FFAR4

Summary

Gene Symbol: FFAR4
Description: free fatty acid receptor 4
Alias: BMIQ10, GPR120, GPR129, GT01, O3FAR1, PGR4, free fatty acid receptor 4, G-protein coupled receptor 120, G-protein coupled receptor 129, G-protein coupled receptor GT01, G-protein coupled receptor PGR4, omega-3 fatty acid receptor 1
Species: human
Products:     FFAR4

Top Publications

  1. Oh D, Talukdar S, Bae E, Imamura T, Morinaga H, Fan W, et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010;142:687-98 pubmed publisher
    ..Here, we show that the G protein-coupled receptor 120 (GPR120) functions as an omega-3 FA receptor/sensor...
  2. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, et al. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med. 2005;11:90-4 pubmed
    ..Here we show that a G-protein-coupled receptor, GPR120, which is abundantly expressed in intestine, functions as a receptor for unsaturated long-chain FFAs...
  3. Ozdener M, Subramaniam S, Sundaresan S, Sery O, Hashimoto T, Asakawa Y, et al. CD36- and GPR120-mediated Ca²? signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Gastroenterology. 2014;146:995-1005 pubmed publisher
    ..We studied the roles of the fat taste receptors CD36 and GPR120 and their interactions via Ca(2+) signaling in fungiform taste bud cells (TBC)...
  4. Watson S, Brown A, Holliday N. Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol. 2012;81:631-42 pubmed publisher
    b>GPR120 is a long-chain fatty acid receptor that stimulates incretin hormone release from colonic endocrine cells and is implicated in macrophage and adipocyte function...
  5. Waguri T, Goda T, Kasezawa N, Yamakawa Kobayashi K. The combined effects of genetic variations in the GPR120 gene and dietary fat intake on obesity risk. Biomed Res. 2013;34:69-74 pubmed
    ..3 polyunsaturated fatty acids (PUFA) have anti-inflammatory effects, and the G protein-coupled receptor GPR120 was reported to mediate the anti-inflammatory effects of ?-3 PUFAs...
  6. Burns R, Singh M, Senatorov I, Moniri N. Mechanisms of homologous and heterologous phosphorylation of FFA receptor 4 (GPR120): GRK6 and PKC mediate phosphorylation of Thr³??, Ser³??, and Ser³?? in the C-terminal tail. Biochem Pharmacol. 2014;87:650-9 pubmed publisher
    b>Free fatty acid receptor 4 (FFA4), previously known as GPR120, is a G protein-coupled receptor that promotes numerous anti-inflammatory and antidiabetic effects upon its agonism by long chained unsaturated fatty acids...
  7. Butcher A, Hudson B, Shimpukade B, Alvarez Curto E, Prihandoko R, Ulven T, et al. Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4. J Biol Chem. 2014;289:18451-65 pubmed publisher
    ..Among these is FFA4, previously called GPR120, which responds to medium and long chain fatty acids, including health-promoting ?-3 fatty acids, which have been ..
  8. Moore K, Zhang Q, Murgolo N, Hosted T, Duffy R. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: comparison with human GPR120 splice variants. Comp Biochem Physiol B Biochem Mol Biol. 2009;154:419-26 pubmed publisher
    Activation of the GPCR GPR120 by free fatty acids has been reported to cause GLP-1 release in rodent intestine. One genetic sequence was reported for rodents, while two sequences were reported for human GPR120, BC101175 and NM_181745...
  9. Burns R, Moniri N. Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun. 2010;396:1030-5 pubmed publisher
    The newly discovered G protein-coupled receptor GPR120 has recently been shown to stimulate secretion of the gut hormones glucagon-like peptide-1 and cholecystokinin upon binding of free fatty acids, thrusting it to the forefront of drug ..

More Information

Publications77

  1. Ichimura A, Hirasawa A, Poulain Godefroy O, Bonnefond A, Hara T, Yengo L, et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012;483:350-4 pubmed publisher
    ..b>GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role ..
