FGF13

Summary

Gene Symbol: FGF13
Description: fibroblast growth factor 13
Alias: FGF-13, FGF2, FHF-2, FHF2, fibroblast growth factor homologous factor 2
Species: human

Top Publications

  1. ncbi Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE
    Alessandro Foletti
    ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Oncogene 21:1841-7. 2002
  2. ncbi Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
    I Ding
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1002, USA
    Acta Oncol 36:337-40. 1997
  3. ncbi Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows
    C Pfarrer
    Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:758-70. 2006
  4. ncbi Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex
    Gururaj A Rao
    Department of Pharmaceutics, University of Florida, Gainesville, U S A
    J Drug Target 16:79-89. 2008
  5. ncbi Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation
    Jing Zheng
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Perinatal Research Laboratories, PAB1 Meriter Hospital, Madison, WI 53715, USA
    Biol Reprod 78:143-50. 2008
  6. ncbi Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways
    K Wang
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, WI 53715, USA
    Placenta 30:1045-51. 2009
  7. ncbi FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
    Giannoula Soufla
    Department of Virology, Medical School, University of Crete, PO Box 1527, Heraklion 71003, Crete, Greece
    Cancer Lett 259:146-55. 2008
  8. ncbi Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter
    Regina C Armstrong
    Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Neurosci 22:8574-85. 2002
  9. ncbi FGFs-1 and -2, and TGF beta 1 as inductive signals modulating in vitro odontoblast differentiation
    F J Unda
    Departamento de Biologia Celular y Ciencias Morfologicas Facultad de Medicina y Odontologia, Universidad Pais Vasco Euskal Herriko Unibertsitatea, Leioa 48940, Vizcaya, Spain
    Adv Dent Res 15:34-7. 2001
  10. ncbi Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells
    Kai Wang
    Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 79:704-10. 2008

Research Grants

  1. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
  2. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
  3. Action of Anabolic Factors on Bone Formation in Mice
    Marja Hurley; Fiscal Year: 2007
  4. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2010
  5. Action of Anabolic Factors on Bone Formation in Mice
    Marja Hurley; Fiscal Year: 2009
  6. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
  7. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
  8. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
  9. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
  10. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010

Detail Information

Publications138 found, 100 shown here

  1. ncbi Absence of fibroblast growth factor 2 does not prevent tumor formation originating from the RPE
    Alessandro Foletti
    ISREC Swiss Institute for Experimental Cancer Research, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Oncogene 21:1841-7. 2002
    We have analysed the importance of fibroblast growth factor 2 (FGF2) in tumor development...
  2. ncbi Radioprotection of hematopoietic tissue by fibroblast growth factors in fractionated radiation experiments
    I Ding
    Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892-1002, USA
    Acta Oncol 36:337-40. 1997
    ..FGF(1/2) dose was 3 microg per i.v. injection given 24 and 4 hrs before the first radiation dose. FGF2 treated mice had a significant survival advantage over saline-treated mice with a DMF of 1.22 +/- 0.07 (p < 0...
  3. ncbi Fibroblast growth factor (FGF)-1, FGF2, FGF7 and FGF receptors are uniformly expressed in trophoblast giant cells during restricted trophoblast invasion in cows
    C Pfarrer
    Institute for Veterinary Anatomy, Histology and Embryology, Justus Liebig University, D 35392 Giessen, Germany
    Placenta 27:758-70. 2006
    ..b>FGF2 signals dominated in maternal vascular endothelia (VE), immature TGC, and MTC, whereas staining in other cell types ..
  4. ncbi Evaluation of the transfection property of a peptide ligand for the fibroblast growth factor receptor as part of PEGylated polyethylenimine polyplex
    Gururaj A Rao
    Department of Pharmaceutics, University of Florida, Gainesville, U S A
    J Drug Target 16:79-89. 2008
    ..The 7-mer peptide (MQLPLAT), targeted toward the fibroblast growth factor 2 (FGF2) receptor, was recently identified using a phage-display library method as possessing a high degree of specificity ..
  5. ncbi Activation of multiple signaling pathways is critical for fibroblast growth factor 2- and vascular endothelial growth factor-stimulated ovine fetoplacental endothelial cell proliferation
    Jing Zheng
    Department of Obstetrics and Gynecology, University of Wisconsin Madison, Perinatal Research Laboratories, PAB1 Meriter Hospital, Madison, WI 53715, USA
    Biol Reprod 78:143-50. 2008
    Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) are two key regulators of placental angiogenesis...
  6. ncbi Hypoxia enhances FGF2- and VEGF-stimulated human placental artery endothelial cell proliferation: roles of MEK1/2/ERK1/2 and PI3K/AKT1 pathways
    K Wang
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, WI 53715, USA
    Placenta 30:1045-51. 2009
    ..In this study, we examined if hypoxia affected fibroblast growth factor-2 (FGF2)- and vascular endothelial growth factor (VEGF)-stimulated cell proliferation via the mitogen-activated protein ..
  7. ncbi FGF2 transcript levels are positively correlated with EGF and IGF-1 in the malignant endometrium
    Giannoula Soufla
    Department of Virology, Medical School, University of Crete, PO Box 1527, Heraklion 71003, Crete, Greece
    Cancer Lett 259:146-55. 2008
    ..Fibroblast growth factor-2 (FGF2) is also mitogenic for various cell types and is associated with regulation of tumor angiogenesis and metastasis...
  8. ncbi Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter
    Regina C Armstrong
    Department of Anatomy, Physiology, and Genetics at the Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Neurosci 22:8574-85. 2002
    This study takes advantage of fibroblast growth factor 2 (FGF2) knock-out mice to determine the contribution of FGF2 to the regeneration of oligodendrocytes in the adult CNS...
  9. ncbi FGFs-1 and -2, and TGF beta 1 as inductive signals modulating in vitro odontoblast differentiation
    F J Unda
    Departamento de Biologia Celular y Ciencias Morfologicas Facultad de Medicina y Odontologia, Universidad Pais Vasco Euskal Herriko Unibertsitatea, Leioa 48940, Vizcaya, Spain
    Adv Dent Res 15:34-7. 2001
    We have studied the expression of FGF1 and FGF2 during mouse odontogenesis by immunohistochemistry. FGF1 was detected in differentiated odontoblasts and at the secretory pole of ameloblasts...
