Sci. 2016;9:293-301 pubmed publisher
    ..In sensitive cell lines, saracatinib treatment decreased PTTG1 and fibroblast growth factor 2 (FGF2) protein levels. Downregulating PTTG1 by siRNAs increased saracatinib sensitivity in two resistant cell lines...
  83. Parmar M, Mishra S, Somal A, Pandey S, Kumar G, Sarkar M, et al. Expression and secretory profile of buffalo fetal fibroblasts and Wharton's jelly feeder layers. Anim Reprod Sci. 2017;180:66-77 pubmed publisher
    ..Signaling molecules viz. bone morphogenetic protein 4 (BMP4), fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF) and transforming growth factor beta 1 (TGFB1) and pluripotency-associated ..
  84. Royall L, Lea D, Matsushita T, Takeda T, Taketani S, Araki M. A novel culture method reveals unique neural stem/progenitors in mature porcine iris tissues that differentiate into neuronal and rod photoreceptor-like cells. Brain Res. 2017;1675:51-60 pubmed publisher
    ..Neuronal differentiation does not require any additives such as fetal bovine serum or FGF2, although FGF2 and IGF2 appeared to promote neural differentiation in the IPE cultures...
  85. Sun D, Yang J, Wang D, Li X, Wang L, Yu Q, et al. Gabapentin regulates expression of FGF2 and FGFR1 in dorsal root ganglia via microRNA-15a in the arthritis rat model. J Orthop Sci. 2017;22:1112-1119 pubmed publisher
    ..in an arthritis rat model, and assess the effect of gabapentin on the expression of fibroblast growth factor 2 (FGF2) and FGF receptor 1 (FGFR1)...
  86. Bendella H, Rink S, Grosheva M, Sarikcioglu L, Gordon T, Angelov D. Putative roles of soluble trophic factors in facial nerve regeneration, target reinnervation, and recovery of vibrissal whisking. Exp Neurol. 2018;300:100-110 pubmed publisher
    ..time course of growth factor expression in the nerves and denervated muscles include (1) an early increase in FGF2 and IGF2, (2) reduced NGF between 2 and 14days after nerve transection and surgical repair, (3) a late rise in BDNF ..
  87. Smallwood P, Munoz Sanjuan I, Tong P, Macke J, Hendry S, Gilbert D, et al. Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996;93:9850-7 pubmed
    ..Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function. ..
  88. Lee M, La W, Park E, Yang H. Synergetic effect of 3,4-dihydroxy-l-phenylalanine-modified poly(lactic-co-glycolic acid) nanopatterned patch with fibroblast growth factor-2 for skin wound regeneration. J Biomed Mater Res B Appl Biomater. 2017;105:594-604 pubmed publisher
    ..as effective adhesion molecules with similar structure as mussel protein, to immobilize fibroblast growth factor-2 (FGF2) on PLGA patches...
  89. Greenblatt M, Shin D, Oh H, Lee K, Zhai B, Gygi S, et al. MEKK2 mediates an alternative β-catenin pathway that promotes bone formation. Proc Natl Acad Sci U S A. 2016;113:E1226-35 pubmed publisher
    ..b>FGF2 activates MEKK2 to phosphorylate β-catenin at serine 675, promoting recruitment of the deubiquitinating enzyme, ..
  90. Yang J, Wang Z, Sinden D, Wang X, Shan B, Yu X, et al. FGF13 modulates the gating properties of the cardiac sodium channel Nav1.5 in an isoform-specific manner. Channels (Austin). 2016;10:410-420 pubmed
    b>FGF13 (FHF2), the major fibroblast growth factor homologous factor (FHF) in rodent heart, directly binds to the C-terminus of the main cardiac sodium channel, NaV1.5...
  91. Paluck S, Nguyen T, Lee J, Maynard H. A Heparin-Mimicking Block Copolymer Both Stabilizes and Increases the Activity of Fibroblast Growth Factor 2 (FGF2). Biomacromolecules. 2016;17:3386-3395 pubmed
    Fibroblast growth factor 2 (FGF2) is a protein involved in cellular functions in applications such as wound healing and tissue regeneration...
  92. Ding X, Gao J, Wang Z, Awada H, Wang Y. A shear-thinning hydrogel that extends in vivo bioactivity of FGF2. Biomaterials. 2016;111:80-89 pubmed publisher
    ..In principle, HELP gel can bind any heparin-binding growth factor; we use fibroblast growth factor-2 (FGF2) in this study to demonstrate its utility...