Gene Symbol: FDX1
Description: ferredoxin 1
Alias: ADX, FDX, LOH11CR1D, adrenodoxin, mitochondrial, adrenal ferredoxin, hepatoredoxin, mitochondrial adrenodoxin
Species: human
Products:     FDX1

Top Publications

  1. Yang J, Xie X, Yang M, Dixon R, Wang Y. Modular electron-transport chains from eukaryotic organelles function to support nitrogenase activity. Proc Natl Acad Sci U S A. 2017;114:E2460-E2465 pubmed publisher
    ..We pinpoint endogenous ETCs from plant organelles as power supplies to support nitrogenase for future engineering of diazotrophy in cereal crops. ..
  2. Bajpai P, Srinivasan S, Ghosh J, Nagy L, Wei S, Guengerich F, et al. Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction. J Biol Chem. 2014;289:29614-30 pubmed publisher
    ..This study suggests that mitochondrially targeted variant 3 CYP2C8 may contribute to oxidative stress in various tissues. ..
  3. Kharechkina E, Nikiforova A, Kruglov A. Pyridine nucleotides regulate the superoxide anion flash upon permeabilization of mitochondrial membranes: An MCLA-based study. Free Radic Biol Med. 2018;124:473-483 pubmed publisher
  4. Zhang A, Zhang T, Hall E, Hutchinson S, Cryle M, Wong L, et al. The crystal structure of the versatile cytochrome P450 enzyme CYP109B1 from Bacillus subtilis. Mol Biosyst. 2015;11:869-81 pubmed publisher
    ..The crystal structure of CYP109B1 has a positively charged proximal face and this explains why it can interact with PFOR and adrenodoxin which are predominantly negatively charged around their [2Fe-2S] clusters. ..
  5. Long Y, Han S, Zhang X, Zhang X, Chen T, Gao Y, et al. The combination of a novel 2 bp deletion mutation and p.D63H in CYP11B1 cause congenital adrenal hyperplasia due to steroid 11β-hydroxylase deficiency. Endocr J. 2016;63:301-10 pubmed publisher
    ..9525_9526delCT, corresponding to p.L380V…R420X) and known missense mutation (g.5194G>C corresponding to p.D63H) in CYP11B1. ..
  6. Cormier M, Ghouili F, Roumaud P, Bauer W, Touaibia M, Martin L. Influences of flavones on cell viability and cAMP-dependent steroidogenic gene regulation in MA-10 Leydig cells. Cell Biol Toxicol. 2018;34:23-38 pubmed publisher
    ..Low levels of apigenin, luteolin, chrysin, and baicalein (10 μM) stimulated cAMP-dependent Star, Cyp11a1, and Fdx1 promoters' activation and may increase steroidogenesis within Leydig cells...
  7. Pan Z, Fang Z, Lu W, Liu X, Zhang Y. Osthole, a coumadin analog from Cnidium monnieri (L.) Cusson, stimulates corticosterone secretion by increasing steroidogenic enzyme expression in mouse Y1 adrenocortical tumor cells. J Ethnopharmacol. 2015;175:456-62 pubmed publisher
    ..mRNA expression in a dose-dependent manner and enhanced the expression of transcription factors such as HSD3B1, FDX1, POR and RXRα as well as immediate early genes such as NR4A1...
  8. Sim Y, Park S, Kim S, Lim S, Jung J, Suh H. Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow. Eur J Pharmacol. 2014;741:316-22 pubmed publisher
    ..The elevated blood glucose level induced by clonidine was significantly decreased in adrenalectomized (ADX) mice...
  9. Yan R, Adinolfi S, Pastore A. Ferredoxin, in conjunction with NADPH and ferredoxin-NADP reductase, transfers electrons to the IscS/IscU complex to promote iron-sulfur cluster assembly. Biochim Biophys Acta. 2015;1854:1113-7 pubmed publisher
    ..We also show that, despite overlapping with the CyaY protein in binding to IscS, Fdx does not interfere with the inhibitory activity of this protein...

