FCN2

Summary

Gene Symbol: FCN2
Description: ficolin 2
Alias: EBP-37, FCNL, P35, ficolin-2, ficolin-2, 37 kDa elastin-binding protein, L-ficolin, collagen/fibrinogen domain-containing protein 2, ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), ficolin B, ficolin-beta, serum lectin p35
Species: human
Products:     FCN2

Top Publications

  1. Chapman S, Vannberg F, Khor C, Segal S, Moore C, Knox K, et al. Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease. Mol Immunol. 2007;44:3267-70 pubmed
    ..Five common functional polymorphisms have recently been identified in the FCN2 gene which encodes L-ficolin: three promoter polymorphisms (at positions -986, -602 and -4) which affect serum L-..
  2. Liu J, Ali M, Shi Y, Zhao Y, Luo F, Yu J, et al. Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation. Cell Mol Immunol. 2009;6:235-44 pubmed publisher
    ..These findings provide new insights into the biological functions of L-ficolin in clinically important hepatic viral diseases. ..
  3. Messias Reason I, Schafranski M, Kremsner P, Kun J. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. Clin Exp Immunol. 2009;157:395-9 pubmed publisher
    ..Here we investigated polymorphisms in the promoter region of the FCN2 gene (at positions -986/-602 and +4) in 122 patients with RF and CRHD and in 210 healthy subjects from the same ..
  4. Ma Y, Doni A, Hummelshøj T, Honore C, Bastone A, Mantovani A, et al. Synergy between ficolin-2 and pentraxin 3 boosts innate immune recognition and complement deposition. J Biol Chem. 2009;284:28263-75 pubmed publisher
    ..fumigatus was enhanced by PTX3. A polymorphism in the FCN2 gene causing a T236M amino acid change in the fibrinogen-like binding domain of Ficolin-2, which affects the ..
  5. de Rooij B, van Hoek B, ten Hove W, Roos A, Bouwman L, Schaapherder A, et al. Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. Hepatology. 2010;52:1100-10 pubmed publisher
    ..Single-nucleotide polymorphisms in the mannose-binding lectin gene (MBL2), the ficolin-2 gene (FCN2), and the MBL-associated serine protease gene (MASP2) of recipients and donors were determined...
  6. Ruskamp J, Hoekstra M, Postma D, Kerkhof M, Bottema R, Koppelman G, et al. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. Clin Exp Immunol. 2009;155:433-40 pubmed publisher
    ..We investigated the association between variation in genes encoding Ficolin-2 (FCN2) and Ficolin-3 (FCN3) and frequency of RTI during the first 4 years of life...
  7. Lacroix M, Dumestre Pérard C, Schoehn G, Houen G, Cesbron J, Arlaud G, et al. Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. J Immunol. 2009;182:456-65 pubmed
  8. Krarup A, Mitchell D, Sim R. Recognition of acetylated oligosaccharides by human L-ficolin. Immunol Lett. 2008;118:152-6 pubmed publisher
    ..Few of these bound L-ficolin above background level but clear structural requirements were discovered. ..
  9. Faik I, Oyedeji S, Idris Z, de Messias Reason I, Lell B, Kremsner P, et al. Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria. Hum Immunol. 2011;72:74-9 pubmed publisher
    Human ficolin-2 (L-ficolin; FCN2) is a serum protein binding to sugar moieties of different human micro-pathogens forcing phagocytosis...

More Information

Publications91

  1. de Rooij B, van der Beek M, van Hoek B, Vossen A, Rogier Ten Hove W, Roos A, et al. Mannose-binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation. J Hepatol. 2011;55:800-7 pubmed publisher
    ..OLT patients (n = 295) were genotyped for recipient and donor SNPs in mannose-binding lectin (MBL2), Ficolin-2 (FCN2) and MBL-associated serine protease (MASP2) genes. Combined analysis of independently associated variant MBL2 [HR 1...
  2. Munthe Fog L, Hummelshøj T, Hansen B, Koch C, Madsen H, Skjødt K, et al. The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels. Scand J Immunol. 2007;65:383-92 pubmed
    Ficolin-2 (L-ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition molecule found in human serum in which inter-individual variation in serum appears to be under genetic control...
