Gene Symbol: FGF10
Description: fibroblast growth factor 10
Alias: fibroblast growth factor 10, FGF-10, keratinocyte growth factor 2, produced by fibroblasts of urinary bladder lamina propria
Species: human
Products:     FGF10

Top Publications

  1. Rohmann E, Brunner H, Kayserili H, Uyguner O, Nurnberg G, Lew E, et al. Mutations in different components of FGF signaling in LADD syndrome. Nat Genet. 2006;38:414-7 pubmed
    ..FGFR3) in LADD families, and in one further LADD family, we detected a mutation in the gene encoding fibroblast growth factor 10 (FGF10), a known FGFR ligand...
  2. Milunsky J, Zhao G, Maher T, Colby R, Everman D. LADD syndrome is caused by FGF10 mutations. Clin Genet. 2006;69:349-54 pubmed
    ..Loss of function mutations in FGF10 were recently described in aplasia of the lacrimal and salivary glands [ALSG (MIM 180920; MIM 103420)] (Entesarian ..
  3. Entesarian M, Dahlqvist J, Shashi V, Stanley C, Falahat B, Reardon W, et al. FGF10 missense mutations in aplasia of lacrimal and salivary glands (ALSG). Eur J Hum Genet. 2007;15:379-82 pubmed
    ..Mutations in FGF10 were recently described in ALSG and in lacrimo-auriculo-dento-digital (LADD) syndrome which are overlapping ..
  4. Nomura S, Yoshitomi H, Takano S, Shida T, Kobayashi S, Ohtsuka M, et al. FGF10/FGFR2 signal induces cell migration and invasion in pancreatic cancer. Br J Cancer. 2008;99:305-13 pubmed publisher
    ..b>Fibroblast growth factor 10 induced cell migration and invasion of CFPAC-1 and AsPC-1 pancreatic cancer cells through interaction ..
  5. Klar J, Blomstrand P, Brunmark C, Badhai J, Håkansson H, Brange C, et al. Fibroblast growth factor 10 haploinsufficiency causes chronic obstructive pulmonary disease. J Med Genet. 2011;48:705-9 pubmed publisher
    ..The fibroblast growth factor 10 (FGF10) signalling pathway is critical for lung development and lung epithelial renewal...
  6. Igarashi M, Finch P, Aaronson S. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J Biol Chem. 1998;273:13230-5 pubmed
    ..These results indicate that FGF-10 and KGF have similar receptor binding properties and target cell specificities, but are differentially regulated by components of the extracellular matrix. ..
  7. Sekine K, Ohuchi H, Fujiwara M, Yamasaki M, Yoshizawa T, Sato T, et al. Fgf10 is essential for limb and lung formation. Nat Genet. 1999;21:138-41 pubmed
    ..In particular, Fgf10 is predicted to function as a regulator of brain, lung and limb development on the basis of its spatiotemporal ..
  8. Entesarian M, Matsson H, Klar J, Bergendal B, Olson L, Arakaki R, et al. Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat Genet. 2005;37:125-7 pubmed
    ..We mapped ALSG to 5p13.2-5q13.1, which coincides with the gene fibroblast growth factor 10 (FGF10)...
  9. Riley B, Mansilla M, Ma J, Daack Hirsch S, Maher B, Raffensperger L, et al. Impaired FGF signaling contributes to cleft lip and palate. Proc Natl Acad Sci U S A. 2007;104:4512-7 pubmed
    ..regions and performed association testing on 12 genes (FGFR1, FGFR2, FGFR3, FGF2, FGF3, FGF4, FGF7, FGF8, FGF9, FGF10, FGF18, and NUDT6) and used protein structure analyses to predict the function of amino acid variants...

More Information

Publications118 found, 100 shown here

  1. Shams I, Rohmann E, Eswarakumar V, Lew E, Yuzawa S, Wollnik B, et al. Lacrimo-auriculo-dento-digital syndrome is caused by reduced activity of the fibroblast growth factor 10 (FGF10)-FGF receptor 2 signaling pathway. Mol Cell Biol. 2007;27:6903-12 pubmed
    ..Genetic studies have implicated heterozygous mutations in fibroblast growth factor 10 (FGF10) and in FGF receptor 2 (FGFR2) in LADD syndrome...
  2. Hsi E, Chen K, Chang W, Yu M, Liang C, Juo S. A functional polymorphism at the FGF10 gene is associated with extreme myopia. Invest Ophthalmol Vis Sci. 2013;54:3265-71 pubmed publisher
    Fibroblast growth factor-10 (FGF10) can modulate extracellular matrix associated genes and, therefore, it could be a myopia susceptibility gene...
  3. Yousaf R, Meng Q, Hufnagel R, Xia Y, Puligilla C, Ahmed Z, et al. MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells. Dis Model Mech. 2015;8:1543-53 pubmed publisher
    ..Loss of MAP3K1 function resulted in the downregulation of Fgfr3, Fgf8, Fgf10 and Atf3 expression in the inner ear...
  4. Wu L, Liu C, Jiang M, Jiang Y, Wang Q, Lu Z, et al. Defective eyelid leading edge cell migration in C57BL/6-corneal opacity mice with an "eye open at birth" phenotype. Genet Mol Res. 2016;15: pubmed publisher
    ..mice, adenosine was inserted into the untranslated regions, between 3030 and 3031, in the mRNA 3'-terminal of Fgf10. In addition, guanine 7112 was substituted by adenine in the Mtap1B mRNA, and an A2333T mutation was identified in ..