  10. ncbi Protein phosphatase 3 differentially modulates vascular endothelial growth factor- and fibroblast growth factor 2-stimulated cell proliferation and signaling in ovine fetoplacental artery endothelial cells
    Kai Wang
    Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 79:704-10. 2008
    A critical process for vascular endothelial growth factor (VEGF)- and fibroblast growth factor 2 (FGF2)-regulated cellular function is reversible protein phosphorylation, which is tightly controlled by a balance of protein kinases and ..
  11. ncbi Fibroblast growth factor-2 mRNA expression in the brainstem and spinal cord of normal and chronic spinally transected urodeles
    Marie Moftah
    INSERM U 862, Neurocentre Magendie, Pathophysiology of Spinal Networks, Bordeaux, France
    J Neurosci Res 86:3348-58. 2008
    ..the molecular basis of spinal cord regeneration in urodeles, but it is believed that fibroblast growth factor-2 (FGF2) may play an important role by inducing proliferation of neural progenitor cells...
  12. ncbi Myocardial functional recovery after fibroblast growth factor 2 gene therapy as assessed by echocardiography and magnetic resonance imaging
    Keith A Horvath
    Division of Cardiothoracic Surgery, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Ann Thorac Surg 74:481-6; discussion 487. 2002
    ..of this study was to investigate whether an experimental link could be made between the ability of a novel fibroblast growth factor 2 (FGF2) gene formulation to promote neovascularization, and its ability to restore myocardial function.
  13. ncbi Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway
    Eric Sulpice
    Institut des Vaisseaux et du Sang IVS, Centre de Recherche de l association Claude Bernard, Hopital Lariboisiere, 8 rue Guy Patin, 75475 Paris Cedex 10, France
    Blood 100:3087-94. 2002
    ..the effects of PF-4 on the intracellular signal transduction induced by basic fibroblast growth factor (FGF2)...
  14. ncbi In vivo involvement of heparan sulfate proteoglycan in the bioavailability, internalization, and catabolism of exogenous basic fibroblast growth factor
    S Colin
    Service de Biochimie et Génétique Moléculaire, CEA Saclay, F 91191 Gif sur Yvette Cedex, France
    Mol Pharmacol 55:74-82. 1999
    The in vivo bioavailability of exogenous fibroblast growth factor 2 (FGF2) was studied after i.v. injection of uniformly 14C-labeled FGF2 into young rats. 14C-FGF2 was rapidly accumulated in almost all solid organs within 5 min...
  15. ncbi Immunohistochemical Jun/Fos protein localization and DNA synthesis in rat adrenal cortex after treatment with ACTH or FGF2
    Rozana B F Baccaro
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Cell Tissue Res 328:7-18. 2007
    ..in rat adrenal cortex infused in situ with adrenocorticotropic hormone (ACTH), fibroblast growth factor 2 (FGF2), or both...
  16. ncbi Distribution of cells expressing Jun and Fos proteins and synthesizing DNA in the adrenal cortex of hypophysectomized rats: regulation by ACTH and FGF2
    Thompson Eusebio Pavan Torres
    Department of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508 900, SP, Brazil
    Cell Tissue Res 329:443-55. 2007
    ..The effects of adrenocorticotropic hormone (ACTH) and fibroblast growth factor 2 (FGF2) on Fos and Jun protein expression were investigated, and DNA synthesis was assessed by using bromodeoxyuridine (..
  17. ncbi Uptake of adenoviral vectors via fibroblast growth factor receptors involves intracellular pathways that differ from the targeting ligand
    D K Hoganson
    Selective Genetics, Inc, 11035 Roselle Street, San Diego, California 92121, USA
    Mol Ther 3:105-12. 2001
    ..delivery of adenoviral gene therapy vectors has been achieved by introducing basic fibroblast growth factor (FGF2) onto viral capsids...
  18. ncbi FGF2 plays a key role in embryonic cerebrospinal fluid trophic properties over chick embryo neuroepithelial stem cells
    C Martin
    Departamento de Anatomía y Radiología, Facultad de Medicina, Universidad de Valladolid, C Ramón y Cajal 7, 47005 Valladolid, Spain
    Dev Biol 297:402-16. 2006
    ..Fibroblast growth factor 2 (FGF2) has been involved in the regulation of these processes, and although it has been suggested that they work in an ..
  19. ncbi Focal adhesion kinase (FAK) expression and activation during lens development
    Maria I Kokkinos
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Australia
    Mol Vis 13:418-30. 2007
    ..of FAK expression and tyrosine phosphorylation (Y397) in the developing lens and investigated its regulation by FGF2. We also examined FAK expression and activation during disrupted fiber differentiation in mice expressing a ..
  20. ncbi Action of fibroblast growth factor-2 on the intervertebral disc
    Xin Li
    Department of Biochemistry, Rush University Medical Center, Cohn Research BD 516, 1735 W, Harrison, Chicago, IL 60612, USA
    Arthritis Res Ther 10:R48. 2008
    Fibroblast growth factor 2 (FGF2) is a growth factor that is immediately released after cartilage injury and plays a pivotal role in cartilage homeostasis...
  21. ncbi Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element
    M Bidder
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 39:8917-28. 2000
    ..via protein-DNA interactions at the Ets cognate, and minimally two mechanisms convey MMP1 promoter upregulation by FGF2: (a) transcriptional activation via Fra1/c-Jun containing DNA-protein interactions at the AP1 cognate and (b) ..
  22. ncbi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    Fibroblast growth factor 2 (FGF2; basic fibroblast growth factor, b-FGF) and its main receptor FGFR-1 are important in both hemangiogenesis and lymphangiogenesis...
  23. ncbi Role of hypoxia and extracellular matrix-integrin binding in the modulation of angiogenic growth factors secretion by retinal pigmented epithelial cells
    S A Mousa
    DuPont Pharmaceuticals Company, Wilmington, Delaware 19880 0400, USA
    J Cell Biochem 74:135-43. 1999
    ..of soluble vitronectin, or fibrinogen to RPE cell cultures resulted in a small to moderate increase in VEGF and FGF2 in the media, while each of these growth factors was dramatically increased after addition of thrombospondin 1 (..
  24. ncbi Endogenous FGF-2 is critically important in PTH anabolic effects on bone
    Maria Giovanna Sabbieti
    Department of Comparative Morphology and Biochemistry, University of Camerino, Camerino MC, Italy
    J Cell Physiol 219:143-51. 2009
    ..and fibroblast growth factor-2 (FGF-2) expression in osteoblasts and the anabolic response to PTH is reduced in Fgf2-/- mice...
