FFAR4

Summary

Gene Symbol: FFAR4
Description: free fatty acid receptor 4
Alias: BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4, free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, omega-3 fatty acid receptor 1
Species: human

Top Publications

  1. ncbi Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    Akira Hirasawa
    Department of Molecular, Cell Pharmacology, National Research Institute for Child Health and Development, 3 35 31, Taishi do, Setagaya Ku, Tokyo 154 8567, Japan
    Nat Med 11:90-4. 2005
  2. doi Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis
    Atsuhiko Ichimura
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Prostaglandins Other Lipid Mediat 89:82-8. 2009
  3. doi Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor
    Rebecca N Burns
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
    Biochem Biophys Res Commun 396:1030-5. 2010
  4. pmc GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    Da Young Oh
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 142:687-98. 2010
  5. doi G protein-coupled receptors in human fat taste perception
    Maria Mercedes Galindo
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Chem Senses 37:123-39. 2012
  6. pmc Differential signaling by splice variants of the human free fatty acid receptor GPR120
    Sarah Jane Watson
    Cell Signalling Research Group, School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
    Mol Pharmacol 81:631-42. 2012
  7. doi Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
    Atsuhiko Ichimura
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nature 483:350-4. 2012
  8. ncbi The combined effects of genetic variations in the GPR120 gene and dietary fat intake on obesity risk
    Toshiharu Waguri
    Laboratory of Human Genetics, School of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Biomed Res 34:69-74. 2013
  9. doi Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma
    Q Wu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine SJTUSM and Shanghai Institute of Immunology, Institutes of Medical Sciences, SJTUSM, Shanghai, China
    Oncogene 32:5541-50. 2013
  10. doi Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation
    Omar B Sánchez-Reyes
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Ap Postal 70 248, Mexico D F 04510, Mexico
    Eur J Pharmacol 723:368-74. 2014

Research Grants

  1. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
  2. The role of phosphorylation in regulating the antidiabetic effects of O3FAR-1
    Nader H Moniri; Fiscal Year: 2013
  3. Rachana Shah; Fiscal Year: 2015
  4. Ruth E Patterson; Fiscal Year: 2015
  5. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
  6. W SUE RITTER; Fiscal Year: 2016

Scientific Experts

Detail Information

Publications171 found, 100 shown here

  1. ncbi Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120
    Akira Hirasawa
    Department of Molecular, Cell Pharmacology, National Research Institute for Child Health and Development, 3 35 31, Taishi do, Setagaya Ku, Tokyo 154 8567, Japan
    Nat Med 11:90-4. 2005
    ..Here we show that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs...
  2. doi Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis
    Atsuhiko Ichimura
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Prostaglandins Other Lipid Mediat 89:82-8. 2009
    ..demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120)...
  3. doi Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor
    Rebecca N Burns
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
    Biochem Biophys Res Commun 396:1030-5. 2010
    The newly discovered G protein-coupled receptor GPR120 has recently been shown to stimulate secretion of the gut hormones glucagon-like peptide-1 and cholecystokinin upon binding of free fatty acids, thrusting it to the forefront of drug ..
  4. pmc GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects
    Da Young Oh
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 142:687-98. 2010
    ..Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor...
  5. doi G protein-coupled receptors in human fat taste perception
    Maria Mercedes Galindo
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Chem Senses 37:123-39. 2012
    ..We demonstrated that the pharmacological activation profile of human GPR40 and GPR120, 2 LCFA-specific receptors associated with gustatory fat perception in rodents, is inconsistent with the "scratchy"..
  6. pmc Differential signaling by splice variants of the human free fatty acid receptor GPR120
    Sarah Jane Watson
    Cell Signalling Research Group, School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
    Mol Pharmacol 81:631-42. 2012
    b>GPR120 is a long-chain fatty acid receptor that stimulates incretin hormone release from colonic endocrine cells and is implicated in macrophage and adipocyte function...
  7. doi Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human
    Atsuhiko Ichimura
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8501, Japan
    Nature 483:350-4. 2012
    ..b>GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role ..
  8. ncbi The combined effects of genetic variations in the GPR120 gene and dietary fat intake on obesity risk
    Toshiharu Waguri
    Laboratory of Human Genetics, School of Food and Nutritional Sciences, Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Biomed Res 34:69-74. 2013
    ..3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects, and the G protein-coupled receptor GPR120 was reported to mediate the anti-inflammatory effects of ω-3 PUFAs...
  9. doi Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma
    Q Wu
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine SJTUSM and Shanghai Institute of Immunology, Institutes of Medical Sciences, SJTUSM, Shanghai, China
    Oncogene 32:5541-50. 2013
    G-protein-coupled receptor 120 (GPR120) functions as a receptor for unsaturated long-chain free fatty acids and has an important role in regulating lipid and glucose metabolism...
  10. doi Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation
    Omar B Sánchez-Reyes
    Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Ap Postal 70 248, Mexico D F 04510, Mexico
    Eur J Pharmacol 723:368-74. 2014
    GPR120, free fatty acid receptor 4, is a recently deorphanized G protein-coupled receptor that seems to play cardinal roles in the regulation of metabolism and in the pathophysiology of inflammatory and metabolic disorders...
  11. pmc Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³⁴⁷, Ser³⁵⁰, and Ser³⁵⁷ in the C-terminal tail
    Rebecca N Burns
    Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, Atlanta, GA 30341, USA
    Biochem Pharmacol 87:650-9. 2014
    b>Free fatty acid receptor 4 (FFA4), previously known as GPR120, is a G protein-coupled receptor that promotes numerous anti-inflammatory and antidiabetic effects upon its agonism by long chained unsaturated fatty acids...