More Information

Publications134 found, 100 shown here

  1. Cormier M, Ghouili F, Roumaud P, Martin L, Touaibia M. Influence of flavonols and quercetin derivative compounds on MA-10 Leydig cells steroidogenic genes expressions. Toxicol In Vitro. 2017;44:111-121 pubmed publisher
    ..Low levels of quercetin, myricetin and pentaacetylquercetin (10μM) stimulated cAMP-dependent Star, Cyp11a1 and Fdx1 promoters' activations and may increase steroidogenesis within Leydig cells...
  2. Nikolova D, Heilmann C, Hawat S, Gäbelein P, Hippler M. Absolute quantification of selected photosynthetic electron transfer proteins in Chlamydomonas reinhardtii in the presence and absence of oxygen. Photosynth Res. 2018;137:281-293 pubmed publisher
    ..both proteins, which might further enhance the competition for electrons, the alga is capable of hydrogen production under anaerobic conditions, thus pointing to an efficient channeling mechanism of electrons from FDX1 to the HYDA1.
  3. Buey R, Fernández Justel D, de Pereda J, Revuelta J, Schürmann P, Buchanan B, et al. Ferredoxin-linked flavoenzyme defines a family of pyridine nucleotide-independent thioredoxin reductases. Proc Natl Acad Sci U S A. 2018;115:12967-12972 pubmed publisher
    ..structures revealed an alternative domain organization compared with NTR that enables the enzyme to accommodate Fdx rather than NADPH...
  4. Olive J, Cowan J. Role of the HSPA9/HSC20 chaperone pair in promoting directional human iron-sulfur cluster exchange involving monothiol glutaredoxin 5. J Inorg Biochem. 2018;184:100-107 pubmed publisher
    ..Cluster exchange with the human iron‑sulfur cluster carrier protein NFU1 and ferredoxins (FDX's), and the role of chaperones, has also been evaluated, demonstrating in certain cases control over the ..
  5. Sun Y, Ma L, Han D, Du L, Qi F, Zhang W, et al. In vitro reconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins. J Ind Microbiol Biotechnol. 2017;44:161-166 pubmed publisher
    ..Moreover, the supporting activities of a set of ferredoxin (Fdx)/ferredoxin reductase (FdR) pairs from the cyanobacterium Synechococcus elongatus PCC 7942 were comparatively ..
  6. Weigel M, Riester A, Hanslik G, Lang K, Willenberg H, Endres S, et al. Post-saline infusion test aldosterone levels indicate severity and outcome in primary aldosteronism. Eur J Endocrinol. 2015;172:443-50 pubmed publisher
    ..5±1.4, P=0.001), had a faster normalization of urinary protein excretion (with medical treatment P=0.049; with Adx P<0.005) at follow-up, and more frequently underlying well-characterized mutation (P=0.047)...
  7. Chotiwat C, Kelso E, Harris R. The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors. Stress. 2010;13:203-13 pubmed publisher
    ..By contrast, exploration increased in RRS ADX mice. Testing in the EPM increased serum corticosterone level in all WT and CRFR2-KO mice...
  8. Feofanova E, Yu B, Metcalf G, Liu X, Muzny D, Below J, et al. Sequence-Based Analysis of Lipid-Related Metabolites in a Multiethnic Study. Genetics. 2018;209:607-616 pubmed publisher
    ..The regions contain genes that are related to metabolite transport (SLC10A1) and metabolism (SCD, FDX1, UGT2B15, and FADS2)...
  9. Martinez P, Baldan Martin M, Lopez J, Martin Lorenzo M, Santiago Hernández A, Agudiez M, et al. Identification of six cardiovascular risk biomarkers in the young population: A promising tool for early prevention. Atherosclerosis. 2019;282:67-74 pubmed publisher
    ..4309 proteins were identified, 75 of them differentially expressed. ADX, ECP, FETUB, GDF15, GUAD and NOTCH1 compose a fingerprint positively correlating with lifetime risk estimate (LTR ..