  3. Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, et al. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007;26:623-33 pubmed
  4. Chen X, Katoh Y, Nakamura K, Oyama N, Kaneko F, Endo Y, et al. Single nucleotide polymorphisms of Ficolin 2 gene in Behçet's disease. J Dermatol Sci. 2006;43:201-5 pubmed
    ..b>Ficolin 2 is a lectin that binds to the surface of microbial cells and kills microbial cells through the activation of ..
  5. Kuraya M, Ming Z, Liu X, Matsushita M, Fujita T. Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology. 2005;209:689-97 pubmed
    ..Thus, L-ficolin and H-ficolin as well as MBL participate in the clearance of apoptotic cells through complement activation. ..
  6. Krarup A, Thiel S, Hansen A, Fujita T, Jensenius J. L-ficolin is a pattern recognition molecule specific for acetyl groups. J Biol Chem. 2004;279:47513-9 pubmed
    ..The column was loaded in the presence of EDTA and high salt, and L-ficolin was eluted by decreasing the salt concentration. Further purification was achieved by ion exchange chromatography. ..
  7. Ojurongbe O, Ouf E, Van Tong H, Toan N, Song L, Luz P, et al. Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns. BMC Med Genet. 2012;13:37 pubmed
    Ficolin-2 coded by FCN2 gene is a soluble serum protein and an innate immune recognition element of the complement system...
  8. Matsushita M, Endo Y, Taira S, Sato Y, Fujita T, Ichikawa N, et al. A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. J Biol Chem. 1996;271:2448-54 pubmed
    ..We report here a novel Ca(2+)-dependent and GlcNAc-binding lectin consisting of subunits of 35 kDa (P35) with a collagen-like sequence...
  9. Ouf E, Ojurongbe O, Akindele A, Sina Agbaje O, Van Tong H, Adeyeba A, et al. Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis. J Infect Dis. 2012;206:562-70 pubmed publisher
    Human ficolin-2 (L-ficolins) encoded by the FCN2 gene are pattern-recognition proteins involved in innate immunity and are associated with several infectious diseases.
  10. Szala A, St Swierzko A, Cedzynski M. Cost-effective procedures for genotyping of human FCN2 gene single nucleotide polymorphisms. Immunogenetics. 2013;65:439-46 pubmed publisher
    ..and sugar binding capacity are influenced by single nucleotide polymorphisms (SNP) of the corresponding FCN2 gene...
  11. Endo Y, Sato Y, Matsushita M, Fujita T. Cloning and characterization of the human lectin P35 gene and its related gene. Genomics. 1996;36:515-21 pubmed
    We previously cloned a novel human lectin, designated P35, with both collagen-like and fibrinogen-like domains. P35 recognizes GlcNAc residues and is opsonic toward microorganisms...
  12. Hoang T, Toan N, Song L, Ouf E, Bock C, Kremsner P, et al. Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients. PLoS ONE. 2011;6:e28113 pubmed publisher
    Human Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver...
  13. Assaf A, Hoang T, Faik I, Aebischer T, Kremsner P, Kun J, et al. Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis. PLoS ONE. 2012;7:e34113 pubmed publisher
    Ficolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association with cutaneous leishmaniasis...
  14. Meijvis S, Herpers B, Endeman H, de Jong B, van Hannen E, van Velzen Blad H, et al. Mannose-binding lectin (MBL2) and ficolin-2 (FCN2) polymorphisms in patients on peritoneal dialysis with staphylococcal peritonitis. Nephrol Dial Transplant. 2011;26:1042-5 pubmed publisher
    ..Single-nucleotide polymorphisms (SNPs) in the MBL2 and FCN2 genes influence the functionality of the proteins...
  15. Hu Y, Luo F, Fu J, Chen T, Wu S, Zhou Y, et al. Early increased ficolin-2 concentrations are associated with severity of liver inflammation and efficacy of anti-viral therapy in chronic hepatitis C patients. Scand J Immunol. 2013;77:144-50 pubmed publisher
    ..05), while in non-RVR group, ficolin-2 decreased slightly (P > 0.05). Our findings suggest that early increased ficolin-2 is highly correlated with hepatic inflammation and rapid viral response. ..
  16. de Messias Reason I, Kremsner P, Kun J. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. J Infect Dis. 2009;199:801-4 pubmed
    ..Here, we analyze polymorphisms of the gene encoding ficolin-2 (FCN2), which is a soluble pattern-recognition molecule...