  12. pmc CD36- and GPR120-mediated Ca²⁺ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice
    Mehmet Hakan Ozdener
    Monell Chemical Senses Center, Philadelphia, Pennsylvania
    Gastroenterology 146:995-1005. 2014
    ..We studied the roles of the fat taste receptors CD36 and GPR120 and their interactions via Ca(2+) signaling in fungiform taste bud cells (TBC).
  13. pmc Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4
    Adrian J Butcher
    From the Medical Research Council Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, United Kingdom
    J Biol Chem 289:18451-65. 2014
    ..Among these is FFA4, previously called GPR120, which responds to medium and long chain fatty acids, including health-promoting ω-3 fatty acids, which have been ..
  14. doi Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants
    Kristina Moore
    Dept of Cardiovascular Metabolic Disease, Schering Plough Research Institute, Kenilworth, NJ 07033, USA
    Comp Biochem Physiol B Biochem Mol Biol 154:419-26. 2009
    Activation of the GPCR GPR120 by free fatty acids has been reported to cause GLP-1 release in rodent intestine. One genetic sequence was reported for rodents, while two sequences were reported for human GPR120, BC101175 and NM_181745...
  15. pmc Preference for linoleic acid in obesity-prone and obesity-resistant rats is attenuated by the reduction of CD36 on the tongue
    Christina S Y Chen
    Joint Diabetes, Endocrinology and Metabolism Program, Louisiana State University System, Louisiana State University Health Science Center New Orleans, New Orleans, Lousiana and
    Am J Physiol Regul Integr Comp Physiol 305:R1346-55. 2013
    ..threshold were related to innate strain differences in the fatty acid receptors on the tongue, the expression of GPR120, GPR40, and CD36 on the circumvallate papillae were assessed in OM and S5B rats...
  16. pmc A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice
    Da Young Oh
    Division of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California, USA
    Nat Med 20:942-7. 2014
    ..We reported that Gpr120 is the functional receptor for these fatty acids and that ω-3-FAs produce robust anti-inflammatory, insulin-..
  17. pmc The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120
    Mikael Bjursell
    AstraZeneca R and D, Molndal, Sweden
    PLoS ONE 9:e114942. 2014
    b>GPR120 (Ffar4) has been postulated to represent an important receptor mediating the improved metabolic profile seen upon ingestion of a diet enriched in polyunsaturated fatty acids (PUFAs)...
  18. doi Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels
    Amelie Bonnefond
    CNRS UMR8199, Lille Pasteur Institute, Lille, France Lille University, Lille, France European Genomic Institute for Diabetes EGID, Lille, France
    J Med Genet 52:595-8. 2015
    We previously reported that the low-frequency, loss-of-function variant p.R270H in FFAR4 encoding the lipid sensor GPR120 was associated with obesity...
  19. pmc Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon
    Ameneh Cheshmehkani
    Department of Pharmaceutical Sciences, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA, 30341, USA
    Inflamm Res 64:809-15. 2015
    ..One such receptor, free-fatty acid receptor-4 (FFAR4), previously described as GPR120, has been shown to modulate anti-inflammatory and insulin-sensitizing effects in response to PUFA such as ALA and ..
  20. doi Diets Containing α-Linolenic (ω3) or Oleic (ω9) Fatty Acids Rescues Obese Mice From Insulin Resistance
    V Oliveira
    Laboratories of Nutritional Genomics V O, D E C, Limeira 13484 350, Cell Signaling V O, D V, J C M, N D, L A V, D E C, and Molecular Biology of Exercise R M, L P, A S R d S, E R R, J R P Innovare G A S, R R C and Nutrigenomics and Lipids Center A S C, D E C and Biotechnology Center E R R, J R P, D E C, School of Applied Sciences, State University of Campinas, Campinas, Brazil 13083 887 and Laboratory of Exercise Biochemistry and Physiology C T D S, Health Sciences Unit, Universidade do Extremo Sul Catarinense Criciúma, Brazil 88806 000
    Endocrinology 156:4033-46. 2015
    ..b>GPR120 was activated in liver, skeletal muscle, and adipose tissues, reverting inflammation and insulin resistance in ..
  21. pmc Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice
    Stephanie Auguste
    CRCHUM and Montreal Diabetes Research Center Drs Auguste, Fisette, and Fernandes, Ms Hryhorczuk, and Drs Poitout, Alquier, and Fulton Department of Nutrition Drs Auguste, Fisette, and Fulton, Department of Physiology Dr Fernandes and Ms Hryhorczuk, and Department of Medicine Drs Poitout and Alquier, Faculty of Medicine, Universite de Montreal, QC, Canada
    Int J Neuropsychopharmacol 19:. 2016
    b>GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and the antiinflammatory and insulin-sensitizing effects of omega-3 (ω-3) polyunsaturated fatty acids...
  22. doi Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population
    Marie A Vestmar
    Department of Neuroscience and Pharmacology, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark Section for Metabolic Receptology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    J Med Genet 53:616-23. 2016
    p.R270H (rs116454156) in the long chain fatty acid 7TM receptor FFAR4 (GPR120) which results in impaired Gαq (Gq) coupled signalling, has been associated with obesity. We aimed to extend the functional in vitro analyses of p...
  23. doi Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study
    A Lamri
    Institut National de la Sante et de la Recherche Medicale INSERM, Centre de Recherches des Cordeliers, Research Unit 1138, Paris, France Paris Diderot University, Sorbonne Paris Cité, Paris, France Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
    Nutr Metab Cardiovasc Dis 26:931-6. 2016
    b>GPR120 (encoded by FFAR4) is a lipid sensor that plays an important role in the control of energy balance. GPR120 is activated by long chain fatty acids (FAs) including omega-3 FAs. In humans, the loss of function p...