  25. ncbi Establishment of a functional ovine fetoplacental artery endothelial cell line with a prolonged life span
    Yang Song
    Department of Obstetrics and Gynecology, Perinatal Research Laboratories, University of Wisconsin, Madison, Wisconsin 53715, USA
    Biol Reprod 76:29-35. 2007
    ..These OFPAE cells produce nitric oxide (NO), proliferate, and migrate in response to fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF)...
  26. ncbi Dissection of the odontoblast differentiation process in vitro by a combination of FGF1, FGF2, and TGFbeta1
    F J Unda
    Departamento de Biologia Celular y Ciencias Morfologicas, Facultad de Medicina y Odontologia, Universidad Pais Vasco Euskal Herriko Unibertsitatea, Leioa, Vizcaya, Spain
    Dev Dyn 218:480-9. 2000
    ..of 17-day-old mouse embryos were cultured in the presence of combinations of the following growth factors: FGF1, FGF2, and TGFbeta1...
  27. ncbi Analysis of segregation distortion and association of the bovine FGF2 with fertilization rate and early embryonic survival
    X Wang
    College of Animal Science and Technology, Northwest A and F University, Yangling, Shaanxi 712100, China
    Anim Genet 40:722-8. 2009
    Fibroblast growth factor 2 (FGF2) plays an important role in fertility and early embryo development...
  28. ncbi Site-specific interactions of neurotrophin-3 and fibroblast growth factor (FGF2) in the embryonic development of the mouse cochlear nucleus
    Waheeda A Hossain
    Department of Neuroscience, University of Connecticut Health Center, Farmington, 06030, USA
    J Neurobiol 66:897-915. 2006
    Neurotrophins and FGF2 contribute to formation of the cochlea, but their roles in cochlear nucleus development are unknown...
  29. ncbi The nucleotide analog cidofovir suppresses basic fibroblast growth factor (FGF2) expression and signaling and induces apoptosis in FGF2-overexpressing endothelial cells
    Sandra Liekens
    Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, Belgium
    Mol Pharmacol 71:695-703. 2007
    ..shown that cidofovir inhibits the development of vascular tumors induced by basic fibroblast growth factor (FGF2)-overexpressing endothelial cells (FGF2-T-MAE) in mice...
  30. ncbi Relative role of upstream regulators of Akt, ERK and CREB in NCAM- and FGF2-mediated signalling
    Dorte Kornerup Ditlevsen
    Protein Laboratory, Department of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute, Building 6 2, Blegdamsvej 3, DK 2200 Copenhagen, Denmark
    Neurochem Int 53:137-47. 2008
    ..For comparison, we also evaluated the role of upstream signalling cascades on fibroblast growth factor 2 (FGF2)-mediated phosphorylation of ERK, Akt, and CREB and found that FGF2 required the activity of both FGFR and Src-..
  31. ncbi The protein kinase C pathway mediates cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2
    Stacey L House
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    Am J Physiol Heart Circ Physiol 293:H354-65. 2007
    ..Our laboratory has previously shown that cardiac-specific overexpression of fibroblast growth factor-2 (FGF2) results in increased recovery of contractile function and decreased infarct size following ischemia-reperfusion ..
  32. ncbi Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-γ
    Byung Jae Lee
    Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Exp Mol Med 43:169-78. 2011
    ..Fibroblast growth factor 2 (FGF2), which is the downstream mediator of TGF-β, is important in wound healing...
  33. ncbi FGF2 specifies hESC-derived definitive endoderm into foregut/midgut cell lineages in a concentration-dependent manner
    Jacqueline Ameri
    Stem Cell Center, Department of Laboratory Medicine, Lund University, Lund, Sweden
    Stem Cells 28:45-56. 2010
    ..Studies in lower vertebrates have demonstrated that FGF2 primarily patterns the ventral foregut endoderm into liver and lung, whereas FGF4 exhibits broad anterior-posterior ..
  34. ncbi Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice
    D L Miller
    Department of Microbiology, New York University School of Medicine, New York, New York 10016, USA
    Mol Cell Biol 20:2260-8. 2000
    Fibroblast growth factor 1 (FGF1) and FGF2, the prototypic members of the FGF family of growth factors, have been implicated in a variety of physiological and pathological processes...
  35. ncbi Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage
    Andy J Fischer
    Department of Neuroscience, Ohio State University, Columbus 43210, USA
    Mol Vis 10:973-86. 2004
    ..The purpose of this study was to assay whether growth factors influence the expression of filamentous proteins in Muller glia in the intact retinas of postnatal chickens...
  36. ncbi Fibroblast growth factor 2: from laboratory evidence to clinical application
    Chu Huang Chen
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    Curr Vasc Pharmacol 2:33-43. 2004
    Fibroblast growth factor 2 (FGF2) is expressed ubiquitously in mesodermal and neuroectodermal cells...
  37. ncbi Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury
    Takeshi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 10:462-7. 2004
    To examine the role of fibroblast growth factor 2 (FGF2) in regulating lens cell proliferation and epithelial-mesenchymal transition (EMT) in response to injury.
  38. ncbi Decrease in excitatory neurons, astrocytes and proliferating progenitors in the cerebral cortex of mice lacking exon 3 from the Fgf2 gene
    Kesi Chen
    Child Study Center, Yale University School of Medicine, 230 South Frontage Rd, New Haven, CT 06520, USA
    BMC Neurosci 9:94. 2008
    The Fgf2 gene is expressed in the brain neuroepithelium during embryonic development and in astroglial cells throughout life...
  39. ncbi Fibroblast growth factor 2-induced cytoplasmic asparaginyl-tRNA synthetase promotes survival of osteoblasts by regulating anti-apoptotic PI3K/Akt signaling
    Su Jin Park
    Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, Republic of Korea
    Bone 45:994-1003. 2009
    Fibroblast growth factor 2 (FGF2), the potent bone anabolic agent, regulates the bone development, as well as the growth, remodeling and healing of the fracture...
  40. ncbi FGF2 translationally induced by hypoxia is involved in negative and positive feedback loops with HIF-1alpha
    Caroline Conte
    Institut National de la Sante et de la Recherche Medicale INSERM, U858, Toulouse, France
    PLoS ONE 3:e3078. 2008
    Fibroblast growth factor 2 (FGF2) is a major angiogenic factor involved in angiogenesis and arteriogenesis, however the regulation of its expression during these processes is poorly documented...
  41. ncbi The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury
    Siyun Liao
    Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 48:1245-54. 2010
    Fibroblast growth factor 2 (FGF2) consists of multiple protein isoforms (low [LMW] and high molecular weight [HMW]), which are localized to different cellular compartments, indicating unique biological activity...
