FCGRT

Summary

Gene Symbol: FCGRT
Description: Fc fragment of IgG receptor and transporter
Alias: FCRN, alpha-chain, IgG receptor FcRn large subunit p51, Fc fragment of IgG, receptor, transporter, alpha, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, heavy chain of the major histocompatibility complex class I-like Fc receptor, immunoglobulin receptor, intestinal, heavy chain, major histocompatibility complex class I-like Fc receptor, neonatal Fc receptor, neonatal Fc-receptor for Ig, transmembrane alpha chain of the neonatal receptor
Species: human
Products:     FCGRT

Top Publications

  1. Goebl N, Babbey C, Datta Mannan A, Witcher D, Wroblewski V, Dunn K. Neonatal Fc receptor mediates internalization of Fc in transfected human endothelial cells. Mol Biol Cell. 2008;19:5490-505 pubmed publisher
    The neonatal Fc receptor, FcRn mediates an endocytic salvage pathway that prevents degradation of IgG, thus contributing to the homeostasis of circulating IgG...
  2. Kliwinski C, Cooper P, Perkinson R, Mabus J, Tam S, Wilkinson T, et al. Contribution of FcRn binding to intestinal uptake of IgG in suckling rat pups and human FcRn-transgenic mice. Am J Physiol Gastrointest Liver Physiol. 2013;304:G262-70 pubmed publisher
    Immunoglobulin G (IgG) is transcytosed across intestinal epithelial cells of suckling mammals by the neonatal Fc receptor (FcRn); however, the contribution of FcRn vs...
  3. Ebel W, Routhier E, Foley B, Jacob S, McDonough J, Patel R, et al. Preclinical evaluation of MORAb-003, a humanized monoclonal antibody antagonizing folate receptor-alpha. Cancer Immun. 2007;7:6 pubmed
    ..Because of its multimodal activity in vitro and its safe toxicology profile in non-human primates, MORAb-003 development has recently been advanced to clinical trials involving ovarian cancer patients. ..
  4. Wani M, Haynes L, Kim J, Bronson C, Chaudhury C, Mohanty S, et al. Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene. Proc Natl Acad Sci U S A. 2006;103:5084-9 pubmed
    ..deficient in both albumin and IgG because of rapid degradation of these proteins, suggesting a lack of the neonatal Fc receptor, FcRn...
  5. Prabhat P, Gan Z, Chao J, Ram S, Vaccaro C, Gibbons S, et al. Elucidation of intracellular recycling pathways leading to exocytosis of the Fc receptor, FcRn, by using multifocal plane microscopy. Proc Natl Acad Sci U S A. 2007;104:5889-94 pubmed
    ..intracellular events on the recycling pathway that lead to exocytosis of the MHC Class I-related receptor, FcRn. We observe both direct delivery of tubular and vesicular transport containers (TCs) from sorting endosomes to ..
  6. Zhou J, Mateos F, Ober R, Ward E. Conferring the binding properties of the mouse MHC class I-related receptor, FcRn, onto the human ortholog by sequential rounds of site-directed mutagenesis. J Mol Biol. 2005;345:1071-81 pubmed
    The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells...
  7. Claypool S, Dickinson B, Wagner J, Johansen F, Venu N, Borawski J, et al. Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor. Mol Biol Cell. 2004;15:1746-59 pubmed
    The human MHC class I-related neonatal Fc receptor, hFcRn, mediates bidirectional transport of IgG across mucosal barriers...
  8. Qiao S, Kobayashi K, Johansen F, Sollid L, Andersen J, Milford E, et al. Dependence of antibody-mediated presentation of antigen on FcRn. Proc Natl Acad Sci U S A. 2008;105:9337-42 pubmed publisher
    The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes...
  9. Andersen J, Justesen S, Fleckenstein B, Michaelsen T, Berntzen G, Kenanova V, et al. Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues. FEBS J. 2008;275:4097-110 pubmed publisher
    The neonatal Fc receptor (FcRn) is a major histocompatibility complex class I-related molecule that regulates the half-life of IgG and albumin...

