FGF1

Summary

Gene Symbol: FGF1
Description: fibroblast growth factor 1
Alias: AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1, fibroblast growth factor 1, beta-endothelial cell growth factor, endothelial cell growth factor, alpha, endothelial cell growth factor, beta, fibroblast growth factor 1 (acidic), heparin-binding growth factor 1
Species: human
Products:     FGF1

Top Publications

  1. Kang S, Li S, Wang N, Zhou R, Wang T, Wang D, et al. Association between genetic polymorphisms in fibroblast growth factor (FGF)1 and FGF2 and risk of endometriosis and adenomyosis in Chinese women. Hum Reprod. 2010;25:1806-11 pubmed publisher
    ..We investigated whether FGF1 -1385A/G and FGF2 754C/G polymorphisms are associated with a risk of developing EM and adenomyosis...
  2. Zhu X, Komiya H, Chirino A, Faham S, Fox G, Arakawa T, et al. Three-dimensional structures of acidic and basic fibroblast growth factors. Science. 1991;251:90-3 pubmed
    ..These sites include beta-sheet strand 10, which is adjacent to the site of an extended sequence insertion in several oncogene proteins of the FGF family, and which shows sequence conservation among the FGF family and interleukin-1 beta. ..
  3. Ornitz D, Xu J, Colvin J, McEwen D, MacArthur C, Coulier F, et al. Receptor specificity of the fibroblast growth factor family. J Biol Chem. 1996;271:15292-7 pubmed
    ..These studies demonstrate that FGF 1 is the only FGF that can activate all FGF receptor splice variants...
  4. Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes P, Olsnes S. Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor. Biochem J. 1998;336 ( Pt 1):213-22 pubmed
    In addition to its extracellular action, there is evidence that acidic fibroblast growth factor (aFGF) acts inside cells...
  5. Mizukoshi E, Suzuki M, Loupatov A, Uruno T, Hayashi H, Misono T, et al. Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin. Biochem J. 1999;343 Pt 2:461-6 pubmed
    ..These results reveal that GRP75/mortalin is an intracellular FGF-1-binding protein in cells and suggest that GRP75/mortalin is involved in the trafficking of and/or signalling by FGF-1. ..
  6. Plotnikov A, Hubbard S, Schlessinger J, Mohammadi M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell. 2000;101:413-24 pubmed
    ..governing specificity in fibroblast growth factor (FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor ..
  7. Schlessinger J, Plotnikov A, Ibrahimi O, Eliseenkova A, Yeh B, Yayon A, et al. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 2000;6:743-50 pubmed
    ..This model provides a structural basis for FGFR activation by small molecule heparin analogs and may facilitate the design of heparin mimetics capable of modulating FGF signaling. ..
  8. Skjerpen C, Wesche J, Olsnes S. Identification of ribosome-binding protein p34 as an intracellular protein that binds acidic fibroblast growth factor. J Biol Chem. 2002;277:23864-71 pubmed
    With the aim of identifying new intracellular binding partners for acidic fibroblast growth factor (aFGF), proteins from U2OS human osteosarcoma cells were adsorbed to immobilized aFGF...
  9. Brych S, Kim J, Logan T, Blaber M. Accommodation of a highly symmetric core within a symmetric protein superfold. Protein Sci. 2003;12:2704-18 pubmed
    ..Remaining asymmetry within the core appears to be related to asymmetry in the tertiary structure associated with receptor and heparin binding functionality of the growth factor. ..

More Information

Publications108 found, 100 shown here

  1. Wesche J, Małecki J, Wiedłocha A, Ehsani M, Marcinkowska E, Nilsen T, et al. Two nuclear localization signals required for transport from the cytosol to the nucleus of externally added FGF-1 translocated into cells. Biochemistry. 2005;44:6071-80 pubmed
    ..Stimulation of DNA synthesis by FGF-1 with mutations in both NLSs was reduced considerably indicating that efficient transport to the nucleus may be involved in the stimulation of DNA synthesis. ..
  2. Zhen Y, Sørensen V, Skjerpen C, Haugsten E, Jin Y, Walchli S, et al. Nuclear import of exogenous FGF1 requires the ER-protein LRRC59 and the importins Kpn?1 and Kpn?1. Traffic. 2012;13:650-64 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1) taken up by cells into endocytic vesicles can be translocated across vesicular membranes into the cytosol and the nucleus where it has a growth regulatory activity...
  3. Slattery M, John E, Stern M, Herrick J, Lundgreen A, Giuliano A, et al. Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2013;140:587-601 pubmed publisher
    ..in epidermal growth factor (EGF), neuregulin 2 (NRG2), ERBB2 (HER2/neu), fibroblast growth factors 1 and 2 (FGF1 and FGF2) and its receptor 2 (FGFR2), and platelet-derived growth factor B (PDGFB) independently and collectively ..