  42. ncbi ATP differentially upregulates fibroblast growth factor 2 and transforming growth factor α in neonatal and adult mice: effect on neuroproliferation
    C Jia
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Neuroscience 177:335-46. 2011
    ..hypotheses that ATP induces the synthesis and secretion of two neurotrophic factors, fibroblast growth factor 2 (FGF2) and transforming growth factor alpha (TGFα), and that these neurotrophic factors have a role in inducing ..
  43. ncbi Anti-FGF2 approaches as a strategy to compensate resistance to anti-VEGF therapy: long-pentraxin 3 as a novel antiangiogenic FGF2-antagonist
    Patrizia Alessi
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
    Eur Cytokine Netw 20:225-34. 2009
    ..One proposed mechanism of tumor escape from anti-VEGF therapy is the up-regulation of fibroblast growth factor-2 (FGF2). FGF2 is a pleiotropic, angiogenesis inducer belonging to the family of the heparin-binding FGF growth factors...
  44. ncbi Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis
    D Ribatti
    Department of Human Anatomy, University of Bari Medical School, Bari, Italy
    J Vasc Res 38:389-97. 2001
    Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) exert their angiogenic activity by interacting with endothelial cells in a distinct manner...
  45. ncbi The cardioprotective effect of the low molecular weight isoform of fibroblast growth factor-2: the role of JNK signaling
    Siyun Liao
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Mol Cell Cardiol 42:106-20. 2007
    Our laboratory showed that overexpression of fibroblast growth factor-2 (FGF2) protected the heart against ischemia-reperfusion injury...
  46. ncbi Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2
    Irina Kiprianova
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, D 69120 Heidelberg, Germany
    Exp Neurol 189:252-60. 2004
    ..We have used mice with a null mutation of the fgf2 gene to explore the relevance of endogenous FGF-2 in brain ischemia...
  47. ncbi Extracellular matrix-mediated differentiation of periodontal progenitor cells
    Smit J Dangaria
    Brodie Laboratory for Craniofacial Genetics, Departments of Oral Biology and Orthodontics, UIC College of Dentistry, The University of Illinois at Chicago, Chicago, IL 60565, USA
    Differentiation 78:79-90. 2009
    ..of diseased periodontal tissues, we have tested the effect of periodontal ECM signals, fibroblast growth factor 2 (FGF2), connective tissue growth factor (CTGF), and the cell adhesion peptide Arg-Gly-Asp (RGD) on the differentiation of ..
  48. ncbi Intrathecal injection of epidermal growth factor and fibroblast growth factor 2 promotes proliferation of neural precursor cells in the spinal cords of mice with mutant human SOD1 gene
    Yasuyuki Ohta
    Department of Neurology, Graduate School of Medicine, Dentistry and Pharmacy, Okayama University, Okayama, Japan
    J Neurosci Res 84:980-92. 2006
    ..spinal cord treated with intrathecal infusion of epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF2) into the lumbar spinal cord region of normal and symptomatic transgenic (Tg) mice with a mutant human Cu/Zn ..
  49. ncbi Fibroblast growth factor 2 is more dynamic than vascular endothelial growth factor A during the follicle-luteal transition in the cow
    R S Robinson
    Division of Animal Physiology, University of Nottingham, Loughborough, Leics LE12 5RD, United Kingdom
    Biol Reprod 77:28-36. 2007
    ..we examined the temporal changes in vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and secreted protein, acidic, cysteine-rich (osteonectin) (SPARC) during the follicular-luteal transition and CL ..
  50. ncbi In vivo analysis of oligodendrocyte lineage development in postnatal FGF2 null mice
    Joshua C Murtie
    Program in Molecular and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    Glia 49:542-54. 2005
    Analysis of fibroblast growth factor 2 null (FGF2-/-) and wild-type (FGF2+/+) mice was used to interpret the potential in vivo role of endogenous FGF2 on oligodendrocyte lineage cell (OLC) responses during oligodendrogenesis and ..
  51. ncbi Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons
    Alessia Bachis
    Department of Neuroscience, Georgetown University Medical Center, EP04, New Research Building, 3970 Reservoir Road, NW, Washington, DC 20057, USA
    Neuropharmacology 55:1114-20. 2008
    ..Fibroblast growth factor 2 (FGF2) is a growth factor essential for the proper formation of synaptic connections in the cerebral cortex, maturation ..
  52. ncbi Gene expression profile in fibroblast growth factor 2-transformed endothelial cells
    Patrizia Dell'Era
    Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, 25123 Brescia, Italy
    Oncogene 21:2433-40. 2002
    Fibroblast growth factor-2 (FGF2) exerts paracrine and autocrine functions on endothelial cells...
  53. ncbi Retina regeneration in the chick embryo is not induced by spontaneous Mitf downregulation but requires FGF/FGFR/MEK/Erk dependent upregulation of Pax6
    Jason R Spence
    Department of Zoology, Miami University, Oxford, Ohio 45056, USA
    Mol Vis 13:57-65. 2007
    ..To elucidate the early cellular events that take place during induction of retina regeneration in the embryonic chick, focusing on the relationship between fibroblast growth factor (FGF) signaling and the regulation of Pax6 and Mitf...
  54. ncbi Immunolocalization of FGF1 and FGF2 in the regenerating tail of the lizard Lampropholis guichenoti: implications for FGFs as trophic factors in lizard tail regeneration
    Lorenzo Alibardi
    Department of Biology, University of Bologna, Bologna, Italy
    Acta Histochem 112:459-73. 2010
    ..The presence of fibroblast growth factor-1 (FGF1) and -2 (FGF2) in the regenerating tail of the lizard Lampropholis guichenoti has been studied using immunofluorescence labeling...
  55. ncbi FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase
    Riccardo Caldini
    Department of Experimental Pathology and Oncology, University of Florence, Italy
    J Cell Physiol 202:125-34. 2005
    ..We have analyzed whether poly(ADP-ribose) polymerase activity is involved in basic fibroblast growth factor (FGF2)-mediated upregulation of urokinase-type plasminogen activator (uPA) mRNA...
  56. ncbi Coxsackievirus B3 used as a gene therapy vector to express functional FGF2
    D S Kim
    Department of Biotechnology, The Catholic University of Korea, Bucheon, Korea
    Gene Ther 19:1159-65. 2012
    ..A recombinant CVB3 complementary DNA was constructed by inserting a gene encoding human fibroblast growth factor 2 (FGF2)...