More Information

Publications94

  1. West A, Bjorkman P. Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,). Biochemistry. 2000;39:9698-708 pubmed
    The neonatal Fc receptor (FcRn) performs two distinct but related functions: transport of maternal immunoglobulin G (IgG) to pre- or neonatal mammals, thus providing passive immunity, and protection of IgG from normal serum protein ..
  2. Tzaban S, Massol R, Yen E, Hamman W, Frank S, Lapierre L, et al. The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol. 2009;185:673-84 pubmed publisher
    The Fc receptor FcRn traffics immunoglobulin G (IgG) in both directions across polarized epithelial cells that line mucosal surfaces, contributing to host defense...
  3. Mezo A, Sridhar V, Badger J, Sakorafas P, Nienaber V. X-ray crystal structures of monomeric and dimeric peptide inhibitors in complex with the human neonatal Fc receptor, FcRn. J Biol Chem. 2010;285:27694-701 pubmed publisher
    The neonatal Fc receptor, FcRn, is responsible for the long half-life of IgG molecules in vivo and is a potential therapeutic target for the treatment of autoimmune diseases...
  4. Dickinson B, Claypool S, D Angelo J, Aiken M, Venu N, Yen E, et al. Ca2+-dependent calmodulin binding to FcRn affects immunoglobulin G transport in the transcytotic pathway. Mol Biol Cell. 2008;19:414-23 pubmed
    The Fcgamma receptor FcRn transports immunoglobulin G (IgG) so as to avoid lysosomal degradation and to carry it bidirectionally across epithelial barriers to affect mucosal immunity...
  5. Mathur A, Arora T, Liu L, Crouse Zeineddini J, Mukku V. Qualification of a homogeneous cell-based neonatal Fc receptor (FcRn) binding assay and its application to studies on Fc functionality of IgG-based therapeutics. J Immunol Methods. 2013;390:81-91 pubmed publisher
    ..an important role in determining their in vivo pharmacokinetic profile by its pH-dependent binding to the neonatal Fc receptor (FcRn) which is expressed on the endothelial cells lining blood vessels...
  6. Roopenian D, Akilesh S. FcRn: the neonatal Fc receptor comes of age. Nat Rev Immunol. 2007;7:715-25 pubmed
    The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus...
  7. Story C, Mikulska J, Simister N. A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus. J Exp Med. 1994;180:2377-81 pubmed
    ..Like rat and mouse FcRn, hFcRn binds IgG preferentially at low pH, which may imply that IgG binds hFcRn in an acidic intracellular ..
  8. Li Z, Palaniyandi S, Zeng R, Tuo W, Roopenian D, Zhu X. Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection. Proc Natl Acad Sci U S A. 2011;108:4388-93 pubmed publisher
    ..We demonstrate here that the neonatal Fc receptor, FcRn, is expressed in female genital tract epithelial cells of humans and mice and binds IgG in a pH-..
  9. Andersen J, Daba M, Sandlie I. FcRn binding properties of an abnormal truncated analbuminemic albumin variant. Clin Biochem. 2010;43:367-72 pubmed publisher
    The major histocompatibility class I-related neonatal Fc receptor, FcRn, salvages both IgG and albumin from degradation and thus contributes to maintain high serum levels of these proteins...
  10. Andersen J, Daba M, Berntzen G, Michaelsen T, Sandlie I. Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding. J Biol Chem. 2010;285:4826-36 pubmed publisher
    The neonatal Fc receptor (FcRn) regulates the serum half-life of both IgG and albumin through a pH-dependent mechanism that involves salvage from intracellular degradation...
  11. Suzuki T, Ishii Watabe A, Tada M, Kobayashi T, Kanayasu Toyoda T, Kawanishi T, et al. Importance of neonatal FcR in regulating the serum half-life of therapeutic proteins containing the Fc domain of human IgG1: a comparative study of the affinity of monoclonal antibodies and Fc-fusion proteins to human neonatal FcR. J Immunol. 2010;184:1968-76 pubmed publisher
    The neonatal FcR (FcRn) binds to the Fc domain of IgG at acidic pH in the endosome and protects IgG from degradation, thereby contributing to the long serum half-life of IgG...