  10. Gotlieb N, Albaz E, Shaashua L, Sorski L, Matzner P, Rosenne E, et al. Regeneration of functional adrenal tissue following bilateral adrenalectomy. Endocrinology. 2017;: pubmed publisher
    ..We conclude that ADX animals may develop compensatory mechanisms, and suggest that studies employing ADX consider additional ..
  11. Cao X, Durairaj P, Yang F, Bureik M. A comprehensive overview of common polymorphic variants that cause missense mutations in human CYPs and UGTs. Biomed Pharmacother. 2019;111:983-992 pubmed publisher
    ..all common SNP variants that lead to missense mutations in CYPs and UGTs or in their helping proteins CPR, AdR, Adx, and UGDH...
  12. Shao L, Chian R, Xu Y, Yan Z, Zhang Y, Gao C, et al. Genomic expression profiles in cumulus cells derived from germinal vesicle and MII mouse oocytes. Reprod Fertil Dev. 2015;: pubmed publisher
    ..to epidermal growth factor, extracellular matrix (Ptgs2, Ereg, Tnfaip6 and Efemp1), mitochondrial metabolism (Fdx1 and Aifm2), gap junctions and the cell cycle (Gja1, Gja4, Ccnd2, Ccna2 and Ccnb2) were highlighted as being ..
  13. Chen J, Wang Z, Zhang S, Chu S, Mou Z, Chen N. The effects of glucocorticoids on depressive and anxiety-like behaviors, mineralocorticoid receptor-dependent cell proliferation regulates anxiety-like behaviors. Behav Brain Res. 2019;362:288-298 pubmed publisher
    ..of tryptophan hydroxylase-2 (TPH2) were decreased after CUS in the hippocampus in sham rats, while adrenalectomy (ADX) prevented such decreases...
  14. Sun Q, Li M, Rui H, Chen Y. Inhibition of local aldosterone by eplerenone reduces renal structural damage in a novel model of chronic cyclosporine A nephrotoxicity. J Renin Angiotensin Aldosterone Syst. 2015;16:301-10 pubmed publisher
    ..we evaluated the effect of eplerenone (Epl) on renal structural damage and renal dysfunction in adrenalectomized (ADX) rats, and assessed whether the therapeutic benefit was associated with reduction of transforming growth factor-β..
  15. Mostaghel E, Zhang A, Hernandez S, Marck B, Zhang X, Tamae D, et al. Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer. Clin Cancer Res. 2019;25:426-439 pubmed publisher
    ..We evaluated tumor growth and androgens in LuCaP35CR and LuCaP96CR xenografts in response to adrenalectomy (ADX). We assessed protein expression of key steroidogenic enzymes in 185 CRPC metastases from 42 patients...
  16. Ershov P, Yablokov Е, Florinskaya A, Mezentsev Y, Kaluzhskiy L, Tumilovich A, et al. SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates. J Steroid Biochem Mol Biol. 2019;187:124-129 pubmed publisher
    ..partners: cytochrome b5 (CYB5A), NADPH - cytochrome P450 reductase (CPR), and also iron-sulfur protein adrenodoxin (Adx)...
  17. García Pérez D, Ferenczi S, Kovacs K, Milanes M. Distinct regulation pattern of Egr-1, BDNF and Arc during morphine-withdrawal conditioned place aversion paradigm: Role of glucocorticoids. Behav Brain Res. 2019;360:244-254 pubmed publisher
    ..In the present study, place aversion was elicited in sham and adrenalectomized (ADX) animals by conditioned naloxone-precipitated drug withdrawal following exposure to chronic morphine...
  18. Palandri A, L Hôte D, Cohen Tannoudji J, Tricoire H, Monnier V. Frataxin inactivation leads to steroid deficiency in flies and human ovarian cells. Hum Mol Genet. 2015;24:2615-26 pubmed publisher
    ..In mammals, adrenodoxin, the ferredoxin FDX1, is an Fe-S-containing protein essential for the synthesis of various steroid hormones...