  17. Kilpatrick D, Fujita T, Matsushita M. P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients. Immunol Lett. 1999;67:109-12 pubmed
    b>P35 (L-ficolin) is a novel calcium-dependent lectin which may have a role in innate immunity. The concentration range of P35 in blood donor sera was found to be 1.1-12.8 (median 3.7) microg/ml, with most values below 6.0 microg/ml...
  18. Taira S, Kodama N, Matsushita M, Fujita T. Opsonic function and concentration of human serum ficolin/P35. Fukushima J Med Sci. 2000;46:13-23 pubmed
    ..We previously described an N-acetylglucosamine (GlcNAc)-binding lectin (ficolin/P35) with a collagen- and a fibrinogen-like sequence present in human serum...
  19. Herpers B, Immink M, de Jong B, van Velzen Blad H, de Jongh B, van Hannen E. Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors. Mol Immunol. 2006;43:851-5 pubmed
    ..Structural polymorphisms in the MBL2 gene lead to functional deficiency of MBL. Polymorphisms in the FCN2 gene have not been studied previously...
  20. Cedzynski M, Nuytinck L, Atkinson A, St Swierzko A, Zeman K, Szemraj J, et al. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. Clin Exp Immunol. 2007;150:99-104 pubmed
    ..It activates the lectin pathway of complement and acts as an opsonin. l-ficolin, encoded by the FCN2 gene, recognizes microbial polysaccharides and glycoconjugates rich in GlcNAc or GalNAc...
  21. Vander Cruyssen B, Nuytinck L, Boullart L, Elewaut D, Waegeman W, Van Thielen M, et al. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. Rheumatology (Oxford). 2007;46:1792-5 pubmed
    ..Two SNPs in the FCN1 gene, four SNPs in the FCN2 gene and one SNP in the FCN3 gene were studied...
  22. Swierzko A, Atkinson A, Cedzynski M, MacDonald S, Szala A, Domzalska Popadiuk I, et al. Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. Mol Immunol. 2009;46:551-8 pubmed publisher
    ..Some similar trends were found with facets of MBL deficiency, but the observed relationships were weaker and less consistent. ..
  23. Cedzynski M, Atkinson A, St Swierzko A, MacDonald S, Szala A, Zeman K, et al. L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. Mol Immunol. 2009;47:415-9 pubmed publisher
    ..MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease. ..
  24. Czapski G, GÄ…ssowska M, Wilkaniec A, Chalimoniuk M, Strosznajder J, Adamczyk A. The mechanisms regulating cyclin-dependent kinase 5 in hippocampus during systemic inflammatory response: The effect on inflammatory gene expression. Neurochem Int. 2016;93:103-12 pubmed publisher
    ..Also transcription of Cdk5-regulatory protein (p35/Cdk5r1) was augmented, and the level of p25, calpain-dependent cleavage product of p35, was increased...
  25. Austin S, Katusic Z. Loss of Endothelial Nitric Oxide Synthase Promotes p25 Generation and Tau Phosphorylation in a Murine Model of Alzheimer's Disease. Circ Res. 2016;119:1128-1134 pubmed
    ..Brain tissue from eNOS-/- mice had statistically higher ratios of p25/p35, indicative of increased cyclin-dependent kinase 5 activity as compared with wild-type (n=8, P<0.05)...
  26. Liu C, Zhai X, Zhao B, Wang Y, Xu Z. Cyclin I-like (CCNI2) is a cyclin-dependent kinase 5 (CDK5) activator and is involved in cell cycle regulation. Sci Rep. 2017;7:40979 pubmed publisher
    ..The kinase activity of CDK5 is tightly regulated by specific activators including p35, p39, and cyclin I (CCNI)...
  27. Akhter N, Takeda Y, Nara H, Araki A, Ishii N, Asao N, et al. Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses. J Biol Chem. 2016;291:23672-23680 pubmed
    ..On the other hand, E3330 up-regulated the IL-12 p35 and p40 gene expression, and IL-12 surface retention, but decreased the IL-12 secretion from Toll-like receptor (..
  28. Demyanenko S, Uzdensky A. Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex. Mol Neurobiol. 2017;54:6839-6856 pubmed publisher
    ..Following proteins regulating actin cytoskeleton were over-expressed: cofilin, actopaxin, p120CTN, ?-catenin, p35, myosin Va, and pFAK were up-regulated, whereas ezrin, tropomyosin, spectrin (? + ?), ?IV-tubulin and ..