  57. ncbi Effect of syndecan-1, syndecan-4, and glypican-1 on turkey muscle satellite cell proliferation, differentiation, and responsiveness to fibroblast growth factor 2
    S G Velleman
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA USA
    Poult Sci 86:1406-13. 2007
    ..families consisting of the syndecans and glypicans are low-affinity receptors for fibroblast growth factor 2 (FGF2)...
  58. ncbi Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells
    Chai Fei Li
    Laboratory of Cell Growth, Northern California Institute for Research and Education, San Francisco, California, USA
    J Bone Miner Res 21:946-55. 2006
    ..Here, we show that MS induced proliferation in both MC3T3-E1 and BMOp cells isolated from Fgf2(+/+) mice; Fgf2(-/-) BMOp cells required exogenous FGF-2 for a normal proliferation response...
  59. ncbi JNK/ERK/FAK mediate promigratory actions of basic fibroblast growth factor in astrocytes via CCL2 and COX2
    Mathieu P Lichtenstein
    Institut de Neurociencies, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurosignals 20:86-102. 2012
    ..This knowledge gap affects basic fibroblast growth factor (FGF2), which in the brain is mainly produced by astrocytes and characteristically upregulated in reactive astrocytes...
  60. ncbi Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor
    Cristina Ferreras
    Translational Angiogenesis Group, School of Cancer and enabling Sciences, The University of Manchester, Manchester M20 4BX, United Kingdom
    J Biol Chem 287:36132-46. 2012
    Fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor 165 (VEGF(165)) are potent pro-angiogenic growth factors that play a pivotal role in tumor angiogenesis...
  61. ncbi Intraventricular injection of FGF-2 promotes generation of oligodendrocyte-lineage cells in the postnatal and adult forebrain
    Kasum Azim
    Institute of Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael s Building, Portsmouth, United Kingdom Neuromorphology, Brain Research Institute, University of Zürich ETHZ, Zurich, Switzerland
    Glia 60:1977-90. 2012
    b>FGF2 is considered a key factor in the generation of oligodendrocytes (OLs) derived from neural stem cells (NSCs) located within the subventricular zone (SVZ)...
  62. ncbi Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling
    Nadja Jastrebova
    Department of Medical Biochemistry and Microbiology, Uppsala University, SE 751 23 Uppsala, Sweden
    J Biol Chem 285:26842-51. 2010
    ..the structural characteristics of porcine HS in cellular signaling induced by basic fibroblast growth factor (FGF2), using CHO745 cells devoid of endogenous glycosaminoglycans as target...
  63. ncbi Growth factor deprivation induces an alternative non-apoptotic death mechanism that is inhibited by Bcl2 in cells derived from neural precursor cells
    María del Carmen Cárdenas-Aguayo
    Department of Developmental Genetics and Molecular Physiology, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, MOR 62210, Mexico
    J Hematother Stem Cell Res 12:735-48. 2003
    ..We previously showed that fibroblast growth factor-2 (FGF2) could act as a survival factor for neural precursor cells...
  64. ncbi ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts
    Corinne Niger
    Department of Orthopaedics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Am J Physiol Cell Physiol 302:C1035-44. 2012
    ..we have shown that Cx43 can enhance the signaling and transcriptional response to fibroblast growth factor 2 (FGF2) in osteoblasts by increasing protein kinase C-δ (PKCδ) activation to affect Runx2 activity...
  65. ncbi The fibroblast growth factor receptor 1 (FGFR1), a marker of response to chemoradiotherapy in breast cancer?
    Carole Massabeau
    Department of Radiation Oncology, Institut Curie, 26 Rue d Ulm, Paris, 75005, France
    Breast Cancer Res Treat 134:259-66. 2012
    ..of the tyrosine kinase receptor fibroblast growth factor-1 (FGFR1) and its ligand, the fibroblast growth factor 2 (FGF2) in determining the response to chemoradiotherapy of breast cancers...
  66. ncbi Fibroblast growth factors and their specific binding sites in normal urothelium and transitional cell carcinoma (TCC) of the human bladder
    S Palcy
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires EA MRS 415 URA CNRS 1813, Université Paris XII Val de Marne, Creteil, France
    Cell Mol Biol (Noisy-le-grand) 41:565-75. 1995
    In order to further investigate the involvement of FGF1 and FGF2 in the transitional cell carcinoma of the bladder (TCC), we compared the expression of FGF1, FGF2 and their membrane binding sites by biochemical and immunological methods ..
  67. ncbi FGF2 is crucial for the development of bovine luteal endothelial networks in vitro
    Kathryn J Woad
    School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, Leicestershire LE125RD, UK
    Reproduction 138:581-8. 2009
    ..complex interplay between factors such as vascular endothelial growth factor A (VEGFA), fibroblast growth factor 2 (FGF2) and platelet-derived growth factor (PDGF). However, the relative role of these factors remains to be elucidated...
  68. ncbi Gene expression patterns of the fibroblast growth factors and their receptors during myogenesis of rat satellite cells
    S Kastner
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Histochem Cytochem 48:1079-96. 2000
    ..We previously showed that fibroblast growth factor 2 (FGF2, basic FGF) stimulates a greater number of satellite cells to enter the cell cycle but does not modify the overall ..
  69. ncbi Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells
    Maneesh Mailankot
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1802:609-20. 2010
    Fibroblast growth factor-2 (FGF2)-mediated signaling plays an important role in fiber cell differentiation in eye lens...
  70. ncbi Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2
    T Aikawa
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 276:29347-52. 2001
    ..To understand the growth-inhibitory mechanisms of FGF, we analyzed the effects of FGF2 on cell cycle-regulating molecules in chondrocytes...
  71. ncbi Effect of glypican-1 covalently attached chains on turkey myogenic satellite cell proliferation, differentiation, and fibroblast growth factor 2 responsiveness
    Y Song
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Poult Sci 89:123-34. 2010
    ..The glypican-1 GAG chains are required for cell differentiation and responsiveness to fibroblast growth factor 2 (FGF2). The role of glypican-1 N-glycosylated chains in regulating cell activities has not been reported...
  72. ncbi Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO
    Liping Xiao
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 285:2834-46. 2010
    b>FGF2 transgenic mice were developed in which type I collagen regulatory sequences drive the nuclear high molecular weight FGF2 isoforms in osteoblasts (TgHMW)...