  2. Sanchez Reyes O, Romero Avila M, Castillo Badillo J, Takei Y, Hirasawa A, Tsujimoto G, et al. Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. Eur J Pharmacol. 2014;723:368-74 pubmed publisher
    GPR120, free fatty acid receptor 4, is a recently deorphanized G protein-coupled receptor that seems to play cardinal roles in the regulation of metabolism and in the pathophysiology of inflammatory and metabolic disorders...
  3. Ichimura A, Hirasawa A, Hara T, Tsujimoto G. Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis. Prostaglandins Other Lipid Mediat. 2009;89:82-8 pubmed publisher
    ..demonstrated to act as ligands of several G-protein-coupled receptors (GPCRs) (FFAR1, FFAR2, FFAR3, GPR84, and GPR120)...
  4. Galindo M, Voigt N, Stein J, van Lengerich J, Raguse J, Hofmann T, et al. G protein-coupled receptors in human fat taste perception. Chem Senses. 2012;37:123-39 pubmed publisher
    ..We demonstrated that the pharmacological activation profile of human GPR40 and GPR120, 2 LCFA-specific receptors associated with gustatory fat perception in rodents, is inconsistent with the "..
  5. Wu Q, Wang H, Zhao X, Shi Y, Jin M, Wan B, et al. Identification of G-protein-coupled receptor 120 as a tumor-promoting receptor that induces angiogenesis and migration in human colorectal carcinoma. Oncogene. 2013;32:5541-50 pubmed publisher
    G-protein-coupled receptor 120 (GPR120) functions as a receptor for unsaturated long-chain free fatty acids and has an important role in regulating lipid and glucose metabolism...
  6. Cai X, Hayashi S, Fang C, Hao S, Wang X, Nishiguchi S, et al. Pu'erh tea extract-mediated protection against hepatosteatosis and insulin resistance in mice with diet-induced obesity is associated with the induction of de novo lipogenesis in visceral adipose tissue. J Gastroenterol. 2017;52:1240-1251 pubmed publisher
    ..PTE inhibited VAT inflammation by simultaneously downregulating inflammatory molecules and inducing expression of Gpr120 that encodes an anti-inflammatory and pro-adipogenesis receptor (GPR-120) that recognizes unsaturated long-chain ..
  7. Lee J, Moraes Vieira P, Castoldi A, Aryal P, Yee E, Vickers C, et al. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016;291:22207-22217 pubmed
    ..appearance), and augmented intestinal crypt Paneth cell bactericidal potency via a mechanism that may involve GPR120. In vitro, PAHSAs attenuated dendritic cell activation and subsequent T cell proliferation and Th1 polarization...
  8. Calder P. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. Biochim Biophys Acta. 2015;1851:469-84 pubmed publisher
    ..transcription factor peroxisome proliferator activated receptor γ and binding to the G protein coupled receptor GPR120. These mechanisms are interlinked, although the full extent of this is not yet elucidated...
  9. Murase R, Sato H, Yamamoto K, Ushida A, Nishito Y, Ikeda K, et al. Group X Secreted Phospholipase A2 Releases ω3 Polyunsaturated Fatty Acids, Suppresses Colitis, and Promotes Sperm Fertility. J Biol Chem. 2016;291:6895-911 pubmed publisher
    ..and ω3 PUFAs attenuated their production by lamina propria cells partly through the fatty acid receptor GPR120. In comparison, cytosolic phospholipase A2(cPLA2α) protects from colitis by mobilizing ω6 arachidonic acid ..
  10. Fam B, Sgambellone R, Ruan Z, Proietto J, Andrikopoulos S. Contribution of the hypothalamus and gut to weight gain susceptibility and resistance in mice. J Endocrinol. 2015;225:191-204 pubmed publisher
    ..ileum expression of G protein-coupled receptor (Gpr) 40 (Gpr40) was significantly increased, whereas Gpr120, Gpr119, Gpr41, and glucagon-like peptide 1 (Glp1) were reduced...