  29. Horvath Z, Csuka D, Vargova K, Lee S, Varga L, Garred P, et al. Association of Low Ficolin-Lectin Pathway Parameters with Cardiac Syndrome X. Scand J Immunol. 2016;84:174-81 pubmed publisher
    ..Complement activation through the ficolin-lectin pathway might play a role in the complex pathomechanism of CSX. ..
  30. Shupp A, Casimiro M, Pestell R. Biological functions of CDK5 and potential CDK5 targeted clinical treatments. Oncotarget. 2017;8:17373-17382 pubmed publisher
    ..While it was previously thought that CDK5 only interacted with p35 or p39 and their cleaved counterparts, Recent evidence suggests that CDK5 can interact with certain cylins, amongst ..
  31. Luz P, Boldt A, Grisbach C, Kun J, Velavan T, Messias Reason I. Association of L-ficolin levels and FCN2 genotypes with chronic Chagas disease. PLoS ONE. 2013;8:e60237 pubmed publisher
    L-ficolin (encoded by FCN2) binds to acetylated sugar moieties of many pathogens, including Trypanosoma cruzi, promoting their phagocytosis and lysis by the complement system.
  32. Feng X, Hou H, Zou Y, Guo L. Defective autophagy is associated with neuronal injury in a mouse model of multiple sclerosis. Bosn J Basic Med Sci. 2017;17:95-103 pubmed publisher
    ..an in vivo model of MS, was induced in female C57BL/6 mice by immunization with myelin oligodendrocyte glycoprotein p35-55...
  33. Jusko M, Potempa J, Mizgalska D, Bielecka E, Ksiazek M, Riesbeck K, et al. A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System. J Immunol. 2015;195:2231-40 pubmed publisher
    ..forsythia and expand the knowledge on molecular mechanisms driving pathogenic events in the infected periodontium. ..
  34. Imamura E, Taguchi K, Sasaki Iwaoka H, Kubo S, Furukawa S, Morokata T. Anti-IL-23 receptor monoclonal antibody prevents CD4+ T cell-mediated colitis in association with decreased systemic Th1 and Th17 responses. Eur J Pharmacol. 2018;824:163-169 pubmed publisher
    ..Previous studies have identified the roles of IL-12 and IL-23 using mice deficient for their specific subunits, p35 and p19, respectively...
  35. Bai X, Hou X, Tian J, Geng J, Li X. CDK5 promotes renal tubulointerstitial fibrosis in diabetic nephropathy via ERK1/2/PPAR? pathway. Oncotarget. 2016;7:36510-36528 pubmed publisher
    ..In late staged DN patients, the upregulation of CDK5 and p35 activated phosphorylated ERK1/2 and PPAR?, leading to decreased levels of E-cadherin but increased Vimentin and ..
  36. Mishra A, Antony J, Sundaravadivel P, Tong H, Meyer C, Jalli R, et al. Association of Ficolin-2 Serum Levels and FCN2 Genetic Variants with Indian Visceral Leishmaniasis. PLoS ONE. 2015;10:e0125940 pubmed publisher
    ..We have estimated ficolin-2 serum levels and analyzed the functional variants of the encoding gene FCN2 in 218 cases of VL and in 225 controls from an endemic region of India...
  37. Fransen J, Pangeni G, Pyle I, McCall M. Functional changes in Tg P23H-1 rat retinal responses: differences between ON and OFF pathway transmission to the superior colliculus. J Neurophysiol. 2015;114:2368-75 pubmed publisher
    ..transgenic (Tg) P23H-1 rats, a model of retinitis pigmentosa (RP), and wild-type (WT) rats at postnatal days 35-50 (P35-50) and P300...
  38. Badin A, Morrill P, Devonshire I, Greenfield S. (II) Physiological profiling of an endogenous peptide in the basal forebrain: Age-related bioactivity and blockade with a novel modulator. Neuropharmacology. 2016;105:47-60 pubmed publisher
    ..brain (p14 rats) exhibiting more conspicuous assemblies over space and time compared to their older counterparts (p35-40 rats)...