  19. Mosebach L, Heilmann C, Mutoh R, Gäbelein P, Steinbeck J, Happe T, et al. Association of Ferredoxin:NADP+ oxidoreductase with the photosynthetic apparatus modulates electron transfer in Chlamydomonas reinhardtii. Photosynth Res. 2017;134:291-306 pubmed publisher
    ..measurements as well as NMR chemical shift perturbation analyses showed that FNR preferentially interacts with FDX1 compared to FDX2...
  20. Shivers K, Amador N, Abrams L, Hunter D, Jenab S, Quiñones Jenab V. Estrogen alters baseline and inflammatory-induced cytokine levels independent from hypothalamic-pituitary-adrenal axis activity. Cytokine. 2015;72:121-9 pubmed publisher
    ..cholesterol) treated female rats following ovariectomy/sham adrenalectomy (OVX), adrenalectomy/sham ovariectomy (ADX) or ADX+OVX operation at baseline and post formalin injection...
  21. Zalewski A, Ma N, Legeza B, Renthal N, Flück C, Pandey A. Vitamin D-Dependent Rickets Type 1 Caused by Mutations in CYP27B1 Affecting Protein Interactions With Adrenodoxin. J Clin Endocrinol Metab. 2016;101:3409-18 pubmed publisher
    ..Mitochondrial cytochrome P450s require adrenodoxin (FDX1) and adrenodoxin reductase...
  22. Tonyali S, Haberal H, Yazici S, Erman M, Kaynaroglu Z, Bilen C. Survival following laparoscopic adrenalectomy for solitary metastasis of lung cancer. Int Urol Nephrol. 2016;48:1803-1809 pubmed
    To determine if L/S ADX is a safe and effective procedure for the management of solitary adrenal metastasis of lung cancer, and if it improves survival in lung cancer patients...
  23. Goto S, Ookawara S, Saito A. Differences in the adsorption of nafamostat mesilate between polyester-polymer alloy and polysulfone membranes. J Artif Organs. 2017;20:138-144 pubmed publisher
    ..In the present study, we evaluated differences in the adsorption of NM between a PEPA membrane (FDX-120 GW, Nikkiso, Tokyo, Japan) and two different polysulfone membranes (FX-140, Fresenius Medical Care, Tokyo, ..
  24. Ayyar V, Sukumaran S, Dubois D, Almon R, Qu J, Jusko W. Receptor/gene/protein-mediated signaling connects methylprednisolone exposure to metabolic and immune-related pharmacodynamic actions in liver. J Pharmacokinet Pharmacodyn. 2018;45:557-575 pubmed publisher
    ..relevant hepatic processes following a single dose of methylprednisolone (MPL) given to adrenalectomized (ADX) rats...
  25. Kang J, Lim D, Jung J. Energy-Efficient Forest Fire Prediction Model Based on Two-Stage Adaptive Duty-Cycled Hybrid X-MAC Protocol. Sensors (Basel). 2018;18: pubmed publisher
    This paper proposes an adaptive duty-cycled hybrid X-MAC (ADX-MAC) protocol for energy-efficient forest fire prediction...
  26. Linares C, Ferrín G, Aguilar Melero P, González Rubio S, Rodríguez Perálvarez M, Sánchez Aragó M, et al. Sensitivity to anti-Fas is independent of increased cathepsin D activity and adrenodoxin reductase expression occurring in NOS-3 overexpressing HepG2 cells. Biochim Biophys Acta. 2015;1853:1182-94 pubmed publisher
    ..In summary, NOS-3 overexpression resulted in an increased sensitivity to anti-Fas induced cell death, independently of AR expression and CatD activity. ..
  27. Wu C, Hou L, Ren S, Su B, Chen G. High feasibility of liquid-based cytological samples for detection of EGFR mutations in Chinese patients with NSCLC. Asian Pac J Cancer Prev. 2014;15:7885-9 pubmed
    ..Among them, 101 with diagnosis of lung adenocarcinoma had paired surgically resected specimens. The ADx Amplification Refractory Mutation System (ADx-ARMS) was used to determine EGFR mutation status both in LBC and ..
