Gene Symbol: FDPS
Description: farnesyl diphosphate synthase
Alias: FPPS, FPS, POROK9, farnesyl pyrophosphate synthase, (2E,6E)-farnesyl diphosphate synthase, FPP synthase, FPP synthetase, farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
Species: human
Products:     FDPS

Top Publications

  1. Bergstrom J, Bostedor R, Masarachia P, Reszka A, Rodan G. Alendronate is a specific, nanomolar inhibitor of farnesyl diphosphate synthase. Arch Biochem Biophys. 2000;373:231-41 pubmed
  2. Kavanagh K, Guo K, Dunford J, Wu X, Knapp S, Ebetino F, et al. The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A. 2006;103:7829-34 pubmed
    ..N-BPs), currently used as clinical inhibitors of bone-resorption diseases, target osteoclast farnesyl pyrophosphate synthase (FPPS) and inhibit protein prenylation...
  3. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
    ..family 51; DMEM: Dulbecco's modified Eagle's medium; Fabp5: fatty acid-binding protein 5; FBS: fetal bovine serum; Fdps: farnesyl diphosphate synthase; Glc: Glucose; HFD: high-fat diet; GO: gene ontology; HPRT: hypoxanthine guanine ..
  4. Yao L, Zhao H, Tang H, Liang J, Liu L, Dong H, et al. The receptor for advanced glycation end products is required for ?-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016;173:2600-13 pubmed publisher
    ..Inhibitors of RAGE, FPS-ZM1 and the RAGE antagonist peptide (RAP), were injected i.p. after each challenge...
  5. Schem C, Tower R, Kneissl P, Rambow A, Campbell G, Desel C, et al. Pharmacologically Inactive Bisphosphonates as an Alternative Strategy for Targeting Osteoclasts: In Vivo Assessment of 5-Fluorodeoxyuridine-Alendronate in a Preclinical Model of Breast Cancer Bone Metastases. J Bone Miner Res. 2017;32:536-548 pubmed publisher
    ..This unique class of drugs may offer distinct advantages in the setting of targeted adjuvant therapy and chemoprevention of bone diseases. © 2016 American Society for Bone and Mineral Research. ..
  6. Li Y, Wu S. Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway. Mol Cell Biochem. 2018;: pubmed publisher
    ..HMGCR, FDPS, SS, and ABCA1 expression increased, and ACAT2 expression noticeably reduced in SREBP-2+/+ transgenic ..
  7. Yang F, Wang Z, Zhang J, Tang J, Liu X, Tan L, et al. Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage. Stroke. 2015;46:1328-36 pubmed publisher
    ..after injury were examined in a rat model of ICH with or without administration of a RAGE-specific antagonist (FPS-ZM1). Autologous arterial blood was injected into the basal ganglia of rats to induce ICH...
  8. Efimova E, Ricco N, Labay E, Mauceri H, Flor A, Ramamurthy A, et al. HMG-CoA Reductase Inhibition Delays DNA Repair and Promotes Senescence After Tumor Irradiation. Mol Cancer Ther. 2018;17:407-418 pubmed publisher
    ..i>Mol Cancer Ther; 17(2); 407-18. ©2017 AACRSee all articles in this MCT Focus section, "Developmental Therapeutics in Radiation Oncology." ..
  9. Arbo M, Melega S, Stöber R, Schug M, Rempel E, Rahnenführer J, et al. Hepatotoxicity of piperazine designer drugs: up-regulation of key enzymes of cholesterol and lipid biosynthesis. Arch Toxicol. 2016;90:3045-3060 pubmed
    ..In conclusion, the present study shows that piperazine designer drugs act by up-regulating key enzymes of cholesterol biosynthesis which is likely to increase the risk of phospholipidosis and steatosis. ..

More Information

Publications146 found, 100 shown here

  1. Zameer S, Najmi A, Vohora D, Akhtar M. Bisphosphonates: Future perspective for neurological disorders. Pharmacol Rep. 2018;70:900-907 pubmed publisher
    ..well established role in attenuation of bone resorption and osteoclast apoptosis by inhibition of farnesyl pyrophosphate synthase enzyme (FPPS) in mevalonate pathway...
  2. Zofkova I, Nemcikova P, Kuklik M. Polymorphisms associated with low bone mass and high risk of atraumatic fracture. Physiol Res. 2015;64:621-31 pubmed
    ..Potential predictors of antiresorptive therapy efficacy include the following well established genes: ER, FDPS, Cyp19A1, VDR, Col1A1, and Col1A2, as well as the gene for the canonical (Wnt) pathway...
  3. Behura S, Sarro J, Li P, Mysore K, Severson D, Emrich S, et al. High-throughput cis-regulatory element discovery in the vector mosquito Aedes aegypti. BMC Genomics. 2016;17:341 pubmed publisher
    ..aegypti embryos revealed >121,000 FAIRE peaks (FPs), many of which clustered in the 1 kb 5' upstream flanking regions of genes known to be expressed at this stage...