  39. Geno K, Kennedy R, Sawyer P, Brown C, Nahm M. Ficolin-2 inhibitors are present in sera after prolonged storage at -80 °C. Peerj. 2016;4:e2705 pubmed
    ..Furthermore, noninhibiting samples and fresh sera from older adults had apparently normal amounts of ficolin-2. Thus, ficolin-2 inhibitors may arise as an artifact of long-term storage of serum at -80 °C. ..
  40. Hansen M. Biomarkers of Necrotising Soft Tissue Infections Aspects of the Innate Immune Response. Dan Med J. 2017;64: pubmed
    ..Through the three studies we have identified relevant biomarkers that are useful in the risk stratification of patients with NSTI, thus perhaps enhancing prognostication and decision making in these critically ill patients. ..
  41. Bihaqi S, Bahmani A, Adem A, Zawia N. Infantile postnatal exposure to lead (Pb) enhances tau expression in the cerebral cortex of aged mice: relevance to AD. Neurotoxicology. 2014;44:114-20 pubmed publisher
    ..Mice with developmental Pb exposure also displayed altered protein ratio of p35/p25 with more Serine/Threonine phosphatase activity at old age...
  42. Sokolova O, Chemeris A, Guo S, Alioto S, Gandhi M, PADRICK S, et al. Structural Basis of Arp2/3 Complex Inhibition by GMF, Coronin, and Arpin. J Mol Biol. 2017;429:237-248 pubmed publisher
    ..open conformation of Arp2/3 complex, with the N-terminal ?-propeller domain of Coronin positioned near the p35/ARPC2 subunit of Arp2/3 complex...
  43. Halmos A, Rigo J, Szijártó J, Fust G, Prohaszka Z, Molvarec A. Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia. Clin Exp Immunol. 2012;169:49-56 pubmed publisher
  44. Won J, Annamalai B, Choi S, Singh I, Singh A. S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion. Brain Res. 2015;1624:359-69 pubmed publisher
    ..GSNO attenuated the increased calpain activities and calpain-mediated cleavage of p35 leading to production of p25 and aberrant Cdk5 activation...
  45. Böhme J, Roßnagel C, Jacobs T, Behrends J, Hölscher C, Erdmann H. Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation. Immunology. 2016;147:338-48 pubmed publisher
    ..related to the subunit p40 of IL-12 and forms a heterodimer either with the p28 subunit to build IL-27 or with p35 to form IL-35...
  46. Gout E, Moriscot C, Doni A, Dumestre Pérard C, Lacroix M, Perard J, et al. M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J Immunol. 2011;186:5815-22 pubmed publisher
    ..The M-ficolin-PTX3 interaction described in this study represents a novel case of cross-talk between soluble pattern-recognition molecules, lending further credit to the integrated view of humoral innate immunity that emerged recently. ..
  47. Ding Q, Shen Y, Li D, Yang J, Yu J, Yin Z, et al. Ficolin-2 triggers antitumor effect by activating macrophages and CD8+ T cells. Clin Immunol. 2017;183:145-157 pubmed publisher
    ..Our findings provide a new therapeutic strategy for tumors based on the triggering of immune-mediated antitumor effect by ficolin-2. ..
  48. Saito T, Matsuba Y, Yamazaki N, Hashimoto S, Saido T. Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression. J Neurosci. 2016;36:9933-6 pubmed publisher
    Intraneuronal calcium stimulates the calpain-dependent conversion of p35 to p25, a CDK5 activator...
  49. Matsumoto M, Hayashi K, Suetake H, Yamamoto A, Araki K. Identification and functional characterization of multiple interleukin 12 in amberjack (Seriola dumerili). Fish Shellfish Immunol. 2016;55:281-92 pubmed publisher
    ..seriolae stimulation but not by formalin-killed N. seriolae, suggesting that four types of IL-12 (p35, p35b, p40a and p40c) participate in promoting CMI...
  50. Spurrier J, Shukla A, McLinden K, Johnson K, Giniger E. Altered expression of the Cdk5 activator-like protein, Cdk5α, causes neurodegeneration, in part by accelerating the rate of aging. Dis Model Mech. 2018;11: pubmed publisher
    ..of the activating subunit of the Cdk5 protein kinase, encoded by the gene Cdk5α, the ortholog of mammalian p35. Cdk5α-mediated degeneration was associated with a 27-150% acceleration of the intrinsic rate of aging, ..
