Gene Symbol: FGD5
Description: FYVE, RhoGEF and PH domain containing 5
Alias: ZFYVE23, FYVE, RhoGEF and PH domain-containing protein 5, zinc finger FYVE domain-containing protein 23
Reuter M, Jobling R, Chaturvedi R, Manshaei R, Costain G, Heung T, et al
. Haploinsufficiency of vascular endothelial growth factor related signaling genes is associated with tetralogy of Fallot. Genet Med. 2018;: pubmed publisher
..likely disruptive variants in VEGF-related genes: KDR (VEGFR2; two stopgain and two nonsynonymous variants), VEGFA, FGD5, BCAR1, IQGAP1, FOXO1, and PRDM1. Detection of VEGF-related variants (19/175, 10...
HernÃ¡ndez GarcÃa R, Iruela Arispe M, Reyes Cruz G, VÃ¡zquez Prado J. Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascul Pharmacol. 2015;74:60-72 pubmed publisher
..Among them, we found that the most abundant endothelial RhoGEFs were: Tuba, FGD5, Farp1, ARHGEF17, TRIO, P-Rex1, ARHGEF15, ARHGEF11, ABR, Farp2, ARHGEF40, ALS, DOCK1, DOCK7 and DOCK6...
Heldin J, O Callaghan P, Hernández Vera R, Fuchs P, Gerwins P, Kreuger J. FGD5 sustains vascular endothelial growth factor A (VEGFA) signaling through inhibition of proteasome-mediated VEGF receptor 2 degradation. Cell Signal. 2017;40:125-132 pubmed publisher
The complete repertoire of endothelial functions elicited by FGD5, a guanine nucleotide exchange factor activating the Rho GTPase Cdc42, has yet to be elucidated...
Kurogane Y, Miyata M, Kubo Y, Nagamatsu Y, Kundu R, Uemura A, et al
. FGD5 mediates proangiogenic action of vascular endothelial growth factor in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32:988-96 pubmed publisher
..we attempted to clarify the expression, subcellular localization, downstream effectors, and proangiogenic role of FGD5, a member of the FGD family of guanine nucleotide exchange factors...
Niu X, Chang W, Liu R, Hou R, Li J, Wang C, et al
. Expression of pro-angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis. Int J Dermatol. 2016;55:e280-8 pubmed publisher
..that the pro-angiogenic genes platelet endothelial cell adhesion molecule-1 (PECAM1), facio-genital dysplasia-5 (FGD5), prostaglandin-endoperoxide synthase-1 (PTGS1), melanoma cell adhesion molecule (MCAM), vasohibin-2 (VASH2), and ..
Farhan M, Azad A, Touret N, Murray A. FGD5 Regulates VEGF Receptor-2 Coupling to PI3 Kinase and Receptor Recycling. Arterioscler Thromb Vasc Biol. 2017;37:2301-2310 pubmed publisher
..b>FGD5 (faciogenital dysplasia-5)-a Rho-family guanine nucleotide exchange factor-is selectively expressed in EC...
Cheng C, Haasdijk R, Tempel D, van de Kamp E, Herpers R, Bos F, et al
. Endothelial cell-specific FGD5 involvement in vascular pruning defines neovessel fate in mice. Circulation. 2012;125:3142-58 pubmed publisher
..approach, we identified a new endothelial specific gene named FYVE, RhoGEF, and PH domain-containing 5 (FGD5) that plays a crucial role in vascular pruning...
Nakhaei Nejad M, Haddad G, Zhang Q, Murray A. Facio-genital dysplasia-5 regulates matrix adhesion and survival of human endothelial cells. Arterioscler Thromb Vasc Biol. 2012;32:2694-701 pubmed publisher
..of the endothelial cell (EC)-enriched Rho family guanine nucleotide exchange factor, facio-genital dysplasia-5 (FGD5), is poorly understood...
Tornack J, Kawano Y, Garbi N, Hämmerling G, Melchers F, Tsuneto M. Flt3 ligand-eGFP-reporter expression characterizes functionally distinct subpopulations of CD150+ long-term repopulating murine hematopoietic stem cells. Eur J Immunol. 2017;47:1477-1487 pubmed publisher
..cells express hypoxia, autophagy-inducing, and the LT-HSC-associated genes HoxB5 and Fgd5, while Flt3L-eGFP-reporterhigh HSCs upregulate genes involved in HSC differentiation...