  4. Gimenez Gallego G, Conn G, Hatcher V, Thomas K. The complete amino acid sequence of human brain-derived acidic fibroblast growth factor. Biochem Biophys Res Commun. 1986;138:611-7 pubmed
    ..A potential Asn-Gly-Ser glycosylation sequence is present in the human protein. The complete amino acid sequence is compared to that of the equivalent protein purified from bovine brain. ..
  5. Myers R, Payson R, Chotani M, Deaven L, Chiu I. Gene structure and differential expression of acidic fibroblast growth factor mRNA: identification and distribution of four different transcripts. Oncogene. 1993;8:341-9 pubmed
    We have isolated four cDNA clones coding for human acidic fibroblast growth factor (aFGF) containing alternative 5' untranslated exons...
  6. Payson R, Canatan H, Chotani M, Wang W, Harris S, Myers R, et al. Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNA. Nucleic Acids Res. 1993;21:489-95 pubmed
    We have previously isolated two different aFGF cDNA clones from kidney and brain. The two corresponding mRNA, designated aFGF 1.A and 1.B, are the predominant species in kidney and brain, respectively...
  7. Blaber M, DiSalvo J, Thomas K. X-ray crystal structure of human acidic fibroblast growth factor. Biochemistry. 1996;35:2086-94 pubmed
    ..We report here the X-ray crystal structure of human acidic FGF (aFGF), with data extending to 2.0 angstroms resolution...
  8. DiGabriele A, Lax I, Chen D, Svahn C, Jaye M, Schlessinger J, et al. Structure of a heparin-linked biologically active dimer of fibroblast growth factor. Nature. 1998;393:812-7 pubmed
    ..The dimerization of heparin-linked acidic FGF observed here is an elegant mechanism for the modulation of signalling through combinatorial homodimerization and heterodimerization of the 12 known members of the FGF family. ..
  9. Pellegrini L, Burke D, von Delft F, Mulloy B, Blundell T. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature. 2000;407:1029-34 pubmed
    ..report the crystal structure of the FGFR2 ectodomain in a dimeric form that is induced by simultaneous binding to FGF1 and a heparin decasaccharide...
  10. Skjerpen C, Nilsen T, Wesche J, Olsnes S. Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity. EMBO J. 2002;21:4058-69 pubmed
    ..A correlation between the mitogenic potential of FGF-1 mutants and their ability to bind to CK2 alpha was observed. The possible involvement of CK2 in the FGF-induced stimulation of DNA synthesis is discussed. ..
  11. Yoneyama T, Kasuya H, Onda H, Akagawa H, Jinnai N, Nakajima T, et al. Association of positional and functional candidate genes FGF1, FBN2, and LOX on 5q31 with intracranial aneurysm. J Hum Genet. 2003;48:309-14 pubmed
    ..In the present study, we focus on 5q31, where three candidate genes, fibroblast growth factor 1 (FGF1), fibrillin 2 (FBN2), and lysyl oxidase gene ( LOX) lie, and evaluate associations with IA...
  12. Vargas M, Pehar M, Cassina P, Martinez Palma L, Thompson J, Beckman J, et al. Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. J Biol Chem. 2005;280:25571-9 pubmed
    ..Taken together, these results emphasize the key role of astrocytes in determining motor neuron fate in amyotrophic lateral sclerosis. ..
  13. Dubey V, Lee J, Somasundaram T, Blaber S, Blaber M. Spackling the crack: stabilizing human fibroblast growth factor-1 by targeting the N and C terminus beta-strand interactions. J Mol Biol. 2007;371:256-68 pubmed
    ..Such stabilized mutations of FGF-1 are shown to exhibit significant increases in effective mitogenic potency, and may prove useful as "second generation" forms of FGF-1 for application in angiogenic therapy. ..
  14. Mori S, Wu C, Yamaji S, Saegusa J, Shi B, Ma Z, et al. Direct binding of integrin alphavbeta3 to FGF1 plays a role in FGF1 signaling. J Biol Chem. 2008;283:18066-75 pubmed publisher
    ..We discovered that FGF1 directly bound to soluble and cell-surface integrin alphavbeta3 (K(D) about 1 microm)...
  15. Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov. 2009;8:235-53 pubmed publisher
  16. Zakrzewska M, Wiedlocha A, Szlachcic A, Krowarsch D, Otlewski J, Olsnes S. Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. J Biol Chem. 2009;284:25388-403 pubmed publisher
    Human FGF1 (fibroblast growth factor 1) is a powerful signaling molecule with a short half-life in vivo and a denaturation temperature close to physiological...
  17. Kameyama H, Udagawa O, Hoshi T, Toukairin Y, Arai T, Nogami M. The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds. Leg Med (Tokyo). 2015;17:255-60 pubmed publisher
    ..C-X-C motif) ligand 2 (CXCL2), chemokine (C-X-C motif) ligand12 (CXCL12/SDF1), endothelin 1 (ET1), fibroblast growth factor 1 (FGF 1), hepatocyte growth factor (HGF), hypoxia inducible factor 1 alpha (HIF1a), leptin, matrix ..