  4. Ruangkittisakul A, Sharopov S, Kantor C, Kuribayashi J, Mildenberger E, Luhmann H, et al. Methylxanthine-evoked perturbation of spontaneous and evoked activities in isolated newborn rat hippocampal networks. Neuroscience. 2015;301:106-20 pubmed publisher
    ..on ENOs in CA3 neurons (CA3-ENOs) and CA3 electrical stimulation-evoked monosynaptic CA1 field potentials (CA1-FPs) in sliced and intact hippocampi, respectively, from 8 to 10-days-old rats...
  5. Sisler J, Chaput G, Sussman J, Ozokwelu E. Follow-up after treatment for breast cancer: Practical guide to survivorship care for family physicians. Can Fam Physician. 2016;62:805-811 pubmed
    To offer FPs a summary of evidence-based recommendations to guide their follow-up survivorship care of women treated for breast cancer...
  6. Healey G, Collier C, Griffin S, Schuberth H, Sandra O, Smith D, et al. Mevalonate Biosynthesis Intermediates Are Key Regulators of Innate Immunity in Bovine Endometritis. J Immunol. 2016;196:823-31 pubmed publisher
  7. Sakamoto K, Mizuta A, Fujimura K, Kurauchi Y, Mori A, Nakahara T, et al. High-mobility group Box-1 is involved in NMDA-induced retinal injury the in rat retina. Exp Eye Res. 2015;137:63-70 pubmed publisher
    ..receptor 2/4 antagonist peptide, receptor for advanced glycation end-products (RAGE) antagonist peptide, and FPS-ZM1 significantly reduced the retinal damage induced by HMGB1 protein...
  8. Yin R, Wang M, Huang Y, Landi G, Vecchio D, Chiang L, et al. Antimicrobial photodynamic inactivation with decacationic functionalized fullerenes: oxygen-independent photokilling in presence of azide and new mechanistic insights. Free Radic Biol Med. 2015;79:14-27 pubmed publisher
    ..LC15 was the most powerful broad spectrum antimicrobial fullerenyl photosensitizer (FPS) followed by LC16, and LC14 was least powerful...
  9. Lee H, Park J, Kim W, Sundar I, Rahman I, Park S, et al. Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling. FASEB J. 2017;31:2076-2089 pubmed publisher
    ..RAGE influences COPD in experimental COPD models, we investigated the efficacy of the RAGE-specific antagonist FPS-ZM1 administration in in vivo and in vitro COPD models...
  10. Andrade P, Caudepón D, Altabella T, Arró M, Ferrer A, Manzano D. Complex interplays between phytosterols and plastid development. Plant Signal Behav. 2017;12:e1387708 pubmed publisher
    ..However, the recent characterization of conditional knock-down mutant plants of farnesyl diphosphate synthase (FPS), a central enzyme in cytosolic and mitochondrial isoprenoid biosynthesis, revealed an unexpected role of this ..
  11. Teran Garcia M, Adamson A, Yu G, Rufo C, Suchankova G, Dreesen T, et al. Polyunsaturated fatty acid suppression of fatty acid synthase (FASN): evidence for dietary modulation of NF-Y binding to the Fasn promoter by SREBP-1c. Biochem J. 2007;402:591-600 pubmed
  12. Schuliga M. The inflammatory actions of coagulant and fibrinolytic proteases in disease. Mediators Inflamm. 2015;2015:437695 pubmed publisher
    ..enzymatic mediator of fibrinolysis, also forms toll-like receptor-4 (TLR-4) activating fibrin degradation products (FDPs) and can release latent-matrix bound growth factors such as transforming growth factor-β (TGF-β)...
  13. Osaki T, Souri M, Song Y, Izumi N, Law R, Ichinose A. Molecular pathogenesis of plasminogen Hakodate: the second Japanese family case of severe type I plasminogen deficiency manifested late-onset multi-organic chronic pseudomembranous mucositis. J Thromb Thrombolysis. 2016;42:218-24 pubmed publisher
    ..However, his plasma concentration of elastase-digested crosslinked FDPs was 4...
  14. Mahato D, Samanta D, Mukhopadhyay S, Krishnaraj R. A systems biology approach for elucidating the interaction of curcumin with Fanconi anemia FANC G protein and the key disease targets of leukemia. J Recept Signal Transduct Res. 2017;37:276-282 pubmed publisher
    ..The proteins namely DOT1L, farnesyl transferase (FDPS), histone decetylase (EP3000), Polo-like kinase (PLK-2), aurora-like kinase (AUKRB), tyrosine kinase (ABL1), and ..
    ..Such perturbations were abrogated with the concomitant treatment of inhibitors MIOX or RAGE (D-glucarate and FPS-ZM1)...
  16. Liao L, Zhuang X, Li W, Su Q, Zhao J, Liu Y. Polysaccharide from Fuzi protects against Ox?LDL?induced calcification of human vascular smooth muscle cells by increasing autophagic activity. Mol Med Rep. 2018;17:5109-5115 pubmed publisher
    Polysaccharide from Fuzi (FPS) is a water?soluble polysaccharide isolated from the traditional Chinese herbal medicine Fuzi...
  17. Holinka L, Largo E, Gladue D, O Donnell V, Risatti G, Nieva J, et al. Alteration of a Second Putative Fusion Peptide of Structural Glycoprotein E2 of Classical Swine Fever Virus Alters Virus Replication and Virulence in Swine. J Virol. 2016;90:10299-10308 pubmed
    ..These results provide the proof of principle to support as a strategy for vaccine development the discovery and manipulation of FPs.
