FCGR2C

Summary

Gene Symbol: FCGR2C
Description: Fc fragment of IgG receptor IIc (gene/pseudogene)
Alias: CD32, CD32C, CDW32, FCG2, FCRIIC, IGFR2, low affinity immunoglobulin gamma Fc region receptor II-c, Fc fragment of IgG, low affinity IIc, receptor for (CD32), Fc gamma receptor IIC, IgG Fc receptor II-c, fc-gamma-RIIc, immunoglobulin G Fc receptor II-c
Species: human
Products:     FCGR2C

Top Publications

  1. Warmerdam P, Nabben N, van de Graaf S, van de Winkel J, Capel P. The human low affinity immunoglobulin G Fc receptor IIC gene is a result of an unequal crossover event. J Biol Chem. 1993;268:7346-9 pubmed
    ..The proposed site of recombination was located approximately 300 nucleotides downstream from the sixth (C1) exon. These data provide a unique model for the evolutionary generation of a receptor family with multiple biological functions. ..
  2. Breunis W, van Mirre E, Bruin M, Geissler J, de Boer M, Peters M, et al. Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura. Blood. 2008;111:1029-38 pubmed
    ..As indicated by the prevalence of an open reading frame of FCGR2C, Fcgamma receptor (FcgammaR) type IIc is expressed in 18% of healthy individuals and is strongly associated with ..
  3. Breunis W, van Mirre E, Geissler J, Laddach N, Wolbink G, van der Schoot E, et al. Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B. Hum Mutat. 2009;30:E640-50 pubmed publisher
    ..A novel CNV for FCGR3A was observed. Similar to FCGR3B and FCGR2C, a gene-dosage effect of FCGR3A was found, that seemed to correlate nicely with the FcgammaRIIIa expression on NK ..
  4. Chen R, Zhang K, Chen H, Zhao X, Wang J, Li L, et al. Telomerase Deficiency Causes Alveolar Stem Cell Senescence-associated Low-grade Inflammation in Lungs. J Biol Chem. 2015;290:30813-29 pubmed publisher
    ..of a mononuclear cell population positive for the leukocyte common antigen CD45, low-affinity Fc receptor CD16/CD32, and pattern recognition receptor CD11b in the lungs...
  5. Fomin M, Zhou Y, Beyer A, Publicover J, Baron J, Muench M. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS ONE. 2013;8:e77255 pubmed publisher
    ..LSECs, thereby providing the means for their purification and culture based on their expression of CD14 and CD32 as well as a lack of CD45 expression...
  6. Ng H, Zhu X, Harmon E, Lennartz M, Nagarajan S. Reduced Atherosclerosis in apoE-inhibitory FcγRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages. Arterioscler Thromb Vasc Biol. 2015;35:1101-12 pubmed publisher
    ..As 129/sv genome-derived lupus-associated genes have been implicated in lupus phenotype in FcγRIIb129/B6 (-/-) mice, our findings suggest possible epistatic mechanism contributing to the decreased lesions. ..
  7. Walsh A, Whitaker J, Huang C, Cherkas Y, Lamberth S, Brodmerkel C, et al. Integrative genomic deconvolution of rheumatoid arthritis GWAS loci into gene and cell type associations. Genome Biol. 2016;17:79 pubmed publisher
    ..While not experimentally validated here, the reported eQTLs and cell type-specific RA risk associations can prioritize future experiments with the goal of elucidating the regulatory mechanisms behind genetic risk associations. ..
  8. Kikuchi Ueda T, Kamoshida G, Ubagai T, Nakano R, Nakano A, Akuta T, et al. The TNF-? of mast cells induces pro-inflammatory responses during infection with Acinetobacter baumannii. Immunobiology. 2017;222:1025-1034 pubmed publisher
    ..baumannii was tightly attached to the surface of LAD2 cells and suggested that A. baumannii may bind to Fc?RII (CD32) on LAD2 cells. TNF-? in the culture supernatant from A...
  9. Fang W, Fa Z, Liao W. Epidemiology of Cryptococcus and cryptococcosis in China. Fungal Genet Biol. 2015;78:7-15 pubmed publisher
    ..In addition, intrathecal administration of amphotericin B has been proved to be an effective adjunctive treatment for cryptococcosis in China. ..

More Information

Publications134 found, 100 shown here

  1. Bocchini N, Giantin M, Crivellente F, Ferraresso S, Faustinelli I, Dacasto M, et al. Molecular biomarkers of phospholipidosis in rat blood and heart after amiodarone treatment. J Appl Toxicol. 2015;35:90-103 pubmed
    ..Collectively, these data underscore the importance of transcriptional profiling in drug discovery and development, and suggest blood as a surrogate tissue for possible phospholipid accumulation in cardiomyocytes. ..
  2. Hénaut L, Grissi M, Brazier F, Assem M, Poirot Leclercq S, Lenglet G, et al. Cellular and molecular mechanisms associated with ischemic stroke severity in female mice with chronic kidney disease. Sci Rep. 2019;9:6432 pubmed publisher
    ..Apoptosis, neuronal loss, glial cells recruitment and microglia/macrophages M1 signature genes CD32, CD86, IL-1β, IL-6, MCP1 and iNOS were significantly increased within ischemic lesions of CKD mice...