  18. Hu P, Chen H, McGowan E, Ren N, Xu M, Lin Y. Assessment of FGFR1 Overexpression and Over-Activity in Lung Cancer Cells: A Toolkit for Anti-FGFR1 Drug Screening. Hum Gene Ther Methods. 2017;: pubmed publisher
    ..Importantly, this model provides an effective and simple screening kit for anti-FGF1 drug compounds for lung cancer treatment and a tool for understanding the molecular mechanisms of the FGFR1 ..
  19. Haugsten E, Sørensen V, Kunova Bosakova M, de Souza G, Krejci P, Wiedlocha A, et al. Proximity Labeling Reveals Molecular Determinants of FGFR4 Endosomal Transport. J Proteome Res. 2016;15:3841-3855 pubmed
    ..291 proteins, including 80 proteins that were enriched in samples where the receptor was activated by the ligand (FGF1), among them several proteins previously found to be involved in FGFR signaling (e.g...
  20. Abdrabouh A. Liver disorders related to exposure to gasoline fumes in male rats and role of fenugreek seed supplementation. Environ Sci Pollut Res Int. 2019;26:8949-8957 pubmed publisher
    ..were significantly elevated with fibrotic markers, transforming growth factor (TGFβ1), fibroblast growth factor (FGF1), and collagen I...
  21. Garimella R, Tadikonda P, Tawfik O, Gunewardena S, Rowe P, Van Veldhuizen P. Vitamin D Impacts the Expression of Runx2 Target Genes and Modulates Inflammation, Oxidative Stress and Membrane Vesicle Biogenesis Gene Networks in 143B Osteosarcoma Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..pathway analysis revealed significant reduction in Runx2 target genes such as fibroblast growth factor -1, -12 (FGF1 and FGF12), bone morphogenetic factor-1 (BMP1), SWI/SNF related, matrix associated actin ..
  22. Kim S, Eun J, Cho H, Lee H, Seo C, Noh C, et al. Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma. Anticancer Res. 2019;39:2217-2226 pubmed publisher
    ..We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and c-MET genes in 245 HCC patients and 483 chronic hepatitis B virus (HBV) ..
  23. Lange A, Jaskula E, Lange J, Dworacki G, Nowak D, Simiczyjew A, et al. The sorafenib anti-relapse effect after alloHSCT is associated with heightened alloreactivity and accumulation of CD8+PD-1+ (CD279+) lymphocytes in marrow. PLoS ONE. 2018;13:e0190525 pubmed publisher
    ..4 (ANGPTL4) (supporting the immune response and anti-angiogenic) genes, and (ii) higher expression of fibroblast growth factor 1 (FGF1) and collagen type IV alpha 3 chain (COL4A3) as well as toll like receptor 9 (TLR9) and ..
  24. Higginson J, Thompson S, Santos Silva A, Guimond S, Turnbull J, Barnett S. Differential sulfation remodelling of heparan sulfate by extracellular 6-O-sulfatases regulates fibroblast growth factor-induced boundary formation by glial cells: implications for glial cell transplantation. J Neurosci. 2012;32:15902-12 pubmed publisher
    ..Furthermore, specific anti-FGF1 and anti-FGF9 antibodies disrupted SC-astrocyte boundary formation, supporting a role for an HS sulfation-dependent ..
  25. Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, et al. HIF-1? in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance. Diabetes. 2016;65:3649-3659 pubmed
    ..endothelial cells of HIF-1?-deficient mice expressed higher levels of angiogenic factors, including Vegfa, Angpt1, Fgf1, and Fgf10 in accordance with preferable eWAT remodeling...
  26. Kostas M, Haugsten E, Zhen Y, Sørensen V, Szybowska P, Fiorito E, et al. Protein Tyrosine Phosphatase Receptor Type G (PTPRG) Controls Fibroblast Growth Factor Receptor (FGFR) 1 Activity and Influences Sensitivity to FGFR Kinase Inhibitors. Mol Cell Proteomics. 2018;17:850-870 pubmed publisher
    ..osteosarcoma cell lines depleted for PTPRG display increased FGFR activity and are hypersensitive to stimulation by FGF1. In addition, PTPRG depletion elevated cell growth and negatively affected the efficacy of FGFR kinase inhibitors...
  27. Tawiah A, Moreau F, Kumar M, Tiwari S, Falguera J, Chadee K. High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors. Am J Pathol. 2018;188:2025-2041 pubmed publisher
    ..We conclude that high MUC2 output during colitis impairs goblet cell migration and wound healing by reducing production of growth factors critical in wound repair. ..
