FEZ1

Summary

Gene Symbol: FEZ1
Description: fasciculation and elongation protein zeta 1
Alias: UNC-76, fasciculation and elongation protein zeta-1, zygin I, zygin-1
Species: human
Products:     FEZ1

Top Publications

  1. Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, et al. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry. 2003;8:685-94 pubmed
    ..Here, we demonstrated the existence of DISC1 protein and identified fasciculation and elongation protein zeta-1 (FEZ1) as an interacting partner of DISC1 by a yeast two-hybrid study...
  2. Blasius T, Cai D, Jih G, Toret C, Verhey K. Two binding partners cooperate to activate the molecular motor Kinesin-1. J Cell Biol. 2007;176:11-7 pubmed
    ..We identified fasciculation and elongation protein zeta1 (FEZ1) as a binding partner of kinesin heavy chain...
  3. Lanza D, Trindade D, Assmann E, Kobarg J. Over-expression of GFP-FEZ1 causes generation of multi-lobulated nuclei mediated by microtubules in HEK293 cells. Exp Cell Res. 2008;314:2028-39 pubmed publisher
    FEZ1 (Fasciculation and elongation protein zeta 1) is an ortholog of the Caenorhabditis elegans protein UNC-76, involved in neuronal development and axon outgrowth, in that worm...
  4. Suzuki T, Okada Y, Semba S, Orba Y, Yamanouchi S, Endo S, et al. Identification of FEZ1 as a protein that interacts with JC virus agnoprotein and microtubules: role of agnoprotein-induced dissociation of FEZ1 from microtubules in viral propagation. J Biol Chem. 2005;280:24948-56 pubmed
    ..We have now identified fasciculation and elongation protein zeta 1 (FEZ1) as a protein that interacted with JCV agnoprotein in a yeast two-hybrid screen of a ..
  5. Yu Z, Ono C, Kim H, Komatsu H, Tanabe Y, Sakae N, et al. Four mood stabilizers commonly induce FEZ1 expression in human astrocytes. Bipolar Disord. 2011;13:486-99 pubmed publisher
    ..The intercellular localization of one of these regulated genes, fasciculation and elongation protein zeta 1 (FEZ1), was evaluated by immunofluorescence staining...
  6. Whitehouse C, Chambers J, Howe K, Cobourne M, Sharpe P, Solomon E. NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube. Eur J Biochem. 2002;269:538-45 pubmed
    ..Here, we show that NBR1 interacts with two proteins; fasciculation and elongation protein zeta-1 (FEZ1), a PKCzeta interacting protein, and calcium and integrin binding protein (CIB), which is associated with polo-like ..
  7. Bloom L, Horvitz H. The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation. Proc Natl Acad Sci U S A. 1997;94:3414-9 pubmed
  8. Okumura F, Hatakeyama S, Matsumoto M, Kamura T, Nakayama K. Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. J Biol Chem. 2004;279:53533-43 pubmed
    ..With a yeast two-hybrid screen, we have now identified FEZ1 (fasciculation and elongation protein zeta 1) as a protein that interacts with E4B...
  9. Alborghetti M, Furlan A, Kobarg J. FEZ2 has acquired additional protein interaction partners relative to FEZ1: functional and evolutionary implications. PLoS ONE. 2011;6:e17426 pubmed publisher
    ..elegans unc-76. Similar human sequences were identified in the expressed sequence tag database as FEZ1 and FEZ2. The unc-76 function is necessary for normal axon fasciculation and is required for axon-axon interactions...

More Information

Publications49

  1. Lanza D, Meirelles G, Alborghetti M, Abrile C, Lenz G, Kobarg J. FEZ1 interacts with CLASP2 and NEK1 through coiled-coil regions and their cellular colocalization suggests centrosomal functions and regulation by PKC. Mol Cell Biochem. 2010;338:35-45 pubmed publisher
    b>FEZ1 was initially described as a neuronal protein that influences axonal development and cell polarization...