  18. Li J, Liu S, Wang J, Li J, Liu D, Li J, et al. Fungal elicitors enhance ginsenosides biosynthesis, expression of functional genes as well as signal molecules accumulation in adventitious roots of Panax ginseng C. A. Mey. J Biotechnol. 2016;239:106-114 pubmed publisher
    ..significantly up-regulated the expression of the geranyl diphosphate synthase (GPS), farnesyl diphosphate synthase (FPS), squalene synthase (SS), squalene epoxidase (SE), dammarenediol synthase (DS), Two cytochrome P450 (CYP) genes (..
  19. Allahverdiyeva Y, Isojärvi J, Zhang P, Aro E. Cyanobacterial Oxygenic Photosynthesis is Protected by Flavodiiron Proteins. Life (Basel). 2015;5:716-43 pubmed publisher
    Flavodiiron proteins (FDPs, also called flavoproteins, Flvs) are modular enzymes widely present in Bacteria and Archaea...
  20. Portal C, Seifert J, Buehler C, Meisner Kober N, Auer M. Novel 1:1 labeling and purification process for C-terminal thioester and single cysteine recombinant proteins using generic peptidic toolbox reagents. Bioconjug Chem. 2014;25:1213-22 pubmed publisher
    ..While genetic tags such as fluorescent proteins (FPs) are widely used to detect proteins, FPs have several limitations compared to chemical tags...
  21. Hussain S, Singh A, Akhtar M, Najmi A. Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials. Rheumatol Int. 2017;37:1489-1498 pubmed publisher
    ..in Western Ontario and McMaster Universities (WOMAC) index, Visual Analog Scale (VAS) and Functional Pain Score (FPS) as the primary outcome measure...
  22. Alp G, Çakmak G, Sert M, Burgaz Y. Corrosion potential in artificial saliva and possible genotoxic and cytotoxic damage in buccal epithelial cells of patients who underwent Ni-Cr based porcelain-fused-to-metal fixed dental prostheses. Mutat Res. 2018;827:19-26 pubmed publisher
    ..based alloys account for the majority of the porcelain-fused-to-metal fixed dental prostheses(PFM-FDPs) on account of their superior properties despite both nickel and chromium being known as human carcinogens...
  23. Le Reste J, Nabbe P, Billot Grasset A, Le Floch B, Grall P, Derriennic J, et al. Multimorbid outpatients: A high frequency of FP appointments and/or family difficulties, should alert FPs to the possibility of death or acute hospitalization occurring within six months; A primary care feasibility study. PLoS ONE. 2017;12:e0186931 pubmed publisher
    ..hospitalization in a primary care cohort at a 6-month follow-up and to assess whether a large scale cohort with FPs would be feasible...
  24. Liu Y, Yu M, Zhang Z, YU Y, Chen Q, Zhang W, et al. Blockade of receptor for advanced glycation end products protects against systolic overload-induced heart failure after transverse aortic constriction in mice. Eur J Pharmacol. 2016;791:535-543 pubmed publisher
    ..Importantly, inhibition of RAGE by treatment with soluble RAGE (sRAGE) or FPS-ZM1 (a high-affinity RAGE-specific inhibitor) for 8 weeks attenuated cardiac remodeling (including cardiac ..
  25. Liu G, Yan G, Zhu B, Lu L. Design of a video capsule endoscopy system with low-power ASIC for monitoring gastrointestinal tract. Med Biol Eng Comput. 2016;54:1779-1791 pubmed
    ..multi-spectral imaging, including white light imaging and autofluorescence imaging, at a maximum frame rate of 24 fps and with a resolution of 400 × 400...
  26. Wu S, Han J, Liu R, Liu J, Lv H. A computational model for predicting fusion peptide of retroviruses. Comput Biol Chem. 2016;61:245-50 pubmed publisher
    ..of FP prediction software, it is urgent and desirable to develop a bioinformatics tool to predict new putative FPs (np-FPs) in retroviruses...
  27. Emmott A, West N, Zhou G, Dunsmuir D, Montgomery C, Lauder G, et al. Validity of Simplified Versus Standard Self-Report Measures of Pain Intensity in Preschool-Aged Children Undergoing Venipuncture. J Pain. 2017;18:564-573 pubmed publisher
    ..We aimed to evaluate the validity and feasibility of 2 novel simplified scales (Simplified Faces Pain Scale, S-FPS; Simplified Concrete Ordinal Scale, S-COS) for preschool-aged children...
  28. Shen C, Ma Y, Zeng Z, Yin Q, Hong Y, Hou X, et al. RAGE-Specific Inhibitor FPS-ZM1 Attenuates AGEs-Induced Neuroinflammation and Oxidative Stress in Rat Primary Microglia. Neurochem Res. 2017;42:2902-2911 pubmed publisher
    ..b>FPS-ZM1 is a high-affinity but nontoxic RAGE-specific inhibitor that has been recently shown to attenuate the A?-..