  28. Braga M, Simmons Z, Norris K, Ferrini M, Artaza J. Vitamin D induces myogenic differentiation in skeletal muscle derived stem cells. Endocr Connect. 2017;6:139-150 pubmed publisher
    ..of: (i) MYOD, (ii) MYOG, (iii) MYC2, (iv) skeletal muscle fast troponin I and T, (v) MYH1, (vi) IGF1 and 2, (vii) FGF1 and 2, (viii) BMP4, (ix) MMP9 and (x) FST. It also promotes myotube formation and decreases the expression of MSTN...
  29. Sarabipour S, Hristova K. Mechanism of FGF receptor dimerization and activation. Nat Commun. 2016;7:10262 pubmed publisher
    ..The observed effects due to the ligands fgf1 and fgf2 are very different...
  30. Udayakumar T, Nagle R, Bowden G. Fibroblast growth factor-1 transcriptionally induces membrane type-1 matrix metalloproteinase expression in prostate carcinoma cell line. Prostate. 2004;58:66-75 pubmed
    ..Our findings support the idea that paracrine and autocrine factors play an important role in the regulation of MT1-MMP in human prostate carcinoma cells. ..
  31. Lee J, Blaber M. Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine. J Mol Biol. 2009;393:128-39 pubmed publisher
    ..Thus, while the conserved free cysteine at position 83 in the majority of the FGF proteins may have a principal role in limiting functional half-life, evidence suggests that it is a vestigial half-cystine. ..
  32. Chen M, Lin H, Chiu H, Lee D, Chung Y, Chiu I. Human FGF1 promoter is active in ependymal cells and dopaminergic neurons in the brains of F1B-GFP transgenic mice. Dev Neurobiol. 2015;75:232-48 pubmed publisher
    b>FGF1 is involved in multiple biological functions and exhibits the importance in neuroprotective effects. Our previous studies indicated that, in human brain and retina, the FGF1B promoter controlled the expression of FGF1...
  33. Gimenez Gallego G, Conn G, Hatcher V, Thomas K. Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities. Biochem Biophys Res Commun. 1986;135:541-8 pubmed
  34. Mouta Carreira C, Lavallee T, Tarantini F, Jackson A, Lathrop J, Hampton B, et al. S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. J Biol Chem. 1998;273:22224-31 pubmed
  35. Fukushima S, Kato S, Maeda M, Shigemori M. Caspase-9 pathway activation by inhibiting endogenous fibroblast growth factor signaling in human glioma cells. Int J Oncol. 2008;32:467-73 pubmed
    ..The suppression of this or other specific anti-apoptotic pathways may lead to genetic or pharmacological manipulations that favorably modulate the malignant behavior of human gliomas. ..
  36. Wolf I, Levanon Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, et al. Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene. 2008;27:7094-105 pubmed publisher
    ..These data suggest klotho as a potential tumor suppressor and identify it as an inhibitor of the IGF-1 pathway and activator of the FGF pathway in human breast cancer. ..
  37. Du W, Prochazka J, Prochazkova M, Klein O. Expression of FGFs during early mouse tongue development. Gene Expr Patterns. 2016;20:81-7 pubmed publisher
    ..Fgf10, Fgf13, Fgf15, Fgf16 and Fgf18 could all be detected with various intensities in the mesenchyme, whereas Fgf1 and Fgf2 were expressed in both the epithelium and the mesenchyme...
  38. Hsu Y, Kao C, Chung Y, Lee D, Liu J, Chiu I. Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells. Exp Cell Res. 2016;344:153-66 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1) binds and activates FGF receptors, thereby regulating cell proliferation and neurogenesis...
  39. Borchel A, Verleih M, Rebl A, Goldammer T. Identification of genes involved in cold-shock response in rainbow trout (Oncorhynchus mykiss). J Genet. 2017;96:701-706 pubmed
    ..Instead of classical genes involved in temperature shock, the three genes encoding fibroblast growth factor 1 (fgf1), growth arrest and DNA-damageinducible, alpha (gadd45a) and sclerostin domain-containing protein ..
  40. Olsen S, Ibrahimi O, Raucci A, Zhang F, Eliseenkova A, Yayon A, et al. Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Proc Natl Acad Sci U S A. 2004;101:935-40 pubmed
    ..Here, we report the crystal structure of the three-Ig form of FGFR3c in complex with FGF1, an FGF that binds promiscuously to each of the seven principal FGFRs...
  41. Lin W, Chen C, Chang Y, Chen S, Chiu I, Chen L. SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway. Cell Signal. 2009;21:1060-72 pubmed publisher
    ..In this study, we showed that overexpressing a signaling adaptor protein, SH2B1beta, enhanced FGF1-induced neurite outgrowth in PC12 cells...
  42. Cao R, Yan B, Yang H, Zu X, Wen G, Zhong J. Effect of human S100A13 gene silencing on FGF-1 transportation in human endothelial cells. J Formos Med Assoc. 2010;109:632-40 pubmed publisher
    ..In this study, experiments were designed to determine the direct role of S100A13 in FGF-1 protein release and transportation...