  51. Kudo H, Wang Z, Jinnin M, Nakayama W, Inoue K, Honda N, et al. EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin. J Immunol. 2015;195:3565-73 pubmed publisher
    ..IL-35 consists of p35 and EBI3 subunits, and EBI3 alone could downregulate the protein and mRNA expression of type I or type III collagen ..
  52. Luo F, Sun X, Wang Y, Wang Q, Wu Y, Pan Q, et al. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS ONE. 2013;8:e73859 pubmed publisher
    Human ficolin-2 (ficolin-2/P35) is a lectin complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during ..
  53. Cseh S, Vera L, Matsushita M, Fujita T, Arlaud G, Thielens N. Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J Immunol. 2002;169:5735-43 pubmed
    ..It has been reported recently that L-ficolin/P35 associates with mannan-binding lectin (MBL)-associated serine proteases (MASP-1 and -2) and MBL-associated protein ..
  54. Fu X, Duan W, Su C, Mao F, Lv Y, Teng Y, et al. Interleukin 6 induces M2 macrophage differentiation by STAT3 activation that correlates with gastric cancer progression. Cancer Immunol Immunother. 2017;66:1597-1608 pubmed publisher
    ..data indicate that IL-6 induces M2 macrophage differentiation (IL-10highTGF-?highIL-12 p35low ) by activating STAT3 phosphorylation, and the IL-6-induced M2 macrophages exert a pro-tumor ..
  55. Cui B, Liu W, Wang X, Chen Y, Du Q, Zhao X, et al. Brucella Omp25 Upregulates miR-155, miR-21-5p, and miR-23b to Inhibit Interleukin-12 Production via Modulation of Programmed Death-1 Signaling in Human Monocyte/Macrophages. Front Immunol. 2017;8:708 pubmed publisher
    ..of Omp25 protein inhibited TLR agonists-induced IL-12 p70 production through suppression of both IL-12 p40 and p35 subunit expression in THP-1 cells...
  56. Wang J, Saul A, Cui X, Roon P, Smith S. Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2017;58:4545-4558 pubmed publisher
    ..rd10/Sig1R-/- mice had 35% and 60% fewer photoreceptors, respectively, at P28 and P35, than rd10...
  57. Luo F, Chen T, Liu J, Shen X, Zhao Y, Yang R, et al. Ficolin-2 binds to HIV-1 gp120 and blocks viral infection. Virol Sin. 2016;31:406-414 pubmed
    ..To our knowledge, this is the first report about the protective role of ficolin-2 against HIV-1 infection and our study suggests that ficolin-2 is an important human innate immune molecule against HIV. ..
  58. Hein E, Munthe Fog L, Thiara A, Fiane A, Mollnes T, Garred P. Heparin-coated cardiopulmonary bypass circuits selectively deplete the pattern recognition molecule ficolin-2 of the lectin complement pathway in vivo. Clin Exp Immunol. 2015;179:294-9 pubmed publisher
    ..These findings may have implications for the postoperative susceptibility to infections in patients undergoing extracorporeal circulation procedures. ..
  59. Zhao Y, Ren Y, Zhang X, Zhao P, Tao W, Zhong J, et al. Ficolin-2 inhibits hepatitis C virus infection, whereas apolipoprotein E3 mediates viral immune escape. J Immunol. 2014;193:783-96 pubmed publisher
    Human ficolin-2 (L-ficolin/p35) is a lectin-complement pathway activator that is present in normal human plasma and is associated with infectious diseases; however, little is known regarding the roles and mechanisms of ficolin-2 during ..
  60. Sun D, Gao L, Jin L, Wu H, Wang Q, Zhou Y, et al. Fluoxetine administration during adolescence attenuates cognitive and synaptic deficits in adult 3×TgAD mice. Neuropharmacology. 2017;126:200-212 pubmed publisher
    ..FLX was applied through peritoneal injection to the mice at postnatal day 35 (p35) for 15 consecutive days, and the effects of FLX were observed at 6-month...
  61. Sakamaki J, Fu A, Reeks C, Baird S, Depatie C, Al Azzabi M, et al. Role of the SIK2-p35-PJA2 complex in pancreatic β-cell functional compensation. Nat Cell Biol. 2014;16:234-44 pubmed publisher
    ..Here we delineate a complex consisting of the AMPK-related kinase SIK2, the CDK5 activator CDK5R1 (also known as p35) and the E3 ligase PJA2 essential for β-cell functional compensation...