  5. Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, et al. HIF-1? in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance. Diabetes. 2016;65:3649-3659 pubmed
    ..cells of HIF-1?-deficient mice expressed higher levels of angiogenic factors, including Vegfa, Angpt1, Fgf1, and Fgf10 in accordance with preferable eWAT remodeling...
  6. Chambers K, Pearson J, Aziz N, O Toole P, Garrod D, Lang S. Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics. PLoS ONE. 2011;6:e18796 pubmed publisher
    ..The upregulated growth factors TGFβ2, CXCL12 and FGF10 were selected for further analysis because of previous associations with morphology...
  7. Kamiunten T, Ideno H, Shimada A, Arai Y, Terashima T, Tomooka Y, et al. Essential roles of G9a in cell proliferation and differentiation during tooth development. Exp Cell Res. 2017;357:202-210 pubmed publisher
    ..In addition, expression of Fgf3 and Fgf10 in the mesenchyme was decreased in G9a cKO mice at P0...
  8. Boucherat O, Landry Truchon K, Bérubé Simard F, Houde N, Beuret L, Lezmi G, et al. Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development. 2015;142:2981-95 pubmed publisher
    ..of Shh, a transcriptional target of YY1, in lung endoderm, and the subsequent derepression of mesenchymal Fgf10 expression. Accordingly, SHH supplementation partially rescued the lung phenotype in vitro...
  9. Pan N, Jahan I, Kersigo J, Kopecky B, Santi P, Johnson S, et al. Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti. Hear Res. 2011;275:66-80 pubmed publisher
    ..that the organ of Corti is reduced to two rows of cells wedged between flanking markers of the organ of Corti (Fgf10 and Bmp4). These two rows of cells (instead of five rows of supporting cells) are positive for Prox1 in neonates...
  10. Tribulo P, Siqueira L, Oliveira L, Scheffler T, Hansen P. Identification of potential embryokines in the bovine reproductive tract. J Dairy Sci. 2018;101:690-704 pubmed publisher
    ..estrous cycle for 21 genes with 11 genes having highest expression at estrus (CCL21, CTGF, CXCL10, CXCL16, DKK3, FGF10, IL18, IL33, IL34, PGF, and SFRP2), 1 gene at d 3 (WNT4), 8 at d 5 (BMP7, HGF, IL6, SFRP1, TGFB1, WIF1, WNT2, and ..
  11. Yan Z, Chen G, Yang Y, Sun L, Jiang Z, Feng L, et al. Expression and roles of syndecan-4 in dental epithelial cell differentiation. Int J Mol Med. 2014;34:1301-8 pubmed publisher
    ..Fibroblast growth factor 10 (FGF10) promoted proliferation and slightly decreased cell differentiation...
  12. Mardaryev A, Ahmed M, Vlahov N, Fessing M, Gill J, Sharov A, et al. Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J. 2010;24:3869-81 pubmed publisher
    ..Microarray, qRT-PCR and Western blot analyses revealed that miR-31 negatively regulates expression of Fgf10, the components of Wnt and BMP signaling pathways Sclerostin and BAMBI, and Dlx3 transcription factor, as well as ..
  13. Takahashi T, Friedmacher F, Zimmer J, Puri P. Expression of T-box transcription factors 2, 4 and 5 is decreased in the branching airway mesenchyme of nitrofen-induced hypoplastic lungs. Pediatr Surg Int. 2017;33:139-143 pubmed publisher
    ..Immunofluorescence double staining for Tbx2, Tbx4 and Tbx5 was combined with the mesenchymal marker Fgf10 to assess protein expression and localization in branching airway tissue...
  14. Lv Y, Wang Y, Sun J, Gong C, Chen Y, Su G, et al. MicroRNA profiles of fibroblasts derived from in vivo fertilized and fat-1 transgenic cattle. Gene. 2017;636:70-77 pubmed publisher
    ..Overexpression of one of these miRNAs, miR-21-5p, was found to suppress expression of fibroblast growth factor 10 (FGF10) and adipose triglyceride lipase (ATGL) in fibroblasts from TG cattle and 3T3-L1 pre-adipocytes...
  15. Kyrou I, Weickert M, Gharanei S, Randeva H, Tan B. Fibroblast growth factors: new insights, new targets in the management of diabetes. Minerva Endocrinol. 2017;42:248-270 pubmed publisher
    ..Over the past decade certain FGFs (e.g. FGF1, FGF10, FGF15/FGF19 and FGF21) have been further recognized as regulators of energy homeostasis, metabolism and ..
  16. Lahtela J, Pradhan B, Närhi K, Hemmes A, Sarkioja M, Kovanen P, et al. The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis. Dis Model Mech. 2015;8:393-401 pubmed publisher
    ..the partial loss of EphA3 leads only to subtle changes in epithelial Nkx2-1, endothelial Cd31 and mesenchymal Fgf10 RNA expression levels, and no macroscopic phenotypic effects on lung epithelial branching, mesenchymal cell ..