  73. ncbi Sugar-induced modification of fibroblast growth factor 2 reduces its angiogenic activity in vivo
    Francesco Facchiano
    Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, Roma, Italy
    Am J Pathol 161:531-41. 2002
    ..The major aims of the present study were to evaluate the effect of hyperglycemia on fibroblast growth factor 2 (FGF2)-induced angiogenesis in vivo and to determine whether FGF2 non-enzymatic glycation occurs in hyperglycemic mice...
  74. ncbi Influence of FGF2 and PEG hydrogel matrix properties on hMSC viability and spreading
    William J King
    Department of Biomedical Engineering, University of Wisconsin, 1550 Engineering Drive, Madison, Wisconsin 53706, USA
    J Biomed Mater Res A 93:1110-23. 2010
    ..poly(ethylene glycol) (PEG) hydrogel arrays were used to screen for the effects of fibroblast growth factor-2 (FGF2), combined with multiple hydrogel matrix parameters, on human mesenchymal stem cell (hMSC) viability and spreading...
  75. ncbi An intrinsic quality-control mechanism ensures unconventional secretion of fibroblast growth factor 2 in a folded conformation
    Lucía Cespón Torrado
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Cell Sci 122:3322-9. 2009
    Fibroblast growth factor 2 (FGF2) is a proangiogenic mitogen that is secreted by an unconventional mechanism, which does not depend on a functional ER-Golgi system...
  76. ncbi Fibroblast growth factor 2 induces increased calvarial osteoblast proliferation and cranial suture fusion
    Amr M Moursi
    Department of Pediatric Dentistry, College of Dentistry, Pediatric Dentistry, Ohio State University, Columbus, Ohio 43218 2357, USA
    Cleft Palate Craniofac J 39:487-96. 2002
    ..The purpose of this study was to quantitatively determine the effect of FGF2 on rat calvarial osteoblasts and a rat cranial suture formation model.
  77. ncbi Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis
    Shi Lu Chia
    Imperial College London, London, UK
    Arthritis Rheum 60:2019-27. 2009
    ..In vitro, FGF-2 suppresses interleukin-1-driven aggrecanase activity in human cartilage explants, suggesting a chondroprotective role in vivo. We undertook this study to investigate the in vivo role of FGF-2 in murine cartilage...
  78. ncbi In vivo infusions of exogenous growth factors into the fourth ventricle of the adult mouse brain increase the proliferation of neural progenitors around the fourth ventricle and the central canal of the spinal cord
    David J Martens
    Department of Anatomy and Cell Biology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Toronto, ON, M5S 1A8, Canada
    Eur J Neurosci 16:1045-57. 2002
    ..from the fourth ventricle and spinal cord form neurospheres in vitro in response to basic fibroblast growth factor (FGF2)+heparin (H) or epidermal growth factor (EGF)+FGF2 together...
  79. ncbi Polymorphisms in the FGF2 gene and risk of serous ovarian cancer: results from the ovarian cancer association consortium
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 12:269-75. 2009
    ..We hypothesized that common single nucleotide polymorphisms (SNPs) in the FGF2 gene may alter angiogenic potential and thereby susceptibility to ovarian cancer...
  80. ncbi A new role for FGF2 as an endogenous inhibitor of anxiety
    JAVIER A PEREZ
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 29:6379-87. 2009
    Human postmortem studies have demonstrated that fibroblast growth factor-2 (FGF2) expression is decreased in the brain of depressed individuals...
  81. ncbi Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells
    Ghida Harfouche
    CEA, IRCM, Laboratory of Genomics and Radiobiology of Keratinopoiesis, Evry, France
    Stem Cells 28:1639-48. 2010
    ..Data revealed that several genes of the fibroblast growth factor type 2 (FGF2) signaling pathway were induced by DNA damage in stem cells and not in progenitors...
  82. ncbi HMGA proteins regulate the expression of FGF2 in uterine fibroids
    Burkhard Maria Helmke
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Mol Hum Reprod 17:135-42. 2011
    ..b>FGF2 (fibroblast growth factor 2) was one of these genes, and we were then able to show by microarray analyses that ..
  83. ncbi Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development
    P M Smallwood
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:9850-7. 1996
    ..Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function...
  84. ncbi Expression of chicken fibroblast growth factor homologous factor (FHF)-1 and of differentially spliced isoforms of FHF-2 during development and involvement of FHF-2 in chicken limb development
    I Munoz-Sanjuan
    Department of Molecular Biology and Genetics, Department of Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Development 126:409-21. 1999
    ..Finally, we show that a secreted version of cFHF-2 activates the expression of HoxD13, HoxD11, Fgf-4 and BMP-2 ectopically, consistent with cFHF-2 playing a role in anterior-posterior patterning of the limb...
  85. ncbi Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway
    Yurong Fei
    University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Biol Chem 286:40575-83. 2011
    Fibroblast growth factor 2 (FGF2) positively modulates osteoblast differentiation and bone formation. However, the mechanism(s) is not fully understood...
  86. ncbi Expansion of mesenchymal stem cells on fibrinogen-rich protein surfaces derived from blood plasma
    John D Kisiday
    Department of Clinical Science, Colorado State University, Fort Collins, CO, USA
    J Tissue Eng Regen Med 5:600-11. 2011
    ..cells/cm(2) and passaged five times over 10 days, MSCs on FRP in medium containing fibroblast growth factor 2 (FGF2) resulted in a ∼2.5-fold increase in cell yield relative to TCP. In FGF2-free medium, FRP stimulated a 10...
  87. ncbi FGF and ERK signaling coordinately regulate mineralization-related genes and play essential roles in osteocyte differentiation
    Ai Kyono
    Department of Orthopaedics, Case Western Reserve University, 2109 Adelbert Road BRB 329, Cleveland, OH 44106, USA
    J Bone Miner Metab 30:19-30. 2012
    ..This experiment identified a number of mineralization-related genes that were regulated by FGF2 in an ERK MAPK-dependent manner...
  88. ncbi Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential
    Wendy R Zeng
    Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, Parkville, Victoria, Australia
    Neurochem Int 59:394-403. 2011
    ..When cultured in EGF and FGF2, ESC-derived NS cells have been reported to be stable and multipotent...
  89. ncbi Purine analogue 6-methylmercaptopurine riboside inhibits early and late phases of the angiogenesis process
    M Presta
    Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Italy
    Cancer Res 59:2417-24. 1999
    ..6-MMPR inhibited fibroblast growth factor-2 (FGF2)-induced proliferation and delayed the repair of mechanically wounded monolayer in endothelial GM 7373 cell ..