  62. Erkan A, Oz I, Terzi Y, Aydin E, Ozkale M, Babakurban S, et al. FCN2 c.772G>T polymorphism is associated with chronic adenoiditis and/or tonsillitis, but not -4 A>G and -602 G>A. Int J Pediatr Otorhinolaryngol. 2016;87:1-4 pubmed publisher
    ..In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the ficolin 2 gene (FCN2) and chronic adenotonsillitis in pediatric cases. Case-control study...
  63. Osthoff M, Dean M, Baird P, Richardson A, Daniell M, Guymer R, et al. Association Study of Mannose-Binding Lectin Levels and Genetic Variants in Lectin Pathway Proteins with Susceptibility to Age-Related Macular Degeneration: A Case-Control Study. PLoS ONE. 2015;10:e0134107 pubmed publisher
    ..MBL levels and single nucleotide polymorphisms (SNPs) in the MBL2 and the ficolin-2 (FCN2) gene were determined in 109 patients with AMD and 109 age- and sex-matched controls...
  64. Fields J, Metcalf J, OVERK C, Adame A, Spencer B, Wrasidlo W, et al. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. J Neurovirol. 2017;23:290-303 pubmed publisher
    ..Moreover, in these animals, sunitinib reduced the hyperactivation of CDK5, tau hyperphosphorylation, and p35 cleavage to p25...
  65. Eikmans M, De Canck I, van der Pol P, Baan C, Haasnoot G, Mallat M, et al. The functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predicts improved renal transplant outcome. Transplantation. 2012;94:478-85 pubmed
  66. Watanabe H, Saito R, Asano T, Sato S, Iwadate H, Kobayashi H, et al. Serum L-ficolin levels in patients with systemic lupus erythematosus. Mod Rheumatol. 2012;22:899-902 pubmed publisher
    ..008). There were no correlations between serum L-ficolin levels and SLEDAI, serum C3, or serum C4 levels. The association between L-ficolin and thrombocytopenia suggests a pathogenic role for L-ficolin in thrombocytopenia in SLE. ..
  67. Ohashi T, Erickson H. The disulfide bonding pattern in ficolin multimers. J Biol Chem. 2004;279:6534-9 pubmed
    ..We present a model in which symmetric Cys24-Cys24 disulfide bonds between trimers are the basis for multimerization. The model may also be relevant to collectin multimers. ..
  68. Lazenka M, Kang M, De D, Selley D, Sim Selley L. ?9-Tetrahydrocannabinol Experience Influences ?FosB and Downstream Gene Expression in Prefrontal Cortex. Cannabis Cannabinoid Res. 2017;2:224-234 pubmed publisher
    ..of repeated THC treatment increased expression of cyclin-dependent kinase 5 (Cdk5) and its regulatory protein p35 only in the PFC...
  69. Ehrnström B, Beckwith K, Yurchenko M, Moen S, Kojen J, Lentini G, et al. Toll-Like Receptor 8 Is a Major Sensor of Group B Streptococcus But Not Escherichia coli in Human Primary Monocytes and Macrophages. Front Immunol. 2017;8:1243 pubmed publisher
    ..Gene silencing of MDM using siRNA revealed that GBS-induced IFN?, IL-12-p35, and TNF production was dependent on TLR8 and IRF5. In contrast, cytokine induction by E...
  70. Tanio M, Kondo S, Sugio S, Kohno T. Overexpression, purification and preliminary crystallographic analysis of human M-ficolin fibrinogen-like domain. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006;62:652-5 pubmed
    ..45, c = 55.19 angstroms, beta = 99.88 degrees, and contain three molecules per asymmetric unit. An X-ray data set was collected to 1.9 angstroms resolution using synchrotron radiation at beamline BL24XU at the SPring-8 facility in Japan. ..
  71. Ali M, Mali V, Haddox S, AbdelGhany S, El Deek S, Abulfadl A, et al. Essential Role of IL-12 in Angiogenesis in Type 2 Diabetes. Am J Pathol. 2017;187:2590-2601 pubmed publisher
    ..To induce type 2 diabetes, wild-type (WT), p40IL-12-/- (p40-/-), and p35IL-12-/- (p35-/-) mice were fed a high-fat diet (HFD) for 12 weeks...