  17. Li Q, Alsaidan O, Ma Y, Kim S, Liu J, Albers T, et al. Pharmacologically targeting the myristoylation of the scaffold protein FRS2α inhibits FGF/FGFR-mediated oncogenic signaling and tumor progression. J Biol Chem. 2018;293:6434-6448 pubmed publisher
    ..2 (FRS2α), a scaffold protein essential for FGFR signaling, inhibits FGF/FGFR-mediated oncogenic signaling and FGF10-induced tumorigenesis...
  18. Thimraj T, Birru R, Mitra A, Schulz H, Leikauf G, Ganguly K. Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular. Lung. 2017;195:263-270 pubmed publisher
    ..lymphoid enhancer binding factor 1 (Lef1), also increased along with its downstream targets Fgf2, Fgf7, and Fgf10 in the lungs of Sod3-/- mice...
  19. Zhu Y, Li E, Sun W, Xu D, Liu Z, Zhao W, et al. Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring. Reprod Toxicol. 2016;61:169-76 pubmed publisher
    ..Further, decreased mRNA levels of Shh, Fgf10, Gli2, Gli3, Bmp4, Wnt5a, Hoxa13, Hoxd13, Fgfr2 and AR were observed in TR and GT in the ARMs & hypospadias ..
  20. Paradise C, Galeano Garces C, Galeano Garces D, Dudakovic A, Milbrandt T, Saris D, et al. Molecular characterization of physis tissue by RNA sequencing. Gene. 2018;668:87-96 pubmed publisher
    ..MATN1, MATN2, MATN3), and signaling proteins in the WNT pathway (WNT10B, FZD1, FZD10, DKK2) or the FGF pathway (FGF10, FGFR4)...
  21. Shibuya M, Ikari T, Sugiyama G, Ohyama Y, Kumamaru W, Nagano K, et al. Efficient regulation of branching morphogenesis via fibroblast growth factor receptor 2c in early-stage embryonic mouse salivary glands. Differentiation. 2016;92:216-224 pubmed publisher
    ..Interestingly, FGFR2c signaling also led to increased fgf10 expression, and this increase was suppressed by the NA...
  22. Meng T, Huang Y, Wang S, Zhang H, Dechow P, Wang X, et al. Twist1 Is Essential for Tooth Morphogenesis and Odontoblast Differentiation. J Biol Chem. 2015;290:29593-602 pubmed publisher
    ..Furthermore, in vitro ChIP assays demonstrated that Twist1 was able to bind to a specific region of the Fgf10 promoter...
  23. Meyerholz D, Stoltz D, Gansemer N, Ernst S, Cook D, Strub M, et al. Lack of cystic fibrosis transmembrane conductance regulator disrupts fetal airway development in pigs. Lab Invest. 2018;98:825-838 pubmed publisher
    ..We studied primary pig airway epithelial cell cultures and found that FGF10 increased cellular proliferation (non-CF and CF) and CFTR expression/function (in non-CF only)...
  24. Luo Y, El Agha E, Turcatel G, Chen H, Chiu J, Warburton D, et al. Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. BMC Biol. 2015;13:42 pubmed publisher
    ..Moreover, lung epithelial branching morphogenesis was drastically inhibited due to disrupted Bmp4-Fgf10 morphogen production and regulation in surrounding lung mesenchyme...
  25. Adine C, Ng K, Rungarunlert S, Souza G, Ferreira J. Engineering innervated secretory epithelial organoids by magnetic three-dimensional bioprinting for stimulating epithelial growth in salivary glands. Biomaterials. 2018;180:52-66 pubmed publisher
    ..Next, a SG epithelial differentiation stage was completed with fibroblast growth factor 10 (4-400?ng/ml) to recapitulate SG epithelial morphogenesis and neurogenesis...
  26. Abashev T, Metzler M, Wright D, Sandell L. Retinoic acid signaling regulates Krt5 and Krt14 independently of stem cell markers in submandibular salivary gland epithelium. Dev Dyn. 2017;246:135-147 pubmed publisher
    ..Moreover, we demonstrate that inhibition of RA signaling represses cell proliferation and expression of FGF10 signaling targets, and upregulates expression of basal epithelial keratins Krt5 and Krt14...
  27. Caprioli A, Villasenor A, Wylie L, Braitsch C, Marty Santos L, Barry D, et al. Wnt4 is essential to normal mammalian lung development. Dev Biol. 2015;406:222-34 pubmed publisher
    ..In addition, we observe reduction of the important lung growth factors Fgf9, Fgf10, Sox9 and Wnt2 in the lung bud during early stages of organogenesis, as well as decreased tracheal expression of ..
  28. Pogach M, Cao Y, Millien G, Ramirez M, Williams M. Key developmental regulators change during hyperoxia-induced injury and recovery in adult mouse lung. J Cell Biochem. 2007;100:1415-29 pubmed
    ..the following genes based upon their known or putative roles in lung development and organogenesis: TTF-1, FGF9, FGF10, BMP4, PDGF-A, VEGF, Ptc, Shh, Sca-1, BCRP, CD45, and Cyclin-D2...
  29. Kwon H, Park E, Jia S, Liu H, Lan Y, Jiang R. Deletion of Osr2 Partially Rescues Tooth Development in Runx2 Mutant Mice. J Dent Res. 2015;94:1113-9 pubmed publisher
    ..molar morphogenesis, the Osr2(-/-)Runx2(-/-) compound mutant embryos failed to activate the expression of Fgf3 and Fgf10 in the dental papilla and exhibited significant deficit in cell proliferation in both the dental epithelium and ..
