Gene Symbol: FEZ2
Description: fasciculation and elongation protein zeta 2
Alias: HUM3CL, fasciculation and elongation protein zeta-2, pre-T/NK cell associated protein (3Cl), zygin 2, zygin II
Species: human
Products:     FEZ2

Top Publications

  1. Fujita T, Ikuta J, Hamada J, Okajima T, Tatematsu K, Tanizawa K, et al. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Biochem Biophys Res Commun. 2004;313:738-44 pubmed
    ..The gene coding for FEZ2, a homologue of FEZ1, has also been reported in rat and human...
  2. Bloom L, Horvitz H. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc Natl Acad Sci U S A. 1997;94:3414-9 pubmed
  3. Assmann E, Alborghetti M, Camargo M, Kobarg J. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J Biol Chem. 2006;281:9869-81 pubmed
    ..We reported previously that FEZ1 and its paralogue FEZ2 are proteins that interact with NEK1, a protein kinase involved in polycystic kidney disease and DNA repair ..
  4. Yu H, You X, Li J, Liu H, Meng Z, Xiao L, et al. Genome-Wide Mapping of Growth-Related Quantitative Trait Loci in Orange-Spotted Grouper (Epinephelus coioides) Using Double Digest Restriction-Site Associated DNA Sequencing (ddRADseq). Int J Mol Sci. 2016;17:501 pubmed publisher
    ..98 cM. Twenty-seven significant growth-related QTLs were identified. Furthermore, we identified 17 genes (fez2, alg3, ece2, arvcf, sla27a4, sgk223, camk2, prrc2b, mchr1, sardh, pappa, syk, tert, wdrcp91, ftz-f1, mate1 and ..
  5. Ranes Goldberg M, Hori T, Mohan Peterson S, Spits H. Identification of human pre-T/NK cell-associated genes. J Immunol. 1993;151:5810-21 pubmed
    ..Genes identified in this study may be useful not only as markers for early stages of T/NK cell ontogeny, but also as tools for understanding novel developmental events. ..
  6. Kolle G, Georgas K, Holmes G, Little M, Yamada T. CRIM1, a novel gene encoding a cysteine-rich repeat protein, is developmentally regulated and implicated in vertebrate CNS development and organogenesis. Mech Dev. 2000;90:181-93 pubmed
    ..Our results suggest a role for CRIM1/Crim1 in CNS development possibly via growth factor binding. ..
  7. Surpili M, Delben T, Kobarg J. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Biochemistry. 2003;42:15369-76 pubmed
    ..Our results give further support to the previous observation that NEK1 is of functional importance for the etiology of PKD. ..
  8. Alborghetti M, Furlan A, Kobarg J. FEZ2 has acquired additional protein interaction partners relative to FEZ1: functional and evolutionary implications. PLoS ONE. 2011;6:e17426 pubmed publisher
    ..elegans unc-76. Similar human sequences were identified in the expressed sequence tag database as FEZ1 and FEZ2. The unc-76 function is necessary for normal axon fasciculation and is required for axon-axon interactions...
  9. Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, et al. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy. 2014;10:2297-309 pubmed publisher
    ..Moreover, we analyzed RAB3GAP1/2 in relation to the previously reported suppressive autophagy modulators FEZ1 and FEZ2 and demonstrate that both reciprocally regulate autophagy...

More Information


  1. Hapairai L, Mysore K, Chen Y, Harper E, Scheel M, Lesnik A, et al. Lure-and-Kill Yeast Interfering RNA Larvicides Targeting Neural Genes in the Human Disease Vector Mosquito Aedes aegypti. Sci Rep. 2017;7:13223 pubmed publisher
    ..to produce short hairpin RNAs (shRNAs) corresponding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and leukocyte receptor cluster (lrc) member, two genes identified in a recent screen for ..