  3. Mangin G, Poittevin M, Charriaut Marlangue C, Giannesini C, Merkoulova Rainon T, Kubis N. Glatiramer acetate reduces infarct volume in diabetic mice with cerebral ischemia and prevents long-term memory loss. Brain Behav Immun. 2019;: pubmed publisher
    ..Moreover, proinflammatory mediators significantly decreased between D3 (COX2) and D7 (CD32, TNFα, IL-1β), and neurogenesis was significantly increased at D7...
  4. Aoki Y, Watanabe T, Saito Y, Kuroki Y, Hijikata A, Takagi M, et al. Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia. Blood. 2015;125:967-80 pubmed publisher
    ..Global gene expression profiling revealed that CD9, CD32, and CD24 were over-represented in MLL-AF4, MLL-AF9, and MLL-ENL LICs compared with normal HSCs...
  5. Stegner D, Popp M, Lorenz V, Wax J, Gessner J, Nieswandt B. Fc?RIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice. Blood. 2016;128:862-5 pubmed publisher
    ..These results reveal a novel and unexpected function of hepatic Fc?RIIB in the targeted downregulation of GPVI in vivo. ..
  6. Tsertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N. Aberrant expression of Fcγ-receptors and Toll like receptor CD180 on monocytes from patients with chronic lymphocytic leukaemia. Georgian Med News. 2015;:35-8 pubmed
    ..address of monocytes functional status through assessment of the patterns of expression of Fcγ receptors CD64, CD32, CD16 and CD180 receptor on monocytes from CLL patients and healthy individuals using specific mAbs and flow ..
  7. Raque V, Carlos S, Eduardo R, Rafael B, Ángeles R, Adriana R, et al. Modification of immunological features in human platelets during sepsis. Immunol Invest. 2017;:1-16 pubmed publisher
    ..The results show that platelets of these individuals have high levels of surfaces expression of TLR4, CD62P, CD32 and thrombin receptor 1 (PAR-1), these platelets have also greater capability to join Escherichia coli, and show a ..
  8. Suzuki A, Horie T, Numabe Y. Investigation of molecular biomarker candidates for diagnosis and prognosis of chronic periodontitis by bioinformatics analysis of pooled microarray gene expression datasets in Gene Expression Omnibus (GEO). BMC Oral Health. 2019;19:52 pubmed publisher
    ..To our knowledge, this is the first report to reveal associations of CD53, CD79A, MS4A1, PECAM1, and TAGLN with CP. ..
  9. Gelabert P, Olalde I, de Dios T, Civit S, Lalueza Fox C. Malaria was a weak selective force in ancient Europeans. Sci Rep. 2017;7:1377 pubmed publisher
    ..These results suggest that the selective force represented by malaria was relatively weak in Europe, a fact that could be associated to a recent historical introduction of the severe malaria pathogen. ..
  10. Chauhan P, Hu S, Sheng W, Prasad S, Lokensgard J. Modulation of Microglial Cell Fcγ Receptor Expression Following Viral Brain Infection. Sci Rep. 2017;7:41889 pubmed publisher
    ..In contrast, expression of the inhibitory FcγRIIB receptor promotes M2-polarization in order to shut-down deleterious immune responses and limit bystander brain damage. ..
  11. Zi C, Zeng D, Zhou J, Dai J, Jiang L, Xue F, et al. Selected microRNA-192 mutant indicates association with several function genes in bovine cells. Genes Genomics. 2018;40:361-371 pubmed publisher
    ..These findings provided useful guidance for investigating the role played by bta-miR-192 in cellular functionality in bovine cells. ..
  12. Pilling D, Fan T, Huang D, Kaul B, Gomer R. Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts. PLoS ONE. 2009;4:e7475 pubmed publisher
    ..In addition, IL-4, IL-12, IL-13, IFN-gamma, and SAP differentially regulate the expression of CD32, CD163, CD172a, and CD206 on both macrophages and fibrocytes...
  13. Negishi Koga T, Gober H, Sumiya E, Komatsu N, Okamoto K, Sawa S, et al. Immune complexes regulate bone metabolism through FcRγ signalling. Nat Commun. 2015;6:6637 pubmed publisher
    ..These results demonstrate a link between the adaptive immunity and bone, suggesting a regulatory role for ICs in bone resorption in general, and not only in inflammatory diseases. ..
  14. Golay J, Valgardsdottir R, Musaraj G, Giupponi D, Spinelli O, Introna M. Human neutrophils express low levels of FcγRIIIA, which plays a role in PMN activation. Blood. 2019;: pubmed publisher
    ..Use of blocking anti-CD16 and -CD32 antibodies showed that FcγRIIIA is also a major mediator of phagocytosis of CD20 opsonized beads by both FcγRIIIB ..
  15. Zhao Q, Ahmed M, Guo H, Cheung I, Cheung N. Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody hu3F8. J Biol Chem. 2015;290:13017-27 pubmed publisher
    ..translated into a ∼12-fold improvement in NK92MI-transfected CD16-mediated ADCC, a 6-fold improvement in CD32-mediated ADCC, and a 2...
  16. Li X, Guo X, Liu H, Gao G, Xu G, Fei X, et al. Skin inflammation induced by lupus serum was inhibited in IL-1R deficient mice. Clin Immunol. 2017;180:63-68 pubmed publisher
    ..IL-1R deficiency did not affect the expression of Fc?RI (CD64), Fc?RII (CD32) and MHC class II (CD74) induced by lupus serum...