  2. Alborghetti M, Furlan A, Silva J, Paes Leme A, Torriani I, Kobarg J. Human FEZ1 protein forms a disulfide bond mediated dimer: implications for cargo transport. J Proteome Res. 2010;9:4595-603 pubmed publisher
    The human proteins FEZ1 (fasciculation and elongation protein zeta 1) and FEZ2 are orthologs of the protein UNC-76 from C. elegans, involved in the growth and fasciculation of the worms axon...
  3. Lanza D, Silva J, Assmann E, Quaresma A, Bressan G, Torriani I, et al. Human FEZ1 has characteristics of a natively unfolded protein and dimerizes in solution. Proteins. 2009;74:104-21 pubmed publisher
    The fasciculation and elongation protein Zeta 1 (FEZ1) is the mammalian orthologue of the Caenorhabditis elegans protein UNC-76, which is necessary for axon growth...
  4. Chua J, Butkevich E, Worseck J, Kittelmann M, Gr Nborg M, Behrmann E, et al. Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter. Proc Natl Acad Sci U S A. 2012;109:5862-7 pubmed publisher
    ..vesicle exocytosis at the presynaptic plasma membrane, to the motor protein Kinesin-1 via the kinesin adaptor FEZ1. Mutation of the FEZ1 ortholog UNC-76 in Caenorhabditis elegans causes defects in the axonal transport of Stx...
  5. Assmann E, Alborghetti M, Camargo M, Kobarg J. FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region. J Biol Chem. 2006;281:9869-81 pubmed
    The fasciculation and elongation protein zeta1 (FEZ1) is a mammalian orthologue of the Caenorhabditis elegans protein UNC-76, which is necessary for axon growth in that nematode...
  6. Kuroda S, Nakagawa N, Tokunaga C, Tatematsu K, Tanizawa K. Mammalian homologue of the Caenorhabditis elegans UNC-76 protein involved in axonal outgrowth is a protein kinase C zeta-interacting protein. J Cell Biol. 1999;144:403-11 pubmed
    ..The protein designated FEZ1 (fasciculation and elongation protein zeta-1) consisting of 393 amino acid residues shows a high Asp/Glu content ..
  7. Watanabe Y, Khodosevich K, Monyer H. Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system. Cell Rep. 2014;7:552-564 pubmed publisher
    Downregulation of the schizophrenia-associated gene DISC1 and its interacting protein FEZ1 positively regulates dendrite growth in young neurons...
  8. Tohyama M, Miyata S, Hattori T, Shimizu S, Matsuzaki S. Molecular basis of major psychiatric diseases such as schizophrenia and depression. Anat Sci Int. 2015;90:137-43 pubmed publisher
    ..development directly via adhesion molecules or via its binding partners of DISC1 such as elongation protein ζ-1 (FEZ1), DISC1-binding zinc-finger protein (DBZ) and kendrin...
  9. Qadir F, Aziz M, Sari C, Ma H, Dai H, Wang X, et al. Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Mol Cancer. 2018;17:97 pubmed publisher
    ..exosomes altered molecular programmes involved in matrix modulation (MMP9), cytoskeletal remodelling (TUBB6, FEZ1, CCT6A), viral/dsRNA-induced interferon (OAS1, IFI6), anti-inflammatory (TSC22D3), deubiquitin (OTUD1), lipid ..
  10. Zhou W, He M, Jiao H, He L, Deng D, Cai J, et al. The tumor-suppressor gene LZTS1 suppresses colorectal cancer proliferation through inhibition of the AKT-mTOR signaling pathway. Cancer Lett. 2015;360:68-75 pubmed publisher
    The Leucine zipper tumor suppressor gene 1 (LZTS1/FEZ1) gene was originally identified as a potential tumor suppressor...