  29. Schraeder K, Brown J, Reid G. Perspectives on Monitoring Youth with Ongoing Mental Health Problems in Primary Health Care: Family Physicians Are "Out of the Loop". J Behav Health Serv Res. 2018;45:219-236 pubmed publisher
    ..For these youth, primary health care is highly relevant, as family physicians (FPs) are the only professionals who follow patients across the lifespan...
  30. Shinoda H, Ma Y, Nakashima R, Sakurai K, Matsuda T, Nagai T. Acid-Tolerant Monomeric GFP from Olindias formosa. Cell Chem Biol. 2018;25:330-338.e7 pubmed publisher
    ..However, most FPs lose fluorescence at a pH lower than their neutral pKa (∼6), and this has hampered their ..
  31. de Carvalho M, Swash M. Fasciculation discharge frequency in amyotrophic lateral sclerosis and related disorders. Clin Neurophysiol. 2016;127:2257-62 pubmed publisher
    ..To address this issue, we studied the variation of fasciculation potential (FPs) frequency as evaluated by surface electromyography of the first dorsal interosseous muscle (1st DI) in patients ..
  32. Amsalingam R, Gajjeraman P, Sam N, Rahman V, Azariah B. Mechanism of Fenpropathrin Resistance in Red Spider Mite, Oligonychus coffeae (Acarina: Tetranychidae), Infesting Tea [Camellia sinensis L. (O. Kuntze)]. Appl Biochem Biotechnol. 2017;181:548-561 pubmed publisher
    ..O. Kuntze)]. The development of acaricide (fenpropathrin) resistance has been screened in field populations (FPs) of RSMs from different tea-growing regions of south India and compared with a laboratory-susceptible population (..
  33. Frank T, Krieger A, Léonard S, Patel N, Tokuda J. ROS-IGTL-Bridge: an open network interface for image-guided therapy using the ROS environment. Int J Comput Assist Radiol Surg. 2017;12:1451-1460 pubmed publisher
    ..Performance tests demonstrated that the bridge could stream transforms, strings, points, and images at 30 fps in both directions successfully. The data transfer latency was <1...
  34. Feng S, Sekine S, Pessino V, Li H, Leonetti M, Huang B. Improved split fluorescent proteins for endogenous protein labeling. Nat Commun. 2017;8:370 pubmed publisher
    Self-complementing split fluorescent proteins (FPs) have been widely used for protein labeling, visualization of subcellular protein localization, and detection of cell-cell contact...
  35. Zambiazzi E, Bruzi A, Sales A, Borges I, Guilherme S, Zuffo A, et al. Genetic diversity in soybean genotypes using phenotypic characters and enzymatic markers. Genet Mol Res. 2017;16: pubmed publisher
    ..0%. To obtain six different groups, individually discriminating the cultivars CG 8166 RR, FPS Jupiter RR, and BRS MG 780 RR, enzymatic markers were used...
  36. Yilmaz B, Alshahrani F, Kale E, Johnston W. Effect of feldspathic porcelain layering on the marginal fit of zirconia and titanium complete-arch fixed implant-supported frameworks. J Prosthet Dent. 2018;120:71-78 pubmed publisher
    ..regarding the precision of fit of CAD-CAM-fabricated implant-supported complete zirconia fixed dental prostheses (FDPs) before and after porcelain layering are limited...
  37. Kosaka K, Iwatani A, Takeichi Y, Yoshikawa Y, Ohkubo K, Akiba M. Removal of haloacetamides and their precursors at water purification plants applying ozone/biological activated carbon treatment. Chemosphere. 2018;198:68-74 pubmed publisher
    ..The profiles of six HAcAms and their formation potentials (FPs) upon chlorination at water purification plant 1 (WPP-1) in September 2016 and at WPP-2 in September 2016 and ..
  38. Nesse H, Ulstein D, Vaage M, Øilo M. Internal and marginal fit of cobalt-chromium fixed dental prostheses fabricated with 3 different techniques. J Prosthet Dent. 2015;114:686-92 pubmed publisher
    ..of conventional casting, milling, and SLM differ in internal and marginal fit for Co-Cr fixed dental prostheses (FDPs)...
  39. Amaral M, Villefort R, Melo R, Pereira G, Zhang Y, Valandro L, et al. Fatigue limit of monolithic Y-TZP three-unit-fixed dental prostheses: Effect of grinding at the gingival zone of the connector. J Mech Behav Biomed Mater. 2017;72:159-162 pubmed publisher
    To determine the fatigue limits of three-unit monolithic zirconia fixed dental prosthesis (FDPs) before and after grinding of the gingival areas of connectors with diamond burs...
  40. Finseth F, Harrison R. Genes Integral to the Reproductive Function of Male Reproductive Tissues Drive Heterogeneity in Evolutionary Rates in Japanese Quail. G3 (Bethesda). 2018;8:39-51 pubmed publisher
    ..i> wintering conditions for both tissues and (2) genes that encode foam proteins (FPs) vs. those with varying degrees of expression specificity in the FG. We report two major findings...
  41. Luck Sikorski C, Schomerus G, Jochum T, Riedel Heller S. Layered stigma? Co-occurring depression and obesity in the public eye. J Psychosom Res. 2018;106:29-33 pubmed publisher
    ..differentials based on previous stigma research of depression (depression stigma DS) and obesity (Fat Phobia Scale FPS). Personal experience with depression and obesity was assessed...