  17. Nguyen T, Havari E, McLaren R, Zhang M, Jiang Y, Madden S, et al. Alemtuzumab induction of intracellular signaling and apoptosis in malignant B lymphocytes. Leuk Lymphoma. 2012;53:699-709 pubmed publisher
    ..Apoptosis was prevented by blocking of FcγRIIb receptors with anti-CD32 antibody...
  18. Arthur S, Jiang A, Grande B, Alcaide M, Cojocaru R, Rushton C, et al. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018;9:4001 pubmed publisher
    ..These results expand the list of subgroup driver mutations that may facilitate implementation of improved diagnostic assays and could offer new avenues for the development of targeted therapeutics. ..
  19. McArdel S, Brown D, Sobel R, Sharpe A. Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells. J Immunol. 2016;197:3038-3048 pubmed
    ..effector CD4+ T cells in Fc?r1?-/- mice or in wild-type mice receiving anti-CD16/CD32 mAb...
  20. Kavanagh E, Burguillos M, Carrillo Jimenez A, Oliva Martin M, Santiago M, Rodhe J, et al. Deletion of caspase-8 in mouse myeloid cells blocks microglia pro-inflammatory activation and confers protection in MPTP neurodegeneration model. Aging (Albany NY). 2015;7:673-89 pubmed
    ..In contrast, CD16/CD32 expression, a microglial pro-inflammatory marker, was found to be negatively affected upon CASP8 deletion...
  21. Sun Y, Zhuang Z, Wang X, Huang H, Fu Q, Yan Q. Dual RNA-seq reveals the effect of the flgM gene of Pseudomonas plecoglossicida on the immune response of Epinephelus coioides. Fish Shellfish Immunol. 2019;87:515-523 pubmed publisher
    ..plecoglossicida. Among them, the expression of mhc2, zap70, rhoh, tlr2, ca79a, hcst and cd32 in E. coioides spleen was predicted to be negatively related to flgM in P...
  22. Pan J, Jin J, Ge H, Yin K, Chen X, Han L, et al. Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner. J Neuroinflammation. 2015;12:51 pubmed publisher
    ..Moreover, treatment of MA decreased M1 markers (CD16, CD32, and CD86) and increased M2 markers (CD206, YM-1) while promoting the activation of nuclear receptor PPARγ...
  23. Hori A, Fujimura T, Kawamoto S. Anti-inflammatory intravenous immunoglobulin (IVIg) suppresses homeostatic proliferation of B cells. Cytotechnology. 2018;70:921-927 pubmed publisher
    ..unaffected by treatment with a neutralizing antibody against low-affinity Fc receptors for IgG (CD16/Fc?RIII and CD32/Fc?RII), known cell surface ligands for IVIg...
  24. Lee S, Kim J, Choi S. Endogenous amyloid-β mediates memory forgetting in the normal brain. Biochem Biophys Res Commun. 2018;506:492-497 pubmed publisher
    ..Taken together, these findings suggest that endogenous Aβ is involved in memory forgetting in the normal brain. ..
  25. Zuccherato L, Schneider S, Tarazona Santos E, Hardwick R, Berg D, Bogle H, et al. Population genetics of immune-related multilocus copy number variation in Native Americans. J R Soc Interface. 2017;14: pubmed publisher
    ..loci associated with complex diseases (beta-defensins, CCL3L1/CCL4L1, FCGR3A, FCGR3B and FCGR2C) in 12 traditional Native American populations and found that the population structure parameters inferred for ..
  26. Hollox E, Hoh B. Human gene copy number variation and infectious disease. Hum Genet. 2014;133:1217-33 pubmed publisher
    ..variation generated by a combination of CNV and sequence variation, as illustrated by the Fc gamma receptor genes FCGR3A, FCGR3B and FCGR2C. We also highlight some understudied areas that might prove fruitful areas for further research.
  27. Gwon Y, Kam T, Kim S, Song S, Park H, Lim B, et al. TOM1 Regulates Neuronal Accumulation of Amyloid-β Oligomers by FcγRIIb2 Variant in Alzheimer's Disease. J Neurosci. 2018;38:9001-9018 pubmed publisher
    ..Further, Aβ internalization is attenuated by TOM1, a novel FcγRIIb2-binding protein. Together, we provide a molecular mechanism responsible for neuronal uptake of pathogenic Aβ found in AD. ..
  28. Tasnim F, Xing J, Huang X, Mo S, Wei X, Tan M. Generation of mature kupffer cells from human induced pluripotent stem cells. Biomaterials. 2019;192:377-391 pubmed publisher
    ..iKCs expressed macrophage markers (CD11/CD14/CD68/CD163/CD32) at 0.3-5 folds of primary adult human KCs (pKCs) and KC-specific CLEC-4F, ID1 and ID3...
  29. Abdel Mohsen M, Kuri Cervantes L, Grau Expósito J, Spivak A, Nell R, Tomescu C, et al. CD32 is expressed on cells with transcriptionally active HIV but does not enrich for HIV DNA in resting T cells. Sci Transl Med. 2018;10: pubmed publisher
    ..We aimed to determine whether CD32 expression marks HIV latently or transcriptionally active infected CD4+ T cells...
  30. Tsertsvadze T, Mitskevich N, Ghirdaladze D, Porakishvili N. Correlation of the expression of CD32 and CD180 receptors on CLL cells and MEC1 cell line. Georgian Med News. 2015;:56-9 pubmed
    ..Additional accessory signals could be generated through FcγRII (CD32), since both are expressed on CLL cells as well as on control B cells...