  12. Andersen J, Dee Qian J, Sandlie I. The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin. Eur J Immunol. 2006;36:3044-51 pubmed
    The MHC class I-related neonatal Fc receptor (FcRn) serves in the homeostatic regulation of IgG and albumin by increasing their half-lives...
  13. Ward E, Martinez C, Vaccaro C, Zhou J, Tang Q, Ober R. From sorting endosomes to exocytosis: association of Rab4 and Rab11 GTPases with the Fc receptor, FcRn, during recycling. Mol Biol Cell. 2005;16:2028-38 pubmed
    ..Here we have analyzed the association of these two Rab GTPases with the Fc receptor, FcRn, during intracellular trafficking...
  14. Ober R, Martinez C, Lai X, Zhou J, Ward E. Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Proc Natl Acad Sci U S A. 2004;101:11076-81 pubmed
    ..Through a combination of biochemical and in vivo analyses, the MHC class I-related neonatal Fc receptor (FcRn) is known to play a central role in delivering IgGs within and across cells...
  15. Ober R, Martinez C, Vaccaro C, Zhou J, Ward E. Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn. J Immunol. 2004;172:2021-9 pubmed
    The MHC class I-related receptor, FcRn, plays a central role in regulating the serum levels of IgG. FcRn is expressed in endothelial cells, suggesting that these cells may be involved in maintaining IgG levels...
  16. Chaudhury C, Mehnaz S, Robinson J, Hayton W, Pearl D, Roopenian D, et al. The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med. 2003;197:315-22 pubmed
    ..We show here that albumin binds FcRn in a pH dependent fashion, that the lifespan of albumin is shortened in FcRn-deficient mice, and that the plasma ..
  17. Shah U, Dickinson B, Blumberg R, Simister N, Lencer W, Walker W. Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Pediatr Res. 2003;53:295-301 pubmed
    The intestinal Fc receptor, FcRn, functions in the maternofetal transfer of gamma globulin (IgG) in the neonatal rodent. In humans, most of this transfer is presumed to occur in utero via the placenta...
  18. Claypool S, Dickinson B, Yoshida M, Lencer W, Blumberg R. Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin. J Biol Chem. 2002;277:28038-50 pubmed
    The major histocompatibility complex class I-related neonatal Fc receptor, FcRn, assembles as a heterodimer consisting of a heavy chain and beta(2)-microglobulin (beta(2)m), which is essential for FcRn function...
  19. Ober R, Radu C, Ghetie V, Ward E. Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol. 2001;13:1551-9 pubmed
    ..The Fc receptor, FcRn, regulates the serum half-lives of IgG in mice and most likely has a similar function in humans...
  20. Zhu X, Meng G, Dickinson B, Li X, Mizoguchi E, Miao L, et al. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J Immunol. 2001;166:3266-76 pubmed
    The neonatal Fc receptor (FcRn) for IgG, an MHC class I-related molecule, functions to transport IgG across polarized epithelial cells and protect IgG from degradation...
  21. Leach J, Sedmak D, Osborne J, Rahill B, Lairmore M, Anderson C. Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport. J Immunol. 1996;157:3317-22 pubmed
    ..to fetal circulation has not been identified, although the human homologue of the neonatal rat Fc receptor (FcRn), a heterodimer with pH-dependent IgG affinity, structurally similar to MHC Class I molecules, was recently ..
  22. Kannicht C, Kröning M, Solecka Witulska B, Kohla G, Rosenlöcher J. Comparative N-Glycosylation Analysis of the Fc Portions of a Chimeric Human Coagulation Factor VIII and Immunoglobulin G1. Bioengineering (Basel). 2017;4: pubmed publisher
    ..fusion to Fc-immunoglobulin (Ig)G that mediate protection from clearance or degradation via binding to the neonatal Fc receptor. While human-like N-glycosylation of recombinant FVIII is known to be crucial for the clotting ..