  24. ncbi Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120)
    Steffen V F Hansen
    Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230, Odense M, Denmark
    Handb Exp Pharmacol . 2016
    The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, ..
  25. doi Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects
    Matthew Lombardo
    Merck and Co, Inc, Kenilworth, NJ, USA Electronic address
    Bioorg Med Chem Lett 26:5724-5728. 2016
    ..ultra high-throughput screening (uHTS) hit into a potent and selective series of G-protein coupled receptor 120 (GPR120) agonists is reported...
  26. pmc Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB
    Jeanne Durendale Chiadak
    Laboratory of Pathophysiological and Nutritional Biochemistry, Universite Libre de Bruxelles, Brussels, Belgium Department of Biochemistry, Faculty of Sciences, University of Dschang, Dschang, Cameroon
    Mediators Inflamm 2016:1431789. 2016
    ..In contrast, G-protein coupled receptor 120 (GPR120) mediates antiobesity effects...
  27. doi Pro-metastatic intracellular signaling of the elaidic trans fatty acid
    Kiyomu Fujii
    Department of Molecular Pathology, Nara Medical University, Kashihara 634 8521, Japan
    Int J Oncol 50:85-92. 2017
    ..EA-induced signaling were confirmed by determining the binding of EA to G-protein coupled receptor 40 (GPR40) and GPR120 by performing surface protein internalization assay...
  28. doi Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states
    Dan Zhang
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Clin Sci (Lond) 131:247-260. 2017
    G-protein-coupled receptor 120 (GPR120) is a putative target for obesity and diabetes therapies. However, it remains controversial whether resident GPR120 plays a direct regulatory role in islet β-cell insulin secretion...
  29. pmc Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists
    Jason M Cox
    Merck and Co, Inc, Kenilworth, New Jersey 07033, United States Merck and Co, Inc, Rahway, New Jersey 07065, United States
    ACS Med Chem Lett 8:49-54. 2017
    ..G-protein coupled receptor 120 (GPR120) has recently emerged as a potential therapeutic target for treating T2DM...
  30. doi Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells.
    Kaede Takahashi
    Biochem Biophys Res Commun 484:675-680. 2017
    G-protein-coupled receptor 120 (GPR120) and GPR40 are members of free fatty acid (FFA) receptors and mediate a variety of biological responses through binding of medium- and long-chain FFAs...
  31. doi GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue.
    Tongxing Song
    Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China
    Cell Mol Life Sci 74:2723-2733. 2017
    ..G protein-coupled receptor 120 (GPR120) represents a promising target for the treatment of obesity-related metabolic disorders for its involvement in the ..
  32. doi Mechanisms and effects of "fat taste" in humans
    Robin M Tucker
    Department of Nutrition Science, Purdue University, West Lafayette, IN, USA
    Biofactors 40:313-26. 2014
    ..negotiate the aqueous environment to reach taste cell surfaces, and interact with receptors such as CD36 and GPR120 or diffuse across cell membranes to initiate a taste signal...
  33. pmc Potential roles of GPR120 and its agonists in the management of diabetes
    Dan Zhang
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong
    Drug Des Devel Ther 8:1013-27. 2014
    ..FFAR4 is also known as G-protein coupled receptor 120 (GPR120). The main role of GPR120 is to elicit FFA regulation on metabolism homeostasis...
  34. doi Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells
    Shuhei Ishii
    Division of Cancer Biology and Bioinformatics, Department of Life Science, Faculty of Science and Engineering, Kinki University, 3 4 1, Kowakae, Higashiosaka, Osaka, 577 8502, Japan
    Mol Cell Biochem 400:145-51. 2015
    G-protein-coupled receptor 120 (GPR120) is identified as a G-protein-coupled receptor for unsaturated long-chain free fatty acids that mediates insulin signaling and anti-inflammatory effects...
  35. doi The role of G-protein-coupled receptor 120 in fatty acids sensing in chicken oral tissues
    Ryo Sawamura
    Laboratory of Functional Anatomy, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 458:387-91. 2015
    ..Although fatty acids are partly recognized via G-protein coupled receptor 120 (GPR120) for fat taste in mammalian oral tissues, the fat taste receptor of chickens has not been elucidated...
  36. pmc Genetic variants of the unsaturated fatty acid receptor GPR120 relating to obesity in dogs
    Masahiro Miyabe
    Department of Veterinary Nursing, School of Veterinary Nursing and Technology, Faculty of Veterinary Science, Nippon Veterinary and Life Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    J Vet Med Sci 77:1201-6. 2015
    ..It is reported that the genetic variant of GPR120, p...
  37. doi FFA4 receptor (GPR120): A hot target for the development of anti-diabetic therapies
    Hong Da Liu
    Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, Shandong University, School of Medicine, Jinan, Shandong, China Qilu Hospital of Shandong University, Jinan, Shandong, China Shandong Provincial School Key Laboratory for Protein Science of Chronic Degenerative Diseases, Jinan, Shandong, China
    Eur J Pharmacol 763:160-8. 2015
    Free Fatty Acid 4 receptor (FFA4 receptor or GPR120), a rhodopsin-like G protein coupled receptor (GPCR) subfamily member, is a receptor that senses specific fatty acids such as ω-3 fatty acid in fish oil or the endogenous signaling ..