  31. Noto A, Procopio F, Banga R, Suffiotti M, Corpataux J, Cavassini M, et al. CD32+ and PD-1+ Lymph Node CD4 T Cells Support Persistent HIV-1 Transcription in Treated Aviremic Individuals. J Virol. 2018;92: pubmed publisher
    A recent study conducted in blood has proposed CD32 as the marker identifying the "elusive" HIV reservoir...
  32. Karpus O, Kiener H, Niederreiter B, Yilmaz Elis A, van der Kaa J, Ramaglia V, et al. CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis. Arthritis Res Ther. 2015;17:6 pubmed publisher
    ..studied in the K/BxN serum transfer model of arthritis using mice that in addition to CD55 also lack FcγRIIB (CD32), increasing susceptibility for immune complex-mediated pathology...
  33. Xu J, Zhao L, Zhang Y, Guo Q, Chen H. CD16 and CD32 Gene Polymorphisms May Contribute to Risk of Idiopathic Thrombocytopenic Purpura. Med Sci Monit. 2016;22:2086-96 pubmed
    BACKGROUND Epidemiological studies have evaluated the associations of CD16 158F>V and CD32 131H>R gene polymorphisms with the risk of idiopathic thrombocytopenic purpura (ITP)...
  34. Auray G, Keller I, Python S, Gerber M, Bruggmann R, Ruggli N, et al. Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences. J Immunol. 2016;197:4791-4806 pubmed
    ..Our data demonstrate that extrapolation of data on DC biology from one species to another has to be done with care, and it shows how functional details have evolved differentially in different species. ..
  35. Badia R, Ballana E, Castellví M, Garcia Vidal E, Pujantell M, Clotet B, et al. CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir. Nat Commun. 2018;9:2739 pubmed publisher
    b>CD32 has been shown to be preferentially expressed in latently HIV-1-infected cells in an in vitro model of quiescent CD4 T cells...
  36. de Miranda Torrinhas R, Santana R, Garcia T, Cury Boaventura M, Sales M, Curi R, et al. Parenteral fish oil as a pharmacological agent to modulate post-operative immune response: a randomized, double-blind, and controlled clinical trial in patients with gastrointestinal cancer. Clin Nutr. 2013;32:503-10 pubmed publisher
    ..on day 6, lower decrease in leukocyte oxidative burst, maintenance of monocyte percentage expressing HLA-DR and CD32, and increase of CD32 neutrophil expression compared to MCT/LCT patients...
  37. Hoonhorst S, Timens W, Koenderman L, Lo Tam Loi A, Lammers J, Boezen H, et al. Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD. Respir Res. 2014;15:121 pubmed publisher
    ..Young susceptible individuals showed significantly higher increases in the expression of FcγRII (CD32) in its active forms (A17 and A27) on neutrophils after smoking (p = 0.016 and 0...
  38. Baëhl S, Garneau H, Le Page A, Lorrain D, Viens I, Svotelis A, et al. Altered neutrophil functions in elderly patients during a 6-month follow-up period after a hip fracture. Exp Gerontol. 2015;65:58-68 pubmed publisher
    ..Whereas FcγRII (CD32) expression remained unchanged, FcγRIII (CD16) increased from low values before surgery to levels of controls ..
  39. Chekalina N, Kazakov Y, Mamontova T, Vesnina L, Kaidashev I. Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor ? in patients with coronary artery disease. Wiad Lek. 2016;69:475-479 pubmed
    ..The cytofluorometric technique was applied to define the level of circulating endothelial microparticles (EMP) CD32+CD40+ in peripheral blood in order to identify ED...
  40. Aredo B, Zhang K, Chen X, Wang C, Li T, Ufret Vincenty R. Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1 rd8/rd8) versus C57BL6/J (Crb1 wt/wt) mice. J Neuroinflammation. 2015;12:6 pubmed publisher
    ..RPE) flat mounts was done for 1) Ionized calcium binding adaptor (Iba)-1, 2) FcγIII/II Receptor (CD16/CD32, abbreviated as CD16), and 3) Macrophage mannose receptor (MMR)...
  41. Oliveira M, Saraiva D, Cavadas B, Fernandes V, Pedro N, Casademont I, et al. Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease. Infect Genet Evol. 2018;62:60-72 pubmed publisher
    ..Seven markers (in PLCE1, CD32, CD209, OAS1 and OAS3 genes) have high-frequency and the other three (in MICB and TNFA genes) have intermediate ..
  42. Fromm J, Thomas A, Wood B. Characterization and Purification of Neoplastic Cells of Nodular Lymphocyte Predominant Hodgkin Lymphoma from Lymph Nodes by Flow Cytometry and Flow Cytometric Cell Sorting. Am J Pathol. 2017;187:304-317 pubmed publisher
    ..we immunophenotyped the NLPHL cell line (DEV) confirming a germinal center immunophenotype, lack of expression of CD32 and CD58, and expression of CD54...
  43. Huang Y, Heiser R, Detanico T, Getahun A, Kirchenbaum G, Casper T, et al. γδ T cells affect IL-4 production and B-cell tolerance. Proc Natl Acad Sci U S A. 2015;112:E39-48 pubmed publisher
    ..Its B cells expressed IL-4-regulated inhibitory receptors (CD5, CD22, and CD32) at diminished levels, whereas IL-4-inducible IL-4 receptor α and MHCII were increased...