  30. Gomes J, Kowalski T, Fraga L, Tovo Rodrigues L, Sanseverino M, Schuler Faccini L, et al. Genetic susceptibility to thalidomide embryopathy in humans: Study of candidate development genes. Birth Defects Res. 2017;: pubmed publisher
    ..In this study, seven polymorphisms in genes related to development (FGF8, FGF10, BMP4, SHH, TP53, TP63, and TP73) were analyzed in people with thalidomide embryopathy (TE) and compared to people ..
  31. Hegab A, Ozaki M, Kagawa S, Hamamoto J, Yasuda H, Naoki K, et al. Tumor associated macrophages support the growth of FGF9-induced lung adenocarcinoma by multiple mechanisms. Lung Cancer. 2018;119:25-35 pubmed publisher
    ..TAMs had high expression of Tgf-β, Vegf, Fgf2, Fgf10, Fgfr2 and several matrix metalloproteinases; factors that play multiple roles in supporting tumor growth, immune ..
  32. Quantius J, Schmoldt C, Vazquez Armendariz A, Becker C, El Agha E, Wilhelm J, et al. Influenza Virus Infects Epithelial Stem/Progenitor Cells of the Distal Lung: Impact on Fgfr2b-Driven Epithelial Repair. PLoS Pathog. 2016;12:e1005544 pubmed publisher
    ..Intratracheal application of exogenous Fgf10, however, resulted in increased engagement of non-infected EpiSPC for tissue regeneration, demonstrated by ..
  33. Yamakawa H, Muraoka N, Miyamoto K, Sadahiro T, Isomi M, Haginiwa S, et al. Fibroblast Growth Factors and Vascular Endothelial Growth Factor Promote Cardiac Reprogramming under Defined Conditions. Stem Cell Reports. 2015;5:1128-1142 pubmed publisher
    ..Here, we report that a combination of fibroblast growth factor (FGF) 2, FGF10, and vascular endothelial growth factor (VEGF), termed FFV, promoted cardiac reprogramming under defined serum-..
  34. Upadhyay D, Bundesmann M, Panduri V, Correa Meyer E, Kamp D. Fibroblast growth factor-10 attenuates H2O2-induced alveolar epithelial cell DNA damage: role of MAPK activation and DNA repair. Am J Respir Cell Mol Biol. 2004;31:107-13 pubmed
    ..We conclude that FGF-10 attenuates H2O2-induced AEC DNA damage by mechanisms that involve activation of Grb2-SOS/Ras/RAF-1/ERK1/2 pathway and DNA repair. ..
  35. Itoh N. FGF10: A multifunctional mesenchymal-epithelial signaling growth factor in development, health, and disease. Cytokine Growth Factor Rev. 2016;28:63-9 pubmed publisher
    The FGF family comprises 22 members with diverse functions in development and health. FGF10 specifically activates FGFR2b in a paracrine manner with heparan sulfate as a co-factor...
  36. Eiró N, Fernandez Gomez J, Sacristan R, Fernandez Garcia B, Lobo B, Gonzalez Suarez J, et al. Stromal factors involved in human prostate cancer development, progression and castration resistance. J Cancer Res Clin Oncol. 2017;143:351-359 pubmed publisher
    ..genomic expression of 20 stroma-derived factors, including the androgen receptor (AR), growth factors (FGF2, FGF7, FGF10, HGF, TGF?, PDGFB), protein implicated in invasion (MMP-2, MMP-9 and MMP-11), inflammation (IL-6, IL-17, STAT-3 ..
  37. Calderon Gierszal E, Prins G. Directed Differentiation of Human Embryonic Stem Cells into Prostate Organoids In Vitro and its Perturbation by Low-Dose Bisphenol A Exposure. PLoS ONE. 2015;10:e0133238 pubmed publisher
    ..Activin-induced definitive endoderm was driven to prostate specification by combined exposure to WNT10B and FGF10. Matrigel culture for 20-30 days in medium containing R-Spondin-1, Noggin, EGF, retinoic acid and testosterone was ..
  38. Ibrahimi O, Yeh B, Eliseenkova A, Zhang F, Olsen S, Igarashi M, et al. Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization. Mol Cell Biol. 2005;25:671-84 pubmed
    ..Taken together, the data validate the symmetric two-end model of FGFR dimerization and argue against the asymmetric model of FGFR dimerization. ..
  39. May A, Headon D, Rice D, Noble A, Tucker A. FGF and EDA pathways control initiation and branching of distinct subsets of developing nasal glands. Dev Biol. 2016;419:348-356 pubmed publisher
    ..imperative role of FGF signalling during the development of other branched structures, we investigated the role of Fgf10 during initiation and branching morphogenesis of murine nasal SMGs...
  40. Sathi G, Farahat M, Hara E, Taketa H, Nagatsuka H, Kuboki T, et al. MCSF orchestrates branching morphogenesis in developing submandibular gland tissue. J Cell Sci. 2017;130:1559-1569 pubmed publisher
    ..cells, as well as indirectly, by modulating the expression of major growth factors of SMG growth, FGF7 and FGF10, via the phosphoinositide 3-kinase (PI3K) pathway...