  11. Alarcon P, Manosalva C, Carretta M, Hidalgo A, Figueroa C, Taubert A, et al. Fatty and hydroxycarboxylic acid receptors: The missing link of immune response and metabolism in cattle. Vet Immunol Immunopathol. 2018;201:77-87 pubmed publisher
    ..activation of specific G protein-coupled receptors, including GPR41/FFA3 and GPR43/FFA2 for SCFA; GPR40/FFA1 and GPR120/FFA4 for LCFA, GPR109A/HCA2 for ketone body ?-hydroxybutyrate, and GPR81/HCA1 for lactate, all ..
  12. Nakamura K, Miura D, Saito Y, Yunoki K, Koyama Y, Satoh M, et al. Eicosapentaenoic acid prevents arterial calcification in klotho mutant mice. PLoS ONE. 2017;12:e0181009 pubmed publisher
    ..EPA decreased expression levels of the NOX4 gene and NOX activity. GPR120, a receptor of n-3 fatty acids, gene knockdown by siRNA canceled effects of EPA on NOX4 gene expression and NOX ..
  13. Kain V, Liu F, Kozlovskaya V, Ingle K, Bolisetty S, Agarwal A, et al. Resolution Agonist 15-epi-Lipoxin A4 Programs Early Activation of Resolving Phase in Post-Myocardial Infarction Healing. Sci Rep. 2017;7:9999 pubmed publisher
    ..15-epi-LXA4 activated formyl peptide receptor (FPR2) and GPR120 on alternative macrophages but inhibited GPR40 on classical macrophages in-vitro...
  14. Diaz M, García C, Sebastiani G, de Zegher F, Lopez Bermejo A, Ibanez L. Placental and Cord Blood Methylation of Genes Involved in Energy Homeostasis: Association With Fetal Growth and Neonatal Body Composition. Diabetes. 2017;66:779-784 pubmed publisher
    ..and function, and lipid metabolism) were hypermethylated in placenta and cord blood from SGA newborns, whereas GPR120 (related to free fatty acid regulation) was hypomethylated in placenta and hypermethylated in cord blood...
  15. Sundaresan S, Abumrad N. Dietary Lipids Inform the Gut and Brain about Meal Arrival via CD36-Mediated Signal Transduction. J Nutr. 2015;145:2195-200 pubmed publisher
    ..by these receptors are the long-chain fatty acids that act as ligands for 2 G protein-coupled receptors, GPR40 and GPR120, and the fatty acid (FA) translocase/CD36...
  16. Park S, Herrnreiter A, Pfister S, Gauthier K, Falck B, Falck J, et al. GPR40 is a low-affinity epoxyeicosatrienoic acid receptor in vascular cells. J Biol Chem. 2018;293:10675-10691 pubmed publisher
    ..EETs are weak GPR120 agonists...
  17. Wang M, Zhang X, Ma L, Feng R, Yan C, Su H, et al. Omega-3 polyunsaturated fatty acids ameliorate ethanol-induced adipose hyperlipolysis: A mechanism for hepatoprotective effect against alcoholic liver disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:3190-3201 pubmed publisher
    ..by increasing PDE3B activity and reducing cAMP accumulation in adipocyte, which was associated with activation of GPR120 and regulation of Ca2+/CaMKK?/AMPK signaling, resultantly blocking fatty acid trafficking from adipose ..
  18. Richards P, Pais R, Habib A, Brighton C, Yeo G, Reimann F, et al. High fat diet impairs the function of glucagon-like peptide-1 producing L-cells. Peptides. 2016;77:21-7 pubmed publisher
    ..processing enzymes (Pcsk1, Cpe), granins (Chgb, Scg2), nutrient sensing machinery (Slc5a1, Slc15a1, Abcc8, Gpr120) and enteroendocrine-specific transcription factors (Etv1, Isl1, Mlxipl, Nkx2.2 and Rfx6)...
  19. Yore M, Syed I, Moraes Vieira P, Zhang T, Herman M, Homan E, et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014;159:318-32 pubmed publisher
    ..PAHSAs also reduce adipose tissue inflammation. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake...