  11. Rampino A, Walker R, Torrance H, Anderson S, Fazio L, Di Giorgio A, et al. Expression of DISC1-interactome members correlates with cognitive phenotypes related to schizophrenia. PLoS ONE. 2014;9:e99892 pubmed publisher
    ..Finally, the expression levels of DISC1, AKAP9, FEZ1, NDEL1 and PCM1 were compared between 63 controls and 69 schizophrenic subjects...
  12. Sure G, Chatterjee A, Mishra N, Sabharwal V, Devireddy S, Awasthi A, et al. UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport. Sci Rep. 2018;8:8938 pubmed publisher
    ..Mutants in the Kinesin-1 associated proteins, UNC-16/JIP3 and UNC-76/FEZ1, show increased mitochondrial density and also have elevated levels of both the Kinesin Heavy and Light Chains in ..
  13. Mayanagi T, Yasuda H, Sobue K. PSD-Zip70 Deficiency Causes Prefrontal Hypofunction Associated with Glutamatergic Synapse Maturation Defects by Dysregulation of Rap2 Activity. J Neurosci. 2015;35:14327-40 pubmed publisher
    ..PSD-Zip70 (Lzts1/FEZ1) is a postsynaptic density (PSD) protein predominantly expressed in the frontal cortex, olfactory bulb, striatum, ..
  14. Kumarasinghe I, Woster P. Cyclic peptide inhibitors of lysine-specific demethylase 1 with improved potency identified by alanine scanning mutagenesis. Eur J Med Chem. 2018;148:210-220 pubmed publisher
    ..16, 27 and 28 promoted significant increases in H3K4me2 levels at the promoter sites of the genes IGFBP2 and FEZ1. Data from these LSD1 inhibitors will aid in the design of peptidomimetics with improved stability and ..
  15. Butkevich E, Härtig W, Nikolov M, Erck C, Grosche J, Urlaub H, et al. Phosphorylation of FEZ1 by Microtubule Affinity Regulating Kinases regulates its function in presynaptic protein trafficking. Sci Rep. 2016;6:26965 pubmed publisher
    ..Here, we show that cargoes transported by the Kinesin-1 adapter FEZ1 are enriched for presynaptic components and identify that specific phosphorylation of FEZ1 at its serine 58 ..
  16. Saribas A, Coric P, Hamazaspyan A, Davis W, Axman R, White M, et al. Emerging From the Unknown: Structural and Functional Features of Agnoprotein of Polyomaviruses. J Cell Physiol. 2016;231:2115-27 pubmed publisher
    ..It associates with cellular proteins, including YB-1, p53, Ku70, FEZ1, HP1?, PP2A, AP-3, PCNA, and ?-SNAP; and viral proteins, including small t antigen, large T antigen, HIV-1 Tat, and ..
  17. Tang J, Fan Y, Li H, Xiang Q, Zhang D, Li Z, et al. Whole-genome sequencing of monozygotic twins discordant for schizophrenia indicates multiple genetic risk factors for schizophrenia. J Genet Genomics. 2017;44:295-306 pubmed publisher
    ..we were able to distill genetic alterations in several schizophrenia risk genes, including GAD1, PLXNA2, RELN and FEZ1. Four inherited copy number variations (CNVs; including a large deletion at 16p13...
  18. Malikov V, da Silva E, Jovasevic V, Bennett G, de Souza Aranha Vieira D, Schulte B, et al. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun. 2015;6:6660 pubmed publisher
    ..virus type 1 (HIV-1) associates with the kinesin-1 adaptor protein, Fasiculation and Elongation Factor zeta 1 (FEZ1)...
  19. Haedicke J, Brown C, Naghavi M. The brain-specific factor FEZ1 is a determinant of neuronal susceptibility to HIV-1 infection. Proc Natl Acad Sci U S A. 2009;106:14040-5 pubmed publisher
    ..chemically mutagenized and selected for resistance to retroviral infection, we recently identified induction of rat FEZ1 (fasciculation and elongation protein zeta-1), a brain-specific protein, as the cause of this resistance...