  28. Chen J, Wang Z, Zuo W, Zhang S, Chu S, Chen N. Effects of chronic mild stress on behavioral and neurobiological parameters - Role of glucocorticoid. Horm Behav. 2016;78:150-9 pubmed publisher
    ..anxiety-like behaviors manifest in the absence of glucocorticoid production and circulation in adrenalectomized (ADX) rats after chronic mild stress (CMS) exposure and its potential molecular mechanisms...
  29. Huhtaniemi R, Oksala R, Knuuttila M, Mehmood A, Aho E, Laajala T, et al. Adrenals Contribute to Growth of Castration-Resistant VCaP Prostate Cancer Xenografts. Am J Pathol. 2018;188:2890-2901 pubmed publisher
    ..ORX alone had no effect on serum P4 concentration, whereas orchectomized and adrenalectomized (ORX + ADX) resulted in a significant decrease in serum P4 and in a further reduction in the low levels of serum ..
  30. Yoo G, Bong J, Park M, Jose J, Kang M, Pyun J. Electrochemical analysis of autodisplayed adrenodoxin (Adx) on the outer membrane of E. coli. Biochim Biophys Acta. 2015;1848:1509-13 pubmed publisher
    In this work, adrenodoxin (Adx) was expressed on the outer membrane of E. coli by autodisplay and then the iron-sulfur cluster was incorporated into apo-Adx by an anaerobic reconstitution process...
  31. Sawyer A, Winkler M. Evolution of Chlamydomonas reinhardtii ferredoxins and their interactions with [FeFe]-hydrogenases. Photosynth Res. 2017;134:307-316 pubmed publisher
    ..In photosynthetic organisms, PETF, or ferredoxin 1 (FDX1), is the most studied ferredoxin due to its essential role in photosynthesis, where it transfers electrons from ..
  32. Ortega Ugalde S, de Koning C, Wallraven K, Bruyneel B, Vermeulen N, Grossmann T, et al. Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners. Appl Microbiol Biotechnol. 2018;102:9231-9242 pubmed publisher
    ..Two FNRs (FdrA and FprA) and five ferredoxins (Fdx, FdxA, FdxC, FdxD, and Rv1786) have been found in the Mtb genome...
  33. Woodruff E, Greenwood B, Chun L, Fardi S, Hinds L, Spencer R. Adrenal-dependent diurnal modulation of conditioned fear extinction learning. Behav Brain Res. 2015;286:249-55 pubmed publisher
    ..In a follow-up experiment, adrenalectomized (ADX) or sham surgery rats were similarly trained and tested across 3 separate daily sessions at either ZT4 or ZT16...
  34. Willemse E, De Vos A, Herries E, Andreasson U, Engelborghs S, van der Flier W, et al. Neurogranin as Cerebrospinal Fluid Biomarker for Alzheimer Disease: An Assay Comparison Study. Clin Chem. 2018;64:927-937 pubmed publisher
    ..The neurogranin Erenna® assay from Washington University, St. Louis, MO (WashU); ELISA from ADx Neurosciences; and ELISA from Gothenburg University, Mölndal, Sweden (UGot), were compared using silver staining ..
  35. Munoz J, Walker N, Scotto K, Rameshwar P. Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells. Cancer Lett. 2015;367:69-75 pubmed publisher
    ..Using an experimental model of Adriamycin-resistant DC3F cells (DC3F/Adx), we showed that increased P-gp caused TMZ resistance...
  36. Izumida H, Takagi H, Fujisawa H, Iwata N, Nakashima K, Takeuchi S, et al. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Exp Neurol. 2017;287:65-74 pubmed publisher
    Selective apoptosis of granule cells in the hippocampal dentate gyrus (DG) of rats with bilateral adrenalectomy (ADX) and in patients who died of adrenal insufficiency has been reported...