  41. Chen J, Wang Z, Zheng Z, Chen Y, Khor S, Shi K, et al. Neuron and microglia/macrophage-derived FGF10 activate neuronal FGFR2/PI3K/Akt signaling and inhibit microglia/macrophages TLR4/NF-?B-dependent neuroinflammation to improve functional recovery after spinal cord injury. Cell Death Dis. 2017;8:e3090 pubmed publisher
    ..Previous studies have shown that neuron-derived FGF10 exerts potential neuroprotective effects after cerebral ischemia injury...
  42. Carpenter G, Ji Q. Phospholipase C-gamma as a signal-transducing element. Exp Cell Res. 1999;253:15-24 pubmed
    ..However, the biochemistry of PLC-gamma is at a more advanced state than a clear understanding of exactly how this signaling element functions in the generation of a mitogenic response. ..
  43. Li Y, Yang L, Chen W, Li Y, Yuan H. Fibroblast growth factor 10 protects neuron against oxygen-glucose deprivation injury through inducing heme oxygenase-1. Biochem Biophys Res Commun. 2015;456:225-31 pubmed publisher
    ..Here, we investigated the potential effect of FGF10, a member of FGFs, on neuron survival in oxygen-glucose deprivation (OGD) model...
  44. Ferreira R, Chiaratti M, Macabelli C, Rodrigues C, Ferraz M, Watanabe Y, et al. The Infertility of Repeat-Breeder Cows During Summer Is Associated with Decreased Mitochondrial DNA and Increased Expression of Mitochondrial and Apoptotic Genes in Oocytes. Biol Reprod. 2016;94:66 pubmed publisher
    ..NRF1, POLG, POLG2, PPARGC1A, and TFAM), apoptosis (BAX, BCL2, and ITM2B), and oocyte maturation (BMP15, FGF8, FGF10, FGF16, FGF17, and GDF9)...
  45. Alibardi L. Immunolocalization of FGF8/10 in the Apical Epidermal Peg and Blastema of the regenerating tail in lizard marks this apical growing area. Ann Anat. 2016;206:14-20 pubmed publisher
    ..The present study is focused on the immunolocalization of FGF8 and FGF10 in the regenerating lizard tail, two signaling proteins of the apical epidermal cup/ridge and mesenchymal blastema ..
  46. Dooley J, Erickson M, Larochelle W, Gillard G, Farr A. FGFR2IIIb signaling regulates thymic epithelial differentiation. Dev Dyn. 2007;236:3459-71 pubmed
    ..we show that targeted expression by thymocytes of an fibroblast growth factor receptor-2IIIb (FGFR2IIIb) ligand, FGF10, profoundly alters the differentiation and function of thymic epithelium (TE)...
  47. Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, et al. Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10. Mol Cell Biol. 2014;34:2848-56 pubmed publisher
    ..as a side population and quiescent (G0) cell cycle fraction in human lung cancer cells by virtue of fibroblast growth factor 10 (FGF10)...
  48. Jiang J, Zhong C, Zhu Y, Xu D, Wood K, Sun W, et al. Prenatal exposure to di-n-butyl phthalate (DBP) differentially alters androgen cascade in undeformed versus hypospadiac male rat offspring. Reprod Toxicol. 2016;61:75-81 pubmed publisher
    ..androgen synthetic pathway in the testes, and ablated genes of developmental pathways, such as Shh, Bmp4, Fgf8, Fgf10 and Fgfr2, in the genital tubercle (GT) as compared to those in DBP-unexposed controls, albeit hypospadiac rats ..
  49. Terakawa J, Rocchi A, Serna V, Bottinger E, Graff J, Kurita T. FGFR2IIIb-MAPK Activity Is Required for Epithelial Cell Fate Decision in the Lower Müllerian Duct. Mol Endocrinol. 2016;30:783-95 pubmed publisher
    ..In the developing reproductive tract, FGF7 and FGF10 were enriched in vaginal mesenchyme, whereas FGF receptor 2IIIb was expressed in epithelia of both the uterus and ..
  50. McGaugh E, Nostro M. Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors. J Vis Exp. 2017;: pubmed publisher
    ..Further differentiation and patterning with Fibroblast Growth Factor 10 (FGF10) and Dorsomorphin generates cells resembling the posterior foregut...
  51. Li S, Christensen C, Kiselyov V, Køhler L, Bock E, Berezin V. Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor. J Neurochem. 2008;104:667-82 pubmed publisher
    ..Some, but not all, dekafins were capable of promoting survival of cerebellar granule neurons induced to undergo apoptosis. Thus, the dekafins are functional FGFR agonists with apparent therapeutic potential. ..
  52. Yamada A, Futagi M, Fukumoto E, Saito K, Yoshizaki K, Ishikawa M, et al. Connexin 43 Is Necessary for Salivary Gland Branching Morphogenesis and FGF10-induced ERK1/2 Phosphorylation. J Biol Chem. 2016;291:904-12 pubmed publisher
    ..The expression of Pdgfa, Pdgfb, Fgf7, and Fgf10, which induced branching of SMGs in Cx43(-/-) samples, were not changed as compared with those from heterozygotes...