  20. Bae I, Park P, Lee J, Cho E, Lee T, Kim S. PPAR?-mediated G-protein coupled receptor 120 signaling pathway promotes transcriptional activation of miR-143 in adipocytes. Gene. 2017;626:64-69 pubmed publisher
    ..b>GPR120 silencing in adipocytes inhibited the expression of PPAR? and miR-143, whereas GPR120 overexpression led to ..
  21. Wang F, Yang Q, Huesman S, Xu M, Li X, Lou D, et al. The role of apolipoprotein A-IV in regulating glucagon-like peptide-1 secretion. Am J Physiol Gastrointest Liver Physiol. 2015;309:G680-7 pubmed publisher
    ..gene expression of GLUT-2 and the lipid receptors, including G protein-coupled receptor (GPR) 40, GPR119, and GPR120 in intestinal segments. GLUT-2, GPR40 and GPR120 mRNAs were unaltered by apoA-IV knockout...
  22. Han L, Lei H, Tian Z, Wang X, Cheng D, Wang C. The immunomodulatory activity and mechanism of docosahexenoic acid (DHA) on immunosuppressive mice models. Food Funct. 2018;: pubmed publisher
    ..In addition, DHA could activate macrophages by the G-protein coupled cell membrane receptor GPR120- Mitogen-Activated Protein Kinases (MAPKs)-nuclear factor ?B (NF-?B) p65 pathway in vivo...
  23. Onodera T, Fukuhara A, Shin J, Hayakawa T, Otsuki M, Shimomura I. Eicosapentaenoic acid and 5-HEPE enhance macrophage-mediated Treg induction in mice. Sci Rep. 2017;7:4560 pubmed publisher
    ..Among EPA metabolites, 5-HEPE was the most potent inducer of Tregs. GPR119 and GPR120 are receptors for 5-HEPE and EPA, respectively, and antagonist of GPR119 blocked Treg induction by EPA in the ..
  24. Brissard L, Leemput J, Hichami A, Passilly Degrace P, Maquart G, Demizieux L, et al. Orosensory Detection of Dietary Fatty Acids Is Altered in CB?R-/- Mice. Nutrients. 2018;10: pubmed publisher
    ..No difference in CD36 and GPR120 protein expressions were observed in taste bud cells (TBC) from WT and CB?R-/- mice...
  25. Miyamoto J, Hasegawa S, Kasubuchi M, Ichimura A, Nakajima A, Kimura I. Nutritional Signaling via Free Fatty Acid Receptors. Int J Mol Sci. 2016;17:450 pubmed publisher
    ..recent studies have shown that the administration of selective agonists of G protein-coupled receptor (GPR) 40 and GPR120 improved glucose metabolism and systemic metabolic disorders...
  26. Dramane G, Akpona S, Simonin A, Besnard P, Khan N. Cell signaling mechanisms of gustatory perception of lipids: can the taste cells be the target of anti-obesity agents?. Curr Med Chem. 2011;18:3417-22 pubmed
    ..It has been recently shown that these receptors particularly GPR40 and GPR120 might also be involved in lipid taste perception...
  27. Furutani A, Ikeda Y, Itokawa M, Nagahama H, Ohtsu T, Furutani N, et al. Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120. PLoS ONE. 2015;10:e0132472 pubmed publisher
    ..In this model, insulin depletion blocked the effect of tuna oil and fish oil had no effect on mice deficient for GPR120, a polyunsaturated fatty acid receptor...
  28. Hudson B, Shimpukade B, Milligan G, Ulven T. The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120). J Biol Chem. 2014;289:20345-58 pubmed publisher
    The long-chain fatty acid receptor FFA4 (previously GPR120) is receiving substantial interest as a novel target for the treatment of metabolic and inflammatory disease...
  29. Rohwedder A, Zhang Q, Rudge S, Wakelam M. Lipid droplet formation in response to oleic acid in Huh-7 cells is mediated by the fatty acid receptor FFAR4. J Cell Sci. 2014;127:3104-15 pubmed publisher
    ..Here, we show that oleic acid stimulates lipid droplet formation by activating the long-chain fatty acid receptor FFAR4, which signals through a pertussis-toxin-sensitive G-protein signalling pathway involving phosphoinositide 3-..