  42. Liu H, Wang J, Zhang Q, Zhang H. The effect of different substitute groups and molecular weights of fucoidan on neuroprotective and anticomplement activity. Int J Biol Macromol. 2018;113:82-89 pubmed publisher
    Ten fucoidan (FPS) derivatives were successfully synthesized, and their potential neuroprotective and anticomplement activities were investigated employing various established in vitro systems...
  43. Jagannadh V, Bhat B, Nirupa Julius L, Gorthi S. High-throughput miniaturized microfluidic microscopy with radially parallelized channel geometry. Anal Bioanal Chem. 2016;408:1909-16 pubmed publisher
    ..hundred and twenty five thousand cells per minute), even while employing cost-effective low frame rate cameras (120 fps)...
  44. Nie K, Wang X, Qiao J, Xu J. A Full Parallel Event Driven Readout Technique for Area Array SPAD FLIM Image Sensors. Sensors (Basel). 2016;16:160 pubmed publisher
    ..The readout frame rate is 10 Mfps, and the maximum imaging frame rate is 100 fps. The chip's output bandwidth is 720 MHz with an average power of 15 mW...
  45. Bruyns Haylett M, Luo J, Kennerley A, Harris S, Boorman L, Milne E, et al. The neurogenesis of P1 and N1: A concurrent EEG/LFP study. Neuroimage. 2017;146:575-588 pubmed publisher
    ..respect to excitation observed in intracellular recordings is also reflected in extracellular field potentials (FPs), resulting in a temporal window during which only excitatory post-synaptic activity and leak channel activity are ..
  46. Gossett J, Sammet C, Agrawal A, Rychlik K, Wax D. Reducing Fluoroscopic Radiation Exposure During Endomyocardial Biopsy in Pediatric Transplant Recipients. Pediatr Cardiol. 2017;38:308-313 pubmed publisher
    ..We undertook a quality initiative reducing frame rate from 10 frames per second (FPS) to 5 FPS...
  47. Ammann J, Hartmann C, Siegrist M. Development and validation of the Food Disgust Picture Scale. Appetite. 2018;125:367-379 pubmed publisher
    The present set of studies developed and tested the Food Disgust Picture Scale (FDPS). This is a tool for the assessment of food disgust sensitivity that will measure disgust and predict possible reactions...
  48. Kuruoglu E, Guldal D, Mevsim V, Gunvar T. Which family physician should I choose? The analytic hierarchy process approach for ranking of criteria in the selection of a family physician. BMC Med Inform Decis Mak. 2015;15:63 pubmed publisher
    ..Selection criteria for choosing a FP were put in a priority order by using AHP model. These criteria can be used as measures for selecting alternative FPs in further researches.
  49. Bei E, Shu Y, Li S, Liao X, Wang J, Zhang X, et al. Occurrence of nitrosamines and their precursors in drinking water systems around mainland China. Water Res. 2016;98:168-75 pubmed publisher
    ..The average NDMA concentration in finished and tap waters was 11 and 13 ng/L, respectively. Formation potentials (FPs) of source waters were examined with an average NDMA FP of 66 ng/L...
  50. Hou S, Tian T, Qi D, Sun K, Yuan Q, Wang Z, et al. S100A4 promotes lung tumor development through β-catenin pathway-mediated autophagy inhibition. Cell Death Dis. 2018;9:277 pubmed publisher
    ..abolished in A549 and LLC cells using the receptor for advanced glycation end products (RAGE)-specific inhibitor (FPS-ZM1). S100A4-deficient mice showed retarded tumor development...
  51. Das S, Edwards P, Crockett J, Rogers M. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochim Biophys Acta. 2014;1841:569-73 pubmed publisher
    ..N-BPs inactivate osteoclasts via inhibition of farnesyl diphosphate synthase (FPPS), thereby preventing the prenylation of essential small GTPases...
  52. Bajar B, Wang E, Lam A, Kim B, Jacobs C, Howe E, et al. Improving brightness and photostability of green and red fluorescent proteins for live cell imaging and FRET reporting. Sci Rep. 2016;6:20889 pubmed publisher
    ..While pairs of cyan and yellow fluorescent proteins (FPs) are most commonly used as FRET partner fluorophores, respectively, green and red FPs offer distinct advantages for ..
  53. Sorrentino R, Di Mauro M, Ferrari M, Leone R, Zarone F. Complications of endodontically treated teeth restored with fiber posts and single crowns or fixed dental prostheses-a systematic review. Clin Oral Investig. 2016;20:1449-57 pubmed publisher
    ..in endodontically treated teeth restored with fiber posts and single crowns (SCs) or fixed dental prostheses (FDPs)...
  54. Chu J, Haynes R, Corbel S, Li P, González González E, Burg J, et al. Non-invasive intravital imaging of cellular differentiation with a bright red-excitable fluorescent protein. Nat Methods. 2014;11:572-8 pubmed publisher
    ..Imaging of fluorescent proteins (FPs) using red excitation light in the 'optical window' above 600 nm is one potential method for visualizing implanted ..