  44. Montes A, Perez Pampin E, Joven B, Carreira P, Fernández Nebro A, Del Carmen Ordóñez M, et al. FCGR polymorphisms in the treatment of rheumatoid arthritis with Fc-containing TNF inhibitors. Pharmacogenomics. 2015;16:333-45 pubmed publisher
    ..In addition, meta-analysis of FCGR3A F158V was also negative against the results provided by previous studies. Original submitted 17 September 2014; Revision submitted 9 December 2014. ..
  45. Chekalina N, Kazakov Y, Mamontova T, Vesnina L, Kaidashev I. Resveratrol more effectively than quercetin reduces endothelium degeneration and level of necrosis factor ? in patients with coronary artery disease. Wiad Lek. 2016;69:475-479 pubmed
    ..The cytofluorometric technique was applied to define the level of circulating endothelial microparticles (EMP) CD32+CD40+ in peripheral blood in order to identify ED...
  46. Willcocks L, Carr E, Niederer H, Rayner T, Williams T, Yang W, et al. A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2010;107:7881-5 pubmed publisher
    ..56; P = 7.1 x 10(-5)). This protective effect against malaria may contribute to the higher frequency of this SNP and hence, SLE in Africans and Southeast Asians. ..
  47. Weiner J, Duran Struuck R, Zitsman J, Buhler L, Sondermeijer H, McMurchy A, et al. Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells. Transplant Direct. 2015;1:1-7 pubmed
    ..and expanded for 26 days in culture with IL-2, anti-CD3 antibody, artificial APCs transfected with human CD58, CD32, and CD80, and rapamycin with weekly restimulations...
  48. Zizzo G, Cohen P. Antibody Cross-Linking of CD14 Activates MerTK and Promotes Human Macrophage Clearance of Apoptotic Neutrophils: the Dual Role of CD14 at the Crossroads Between M1 and M2c Polarization. Inflammation. 2018;41:2206-2221 pubmed publisher
    ..The effects of antibody-mediated cross-linking of M2c receptors (i.e., CD14, CD16, CD32, CD163, CD204) on MerTK phosphorylation and phagocytosis of ANs were tested...
  49. Franke L, el Bannoudi H, Jansen D, Kok K, Trynka G, Diogo D, et al. Association analysis of copy numbers of FC-gamma receptor genes for rheumatoid arthritis and other immune-mediated phenotypes. Eur J Hum Genet. 2016;24:263-70 pubmed publisher
    ..The first region encodes FCGR2A, FCGR3A and part of FCGR2C gene, the second encodes another part of FCGR2C, FCGR3B and FCGR2B...
  50. Ajeganova S, Tesfa D, Hagglund H, Fadeel B, Vedin I, Zignego A, et al. Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab. Arthritis Res Ther. 2017;19:44 pubmed publisher
    ..The role of the BAFF -871C/T promoter polymorphism in LON occurrence is unclear. ..
  51. Grau Expósito J, Serra Peinado C, Miguel L, Navarro J, Curran A, Burgos J, et al. A Novel Single-Cell FISH-Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV-1 Transcription in HIV-Infected Patients. MBio. 2017;8: pubmed publisher
    ..found that after ex vivo infection of unstimulated PBMCs, HIV-infected T cells upregulated the expression of CD32. In addition, this new methodology detected increased numbers of primary cells expressing viral transcripts and ..
  52. Magnusson S, Wennerberg E, Matt P, Lindqvist U, Kleinau S. Dysregulated Fc receptor function in active rheumatoid arthritis. Immunol Lett. 2014;162:200-6 pubmed publisher
    ..Prior the functional studies the monocytes were characterized of their FcγRI (CD64), II (CD32), IIb (CD32b) and III (CD16) expression as well as their cell surface bound IgG...
  53. Moreno Fierros L, Verdín Terán S, García Hernández A. Intraperitoneal Immunization with Cry1Ac Protoxin from Bacillus thuringiensis Provokes Upregulation of Fc-Gamma-II/and Fc-Gamma-III Receptors Associated with IgG in the Intestinal Epithelium of Mice. Scand J Immunol. 2015;82:35-47 pubmed publisher
    ..So, first we determined whether CD16/32 [an epitope shared by Fcγ-RII (CD32) and Fcγ-RIII (CD16)] was expressed in the intestinal epithelia of mice...
  54. Espéli M, Clatworthy M, Bökers S, Lawlor K, Cutler A, Köntgen F, et al. Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity. J Exp Med. 2012;209:2307-19 pubmed publisher
  55. Kapelski S, Klockenbring T, Fischer R, Barth S, Fendel R. Assessment of the neutrophilic antibody-dependent respiratory burst (ADRB) response to Plasmodium falciparum. J Leukoc Biol. 2014;96:1131-42 pubmed publisher
    ..In the sADRB assay, ROS were produced externally, and by specific blocking of CD32(a)/FcγRII(a), the immediate neutrophilic response was abolished, whereas the removal of CD16(b)/FcγRIII(b) ..
  56. Vollack N, Friese J, Bergmann S, Cragg M, Tiede A, Werwitzke S. Anti-Fc?RIIB (CD32) Antibodies Differentially Modulate Murine FVIII-Specific Recall Response in vitro. Scand J Immunol. 2017;86:91-99 pubmed publisher
    ..Data from a haemophilia A mouse model demonstrate that genetic deletion or blockade of the inhibitory Fc?R (CD32) suppresses the formation of antibody-secreting cells (ASCs) in vitro...