  20. Ren J, Zhao T, Xu Y, Ye H. Interaction between DISC1 and CHL1 in regulation of neurite outgrowth. Brain Res. 2016;1648:290-297 pubmed publisher
    ..DISC1 regulates neurite length via interaction with several intracellular proteins, such as NDEL1, FEZ1 and dysbindin...
  21. Koga M, Ishiguro H, Horiuchi Y, Albalushi T, Inada T, Iwata N, et al. Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population. Neurosci Lett. 2007;417:326-9 pubmed
    Fasciculation and elongation of protein zeta-1 (FEZ1) is a binding partner of Disrupted-In-Schizophrenia 1 (DISC1)...
  22. Aberg K, Liu Y, Bukszar J, McClay J, Khachane A, Andreassen O, et al. A comprehensive family-based replication study of schizophrenia genes. JAMA Psychiatry. 2013;70:573-81 pubmed
    ..We replicated novel SCZ disease genes and pathogenic pathways. Better understanding the molecular and biological mechanisms involved with schizophrenia may improve disease management and may identify new drug targets. ..
  23. A P S, Laishram R. Nuclear Phosphatidylinositol-Phosphate Type I Kinase α-Coupled Star-PAP Polyadenylation Regulates Cell Invasion. Mol Cell Biol. 2018;38: pubmed publisher
    ..of pre-mRNAs encoding key anti-invasive factors (KISS1R, CDH1, NME1, CDH13, FEZ1, and WIF1) in breast cancer...
  24. Maturana A, Fujita T, Kuroda S. Functions of fasciculation and elongation protein zeta-1 (FEZ1) in the brain. ScientificWorldJournal. 2010;10:1646-54 pubmed publisher
    Fasciculation and elongation protein zeta-1 (FEZ1) is a mammalian ortholog of the Caenorhabditis elegans UNC-76 protein that possesses four coiled-coil domains and a nuclear localization signal. It is mainly expressed in the brain...
  25. Nicodemus K, Callicott J, Higier R, Luna A, Nixon D, Lipska B, et al. Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging. Hum Genet. 2010;127:441-52 pubmed publisher
    ..susceptibility gene, encodes a protein which interacts with many other proteins, including CIT, NDEL1, NDE1, FEZ1 and PAFAH1B1, some of which also have been associated with psychosis...
  26. Wong Y, Rice S. Kinesin's light chains inhibit the head- and microtubule-binding activity of its tail. Proc Natl Acad Sci U S A. 2010;107:11781-6 pubmed publisher
    ..KLC-mediated inhibition of tail-microtubule binding may also influence diffusional movement of kinesin-1 on microtubules, and kinesin-1's role in microtubule transport/sliding. ..
  27. Surpili M, Delben T, Kobarg J. Identification of proteins that interact with the central coiled-coil region of the human protein kinase NEK1. Biochemistry. 2003;42:15369-76 pubmed
    ..Our results give further support to the previous observation that NEK1 is of functional importance for the etiology of PKD. ..
  28. Yamada K, Nakamura K, Minabe Y, Iwayama Shigeno Y, Takao H, Toyota T, et al. Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. Biol Psychiatry. 2004;56:683-90 pubmed
    DISC1 has been suggested as a causative gene for psychoses in a large Scottish family. We recently identified FEZ1 as an interacting partner for DISC1...
  29. Newburn E, Hyde T, Ye T, Morita Y, Weinberger D, Kleinman J, et al. Interactions of human truncated DISC1 proteins: implications for schizophrenia. Transl Psychiatry. 2011;1:e30 pubmed publisher
    ..HEK293) cells were transiently co-transfected with human epitope-tagged DISC1 variants and epitope-tagged NDEL1, FEZ1, GSK3? and PDE4B constructs...