  38. doi Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells
    Kristoffer L Egerod
    Novo Nordisk Foundation Center for Basic Metabolic Research K L E, M S E, M L L, K V G, M Z, D B J, E B N, n p, J J H, T W S, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark Laboratory for Molecular Pharmacology K L E, M S E, M L L, K V G, M Z, D B J, E B N, n p, T W S, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark Danish Diabetes Academy M S E, 5000 Odense, Denmark and Department of Biomedical Sciences J J H, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark
    Endocrinology 156:3909-23. 2015
    ..1) The metabolite receptors calcium-sensing receptor and free fatty acid receptor 4 (GPR120) functioned as positive and negative regulators, respectively...
  39. pmc Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction
    Sinju Sundaresan
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO and Department of Internal Medicine, Gastroenterology Division, University of Michigan, Ann Arbor, MI
    J Nutr 145:2195-200. 2015
    ..by these receptors are the long-chain fatty acids that act as ligands for 2 G protein-coupled receptors, GPR40 and GPR120, and the fatty acid (FA) translocase/CD36...
  40. doi Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP
    Dean Q Tran
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Cell Endocrinol 426:125-35. 2016
    ..AH7614, K252c, U0126, wortmannin, and LY294002, we demonstrate that the effect of DHA is mediated through GPR120 to downstream PKC/MAPK and PI3K signaling...
  41. pmc Mechanisms underlying glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 secretion
    Frank Reimann
    University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit WT MRC Institute of Metabolic Science Addenbrooke s Hospital Cambridge UK
    J Diabetes Investig 7:13-9. 2016
    ..both cell types produce the long-chain fatty acid sensing G-protein-coupled receptors, FFAR1 (GPR40) and FFAR4 (GPR120), but differ in the expression/functionality of other lipid sensing receptors...
  42. doi Fishing out a sensor for anti-inflammatory oils
    Alan R Saltiel
    Life Sciences Institute, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cell 142:672-4. 2010
    ..Now, Oh et al. (2010) demonstrate that the G protein-coupled receptor GPR120 is a receptor for omega-3 fatty acids on macrophages and fat cells...
  43. pmc Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice
    Xinping Lu
    Digestive Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Physiol Gastrointest Liver Physiol 303:G367-76. 2012
    ..immunofluorescence staining, we detected a high level of expression of the long-chain fatty acid (LCFA) receptor GPR120, while the other LCFA receptor, GPR40, was undetectable...
  44. doi Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
    Yiqing Yan
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Anhui 230027, China
    Immunity 38:1154-63. 2013
    ..In addition, G protein-coupled receptor 120 (GPR120) and GPR40 and their downstream scaffold protein β-arrestin-2 were shown to be involved in inflammasome ..
  45. pmc Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion
    Sarah Juel Paulsen
    Department of Histology, gubra, Hørsholm, Denmark
    PLoS ONE 9:e88227. 2014
    Stimulation of the G protein coupled receptor GPR120 has been shown to have anti-inflammatory and insulin-sensitizing effects, to promote glucagon like peptide-1 (GLP-1) secretion, and to play a key role in sensing dietary fat and control ..
  46. doi Exposure to omega-3 fatty acids at early age accelerate bone growth and improve bone quality
    Netta Koren
    Institute of Biochemistry and Nutrition, The Robert H Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel
    J Nutr Biochem 25:623-33. 2014
    ..We further propose that those effects are mediated by the receptors G-protein coupled receptor 120 (GPR120) and hepatic nuclear factor 4α, which are expressed by chondrocytes in culture...
  47. doi Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index
    Tanya J Little
    University of Adelaide Discipline of Medicine, Adelaide, South Australia, Australia National Health and Medical Research Council Centre of Research Excellence in Translating Nutritional Science to Good Health, Adelaide, South Australia, Australia and
    Am J Physiol Gastrointest Liver Physiol 307:G958-67. 2014
    ..a key role for the FA-sensing receptors cluster of differentiation (CD)36, G protein-coupled receptor (GPR)40, GPR120, and GPR119 in mediating gastrointestinal hormone secretion...
  48. pmc Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects
    Mark M Yore
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Cell 159:318-32. 2014
    ..PAHSAs also reduce adipose tissue inflammation. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake...
  49. doi Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells
    Bo Gao
    Institute of Orthopedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi an, People s Republic of China
    Stem Cells Dev 24:781-90. 2015
    ..Interestingly, Rb2 promoted GPR120 induction, which is the unsaturated long-chain fatty acid receptor...
  50. doi Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease
    Takuya Tsukahara
    Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 185:185-96. 2015
    ..A GLP-2 analogue has been an effective treatment for Crohn disease (CD). G-protein-coupled receptor (GPR) 40 and GPR120 are probably involved in GLP-2 production, the mechanisms of which remain unclear...
  51. doi Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells
    Shin ichi Adachi
    Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
    Biomed Res 35:357-67. 2014
    We recently reported that G-protein-coupled receptor 120 (GPR120) is expressed on taste buds, and that rodents showed preference for long-chain fatty acids (LCFA) at a low concentration...
  52. doi Functions of omega-3 fatty acids and FFA4 (GPR120) in macrophages
    Dong Soon Im
    Molecular Inflammation Research Center for Aging Intervention MRCA and College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea Electronic address
    Eur J Pharmacol 785:36-43. 2016
    ..receptor for long-chain unsaturated fatty acids, including n-3 PUFAs, and was recently renamed free fatty acid receptor 4 (FFA4)...