  37. Schiffer L, Anderko S, Hobler A, Hannemann F, Kagawa N, Bernhardt R. A recombinant CYP11B1 dependent Escherichia coli biocatalyst for selective cortisol production and optimization towards a preparative scale. Microb Cell Fact. 2015;14:25 pubmed publisher
    ..which are provided from NADPH via a redox chain, consisting of adrenodoxin reductase (AdR) and adrenodoxin (Adx)...
  38. Estrada D. The cytochrome P450 24A1 interaction with adrenodoxin relies on multiple recognition sites that vary among species. J Biol Chem. 2018;293:4167-4179 pubmed publisher
    ..function relies on formation of a P450-redox partner complex with the ferredoxin and electron donor adrenodoxin (Adx). However, very little is known about how the Adx-CYP24A1 complex forms...
  39. Nishiyama M, Uchida K, Abe N, Nozaki M. Molecular cloning of cytochrome P450 side-chain cleavage and changes in its mRNA expression during gonadal development of brown hagfish, Paramyxine atami. Gen Comp Endocrinol. 2015;212:1-9 pubmed publisher
    ..It is suggested that vertebrates, during their early evolution, have established the pituitary-gonadal reproductive system. ..
  40. Cornelius R, Wen D, Li H, Yuan Y, Wang France J, Warner P, et al. Low Na, high K diet and the role of aldosterone in BK-mediated K excretion. PLoS ONE. 2015;10:e0115515 pubmed publisher
    ..We subjected LNaHK mice to either sham surgery (sham), adrenalectomy (ADX) with low aldo replacement (ADX-LA), or ADX with high aldo replacement (ADX-HA)...
  41. Huang L, Lin J, Pan K, Huang C, Chu Y. Overexpressing Ferredoxins in Chlamydomonas reinhardtii Increase Starch and Oil Yields and Enhance Electric Power Production in a Photo Microbial Fuel Cell. Int J Mol Sci. 2015;16:19308-25 pubmed publisher
    Ferredoxins (FDX) are final electron carrier proteins in the plant photosynthetic pathway, and function as major electron donors in diverse redox-driven metabolic pathways...
  42. Miranda R, Torrezan R, de Oliveira J, Barella L, da Silva Franco C, Lisboa P, et al. HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats. J Endocrinol. 2016;230:27-38 pubmed publisher
    ..genesis of hypercorticosteronemia and hyperinsulinemia in an adult MSG-obese rat model, bilateral adrenalectomy (ADX) and subdiaphragmatic vagotomy (VAG) alone or combined surgeries (ADX-VAG) were performed...
  43. Huang G, Herbert J. Serotonin modulates the suppressive effects of corticosterone on proliferating progenitor cells in the dentate gyrus of the hippocampus in the adult rat. Neuropsychopharmacology. 2005;30:231-41 pubmed
    ..Adrenalectomized (ADX) rats with a replacement subcutaneous pellet of corticosterone showed reduced proliferation when given additional ..
  44. Muhsain S, Lang M, Abu Bakar A. Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress. Toxicol Appl Pharmacol. 2015;282:77-89 pubmed publisher
    ..The induced recruitment potentially confers membrane protection. ..
  45. McDougall A, Fosang A, Faggian J, Wallace M, Crossley K, Cole T, et al. Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung. Respir Res. 2018;19:155 pubmed publisher
    ..induce a pre-parturient-like rise in circulating cortisol, 2) fetal sheep at 143d GA bilaterally adrenalectomised (ADX) at 112d GA to remove endogenous cortisol and 3) fetal sheep at 124d GA in which bolus doses (2 × 11...
  46. Kobayashi M, Yasuoka Y, Sato Y, Zhou M, Abe H, Kawahara K, et al. Upregulation of calbindin D28k in the late distal tubules in the potassium-loaded adrenalectomized mouse kidney. Clin Exp Nephrol. 2011;15:355-362 pubmed publisher
    ..channel is an alternative K-secretory pathway in the apical membranes of the distal nephrons of adrenalectomized (ADX) animals...