  55. Good D, George T, Watts B. High-mobility group box 1 inhibits HCO(3)(-) absorption in medullary thick ascending limb through a basolateral receptor for advanced glycation end products pathway. Am J Physiol Renal Physiol. 2015;309:F720-30 pubmed publisher
    ..Inhibition by HMGB1 was eliminated by the receptor for advanced glycation end products (RAGE) antagonist FPS-ZM1 and by neutralizing anti-RAGE antibody...
  56. Feng W, Zhang F, Qu X, Zheng S. Per-Pixel Coded Exposure for High-Speed and High-Resolution Imaging Using a Digital Micromirror Device Camera. Sensors (Basel). 2016;16: pubmed publisher
    ..We demonstrate the effectiveness of our method via extensive examples and achieve 100 fps (frames per second) gain in temporal resolution by using a 25 fps camera.
  57. Campos Outcalt D. 8 USPSTF recommendations FPs need to know about. J Fam Pract. 2016;65:338-41 pubmed
    ..Treat high blood pressure only if measurements taken outside of the office confirm an initial high BP reading · Screen blood-glucose levels in overweight/obese individuals 40 to 70 years old · and more. ..
  58. Caldwell B, Ustione A, Piston D. Dopamine Receptor Signaling in MIN6 ?-Cells Revealed by Fluorescence Fluctuation Spectroscopy. Biophys J. 2016;111:609-618 pubmed publisher
    ..each labeled with a different-colored fluorescent protein (FP), yielded plasma membrane expression of all three FPs and permitted an FFS evaluation of interactions between the dopamine receptors and the G?? complex...
  59. Hurley L, Lindley M, Allison M, Crane L, Brtnikova M, Beaty B, et al. Primary care physicians' perspective on financial issues and adult immunization in the Era of the Affordable Care Act. Vaccine. 2017;35:647-654 pubmed publisher
    ..We administered an Internet and mail survey from June to October 2013 to national networks of 438 GIMs and 401 FPs. Response rates were 72% (317/438) for GIM and 59% (236/401) for FP...
  60. Díaz Serrano K, Dias T, Vasconcelos P, Sousa L, Siéssere S, Regalo S, et al. Impact of temporomandibular disorders on the stomatognathic system in children. Med Oral Patol Oral Cir Bucal. 2017;22:e723-e729 pubmed publisher
    ..8 years; 22 boys and 23 girls) were examined on the basis of the RDC/TMD and the Faces Pain Scale-Revised (FPS-R) was used to determine the level of severity of the signs and symptoms of TMD, resulting in four groups: GI - ..
  61. Piazzoli A, Breider F, Aquillon C, Antonelli M, von Gunten U. Specific and total N-nitrosamines formation potentials of nitrogenous micropollutants during chloramination. Water Res. 2018;135:311-321 pubmed publisher
    ..05% (N,N-dimethylbenzyl amine), very similar to the molar TONO yields. The comparison of the FPs of micropollutants and model compounds showed that the presence of electron donating functional groups (such as a ..
  62. Jiang G, Liu L, Zhu W, Yin S, Wei S. A 181 GOPS AKAZE Accelerator Employing Discrete-Time Cellular Neural Networks for Real-Time Feature Extraction. Sensors (Basel). 2015;15:22509-29 pubmed publisher
    ..The experimental results show a performance of 127 fps in full HD resolution at 200 MHz frequency...
  63. Tian X, Ruan J, Huang J, Fang X, Mao Y, Wang L, et al. Gossypol: phytoalexin of cotton. Sci China Life Sci. 2016;59:122-9 pubmed publisher
    ..characterized, including 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) and farnesyl diphosphate synthase (FPS) that catalyze the formation of the precursor farnesyl diphosphate (FPP), (+)-δ-cadinene synthase (CDN) which is ..
  64. Adona P, Leal C, Biase F, De Bem T, Mesquita L, Meirelles F, et al. In vitro maturation alters gene expression in bovine oocytes. Zygote. 2016;24:624-33 pubmed publisher
    ..differential expression between in vivo- and in vitro-matured oocytes (EZR, EPN1, PSEN2, FST, IGFBP3, RBBP4, STAT3, FDPS and IRS1)...
  65. Bhattacharya A, Watts N, Dwivedi A, Shukla R, Mani A, Diab D. Combined Measures of Dynamic Bone Quality and Postural Balance--A Fracture Risk Assessment Approach in Osteoporosis. J Clin Densitom. 2016;19:154-64 pubmed publisher
    ..integrity were quantified with a noninvasive measure of static and dynamic functional postural stability (FPS), and fracture resistance was obtained with bone shock absorption in patients with osteoporosis aged 65-85 and ..
  66. Gruchattka E, Kayser O. In Vivo Validation of In Silico Predicted Metabolic Engineering Strategies in Yeast: Disruption of α-Ketoglutarate Dehydrogenase and Expression of ATP-Citrate Lyase for Terpenoid Production. PLoS ONE. 2015;10:e0144981 pubmed publisher
    ..Main sites of regulation need to be released and improved enzymes are essential to meet the required activities for an increased product formation in vivo. ..