  43. Wu L, Leijten J, van Blitterswijk C, Karperien M. Fibroblast growth factor-1 is a mesenchymal stromal cell-secreted factor stimulating proliferation of osteoarthritic chondrocytes in co-culture. Stem Cells Dev. 2013;22:2356-67 pubmed publisher
    ..We demonstrate that MSCs increase FGF-1 secretion on co-culture with hPCs, which, in turn, is responsible for increased hPCs proliferation in pellet co-cultures. ..
  44. Mori S, Kodaira M, Ito A, Okazaki M, Kawaguchi N, Hamada Y, et al. Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells. PLoS ONE. 2015;10:e0137486 pubmed publisher
    ..We previously reported that FGF1 directly binds to integrin αvβ3 and the interaction was required for FGF1 functions such as cell ..
  45. Simann M, Le Blanc S, Schneider V, Zehe V, Lüdemann M, Schütze N, et al. Canonical FGFs Prevent Osteogenic Lineage Commitment and Differentiation of Human Bone Marrow Stromal Cells Via ERK1/2 Signaling. J Cell Biochem. 2017;118:263-275 pubmed publisher
    ..Previously, Fibroblast Growth Factor 1 (FGF1) and its subfamily member FGF2 were scored as leading candidates to exercise control over skeletal ..
  46. Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh B, et al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997;276:955-60 pubmed
    ..This structural information will facilitate the design of new inhibitors for use in the treatment of cancer and other diseases in which cell signaling by tyrosine kinases plays a crucial role in disease pathogenesis. ..
  47. Jung J, Zheng M, Goldfarb M, Zaret K. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science. 1999;284:1998-2003 pubmed
    ..Treatment of isolated foregut endoderm from mouse embryos with FGF1 or FGF2, but not FGF8, was sufficient to replace cardiac mesoderm as an inducer of the liver gene expression ..
  48. Sahni A, Altland O, Francis C. FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth. J Thromb Haemost. 2003;1:1304-10 pubmed
    ..Fibrin may serve as a matrix reservoir for FGF-2 to support cell growth at sites of injury or thrombosis. ..
  49. Bernett M, Somasundaram T, Blaber M. An atomic resolution structure for human fibroblast growth factor 1. Proteins. 2004;57:626-34 pubmed
    A 1.10-A atomic resolution X-ray structure of human fibroblast growth factor 1 (FGF-1), a member of the beta-trefoil superfold, has been determined...
  50. Birrer M, Johnson M, Hao K, Wong K, Park D, Bell A, et al. Whole genome oligonucleotide-based array comparative genomic hybridization analysis identified fibroblast growth factor 1 as a prognostic marker for advanced-stage serous ovarian adenocarcinomas. J Clin Oncol. 2007;25:2281-7 pubmed
    ..3, exhibited the strongest correlation with overall survival (P < .01). From the 5q31 region, fibroblast growth factor 1 (FGF-1) was selected for further validation study...
  51. Uchida S, Shumyatsky G. Epigenetic regulation of Fgf1 transcription by CRTC1 and memory enhancement. Brain Res Bull. 2018;141:3-12 pubmed publisher
    ..More specifically, we focus on learning-strength-dependent changes in chromatin on the fibroblast growth factor 1 (Fgf1) gene and on the molecular events that modulate regulation of Fgf1 transcription, required for ..
  52. Chellaiah A, Yuan W, Chellaiah M, Ornitz D. Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity. J Biol Chem. 1999;274:34785-94 pubmed
    ..These data demonstrate that multiple regions of the FGFR regulate ligand binding specificity and that these regions are distinct with respect to different members of the FGF family. ..
  53. Landriscina M, Bagala C, Mandinova A, Soldi R, Micucci I, Bellum S, et al. Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. J Biol Chem. 2001;276:25549-57 pubmed
    ..Since FGF1 is a Cu2+-binding protein and Cu2+ is known to induce its dimerization, we evaluated the capacity of recombinant ..
  54. Lee J, Dubey V, Longo L, Blaber M. A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J Mol Biol. 2008;377:1251-64 pubmed publisher
    ..The results also show that the stability of the turn is unlikely to be the prime determinant of formation of turn structure in the folding transition state. ..
  55. Wolańska M, Bańkowska Guszczyn E, Jaworski S. [Fibroblast growth factor gene expression in uterine leiomyomas]. Ginekol Pol. 2008;79:555-9 pubmed
    ..The collagenolitic activity was detected by zymography. A distinct increase in the expression of aFGF, the amounts of both FGFs, and collagenolitic activity was observed during the tumour growth...
  56. Winge S, Nielsen J, Jørgensen A, Owczarek S, Ewen K, Nielsen J, et al. Biglycan is a novel binding partner of fibroblast growth factor receptor 3c (FGFR3c) in the human testis. Mol Cell Endocrinol. 2015;399:235-43 pubmed publisher
    ..Based on expression patterns and homology to the binding site, we identified FGF1, FGF2, and FGF9 as the best candidates for natural ligands of FGFR3c in the testis...