  47. Talaber G, Tuckermann J, Okret S. ACTH controls thymocyte homeostasis independent of glucocorticoids. FASEB J. 2015;29:2526-34 pubmed publisher
    ..Here, we test this concept and report that ACTH directly controls thymic growth post-adrenalectomy (ADX) independent of the proapoptotic effect of GCs...
  48. Min H, Cha J, Kim K, Kim J, Ghee J, Kim H, et al. Renoprotective Effects of a Highly Selective A3 Adenosine Receptor Antagonist in a Mouse Model of Adriamycin-induced Nephropathy. J Korean Med Sci. 2016;31:1403-12 pubmed publisher
    ..The adriamycin (ADX)-induced nephropathy model induces podocyte injury, which results in severe proteinuria and progressive ..
  49. Xiong S, Wang Y, Yao M, Liu H, Zhou X, Xiao W, et al. Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation. Microb Cell Fact. 2017;16:105 pubmed publisher
    ..This study highlighted above described methods to obtain a high efficient and specific biocatalyst for the desired biotransformation. ..
  50. Rosenbrock H, Kramer G, Hobson S, Koros E, Grundl M, Grauert M, et al. Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator. Eur J Pharmacol. 2010;639:40-6 pubmed publisher
    ..functional interaction of mGlu(5) receptor and NMDA-receptor by the selective mGlu(5) receptor positive modulator ADX-47273 in-vitro and in-vivo...
  51. Khalil M, Bernhardt R, Hellwig P. Raman and infrared spectroscopic evidence for the structural changes of the 2Fe2S cluster and its environment during the interaction of adrenodoxin and adrenodoxin reductase. Spectrochim Acta A Mol Biomol Spectrosc. 2017;183:298-305 pubmed publisher
    ..In the present study, we investigated the interaction of two proteins involved in electron transfer, adrenodoxin (Adx) and adrenodoxin reductase (AdR) by using Raman and infrared spectroscopies...
  52. Feng W, Gu W, Zhao N, Pan Y, Luo W, Zhang H, et al. Comparison of the SuperARMS and Droplet Digital PCR for Detecting EGFR Mutation in ctDNA From NSCLC Patients. Transl Oncol. 2018;11:542-545 pubmed publisher
    ..The EGFR mutation status in tissue was tested by ADx-ARMS, matched plasma was detected by ddPCR and SuperARMS, respectively...
  53. Guillou S, Tamareille S, Giraud S, Poitevin G, Prunier Mirebeau D, Nguyen P, et al. Fondaparinux upregulates thrombomodulin and the endothelial protein C receptor during early-stage reperfusion in a rat model of myocardial infarction. Thromb Res. 2016;141:98-103 pubmed publisher
    Fondaparinux (FDX) was demonstrated to be cardioprotective in a rat model of myocardial ischemia reperfusion...
  54. Milczarek R, Sokołowska E, Rybakowska I, Kaletha K, Klimek J. Paraquat inhibits progesterone synthesis in human placental mitochondria. Placenta. 2016;43:41-6 pubmed publisher
    ..The action of PQ described here should be considered as potentially harmful for pregnancy and fetal development. ..
  55. Griffin A, Parajes S, Weger M, Zaucker A, Taylor A, O Neil D, et al. Ferredoxin 1b (Fdx1b) Is the Essential Mitochondrial Redox Partner for Cortisol Biosynthesis in Zebrafish. Endocrinology. 2016;157:1122-34 pubmed publisher
    Mitochondrial cytochrome P450 (CYP) enzymes rely on electron transfer from the redox partner ferredoxin 1 (FDX1) for catalytic activity. Key steps in steroidogenesis require mitochondrial CYP enzymes and FDX1...
  56. Ikeda M, Hojo Y, Komatsuzaki Y, Okamoto M, Kato A, Takeda T, et al. Hippocampal spine changes across the sleep-wake cycle: corticosterone and kinases. J Endocrinol. 2015;226:M13-27 pubmed publisher
    ..In adrenalectomized (ADX) rats, such a wake-induced increase of the spine density disappeared. S.c...