  67. Anchieta R, Machado L, Hirata R, Coelho P, Bonfante E. Survival and failure modes: platform-switching for internal and external hexagon cemented fixed dental prostheses. Eur J Oral Sci. 2016;124:490-497 pubmed publisher
    This study evaluated the probability of survival (reliability) of platform-switched fixed dental prostheses (FDPs) cemented on different implant-abutment connection designs...
  68. Dangol S, Singh R, Chen Y, Jwa N. Visualization of Multicolored in vivo Organelle Markers for Co-Localization Studies in Oryza sativa. Mol Cells. 2017;: pubmed publisher
    ..golgi body, endoplasmic reticulum, plasma membrane, and tonoplast, with four different fluorescent proteins (FPs) (G3GFP, mRFP, YFP, and CFP)...
  69. Keats M, Shea K, Parker L, Stewart S, Flanders A, Bernstein M. After Childhood Cancer: a Qualitative Study of Family Physician, Parent/Guardian, and Survivor Information Needs and Perspectives on Long-Term Follow-up and Survivorship Care Plans. J Cancer Educ. 2018;: pubmed publisher
    ..conducted semi-structured telephone interviews with a purposefully selected sample of CCS, parents/guardians, and FPs. Data included responses to stakeholder cancer care information needs, concerns with or gaps in communication, the ..
  70. Salazar Varas R, Costa Ã, Iáñez E, Úbeda A, Hortal E, Azorín J. Analyzing EEG signals to detect unexpected obstacles during walking. J Neuroeng Rehabil. 2015;12:101 pubmed publisher
    ..The results of the best subject were 11 out of 14 obstacles detected with a rate of 9.09 FPs/min, and 10 out of 14 obstacles detected with a rate of 6...
  71. Khmelinskii A, Meurer M, Ho C, Besenbeck B, Füller J, Lemberg M, et al. Incomplete proteasomal degradation of green fluorescent proteins in the context of tandem fluorescent protein timers. Mol Biol Cell. 2016;27:360-70 pubmed publisher
    ..Each tFT, composed of two fluorescent proteins (FPs) that differ in maturation kinetics, is suited to follow protein dynamics within a specific time range determined ..
  72. Kang H, Lee S, Lee E, Kim S, Lee T. Real-time GPU-accelerated processing and volumetric display for wide-field laser-scanning optical-resolution photoacoustic microscopy. Biomed Opt Express. 2015;6:4650-60 pubmed publisher
    ..The average total GPU processing time for a B-mode PAM image was approximately 1.35 ms at a display speed of 480 fps when the data samples were acquired with 736 (axial) × 500 (lateral) points/B-mode-frame at a pulse repetition ..
  73. Di Paolo D, Afanzar O, Armitage J, Berry R. Single-molecule imaging of electroporated dye-labelled CheY in live Escherichia coli. Philos Trans R Soc Lond B Biol Sci. 2016;371: pubmed publisher
    For the past two decades, the use of genetically fused fluorescent proteins (FPs) has greatly contributed to the study of chemotactic signalling in Escherichia coli including the activation of the response regulator protein CheY and its ..
  74. Popek M, Bobula B, Sowa J, Hess G, Polowy R, Filipkowski R, et al. Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events. Mol Neurobiol. 2018;55:1244-1258 pubmed publisher
    ..a set of electrophysiological correlates of impaired transmitter release including decreased field potentials (FPs), increased paired-pulse facilitation (PPF), and decreased frequency of spontaneous and miniature excitatory ..
  75. Yamaguchi T, Wada H, Miyazaki S, Hasegawa M, Wakabayashi H, Asanuma K, et al. Fibrin-related markers for diagnosing acute-, subclinical-, and pre-venous thromboembolism in patients with major orthopedic surgery. Int J Hematol. 2016;103:560-6 pubmed publisher
    ..markers (FRMs), such as D-dimer, soluble fibrin (SF), and fibrinogen and fibrin degradation products (FDPs) in 66 patients with acute-phase VTE, and 367 patients undergoing major orthopedic surgery...
  76. Qiu L, Yang H, Lv G, Li K, Liu G, Wang W, et al. Insights into the mevalonate pathway in the anticancer effect of a platinum complex on human gastric cancer cells. Eur J Pharmacol. 2017;810:120-127 pubmed publisher
    ..gastric cancer cells SGC7901 were investigated systematically, since inhibition of the key enzyme farnesyl pyrophosphate synthase (FPPS) in the mevalonate pathway was acknowledged as the mechanism of most anticancer actions of the ..
  77. Birgiolas J, Jernigan C, Gerkin R, Smith B, Crook S. SwarmSight: Real-time Tracking of Insect Antenna Movements and Proboscis Extension Reflex Using a Common Preparation and Conventional Hardware. J Vis Exp. 2017;: pubmed publisher
    ..frames about 120 times faster than humans, performs at better than human accuracy, and, using 30 frames per second (fps) videos, can capture antennal dynamics up to 15 Hz...
  78. Woelber J, Ratka Krueger P, Vach K, Frisch E. Decementation Rates and the Peri-Implant Tissue Status of Implant-Supported Fixed Restorations Retained via Zinc Oxide Cement: A Retrospective 10-23-Year Study. Clin Implant Dent Relat Res. 2016;18:917-925 pubmed publisher
    ..Decementation was assessed in 57 implants supporting 30 SCs and 16 FDPs. Five cases of decementation (8.77%) were recorded after a mean of 9.27 ± 7.05 years (range: 4...