  72. Zhang D, Huang X, Wang D, Li Y, Yao Y. Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China. Hum Genet. 2013;132:629-40 pubmed publisher
    ..We aimed to examine whether genetic variants of the Ficolin-2 (FCN2), Mannose-binding lectin (MBL2) and Complement factor H (CFH) genes, which are involved in activation and ..
  73. Gamage A, Lee K, Gan Y. Anti-Cancer Drug HMBA Acts as an Adjuvant during Intracellular Bacterial Infections by Inducing Type I IFN through STING. J Immunol. 2017;199:2491-2502 pubmed publisher
    ..infection partly via the induction of type I IFN in these cells, which primed an increased transcription of the p35 subunit of IL-12p70 during infection...
  74. Soares R, Horiquini Barbosa E, Almeida S, Lachat J. Environmental enrichment protects spatial learning and hippocampal neurons from the long-lasting effects of protein malnutrition early in life. Behav Brain Res. 2017;335:55-62 pubmed publisher
    ..changes in the hippocampus of adult rats maintained on a protein deficient diet during brain development (P0-P35)...
  75. Yousuf M, Tan C, Torres Altoro M, Lu F, Plautz E, Zhang S, et al. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. J Neurochem. 2016;138:317-27 pubmed publisher
    ..Cdk5 is a neuronal protein kinase activated via interaction with its cofactor p35 that regulates numerous neuronal functions, including synaptic remodeling and cognition...
  76. van Kempen G, Meijvis S, Endeman H, Vlaminckx B, Meek B, de Jong B, et al. Mannose-binding lectin and l-ficolin polymorphisms in patients with community-acquired pneumonia caused by intracellular pathogens. Immunology. 2017;151:81-88 pubmed publisher
    ..Dutch patients with CAP and 227 control participants we studied whether polymorphisms in the MBL (MBL2) and FCN (FCN2) genes influenced susceptibility and outcome...
  77. Tanha N, Pilely K, Faurschou M, Garred P, Jacobsen S. Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus. Clin Rheumatol. 2017;36:335-341 pubmed publisher
    ..Low plasma ficolin-2 levels were associated with an increased risk of having LN. High plasma levels of ficolin-1 were associated with the histological subtype of LN and development of ESRD. ..
  78. Brady A, Calix J, Yu J, Geno K, Cutter G, Nahm M. Low invasiveness of pneumococcal serotype 11A is linked to ficolin-2 recognition of O-acetylated capsule epitopes and lectin complement pathway activation. J Infect Dis. 2014;210:1155-65 pubmed publisher
    ..Ficolin-2 mediates serum protection by recognizing specific O-acetylated epitopes of pneumococcal capsule polysaccharides, exemplifying a novel host-microbe interaction that innately offers serotype-specific immunity to IPD. ..
  79. Hamed M, Brown R, Zothner C, Urbanowicz R, Mason C, Krarup A, et al. Recombinant human L-ficolin directly neutralizes hepatitis C virus entry. J Innate Immun. 2014;6:676-84 pubmed publisher
    ..This is the first description of direct neutralization of HCV entry by a ficolin and highlights a novel role for L-ficolin as a virus entry inhibitor. ..
  80. FIELDS J, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, et al. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Curr HIV Res. 2015;13:43-54 pubmed
    ..CDK5 is activated by binding to its regulatory subunit, p35 or p39...
  81. Pilely K, Rosbjerg A, Genster N, Gal P, Pal G, Halvorsen B, et al. Cholesterol Crystals Activate the Lectin Complement Pathway via Ficolin-2 and Mannose-Binding Lectin: Implications for the Progression of Atherosclerosis. J Immunol. 2016;196:5064-74 pubmed publisher
    ..In conclusion, our study demonstrates that PRMs from the lectin pathway recognize CC and provides evidence for an important role for this pathway in the inflammatory response induced by CC in the pathophysiology of atherosclerosis. ..
  82. Yang G, Liang Y, Zheng T, Song R, Wang J, Shi H, et al. FCN2 inhibits epithelial-mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-?/Smad signaling. Cancer Lett. 2016;378:80-6 pubmed publisher
    ..In this study, we find Ficolin-2 (FCN2) plays an essential role in metastasis and EMT of HCC. FCN2 expression is downregulated in HCC cells and tissues...