  57. Delmas E, Jah N, Pirou C, Bouleau S, Le Floch N, Vayssière J, et al. FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities. Cell Death Dis. 2016;7:e2079 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1) is a prototypic member of the FGFs family overexpressed in various tumors. Contrarily to most FGFs, FGF1 lacks a secretion peptide signal and acts mainly in an intracellular and nuclear manner...
  58. Lu Y, Ye Y, Yang Q, Shi S. Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes. Kidney Int. 2017;92:504-513 pubmed publisher
    ..11 (Angpt2, Anxa5, Axl, Ecm1, Eng, Fn1, Mfge8, Msn, Nrp1, Serpine2, and Sparc) were upregulated, while 2 (Apoe and Fgf1) were downregulated in various glomerulopathies...
  59. Tribulo P, Siqueira L, Oliveira L, Scheffler T, Hansen P. Identification of potential embryokines in the bovine reproductive tract. J Dairy Sci. 2018;101:690-704 pubmed publisher
    ..CCL26, CTGF, CXCL12, IGF2, IL16, IL33, SFRP2, and WIF1), 2 at d 3 (HDGF, IL15), 14 at d 5 (CSF2, CX3CL1, CXCL3, FGF1, FGF2, GRO1, HGF, IGF1, IL1B, IL8, SFRP1, SFRP4, WNT5A, and WNT16), and 7 at d 7 (CXCL16, FGF13, HDGFRP2, TDGF1, ..
  60. Lee J, Dubey V, Somasundaram T, Blaber M. Conversion of type I 4:6 to 3:5 beta-turn types in human acidic fibroblast growth factor: effects upon structure, stability, folding, and mitogenic function. Proteins. 2006;62:686-97 pubmed
    ..Although the results suggest that a stable, foldable beta-trefoil protein may be designed utilizing a single turn type (type I 3:5), a type I 4:6 turn at turn 1 of FGF-1 appears essential for efficient mitogenic function. ..
  61. Ramos C, Montaño M, Becerril C, Cisneros Lira J, Barrera L, Ruiz V, et al. Acidic fibroblast growth factor decreases alpha-smooth muscle actin expression and induces apoptosis in human normal lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2006;291:L871-9 pubmed
    ..FGF-1 alone exhibited similar but lower effects. These findings suggest that FGF-1 can have an antifibrogenic role, inducing apoptosis of fibroblasts and inhibiting myofibroblast differentiation. ..
  62. Lu R, Ito J, Iwamoto N, Nishimaki Mogami T, Yokoyama S. FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res. 2009;50:1156-64 pubmed publisher
    b>Fibroblast growth factor 1 (FGF-1) enhances apolipoprotein E (apoE) expression and apoE-HDL biogenesis in autocrine fashion in astrocytes (Ito, J., Y. Nagayasu, R. Lu, A. Kheirollah, M. Hayashi, and S. Yokoyama...
  63. Harper J, Strydom D, Lobb R. Human class 1 heparin-binding growth factor: structure and homology to bovine acidic brain fibroblast growth factor. Biochemistry. 1986;25:4097-103 pubmed
  64. Pineda Lucena A, Jimenez M, Nieto J, Santoro J, Rico M, Gimenez Gallego G. 1H-NMR assignment and solution structure of human acidic fibroblast growth factor activated by inositol hexasulfate. J Mol Biol. 1994;242:81-98 pubmed
    ..The computed three-dimensional structure suggests that inositol hexasulfate may stabilize and activate the protein by conferring rigidity to the hairpin involving beta-strands 10 and 11. ..
  65. Cailliau K, Lescuyer A, Burnol A, Cuesta Marbán Ã, Widmann C, Browaeys Poly E. RasGAP Shields Akt from Deactivating Phosphatases in Fibroblast Growth Factor Signaling but Loses This Ability Once Cleaved by Caspase-3. J Biol Chem. 2015;290:19653-65 pubmed publisher
    ..Here, we investigated in Xenopus oocytes the impact of RasGAP and its fragments on FGF1-mediated signaling during G2/M cell cycle transition...
  66. Li M, Page McCaw P, Chen W. FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 2016;65:96-109 pubmed publisher
    ..We identified Fgf1 signaling as a key component of the overnutrition-induced β-cell differentiation signal in a small molecule ..
  67. Gautschi P, Frater Schröder M, Bohlen P. Partial molecular characterization of endothelial cell mitogens from human brain: acidic and basic fibroblast growth factors. FEBS Lett. 1986;204:203-7 pubmed
    ..sequences, the two proteins are structurally closely related to bovine acidic and basic fibroblast growth factors (aFGF, bFGF)...
  68. Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, et al. Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimer's disease. Biochem Biophys Res Commun. 2004;321:320-3 pubmed
    b>Fibroblast growth factor 1 (FGF1, also known as acidic FGF) protects selective neuronal populations against neurotoxic effects such as those in Alzheimer's disease (AD) and HIV encephalitis...