  23. Yang W, Yang G, Wang Q, Huang H, Jiang Y, Shi C, et al. Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum. Antiviral Res. 2017;138:9-21 pubmed publisher
    ..The neonatal Fc receptor (FcRn) plays an important role in transferring IgG across polarized epithelial cells...
  24. Bundhoo A, Paveglio S, Rafti E, Dhongade A, Blumberg R, Matson A. Evidence that FcRn mediates the transplacental passage of maternal IgE in the form of IgG anti-IgE/IgE immune complexes. Clin Exp Allergy. 2015;45:1085-98 pubmed publisher
    ..across the placenta in the form of IgG anti-IgE/IgE immune complexes (ICs) and to determine the role of the neonatal Fc receptor (FcRn) in mediating this process...
  25. Jacobsen B, Hill M, Reynaud L, Hey A, Barrow P. FcRn Expression on Placenta and Fetal Jejunum during Early, Mid-, and Late Gestation in Minipigs. Toxicol Pathol. 2016;44:486-91 pubmed publisher
    ..Some humanized IgGs, however, have a higher affinity for the neonatal Fc receptor (FcRn) and are more likely than endogenous antibodies to cross the placenta of animals...
  26. Dickinson B. Unraveling the immunopathogenesis of glomerular disease. Clin Immunol. 2016;169:89-97 pubmed publisher
    ..by which antibodies cause glomerular injury through their interactions with glomerular cells, complement proteins, phagocytes bearing complement and Fc? receptors, and dendritic cells expressing the neonatal receptor for IgG, FcRn.
  27. Wermeling F, Anthony R, Brombacher F, Ravetch J. Acute inflammation primes myeloid effector cells for anti-inflammatory STAT6 signaling. Proc Natl Acad Sci U S A. 2013;110:13487-91 pubmed publisher
    ..direct action of this cytokine on myeloid effector cells, depending on their expression of the IL-4 receptor alpha chain (IL-4Rα/CD124)...
  28. Stevens A, Matthews J, Andres P, Baffis V, Zheng X, Chae D, et al. Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain. Am J Physiol. 1997;272:G1201-8 pubmed
    ..We conclude that normal and T84 colonic epithelial cells express IL-15R alpha and are able to bind IL-15. IL-15 can deliver a nonproliferative functional signal in the absence of IL-2R beta-chain in T84 cells...
  29. Schilling R, Ijaz S, Davidoff M, Lee J, Locarnini S, Williams R, et al. Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions. J Virol. 2003;77:8882-92 pubmed
    ..By immunoelectron microscopy and immunoblotting, human IgG and FcRn receptor for IgG were demonstrated on cellular membranes and in cytoplasmic extracts, irrespective of the HBsAg ..
  30. Thorek D, Watson P, Lee S, Ku A, Bournazos S, Braun K, et al. Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis. Sci Transl Med. 2016;8:367ra167 pubmed
    ..Uptake is mediated by a mechanism involving the neonatal Fc receptor. Humanized 11B6, which has undergone toxicological tests in nonhuman primates, has the potential to improve ..
  31. Seijsing J, Yu S, Frejd F, Höiden Guthenberg I, Gräslund T. In vivo depletion of serum IgG by an affibody molecule binding the neonatal Fc receptor. Sci Rep. 2018;8:5141 pubmed publisher
    ..The half-life of IgG in circulation is unusually long as a consequence of its interaction with the neonatal Fc receptor (FcRn), which protects it from lysosomal degradation by cells in contact with blood...
  32. Dietrich M, Hliwa P, Adamek M, Steinhagen D, Karol H, Ciereszko A. Acclimation to cold and warm temperatures is associated with differential expression of male carp blood proteins involved in acute phase and stress responses, and lipid metabolism. Fish Shellfish Immunol. 2018;76:305-315 pubmed publisher
    ..scavenging of free hemoglobin and radicals (haptoglobin, Wap65?kDa), iv) clot-formation (fibrinogen beta and alpha chain, T-kininogen) and v) the host's immune response modulation (ApoA1 and ApoA2)...