  53. pmc Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4
    Jung Min Kim
    Molecular Inflammation Research Center for Aging Intervention MRCA and College of Pharmacy, Pusan National University, Busan 609 735, Republic of Korea
    Acta Pharmacol Sin 36:813-20. 2015
    b>Free fatty acid receptor 4 (FFA4; formerly known as GPR120) is the G protein-coupled receptor (GPCR) for omega-3 polyunsaturated fatty acids. FFA4 has been found to express in the small intestines and colons of mice and humans...
  54. ncbi [Free Fatty Acid Receptor Family: A New Therapeutic Target for Metabolic Diseases]
    Akira Hirasawa
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Science, Kyoto University 46 29 Yoshida Shimo Adachi cho, Sakyo ku, Kyoto 606 8501 2 Inistitute for Integrated Medical Scinces, Tokyo Women s Medical University 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Yakugaku Zasshi 135:769-77. 2015
    ..In this free fatty acid receptor family, FFAR1 (GPR40) and FFAR4 (GPR120) are activated by long-chain FFAs...
  55. doi Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research
    Ang Li
    Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan, Shandong 250012, China
    Future Med Chem 7:1457-68. 2015
    b>GPR120 receptor functions as a receptor for ω-3 fatty acid, involving regulating the secretion of gastrointestinal peptide hormone, adipogenesis, adipogenic differentiation and anti-inflammatory process and the like in the aspect of ..
  56. ncbi GPR 120: The Potential Target for Obesity Treatment
    Peter A Tanagho
    Cairo University Hospitals, Al Saray St, El Maniel, 11451, Cairo, Egypt
    Endocr Metab Immune Disord Drug Targets 16:8-11. 2016
    b>G protein coupled receptor 120 (GPR120) is a class of receptors in the gastrointestinal tract (GIT) that is implicated in nutrient sensing and body weight regulation...
  57. doi Comprehensive Profiling of GPCR Expression in Ghrelin-Producing Cells
    Hiroyuki Koyama
    Medical Innovation Center H I, K D, M B, T K, C S, K H, K K, K N and Departments of Diabetes, Endocrinology, and Nutrition H K and Human Health Sciences K H, Kyoto University Graduate School of Medicine, Kyoto 606 8507, Japan National Cerebral and Cardiovascular Center Research Institute H H, K K, Osaka 565 8565 Japan and The First Department of Medicine H A, T A, Wakayama Medical University, Wakayama 641 8509, Japan
    Endocrinology 157:692-704. 2016
    ..previously suggested to regulate ghrelin secretion including adrenergic-β1 receptor, GPR81, oxytocin receptor, GPR120, and somatostatin receptor 2 were high in MGN3-1 cells...
  58. doi Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120
    Eva L Arantes
    Nursing School, University of Campinas, Campinas SP, Brazil
    Biol Res Nurs 18:411-9. 2016
    ..The topical use of polyunsaturated fatty acids (PUFAs) can accelerate skin wound healing through mechanisms that involve, at least in part, the modulation of inflammatory activity...
  59. pmc Eicosopentaneoic Acid and Other Free Fatty Acid Receptor Agonists Inhibit Lysophosphatidic Acid- and Epidermal Growth Factor-Induced Proliferation of Human Breast Cancer Cells
    Mandi M Hopkins
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, WA 99163, USA
    J Clin Med 5:. 2016
    ..by two G protein-coupled receptors (GPCRs) in the free fatty acid receptor (FFAR) family, FFA1 (GPR40) and FFA4 (GPR120). n-3 Fatty acids inhibit proliferation of human breast cancer cells in culture and in animals...
  60. doi Effect of dietary Schizochytrium microalga oil on selected markers of low-grade inflammation in rats
    T Komprda
    Department of Food Technology, Mendel University in Brno, Brno, Czech Republic
    J Anim Physiol Anim Nutr (Berl) 100:1169-1178. 2016
    ..of the genes coding for adiponectin receptors AdipoR1 and AdipoR2; no relationship to the expression of receptor GPR120 was found...
  61. pmc Long-chain unsaturated fatty acids reduce the transcriptional activity of the rat follicle-stimulating hormone β-subunit gene
    Ryutaro Moriyama
    Laboratory of Environmental Physiology, Department of Life Science, School of Science and Engineering, Kinki University, Osaka 577 8502, Japan
    J Reprod Dev 62:195-9. 2016
    ..agonist GW9508 on the transcription of the gonadotropin subunit genes Cga, Lhb and Fshb because LCFA receptor GPR120 was observed in mouse gonadotropes in our recent study...
  62. doi Developmental methylation pattern regulates porcine GPR120 expression
    H M Wang
    Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Ya an, Sichuan, China
    Genet Mol Res 15:. 2016
    ..It mostly occurs in CpG abundant regions, known as CpG islands (CGIs). G protein-coupled receptor 120 (GPR120) functions as an omega-3 fatty acid receptor and is involved in multiple-biological processes, including ..
  63. pmc Nutritional Signaling via Free Fatty Acid Receptors
    Junki Miyamoto
    Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183 0057, Japan
    Int J Mol Sci 17:450. 2016
    ..recent studies have shown that the administration of selective agonists of G protein-coupled receptor (GPR) 40 and GPR120 improved glucose metabolism and systemic metabolic disorders...
  64. doi Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells
    Kaori Fukushima
    Division of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3 4 1, Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biochem Biophys Res Commun 475:25-30. 2016
    G-protein-coupled receptor 120 (GPR120) and GPR40 exhibit a variety of biological responses by the binding of free fatty acids. 12-O-Tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis...
  65. ncbi The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120
    Francisca Rodriguez-Pacheco
    Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga Ibima, Hospital Regional Universitario, Malaga, Spain
    Eur J Nutr . 2016
    This study examines whether G-protein coupled receptor 120 (GPR120) is involved in the pro-/anti-inflammatory effects of different types of fatty acids (FAs) in human visceral adipocytes, and whether these effects may be altered in ..