  90. ncbi Proliferation of intimal smooth muscle cells. Attenuation of basic fibroblast growth factor 2-stimulated proliferation is associated with increased expression of cell cycle inhibitors
    N E Olson
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 275:11270-7. 2000
    Basic fibroblast growth factor (FGF2) is a potent mitogen for medial smooth muscle cells and is necessary for their proliferation after balloon catheter injury; however, intimal smooth muscle cells do not require FGF2 for their ..
  91. ncbi Fibroblast growth factor requirements for in vitro development of bovine embryos
    Sarah D Fields
    Department of Animal Sciences, University of Florida, Gainesville, FL, USA
    Theriogenology 75:1466-75. 2011
    ..1 ± 27.5 vs 297.8 ± 25.0). A second series of studies determined if supplemental FGF2 enhances development in vitro...
  92. ncbi Basic fibroblast growth factor (Fgf2) is necessary for cell proliferation and neurogenesis in the developing cerebral cortex
    R Raballo
    Child Study Center and Section of Neurobiology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 20:5012-23. 2000
    ..We have previously shown that the germline mutation of the basic fibroblast growth factor (Fgf2) gene results in a reduction in the number of cortical neurons in the adult...
  93. ncbi Interaction of clodronate with fibroblast growth factor 2 reduces FGF2-activity in endothelial cells
    K Rose
    Institut fur Pharmazeutische und Medizinische Chemie, Westfalische Wilhelms Universitat Munster, Hittorfstr, 58 62, 48149 Munster, Germany
    Biomed Pharmacother 65:46-51. 2011
    ..Furthermore, ATP-binding to FGF2 also leads to stabilization of this growth factor as discovered recently...
  94. ncbi Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin
    Suk Ho Bhang
    School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea
    Biotechnol Lett 33:845-51. 2011
    Fibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of ..
  95. ncbi Molecular disruption of NBS1 with targeted gene delivery enhances chemosensitisation in head and neck cancer
    K Araki
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, 415 Curie Boulevard, CRB Room 145, Philadelphia, PA 19104, USA
    Br J Cancer 103:1822-30. 2010
    a fibroblast growth factor 2 (FGF2)-targeted adenoviral system can alter viral tropism and allow for improved transduction and reduced systemic toxicity...
  96. ncbi Hypoxia induces FGF2 production by vascular endothelial cells and alters MMP9 and TIMP1 expression in extravillous trophoblasts and their invasiveness in a cocultured model
    Jianying Luo
    Department of Obstetrics and Gynecology, Northern Jiangsu Province Hospital, Clinical Medical College, Yangzhou University, Jiangsu, China
    J Reprod Dev 57:84-91. 2011
    The role of fibroblast growth factor 2 (FGF2) secretion by vascular endothelial cells during trophoblast invasion was assessed...
  97. ncbi Arginine vasopressin inhibition of cyclin D1 gene expression blocks the cell cycle and cell proliferation in the mouse Y1 adrenocortical tumor cell line
    Telma T Schwindt
    Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo SP, 05508 900, Brazil
    Biochemistry 42:2116-21. 2003
    ..In G0/G1-arrested mouse Y1 adrenocortical tumor cells, maintained in serum-free medium (SFM), AVP mimics FGF2, promoting rapid ERK1/2 activation (5 min) followed by c-Fos protein induction (2 h)...
  98. ncbi Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis
    Dianhua Qiao
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Clinical Sciences Center K4 850, Madison, WI 53562 8550, USA
    J Biol Chem 278:16045-53. 2003
    Fibroblast growth factor-2 (FGF2) is a potent angiogenic factor in gliomas. Heparan sulfate promotes ligand binding to receptor tyrosine kinase and regulates signaling...
  99. ncbi AP1 binding site is another target of FGF2 regulation of bone sialoprotein gene transcription
    Hideki Takai
    Department of Periodontology, Nihon University School of Dentistry at Matsudo, Chiba, Japan
    Gene 410:97-104. 2008
    ..We previously reported that fibroblast growth factor 2 (FGF2) regulates BSP gene transcription via FGF2 response element (FRE) in the proximal promoter of rat BSP gene...

Research Grants90

  1. Antidepressants and Fibroblast Growth Factor
    Italo Mocchetti; Fiscal Year: 2006
    ..by preliminary data showing that antidepressants increase the synthesis of basic fibroblast growth factor (FGF2), a neurotrophic factor that exerts neurotrophic activity on catecholaminergic neurons and promotes neurogenesis in ..
  2. REGULATION OF CRANIALSUTURE MORPHOGENESIS
    Roy Ogle; Fiscal Year: 2002
    ..The hypotheses are that certain FGFs released from bone matrix (FGF2), the suture cells, and the dura mater (other that FGF2 or 7) diffuse to the extracellular matrix of the developing ..
  3. Action of Anabolic Factors on Bone Formation in Mice
    Marja Hurley; Fiscal Year: 2007
    ..serum calcium and to increase bone formation in vivo are all significantly reduced in mice with disruption of the Fgf2 gene suggesting an important physiologic role for endogenous FGF-2 in some of the responses to PTH in bone...
  4. Action of Anabolic Factors on Bone Formation in Mice
    MARJA MARIE HURLEY; Fiscal Year: 2010
    ..that in addition to its role in promoting osteoblast (OB) function and bone formation, fibroblast growth factor 2 (FGF2) is a negative regulator of mesenchymal stem cell differentiation into mature adipocytes (AD)...
  5. Action of Anabolic Factors on Bone Formation in Mice
    Marja Hurley; Fiscal Year: 2009
    ..that in addition to its role in promoting osteoblast (OB) function and bone formation, fibroblast growth factor 2 (FGF2) is a negative regulator of mesenchymal stem cell differentiation into mature adipocytes (AD)...
  6. FIBROBLAST GROWTH FACTORS IN INFLAMMATORY BOWEL DISEASE
    Steven Cohn; Fiscal Year: 2002
    ..expression of FGF-2, Cox-1, Cox-2, Bcl related genes, prostaglandin synthesis and apoptosis in wild-type mice and FGF2 -/- mice treated at various times following systemic treatment with anti-CD3 or in DO11...
  7. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..Basic Fibroblast growth factor (FGF2) is expressed by cortical progenitor cells and increases their proliferation both in vitro and in vivo...
  8. MAP KINASE REGULATION OF OSTEOBLAST FUNCTION
    Renny Franceschi; Fiscal Year: 2007
    ..Other factors such as FGF2, IGF-1 and mechanical stimulation, known to signal through MARK, also stimulate RUNX2 phosphorylation...