  53. Li Y, Fu H, Tian M, Wang Y, Chen W, Cai L, et al. Neuron-derived FGF10 ameliorates cerebral ischemia injury via inhibiting NF-κB-dependent neuroinflammation and activating PI3K/Akt survival signaling pathway in mice. Sci Rep. 2016;6:19869 pubmed publisher
    b>FGF10 is a member of fibroblast growth factors (FGFs). We previously showed that FGF10 protects neuron against oxygen-glucose deprivation injury in vitro; however, the effect of FGF10 in ischemic stroke in vivo is unknown...
  54. Chen C, Ng C, Wu S, Chen J, Cheng P, Wu P, et al. Regulatory Differences in Natal Down Development between Altricial Zebra Finch and Precocial Chicken. Mol Biol Evol. 2016;33:2030-43 pubmed publisher
    ..of FGF16 on chicken leg skin showed downregulation of SHH, upregulation of the feather growth suppressor FGF10, and suppression of feather bud elongation, similar to the phenotype found in zebra finch embryonic AD skin...
  55. Teshima T, Lourenço S, Tucker A. Multiple Cranial Organ Defects after Conditionally Knocking Out Fgf10 in the Neural Crest. Front Physiol. 2016;7:488 pubmed
    i>Fgf10 is necessary for the development of a number of organs that fail to develop or are reduced in size in the null mutant. Here we have knocked out Fgf10 specifically in the neural crest driven by Wnt1cre...
  56. Cruz C, Mattos C, Maia J, Granjeiro J, Reis M, Mucha J, et al. Genetic polymorphisms underlying the skeletal Class III phenotype. Am J Orthod Dentofacial Orthop. 2017;151:700-707 pubmed publisher
    ..001) and GHR (rs2973015 A>G) (P = 0.001) with PC2 and between FGF10 (rs593307 A<G) (P = 0.001) with PC4...
  57. Leung M, Hutson M, Seifert A, Spencer R, Knudsen T. Computational modeling and simulation of genital tubercle development. Reprod Toxicol. 2016;64:151-61 pubmed publisher
    ..The prototype model, constructed in CompuCell3D, recapitulates key aspects of GT morphogenesis controlled by SHH, FGF10, and androgen pathways through modulation of stochastic cell behaviors, including differential adhesion, motility, ..
  58. Ho U, Wainwright B. Patched1 patterns Fibroblast growth factor 10 and Forkhead box F1 expression during pulmonary branch formation. Mech Dev. 2017;147:37-48 pubmed publisher
    Hedgehog (Hh) signalling, Fibroblast growth factor 10 (Fgf10) and Forkhead box F1 (Foxf1) are each individually important for directing pulmonary branch formation but their interactions are not well understood...
  59. Nishio K, Tanihara F, Nguyen T, Kunihara T, Nii M, Hirata M, et al. Effects of voltage strength during electroporation on the development and quality of in vitro-produced porcine embryos. Reprod Domest Anim. 2017;: pubmed publisher
    ..05). When zygotes were electroporated with Cas9 mRNA and single-guide RNA (sgRNA) targeting site in the FGF10 exon 3, the proportions of blastocysts with targeted genomic sequences were 7.7% (2/26) and 3...
  60. Lee E, Le T, Zhu Y, Elakis G, Turner A, Lo W, et al. A craniosynostosis massively parallel sequencing panel study in 309 Australian and New Zealand patients: findings and recommendations. Genet Med. 2018;20:1061-1068 pubmed publisher
    ..Clinically significant variants were also identified in ALX4, EFNA4, ERF, and FGF10. These findings support the clinical utility of a massively parallel sequencing panel for craniosynostosis...
  61. Jimenez P, Rampy M. Keratinocyte growth factor-2 accelerates wound healing in incisional wounds. J Surg Res. 1999;81:238-42 pubmed
    ..KGF-2 could be an important cellular mediator responsible for the initiation and acceleration of wound healing and may enhance the healing of surgical wounds. ..
  62. Ropiquet F, Giri D, Kwabi Addo B, Schmidt K, Ittmann M. FGF-10 is expressed at low levels in the human prostate. Prostate. 2000;44:334-8 pubmed
    ..Prior work has indicated that FGF10 may play an important role in the development of the rat prostate, but its role in the adult human prostate is ..
  63. Izvolsky K, Zhong L, Wei L, Yu Q, Nugent M, Cardoso W. Heparan sulfates expressed in the distal lung are required for Fgf10 binding to the epithelium and for airway branching. Am J Physiol Lung Cell Mol Physiol. 2003;285:L838-46 pubmed
    Fibroblast growth factor (Fgf) 10 is a critical regulator of bud formation during lung morphogenesis. fgf10 is expressed in distal lung mesenchyme at sites of prospective budding from the earliest developmental stages and signals through ..
  64. Theodorou V, Boer M, Weigelt B, Jonkers J, van der Valk M, Hilkens J. Fgf10 is an oncogene activated by MMTV insertional mutagenesis in mouse mammary tumors and overexpressed in a subset of human breast carcinomas. Oncogene. 2004;23:6047-55 pubmed
    ..in mammary tumors from BALB/c mice infected with C3H-MMTV, we have found a common MMTV insertion site in the Fgf10 locus...
  65. Beer H, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, et al. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair. Oncogene. 2005;24:5269-77 pubmed
  66. Zhang X, Ibrahimi O, Olsen S, Umemori H, Mohammadi M, Ornitz D. Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J Biol Chem. 2006;281:15694-700 pubmed
    ..This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity. ..