  33. Huizing M, Cavallaro G, Moonen R, González Luis G, Mosca F, Vento M, et al. Is the C242T Polymorphism of the CYBA Gene Linked with Oxidative Stress-Associated Complications of Prematurity?. Antioxid Redox Signal. 2017;27:1432-1438 pubmed publisher
    The C242T polymorphism of CYBA (cytochrome B-245 alpha chain), the gene encoding the p22phox subunit of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, has been linked to several conditions in which oxidative stress plays a ..
  34. Pugh C. Modulation of the Hypoxic Response. Adv Exp Med Biol. 2016;903:259-71 pubmed publisher
    ..HIF transcription factors are heterodimers consisting of an oxygen-regulated alpha chain bound to the constitutive aryl hydrocarbon receptor nuclear translocator...
  35. Singer D, Zinger H, Kohn L, Mozes E. Differing MHC class I requirements for induction and propagation of experimental systemic lupus erythematosus. Eur J Immunol. 1999;29:2259-68 pubmed
    ..to disease, whereas CD1-/- and CD8-/- mice were susceptible; susceptibility also did not correlate with neonatal Fc receptor or HEPH expression...
  36. Mikulska J. Analysis of Response Elements Involved in the Regulation of the Human Neonatal Fc Receptor Gene (FCGRT). PLoS ONE. 2015;10:e0135141 pubmed publisher
    ..lines were used as model systems to study the transcriptional regulation of the human FCGRT gene encoding the alpha chain of hFcRn...
  37. Christianson G, Sun V, Akilesh S, Pesavento E, Proetzel G, Roopenian D. Monoclonal antibodies directed against human FcRn and their applications. MAbs. 2012;4:208-16 pubmed publisher
    The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers...
  38. Gouilleux Gruart V, Chapel H, Chevret S, Lucas M, Malphettes M, Fieschi C, et al. Efficiency of immunoglobulin G replacement therapy in common variable immunodeficiency: correlations with clinical phenotype and polymorphism of the neonatal Fc receptor. Clin Exp Immunol. 2013;171:186-94 pubmed publisher
    ..the variable number tandem repeat (VNTR) 3/3 polymorphism of the neonatal Fc receptor gene [IgG Fc fragment receptor transporter alpha chain (FCGRT)] promoter, and this was particularly significant in patients treated with IVIG (P <..
  39. Ng S, Nagy B, Jensen S, Hu X, Alicea C, Fox B, et al. Heterodimeric IL15 Treatment Enhances Tumor Infiltration, Persistence, and Effector Functions of Adoptively Transferred Tumor-specific T Cells in the Absence of Lymphodepletion. Clin Cancer Res. 2017;23:2817-2830 pubmed publisher
    ..showed that bioactive IL15 in vivo comprises a stable complex of the IL15 chain with the IL15 receptor alpha chain (IL15R?), termed heterodimeric IL15 (hetIL15)...
  40. Dalloneau E, Baroukh N, Mavridis K, Maillet A, Gueugnon F, Courty Y, et al. Downregulation of the neonatal Fc receptor expression in non-small cell lung cancer tissue is associated with a poor prognosis. Oncotarget. 2016;7:54415-54429 pubmed publisher
    ..Because neonatal Fc receptor (FcRn) has recently been involved in colon cancer immunosurveillance, we measured its expression in non-..
  41. Kiessling P, Lledo Garcia R, Watanabe S, Langdon G, Tran D, Bari M, et al. The FcRn inhibitor rozanolixizumab reduces human serum IgG concentration: A randomized phase 1 study. Sci Transl Med. 2017;9: pubmed publisher
    ..human autoimmune diseases; their high concentration and long half-life are dependent on recycling by the neonatal Fc receptor (FcRn). Inhibition of FcRn is an attractive new treatment concept for IgG-mediated autoimmune diseases...