  66. ncbi Anti-Inflammatory and Insulin-Sensitizing Effects of Free Fatty Acid Receptors
    Junki Miyamoto
    Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu shi, Tokyo, 183 0057, Japan
    Handb Exp Pharmacol . 2016
    ..FFARs are activated by specific FFAs; for example, GPR40 and GPR120 are activated by medium and long chain FFAs, GPR41 and GPR43 are activated by short chain FFAs, and GPR84 is ..
  67. pmc GPR120, a potential therapeutic target for experimental colitis in IL-10 deficient mice
    Jie Zhao
    Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China
    Oncotarget . 2016
    ..This study was aimed at figuring out whether DHA could ameliorate the Crohn's colitis by activating GPR120 and whether GPR120 could be a potential therapeutic target for CD...
  68. doi Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas
    Yufeng Zhao
    Department of Otolaryngology, Xijing Hospital, Fourth Military Medical University, Xi an, China
    Tissue Cell 45:421-7. 2013
    b>GPR120 functions as a plasma membrane receptor for unsaturated long-chain free fatty acids and involves in GLP-1 secretion, adipogenesis and the control of energy balance. Pancreas is the key organ in fuel and energy metabolism...
  69. pmc GPR40 and GPR120 fatty acid sensors are critical for postoral but not oral mediation of fat preferences in the mouse
    Anthony Sclafani
    Department of Psychology, Brooklyn College, City University of New York, Brooklyn, New York, and
    Am J Physiol Regul Integr Comp Physiol 305:R1490-7. 2013
    ..Here, we investigated the role of the fatty acid sensors GPR40 and GPR120 in postoral and oral preferences for a soybean oil emulsion (Intralipid)...
  70. doi GPR120 on Kupffer cells mediates hepatoprotective effects of ω3-fatty acids
    Dimitri Aristotle Raptis
    Department of Surgery, Laboratory of the Swiss HPB Center, University Hospital of Zurich, Switzerland
    J Hepatol 60:625-32. 2014
    ..Recently, GPR120 has been identified as a first receptor for ω3FAs, mediating their anti-inflammatory effects...
  71. doi Docosahexaenoic acid inhibits vascular endothelial growth factor (VEGF)-induced cell migration via the GPR120/PP2A/ERK1/2/eNOS signaling pathway in human umbilical vein endothelial cells
    Che Yi Chao
    Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan
    J Agric Food Chem 62:4152-8. 2014
    ..b>GPR120 is the putative receptor for DHA action...
  72. doi Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4
    Arndt Rohwedder
    Signalling Programme, Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    J Cell Sci 127:3104-15. 2014
    ..Here, we show that oleic acid stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-..
  73. doi Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120)
    Steven M Sparks
    Enteroendocrine Discovery Performance Unit, GlaxoSmithKline, PO Box 13398, Research Triangle Park, NC 27705, United States Electronic address
    Bioorg Med Chem Lett 24:3100-3. 2014
    The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39...
  74. doi Diet, metabolites, and "western-lifestyle" inflammatory diseases
    Alison N Thorburn
    Department of Immunology, Monash University, Clayton, VIC 3800, Australia
    Immunity 40:833-42. 2014
    ..metabolites engage "metabolite-sensing" G-protein-coupled receptors, such as GPR43, GPR41, GPR109A, GPR120, and GPR35...
  75. doi Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion
    Kanako Iwasaki
    Department of Diabetes, Endocrinology and Nutrition K Iw, N H, K Sa, S Y, K Su, A Ha, D N, K Sh, E J, T Har, N I, Graduate School of Medicine, and Department of Genomic Drug Discovery Science K Ii, A Hi, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606 8507, Japan and Faculty of Pharmaceutical Sciences T Has, Y A, Tokushima Bunri University, Tokushima 770 8514, Japan
    Endocrinology 156:837-46. 2015
    ..Among free fatty acid receptors, GPR120 was highly expressed in the K cells of the upper small intestine compared with the lower small intestine...
  76. doi Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice
    Barbara C Fam
    Department of Medicine Austin Health Austin Hospital, The University of Melbourne, Level 7, Lance Townsend Building, Studley Road, Heidelberg, Victoria 3084, Australia
    J Endocrinol 225:191-204. 2015
    ..ileum expression of G protein-coupled receptor (Gpr) 40 (Gpr40) was significantly increased, whereas Gpr120, Gpr119, Gpr41, and glucagon-like peptide 1 (Glp1) were reduced...
  77. ncbi Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives
    Robert Fredriksson
    Department of Neuroscience, Uppsala University, BMC, Box 593, 751 24 Uppsala, Sweden
    FEBS Lett 554:381-8. 2003
    ..human G protein-coupled receptors (GPCRs) found by searches in the human genome databases, termed GPR100, GPR119, GPR120, GPR135, GPR136, GPR141, and GPR142...
  78. pmc Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?
    Philip C Calder
    Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, MP887 Southampton General Hospital, Southampton, United Kingdom
    Br J Clin Pharmacol 75:645-62. 2013
    ..e. peroxisome proliferator activated receptor γ) and binding to the G protein coupled receptor GPR120. These mechanisms are interlinked...
  79. doi Assessment of the presence of chemosensing receptors based on bitter and fat taste in the gastrointestinal tract of young pig
    M Colombo
    University of Bologna, DIPROVAL, 42123 Reggio Emilia, Italy
    J Anim Sci 90:128-30. 2012
    ..TAS2R1, TAS2R3, TAS2R7, TAS2R9, TAS2R10, TAS2R16, and TAS2R38) and for 3 genes for fat taste (GPR40, GPR43, and GPR120), a full homology for exon sequences was found and primers were designed by Primer3...