  30. Konno Y, Ueki S, Takeda M, Kobayashi Y, Tamaki M, Moritoki Y, et al. Functional analysis of free fatty acid receptor GPR120 in human eosinophils: implications in metabolic homeostasis. PLoS ONE. 2015;10:e0120386 pubmed publisher
    ..b>GPR120 (FFA4) is a G protein-coupled receptor (GPCR) for long-chain fatty acids that functions as a regulator of ..
  31. Zhang X, Cai C, Winters M, Wells M, Wall M, Lanter J, et al. Design, synthesis and SAR of a novel series of heterocyclic phenylpropanoic acids as GPR120 agonists. Bioorg Med Chem Lett. 2017;27:3272-3278 pubmed publisher
    A novel series of 5-membered heterocycle-containing phenylpropanoic acid derivatives was discovered as potent GPR120 agonists with low clearance, high oral bioavailability and in vivo antidiabetic activity in rodents.
  32. Kim J, Lee K, Park S, Kang S, Huang J, Lee J, et al. Omega-3 fatty acids induce Ca(2+) mobilization responses in human colon epithelial cell lines endogenously expressing FFA4. Acta Pharmacol Sin. 2015;36:813-20 pubmed publisher
    b>Free fatty acid receptor 4 (FFA4; formerly known as GPR120) is the G protein-coupled receptor (GPCR) for omega-3 polyunsaturated fatty acids. FFA4 has been found to express in the small intestines and colons of mice and humans...
  33. Hansen S, Ulven T. Pharmacological Tool Compounds for the Free Fatty Acid Receptor 4 (FFA4/GPR120). Handb Exp Pharmacol. 2017;236:33-56 pubmed publisher
    The free fatty acid receptor 4 (FFA4), also known as GPR120, is a G protein-coupled receptor that is activated by long-chain fatty acids and that has been associated with regulation of appetite, release of insulin controlling hormones, ..
  34. Li A, Li Y, Du L. Biological characteristics and agonists of GPR120 (FFAR4) receptor: the present status of research. Future Med Chem. 2015;7:1457-68 pubmed publisher
    b>GPR120 receptor functions as a receptor for ω-3 fatty acid, involving regulating the secretion of gastrointestinal peptide hormone, adipogenesis, adipogenic differentiation and anti-inflammatory process and the like in the aspect of ..
  35. Ahn S, Park S, Baek J, Lee S, Baek W, Lee S, et al. Free Fatty Acid Receptor 4 (GPR120) Stimulates Bone Formation and Suppresses Bone Resorption in the Presence of Elevated n-3 Fatty Acid Levels. Endocrinology. 2016;157:2621-35 pubmed publisher
    b>Free fatty acid receptor 4 (FFA4) has been reported to be a receptor for n-3 fatty acids (FAs). Although n-3 FAs are beneficial for bone health, a role of FFA4 in bone metabolism has been rarely investigated...
  36. Zhao N, Wang L, Guo N. α-Linolenic acid increases the G0/G1 switch gene 2 mRNA expression in peripheral blood mononuclear cells from obese patients: a pilot study. Lipids Health Dis. 2016;15:36 pubmed publisher
    ..expression levels of proliferator-activated receptor gamma (PPAR-γ), G0S2, and G protein-coupled receptor 120 (GPR120) in PBMC were repeatedly examined from fasting obese patients before and after ALA treatment...
  37. Tanagho P, Shohdy K. GPR 120: The Potential Target for Obesity Treatment. Endocr Metab Immune Disord Drug Targets. 2016;16:8-11 pubmed
    b>G protein coupled receptor 120 (GPR120) is a class of receptors in the gastrointestinal tract (GIT) that is implicated in nutrient sensing and body weight regulation...
  38. Anbazhagan A, Priyamvada S, Gujral T, Bhattacharyya S, Alrefai W, Dudeja P, et al. A novel anti-inflammatory role of GPR120 in intestinal epithelial cells. Am J Physiol Cell Physiol. 2016;310:C612-21 pubmed publisher
    b>GPR120 (free fatty acid receptor-4) is a G protein-coupled receptor for medium- and long-chain unsaturated fatty acids, including ω-3 fatty acids...