  42. Grevys A, Nilsen J, Sand K, Daba M, Øynebråten I, Bern M, et al. A human endothelial cell-based recycling assay for screening of FcRn targeted molecules. Nat Commun. 2018;9:621 pubmed publisher
    Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation...
  43. Shubin Z, Tagaya Y, Poonia B. Functional polymorphisms in rhesus macaque FCGRT and β2-m. Immunogenetics. 2018;70:179-183 pubmed publisher
    ..b>Neonatal Fc receptor (FcRn), a heterodimer composed of FCGRT and β2-m chains, plays critical role in extending catabolic half-..
  44. Lee J, Hashimoto M, Im S, Araki K, Jin H, Davis C, et al. Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice. J Virol. 2017;91: pubmed publisher
    ..after immunization with Ad5 vectors revealed a defect in the expression of CD25 (interleukin-2 [IL-2] receptor alpha chain) on Ad5-elicited CD4 T cells, and administration of exogenous IL-2 following Ad5 immunization partially ..
  45. Wong H, Chow T. Physiologically Based Pharmacokinetic Modeling of Therapeutic Proteins. J Pharm Sci. 2017;106:2270-2275 pubmed publisher
    ..efflux via the lymphatic system, elimination by catabolism, protection from catabolism binding to the neonatal Fc (FcRn) receptor, and nonlinear binding to specific pharmacological targets of interest...
  46. Dossier C, Jamin A, Deschenes G. Idiopathic nephrotic syndrome: the EBV hypothesis. Pediatr Res. 2017;81:233-239 pubmed publisher
    ..We suggest that a specific anti-EBNA1 antibody internalized in the podocytes via the neonatal Fc receptor might cross-react with a major protein present in the same cell trafficking compartment...
  47. Reichert M. Proteome analysis of sheep B lymphocytes in the course of bovine leukemia virus-induced leukemia. Exp Biol Med (Maywood). 2017;242:1363-1375 pubmed publisher
    ..that trypsin inhibitor, platelet factor 4, thrombospondin 1, vasodilator-stimulated phosphoprotein, fibrinogen alpha chain, zyxin, filamin-A, and vitamin D-binding protein were downregulated, whereas cleavage and polyadenylation ..
  48. Dal Bo M, Tissino E, Benedetti D, Caldana C, Bomben R, Poeta G, et al. Functional and Clinical Significance of the Integrin Alpha Chain CD49d Expression in Chronic Lymphocytic Leukemia. Curr Cancer Drug Targets. 2016;16:659-668 pubmed
  49. Hardiansyah D, Ng C. Two-Pore Minimum Physiologically-based Pharmacokinetic Model to Describe the Disposition of Therapeutic Monoclonal IgG Antibody in Humans. Pharm Res. 2018;35:47 pubmed publisher
    ..TMAbs, supporting the hypothesis that the dynamics in the endosomal space had an important role in the compliant FcRn salvage mechanism to determine the clearance of TMAbs. The estimated FcRn concentration of FIHH subjects was 2...
  50. Liu X, Ye L, Bai Y, Mojidi H, Simister N, Zhu X. Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG. J Immunol. 2008;181:449-63 pubmed
    ..However, in this study we found that IFN-gamma down-regulated the constitutive expression of the neonatal Fc receptor (FcRn), an MHC class I-related molecule that functions to transport maternal IgG and protect IgG and ..
  51. Armitage C, O Meara C, Harvie M, Timms P, Blumberg R, Beagley K. Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens. Immunol Cell Biol. 2014;92:417-26 pubmed publisher
    ..female reproductive tract mucosal secretions, and is bi-directionally trafficked across epithelia by the neonatal Fc receptor (FcRn)...
  52. Zwolak A, Leettola C, Tam S, Goulet D, DEREBE M, Pardinas J, et al. Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding. Sci Rep. 2017;7:15521 pubmed publisher
    ..or "TLQ") in the Fc region of human IgG1 which disrupt interaction with protein A while enhancing interaction with FcRn. The mutations are shown to incrementally alter the pH at which a mAb elutes from protein A affinity resin...