  57. Trowald Wigh G, Johannisson A, Hakansson L. Canine neutrophil adhesion proteins and Fc-receptors in healthy dogs and dogs with adhesion protein deficiency, as studied by flow cytometry. Vet Immunol Immunopathol. 1993;38:297-310 pubmed
    ..against neutrophil adhesion protein receptors CD35, CD18, CD11b, CD11c and the Fc-receptors CD64 (Fc gamma RI), CD32 (FC gamma RII) and CD16 (Fc gamma RIII) were evaluated regarding their ability to bind to the canine homologues...
  58. Suenaga J, Hu X, Pu H, Shi Y, Hassan S, Xu M, et al. White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke. Exp Neurol. 2015;272:109-19 pubmed publisher
    ..We further examined the expression of M1 (CD16/CD32) and M2 (CD206) markers in Iba-1(+) microglia by double immunofluorescent staining...
  59. Moraru M, Black L, Muntasell A, Portero F, López Botet M, Reyburn H, et al. NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation. J Immunol. 2015;195:1676-84 pubmed publisher
    ..allotypes with different IgG affinity, variations conditioning NK cell expression of CD32B or CD32C, and IgG1 H chain (IGHG1) and kappa-chain (IGKC) polymorphisms determining allotypes designated G1m and Km...
  60. Nancy Hilda J, Das S. Neutrophil CD64, TLR2 and TLR4 expression increases but phagocytic potential decreases during tuberculosis. Tuberculosis (Edinb). 2018;111:135-142 pubmed publisher
    ..the phagocytosis potential and expression of toll like receptors (TLR1, TLR2 and TLR4) and Fcγ receptors (CD64 and CD32) by human neutrophils following infection with Mycobacterium tuberculosis strains...
  61. Cho H, Kim S, Sohn D, Lee M, Park M, Sohn H, et al. Triple costimulation via CD80, 4-1BB, and CD83 ligand elicits the long-term growth of Vγ9Vδ2 T cells in low levels of IL-2. J Leukoc Biol. 2016;99:521-9 pubmed publisher
    ..and expansion ex vivo, Vγ9Vδ2 T cells were grown with artificial APCs that express CD83, 4-1BB ligand, and/or CD32, which allowed a loading of αCD3 and αCD28 antibodies...
  62. Ma X, Xu F, Gao L, Wang Y, Pan Z. Effect of age on the immune system and pathology of mice with chronic graft-versus-host disease lupus nephritis. Genet Mol Res. 2015;14:10999-1005 pubmed publisher
    ..Expression levels of CD16/32+CD19(T1), CD16/CD32+CD3(T2), and CD64+CD3 or CD19(T3) were defined in the thymus, in bone marrow they were defined as CD16/32+CD19(B1), ..
  63. Lai W, Tang Y, Huang X, Ming Kuen Tang P, Xu A, Szalai A, et al. C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E. Kidney Int. 2016;90:610-26 pubmed publisher
    ..and ERK/MAPK cross talk mechanisms, Smad3 bound directly to p27, and blockade of Smad3 or the Fc receptor CD32 prevented C-reactive protein-induced p27-dependent G1 cell cycle arrest...
  64. Marvin S, Russier M, Huerta C, Russell C, Schultz Cherry S. Influenza Virus Overcomes Cellular Blocks To Productively Replicate, Impacting Macrophage Function. J Virol. 2017;91: pubmed publisher
    ..productive viral replication decreased phagocytosis of IgG-opsonized bioparticles and Fc receptor CD16 and CD32 surface levels, a function, to our knowledge, never before reported for an RNA virus...
  65. Xie Y, Guo H, Wang L, Xu L, Zhang X, Yu L, et al. Human albumin attenuates excessive innate immunity via inhibition of microglial Mincle/Syk signaling in subarachnoid hemorrhage. Brain Behav Immun. 2017;60:346-360 pubmed publisher
    ..Markers of microglia M1 polarization (iNOS, IL-1?, CD16, and CD32) were remarkably suppressed...
  66. Esnault S, Johansson M, Kelly E, Koenderman L, Mosher D, Jarjour N. IL-3 up-regulates and activates human eosinophil CD32 and αMβ2 integrin causing degranulation. Clin Exp Allergy. 2017;47:488-498 pubmed publisher
    ..IL-3 further induced degranulation of eosinophils on aggregated IgG via increased production and activation of both CD32 (low affinity IgG receptor) and αMß2 integrin...
  67. Kalantari Dehaghi M, Anhalt G, Camilleri M, Chernyavsky A, Chun S, Felgner P, et al. Pemphigus vulgaris autoantibody profiling by proteomic technique. PLoS ONE. 2013;8:e57587 pubmed publisher
    ..exceeded that of control by 10 and more times were the molecules encoded by the CD33, GP1BA, CHRND, SLC36A4, CD1B, CD32, CDH8, CDH9, PMP22 and HLA-E genes as well as mitochondrial proteins encoded by the NDUFS1, CYB5B, SOD2, PDHA1 and ..
  68. Hirako I, Gallego Marin C, Ataide M, Andrade W, Gravina H, Rocha B, et al. DNA-Containing Immunocomplexes Promote Inflammasome Assembly and Release of Pyrogenic Cytokines by CD14+ CD16+ CD64high CD32low Inflammatory Monocytes from Malaria Patients. MBio. 2015;6:e01605-15 pubmed publisher
    ..mononuclear cells from acute malaria patients was found to be a CD14(+) CD16 (FcγRIIIA)(+) CD64 (FcγRI)(high) CD32 (FcγRIIB)(low) monocyte subset...