  9. Regulation of Mandibular Condylar Cartialage Growth
    Robert Hinton; Fiscal Year: 2006
    ..We will test the hypothesis that mediators of Fgf2 and Tgf-Beta2 activity are the same in MCC and SUT, and that they differ from mediators of Fgf2 and Tgf-Beta2 ..
  10. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010
    ..Importantly, our preliminary data in FGF2-I- mice demonstrates that it is possible to overcome chronic lesion effects on endogenous oligodendrocyte lineage ..
  11. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    REGINA ARMSTRONG; Fiscal Year: 2007
    ..Importantly, our preliminary data in FGF2-/- mice demonstrates that it is possible to overcome chronic lesion effects on endogenous oligodendrocyte lineage ..
  12. Effects of HIV PIs on CNS endothelial cells in NeuroAIDS
    TERESA LANGFORD; Fiscal Year: 2007
    ..PI exposure on the CEC's ability to respond to host-derived growth factors, such as fibroblast growth factor 2 (FGF2), that are generated as defense mechanisms against HIV proteins _resent in the blood stream at viral rebound...
  13. ROLE OF FIBROBLAST GROWTH FACTORS IN PROSTATE GROWTH
    Michael Ittmann; Fiscal Year: 2003
    ..The investigators have shown increased expression of FGF7 and FGF2 in BPH that is correlated with epithelial and stromal proliferation, respectively...
  14. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2010
    ..Studies performed in this funding period show that rPAI-123 inhibits fibroblast growth factor-2 (FGF2) signaling pathways and functions...
  15. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    MARY MULLIGAN KEHOE; Fiscal Year: 2009
    ..Studies performed in this funding period show that rPAI-123 inhibits fibroblast growth factor-2 (FGF2) signaling pathways and functions...
  16. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Everall; Fiscal Year: 2007
    ..data) a significant decrease in the frontal cortical gene expression of somatostatin, fibroblast growth factor-2 (FGF2) and growth arrest and DNA-damage-inducible-beta (GADD45B), and an increase in gene expression of serum/..
  17. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Everall; Fiscal Year: 2006
    ..data) a significant decrease in the frontal cortical gene expression of somatostatin, fibroblast growth factor-2 (FGF2) and growth arrest and DNA-damage-inducible-beta (GADD45B), and an increase in gene expression of serum/..
  18. Mechanisms of PAI-1 Induced Anti-Angiogenesis
    Mary J Mulligan Kehoe; Fiscal Year: 2011
    ..Studies performed in this funding period show that rPAI-123 inhibits fibroblast growth factor-2 (FGF2) signaling pathways and functions...
  19. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..data) a significant decrease in the frontal cortical gene expression of somatostatin, fibroblast growth factor-2 (FGF2) and growth arrest and DNA-damage-inducible-beta (GADD45B), and an increase in gene expression of serum/..
  20. Roles of FGF2 and TGFbeta in cardiac hypertrophy
    Thomas Doetschman; Fiscal Year: 2005
    Roles of FGF2 and TGFbeta1 in cardiac hypertrophy...
  21. FGF2 IN VASCULAR DISEASE
    Michael Reidy; Fiscal Year: 2001
    ..to quantitate the role of a gene in vivo by directly comparing the behavior of cells which can or cannot express FGF2 or FGFR1...
  22. Retinal gene expression changes during oxidative damage
    NAEL AL ABDULLA; Fiscal Year: 2007
    ..Expression of fibroblast growth factor 2 (FGF2) or brain-derived neurotrophic factor (BDNF) in the retina prevents hyperoxia-induced retinal degeneration...
  23. Identification of Sulfs as therapeutic targets for the treatment of age-impaired
    Xingbin Ai; Fiscal Year: 2010
    ..Aged skeletal muscle has reduced levels of FGF2 and elevated Wnts and TGF2, leading to decreased proliferation of resident stem cells (so called satellite cells) ..
  24. Recombinant Polymers for Systemic Cancer Gene Therapy
    Peter Swann; Fiscal Year: 2007
    ..the polymeric backbone, lysine (K) residues to condense plasmid DMA, a targeting ligand (fibroblast growth factor, FGF2) for biorecognition by cancer cells, histidine (H) residues to allow escape from the endosomes, and cysteine (C) ..
  25. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2007
    ..kinetics of clearance of tagged Ap from the CP-CSF in aging and after flow inhibition induced by acetazolamide or FGF2, and Hi) characterize the age-modified expression of the Ap transporters, LRP-1 and the receptor for advanced ..
  26. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..kinetics of clearance of tagged Ap from the CP-CSF in aging and after flow inhibition induced by acetazolamide or FGF2, and Hi) characterize the age-modified expression of the Ap transporters, LRP-1 and the receptor for advanced ..
  27. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..kinetics of clearance of tagged Ap from the CP-CSF in aging and after flow inhibition induced by acetazolamide or FGF2, and Hi) characterize the age-modified expression of the Ap transporters, LRP-1 and the receptor for advanced ..
  28. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Johanson; Fiscal Year: 2009
    ..kinetics of clearance of tagged Ap from the CP-CSF in aging and after flow inhibition induced by acetazolamide or FGF2, and Hi) characterize the age-modified expression of the Ap transporters, LRP-1 and the receptor for advanced ..
  29. Mechanistic Role of NELL-1 in Premature Suture Closure
    Kang Ting; Fiscal Year: 2003
    ..CBFA1 has recently been shown to play an important role in FGFR1 induced CS. TGF-beta1 and FGF2, which affect CBFA1 expression and induce cranial suture closure, induce NELL-1 expression in FRCC cells...
  30. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2010
    ..cortical morphogenesis will be compared amongst mice lacking Fgfr2 versus mice with a combined deletion of Fgfr1, Fgf2 and Fgf3...
  31. HUMAN HEPATOCYTE GROWTH FACTORS
    WALLACE MC KEEHAN; Fiscal Year: 2006
    ..Whether FGF1 and/or FGF2 ablation in mice impacts compensatory growth of liver, cholesterol/bile acid metabolism and response to CCI4 damage ..
  32. GROWTH PLATE CELLULAR FUNCTION FOLLOWING RADIOTHERAPY
    Timothy Damron; Fiscal Year: 2007
    ..have suggested that the potential for recovery following growth plate injury is driven by PTHrP primarily, and by FGF2 and TGF-b secondarily...