  53. Weflen A, Baier N, Tang Q, Van den Hof M, Blumberg R, Lencer W, et al. Multivalent immune complexes divert FcRn to lysosomes by exclusion from recycling sorting tubules. Mol Biol Cell. 2013;24:2398-405 pubmed publisher
    The neonatal receptor for immunoglobulin G (IgG; FcRn) prevents IgG degradation by efficiently sorting IgG into recycling endosomes and away from lysosomes...
  54. Wilcox C, Holder B, Jones C. Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy. Front Immunol. 2017;8:1294 pubmed publisher
    ..Transcytosis of IgG occurs via binding with the neonatal Fc receptor (FcRn) in the placental synctiotrophoblast...
  55. Shen Y, Li H, Zhao L, Li G, Chen B, Guo Q, et al. Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates. PLoS ONE. 2017;12:e0183326 pubmed publisher
    ..The Fc-modified mAbs exhibited increased binding to FcRn, resulting in prolonged serum half-life and enhanced efficacy in vivo...
  56. Wang W, Vlasak J, Li Y, Pristatsky P, Fang Y, Pittman T, et al. Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies. Mol Immunol. 2011;48:860-6 pubmed publisher
    ..functions (via interactions with Fc? receptors) and extended serum half-life (via interaction with the neonatal Fc receptor, FcRn)...
  57. Fatah H, Benfaed N, Chana R, Chunara M, Barratt J, Baines R, et al. Reduced proximal tubular expression of protein endocytic receptors in proteinuria is associated with urinary receptor shedding. Nephrol Dial Transplant. 2018;33:934-943 pubmed publisher
    ..including albumin, are reabsorbed in the proximal tubule (PT) mediated by megalin, cubilin and the neonatal Fc receptor (FcRn)...
  58. Baker J, Lewis E, Byland L, Bonakdar M, Randis T, Ratner A. Mucosal vaccination promotes clearance of Streptococcus agalactiae vaginal colonization. Vaccine. 2017;35:1273-1280 pubmed publisher
    ..Our results support a role for humoral immunity in GBS eradication from the female genital tract and suggest that mucosal vaccination may prime colonization clearance. ..
  59. Xi Y, Troy N, Anderson D, Pena O, Lynch J, Phipps S, et al. Critical Role of Plasmacytoid Dendritic Cells in Regulating Gene Expression and Innate Immune Responses to Human Rhinovirus-16. Front Immunol. 2017;8:1351 pubmed publisher
    ..the transcription factor IRF7, both IL-27 chains (IL-27p28 and EBI3), the alpha chain of the IL-15 receptor (IL-15RA) and the IFN-related gene IFI27...
  60. Freiberger T, Grodecka L, Ravcukova B, Kurecová B, Postránecká V, Vlcek J, et al. Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency. Clin Immunol. 2010;136:419-25 pubmed publisher
    The neonatal Fc receptor (FcRn) acts as a key regulator of IgG homeostasis and is an important sensor of luminal infection...
  61. Sugden S, Ghazawi F, MacPherson P. HIV-1 tat protein recruits CIS to the cytoplasmic tail of CD127 to induce receptor ubiquitination and proteasomal degradation. Virology. 2016;498:192-200 pubmed publisher
    ..Tat therefore acts as an adapter to induce cellular responses under conditions where they may not otherwise occur. Thusly, Tat reduces IL-7 signaling and impairs CD8 T cell survival and function. ..
  62. Cianga P, Cianga C, Plamadeala P, Branisteanu D, Carasevici E. The neonatal Fc receptor (FcRn) expression in the human skin. Virchows Arch. 2007;451:859-60 pubmed
  63. Datta Mannan A, Lu J, Witcher D, Leung D, Tang Y, Wroblewski V. The interplay of non-specific binding, target-mediated clearance and FcRn interactions on the pharmacokinetics of humanized antibodies. MAbs. 2015;7:1084-93 pubmed publisher
    ..Physiological factors including interactions with the neonatal Fc receptor (FcRn) and specific antigen binding properties of mAbs, along with biophysical properties of the mAbs ..