  69. Erbe A, Wang W, Gallenberger M, Hank J, Sondel P. Genotyping Single Nucleotide Polymorphisms and Copy Number Variability of the FCGRs Expressed on NK Cells. Methods Mol Biol. 2016;1441:43-56 pubmed publisher
    ..The FCGRs, FCGR3A and FCGR2C, expressed on the surface of NK cells have single nucleotide polymorphisms (SNPs) that result in differential ..
  70. Yang Z, Xu J, Zhu R, Liu L. Down-Regulation of miRNA-128 Contributes to Neuropathic Pain Following Spinal Cord Injury via Activation of P38. Med Sci Monit. 2017;23:405-411 pubmed
    ..miR-128 overexpression significantly decreased the expression levels of microglial M1 phenotypic markers CD86 and CD32, and increased the expression levels of M2 phenotypic markers Arg1 and CD206...
  71. Zhang Y, Clark L, Sheng X, Zhou C. Successful en bloc venous resection with reconstruction and subsequent radiotherapy for 2 consecutive recurrences of intravenous leiomyoma--a case report. BMC Cancer. 2016;16:6 pubmed publisher
    ..On Immunohistochemical staining, the tumor cells were positive for CD32, CD34, Vimentin and smooth muscle actin...
  72. Trivedi S, Srivastava R, Concha Benavente F, Ferrone S, Garcia Bates T, Li J, et al. Anti-EGFR Targeted Monoclonal Antibody Isotype Influences Antitumor Cellular Immunity in Head and Neck Cancer Patients. Clin Cancer Res. 2016;22:5229-5237 pubmed
    ..Panitumumab may activate monocytes through CD32 (FcγRIIa); however, monocytes activated by either mAb are not able to mediate ADCC...
  73. Choi B, Suh C, Kim H, Sayeed H, Sohn S. The Correlation of CD206, CD209, and Disease Severity in Behçet's Disease with Arthritis. Mediators Inflamm. 2017;2017:7539529 pubmed publisher
    ..The frequencies of several pattern recognition receptors (CD11b, CD11c, CD32, CD206, CD209, and dectin-1) were analyzed in patients with BD by flow cytometry, and cytokine levels, interleukin- ..
  74. Font Haro A, Janovec V, Hofman T, Machala L, Jilich D, Melkova Z, et al. Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART. Viruses. 2018;10: pubmed publisher
    ..higher pDC-surface expression of the HIV-1 receptor CD4, regulatory receptor BDCA-2, Fcγ receptor CD32, pDC dysfunction marker TIM-3, and the marker of killer pDC, TRAIL, in treatment-naïve HIV-1-infected ..
  75. Tsang A Sjoe M, Nagelkerke S, Bultink I, Geissler J, Tanck M, Tacke C, et al. Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis. Rheumatology (Oxford). 2016;55:939-48 pubmed publisher
    ..00; 95% CI: 1.33, 2.99), and the 2B.4 haplotype of FCGR2B (OR 1.59; 95% CI: 1.13, 2.24), but not FCGR2C open reading frame, were significantly (all P < 0.01) and independently associated with susceptibility to SLE...
  76. Clark R, Pellom S, Booker B, Ramesh A, Zhang T, Shanker A, et al. Validation of research trajectory 1 of an Exposome framework: Exposure to benzo(a)pyrene confers enhanced susceptibility to bacterial infection. Environ Res. 2016;146:173-84 pubmed publisher
    ..induced suppression of macrophage function by examining the resultant effects of exposure-induced insult on CD32-lipid raft interactions in the regulation of IgG binding to CD32...
  77. Moretti R, Leger P, Besson V, Csaba Z, Pansiot J, Di Criscio L, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016;13:95 pubmed publisher
    ..Gene expression profiles indicated that sildenafil treatment also modulates M1- (ptgs2, CD32 and CD86) and M2-like (CD206, Arg-1 and Lgals3) microglia/macrophages in the late phase after pMCAo...
  78. Sergijenko A, Roelofs A, Riemen A, De Bari C. Bone marrow contribution to synovial hyperplasia following joint surface injury. Arthritis Res Ther. 2016;18:166 pubmed publisher
    ..The phenotype of GFP-labelled cells was determined by co-staining for the haematopoietic marker CD16/CD32 and the MSC/fibroblast marker platelet-derived growth factor receptor ? (Pdgfr?)...
  79. Vollack N, Friese J, Bergmann S, Tiede A, Werwitzke S. CD32 inhibition and high dose of rhFVIII suppress murine FVIII-specific recall response by distinct mechanisms in vitro. Thromb Haemost. 2017;117:1679-1687 pubmed publisher
    ..Previous data from haemophilia A mouse model demonstrates that both CD32 inhibition and high doses of rhFVIII prevent the differentiation of FVIII-specific memory B cells (MBCs) into ..
  80. Marchi L, Paoliello Paschoalato A, Oliveira R, Azzolini A, Kabeya L, Donadi E, et al. Activation status of peripheral blood neutrophils and the complement system in adult rheumatoid arthritis patients undergoing combined therapy with infliximab and methotrexate. Rheumatol Int. 2018;38:1043-1052 pubmed publisher
    ..levels of reactive oxygen species (ROS) generation (chemiluminescence assay) and membrane expression of FcγRIIa/CD32, FcγRIIIb/CD16, CR1/CD35, and CR3/CD11b receptors (ELISA assay) in neutrophils...