  79. Ohnuma S, Hirooka K, Ohto C, Nishino T. Conversion from archaeal geranylgeranyl diphosphate synthase to farnesyl diphosphate synthase. Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity. J Biol Chem. 1997;272:5192-8 pubmed
    ..Although FPP synthase and GGPP synthase catalyze similar consecutive condensations of isopentenyl diphosphate with allylic ..
  80. Thompson K, Dunford J, Ebetino F, Rogers M. Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun. 2002;290:869-73 pubmed
  81. Notarnicola M, Messa C, Cavallini A, Bifulco M, Tecce M, Eletto D, et al. Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis. Oncology. 2004;67:351-8 pubmed
    Farnesyl diphosphate synthase (FPPs) produces FPP which is considered a branch-point intermediate in the synthesis of sterols and isoprenylated cellular metabolites...
  82. Ory B, Moriceau G, Trichet V, Blanchard F, Berreur M, Redini F, et al. Farnesyl diphosphate synthase is involved in the resistance to zoledronic acid of osteosarcoma cells. J Cell Mol Med. 2008;12:928-41 pubmed publisher
    ..that this resistance could be associated with a differential expression of farnesyl diphos-phate synthase (FPPS) also observed in human osteosarcoma samples...
  83. Ng J, Shih B. Level of visual acuity necessary to avoid false-positives on the HRR and Ishihara color vision tests. Eur J Ophthalmol. 2017;27:363-366 pubmed publisher
    Minimizing false-positives (FPs) when evaluating color vision is important in eye care. Identification of plate 1 (demonstration plate) is often considered a way to avoid FPs...
    ..uniglandular disease by an endocrinologist-performed ultrasound (US) in patients with discordant or negative technetium-sestamibi scans and to evaluate whether this procedure increases the number of focused parathyroidectomies (FPs).
  85. Mori S. Deep architecture neural network-based real-time image processing for image-guided radiotherapy. Phys Med. 2017;40:79-87 pubmed publisher
    ..convolutions with a pair of pooling and upsampling layers achieved real-time processing at 30 frames per second (fps) with acceptable image quality...
  86. Zhang L, Capilla A, Song W, Mostoslavsky G, Yi J. Oblique scanning laser microscopy for simultaneously volumetric structural and molecular imaging using only one raster scan. Sci Rep. 2017;7:8591 pubmed publisher
    ..5??m in OCT in three dimensions, and the current speed of imaging is up to 100 frames per second (fps) over a volume about 0.8?×?1?×?0.5?mm3...
  87. Lopez Suarez C, Rodriguez V, Pelaez J, Agustin Panadero R, Suárez M. Comparative fracture behavior of monolithic and veneered zirconia posterior fixed dental prostheses. Dent Mater J. 2017;36:816-821 pubmed publisher
    ..the fracture load and the fracture pattern of monolithic and veneered zirconia posterior fixed dental prostheses (FDPs). Twenty standardized steel dies were prepared to receive posterior 3-unit FDPs...
  88. Bae J, Kim I, Nam K. Disruption of the hydrogen bonding network determines the pH-induced non-fluorescent state of the fluorescent protein ZsYellow by protonation of Glu221. Biochem Biophys Res Commun. 2017;493:562-567 pubmed publisher
    Many fluorescent proteins (FPs) exhibit fluorescence quenching at a low pH. This pH-induced non-fluorescent state of an FP serves as a useful indicator of the cellular pH...
  89. Dutra R, Dantas A, Marques D, Batista J, Meireles B, de Magalhães Cordeiro Â, et al. Bioaccessibility and antioxidant activity of phenolic compounds in frozen pulps of Brazilian exotic fruits exposed to simulated gastrointestinal conditions. Food Res Int. 2017;100:650-657 pubmed publisher
    This study characterized the phenolic profile in siriguela, umbu-cajá and mangaba, as well in their frozen pulps (FPs)...
  90. Ismail O, Antonelli M, Ciogli A, Villani C, Cavazzini A, Catani M, et al. Future perspectives in high efficient and ultrafast chiral liquid chromatography through zwitterionic teicoplanin-based 2-?m superficially porous particles. J Chromatogr A. 2017;1520:91-102 pubmed publisher
    ..7?m SPPs and 1.9?m Fully Porous Particles (FPPs)...
  91. Zhang W, Ma L, Xiao H, Liu C, Chen L, Wu S, et al. Identification and characterization of genes involving the early step of Juvenile Hormone pathway in Helicoverpa armigera. Sci Rep. 2017;7:16542 pubmed publisher
    ..Altogether, these results contribute to our understanding of JH biosynthesis in H. armigera and provide target genes for pest control based on JH-dependent regulation. ..
  92. Ding V, Sheares B, Bergstrom J, Ponpipom M, Perez L, Poulter C. Purification and characterization of recombinant human farnesyl diphosphate synthase expressed in Escherichia coli. Biochem J. 1991;275 ( Pt 1):61-5 pubmed
    ..5.1.10) and the expression of an active FPP synthase fusion protein in Escherichia coli...