  80. ncbi [Diet-induced obesity and GPR120]
    Atsuhiko Ichimura
    Division of Molecular Medicine and Therapy, United Centers for Advanced Research and Translational Medicine ART, Tohoku University Graduate School of Medicine
    Nihon Rinsho 71:350-4. 2013
    Free fatty acids (FFAs) have been demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs). GPR120 is activated by unsaturated long-chain FFAs and has a crucial role in various physiological homeostasis mechanisms ..
  81. doi In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469
    C Urban
    Pharmaceutical and Medicinal Chemistry, Heinrich Heine University, Universitatsstr 1, 40225, Dusseldorf, Germany
    Naunyn Schmiedebergs Arch Pharmacol 386:1021-30. 2013
    ..of TUG-469 was studied using Ca(2+)-, cAMP-, and impedance-based assays at recombinant FFA1 and free fatty acid receptor 4, formerly known as GPR120 (FFA4) expressing 1321N1 cells and the rat insulinoma cell line INS-1...
  82. doi Antiobese effects of capsaicin-chitosan microsphere (CCMS) in obese rats induced by high fat diet
    Sirong Tan
    Key Research Center of Liver Regulation for Hyperlipemia SATCM Class III Laboratory of Metabolism SATCM, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou 510006, China
    J Agric Food Chem 62:1866-74. 2014
    ..The mRNA expression of PPARα, PPARγ, leptin, UCP2, GPR120, FTO, and adiponectin in the liver was determined by quantitative real-time PCR, and the protein expression of ..
  83. pmc Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease
    Valerio Nobili
    Unit of Liver Research, Bambino Gesu Children s Hospital, Rome, Italy
    PLoS ONE 9:e88005. 2014
    ..Our aim was to investigate in pediatric NAFLD the mechanisms underlying the effects of DHA administration on histo-pathological aspects, GPR120 expression, hepatic progenitor cell activation and macrophage pool.
  84. pmc GPR120 (FFAR4) is preferentially expressed in pancreatic delta cells and regulates somatostatin secretion from murine islets of Langerhans
    Virginia M Stone
    Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, RILD Building, Barrack Road, Exeter, EX2 5DW, UK
    Diabetologia 57:1182-91. 2014
    The NEFA-responsive G-protein coupled receptor 120 (GPR120) has been implicated in the regulation of inflammation, in the control of incretin secretion and as a predisposing factor influencing the development of type 2 diabetes by ..
  85. pmc Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons
    Leigh Wellhauser
    Department of Physiology, Faculty of Medicine, University of Toronto, 1 King s College Circle, Medical Sciences Building 3344, Toronto, Ontario M5S 1A8, Canada
    J Neuroinflammation 11:60. 2014
    ..At least in the periphery, omega-3 fatty acids and their receptor, G-protein coupled receptor 120 (GPR120), have emerged as putative targets. The role for GPR120 in the hypothalamus or CNS in general is poorly understood.
  86. pmc Obstructive sleep apnea and obesity are associated with reduced GPR 120 plasma levels in children
    David Gozal
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL
    Sleep 37:935-41. 2014
    ..We hypothesized that GPR 120 levels would be reduced in children with OSA, particularly among obese children...
  87. pmc Expression and localization of the omega-3 fatty acid receptor GPR120 in human term placenta
    S Lager
    Center for Pregnancy and Newborn Research, Department of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, TX, USA Electronic address
    Placenta 35:523-5. 2014
    ..b>GPR120 dysfunction is associated with obesity in humans...
  88. pmc Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagy
    Yolanda Williams-Bey
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 9:e97957. 2014
    ..The inhibition required Free Fatty Acid Receptor (FFAR) 4 (also known as GPR120), a G-protein coupled receptor (GPR) known to bind DHA...
  89. doi Evaluation of the insulin-releasing and glucose-lowering effects of GPR120 activation in pancreatic β-cells
    B M Moran
    Biomedical Sciences Research Institute, SAAD Centre for Pharmacy and Diabetes, University of Ulster, Coleraine, UK
    Diabetes Obes Metab 16:1128-39. 2014
    To assess the potency and selectivity of various GPR120 agonists and to determine the cellular localization of GPR120 in clonal β-cells and pancreatic islets.
  90. doi Role of free fatty acid receptors in the regulation of energy metabolism
    Takafumi Hara
    Department of Pharmacogenomics, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida Shimoadachi cho, Sakyo ku, Kyoto 606 8501, Japan Electronic address
    Biochim Biophys Acta 1841:1292-300. 2014
    ..Medium- and long-chain FFAs activate FFA1/GPR40 and FFA4/GPR120. Short-chain FFAs activate FFA2/GPR43 and FFA3/GPR41...
  91. doi CD36, but not GPR120, is required for efficient fatty acid utilization during endurance exercise
    Mina Fujitani
    a Laboratory of Nutrition Chemistry, Graduate School of Agriculture, Kyoto University, Sakyou ku, Japan
    Biosci Biotechnol Biochem 78:1871-8. 2014
    ..FA translocase/cluster of differentiation 36 (CD36) and G protein-coupled receptor GPR120 are long-chain FA receptors...