  67. Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, Torrisi M, et al. Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes. Exp Cell Res. 2007;313:1758-77 pubmed
    Keratinocyte growth factor (KGF/FGF7) and fibroblast growth factor 10 (FGF10/KGF2) regulate keratinocyte proliferation and differentiation by binding to the tyrosine kinase KGF receptor (KGFR)...
  68. Lendvay T, Sweet R, Han C, Soygur T, Cheng J, Plaire J, et al. Compensatory paracrine mechanisms that define the urothelial response to injury in partial bladder outlet obstruction. Am J Physiol Renal Physiol. 2007;293:F1147-56 pubmed
    ..In contrast, a significant increase in FGF-10 expression was observed in the obstructed FGF-7-null group, indicating that the compensatory pathway that functions in this model results in urothelial repair. ..
  69. Carev D, Saraga M, Saraga Babic M. Involvement of FGF and BMP family proteins and VEGF in early human kidney development. Histol Histopathol. 2008;23:853-62 pubmed publisher
    ..Due to VEGF involvement in vasculogenesis and angiogenesis, abnormal VEGF appearance might lead to impaired formation of the blood vessel network in the human permanent kidney. ..
  70. Laurin N, Wigg K, Feng Y, Sandor P, Barr C. Chromosome 5 and Gilles de la Tourette syndrome: Linkage in a large pedigree and association study of six candidates in the region. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:95-103 pubmed publisher
    ..These genes were GDNF, ITGA1, ISL1, FGF10, HCN1 and SLC1A3...
  71. Wang J, Cai X, Zou M, Wang Y, Wang J, Xu D. Thr-114 is an important functional residue of fibroblast growth factor 10 identified by structure-based mutational analysis. Cytokine. 2010;49:338-43 pubmed publisher
    b>Fibroblast growth factor 10 (FGF10) plays important roles in vertebrate limb development, lung branching morphogenesis, and epidermis regeneration...
  72. Yoshida M, Meguro A, Okada E, Nomura N, Mizuki N. Association study of fibroblast growth factor 10 (FGF10) polymorphisms with susceptibility to extreme myopia in a Japanese population. Mol Vis. 2013;19:2321-9 pubmed
    The fibroblast growth factor 10 (FGF10) gene polymorphism rs339501 was previously reported to be associated with high myopia in a Chinese population...
  73. Yeh E, Atique R, Fanganiello R, Sunaga D, Ishiy F, Passos Bueno M. Cell Type-Dependent Nonspecific Fibroblast Growth Factor Signaling in Apert Syndrome. Stem Cells Dev. 2016;25:1249-60 pubmed publisher
    ..We found that FGF19 and FGF10 increase proliferation of fibroblastoid cells harboring the FGFR2 p.S252W mutation, but not of mutant MSCs...
  74. Ghoussaini M, French J, Michailidou K, Nord S, Beesley J, Canisus S, et al. Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. Am J Hum Genet. 2016;99:903-911 pubmed publisher
    ..and breast tumors showed that the g (risk) allele of rs10941679 was associated with increased expression of FGF10 and MRPS30...
  75. Chatzeli L, Gaete M, Tucker A. Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development. Development. 2017;144:2294-2305 pubmed publisher
    ..We demonstrate that Sox9 is positively regulated by mesenchymal Fgf10, a process that requires active Erk signalling...
  76. Diógenes M, Guimarães A, Leme L, Maurício M, Dode M. Effect of prematuration and maturation with fibroblast growth factor 10 (FGF10) on in vitro development of bovine oocytes. Theriogenology. 2017;102:190-198 pubmed publisher
    In an attempt to improve in vitro embryo production, we investigated the effect of FGF10 and 0...
  77. Huang J, Lynn Miskus M, Lu H. FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation. J Neurosci. 2017;37:12094-12105 pubmed publisher
    ..vivo, within 6 h of systemic kainic acid administration at postnatal day 6, mRNA levels of Fgf9, Fgf10, Fgfr2c, and Fgfr3b in S1 cortices were enhanced, and this was accompanied by exuberant ..
  78. Danková Z, Zubor P, Grendar M, Kapinová A, Zelinova K, Jagelkova M, et al. Association of single nucleotide polymorphisms in FGF-RAS/MAP signalling cascade with breast cancer susceptibility. Gen Physiol Biophys. 2017;36:565-572 pubmed publisher
    ..This study aims to determine the association between FGF10 (rs4415084 C>T), FGFR2 (rs2981582 C>T) and MAP3K1 (rs889312 A>C) gene polymorphisms and breast cancer, to ..
  79. Graeff R, Wang G, McCray P. KGF and FGF-10 stimulate liquid secretion in human fetal lung. Pediatr Res. 1999;46:523-9 pubmed
    ..however, recent studies in murine models show that keratinocyte growth factor (KGF, FGF-7) and fibroblast growth factor 10 (FGF-10) stimulate liquid secretion...
  80. Robson M, Phillips T, Falanga V, Odenheimer D, Parish L, Jensen J, et al. Randomized trial of topically applied repifermin (recombinant human keratinocyte growth factor-2) to accelerate wound healing in venous ulcers. Wound Repair Regen. 2001;9:347-52 pubmed
    ..g., 26 weeks) may allow better differentiation of the benefit of repifermin compared with placebo, particularly with respect to complete wound closure. The safety assessment showed that repifermin was well tolerated. ..
