FGD5

Summary

Gene Symbol: FGD5
Description: FYVE, RhoGEF and PH domain containing 5
Alias: ZFYVE23, FYVE, RhoGEF and PH domain-containing protein 5, zinc finger FYVE domain-containing protein 23
Species: human
Products:     FGD5

Top Publications

  1. Reuter M, Jobling R, Chaturvedi R, Manshaei R, Costain G, Heung T, et al. Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot. Genet Med. 2018;: pubmed publisher
    ..likely disruptive variants in VEGF-related genes: KDR (VEGFR2; two stopgain and two nonsynonymous variants), VEGFA, FGD5, BCAR1, IQGAP1, FOXO1, and PRDM1. Detection of VEGF-related variants (19/175, 10...
  2. Hernández García R, Iruela Arispe M, Reyes Cruz G, Vázquez Prado J. Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascul Pharmacol. 2015;74:60-72 pubmed publisher
    ..Among them, we found that the most abundant endothelial RhoGEFs were: Tuba, FGD5, Farp1, ARHGEF17, TRIO, P-Rex1, ARHGEF15, ARHGEF11, ABR, Farp2, ARHGEF40, ALS, DOCK1, DOCK7 and DOCK6...
  3. Heldin J, O Callaghan P, Hernández Vera R, Fuchs P, Gerwins P, Kreuger J. FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation. Cell Signal. 2017;40:125-132 pubmed publisher
    The complete repertoire of endothelial functions elicited by FGD5, a guanine nucleotide exchange factor activating the Rho GTPase Cdc42, has yet to be elucidated...
  4. Kurogane Y, Miyata M, Kubo Y, Nagamatsu Y, Kundu R, Uemura A, et al. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32:988-96 pubmed publisher
    ..we attempted to clarify the expression, subcellular localization, downstream effectors, and proangiogenic role of FGD5, a member of the FGD family of guanine nucleotide exchange factors...
  5. Niu X, Chang W, Liu R, Hou R, Li J, Wang C, et al. Expression of pro-angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis. Int J Dermatol. 2016;55:e280-8 pubmed publisher
    ..that the pro-angiogenic genes platelet endothelial cell adhesion molecule-1 (PECAM1), facio-genital dysplasia-5 (FGD5), prostaglandin-endoperoxide synthase-1 (PTGS1), melanoma cell adhesion molecule (MCAM), vasohibin-2 (VASH2), and ..
  6. Farhan M, Azad A, Touret N, Murray A. FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling. Arterioscler Thromb Vasc Biol. 2017;37:2301-2310 pubmed publisher
    ..b>FGD5 (faciogenital dysplasia-5)-a Rho-family guanine nucleotide exchange factor-is selectively expressed in EC...
  7. Cheng C, Haasdijk R, Tempel D, van de Kamp E, Herpers R, Bos F, et al. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. Circulation. 2012;125:3142-58 pubmed publisher
    ..approach, we identified a new endothelial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) that plays a crucial role in vascular pruning...
  8. Nakhaei Nejad M, Haddad G, Zhang Q, Murray A. Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32:2694-701 pubmed publisher
    ..of the endothelial cell (EC)-enriched Rho family guanine nucleotide exchange factor, facio-genital dysplasia-5 (FGD5), is poorly understood...
  9. Tornack J, Kawano Y, Garbi N, Hämmerling G, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017;47:1477-1487 pubmed publisher
    ..cells express hypoxia, autophagy-inducing, and the LT-HSC-associated genes HoxB5 and Fgd5, while Flt3L-eGFP-reporterhigh HSCs upregulate genes involved in HSC differentiation...

More Information

Publications11

  1. Valla M, Engstrøm M, Ytterhus B, Hansen Å, Akslen L, Vatten L, et al. FGD5 amplification in breast cancer patients is associated with tumour proliferation and a poorer prognosis. Breast Cancer Res Treat. 2017;162:243-253 pubmed publisher
    Proliferation is a hallmark of cancer. Using a combined genomic approach, FGD5 amplification has been identified as a driver of proliferation in Luminal breast cancer...
  2. Ge R, Tornero D, Hirota M, Monni E, Laterza C, Lindvall O, et al. Choroid plexus-cerebrospinal fluid route for monocyte-derived macrophages after stroke. J Neuroinflammation. 2017;14:153 pubmed publisher
    ..Infiltration of MDMs into CP and CSF were validated using ?-actin-GFP chimeric mice and Fgd5-CreERT2 x Lox-stop-lox-Tomato mice...