  64. Christianson G, Brooks W, Vekasi S, Manolfi E, Niles J, Roopenian S, et al. Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism. J Immunol. 1997;159:4781-92 pubmed
    ..the transfer of maternal IgG into the prenatal/neonatal mouse made possible by the beta 2m-dependent Fc receptor (FcRn)...
  65. Lambrecht B. FcRn is mother's milk to allergen tolerance. J Exp Med. 2017;: pubmed publisher
    ..how breastfeeding can prevent the onset of food allergies in offspring by instructing T reg formation via neonatal Fc receptor (FcRn)-mediated transfer and uptake of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic ..
  66. Neuber T, Frese K, Jaehrling J, Jäger S, Daubert D, Felderer K, et al. Characterization and screening of IgG binding to the neonatal Fc receptor. MAbs. 2014;6:928-42 pubmed publisher
    The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from degradation and increases the serum half-life of IgG, thereby contributing to a higher concentration of IgG in the serum...
  67. Kühn A, Ackermann M, Mussolino C, Cathomen T, Lachmann N, Moritz T. TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis. Sci Rep. 2017;7:15195 pubmed publisher
  68. Jiang C, Huang T, Wang Y, Huang G, Wan X, Gu J. Immunoglobulin G expression in lung cancer and its effects on metastasis. PLoS ONE. 2014;9:e97359 pubmed publisher
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    The neonatal Fc receptor (FcRn) is important for the metabolic fate of IgG antibodies in vivo...
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    ..HSA has a plasma half-life of around 21 days because of its interaction with the neonatal Fc receptor (FcRn) expressed in endothelial cells of blood vessels, which rescues circulating HSA from lysosomal ..
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    ..3) rapid clearance from systemic circulation compared with molecules with wild type Fc region for normal FcRn binding, which may reduce the risk of systemic complications; and 4) low risk of potential effector function...
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    ..We also identify that the neonatal Fc receptor (FcRn) is upregulated in the cornea following infection or injury concomitant with increased Ab perfusion...
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    ..Exome sequencing revealed nonsynonymous mutations in five genes in the runs of homozygosity: CHEK2, FCGRT, INPP5J, MYO18B, and SFI1...
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    ..5 × 10(-8)) for serum albumin (HPN-SCN1B, GCKR-FNDC4, SERPINF2-WDR81, TNFRSF11A-ZCCHC2, FRMD5-WDR76, and RPS11-FCGRT, in up to 53,190 European-ancestry and 9,380 Japanese individuals) and three loci for total protein (TNFRS13B, ..
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    ..The IgG transport receptor neonatal Fc receptor (FcRn) is a candidate mediator of these processes...
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    Studies on mouse models have indicated that the neonatal Fc receptor (FcRn) plays important roles in a variety of autoimmune diseases...
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    ..and molecular dynamics simulations have been carried out to model the detailed structures of the human neonatal Fc receptor (FcRn) binding with the wild-type Fc of human immunoglobulin G1 (IgG1) and its various mutants...
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    We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands...
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    ..We assessed safety, clinical response, and pretreatment anti-platelet-derived growth factor receptor alpha chain (anti-PDGFRA) antibody levels...
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    ..Further antibodies against IL-5 receptor (Benralizumab) or against the IL-4 receptor alpha chain (Dupilumab) are in advanced clinical development.
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    ..biomarker candidates, and they were identified as fragments of vitronectin precursor, isoform 1 of fibrinogen alpha chain precursor, prothrombin precursor and inter-alpha-trypsin inhibitor heavy chain H4...
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    ..The described time-resolved immunofluorometric assay for CA VI might be useful to identify or exclude diseases of the salivary glands in the differential diagnosis of patients whose serum amylase concentrations are increased. ..