  39. Suckow A, Polidori D, Yan W, Chon S, Ma J, Leonard J, et al. Alteration of the glucagon axis in GPR120 (FFAR4) knockout mice: a role for GPR120 in glucagon secretion. J Biol Chem. 2014;289:15751-63 pubmed publisher
    GPR40 (FFAR1) and GPR120 (FFAR4) are G-protein-coupled receptors (GPCRs) that are activated by long chain fatty acids (LCFAs)...
  40. Ekberg J, Hauge M, Kristensen L, Madsen A, Engelstoft M, Husted A, et al. GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40). Endocrinology. 2016;157:4561-4569 pubmed
    ..of incretin secretion; however, the relative importance of FFA1 (G Protein-coupled Receptor [GPR] 40), FFA4 (GPR120), and GPR119, which all recognize TG metabolites, ie, long-chain fatty acid and 2-monoacylglycerol, respectively, ..
  41. Ishii S, Kitamura Y, Hirane M, Tomimatsu A, Fukushima K, Takahashi K, et al. Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells. Mol Carcinog. 2016;55:1553-1559 pubmed publisher
    G-protein-coupled receptor 40 (GPR40) and GPR120 mediate a variety of biological functions by the binding of long and medium chain free fatty acids...
  42. Lombardo M, Bender K, London C, Plotkin M, Kirkland M, Mane J, et al. Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects. Bioorg Med Chem Lett. 2016;26:5724-5728 pubmed publisher
    ..ultra high-throughput screening (uHTS) hit into a potent and selective series of G-protein coupled receptor 120 (GPR120) agonists is reported...
  43. Takahashi K, Fukushima K, Onishi Y, Node Y, Inui K, Fukushima N, et al. Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells. Biochem Biophys Res Commun. 2017;484:675-680 pubmed publisher
    G-protein-coupled receptor 120 (GPR120) and GPR40 are members of free fatty acid (FFA) receptors and mediate a variety of biological responses through binding of medium- and long-chain FFAs...
  44. Hasan A, Ohmori K, Hashimoto T, Kamitori K, Yamaguchi F, Noma T, et al. GPR120 in adipocytes has differential roles in the production of pro-inflammatory adipocytokines. Biochem Biophys Res Commun. 2017;486:76-82 pubmed publisher
    ..Here, we evaluated the effects of ?-3 polyunsaturated fatty acid specific G-protein coupled receptor 120 (GPR120) activation on inflammatory pathways in adipocytes, and the influence of this process on macrophage migration...
  45. Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T. Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells. Biochem Biophys Res Commun. 2016;475:25-30 pubmed publisher
    G-protein-coupled receptor 120 (GPR120) and GPR40 exhibit a variety of biological responses by the binding of free fatty acids. 12-O-Tetradecanoylphorbol-13-acetate (TPA) is a tumor promoting agent of skin carcinogenesis...
  46. Auguste S, Fisette A, Fernandes M, Hryhorczuk C, Poitout V, Alquier T, et al. Central Agonism of GPR120 Acutely Inhibits Food Intake and Food Reward and Chronically Suppresses Anxiety-Like Behavior in Mice. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    b>GPR120 (FFAR4) is a G-protein coupled receptor implicated in the development of obesity and the antiinflammatory and insulin-sensitizing effects of omega-3 (ω-3) polyunsaturated fatty acids...
  47. Chen K, Zhou J, Zhang F, Zhang F, Zhang R, Zhan M, et al. Transcription factor C/EBPβ promotes the transcription of the porcine GPR120 gene. J Mol Endocrinol. 2016;56:91-100 pubmed publisher
    G protein-coupled receptor 120 (GPR120), an adipogenic receptor critical for the differentiation and maturation of adipocytes, plays an important role in controlling obesity in both humans and rodents and, thus, is an attractive target of ..