  30. Tomppo L, Hennah W, Lahermo P, Loukola A, Tuulio Henriksson A, Suvisaari J, et al. Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses. Biol Psychiatry. 2009;65:1055-62 pubmed publisher
    ..Our findings with other converging lines of evidence support the underlying importance of DISC1-related molecular pathways in the etiology of schizophrenia and other major mental illnesses. ..
  31. Rastogi A, Zai C, Likhodi O, Kennedy J, Wong A. Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia. Schizophr Res. 2009;114:39-49 pubmed publisher
    ..families; N=210 case-control pairs), testing polymorphisms across DISC1 and DISC1 interacting genes: LIS1, NUDEL, FEZ1 and PDE4B...
  32. Spang N, Feldmann A, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, et al. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Autophagy. 2014;10:2297-309 pubmed publisher
    ..Moreover, we analyzed RAB3GAP1/2 in relation to the previously reported suppressive autophagy modulators FEZ1 and FEZ2 and demonstrate that both reciprocally regulate autophagy...
  33. Alborghetti M, Furlan A, da Silva J, Sforça M, Honorato R, Granato D, et al. Structural analysis of intermolecular interactions in the kinesin adaptor complex fasciculation and elongation protein zeta 1/ short coiled-coil protein (FEZ1/SCOCO). PLoS ONE. 2013;8:e76602 pubmed publisher
    ..The human protein FEZ1 (fasciculation and elongation protein zeta 1 / UNC-76, in C. elegans), SCOCO (short coiled-coil protein / UNC-69) and kinesins (e.g...
  34. Bryant D, Landles C, Papadopoulou A, Benjamin A, Duckworth J, Rosahl T, et al. Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice. Sci Rep. 2017;7:11900 pubmed publisher
    ..neural cells we observed decreased expression of schizophrenia-associated gene Fez1 (fasciculation and elongation protein zeta 1), a gene previously reported to be regulated by HDAC11 activity...
  35. Malikov V, Naghavi M. Localized Phosphorylation of a Kinesin-1 Adaptor by a Capsid-Associated Kinase Regulates HIV-1 Motility and Uncoating. Cell Rep. 2017;20:2792-2799 pubmed publisher
    ..recently showed that the capsid-associated kinesin-1 adaptor protein, fasciculation and elongation protein zeta-1 (FEZ1), regulates HIV-1 trafficking...
  36. Colantuoni C, Hyde T, Mitkus S, Joseph A, Sartorius L, Aguirre C, et al. Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex. Brain Struct Funct. 2008;213:255-71 pubmed publisher
    ..Expression of FEZ1, GAD1, and RGS4 showed especially high correlation with one another, in addition to the strongest mean levels of ..
  37. Chen X, Ku L, Mei R, Liu G, Xu C, Wen Z, et al. Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development. Transl Psychiatry. 2017;7:1293 pubmed publisher
    ..and regulation of the well-recognized schizophrenia risk factor, Fasciculation and Elongation Protein Zeta-1 (FEZ1), in OL...
  38. Behrens C, Binotti B, Schmidt C, Robinson C, Chua J, Kühnel K. Crystal structure of the human short coiled coil protein and insights into SCOC-FEZ1 complex formation. PLoS ONE. 2013;8:e76355 pubmed publisher
    The short coiled coil protein (SCOC) forms a complex with fasciculation and elongation protein zeta 1 (FEZ1). This complex is involved in autophagy regulation...
  39. Kang E, Burdick K, Kim J, Duan X, Guo J, Sailor K, et al. Interaction between FEZ1 and DISC1 in regulation of neuronal development and risk for schizophrenia. Neuron. 2011;72:559-71 pubmed publisher
    ..Here, we show that Fasciculation and Elongation Protein Zeta-1 (FEZ1) interacts with DISC1 to synergistically regulate dendritic growth of newborn neurons in the adult mouse ..