  69. Roodhart J, Langenberg M, Vermaat J, Lolkema M, Baars A, Giles R, et al. Late release of circulating endothelial cells and endothelial progenitor cells after chemotherapy predicts response and survival in cancer patients. Neoplasia. 2010;12:87-94 pubmed
    ..The correlation with a clinical response and survival provides further support for the biologic relevance of these cells in patients' prognosis and stresses their possible use as a therapeutic target. ..
  70. Bian J, Zhao H, Zhang Z, Bi X, Zhang J. No association of the C>T polymorphism that is located 1385 upstream from initial code of fibroblast growth factor 1 gene with Alzheimer's disease in Chinese. Brain Res. 2010;1328:113-7 pubmed publisher
    Several lines of evidence indicate that fibroblast growth factor 1 (FGF1) confers neuroprotection against excitotocity and contributes to the selective vulnerability of neurons in entorhinal cortex in Alzheimer's disease (AD)...
  71. Ha J, Kim H, Moon K, Jeon J, Jung D, Kim S, et al. Recombinant Human Acidic Fibroblast Growth Factor (aFGF) Expressed in Nicotiana benthamiana Potentially Inhibits Skin Photoaging. Planta Med. 2017;83:862-869 pubmed publisher
    ..in the pharmaceutical and cosmetic industries, we established a scalable expression system for recombinant human aFGF using transient and a DNA replicon vector expression in Nicotiana benthamiana...
  72. Chiu I, Wang W, Lehtoma K. Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1. Oncogene. 1990;5:755-62 pubmed
    ..3 kbp. By using the HBGF-1 cDNA as a probe, we showed that human fetal heart expresses high levels of HBGF-1 mRNA. Thus, HBGF-1 may be involved in mediating processes such as embryonic development and vascular growth in the heart. ..
  73. Trentin A, Alvarez Silva M, Moura Neto V. Thyroid hormone induces cerebellar astrocytes and C6 glioma cells to secrete mitogenic growth factors. Am J Physiol Endocrinol Metab. 2001;281:E1088-94 pubmed
    ..of T(3) could be due, at least in part, to the astrocyte secretion of acidic and basic fibroblast growth factor (aFGF and bFGF), tumor necrosis factor-beta, and transforming growth factor-beta...
  74. Zuo P, Rabie A. Novel method of cell-free in vitro synthesis of the human fibroblast growth factor 1 gene. J Biomed Biotechnol. 2010;2010: pubmed publisher
    ..based on Taq polymerase for the precise assembly of DNA oligonucleotides to yield the complete human fibroblast growth factor 1 (FGF1) gene, which is 468 bp long and has a G+C content of 51.5%...
  75. Rafiqdoost Z, Rafiqdoost A, Rafiqdoost H, Hashemi M, Khayatzadeh J, Eskandari Nasab E. Investigation of FGF1 and FGFR gene polymorphisms in a group of Iranian patients with nonsyndromic cleft lip with or without cleft palate. Int J Pediatr Otorhinolaryngol. 2014;78:731-6 pubmed publisher
    ..The aim of the current study was to assess the possible association between FGF1 rs34010 C>A and FGFR1 rs13317 A>G gene polymorphisms and susceptibility to NS-CL/P in an Iranian population...
  76. Ghazavi H, Hoseini S, Ebrahimzadeh Bideskan A, Mashkani B, Mehri S, Ghorbani A, et al. Fibroblast Growth Factor Type 1 (FGF1)-Overexpressed Adipose-Derived Mesenchaymal Stem Cells (AD-MSCFGF1) Induce Neuroprotection and Functional Recovery in a Rat Stroke Model. Stem Cell Rev. 2017;13:670-685 pubmed publisher
    ..Since FGF1 (fibroblast growth factor 1) displays neuroprotective properties, for the first time, we investigated the effect of acute ..
  77. Jayanthi S, Gundampati R, Kumar T. Simple and Efficient Purification of Recombinant Proteins Using the Heparin-Binding Affinity Tag. Curr Protoc Protein Sci. 2017;90:6.16.1-6.16.13 pubmed publisher
    ..Based on the structural knowledge available from the FGF1-heparin interaction studies, we have designed a novel heparin-binding peptide (HBP) affinity tag that can be used ..
  78. Yu Y, Kha H, Golden J, Migchielsen A, Goetzl E, Turck C. An acidic fibroblast growth factor protein generated by alternate splicing acts like an antagonist. J Exp Med. 1992;175:1073-80 pubmed
    ..The truncated variant of acidic fibroblast growth factor (aFGF') is only 60 amino acids long with an apparent molecular mass of 6...
  79. Zhao X, Yeoh T, Hiebert M, Frist W, Miller G. The expression of acidic fibroblast growth factor (heparin-binding growth factor-1) and cytokine genes in human cardiac allografts and T cells. Transplantation. 1993;56:1177-82 pubmed
    ..used to detect the expression of IL-1, IL-2, IL-4, IL-5, IL-6, TNF-alpha, IFN-gamma, TGF-beta, TCR-beta chain and aFGF genes in 21 myocardial biopsies obtained from 9 heart transplant patients...