  48. Meng Y, Yuan C, Zhang J, Zhang F, Fu Q, Zhu X, et al. Stearic acid suppresses mammary gland development by inhibiting PI3K/Akt signaling pathway through GPR120 in pubertal mice. Biochem Biophys Res Commun. 2017;491:192-197 pubmed publisher
    ..Furthermore, dietary SA led to increase of G protein-coupled receptor 120 (GPR120) expression and inhibition of PI3K/Akt signaling pathway in mammary gland of pubertal mice...
  49. Bonnefond A, Lamri A, Leloire A, Vaillant E, Roussel R, Lévy Marchal C, et al. Contribution of the low-frequency, loss-of-function p.R270H mutation in FFAR4 (GPR120) to increased fasting plasma glucose levels. J Med Genet. 2015;52:595-8 pubmed publisher
    We previously reported that the low-frequency, loss-of-function variant p.R270H in FFAR4 encoding the lipid sensor GPR120 was associated with obesity...
  50. Moniri N. Free-fatty acid receptor-4 (GPR120): Cellular and molecular function and its role in metabolic disorders. Biochem Pharmacol. 2016;110-111:1-15 pubmed publisher
    ..In addition, recent endeavors toward discovery of small molecules that modulate FFA4 activity are also presented. ..
  51. Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, et al. Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2015;309:L970-82 pubmed publisher
    ..and long-chain free fatty acids act as endogenous ligands for the free fatty acid receptors FFAR1/GPR40 and FFAR4/GPR120, which couple to Gq proteins...
  52. Arantes E, Dragano N, Ramalho A, Vitorino D, de Souza G, Lima M, et al. Topical Docosahexaenoic Acid (DHA) Accelerates Skin Wound Healing in Rats and Activates GPR120. Biol Res Nurs. 2016;18:411-9 pubmed publisher
    ..We evaluated whether G-protein-coupled receptor 120 (GPR120), a recently identified receptor for docosahexaenoic acid (DHA) with anti-inflammatory activity, is expressed in ..
  53. Milligan G, Alvarez Curto E, Hudson B, Prihandoko R, Tobin A. FFA4/GPR120: Pharmacology and Therapeutic Opportunities. Trends Pharmacol Sci. 2017;38:809-821 pubmed publisher
    b>Free Fatty Acid receptor 4 (FFA4), also known as GPR120, is a G-protein-coupled receptor (GPCR) responsive to long-chain fatty acids that is attracting considerable attention as a potential novel therapeutic target for the treatment of ..
  54. Zhang D, Leung P. Potential roles of GPR120 and its agonists in the management of diabetes. Drug Des Devel Ther. 2014;8:1013-27 pubmed publisher
    ..FFAR4 is also known as G-protein coupled receptor 120 (GPR120). The main role of GPR120 is to elicit FFA regulation on metabolism homeostasis...
  55. Rodriguez Pacheco F, Garcia Serrano S, Garcia Escobar E, Gutierrez Repiso C, Garcia Arnes J, Valdes S, et al. Effects of obesity/fatty acids on the expression of GPR120. Mol Nutr Food Res. 2014;58:1852-60 pubmed publisher
    The effects that fatty acids (FAs) exert on G protein-coupled receptor-120 (GPR120) levels, a receptor for FAs, are still unknown. We analyzed the association between GPR120 and obesity, and the FA effects on its expression...
  56. Kita T, Kadochi Y, Takahashi K, Fukushima K, Yamasaki E, Uemoto T, et al. Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells. Exp Cell Res. 2016;342:193-9 pubmed publisher
    ..G-protein-coupled receptor 120 (GPR120) and GPR40 are identified as FFARs for long- and medium-chain fatty acids...
  57. Castilla Madrigal R, Barrenetxe J, Moreno Aliaga M, Lostao M. EPA blocks TNF-?-induced inhibition of sugar uptake in Caco-2 cells via GPR120 and AMPK. J Cell Physiol. 2017;: pubmed publisher
    ..The GPR120 antagonist, AH7614, also blocked the preventive effect of EPA on TNF-?-induced decrease of ?MG uptake and AMPK ..