  57. Uchoa E, Rorato R, Ruginsk S, Borges B, Antunes Rodrigues J, Elias L. Corticotrophin-releasing factor receptor 2 mediates the enhanced activation of satiety-related responses through oxytocin neurons in the paraventricular nucleus of the hypothalamus after adrenalectomy. Neurosci Lett. 2015;606:123-8 pubmed publisher
    Adrenalectomy (ADX)-induced hypophagia is associated with increased activation of corticotrophin-releasing factor (CRF) and oxytocin (OT) neurons in the paraventricular nucleus of the hypothalamus (PVN) after refeeding...
  58. Woodruff E, Chun L, Hinds L, Spencer R. Diurnal Corticosterone Presence and Phase Modulate Clock Gene Expression in the Male Rat Prefrontal Cortex. Endocrinology. 2016;157:1522-34 pubmed publisher
    ..In experiment 1, rats were left adrenal-intact (sham) or were adrenalectomized (ADX) followed by 10 daily antiphasic (opposite time of day of the endogenous CORT peak) ip injections of either vehicle ..
  59. Przygodda F, Manfredi L, Machado J, Gonçalves D, Zanon N, Bonagamba L, et al. Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism. J Appl Physiol (1985). 2017;122:1114-1124 pubmed publisher
    ..Three-week-old rats were submitted to adrenalectomy (ADX) and exposed to 8 h of AIH (6% O2 for 40 s at 9-min intervals)...
  60. Boyaci H, Chen J, Lilic M, Palka M, Mooney R, Landick R, et al. Fidaxomicin jams Mycobacterium tuberculosis RNA polymerase motions needed for initiation via RbpA contacts. elife. 2018;7: pubmed publisher
    Fidaxomicin (Fdx) is an antimicrobial RNA polymerase (RNAP) inhibitor highly effective against Mycobacterium tuberculosis RNAP in vitro, but clinical use of Fdx is limited to treating Clostridium difficile intestinal ..
  61. Ogawa N, Kanki K, Honda K, Tomooka Y, Ryoke K, Watanabe T. Involvement of glucocorticoid in induction of lingual T1R3 in rodents. Eur J Pharmacol. 2015;761:262-7 pubmed publisher
    ..Both adrenal glands were removed from rats [adrenalectomized (ADX) rats] and T1R3 mRNA expression in fungiform papillae was examined by real-time RT-PCR...
  62. Gerber A, Kleser M, Biedendieck R, Bernhardt R, Hannemann F. Functionalized PHB granules provide the basis for the efficient side-chain cleavage of cholesterol and analogs in recombinant Bacillus megaterium. Microb Cell Fact. 2015;14:107 pubmed publisher
  63. Zhang X, Gurunathan S, Kim J. Effects of silver nanoparticles on neonatal testis development in mice. Int J Nanomedicine. 2015;10:6243-56 pubmed publisher
    ..The results of reverse transcription-quantitative polymerase chain reaction indicated that the E1f1ay, Gsta4, and Fdx1 genes were up-regulated, and the Amh, Cx43, and Claudin-11 genes were down-regulated in response to AgNPs exposure ..
  64. Oztürk A, Demirci N, Aktas Z, Demirag F, Alagöz A, Alici I, et al. EBUS may arise as an initial time saving procedure in patients who are suspected to have small cell lung cancer. Clin Respir J. 2016;: pubmed publisher
    ..between the first computed tomography (1stCT) and first diagnostic procedure (1stDP), 1stDP and final diagnosis (FDx), 1stCT and FDx, and 1stDP and EBUS procedure were also compared...
  65. Ehrhardt M, Gerber A, Hannemann F, Bernhardt R. Expression of human CYP27A1 in B. megaterium for the efficient hydroxylation of cholesterol, vitamin D3 and 7-dehydrocholesterol. J Biotechnol. 2016;218:34-40 pubmed publisher
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    Mammalian adrenodoxin (ferredoxin 1; Fdx1) is essential for the synthesis of various steroid hormones in adrenal glands...
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