  80. Chotani M, Payson R, Winkles J, Chiu I. Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol ester. Nucleic Acids Res. 1995;23:434-41 pubmed
    ..Our findings suggest that different FGF-1 promoters may respond to different physiological conditions and stimuli, in reference to the cell type or tissue milieu, resulting in ultimate production of the FGF-1 protein. ..
  81. Shin J, Opalenik S, Wehby J, Mahesh V, Jackson A, Tarantini F, et al. Serum-starvation induces the extracellular appearance of FGF-1. Biochim Biophys Acta. 1996;1312:27-38 pubmed
    ..Analysis of the conditioned media from these stressed cells indicated that serum starvation induces the secretion of FGF-1 as latent high molecular mass complexes requiring reducing agents to activate its full biological potential. ..
  82. Martineau Y, Le Bec C, Monbrun L, Allo V, Chiu I, Danos O, et al. Internal ribosome entry site structural motifs conserved among mammalian fibroblast growth factor 1 alternatively spliced mRNAs. Mol Cell Biol. 2004;24:7622-35 pubmed
    b>Fibroblast growth factor 1 (FGF-1) is a powerful angiogenic factor whose gene structure contains four promoters, giving rise to a process of alternative splicing resulting in four mRNAs with alternative 5' untranslated regions (5' UTRs)...
  83. Wesche J, Małecki J, Wiedłocha A, Skjerpen C, Claus P, Olsnes S. FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. J Biol Chem. 2006;281:11405-12 pubmed
    Similarly to many protein toxins, the growth factors fibroblast growth factor 1 (FGF-1) and FGF-2 translocate from endosomes into the cytosol...
  84. Butt C, Lim S, Greenwood C, Rahman P. VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis. BMC Musculoskelet Disord. 2007;8:1 pubmed
    ..vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and fibroblast growth factors 1 and 2 (FGF1 and FGF2) play a central role in the initiation of angiogenesis...
  85. Tomlinson D, Knowles M. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer. Am J Pathol. 2010;177:2379-86 pubmed publisher
    ..FGFR1? showed higher affinity for low concentrations of FGF1, leading to enhanced signaling and increased proliferation...
  86. Henriksson M, Edin S, Dahlin A, Oldenborg P, Oberg A, Van Guelpen B, et al. Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion. Am J Pathol. 2011;178:1387-94 pubmed publisher
    ..We identify fibroblast growth factor 1/fibroblast growth factor receptor 3 (FGF1/FGFR-3) signaling as mediators leading to the increased ..
  87. Bojesen K, Clausen O, Rohde K, Christensen C, Zhang L, Li S, et al. Nectin-1 binds and signals through the fibroblast growth factor receptor. J Biol Chem. 2012;287:37420-33 pubmed publisher
    ..Finally, we constructed a peptide, nectide, by employing in silico modeling of various FGFR ligand-binding sites. Nectide mimicked all the effects of nectin-1 Ig3. We suggest that FGFR is a downstream signaling partner of nectin-1. ..
  88. Huang C, Liu Y, Beenken A, Jiang L, Gao X, Huang Z, et al. A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration. Cardiovasc Res. 2017;113:1585-1602 pubmed publisher
    b>Fibroblast growth factor 1 (FGF1), a heparin/heparan sulfate-binding growth factor, is a potent cardioprotective agent against myocardial infarction (MI)...
  89. Ostrovsky O, Berman B, Gallagher J, Mulloy B, Fernig D, Delehedde M, et al. Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes. J Biol Chem. 2002;277:2444-53 pubmed
    ..These different requirements may reflect the differences in the mode by which a given FGFR interacts with the various FGFs. ..
  90. Schilling T, Küffner R, Klein Hitpass L, Zimmer R, Jakob F, Schutze N. Microarray analyses of transdifferentiated mesenchymal stem cells. J Cell Biochem. 2008;103:413-33 pubmed
    ..b>Fibroblast growth factor 1 (FGF1) was scored as one of several lead candidate gene products to modulate the transdifferentiation ..
  91. Jungerius B, Hoogendoorn M, Bakker S, van t Slot R, Bardoel A, Ophoff R, et al. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. Mol Psychiatry. 2008;13:1060-8 pubmed
    ..We also report weak association of SNPs in PIK3C2G, FGF1, FGFR1, ARHGEF10 and PSAP (observed P<or=0.01)...
  92. Kathir K, Gao L, Rajalingam D, Daily A, Brixey S, Liu H, et al. NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1). Biochim Biophys Acta. 2010;1798:297-302 pubmed publisher
    ..The results of this study provide valuable information towards understanding the molecular mechanism of the Cu(2+)-induced non-classical secretion of hFGF-1. ..