  92. doi Expression of the long-chain fatty acid receptor GPR120 in the gonadotropes of the mouse anterior pituitary gland
    Ryutaro Moriyama
    Laboratory of Molecular Neurobiology, Department of Life Science, Kinki University, 3 4 1 Kowakae, Higashiosaka, Osaka, 577 8502, Japan
    Histochem Cell Biol 143:21-7. 2015
    G-protein-coupled receptor 120 (GPR120) has been known to be a receptor of long-chain fatty acids. Here, we investigated GPR120 expression in the mouse pituitary gland via real-time PCR, in situ hybridization, and immunohistochemistry...
  93. doi Next generation semiconductor based-sequencing of a nutrigenetics target gene (GPR120) and association with growth rate in Italian Large White pigs
    Luca Fontanesi
    a Department of Agricultural and Food Sciences DISTAL, Division of Animal Sciences, University of Bologna, Bologna, Italy
    Anim Biotechnol 26:92-7. 2015
    The GPR120 gene (also known as FFAR4 or O3FAR1) encodes for a functional omega-3 fatty acid receptor/sensor that mediates potent insulin sensitizing effects by repressing macrophage-induced tissue inflammation...
  94. doi Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells
    Shuhei Ishii
    Division of Cancer Biology and Bioinformatics, Department of Life Science, Faculty of Science and Engineering, Kinki University, 3 4 1, Kowakae, Higashiosaka, Osaka 577 8502, Japan
    Biochem Biophys Res Commun 456:135-8. 2015
    ..G-protein-coupled receptor 120 (GPR120) and GPR40 are activated by long and medium chain FFAs...
  95. pmc The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice
    Déborah Ancel
    NUTOX, UMR U866 INSERM Université de Bourgogne AgroSup Dijon, F21000 Dijon, France
    J Lipid Res 56:369-78. 2015
    Implication of the long-chain fatty acid (LCFA) receptor GPR120, also termed free fatty acid receptor 4, in the taste-guided preference for lipids is a matter of debate...
  96. pmc Omega-3 fatty acids and other FFA4 agonists inhibit growth factor signaling in human prostate cancer cells
    Ze Liu
    Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington
    J Pharmacol Exp Ther 352:380-94. 2015
    ..G protein-coupled receptors (GPCRs) of the free fatty acid receptor (FFAR) family, FFA1/GPR40 and FFA4/GPR120, specifically bind n-3 FAs as agonist ligands...
  97. pmc Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis
    Yasunori Konno
    Department of General Internal Medicine and Clinical Laboratory Medicine, Akita University Graduate School of Medicine, Akita, Japan
    PLoS ONE 10:e0120386. 2015
    ..b>GPR120 (FFA4) is a G protein-coupled receptor (GPCR) for long-chain fatty acids that functions as a regulator of ..
  98. doi G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro
    Zhi Gong
    Area of Regulatory Biology, Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo ohkubo, Sakuraku, Saitama, Japan
    Am J Physiol Endocrinol Metab 306:E28-35. 2014
    ..cell lines and found that these cells express high levels of mRNA encoding G-protein coupled receptor 120 (GPR120)...
  99. ncbi Monitoring ligand-mediated internalization of G protein-coupled receptor as a novel pharmacological approach
    Shin ichi Fukunaga
    Department of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida shimo adachi cho, Sakyo ku, Kyoto 606 8501, Japan
    Life Sci 80:17-23. 2006
    ..monitored the internalization of the proton-sensing GPCR TDAG8, and that of the free fatty acid-sensitive GPCR GPR120. The results show that monitoring receptor internalization can be a useful approach for pharmacological ..
  100. pmc Altered expression of gustatory-signaling elements in gastric tissue of morbidly obese patients
    P Widmayer
    Institute of Physiology, University of Hohenheim, Stuttgart, Germany
    Int J Obes (Lond) 36:1353-9. 2012
    ....
  101. doi Nutrient sensing and signalling by the gut
    Rojo Rasoamanana
    AgroParisTech, CRNH IdF, UMR914 Nutrition Physiology and Ingestive Behavior, F 75005 Paris, France
    Proc Nutr Soc 71:446-55. 2012
    ..such as T1R1/T1R3 heterodimer, Ca sensing receptor and GPR93 for amino acids and protein, GPR40, GPR41, GPR43 and GPR120 for fatty acids, T1R2/T1R3 heterodimer for monosaccharides) are expressed in the apical face of the gut and sense ..

Research Grants7

  1. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..Towards this end, the proposed studies capitalize on our new finding that GPR120, a lipid sensing GPCR expressed in proinflammatory macro- phages, functions as the omega 3 fatty acid receptor...
  2. The role of phosphorylation in regulating the antidiabetic effects of O3FAR-1
    Nader H Moniri; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The omega-3 fatty acid receptor (O3FAR1), also commonly referred to as GPR120, is a G protein-coupled receptor (GPCR) that has been shown to be agonized by long chained unsaturated fatty acids, ..
  3. Rachana Shah; Fiscal Year: 2015
    ..Recently a LC n-3 PUFA receptor, GPR120, has been identified that in mouse and cell models appears to modulate n-3 PUFA inhibition of nuclear factor kappa ..
  4. Ruth E Patterson; Fiscal Year: 2015
    ..of omega 3 fatty acids will reduce breast tumor growth and metastasis and whether the w3 fatty acid receptor GPR120 is the critical mediator of those cancer-protective effects...
  5. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
    ..the anti-inflammatory effects of omega-3 FAs involves the binding of a G-protein coupled receptor 120 (GPR120) with resultant inhibition of TNF-a and lipopolysaccharide-mediated inflammatory cascades...
  6. W SUE RITTER; Fiscal Year: 2016
    ..control, may also have fatty acid receptor blocking effects at G-protein coupled receptors (GPR40 and/or GPR120) that are independent of fat oxidation...