  81. Kam T, Park H, Gwon Y, Song S, Kim S, Moon S, et al. Fc?RIIb-SHIP2 axis links A? to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model. elife. 2016;5: pubmed publisher
    ..Thus, we concluded that the Fc?RIIb-SHIP2 axis links A? neurotoxicity to tau pathology by dysregulating PtdIns(3,4)P2 metabolism, providing insight into therapeutic potential against AD. ..
  82. Su J, Zhou H, Liu X, Nilsson J, Fredrikson G, Zhao M. oxLDL antibody inhibits MCP-1 release in monocytes/macrophages by regulating Ca2+ /K+ channel flow. J Cell Mol Med. 2017;21:929-940 pubmed publisher
    ..The interfering of oxLDL-induced MCP-1 release by its monoclonal antibody is through its Fc?RIIB (CD32)...
  83. Cheng W, Ren X, Zhang C, Cai J, Liu Y, Han S, et al. Bioinformatic profiling identifies an immune-related risk signature for glioblastoma. Neurology. 2016;86:2226-34 pubmed publisher
  84. Wines B, Vanderven H, Esparon S, Kristensen A, Kent S, Hogarth P. Dimeric Fc?R Ectodomains as Probes of the Fc Receptor Function of Anti-Influenza Virus IgG. J Immunol. 2016;197:1507-16 pubmed publisher
    ..Cells expressing the low-affinity Fc?Rs (Fc?RII or CD32 and Fc?RIII or CD16) are activated for these functions when receptors are aggregated following the binding of IgG-..
  85. Li W, Yang H, Dimitrov D. Identification of high-affinity anti-CD16A allotype-independent human antibody domains. Exp Mol Pathol. 2016;101:281-289 pubmed publisher
    ..with EC50 of 4nM and 8nM, respectively, but not other Fc gamma receptors (Fc?Rs) such as CD64 (Fc?RI), CD32 (Fc?RII) and CD16B (Fc?RIIIB)...
  86. Rahbari R, Zuccherato L, Tischler G, Chihota B, Oztürk H, Saleem S, et al. Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fc? Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis. Hum Mutat. 2017;38:390-399 pubmed publisher
    ..In humans, five low-affinity receptors are encoded by the genes FCGR2A, FCGR2B, FCGR2C, FCGR3A, and FCGR3B, which are located in an 82.5-kb segmental tandem duplication on chromosome 1q23...
  87. Borriello F, Iannone R, Di Somma S, Vastolo V, Petrosino G, Visconte F, et al. Lipopolysaccharide-Elicited TSLPR Expression Enriches a Functionally Discrete Subset of Human CD14+ CD1c+ Monocytes. J Immunol. 2017;198:3426-3435 pubmed publisher
  88. Werwitzke S, Vollack N, von Hornung M, Kalippke K, Kutzschbach J, Trummer A, et al. Deletion or inhibition of Fc gamma receptor 2B (CD32) prevents FVIII-specific activation of memory B cells in vitro. Thromb Haemost. 2015;114:1127-35 pubmed publisher
    ..Fc gamma receptor 2B (CD32) is an important regulator of B cell function, mediating inhibitory signals after cross-linking with the B cell ..
  89. Lombardi R, Chen S, Ruggiero A, Gurha P, Czernuszewicz G, Willerson J, et al. Cardiac Fibro-Adipocyte Progenitors Express Desmosome Proteins and Preferentially Differentiate to Adipocytes Upon Deletion of the Desmoplakin Gene. Circ Res. 2016;119:41-54 pubmed publisher
    ..platelet-derived growth factor receptor-? and exclude those expressing other lineage and fibroblast markers (CD32, CD11B, CD45, Lys76, Ly(-6c) and Ly(6c), thymocyte differentiation antigen 1, and discoidin domain receptor 2)...
  90. Meng H, Li X, Chen Y, Yu L, Zhang H, Lao J, et al. Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia. CNS Neurosci Ther. 2016;22:771-81 pubmed publisher
    ..In vivo, compared with wild-type mice, M1 markers (CD16, CD32 and iNOS) were attenuated in gld mice after MCAO. In vitro, post-OGD neuron released more sFasL...
  91. Kim H, Choi B, Suh C, Han M, Jung J, Sayeed H, et al. Highly Expression of CD11b and CD32 on Peripheral Blood Mononuclear Cells from Patients with Adult-Onset Still's Disease. Int J Mol Sci. 2017;18: pubmed publisher
    We investigated the potential role of several pattern-recognition receptors (PRRs; CD11b, CD11c, CD32, CD206, CD209, and dectin-1) in adult-onset Still's disease (AOSD)...
  92. Nakai K, Tanaka H, Yamanaka K, Takahashi Y, Murakami F, Matsuike R, et al. Effects of C-reactive protein on the expression of matrix metalloproteinases and their inhibitors via Fcγ receptors on 3T3-L1 adipocytes. Int J Med Sci. 2017;14:484-493 pubmed publisher
    ..Fcγ receptor (FcγR) IIb and FcγRIII, which are candidates for CRP receptors, and the effects of anti-CD16/CD32 antibodies, which can act as FcγRII and FcγRIII blockers on CRP-induced alteration of MMP and TIMP expression...