  81. Beleza Meireles A, Lundberg F, Lagerstedt K, Zhou X, Omrani D, Frisén L, et al. FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. Eur J Hum Genet. 2007;15:405-10 pubmed
    ..In both Fgf10 and Fgfr2 deficient mutant hypospadic male mice, cell proliferation is arrested prematurely and the maturation of ..
  82. Belleudi F, Leone L, Nobili V, Raffa S, Francescangeli F, Maggio M, et al. Keratinocyte growth factor receptor ligands target the receptor to different intracellular pathways. Traffic. 2007;8:1854-72 pubmed
    ..interaction with two different ligands, keratinocyte growth factor (KGF)/fibroblast growth factor (FGF)7 and FGF10/KGF2, which are characterized by an opposite requirement of heparan sulfate proteoglycans and heparin for binding ..
  83. Patel V, Knox S, Likar K, Lathrop C, Hossain R, Eftekhari S, et al. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis. Development. 2007;134:4177-86 pubmed
    ..activity in organ culture decreased branching morphogenesis, and this inhibition was rescued specifically by FGF10 and not by other FGFs...
  84. Hajihosseini M, De Langhe S, Lana Elola E, Morrison H, Sparshott N, Kelly R, et al. Localization and fate of Fgf10-expressing cells in the adult mouse brain implicate Fgf10 in control of neurogenesis. Mol Cell Neurosci. 2008;37:857-68 pubmed publisher
    We used Fgf10-lacZ reporter mice to investigate the distribution and fate of Fgf10-expressing cells in the developing and adult mouse brain...
  85. Zhang X, Wu M, Zhang W, Shen J, Liu H. Differentiation of human adipose-derived stem cells induced by recombinantly expressed fibroblast growth factor 10 in vitro and in vivo. In Vitro Cell Dev Biol Anim. 2010;46:60-71 pubmed publisher
    The adipogenesis effect of fibroblast growth factor 10 (FGF10) has been demonstrated in many studies...
  86. Nyeng P, Bjerke M, Norgaard G, Qu X, Kobberup S, Jensen J. Fibroblast growth factor 10 represses premature cell differentiation during establishment of the intestinal progenitor niche. Dev Biol. 2011;349:20-34 pubmed publisher
    ..In order to elucidate these questions we performed a complementary analysis of fibroblast growth factor 10 (Fgf10), gain-of-function and loss-of-function in the embryonic mouse duodenum, where the progenitor ..
  87. Browne M, Carter T, Kay D, Kuehn D, Brody L, Romitti P, et al. Evaluation of genes involved in limb development, angiogenesis, and coagulation as risk factors for congenital limb deficiencies. Am J Med Genet A. 2012;158A:2463-72 pubmed publisher
    ..Genotypes were obtained for 132 SNPs in genes involved in limb development (SHH, WNT7A, FGF4, FGF8, FGF10, TBX3, TBX5, SALL4, GREM1, GDF5, CTNNB1, EN1, CYP26A1, CYP26B1), angiogenesis (VEGFA, HIF1A, NOS3), and ..
  88. Yin S, Tang X, Li F, Zhang T, Yuan Z, Wang W, et al. Spatiotemporal expression of fibroblast growth factor 10 in human hindgut and anorectal development. Cells Tissues Organs. 2013;198:28-34 pubmed publisher
    As fibroblast growth factor 10 (FGF-10) gene expression may have a role in anorectal duct formation, this study aimed to assess the spatiotemporal expression pattern of FGF-10 during development of the rectum and hindgut in human embryos...
  89. Nakao Y, Mitsuyasu T, Kawano S, Nakamura N, Kanda S, Nakamura S. Fibroblast growth factors 7 and 10 are involved in ameloblastoma proliferation via the mitogen-activated protein kinase pathway. Int J Oncol. 2013;43:1377-84 pubmed publisher
    ..Fibroblast growth factor (FGF) 3, FGF7 and FGF10, which are expressed by the neural crest-derived ectomesenchymal cells, induce the proliferation of odontogenic ..
  90. Sugimoto K, Yoshida S, Mashio Y, Toyota N, Xing Y, Xu H, et al. Role of FGF10 on tumorigenesis by MS-K. Genes Cells. 2014;19:112-25 pubmed publisher
    ..Taken together, these results indicated that FGF10, which was produced from tumor cells, was essential for the proliferation of tumor cell itself and also supports ..
  91. Sun Q, Lin P, Zhang J, Li X, Yang L, Huang J, et al. Expression of Fibroblast Growth Factor 10 Is Correlated with Poor Prognosis in Gastric Adenocarcinoma. Tohoku J Exp Med. 2015;236:311-8 pubmed publisher
    ..As a specific ligand to FGFR2-IIIb, fibroblast growth factor 10 (FGF10) is expressed in the gastric mesenchyme cell and is involved in stomach development and ..
  92. Garg A, Bansal M, Gotoh N, Feng G, Zhong J, Wang F, et al. Alx4 relays sequential FGF signaling to induce lacrimal gland morphogenesis. PLoS Genet. 2017;13:e1007047 pubmed publisher
    ..crests, Shp2 is also required for expression of the homeodomain transcription factor Alx4, which directly controls Fgf10 expression in the periocular mesenchyme that is necessary for lacrimal gland induction...