  58. Tran D, Ramos E, Belsham D. Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP. Mol Cell Endocrinol. 2016;426:125-35 pubmed publisher
    ..AH7614, K252c, U0126, wortmannin, and LY294002, we demonstrate that the effect of DHA is mediated through GPR120 to downstream PKC/MAPK and PI3K signaling...
  59. Serna Marquez N, Díaz Aragon R, Reyes Uribe E, Cortes Reynosa P, Salazar E. Linoleic acid induces migration and invasion through FFAR4- and PI3K-/Akt-dependent pathway in MDA-MB-231 breast cancer cells. Med Oncol. 2017;34:111 pubmed publisher
    ..Moreover, Akt2 activation requires EGFR and PI3K activity, whereas migration and invasion are dependent on FFAR4, EGFR and PI3K/Akt activity...
  60. Sparks S, Aquino C, Banker P, Collins J, Cowan D, Diaz C, et al. Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist. Bioorg Med Chem Lett. 2017;27:1278-1283 pubmed publisher
    The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient sensing and inflammation and thus holds potential as a therapeutic target for type 2 diabetes and ..
  61. Quesada López T, Cereijo R, Turatsinze J, Planavila A, Cairó M, Gavaldà Navarro A, et al. The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes. Nat Commun. 2016;7:13479 pubmed publisher
    ..Here we show that GPR120, a receptor for polyunsaturated fatty acids, promotes brown fat activation...
  62. Gao B, Han Y, Wang L, Lin Y, Sun Z, Lu W, et al. Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells. Cell Death Dis. 2016;7:e2235 pubmed publisher
    ..We also observed that EPA-induced autophagy was modulated by GPR120, but not GPR40...
  63. Sankoda A, Harada N, Iwasaki K, Yamane S, Murata Y, Shibue K, et al. Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice. Endocrinology. 2017;158:1172-1180 pubmed publisher
    Free fatty acid receptors GPR120 and GPR40 are involved in the secretion of gut hormones...
  64. Im D. FFA4 (GPR120) as a fatty acid sensor involved in appetite control, insulin sensitivity and inflammation regulation. Mol Aspects Med. 2018;64:92-108 pubmed publisher
    ..The recent discovery that free fatty acid receptor 4 (FFA4, also known as GPR120) acts as a sensor for unsaturated long-chain fatty acids started to unveil ..
  65. Shewale S, Brown A, Bi X, Boudyguina E, Sawyer J, Alexander Miller M, et al. In vivo activation of leukocyte GPR120/FFAR4 by PUFAs has minimal impact on atherosclerosis in LDL receptor knockout mice. J Lipid Res. 2017;58:236-246 pubmed publisher
    G protein-coupled receptor (GPR)120/FFA receptor (FFAR)4 (GPR120/FFAR4) activation by n-3 PUFAs attenuates inflammation, but its impact on atherosclerosis is unknown...
  66. Gozal D, Kheirandish Gozal L, Carreras A, Khalyfa A, Peris E. Obstructive sleep apnea and obesity are associated with reduced GPR 120 plasma levels in children. Sleep. 2014;37:935-41 pubmed publisher
    ..The short- and long-term significance of reduced GPR 120 relative to food intake and glycemic deregulation remains undefined. ..
  67. Gao B, Huang Q, Jie Q, Lu W, Wang L, Li X, et al. GPR120: A bi-potential mediator to modulate the osteogenic and adipogenic differentiation of BMMSCs. Sci Rep. 2015;5:14080 pubmed publisher
    ..b>GPR120, a G protein-coupled receptor for long-chain unsaturated fatty acids, has been reported to mediate adipogenesis in ..
  68. Vallée Marcotte B, Cormier H, Rudkowska I, Lemieux S, Couture P, Vohl M. Polymorphisms in FFAR4 (GPR120) Gene Modulate Insulin Levels and Sensitivity after Fish Oil Supplementation. J Pers Med. 2017;7: pubmed publisher
    The objective was to test whether FFAR4 single nucleotide polymorphisms (SNPs) are associated with glycemic control-related traits in humans following fish oil supplementation...